CN102716197A - Tibetan medicine for treating constipation and preparation method thereof - Google Patents
Tibetan medicine for treating constipation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Tibetan medicine for treating constipation. The Tibetan medicine consists of an active component or an active component and a pharmaceutically acceptable accessory, wherein the active component is prepared from fructus chebulae, tronae, rhubarb and chenopodium album according to a certain weight proportion. The Tibetan medicine can be prepared into any common dosage form for oral administration. The Tibetan medicine disclosed by the invention has the functions of clearing heat accumulation, breaking stagnation and dispersing mass, and is applied to the symptoms such as gastrointestinal mass and lump, constipation, belching and abdominal pain, gastrointestinal function weakening and the like caused by the wooden cloth sickness and applied to constipation with major symptoms that the defecation times are obviously reduced (every 2-3 days or longer), the defecation is irregular, the excrement is too hard and the like caused by internal heat and qi depression.
Description
Technical field
The present invention relates to a kind of Tibetan medicine of treating constipation and preparation method thereof, belong to the Tibetan medicine field.
Background technology
Constipation is one group of different substantiality disease, mainly show as drain knot just, defecation effort and defecation frequency reduce.Constipation is the common disease that is caused by Different types of etiopathogenises, also can cause constipation like gastroenteropathy, the gastral systemic disease of accumulative total, many medicines.
Habitual constipation is meant secular, chronic functional constipation is mainly in the old people.Be clinical common chronic digestible road symptom, it is really up to the mark mainly to show as defecation frequency minimizing, difficult defecation or feces.Be common in constitutional enterokinesia dysfunction, stool wriggling is carried and is delayed or megacolon etc.Result from that anxiety, pressure are big, the enterogastric peristalsis imbalance more, perhaps having just meaning bear just, form vicious cycle, cause habitual constipation.
Though itself be not a kind of disease; But be found in the multiple disease, along with the change of dietary structure, spiritual psychology and society factors; The sickness rate of constipation rises gradually; Have a strong impact on people's quality of life, and in the generation of diseases such as colon cancer, hepatic encephalopathy, mastopathy, presenile dementia, play an important role, constipation can cause life unexpected when diseases such as acute myocardial infarction, cerebrovascular accident.Therefore early prevention and rational therapy constipation, the serious consequence and the burden on society that bring of alleviate constipation greatly.
Evil greatly although this is critically ill; But better solution is not arranged at present as yet, and the medicine of Western medicine, Chinese medicine, collaborative treatment of Chinese and western medicines constipation is also a lot, and has obtained certain curative effect; But still have some patients to emplastic unsatisfactory curative effect commonly used, or can not use because of its side effect; And Tibetan medicine treatment constipation then has advantages such as effect is obvious, side effect is little.
Therefore, there is tight demand in people's Tibetan medicinal preparation that curative effect is better treated constipation.Up to now, also do not find the report of any relevant Tibetan medicine compositions of the present invention.The inventor is through research repeatedly, and the repeated validation through animal and clinical trial, found the Tibetan medicine oral drugs that the treatment of better curative effect constipation is arranged finally, thereby accomplished the present invention.
Summary of the invention
The object of the invention just provides a kind of Tibetan medicine of more effectively treating constipation.
Another object of the present invention has provided the method for preparing of this Tibetan medicine.
The present invention is a kind of Tibetan medicine, is formed or is made up of active component and acceptable accessories by active component, and wherein said active component is to be processed by following bulk drugs: Fructus Chebulae, JIANHUA, Radix Et Rhizoma Rhei, Herba chenopodii.
It has selected Fructus Chebulae, JIANHUA, Radix Et Rhizoma Rhei, Herba chenopodii to make up as raw material, and wherein (1) Fructus Chebulae is the dry mature fruit of Combretum Racemosum plant Fructus Chebulae Terminalia chebula Retz..Puckery, property is flat; Return lung, large intestine channel.Have nourishing and take care of health, rise stomach-fire, aid digestion, comfortable, the function that makes eye bright; Cure mainly the disease that " dragon ", " red crust ", " Baconic " bring out; Have pharmacological actions such as convergence, antidiarrheal, resisting pathogenic microbes, spasmolytic.(2) JIANHUA is a Sulfates nahcolite scale family mineral trona, main carbonated sodium (Na
2CO
3).Nature and flavor are sweet, salty, flat, little poison.Have removing toxic substances and promoting pus discharge, eliminate indigestion and phlegm, the function of anthelmintic relieving constipation; Be used for Baconic's flatulence, dyspepsia, skin infection, parasitosis, toxic hepatitis, it is unfavorable to defecate.(3) Radix Et Rhizoma Rhei is the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.Ex Balf. or Rheum officinale Rheum officinale Baill..Bitter in the mouth, cold in nature; Return stomach, spleen, large intestine, liver, pericardium channel.Have that purging heat to relax the bowels, removing toxicity for eliminating carbuncles, clots absorbing stimulate the menstrual flow, the effect of removing damp-heat, cooling blood for hemostasis.Be used for that the gastrointestinal excess-heat is stagnant, constipation, abdominal part distension, pain with tenderness; Even the cold accumulation and constipation of hyperpyrexia, unconsciousness and delirium or spleen YANG deficiency; Pathopyretic ulcer, sudden and violent acute conjunctivitis pain, aphtha of the mouth and tongue, gingivitis; Menstruation apolipsis, postpartum stagnation, lump in the abdomen and the traumatic injury of stagnation of blood stasis, swelling and pain due to blood stasis, the jaundice of stagnation of damp-heat, dysuria, constipation with dry stool, pyretic stranguria, stranguria caused by urinary stone, also can be used for injury of blood collaterals by heat haematemesis, epistaxis, have blood in stool, metrorrhagia, red and white leukorrhea be inferior; Modern clinical can be used for treating epidemic cerebrospinal meningitis, lobar pneumonia, acute biliary infection, acute parotitis, acute appendicitis, Fiedeler's disease type hepatitis, acute enteritis, bacillary dysentery, digestive tract hemorrhage, pharyngolaryngitis, gingival abscess, dermatitis, eczema, gonorrhea, herpes zoster etc.(4) Herba chenopodii is a Chenopodiaceae Chenopodium plant Herba chenopodii
Chenopodium albumL.,Edible or be used as medicine with herb.Property is put down, and is nontoxic, sweet in the mouth; Return spleen, stomach, intestinal warp.Effect with clearing away heat-fire, relieving constipation, detoxification and promoting urination, antipruritic rash; Cure mainly anemopyretic cold, dysentery, diarrhoea, eczema, prurigo, insect-bite.
The JIANHUA warming middle-JIAO for easing the stomach, QI and blood regulating, appetite-stimulating indigestion-relieving; Radix Et Rhizoma Rhei, Herba chenopodii play spleen invigorating, clear internal organs heat and rush down purgation imitates, and dyspepsia is got rid of, and can make distension, pain relief again; Again with king Fructus Chebulae's coordinating the actions of various ingredients in a prescription of many medicines of treating all diseases, play the knot that purges heat clearly, the broken merit of painful abdominal mass of disappearing that stagnates altogether.Make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat constipation.
The consumption of Tibetan medicine component of the present invention is also groped to sum up to draw through the inventor in a large number, and each crude drug consumption is for all to have better curative effect in the following weight parts scope: Fructus Chebulae 5～20g, JIANHUA 7～30g, Radix Et Rhizoma Rhei 15～60g, Herba chenopodii 15～60g.
Be preferably: Fructus Chebulae 10g, JIANHUA 15g, Radix Et Rhizoma Rhei 30g, Herba chenopodii 30g.
The preparation of Tibetan medicine active component of the present invention can be the crude drug convection drying of above-mentioned consumption to be pulverized process; Also can adopt conventional method such as the decoction and alcohol sedimentation technique of Chinese medicine preparation or ethanol extract from water precipitation (referring to Cao Chunlin chief editor's " pharmaceutics of Chinese drugs " the 73rd～74 page, Science and Technology of Shanghai publishing house publishes in November, 1986) to make the crude drug of above-mentioned consumption.
The active component of Tibetan medicine of the present invention can add various conventional adjuvant required when preparing different dosage form; Like disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine (referring to Cao Chunlin chief editor's " pharmaceutics of Chinese drugs "; Science and Technology of Shanghai publishing house publishes in November, 1986) be prepared into any peroral dosage form commonly used, like decoction pulvis, medicinal tea, powder, pill, capsule, granule, tablet etc.
Tibetan medicine of the present invention has the effect of the knot that purges heat clearly, the broken stagnant painful abdominal mass that disappears.Be used for the long-pending knot of gastrointestinal mass in the abdomen, constipation, belch stomachache, gastrointestinal function that wooden brucellosis causes and disease such as weaken; Be used for constipation and be mostly that defecation frequency due to the interior-heat stagnation of QI obviously reduces (per 2～3 days or longer time/inferior), irregular, feces is really up to the mark etc.
[specific embodiment]
Below come further to set forth Tibetan medicine of the present invention through embodiment method for preparing.
The decoction pulvis preparation of [embodiment 1] Tibetan medicine of the present invention:
Take by weighing Fructus Chebulae 10g, JIANHUA 15g, Radix Et Rhizoma Rhei 30g, Herba chenopodii 30g, be ground into coarse powder after the mixing jointly, mixing, packing promptly gets decoction pulvis.
Usage and dosage is: put in the 150ml water and decoct, during decocting to 1/3, taking liquid is drunk; A 5g, 2～4 times on the one.
The medicinal tea preparation of [embodiment 2] Tibetan medicine of the present invention:
Take by weighing Fructus Chebulae 15g, JIANHUA 10g, Radix Et Rhizoma Rhei 20g, Herba chenopodii 40g, be ground into coarse powder after the mixing jointly, mixing, packing promptly gets medicinal tea.
Usage and dosage is: boiled water brews to be drunk; A 5g, 2～4 times on the one.
The powder preparation of [embodiment 3] Tibetan medicine of the present invention:
Take by weighing Fructus Chebulae 20g, JIANHUA 25g, Radix Et Rhizoma Rhei 15g, Herba chenopodii 25g, be ground into fine powder after the mixing jointly, mixing, packing promptly gets powder.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The pill preparation of [embodiment 4] Tibetan medicine of the present invention:
Take by weighing Fructus Chebulae 20g, JIANHUA 20g, Radix Et Rhizoma Rhei 30g, Herba chenopodii 15g, be ground into fine powder after the mixing jointly, mixing is used water pill, dry below 60 ℃, and polishing, packing promptly gets pill.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The granule preparation of [embodiment 5] Tibetan medicine of the present invention:
Take by weighing Fructus Chebulae 15g, JIANHUA 10g, Radix Et Rhizoma Rhei 50g, Herba chenopodii 10g, be ground into fine powder after the mixing jointly, mixing adds adjuvant and processes granule, dry below 60 ℃, and granulate, packing promptly gets granule.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The capsule preparation of [embodiment 6] Tibetan medicine of the present invention:
Take by weighing Fructus Chebulae 12g, JIANHUA 18g, Radix Et Rhizoma Rhei 40g, Herba chenopodii 15g, be ground into fine powder after the mixing jointly, mixing, the gelatine capsule of packing into promptly gets capsule.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
The preparation tablets of [embodiment 7] Tibetan medicine of the present invention:
Take by weighing Fructus Chebulae 7g, JIANHUA 9g, Radix Et Rhizoma Rhei 48g, Herba chenopodii 21g, be ground into fine powder after the mixing jointly, mixing adds adjuvant and processes granule, dry below 60 ℃, and granulate, tabletting promptly gets tablet.
Usage and dosage is: oral; A 4～5g, 2～4 times on the one.
Below come further to set forth the beneficial effect of Tibetan medicine of the present invention, these Test Example to comprise that the pharmacodynamics test of Tibetan medicine embodiment 1 of the present invention and clinical observation on the therapeutic effect test through Test Example.
Tests such as the defecation of [Test Example 1] Tibetan medicine embodiment 1 of the present invention, intestinal propulsion motion, large intestine ahead running, the influence of intestinal volume, functions of loosening bowel relieving constipation:
Test material: anthology invention Tibetan medicine embodiment 1; DAHUANG TONGBIAN JIAONANG is produced by Jianjiang Pharmaceutical Factory, batch number 20090704; India ink is produced by chemical plant in the west, Beijing, batch number 20090301; Compound diphenoxylate is produced by Jiaozuo City Kang Li Pharmaceutical limited company, batch number 20090724; Pentobarbital sodium, SERVA import packing, chemical plant product, batch number 20091019 are known in last sea-run; Kunming mouse, Wistar rat are provided by Qinghai Province's Experimental Animal Center.
Experimental technique: 1, the defecation of 1 pair of dryness accumulated in the stomach and intestine dehydration of Tibetan medicine embodiment of the present invention constipation model mice test: get body weight 24～26g healthy mice; Male and female half and half; Be divided into 6 groups at random by body weight; If blank group, model control group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and Tibetan medicine embodiment 1 of the present invention (2g/kg, 4g/kg, 8g/kg) basic, normal, high dose groups.Except that the blank group, other are respectively organized mice and prohibit water non-fasting 72h, cause dryness accumulated in the stomach and intestine dehydration constipation model.The blank group is irritated stomach and is given the 2% india ink suspension that is configured to distilled water; The administration group is then irritated the 2% india ink suspension that stomach gives to replace with medicinal liquid distilled water; Administration volume 1mL/20g body weight is put into the mice box with mice after the administration, 1 in every box; The clean filter paper of underlay white, every mice of observed and recorded are discharged the time (min) of melena and the melena sum that the interior mice of 4h is discharged first.The significance of each group difference of t check, the result sees table 1.
2, the defecation of 1 pair of compound diphenoxylate of Tibetan medicine embodiment of the present invention (DC) model mice test: animal and grouping are with 1; Each is organized mice and prohibits water non-fasting 12h; Except that the blank group was given the equivalent distilled water, all the other each groups were irritated stomach and are given compound diphenoxylate (DC) suspension 50mg/kg.Behind the 30min, each treated animal is irritated stomach and is received the reagent thing, administration volume 1mL/20g body weight, and blank group and model control group are given the equivalent distilled water.The argol that every group of mice of observed and recorded discharged is counted, loose stool is counted and the number of animals of defecation not, observes 12h continuously, respectively organizes index, the significance of each group difference of t check, and the result sees table 2.
3, the defecation of 1 pair of normal mouse of Tibetan medicine embodiment of the present invention test: get body weight 24～26g healthy mice; Male and female half and half; Be divided into 5 groups at random by body weight; If blank group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and Tibetan medicine embodiment 1 of the present invention (2g/kg, 4g/kg, 8g/kg) basic, normal, high dose groups.The blank group is irritated stomach and is given the 2% india ink suspension that is configured to distilled water, and the administration group is then irritated stomach and given the 2% india ink suspension that replaces distilled water to be configured to medicinal liquid, and the administration volume is the 1mL/20g body weight.After the administration mice is put into the mice box, 1 in every box, the clean filter paper of underlay white, every mice of observed and recorded is discharged the time (min) of melena and the sum that the interior mice of 4h is discharged melena first.The significance of each group difference of t check, the result sees table 3.
4, the 1 pair of mouse small intestine ahead running of Tibetan medicine embodiment of the present invention test: animal and dividing into groups with 3 is a mark with the carbon ink, and the blank group is irritated stomach and given the 7% carbon ink suspension that is configured to normal saline; The administration group is then irritated stomach and is given the 7% carbon ink suspension that replaces distilled water to be configured to medicinal liquid, and the administration volume is the 0.4mL/20g body weight, irritates 30min behind the stomach; Mice is put to death in the cervical vertebra dislocation; The taking-up gastrointestinal of cutting open the belly immediately is tiled on the glass plate, measures displacement and the small intestinal total length of carbon ink head end in intestinal tube (from pylorus to ileum); Calculate and advance percentage rate, the distance of carbon ink propelling rate=carbon ink front end and pylorus/small intestinal total length * 100%.The significance of each group difference of t check, the result sees table 4.
5,1 pair of rat large intestine of Tibetan medicine embodiment of the present invention ahead running test: get body weight 250～350g healthy adult rat; All male; Be divided into 5 groups at random by body weight; If blank group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and Tibetan medicine embodiment 1 of the present invention (2g/kg, 4g/kg, 8g/kg) basic, normal, high dose groups.Anesthetized rat during experiment, abdominal part cropping then along the median line otch, is opened the abdominal cavity and is found caecum and colon junction.Blank group rat is injected the normal saline that contains 10% india ink in this one in colonic lumen, the administration group is then injected the medicinal liquid that contains 10% india ink, administration volume 2.5mL/kg body weight.5min after the administration opens the abdominal cavity immediately, separates and cuts large intestine, takes out, and pendulum is straight naturally, measures large intestine length and the propulsive distance of prepared Chinese ink with meter ruler, calculates the propelling percentage rate, carbon ink propelling rate=carbon ink advance distance/large intestine total length * 100%.The significance of each group difference of t check, the result sees table 5.
6,1 pair of mice intestinal of Tibetan medicine embodiment of the present invention volume influence test: animal and grouping are with 3, and after water 12h was can't help in fasting, each organized gastric infusion according to dosage, and the blank group is given equivalent distilled water, administration volume 1mL/20g body weight.Behind the administration 2.5h the disconnected cervical vertebra of animal is put to death, cut off the abdominal cavity, expose intestinal tube; In pylorus lower end and ileocecus ligation, the place cuts intestinal tube from pylorus, carefully cuts mesentery with little shears downwards along intestinal tube; Cut off intestinal tube at ileocecus, accurate weighing intestinal tube weight on electronic balance.The significance of each group difference of t check, the result sees table 6.
7,1 pair of mice functions of loosening bowel relieving constipation experiment of Tibetan medicine embodiment of the present invention: animal and grouping are with 3, and each organizes gastric infusion according to dosage, and the blank group is given equivalent distilled water, administration volume 1mL/20g body weight.After the administration mice is put into the mice box, 1 in every box, the clean filter paper of underlay white the time and the character of soft stool, loose stool, loose stool occurs the 1st time in the record 4h, represents purging and intestine lubricating action with soft stool, represents defecating feces excretion with loose stool, represents discharge function with loose stool.Soft stool refers to that excrement is shaped, but softly expands that to contain moisture more, and loose stool slightly is shaped or is shapeless, scattered paste shape, loose stool scattered paste shape or water liquid.The significance of each group difference of t check, the result sees table 7.
Experimental result: 1, table 1 is seen in the influence of 1 pair of dryness accumulated in the stomach and intestine dehydration of Tibetan medicine embodiment of the present invention constipation model mice defecation.
The influence of 1 pair of dryness accumulated in the stomach and intestine dehydration of table 1 Tibetan medicine embodiment of the present invention constipation model mice defecation (x ± s, n=10)
Group number of animals dosage (g/kg) is arranged the interior row of melena time (min) 4h melena first and is counted
Blank group 10 191.8 ± 77.6
2.4 ± 1.6
Model control group 10 356.1 ± 16.7
#0.2 ± 0.7
#
Positive controls 10 0.5 323.6 ± 66.7 0.9 ± 1.6
Low dose group 10 2 335.1 ± 79.2 0.4 ± 1.4
Middle dose groups 10 4 266.2 ± 112.4
*1.7 ± 2.3
*
High dose group 10 8
229.3 ± 84.4
*2.8 ± 2.1
*
Explain: relatively with the blank group:
#P<0.01; With the model matched group relatively:
*P<0.05;
*P<o.0l.
2, table 2 is seen in the test of the defecation of 1 pair of compound diphenoxylate of Tibetan medicine embodiment of the present invention (DC) model mice.
The influence of 1 pair of DC constipation of table 2 Tibetan medicine embodiment of the present invention model mice defecation (x ± s, n=10)
Group number of animals dosage (g/kg) the argol loose stool not defecation number of animals of counting of counting
Blank group 10 8.1 ± 4.13 00
Model control group 10 2.3 ± 2.55
#00
Positive controls 10 0.5 3.6 ± 1.57 00
Low dose group 10 2 3.8 ± 3.24 0.2 ± 0.43 0
Middle dose groups 10 4 4.7 ± 2.48
*0.3 ± 0.47 0
High dose group 10 8 9.4 ± 3.28
*1.8 ± 1.95
*0
Explain: relatively with the blank group:
#P<0.01; With the model matched group relatively:
*P<0.05;
*P<o.0l.
3, table 3 is seen in the influence of 1 pair of normal mouse defecation of Tibetan medicine embodiment of the present invention.
The influence of 1 pair of normal mouse defecation of table 3 Tibetan medicine embodiment of the present invention (x ± s, n=10)
Group number of animals dosage (g/kg) is arranged the interior row of melena time (min) 4h melena first and is counted
Blank group 10 149.7 ± 744.7 2.2 ± 2.16
Positive controls 10 0.5 116.8 ± 42.3 6.9 ± 2.37
*
Low dose group 10 2 138.7 ± 65.4 4.1 ± 1.94
Middle dose groups 10 4 110.8 ± 55.6
5.6 ± 3.28
*
High dose group 10 8 93.4 ± 49.3
*8.3 ± 2.17
*
Explain: relatively with the model matched group:
*P<0.05;
*P<o.0l.
4, table 4 is seen in 1 pair of propulsive influence of small intestine movement of mice of Tibetan medicine embodiment of the present invention.
1 pair of propulsive influence of small intestine movement of mice of table 4 Tibetan medicine embodiment of the present invention (x ± s, n=10)
Group number of animals dosage (g/kg) small intestinal length (cm) carbon ink advance distance (cm) advances percentage rate (%)
Blank group 10 51.8 ± 2.28 39.4 ± 3.66 76.14 ± 6.55
Positive controls 10 0.5 48.1 ± 4.53 43.3 ± 6.37 90.04 ± 10.66
*
Low dose group 10 2 47.5 ± 6.37 36.4 ± 6.97 77.34 ± 9.04
Middle dose groups 10 4 49.3 ± 3.72 42.7 ± 6.37 86.47 ± 9.83
*
High dose group 10 8 49.1 ± 5.36 46.1 ± 5.28
*94.05 ± 6.56
*
Explain: relatively with the model matched group:
*P<0.05;
*P<o.0l.
5, table 5 is seen in 1 pair of propulsive influence of normal rat large intestine of Tibetan medicine embodiment of the present invention.
1 pair of propulsive influence of normal rat large intestine of table 5 Tibetan medicine embodiment of the present invention (x ± s, n=10)
Group number of animals dosage (g/kg) large intestine length (cm) carbon ink advance distance (cm) advances percentage rate (%)
Blank group 10 15.4 ± 1.4 5.8 ± 2.3 37.4 ± 15.5
Positive controls 10 0.5 14.8 ± 0.7 7.7 ± 4.1 52.2 ± 27.1
*
Low dose group 10 2 15.5 ± 1.2 9.2 ± 4.4
*58.4 ± 25.6
*
Middle dose groups 10 4 15.2 ± 0.8 9.3 ± 3.7
*61.2 ± 22.4
*
High dose group 10 8 15.3 ± 1.1 11.1 ± 2.4
*73.4 ± 19.3
*
Explain: relatively with the model matched group:
*P<0.05;
*P<o.0l.
6, table 6 is seen in 1 pair of volumetrical influence of mice intestinal of Tibetan medicine embodiment of the present invention.
1 pair of volumetrical influence of mice intestinal of table 6 Tibetan medicine embodiment of the present invention (x ± s, n=10)
Group number of animals dosage (g/kg) intestinal tube weight (g)
Blank group 10 1.26 ± 0.14
Positive controls 10 0.5 1.51 ± 0.37
Low dose group 10 2 1.42 ± 0.22
Middle dose groups 10 4 1.41 ± 0.14
*
High dose group 10 8 1.53 ± 0.23
*
Explain: relatively with the model matched group:
*P<0.05.
7, table 7 is seen in the influence of 1 pair of mice loosening bowel to relieve constipation of Tibetan medicine embodiment of the present invention.
The influence of 1 pair of mice loosening bowel to relieve constipation of table 7 Tibetan medicine embodiment of the present invention (x ± s, n=10)
Group number of animals dosage (g/kg) soft stool time (min) loose stool time (min) loose stool time (min)
Blank group 10 135.4 ± 10.4 240.0 240.0
Positive controls 10 0.5 52.6 ± 66.7 183.3 ± 91.8 240.0
Low dose group 10 2 53.5 ± 72.2 181.5 ± 96.2 240.0
Middle dose groups 10 4 35.6 ± 27.8
*126.3 ± 98.7
*202.2 ± 62.4
High dose group 10 8 28.5 ± 29.4
*131.1 ± 96.4
*173.4 ± 109.3
Explain: relatively with the model matched group:
*P<0.05;
*P<o.0l.
The result shows: the time that Tibetan medicine embodiment 1 middle and high dosage of the present invention can make dryness accumulated in the stomach and intestine dehydration constipation model mice discharge melena first shortens; The total argol of discharge melena color dot is counted and is increased in the mice 4h; The number of animals of defecation does not reduce; High dose can make the argol of discharging in the DC constipation model mice 12h count to increase, and loose stool is counted and increased, and the number of animals of defecation reduces; Compare with model control group, its difference all has statistical significance.Dosage can make the interior melena color dot sum of discharging of normal mouse 4h increase among the Tibetan medicine embodiment 1 of the present invention; The time that high dose can make normal mouse discharge melena first shortens; Discharging melena color dot sum in the mice 4h increases; Compare with the blank group, its difference also has statistical significance, points out 1 pair of dryness accumulated in the stomach and intestine dehydration of Tibetan medicine embodiment of the present invention constipation model mice, DC constipation model mouse and normal mouse all to have and promotes the excretory discharge function of animal more significantly.Tibetan medicine embodiment 1 middle and high dosage of the present invention can promote mouse small intestine prepared Chinese ink advance distance; Tibetan medicine embodiment 1 basic, normal, high dosage of the present invention can promote rat large intestine prepared Chinese ink advance distance; Compare with the blank group; Its difference all has statistical significance, points out Tibetan medicine embodiment 1 of the present invention that the ahead running that promotes intact animal's small intestinal, large intestine is arranged, and strengthens the function of enterokinesia.Tibetan medicine embodiment 1 middle and high dosage of the present invention can obviously increase the mouse small intestine moisture; Mice intestinal tube weight is increased; It is big that the intestinal volume becomes, make mice soft stool, loose stool time occur and obviously shorten, with the blank group relatively; Its difference all has statistical significance, point out Tibetan medicine embodiment 1 of the present invention to have more significantly to reduce intestinal to moisture absorption, make the remollescent functions of loosening bowel relieving constipation of stool.Above result shows that Tibetan medicine embodiment 1 of the present invention has stronger promotion animal defecation, increases enterokinesia and functions of loosening bowel relieving constipation, therefore, clinically constipation is had certain value.
The clinical observation on the therapeutic effect of [Test Example 2] Tibetan medicine embodiment 1 treatment constipation of the present invention:
Physical data: constipation patient is totally 120 examples, is divided into two groups at random by digital method, and 60 examples are organized in treatment, male 36 examples, women 24 examples, 54.5 years old mean age; Matched group 60 examples, male 38 examples, women 22 examples, 55 years old mean age.The age of two groups of cases, sex and physical data difference not statistically significant.
Diagnostic criteria: according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", defecation time prolongs, and two days with the last time, the feces dry, hard; Weight person's difficulty in defecation, dry as chestnut can accompany few abdominal distention anxious, and is refreshing tired weak, and the stomach poor appetite such as moves back at disease.
Exclusion standard: get rid of the intestinal organic disease.
Therapeutic Method: 1, treatment group: adopt Tibetan medicine embodiment 1 of the present invention, put in the 150ml water and decoct, during decocting to 1/3, taking liquid is drunk; A 5g, 2～4 times on the one.
2, matched group: DAHUANG TONGBIAN JIAONANG, 0.9g/ time, 1 day 1 time, the preceding warm water delivery service of sleeping evening.
Two groups is 1 course of treatment to treat 15 days all, finishes the statistics therapeutic outcome 1 course of treatment.
Clinical efficacy evaluation criteria: according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ", cure: just matter was changeed profit with interior defecation 1 time in 2 days, and unobstructed when separating, short-term does not have recurrence; Take a turn for the better: just matter was changeed profit with interior defecation in 3 days, and it is smooth that defecation is owed; Do not heal: symptom does not have improvement.
Healing adding improvement and adding up to total effective rate.
Clinical observation result is seen table 8.
Table 8 liang group efficacy of antihypertensive treatment comparison (example, %)
Group example number is cured the more total effective rate that takes a turn for the better not
Treatment organizes 60 41 17 2 96.67
*
Matched group 60 37 18 5 91.67
Annotate: compare with matched group
*P<0.05.
Untoward reaction: have no adverse reaction in two groups of therapeutic processes; The check hepatic and renal function was all normal after finished two groups of courses of treatment.
Clinical observation result shows: Tibetan medicine embodiment 1 treatment constipation determined curative effect of the present invention, and be worth clinical expansion to use, have certain application prospect.
Claims (8)
1. Tibetan medicine of treating constipation; It is characterized in that it is made up of active component or is made up of active component and acceptable accessories, wherein said active component is to be processed by following bulk drugs: Fructus Chebulae 5～20g, JIANHUA 7～30g, Radix Et Rhizoma Rhei 15～60g, Herba chenopodii 15～60g.
2. Tibetan medicine according to claim 1, wherein said active component are to be processed by following bulk drugs: Fructus Chebulae 10g, JIANHUA 15g, Radix Et Rhizoma Rhei 30g, Herba chenopodii 30g.
3. Tibetan medicine according to claim 1 and 2, it is a peroral dosage form.
4. Tibetan medicine according to claim 3, it is decoction pulvis, medicinal tea, powder, pill, granule, capsule or tablet.
5. the method for preparing of the said Tibetan medicine of claim 1, it comprises the following steps: to take by weighing the raw material of following weight portion: Fructus Chebulae 5～20g, JIANHUA 7～30g, Radix Et Rhizoma Rhei 15～60g, Herba chenopodii 15～60g; Mix, be ground into fine powder then jointly, mixing is processed active component.
6. the method for preparing of the said Tibetan medicine of claim 1, it comprises the following steps: to take by weighing the raw material of following weight portion: Fructus Chebulae 5～20g, JIANHUA 7～30g, Radix Et Rhizoma Rhei 15～60g, Herba chenopodii 15～60g; Mix, adopt decoction and alcohol sedimentation technique or ethanol extract from water precipitation to process active component.
7. according to claim 5 or 6 described method for preparinies, wherein take by weighing the raw material of following weight portion: Fructus Chebulae 10g, JIANHUA 15g, Radix Et Rhizoma Rhei 30g, Herba chenopodii 30g.
8. according to claim 5,6 or 7 described method for preparinies, it also comprises the following steps: active component and acceptable accessories are processed decoction pulvis, medicinal tea, powder, pill, granule, capsule or tablet.
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| CN2012102403012A CN102716197A (en) | 2012-07-12 | 2012-07-12 | Tibetan medicine for treating constipation and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106387235A (en) * | 2016-11-24 | 2017-02-15 | 西宁志培知识产权咨询有限公司 | Method for preparing herbal tea with function of relieving intestinal dryness with constipation from food plants as components |
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| CN101700397A (en) * | 2009-11-10 | 2010-05-05 | 尼玛次仁 | Tibetan medicine composite for treating diabetes and preparation method of preparation thereof |
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| CN101269198A (en) * | 2008-02-29 | 2008-09-24 | 西藏嘉黎县藏医院 | Pure Chinese medicine preparation for preventing and treating enteron disease and improving self phylactic power, and preparation method thereof |
| CN101700397A (en) * | 2009-11-10 | 2010-05-05 | 尼玛次仁 | Tibetan medicine composite for treating diabetes and preparation method of preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106387235A (en) * | 2016-11-24 | 2017-02-15 | 西宁志培知识产权咨询有限公司 | Method for preparing herbal tea with function of relieving intestinal dryness with constipation from food plants as components |
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Application publication date: 20121010 |