CN103340940A - Tibetan medicament for treating constipation and preparation method thereof - Google Patents
Tibetan medicament for treating constipation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a tibetan medicament for treating constipation and a preparation method thereof. The tibetan medicament consists of active components or active components and pharmaceutically acceptable auxiliaries, wherein the active components are prepared from whim, purpurea halitium, cassiae fructus, tronae and rheum officinale in a certain weight ratio. The tibetan medicament can be produced into an arbitrary common internal preparation, has the functions of clearing heat accumulation, and breaking stasis and eliminating mass, and can be used for treating gastrointestinal accumulated masses, constipation, belch and abdominal pain, gastrointestinal function degradation and other symptoms. The tibetan medicament can be used in constipation with remarkably reduced defection times caused by internal heat and qi depression (every 2-3 days or even longer period per time), irregular constipation, hard excrement and the like.
Description
Technical field
The present invention relates to a kind of Tibetan medicine for the treatment of constipation and preparation method thereof, belong to the Tibetan medicine field.
Background technology
Constipation is one group of different substantiality disease, mainly show as drain knot just, defecation effort and defecation frequency reduce.Constipation is the common disease that is caused by Different types of etiopathogenises, also can cause constipation as gastroenteropathy, the gastral systemic disease of accumulative total, many medicines.
Habitual constipation refers to long-term, chronic functional constipation is mainly in the old people.Be clinical common chronic digestible road symptom, it is really up to the mark mainly to show as defecation frequency minimizing, difficult defecation or feces.Be common in constitutional enterokinesia dysfunction, stool wriggling is carried and is delayed or megacolon etc.Result from that anxiety, pressure are big, the enterogastric peristalsis imbalance more, perhaps having just meaning bear just, form vicious cycle, cause habitual constipation.
Though itself be not a kind of disease, but be found in the multiple disease, change along with dietary structure, spirit psychology and society factors, the sickness rate of constipation rises gradually, have a strong impact on people's quality of life, and play an important role in the generation of diseases such as colon cancer, hepatic encephalopathy, mastopathy, presenile dementia, constipation can cause the life accident when diseases such as acute myocardial infarction, cerebrovascular accident.Therefore early prevention and rational therapy constipation, the serious consequence and the burden on society that bring of alleviate constipation greatly.
Evil greatly although this is critically ill, but better solution is not arranged at present as yet, and the medicine of Western medicine, Chinese medicine, collaborative treatment of Chinese and western medicines constipation is also a lot, and has obtained certain curative effect, but still have some patients to emplastic unsatisfactory curative effect commonly used, or can not use because of its side effect; And Tibetan medicine treatment constipation then has advantages such as effect is obvious, side effect is little.
Therefore, there is tight demand in people's Tibetan medicinal preparation that curative effect is better treated constipation.Up to now, also do not find the report of any relevant Tibetan medicine compositions of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has found Tibetan medicine oral drugs that the treatment of better curative effect constipation is arranged and preparation method thereof finally, thereby has finished the present invention.
Summary of the invention
The object of the invention just provides a kind of Tibetan medicine of more effectively treating constipation.
Another object of the present invention has provided the preparation method of this Tibetan medicine.
The present invention is a kind of Tibetan medicine, is formed or is made up of active component and acceptable accessories by active component, and wherein said active component is made up of following bulk drugs: Herba Oxytropis Kansuensis, Sal Ammoniacus, sausage fruit, Tronae, Radix Et Rhizoma Rhei.
It has selected Herba Oxytropis Kansuensis, Sal Ammoniacus, sausage fruit, Tronae, Radix Et Rhizoma Rhei to make up as crude drug, and wherein (1) Herba Oxytropis Kansuensis is the dry herb of leguminous plant Herba Oxytropis falcatae Oxytropis falcata Bunge and Herba Oxytropis chiliophyllae O.chiliophylla Royle.Has heat-clearing and toxic substances removing, the granulation promoting skin ulcer that heals, the effect of hesitant pulse hemostasis, relieving constipation; Be used for the treatment of epidemic disease, toxonosis, grasserie, constipation, anthrax.(2) Sal Ammoniacus is halogenide class halite family halite, main sodium chloride-containing (NaCl).Has the stomach warming relieving constipation, the effect of relieving distension; The complication that is used for " Baconic " and " dragon ", abdominal distention borborygmus, constipation, choke,hiccup and regurgitation.(3) sausage really is the dry mature fruit of leguminous plant Cassia fistula L. Cassia fistula L..Has removing heat from the liver, detoxifcation, detumescence, the effect of capturing; Be used for hepatitis, liver poisoning, constipation, limb edema.(4) Tronae is Sulfates nahcolite scale family mineral trona, the main sodium carbonate (Na that contains
2CO
3).Have removing toxic substances and promoting pus discharge, eliminate indigestion and phlegm, the effect of anthelmintic relieving constipation; Be used for Baconic's flatulence, dyspepsia, skin infection, parasitosis, toxic hepatitis, it is unfavorable to defecate.(5) Radix Et Rhizoma Rhei is the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim. Ex Balf. or Rheum officinale Rheum officinale Baill..Have that purging heat to relax the bowels, removing toxicity for eliminating carbuncles, clots absorbing stimulate the menstrual flow, the effect of removing damp-heat, cooling blood for hemostasis; Be used for that the gastrointestinal excess-heat is stagnant, constipation, abdominal part distension, pain with tenderness, even the cold accumulation and constipation of hyperpyrexia, unconsciousness and delirium or spleen YANG deficiency, pathopyretic ulcer, sudden and violent acute conjunctivitis pain, aphtha of the mouth and tongue, gingivitis, menstruation apolipsis, postpartum stagnation, lump in the abdomen and the traumatic injury of stagnation of blood stasis, swelling and pain due to blood stasis, the jaundice of stagnation of damp-heat, dysuria, constipation with dry stool, pyretic stranguria, stranguria caused by urinary stone, also can be used for injury of blood collaterals by heat haematemesis, epistaxis, have blood in stool, metrorrhagia, red and white leukorrhea be inferior.
These crude drug are used in combination make each crude drug effect produce synergism, thereby can effectively treat constipation.
The consumption of Tibetan medicine component of the present invention is also groped to sum up to draw through the inventor in a large number, and each crude drug consumption is: Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g.
The preparation of Tibetan medicine active component of the present invention can be the crude drug convection drying of above-mentioned consumption to be pulverized make; Also the crude drug of above-mentioned consumption can be adopted the conventional method of Chinese medicine preparation such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation (referring to Cao Chunlin chief editor's " pharmaceutics of Chinese drugs " the 73rd～74 page, Science and Technology of Shanghai publishing house publishes in November, 1986) to make.
The active component of Tibetan medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine (referring to Cao Chunlin chief editor's " pharmaceutics of Chinese drugs ", Science and Technology of Shanghai publishing house publishes in November, 1986) be prepared into any peroral dosage form commonly used, as powder, pill, capsule, granule, tablet etc.
Tibetan medicine of the present invention has the effect of the knot that purges heat clearly, the broken stagnant painful abdominal mass that disappears.Be used for the long-pending knot of gastrointestinal mass in the abdomen, constipation, belch stomachache, gastrointestinal function that wooden brucellosis causes and disease such as weaken; Be used for constipation and mostly be defecation frequency due to the interior-heat stagnation of QI and obviously reduce (per 2～3 days or longer time/time), irregular, feces is really up to the mark etc.
[specific embodiment]
Come further to set forth the preparation method of Tibetan medicine of the present invention by the following examples.
The preparation of [embodiment 1] Tibetan medicine powder of the present invention:
Take by weighing Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g, be ground into fine powder after the mixing jointly, mixing, packing namely gets powder.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The preparation of [embodiment 2] Tibetan medicine pill of the present invention:
Take by weighing Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g, be ground into fine powder after the mixing jointly, mixing is used water pill, dry below 60 ℃, and polishing, packing namely gets pill.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The preparation of [embodiment 3] Tibetan medicine granule of the present invention:
Take by weighing Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g, be ground into fine powder after the mixing jointly, mixing adds adjuvant and makes granule, dry below 60 ℃, and granulate, packing namely gets granule.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The preparation of [embodiment 4] Tibetan medicine capsule of the present invention:
Take by weighing Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g, be ground into fine powder after the mixing jointly, mixing, the gelatine capsule of packing into namely gets capsule.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The preparation of [embodiment 5] Tibetan medicine tablet of the present invention:
Take by weighing Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g, be ground into fine powder after the mixing jointly, mixing adds adjuvant and makes granule, dry below 60 ℃, and granulate, tabletting namely gets tablet.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
Below further sets forth the beneficial effect of Tibetan medicine of the present invention by testing example, these are tested the routine pharmacodynamics test of Tibetan medicine embodiment 1 powder of the present invention and the clinical observation on the therapeutic effect of having comprised and test.
Tests such as the defecation of [test example 1] Tibetan medicine embodiment 1 powder of the present invention, intestinal propulsion motion, large intestine ahead running, the influence of intestinal volume, functions of loosening bowel relieving constipation:
Test material: anthology invention Tibetan medicine embodiment 1 powder is trial drug; DAHUANG TONGBIAN JIAONANG is produced by Jianjiang Pharmaceutical Factory, batch number 20100506; India ink is produced by chemical plant in the west, Beijing, batch number 20100308; Compound diphenoxylate is produced by Jiaozuo City Kang Li Pharmaceutical limited company, batch number 20100712; Pentobarbital sodium, SERVA import packing, the chemical plant product is known in last sea-run, batch number 20100604; Kunming mouse, Wistar rat are provided by the Lanzhou Experimental Animal Center.
Experimental technique: 1, Tibetan medicine embodiment 1 powder of the present invention is tested the defecation of dryness accumulated in the stomach and intestine dehydration constipation model mice: get body weight 24～26g healthy mice, male and female half and half, be divided into 6 groups at random by body weight, if blank group, model control group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and Tibetan medicine embodiment of the present invention 1 powder (2g/kg, 4g/kg, 8g/kg) basic, normal, high dosage group.Except the blank group, other are respectively organized mice and prohibit water non-fasting 72h, cause dryness accumulated in the stomach and intestine dehydration constipation model.The blank group is irritated stomach and is given the 2% india ink suspension that is configured to distilled water, the administration group is then irritated the 2% india ink suspension that stomach gives to replace with medicinal liquid distilled water, administration volume 1mL/20g body weight, after the administration mice put into the mice box, 1 in every box, the clean filter paper of underlay white, every mice of observed and recorded are discharged the time (min) of melena and the melena sum that the interior mice of 4h is discharged first.T checks the significance of each group difference, the results are shown in Table 1.
Table 1 Tibetan medicine embodiment 1 powder of the present invention to the influence of dryness accumulated in the stomach and intestine dehydration constipation model mice defecation (x ± s, n=10)
Group number of animals dosage (g/kg) is arranged the interior row of melena time (min) 4h melena first and is counted
Blank group 10 194.8 ± 67.8
2.5 ± 1.7
Model control group 10 358.3 ± 16.4
#0.3 ± 1.7
#
Positive controls 10 0.5 325.8 ± 63.4 0.8 ± 1.7
Low dose group 10 2 337.2 ± 68.8 0.5 ± 1.6
Middle dosage group 10 4 269.7 ± 79.8
*1.8 ± 2.4
*
High dose group 10 8
231.4 ± 68.6
*2.9 ± 2.8
*
Illustrate: with the blank group relatively:
#P＜0.01; With the model matched group relatively:
*P＜0.05;
*P＜O.0l.
2, Tibetan medicine embodiment 1 powder of the present invention is tested the defecation of compound diphenoxylate (DC) model mice: animal and grouping are with 1, each is organized mice and prohibits water non-fasting 12h, except the blank group was given the equivalent distilled water, all the other each groups were irritated stomach and are given compound diphenoxylate (DC) suspension 50mg/kg.Behind the 30min, each treated animal is irritated stomach and is subjected to the reagent thing, administration volume 1mL/20g body weight, and blank group and model control group are given the equivalent distilled water.The argol that every group of mice of observed and recorded discharged is counted, loose stool is counted and the number of animals of defecation not, observes 12h continuously, respectively organizes index, and t checks the significance of each group difference, the results are shown in Table 2.
Table 2 Tibetan medicine embodiment 1 powder of the present invention to the influence of DC constipation model mice defecation (x ± s, n=10)
Group number of animals dosage (g/kg) the argol loose stool not defecation number of animals of counting of counting
Blank group 10 8.3 ± 4.18 00
Model control group 10 2.4 ± 2.57
#00
Positive controls 10 0.5 3.8 ± 1.24 00
Low dose group 10 2 4.0 ± 3.43 0.3 ± 0.47 0
Middle dosage group 10 4 4.9 ± 2.68
*0.5 ± 0.27 0
High dose group 10 8 9.6 ± 3.14
*1.9 ± 1.15
*0
Illustrate: with the blank group relatively:
#P＜0.01; With the model matched group relatively:
*P＜0.05;
*P＜O.0l.
3, Tibetan medicine embodiment 1 powder of the present invention is tested the defecation of normal mouse: get body weight 24～26g healthy mice, male and female half and half, be divided into 5 groups at random by body weight, if blank group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and Tibetan medicine embodiment of the present invention 1 powder (2g/kg, 4g/kg, 8g/kg) basic, normal, high dosage group.The blank group is irritated stomach and is given the 2% india ink suspension that is configured to distilled water, and the administration group is then irritated stomach and given the 2% india ink suspension that replaces distilled water to be configured to medicinal liquid, and the administration volume is the 1mL/20g body weight.After the administration mice is put into the mice box, 1 in every box, the clean filter paper of underlay white, every mice of observed and recorded is discharged the time (min) of melena and the sum that the interior mice of 4h is discharged melena first.T checks the significance of each group difference, the results are shown in Table 3.
Table 3 Tibetan medicine embodiment 1 powder of the present invention to the influence of normal mouse defecation (x ± s, n=10)
Group number of animals dosage (g/kg) is arranged the interior row of melena time (min) 4h melena first and is counted
Blank group 10 151.7 ± 74.4 2.6 ± 2.66
Positive controls 10 0.5 118.2 ± 43.2 7.1 ± 2.46
*
Low dose group 10 2 141.6 ± 54.3 4.3 ± 1.48
Middle dosage group 10 4 114.4 ± 51.5
5.8 ± 2.68
*
High dose group 10 8 96.6 ± 42.8
*8.6 ± 2.47
*
Illustrate: with the model matched group relatively:
*P＜0.05;
*P＜O.0l.
4, Tibetan medicine embodiment 1 powder of the present invention is tested the mouse small intestine ahead running: animal and grouping are with 3, be mark with the carbon ink, the blank group is irritated stomach and is given the 7% carbon ink suspension that is configured to normal saline, the administration group is then irritated stomach and is given the 7% carbon ink suspension that replaces distilled water to be configured to medicinal liquid, the administration volume is the 0.4mL/20g body weight, 30min behind the filling stomach, mice is put to death in the cervical vertebra dislocation, the taking-up gastrointestinal of cutting open the belly immediately, be tiled on the glass plate, measure displacement and the small intestinal total length (from pylorus to ileum) of carbon ink head end in intestinal tube, calculate and advance percentage rate, the distance of carbon ink propelling rate=carbon ink front end and pylorus/small intestinal total length * 100%.T checks the significance of each group difference, the results are shown in Table 4.
The influence that table 4 Tibetan medicine embodiment 1 powder of the present invention advances small intestine movement of mice (x ± s, n=10)
Group number of animals dosage (g/kg) small intestinal length (cm) carbon ink advance distance (cm) advances percentage rate (%)
Blank group 10 53.2 ± 2.14 41.5 ± 3.39 77.17 ± 6.15
Positive controls 10 0.5 49.4 ± 4.13 44.3 ± 6.27 91.36 ± 12.18
*
Low dose group 10 2 48.7 ± 5.77 37.4 ± 6.17 79.36 ± 9.14
Middle dosage group 10 4 49.8 ± 3.65 43.7 ± 6.58 88.67 ± 9.13
*
High dose group 10 8 49.3 ± 4.26 46.9 ± 5.18
*96.15 ± 6.12
*
Illustrate: with the model matched group relatively:
*P＜0.05;
*P＜O.0l.
5, Tibetan medicine embodiment 1 powder of the present invention is tested rat large intestine ahead running: get body weight 250～350g healthy adult rat, all male, be divided into 5 groups at random by body weight, if blank group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and Tibetan medicine embodiment of the present invention 1 powder (2g/kg, 4g/kg, 8g/kg) basic, normal, high dosage group.Anesthetized rat during experiment, abdominal part cropping then along the median line otch, is opened the abdominal cavity and is found caecum and colon junction.Blank group rat is injected the normal saline that contains 10% india ink in this one in colonic lumen, the administration group is then injected the medicinal liquid that contains 10% india ink, administration volume 2.5mL/kg body weight.5min after the administration opens the abdominal cavity immediately, separates and cuts large intestine, takes out, and pendulum is straight naturally, measures the distance that large intestine length and prepared Chinese ink advance with meter ruler, calculates the propelling percentage rate, carbon ink propelling rate=carbon ink advance distance/large intestine total length * 100%.T checks the significance of each group difference, the results are shown in Table 5.
The influence that table 5 Tibetan medicine embodiment 1 powder of the present invention advances the normal rat large intestine (x ± s, n=10)
Group number of animals dosage (g/kg) large intestine length (cm) carbon ink advance distance (cm) advances percentage rate (%)
Blank group 10 16.1 ± 1.8 6.1 ± 2.4 38.2 ± 15.8
Positive controls 10 0.5 15.3 ± 0.8 8.2 ± 3.5 54.2 ± 27.6
*
Low dose group 10 2 16.7 ± 1.6 9.7 ± 4.1
*59.8 ± 21.7
*
Middle dosage group 10 4 16.2 ± 0.7 10.1 ± 3.2
*63.4 ± 21.8
*
High dose group 10 8 15.8 ± 1.8 11.8 ± 2.1
*72.8 ± 21.3
*
Illustrate: with the model matched group relatively:
*P＜0.05;
*P＜O.0l.
6, Tibetan medicine embodiment 1 powder of the present invention influences test to mice intestinal volume: animal and grouping are with 3, and after water 12h was can't help in fasting, each organized gastric infusion according to dosage, and the blank group is given equivalent distilled water, administration volume 1mL/20g body weight.Behind the administration 2.5h the disconnected cervical vertebra of animal is put to death, cut off the abdominal cavity, expose intestinal tube, in pylorus lower end and ileocecus ligation, the place cuts intestinal tube from pylorus, carefully cuts mesentery with little shears downwards along intestinal tube, cut off intestinal tube at ileocecus, accurate weighing intestinal tube weight on electronic balance.T checks the significance of each group difference, the results are shown in Table 6.
Table 6 Tibetan medicine embodiment 1 powder of the present invention to the influence of mice intestinal volume (x ± s, n=10)
Group number of animals dosage (g/kg) intestinal tube weight (g)
Blank group 10 1.28 ± 0.24
Positive controls 10 0.5 1.53 ± 0.47
Low dose group 10 2 1.49 ± 0.12
Middle dosage group 10 4 1.43 ± 0.17
*
High dose group 10 8 1.58 ± 0.43
*
Illustrate: with the model matched group relatively:
*P＜0.05.
7, Tibetan medicine embodiment 1 powder of the present invention is tested the mice functions of loosening bowel relieving constipation: animal and grouping are with 3, and each organizes gastric infusion according to dosage, and the blank group is given equivalent distilled water, administration volume 1mL/20g body weight.After the administration mice is put into the mice box, 1 in every box, the clean filter paper of underlay white time and the character of soft stool, loose stool, loose stool occurs the 1st time in the record 4h, represents purging and intestine lubricating action with soft stool, represents defecating feces excretion with loose stool, represents discharge function with loose stool.Soft stool refers to that excrement is shaped, but softly expands that to contain moisture more, and loose stool slightly is shaped or is shapeless, scattered paste shape, loose stool scattered paste shape or water liquid.T checks the significance of each group difference, the results are shown in Table 7.
Table 7 Tibetan medicine embodiment 1 powder of the present invention to the influence of mice loosening bowel to relieve constipation (x ± s, n=10)
Group number of animals dosage (g/kg) soft stool time (min) loose stool time (min) loose stool time (min)
Blank group 10 134.4 ± 10.8 242.0 242.0
Positive controls 10 0.5 53.4 ± 61.7 186.3 ± 91.4 242.0
Low dose group 10 2 52.6 ± 78.2 183.2 ± 94.2 242.0
Middle dosage group 10 4 36.7 ± 24.3
*127.4 ± 91.7
*203.8 ± 68.4
High dose group 10 8 27.8 ± 29.7
*121.1 ± 91.4
*171.6 ± 89.3
Illustrate: with the model matched group relatively:
*P＜0.05;
*P＜O.0l.
The result shows: the time that the middle and high dosage of Tibetan medicine embodiment 1 powder of the present invention can make dryness accumulated in the stomach and intestine dehydration constipation model mice discharge melena first shortens, the total argol of discharge melena color dot is counted and is increased in the mice 4h, the number of animals of defecation does not reduce, high dose can make the argol of discharging in the DC constipation model mice 12h count to increase, loose stool is counted and is increased, and the number of animals of defecation does not reduce; Compare with model control group, its difference all has statistical significance.The middle dosage of Tibetan medicine embodiment 1 powder of the present invention can make the interior melena color dot sum of discharging of normal mouse 4h increase, the time that high dose can make normal mouse discharge melena first shortens, discharging melena color dot sum in the mice 4h increases, compare with the blank group, its difference also has statistical significance, points out 1 pair of dryness accumulated in the stomach and intestine dehydration of Tibetan medicine embodiment of the present invention constipation model mice, DC constipation model mouse and normal mouse all to have and promotes the discharge function that animal drains more significantly.The middle and high dosage of Tibetan medicine embodiment 1 powder of the present invention can promote mouse small intestine prepared Chinese ink advance distance; The basic, normal, high dosage of Tibetan medicine embodiment 1 powder of the present invention can promote rat large intestine prepared Chinese ink advance distance, compare with the blank group, its difference all has statistical significance, point out Tibetan medicine embodiment 1 powder of the present invention that the ahead running that promotes intact animal's small intestinal, large intestine is arranged, strengthen the function of enterokinesia.The middle and high dosage of Tibetan medicine embodiment 1 powder of the present invention can obviously increase the mouse small intestine moisture, mice intestinal tube weight is increased, it is big that the intestinal volume becomes, making mice soft stool, loose stool time occur obviously shortens, compare with the blank group, its difference all has statistical significance, point out Tibetan medicine embodiment 1 powder of the present invention to have more significantly to reduce intestinal to moisture absorption, make the softening functions of loosening bowel relieving constipation of stool.Above result shows that Tibetan medicine embodiment 1 powder of the present invention has stronger promotion animal defecation, increases enterokinesia and functions of loosening bowel relieving constipation, therefore, clinically constipation is had certain value.
The clinical observation on the therapeutic effect of [test example 2] 1, Tibetan medicine embodiment 1 powder of the present invention treatment constipation:
Physical data: constipation patient is totally 120 examples, is divided into two groups at random by digital method, and 60 examples are organized in treatment, male 37 examples, women 23 examples, 52.5 years old mean age; Matched group 60 examples, male 36 examples, women 24 examples, 53 years old mean age.The age of two groups of cases, sex and physical data difference not statistically significant.
Diagnostic criteria: according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", defecation time prolongs, and two days with the last time, the feces dry, hard; Weight person's difficulty in defecation, dry as chestnut can accompany few abdominal distention anxious, and is refreshing tired weak, and the stomach poor appetite such as moves back at disease.
Exclusion standard: get rid of the intestinal organic disease.
Therapeutic Method: treatment group: adopt Tibetan medicine embodiment 1 powder of the present invention, oral; A 4g, 3 times on the one.Matched group: DAHUANG TONGBIAN JIAONANG, 0.9g/ time, 1 day 1 time, the preceding warm water delivery service of sleeping evening.Two groups is 1 course for the treatment of to treat 15 days all, finishes the statistics therapeutic outcome 1 course for the treatment of.
Clinical efficacy evaluation criteria: according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", cure: just matter was changeed profit with interior defecation 1 time in 2 days, and unobstructed during solution, short-term does not have recurrence; Take a turn for the better: just matter was changeed profit with interior defecation in 3 days, and it is smooth that defecation is owed; Do not heal: symptom does not have improvement.Healing adding improvement and adding up to total effective rate.
Clinical observation result sees Table 8.
Table 8 liang group curative effect comparison (example, %)
Group example number is cured the more total effective rate that takes a turn for the better not
Treatment organizes 60 42 16 2 96.67
*
Matched group 60 36 18 6 90.00
Annotate: compare with matched group
*P＜0.05.
Untoward reaction: have no adverse reaction in two groups of therapeutic processes; The check hepatic and renal function was all normal after finished two groups of courses for the treatment of.
Clinical observation result shows: Tibetan medicine embodiment 1 powder treatment constipation determined curative effect of the present invention, and be worth clinical expansion to use, have certain application prospect.
2, the clinical observation on the therapeutic effect of Tibetan medicine embodiment 1 powder treatment chronic constipation of the present invention:
Physical data: 60 routine patients all meet chronic constipation diagnostic criteria in the Rome II diagnostic criteria of constipation and the Chinese Medical Association's constipation diagnosis and treatment tentative standard.Male 23 examples wherein, women 37 examples, 38～71 years old age, average 50.5 years old, the course of disease 2.1～11 years, average course of disease 27.72 months.
Therapeutic Method: adopt Tibetan medicine embodiment 1 powder of the present invention, oral; A 4g, 3 times on the one.15 days was 1 course for the treatment of.
Clinical efficacy evaluation criteria: evaluate according to Ministry of Public Health Clinical Researches of New Drugs guideline.(1) produce effects: taking medicine reaches following index in back 3 days: 1. defecation frequency recovers normal; 2. the feces character transfers to normally; 3. defecation is unobstructed and do not have difficulty, does not have sense of discomfort during defecation.(2) effective: as to reach 1～2 person in listed 3 indexs in the produce effects.(3) invalid: after taking medicine 3 days, These parameters and the preceding all no significant differences for the treatment of.
Therapeutic outcome: this organizes 60 routine patients, after finishing the course for the treatment of, and produce effects 42 examples (70.00%); Effective 16 examples (26.67%); Invalid 2 examples (3.33%).Total effective rate 96.67%.Phone is paid a return visit still produce effects 37 examples (88.1%) of produce effects 42 examples after 60 days; Effective 12 examples (75.0%) still in effective 16 examples.Total effective rate 81.67% after namely 60 days.
Therapeutic outcome shows: Tibetan medicine embodiment 1 powder treatment constipation determined curative effect of the present invention is worth clinical expansion to use.
Claims (6)
1. Tibetan medicine for the treatment of constipation, it is characterized in that it is made up of active component or is made up of active component and acceptable accessories, wherein said active component is made up of the crude drug of following concrete weight: Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g.
2. Tibetan medicine according to claim 1, it is peroral dosage form.
3. Tibetan medicine according to claim 2, it is powder, pill, granule, capsule or tablet.
4. the preparation method of the described Tibetan medicine of claim 1, it comprises the following steps: to take by weighing the crude drug of following concrete weight: Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g; Mix, be ground into fine powder then jointly, mixing is made active component.
5. the preparation method of the described Tibetan medicine of claim 1, it comprises the following steps: to take by weighing the crude drug of following concrete weight: Herba Oxytropis Kansuensis 100g, Sal Ammoniacus 60g, sausage fruit 90g, Tronae 100g, Radix Et Rhizoma Rhei 150g; Mix, adopt decoction and alcohol sedimentation technique or ethanol extract from water precipitation to make active component.
6. according to claim 4 or 5 described preparation methoies, it also comprises the following steps: active component and acceptable accessories are made powder, pill, granule, capsule or tablet.
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| CN104257809A (en) * | 2014-10-23 | 2015-01-07 | 青海省通天河藏药制药有限责任公司 | Traditional Tibetan medicine for treating constipation |
| CN104257808A (en) * | 2014-10-23 | 2015-01-07 | 青海省通天河藏药制药有限责任公司 | Traditional Tibetan medicine for treating constipation |
| CN106387235A (en) * | 2016-11-24 | 2017-02-15 | 西宁志培知识产权咨询有限公司 | Method for preparing herbal tea with function of relieving intestinal dryness with constipation from food plants as components |
| CN115475198A (en) * | 2022-09-21 | 2022-12-16 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Traditional Chinese medicine composition for treating constipation and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257809A (en) * | 2014-10-23 | 2015-01-07 | 青海省通天河藏药制药有限责任公司 | Traditional Tibetan medicine for treating constipation |
| CN104257808A (en) * | 2014-10-23 | 2015-01-07 | 青海省通天河藏药制药有限责任公司 | Traditional Tibetan medicine for treating constipation |
| CN104257808B (en) * | 2014-10-23 | 2016-04-13 | 青海省通天河藏药制药有限责任公司 | A kind of Tibetan medicine for the treatment of constipation |
| CN104257809B (en) * | 2014-10-23 | 2016-05-04 | 青海省通天河藏药制药有限责任公司 | A kind of preparation method who treats constipation Tibetan medicine |
| CN106387235A (en) * | 2016-11-24 | 2017-02-15 | 西宁志培知识产权咨询有限公司 | Method for preparing herbal tea with function of relieving intestinal dryness with constipation from food plants as components |
| CN115475198A (en) * | 2022-09-21 | 2022-12-16 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Traditional Chinese medicine composition for treating constipation and preparation method thereof |
| CN115475198B (en) * | 2022-09-21 | 2023-08-11 | 解红霞 | Traditional Chinese medicine composition for treating constipation and preparation method thereof |
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Application publication date: 20131009 |