CN115475198B

CN115475198B - Traditional Chinese medicine composition for treating constipation and preparation method thereof

Info

Publication number: CN115475198B
Application number: CN202211149631.0A
Authority: CN
Inventors: 解红霞
Original assignee: Individual
Current assignee: Xie Hongxia
Priority date: 2022-09-21
Filing date: 2022-09-21
Publication date: 2023-08-11
Anticipated expiration: 2042-09-21
Also published as: CN115475198A

Abstract

The invention provides a traditional Chinese medicine composition for treating constipation and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 50-85 parts of sausage fruit, 5-20 parts of bighead atractylodes rhizome, 3-20 parts of raw licorice, 2-10 parts of bunge cherry seed, 2-10 parts of black sesame and 2-10 parts of cistanche deserticola. The traditional Chinese medicine formula has the effects of clearing liver-fire, invigorating spleen, tonifying qi, purging viscera, purging heat, moistening intestines without damaging yin through scientific compatibility, and has obvious curative effects on constipation of children and senile constipation.

Description

Traditional Chinese medicine composition for treating constipation and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating constipation and a preparation method thereof.

Background

Constipation is a clinically common complex symptom, mainly referring to the reduction of defecation times, the reduction of fecal quantity, dry and hard feces, and the like. Constipation is not a disease, but can be seen in various diseases, seriously affects the life quality of people, and plays an important role in the occurrence of colon cancer, hepatic encephalopathy, breast diseases, alzheimer's disease and other diseases, so that the constipation can be prevented and reasonably treated in early stage, and the serious consequences and social burden caused by constipation can be greatly relieved.

At present, western medicines such as: phenolphthalein, castor oil, bisesterphenol, and the like, can cause colonic black stool or laxative colon after long-term application, cause contraction of smooth muscle and damage of interintestinal nerve plexus, rather aggravate constipation, and is reversible after stopping drug; or adopts fruit sugar to relieve constipation or adopts opening and closing to relieve, and has the defects of treating the symptoms, not treating the root cause, unstable curative effect, lower cure rate and the like. The traditional Chinese medicines are taken as raw materials, so that the toxic and side effects can be well avoided, but traditional Chinese medicine treatment generally adopts 'Dachengqi decoction', rhubarb, senna leaf, magnesium sulfate and the like to relieve constipation, and the traditional Chinese medicine is dry after relapse. Even though western medicines, traditional Chinese medicines and western medicines are combined to treat constipation, and a certain curative effect is achieved, some disadvantages still exist and cannot be applied. Therefore, intensive studies in the field of traditional Chinese medicine are necessary to solve this problem.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating constipation, which can effectively treat children constipation and senile constipation and has high safety.

In order to achieve the above object, the present invention provides the following technical solutions:

the invention provides a traditional Chinese medicine composition for treating constipation, which comprises the following raw materials in parts by weight: 50-85 parts of sausage fruit, 5-20 parts of bighead atractylodes rhizome, 3-20 parts of raw licorice, 2-10 parts of bunge cherry seed, 2-10 parts of black sesame and 2-10 parts of cistanche deserticola.

The invention also provides a preparation method of the traditional Chinese medicine composition for treating constipation, which comprises the following steps: weighing the traditional Chinese medicine composition according to the formula, grinding, sieving, adding water for decoction, filtering, and merging filtrate; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol, stirring, standing, filtering, concentrating under reduced pressure, and recovering ethanol to obtain the final product.

Preferably, the number of sieves is from 100 to 180 mesh.

Preferably, the number of times of water decoction is 2-3.

Preferably, the water ratio of the traditional Chinese medicine composition to the water is 1:2-4 when the traditional Chinese medicine composition is decocted in water.

Preferably, the water decoction time is 0.5-4 h.

Preferably, the mass concentration of the ethanol is 70-90%

Preferably, the condition of reduced pressure concentration is 0.05MPa to 0.08MPa,65 ℃ to 80 ℃.

The invention provides an application of the traditional Chinese medicine composition or the traditional Chinese medicine composition obtained by the preparation method in medicines for treating constipation of children and/or senile constipation.

Preferably, the dosage form of the medicament comprises clinically acceptable tablets, powder, granules, capsules or oral liquid.

Compared with the prior art, the invention has the following technical effects:

the traditional Chinese medicine composition disclosed by the invention takes the liver-fire clearing, qi tonifying and intestine moistening as a main treatment principle so as to achieve the purpose of treating both symptoms and root causes. In the formula, the sausage fruit is taken as a monarch drug, and has the effects of clearing heat, moistening intestines, relaxing bowels and removing stagnation; the bighead atractylodes rhizome is used as a ministerial drug and has the effects of activating spleen and promoting body fluid and relieving the bowels; the raw licorice and the bunge cherry seed are used as adjuvant drugs to play a role in improving the functions of the spleen and the stomach and treating the deficiency of the spleen and the stomach; semen Sesami Niger and herba cistanches are used as guiding drugs for resolving food stagnation, invigorating kidney, replenishing vital essence, loosening bowel and relieving constipation. The traditional Chinese medicine prescription is scientifically compatible, the combination of the medicines can effectively improve constipation, and the traditional Chinese medicine prescription has obvious curative effects on children constipation and senile constipation and high medication safety.

Detailed Description

The invention provides a traditional Chinese medicine composition for treating constipation, which comprises the following raw materials in parts by weight: 50-85 parts of sausage fruit, 5-20 parts of bighead atractylodes rhizome, 3-20 parts of raw licorice, 2-10 parts of bunge cherry seed, 2-10 parts of black sesame and 2-10 parts of cistanche deserticola. Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 60-80 parts of sausage fruit, 8-15 parts of bighead atractylodes rhizome, 6-10 parts of raw licorice, 5-8 parts of bunge cherry seed, 5-8 parts of black sesame and 5-8 parts of cistanche deserticola.

In the invention, the sausage fruit is the dried mature fruit of the leguminous plant, namely the Cansia ficula L, which has the effects of clearing liver heat, detoxication, detumescence and purgation; is used for treating hepatitis, liver poisoning, constipation, and limb swelling.

Bai Zhu is sweet and spicy in flavor, warm in nature, ascending and descending, yang and yin in middle energizer, and nontoxic. Enters the meridians of the heart, spleen, stomach, kidneys and triple energizer. Has effects in removing dampness, promoting digestion, invigorating qi, strengthening yin, and benefiting qi of waist and umbilicus. Is mainly used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration and fetal movement.

Sheng Lian Cao is neutral in nature and sweet in flavor, and enters heart, lung, spleen and stomach meridians. Has effects in invigorating spleen, replenishing qi, clearing away heat and toxic materials, eliminating phlegm, relieving cough, relieving spasm, relieving pain, and regulating the functions of the materials. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, palpitation, short breath, cough with excessive phlegm, abdominal pain, limb spasm, carbuncle, swelling, sore and toxic materials, and relieving drug toxicity and intensity.

Bunge cherry seed, with flat nature, pungent, bitter and sweet taste, enters spleen, large intestine and small intestine meridians. The main functions are as follows: moisten dryness and smooth the intestines, descend qi and induce diuresis. Can be used for treating dry and dry body fluid, food stagnation, abdominal distention, constipation, edema, tinea pedis, and dysuria. Has effects of moistening dryness, smoothing intestine, descending qi, promoting qi circulation, inducing diuresis and relieving edema.

Semen Sesami nigrum is dry mature seed of Sesamum indicum L. Has effects of nourishing liver and kidney, replenishing essence and blood, and moistening intestine and dryness. Can be used for treating dizziness, dim eyesight, tinnitus, deafness, premature gray hair, alopecia after illness, constipation due to intestinal dryness.

Cistanche salsa, sweet and salty in taste, warm in nature, enters kidney and large intestine meridians; the main functions are as follows: tonify kidney yang, nourish essence and blood, moisten intestine. Impotence due to deficiency of kidney-yang and deficiency of essence and blood; seminal emission, turbid urine, frequent urination, lumbago, weakness of feet, tinnitus and blurred vision; menstrual period; infertility due to cold womb; constipation due to intestinal dryness.

The Chinese medicinal composition has the effects of clearing heat, moistening intestines, relaxing bowels and removing stagnation by taking sausage fruits as monarch drugs in the formula; the bighead atractylodes rhizome is used as a ministerial drug and has the effects of activating spleen and promoting body fluid and relieving the bowels; the raw licorice and the bunge cherry seed are used as adjuvant drugs to play a role in improving the functions of the spleen and the stomach and treating the deficiency of the spleen and the stomach; semen Sesami Niger and herba cistanches are used as guiding drugs for resolving food stagnation, invigorating kidney, replenishing vital essence, loosening bowel and relieving constipation. The traditional Chinese medicine prescription is scientifically compatible, the combination of the medicines can effectively improve constipation, and the traditional Chinese medicine prescription has obvious curative effects on children constipation and senile constipation and high medication safety.

The invention provides a preparation method of a traditional Chinese medicine composition for treating constipation, which comprises the following steps: weighing the traditional Chinese medicine composition according to the formula, grinding, sieving, adding water for decoction, filtering, and merging filtrate; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol, stirring, standing, filtering, concentrating under reduced pressure, and recovering ethanol to obtain the final product. The method and the equipment for grinding and sieving are not particularly limited, and the traditional Chinese medicine grinding and sieving method and the equipment which are conventional in the field are adopted.

In the invention, the sieving number is 100-180 meshes; preferably, the number of sieves is 120-160 mesh; more preferably 150 mesh.

In the invention, the times of water decoction are 2-3 times. In the invention, the effective components in the traditional Chinese medicine can be fully dissolved by decoction, which is beneficial to the effective components to exert the efficacy.

In the invention, the ratio of the traditional Chinese medicine composition to the water is 1:2-4 when the traditional Chinese medicine composition is decocted in water.

In the invention, the water decoction time is 0.5-4 h. In the invention, as an implementation mode, the time for the first water decoction of the traditional Chinese medicine composition is 2-4 hours; the second time of water decoction of the traditional Chinese medicine composition is 0.5-2 h; the third time of water decoction time of the traditional Chinese medicine composition is 0.5-1 h. The invention adopts three times of decoction, which is favorable for dissolving out the effective components of the traditional Chinese medicine and is favorable for the mutual fusion of the effective components of the traditional Chinese medicine.

In the present invention, the mass concentration of the ethanol is 70 to 90%. Preferably, the concentration of the ethanol is 75-85%. The concentration of ethanol used in the invention is more beneficial to the dissolution and retention of micromolecular effective components in the traditional Chinese medicine, reduces the loss of trace elements and enhances the pharmacological activity of the effective components in the traditional Chinese medicine.

In the invention, the conditions of reduced pressure concentration are 0.05MPa to 0.08MPa and 65 ℃ to 80 ℃. Preferably, the reduced pressure concentration condition is 0.06 MPa-0.07 MPa, 68-75 ℃. In the present invention, the conditions for the concentration under reduced pressure are both within the above-mentioned ranges. The invention adopts reduced pressure concentration to further promote the dissolution of the effective components, is beneficial to the extraction of the thermosensitive effective components, and effectively shortens the time.

The invention provides an application of the traditional Chinese medicine composition or the traditional Chinese medicine composition obtained by the preparation method in medicines for treating constipation of children and/or senile constipation. In the invention, the traditional Chinese medicine composition can effectively treat constipation of children caused by intestinal flora imbalance, intestinal dysfunction, weakness of spleen and stomach and other reasons.

In the invention, the dosage forms of the medicine comprise clinically acceptable tablets, powder, granules, capsules or oral liquid. In the invention, as an implementation mode, the traditional Chinese medicine composition is prepared into capsules by adding auxiliary materials after spray drying and dry granulating; as an implementation mode, the traditional Chinese medicine composition can be prepared into an oral preparation by adding auxiliary materials; as an implementation mode, the traditional Chinese medicine composition is subjected to spray drying, added with auxiliary materials, soaked by 70-85% ethanol to prepare a soft material, sieved and dried to obtain granules; as an implementation mode, the traditional Chinese medicine composition is subjected to spray drying, added with auxiliary materials, soaked by 70-85% ethanol, made into a soft material, and subjected to sieving, granulating, drying, tabletting and sugar coating to obtain the tablet. The spray drying and dry granulation are all well known to those skilled in the art; such excipients include, but are not limited to, starches, dextrins, powdered sugar, sucrose.

The technical solutions of the present invention will be clearly and completely described in the following in connection with the embodiments of the present invention. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Example 1

A traditional Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 80 parts of sausage fruit, 10 parts of bighead atractylodes rhizome, 4 parts of raw licorice, 2 parts of bunge cherry seed, 2 parts of black sesame and 2 parts of cistanche deserticola.

Example 2

A traditional Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 50 parts of sausage fruit, 20 parts of bighead atractylodes rhizome, 12 parts of raw licorice, 8 parts of bunge cherry seed, 5 parts of black sesame and 5 parts of cistanche deserticola.

Example 3

A traditional Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 85 parts of sausage fruit, 5 parts of bighead atractylodes rhizome, 3 parts of raw licorice, 2 parts of bunge cherry seed, 2 parts of black sesame and 3 parts of cistanche deserticola.

Example 4

A preparation method of a traditional Chinese medicine composition for treating constipation comprises the following steps: weighing the traditional Chinese medicine composition according to the formula of the embodiment 1, grinding, sieving with a 150-mesh sieve, adding 3 times of volume of water, decocting for three times, wherein the first time is 3 hours, the second time is 1 hour, the third time is 0.5 hour, and merging decoctions; concentrating under reduced pressure at 70deg.C and 0.06MPa to obtain extract, adding 75% ethanol, stirring, standing, filtering, concentrating the filtrate under reduced pressure at 70deg.C and 0.06MPa to obtain concentrated solution, recovering ethanol, filtering the concentrated solution, and adding sucrose to obtain oral preparation.

Example 5

Unlike example 4, the components were weighed according to the raw material ratios described in example 2, with the remaining steps unchanged.

Example 6

Unlike example 4, the components were weighed according to the raw material ratios described in example 3, and the remaining steps were unchanged.

Example 7

Unlike example 4, the number of sieves was 100 mesh, and the rest of the steps were unchanged.

Example 8

Unlike example 4, the number of sieves was 180 mesh, and the rest of the steps were unchanged.

Example 9

Unlike example 4, the conditions for the reduced pressure concentration were 0.05MPa,65℃and the rest of the steps were unchanged.

Example 10

Unlike example 4, the conditions for the reduced pressure concentration were 0.08MPa,80℃and the rest of the steps were unchanged.

Example 11

Unlike example 4, the ethanol mass concentration was 70% with the remaining steps unchanged.

Example 12

Unlike example 4, the ethanol mass concentration was 90% with the remaining steps unchanged.

EXAMPLE 13 use of the oral dosage form of example 4 of the present invention for treating constipation

200 constipation patients were selected and randomly divided into 50 patients in treatment 1, 50 patients in treatment 2, 50 patients in treatment 3 and 50 patients in control. The average age was 55 years. The age, sex and general data comparison differences of the two groups of cases have no statistical significance.

Diagnostic criteria: according to the traditional Chinese medicine disease diagnosis curative effect standard, the defecation time is prolonged, and the excrement is dry and hard once more than two days; the serious people have difficult stool, and dry, such as chestnut, can be accompanied with symptoms of less abdominal distention, lassitude, hypodynamia, hypogastrium and the like.

The treatment method comprises the following steps:

treatment 1 group: the oral preparation of the example 4 is orally taken, 15ml each time, 2 times a day, 20 days is a treatment course;

treatment group 2: the oral preparation of the example 5 is orally taken, 15ml each time, 2 times a day, 20 days is a treatment course;

treatment 3 groups: the oral preparation of the example 6 is orally taken, 15ml each time, 2 times a day, 20 days is a treatment course;

control group: castor oil is orally taken, 15ml each time, 2 times a day, 20 days as a treatment course.

Curative effect judgment standard:

the effect is shown: defecation is carried out for 1 time within 2 days, the stool is smooth, smooth in dissolving and free of recurrence in a short period;

the method is effective: defecation is carried out within 3 days, the stool is smooth, and the defecation is unsmooth;

invalidation: the symptoms are not improved.

Table 1 clinical effects after 1 course of treatment

By conducting clinical trials on the oral agents of the present invention, it can be seen from table 1: the oral preparation of the invention in the examples 4-6 has remarkable effect of treating constipation, and the effective rate is up to 96%.

Typical cases:

li Mou: the patient has constipation for 5 years after the age of 52 years, the defecation frequency is obviously reduced, and 1 defecation is performed every 2-3 days; in severe cases, 1 time is performed after 2-3 weeks. By taking the oral preparation of the embodiment 4 of the invention for 1 day for 2 times, 15ml each time, after taking 3 treatment courses, the defecation condition is gradually improved, and the defecation can be kept for 4-5 times per week.

Liu Mou: the patient is 6 years old, the defecation frequency is low, and the dry feces are not easy to discharge. By taking the oral preparation in the embodiment 4 of the invention for 1 time and 2 times a day, after taking 5ml each time and 1 treatment course, the excrement can be kept moist after 1 time of defecation every day, and the excrement is smooth.

The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating constipation is characterized by comprising the following raw materials in parts by weight: 50-85 parts of sausage fruit, 5-20 parts of bighead atractylodes rhizome, 3-20 parts of raw licorice, 2-10 parts of bunge cherry seed, 2-10 parts of black sesame and 2-10 parts of cistanche;

the preparation method of the traditional Chinese medicine composition for treating constipation comprises the following steps: weighing the traditional Chinese medicine composition, grinding, sieving, decocting in water, filtering, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol, stirring, standing, filtering, concentrating under reduced pressure, and recovering ethanol to obtain Chinese medicinal composition; the sieving number is 100-180 meshes; the condition of reduced pressure concentration is 0.05 MPa-0.08 MPa, 65-80 ℃.

2. The preparation method of the traditional Chinese medicine composition for treating constipation is characterized by comprising the following steps: weighing the traditional Chinese medicine composition according to claim 1, grinding, sieving, decocting in water, filtering, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol, stirring, standing, filtering, concentrating under reduced pressure, and recovering ethanol to obtain Chinese medicinal composition;

the sieving number is 100-180 meshes;

the condition of reduced pressure concentration is 0.05 MPa-0.08 MPa, 65-80 ℃.

3. The preparation method according to claim 2, wherein the number of times of water decoction is 2 to 3.

4. The method according to claim 3, wherein the water ratio of the Chinese medicinal composition to the water is 1:2-4.

5. The method according to claim 3, wherein the water-decocting time is 0.5 to 4 hours.

6. The preparation method according to claim 2, wherein the mass concentration of the ethanol is 70-90%.

7. The use of the traditional Chinese medicine composition according to claim 1 or the traditional Chinese medicine composition obtained by the preparation method according to any one of claims 2 to 6 in preparing a medicament for treating constipation of children and/or senile constipation.

8. The use according to claim 7, wherein the pharmaceutical dosage form comprises a clinically acceptable tablet, powder, granule, capsule or oral liquid.