CN115252700A - Traditional Chinese medicine composition and medicine for treating cervicogenic tinnitus and preparation method thereof - Google Patents

Traditional Chinese medicine composition and medicine for treating cervicogenic tinnitus and preparation method thereof Download PDF

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CN115252700A
CN115252700A CN202210893460.6A CN202210893460A CN115252700A CN 115252700 A CN115252700 A CN 115252700A CN 202210893460 A CN202210893460 A CN 202210893460A CN 115252700 A CN115252700 A CN 115252700A
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tinnitus
cervicogenic
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CN115252700B (en
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杨嘉恩
谢婉婷
谭淑仪
周光进
胡敏瑶
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Foshan City Gaoming District People's Hospital
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Abstract

The invention discloses a traditional Chinese medicine composition and a medicine for treating cervicogenic tinnitus and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises astragalus, ginseng, fructus viticis, ligusticum wallichii, rhizoma cimicifugae, cortex phellodendri, spina date seed, prepared rehmannia root, cistanche, rhizoma drynariae, epimedium herb, angelica sinensis, caulis spatholobi, radish seed, pangolin, magnetite and liquorice, and the traditional Chinese medicine composition can treat both symptoms and root causes of the cervicogenic tinnitus caused by liver-kidney deficiency and blood stasis blocking collaterals through interaction of the medicinal materials.

Description

Traditional Chinese medicine composition and medicine for treating cervicogenic tinnitus and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a medicine for treating cervicogenic tinnitus and a preparation method thereof.
Background
Tinnitus refers to the condition that there is no external sound source or stimulation, but the patient has a subjective sensation of sound in the ear or in the cranium, and may occur simultaneously on one side or both sides, or the patient feels that the sound comes from the cranium, so it is called "cranium sound, brain sound", and there are different names of chairing, bitter sound, cicada sound, etc. in ancient books of traditional Chinese medicine.
With the development of socioeconomic and the increase of working and living pressure, the incidence rate of tinnitus gradually increases, more and more people suffer from tinnitus, and the quality of life of patients is seriously affected by the emotions such as hearing loss, tension, insomnia, anxiety, depression and the like caused by the tinnitus. Tinnitus is associated with many different causes, such as hearing loss and noise impairment, emotional stress, etc., which lead to the appearance of tinnitus, and may also be associated with cervical spondylosis. The cervicogenic tinnitus is caused by the acute and chronic injury or degeneration of cervical vertebra, so that the internal and external mechanical balance of the cervical vertebra is disordered, then cervical sympathetic nerves or vertebral artery are stimulated, so that the vertebral-basilar artery blood supply insufficiency or spasm stenosis and the inner ear blood circulation disorder are caused. The cervicogenic tinnitus is in the junction area of the otolaryngological department and the rehabilitation department, so that the cervicogenic tinnitus is easy to be ignored clinically or is often misdiagnosed as the nervous tinnitus, and the illness state of a patient is delayed. Therefore, the establishment of effective and effective medicaments and methods for treating the cervicogenic tinnitus has important practical significance.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide a traditional Chinese medicine composition for treating the cervicogenic tinnitus, which can effectively treat the cervicogenic tinnitus and achieve the curative effect of treating both symptoms and root causes.
The invention also aims to provide a medicine for treating the cervicogenic tinnitus, which can effectively treat the cervicogenic tinnitus and achieve the curative effect of treating both symptoms and root causes.
The invention also aims to provide a preparation method of the medicine for treating the cervicogenic tinnitus, which is simple in preparation process and can be conveniently prepared into the medicine for treating the cervicogenic tinnitus.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating cervicogenic tinnitus comprises the following raw materials: radix astragali, radix Ginseng, fructus Vitics Simplicifoliae, rhizoma Chuanxiong, rhizoma cimicifugae, cortex Phellodendri, semen Ziziphi Spinosae, radix rehmanniae Preparata, herba cistanches, rhizoma Drynariae, herba Epimedii, radix Angelicae sinensis, caulis Spatholobi, semen Raphani, squama Manis, magnetitum, and radix Glycyrrhizae.
Further, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 15 to 20 portions of astragalus root, 10 to 15 portions of ginseng, 10 to 15 portions of chastetree fruit, 10 to 15 portions of Szechuan lovage rhizome, 10 to 15 portions of largetrifolioliolious bugbane rhizome, 10 to 15 portions of amur corktree bark, 10 to 15 portions of spina date seed, 10 to 15 portions of prepared rehmannia root, 10 to 15 portions of desertliving cistanche, 15 to 20 portions of fortune's drynaria rhizome, 15 to 20 portions of epimedium herb, 15 to 20 portions of Chinese angelica, 10 to 15 portions of suberect spatholobus stem, 15 to 20 portions of radish seed, 15 to 20 portions of pangolin scales, 15 to 20 portions of magnetite and 10 to 15 portions of liquoric root.
Further, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 10 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 20 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
Further, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 15 parts of astragalus, 10 parts of ginseng, 10 parts of fructus viticis, 15 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of epimedium herb, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 15 parts of radish seed, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
Further, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 15 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 15 parts of spina date seed, 15 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 15 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
The preparation method of the medicine for treating the cervicogenic tinnitus comprises the following steps of: weighing the raw materials according to the mass parts, uniformly mixing the raw materials, grinding or decocting the mixture with water, and preparing the mixture into an oral preparation to obtain the medicine for treating the cervicogenic tinnitus.
Further, weighing the raw materials according to the parts by weight, uniformly mixing the raw materials, decocting the raw materials with water to obtain decoction, concentrating the decoction into paste, adding auxiliary materials, and preparing the oral preparation.
A medicine for treating cervicogenic tinnitus is prepared by using the preparation method of the medicine for treating cervicogenic tinnitus.
Further, the medicine for treating the cervicogenic tinnitus is an oral preparation.
Further, the oral preparation is any one of decoction, pills, powder, granules, oral liquid, capsules and tablets.
The technical scheme has the following beneficial effects: the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises astragalus membranaceus, ginseng, fructus viticis, ligusticum wallichii, cimicifugae foetidae, golden cypress, spina date seed, prepared rehmannia root, cistanche deserticola, drynaria rhizome, epimedium herb, angelica sinensis, caulis spatholobi, radish seed, pangolin scales, magnetite and liquorice, can treat both symptoms and root causes of the cervicogenic tinnitus caused by liver and kidney deficiency and blood stasis and collateral obstruction, can dredge blood circulation disorder, improve blood supply of inner ear, enhance metabolism in ear, improve excitability of hair cells, nourish and activate cochlear nerve, and repair and regenerate ear cells. The traditional Chinese medicine composition contains astragalus, ginseng, rhizoma cimicifugae, radix rehmanniae preparata, herba cistanche and herba epimedii, and has the effects of nourishing kidney and tonifying kidney and improving immunity; rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, caulis Spatholobi, and semen Ziziphi Spinosae have effects of promoting blood circulation, removing blood stasis, dredging collaterals, and activating qi-flowing; fructus Vitics Simplicifoliae, raphani semen and cortex Phellodendri have effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substances; the drynaria rhizome, the pangolin scales and the magnetite have the effects of relieving tinnitus and convulsion, the effects of treating deafness and tinnitus, improving capillary microcirculation, enhancing liver and kidney functions, improving body immunity and the like are achieved by matching a plurality of medicinal materials, the holistic concept and advantages of the traditional Chinese medicine are fully embodied, the medicine effect and the function are more comprehensive, the symptoms and root causes are treated, and the specific content and the application range of dialectical treatment of the traditional Chinese medicine are expanded.
Detailed Description
The technical solution of the present invention will be further described with reference to the following embodiments.
A traditional Chinese medicine composition for treating cervicogenic tinnitus comprises the following raw materials: radix astragali, radix Ginseng, fructus Vitics Simplicifoliae, rhizoma Chuanxiong, rhizoma cimicifugae, cortex Phellodendri, semen Ziziphi Spinosae, radix rehmanniae Preparata, herba cistanches, rhizoma Drynariae, herba Epimedii, radix Angelicae sinensis, caulis Spatholobi, semen Raphani, squama Manis, magnetitum, and radix Glycyrrhizae.
The cervicogenic tinnitus is caused by disorder of internal and external mechanical balance of cervical vertebra due to acute and chronic injury or degeneration of the cervical vertebra, then cervical sympathetic nerve or vertebral artery is stimulated to cause vertebrobasilar artery blood supply insufficiency or spasm stenosis, and blood circulation disorder of inner ear, the cervicogenic tinnitus is better developed in middle-aged and elderly people, and is often accompanied with symptoms of cervicodynia, headache, dizziness and the like except the tinnitus, and the pathogenesis of the traditional Chinese medicine is 'liver and kidney deficiency and blood stasis obstruction of collaterals'. Because the cervicogenic tinnitus is in the junction area of the otolaryngological department and the rehabilitation department, and is easy to be ignored clinically or is often misdiagnosed as the neurogenic tinnitus, and the condition of a patient is delayed, the preparation of the medicament and the method for effectively treating the cervicogenic tinnitus have important practical significance.
The traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises astragalus mongholicus, ginseng, fructus viticis, ligusticum wallichii, rhizoma cimicifugae, cortex phellodendri, spina date seeds, prepared rehmannia roots, cistanche, rhizoma drynariae, herba epimedii, angelica sinensis, caulis spatholobi, semen raphani, pangolin scales, magnetite and liquorice, and can treat both symptoms and root causes of the cervicogenic tinnitus caused by liver and kidney deficiency and blood stasis and collateral obstruction, and simultaneously can dredge blood circulation disorder, improve blood supply of inner ears, enhance metabolism in ears, improve excitability of hair cells, nourish and activate cochlear nerves, so that ear cells can be repaired and regenerated. The traditional Chinese medicine composition contains astragalus, ginseng, rhizoma cimicifugae, radix rehmanniae preparata, herba cistanche and herba epimedii, and has the effects of nourishing kidney and tonifying kidney and improving immunity; rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, caulis Spatholobi, and semen Ziziphi Spinosae have effects of promoting blood circulation, removing blood stasis, dredging collaterals, and activating qi-flowing; fructus Vitics Simplicifoliae, raphani semen and cortex Phellodendri have effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substance; the drynaria rhizome, the pangolin scales and the magnetite have the effects of relieving tinnitus and convulsion, the effects of treating deafness and tinnitus, improving capillary microcirculation, enhancing liver and kidney functions, improving body immunity and the like are achieved by matching a plurality of medicinal materials, the holistic concept and advantages of the traditional Chinese medicine are fully embodied, the medicine effect and the function are more comprehensive, the symptoms and root causes are treated, and the specific content and the application range of dialectical treatment of the traditional Chinese medicine are expanded.
Further, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 15 to 20 portions of astragalus root, 10 to 15 portions of ginseng, 10 to 15 portions of chastetree fruit, 10 to 15 portions of Szechuan lovage rhizome, 10 to 15 portions of largetrifoliolious bugbane rhizome, 10 to 15 portions of amur corktree bark, 10 to 15 portions of spina date seed, 10 to 15 portions of prepared rehmannia root, 10 to 15 portions of desertliving cistanche, 15 to 20 portions of fortune's drynaria rhizome, 15 to 20 portions of epimedium herb, 15 to 20 portions of Chinese angelica, 10 to 15 portions of suberect spatholobus stem, 15 to 20 portions of radish seed, 15 to 20 portions of pangolin scales, 15 to 20 portions of magnetite and 10 to 15 portions of liquoric root.
It is worth stating that the traditional Chinese medicine etiology and pathogenesis of the cervicogenic tinnitus is 'liver and kidney deficiency, blood stasis blocking collaterals', and the quasi-Fang Zhize is 'tonifying liver and kidney, activating blood and dissolving stasis', and the appropriate mass part can be selected according to the age, constitution, course and specific state of the patient when in administration, wherein if the patient is more emphasized than the symptoms of liver and kidney deficiency, the mass parts of astragalus, ginseng, prepared rehmannia root, cistanche, spina date seed, epimedium herb and the like can be properly increased; for the symptoms of blood stasis and collateral obstruction, the mass parts of rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, caulis Spatholobi, squama Manis, and rhizoma Drynariae can be increased.
It is worth to explain that the pharmacological actions of the components of the traditional Chinese medicine composition for treating the cervicogenic tinnitus in the technical scheme are as follows:
radix astragali has effects of invigorating qi, invigorating yang, benefiting wei-defensive qi, consolidating superficial resistance, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, activating stagnancy, and relieving arthralgia, and radix astragali water decoction, polysaccharide, and saponin have protection and promotion effects on hemopoiesis function.
The ginseng contains ginsenoside which can regulate nerve function, recover the nerve process which is disordered due to tension, and has the effects of greatly reinforcing primordial qi, recovering pulse, relieving depletion, tonifying spleen, benefiting lung, promoting fluid production and nourishing blood.
The pungent flavor of fructus Viticis can dispel wind, clear heat with slight cold, float up gently, and is mainly to clear head and eyes and evacuate head and face pathogens.
The rhizoma Ligustici Chuanxiong has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain, and ligustrazine in rhizoma Ligustici Chuanxiong can reduce platelet surface activity, inhibit platelet aggregation, and prevent thrombosis.
Cimicifugae rhizoma has effects of relieving exterior syndrome, promoting eruption, clearing heat and detoxicating, and lifting yang qi, and cimicifugae rhizoma extract has effects of resisting inflammation, relieving pain, slowing heart rate, lowering blood pressure, and inhibiting platelet aggregation and release.
The cortex Phellodendri has effects of clearing heat, eliminating dampness, clearing pathogenic fire, removing toxic substances and removing bone and steam, and the cortex Phellodendri and berberine contained therein have remarkable effects of resisting inflammatory hyperplasia, resisting arrhythmia, lowering blood pressure, tranquilizing, reducing blood sugar, and resisting gout.
Semen Ziziphi Spinosae has effects of nourishing heart, nourishing liver, calming heart, tranquilizing mind, arresting sweating, and promoting fluid production, and semen Ziziphi Spinosae total saponin, total flavone, total alkaloids, and unsaturated fatty acid have effects of improving myocardial ischemia, improving anoxia resistance, lowering blood pressure, reducing blood lipid, enhancing immunity, resisting blood platelet aggregation, and resisting tumor.
Radix rehmanniae Preparata has effects of replenishing blood, nourishing yin, replenishing essence, and replenishing marrow, and radix rehmanniae Preparata ethanol extract has effects of enhancing immunity, promoting blood coagulation and tonifying heart, and has effects of invigorating qi and blood together with Ginseng radix.
Cistanchis herba has effects of invigorating kidney yang, replenishing essence and blood, loosening bowel to relieve constipation, and can be combined with herba Epimedii and radix Angelicae sinensis to enhance kidney and essence.
The dihydroflavonone glycoside in the rhizoma Drynariae has obvious effects of tranquilizing and relieving pain, promoting blood circulation, relieving pain, invigorating kidney and strengthening bone.
Herba Epimedii has effects of invigorating kidney, tonifying yang, strengthening tendons and bones, dispelling pathogenic wind, removing dampness, affecting functions of cardiovascular system, bone marrow and hemopoietic system, and resisting osteoporosis, radiation and tumor.
The angelica has the effects of enriching and activating blood, regulating menstruation, relieving pain and relaxing bowel, the angelica and the sodium ferulate thereof have obvious antithrombotic effect, and the angelica extract has the effects of expanding isolated guinea pig coronary arteries, increasing coronary blood flow and obviously protecting experimental myocardial ischemia.
Caulis Spatholobi has effects of promoting blood circulation, replenishing blood, regulating menstruation, relieving pain, relieving rigidity of muscles and activating collaterals, caulis Spatholobi total flavone and catechin compound in caulis Spatholobi have certain hemopoiesis function, caulis Spatholobi water extraction and alcohol precipitation liquid can increase experimental animal femoral artery blood flow, reduce vascular resistance and inhibit platelet aggregation, caulis Spatholobi water decoction can reduce animal cholesterol, and resist atherosclerosis pathological changes.
The semen Raphani has effects of resolving food stagnation, relieving flatulence, lowering qi, and eliminating phlegm, and can be used for enhancing rhythmic contraction of isolated rabbit ileum, inhibiting gastric emptying of mouse, eliminating phlegm, relieving cough, relieving asthma, improving urination function, reducing cholesterol, and preventing arteriosclerosis.
Squama Manis is excellent in property and moves scurrying, and has effects of promoting blood circulation, eliminating abdominal mass, dredging channels, promoting lactation, relieving swelling, expelling pus, dispelling pathogenic wind, and dredging collaterals, and its water decoction can significantly prolong blood coagulation time of mouse and rat, reduce blood viscosity, directly expand vascular wall, reduce peripheral resistance, and significantly increase femoral artery blood flow.
The Magnetitum has effects of relieving convulsion, tranquilizing mind, suppressing hyperactive liver, subsiding yang, improving hearing and eyesight, and promoting inspiration and relieving asthma, and also has effects of inhibiting central nerve, tranquilizing mind, hypnotizing and relieving convulsion, and the effect is remarkably enhanced after processing.
The liquorice has sweet taste, mild nature, sweet taste, can tonify deficiency, enter spleen and stomach channels, can tonify spleen and stomach deficiency to replenish middle-jiao energy, has sweet taste, slow and moderate effect, is used for treating acute and acute pain of abdominal spasm caused by spleen deficiency and liver hyperactivity, and glycyrrhizic acid and flavonoid substances are two main active ingredients of the liquorice for resisting ulcer, can reduce the tension of intestinal canals and reduce the contraction amplitude and have the spasmolysis effect.
In one technical scheme of the invention, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 10 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 20 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
In another technical scheme of the invention, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 15 parts of astragalus, 10 parts of ginseng, 10 parts of fructus viticis, 15 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of epimedium herb, 20 parts of angelica, 10 parts of caulis spatholobi, 15 parts of radish seed, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
In another technical scheme of the invention, the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 15 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 15 parts of spina date seed, 15 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 15 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
The preparation method of the medicine for treating the cervicogenic tinnitus comprises the following steps of: weighing the raw materials according to the mass parts, uniformly mixing the raw materials, grinding or decocting the raw materials with water, and preparing the mixture into an oral preparation to obtain the medicine for treating the cervicogenic tinnitus.
The preparation method of the medicine for treating the cervicogenic tinnitus in the technical scheme is simple and can be prepared according to the conventional method in the field.
Further, the raw materials are weighed according to the parts by weight, the raw materials are uniformly mixed and decocted in water to obtain decoction, the decoction is concentrated into paste, and auxiliary materials are added to prepare the oral preparation.
It is worth to say that the preparation method of the technical scheme can be used for concentrating the decoction liquid after water decoction into paste, adding auxiliary materials and processing into conventional oral preparations such as pills, granules, tablets, capsules, oral liquid and the like.
A medicine for treating cervicogenic tinnitus is prepared by the preparation method of the medicine for treating cervicogenic tinnitus.
Further, the medicine for treating the cervicogenic tinnitus is an oral preparation.
Further, the oral preparation is any one of decoction, pills, powder, granules, oral liquid, capsules and tablets.
Specifically, the medicine for treating the cervicogenic tinnitus can be prepared into any conventional oral preparation by adopting a conventional method of a traditional Chinese medicine preparation, for example, the raw material medicines of the traditional Chinese medicine composition can be ground into powder and uniformly mixed to prepare powder for taking, the raw material medicines can be decocted together with water and concentrated into decoction for taking, and meanwhile, the concentrated decoction obtained after decoction in water can be concentrated into paste to be processed into conventional oral preparations such as pills, granules, tablets, capsules, oral liquid and the like.
The medication method comprises the following steps: taking oral decoction as an example, 2 times per day (1 time for each morning and night), 250ml per time, ten days as a course of treatment, uncooked, spicy, greasy and irritating food is forbidden during the treatment period, and a moderate and mild cervicogenic tinnitus patient takes one course of treatment, so that symptoms can be obviously relieved, or tinnitus phenomenon disappears, and a severe tinnitus patient or deafness patient needs to take three to six courses of treatment, thereby effectively improving or completely curing without relapse.
The technical scheme of the invention is further illustrated by the following specific examples.
Example 1
The traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight (wherein 1 part is 1 g): 20 parts of astragalus membranaceus, 10 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 20 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
Example 2
The traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight (wherein 1 part is 1 g): 15 parts of astragalus, 10 parts of ginseng, 10 parts of fructus viticis, 15 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of epimedium herb, 20 parts of angelica, 10 parts of caulis spatholobi, 15 parts of radish seed, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
Example 3
The traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight (wherein 1 part is 1 g): 20 parts of astragalus membranaceus, 15 parts of ginseng, 15 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 15 parts of spina date seed, 15 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 15 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
Example 4
The traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight (wherein 1 part is 1 g): 18 parts of astragalus, 15 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 15 parts of rhizoma cimicifugae, 15 parts of cortex phellodendri, 13 parts of spina date seed, 10 parts of prepared rehmannia root, 15 parts of cistanche, 18 parts of rhizoma drynariae, 15 parts of herba epimedii, 15 parts of angelica sinensis, 15 parts of caulis spatholobi, 20 parts of semen raphani, 15 parts of pangolin, 15 parts of magnetite and 15 parts of liquorice.
Example 5
The traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight (wherein 1 part is 1 g): 18 parts of astragalus, 12 parts of ginseng, 15 parts of fructus viticis, 13 parts of ligusticum wallichii, 15 parts of rhizoma cimicifugae, 11 parts of cortex phellodendri, 10 parts of spina date seed, 11 parts of prepared rehmannia root, 12 parts of cistanche, 20 parts of rhizoma drynariae, 16 parts of epimedium herb, 15 parts of angelica sinensis, 13 parts of caulis spatholobi, 15 parts of radish seed, 17 parts of pangolin, 15 parts of magnetite and 10 parts of liquorice.
Example 6
A medicament (decoction) for treating cervicogenic tinnitus, which is prepared from the Chinese medicinal composition of embodiment 1 by a preparation method comprising the following steps of: preparing the medicinal materials according to the composition of the raw materials in the embodiment 1, adding water for decocting for two times, wherein the first time of decocting is 2 hours, the second time of decocting is 1.5 hours, the water adding amount is 3-5 cm of the medicine surface, and combining the two decoctions after the decoction is finished to obtain the decoction for treating the cervicogenic tinnitus.
The medication method comprises the following steps: the decoction is divided into 2 parts, and administered 1 time each day in the morning and evening, and uncooked, spicy, greasy and pungent food is prohibited during the treatment period.
The traditional Chinese medicine composition has the clinical effect of treating the cervicogenic tinnitus.
1. Object and general situation
100 cervical tinnitus patients, 42 male patients, 58 female patients, 18 years old the youngest, 72 years old the longest, half-year to 20 years old, 3.7 years old on average, and tinnitus of above grade 3 in Hospital, ming district, fushan City; the groups were randomized into 2 groups, 53 in the experimental group and 47 in the control group.
2. Diagnostic criteria
According to loudness classification, tinnitus has a major clinical manifestation that can be classified into the following seven levels:
level 0: no tinnitus;
stage 1: tinnitus has slight, if any, loudness;
and 2, stage: tinnitus is mild in loudness, but certainly audible;
and 3, level: medium loudness;
4, level: tinnitus is louder;
and 5, stage: tinnitus is loud and has a noisy feeling;
and 6, level: tinnitus is extremely loud, corresponding to the loudest noise experienced by the patient, such as the noise at takeoff of an aircraft.
3. The therapeutic criteria are as follows:
the effect is shown: after the invention is taken, the tinnitus disappears, and the tinnitus disappears or is obviously lightened, and reaches the level 0 or 1;
improvement: after the invention is taken, the tinnitus is improved to reach level 1; the weight is reduced to a certain degree, and the grade 2 is achieved;
and (4) invalidation: tinnitus still exists after the medicine is taken, and the tinnitus is the same as that before the treatment.
4. Method of administration
Dividing the patients of the experimental group into experimental group 1, experimental group 2, experimental group 3, experimental group 4 and experimental group 5, wherein the patients of the experimental group 1, the experimental group 2, the experimental group 3, the experimental group 4 and the experimental group 5 respectively take the decoction prepared from the traditional Chinese medicine composition of the embodiment 1-5 (the preparation method is the same as the embodiment 6), and respectively take the decoction for 1 time in the morning and at night, and avoid eating uncooked, spicy, greasy and pungent food during the treatment period;
dividing patients in control group into control group 1 and control group 2, taking LONGLONGCILI pill in control group 1, and taking LIUWEIDIHUANG pill in control group 2 according to instruction.
5. Judgment of therapeutic effects and clinical observation data
Ten days is a course of treatment, and after a medium-and-light tinnitus patient takes the decoction prepared from the traditional Chinese medicine composition for one course of treatment, symptoms can be obviously relieved, or tinnitus phenomenon disappears, and a severe tinnitus patient or a deaf patient can take the decoction for three to six courses of treatment, so that the symptoms can be effectively improved or completely cured without relapse.
Specifically, table 1 shows the clinical observation data, wherein the control group 47
Effective rate = (number of cured people + number of effective people + number of improved people)/total number of people × 100%.
TABLE 1 clinical observations
Group of Cure of disease Show effect Improvement of life Invalidation Total effective rate
Experimental group 1 3 5 2 1 90.9％
Experimental group 2 2 4 1 1 87.5％
Experimental group 3 4 4 2 2 83.3％
Experimental group 4 3 4 3 1 90.9％
Experimental group 5 3 5 3 0 100％
Total number of people 15 22 11 5 90.6％
Control group 1 2 7 10 5 79.2％
Control group 2 4 3 10 6 73.9％
Total number of people 6 9 21 11 76.6％
Specifically, according to the clinical observation data, compared with the existing conventional Chinese patent medicines for treating tinnitus (deafness zuoci pills and liuwei dihuang pills), the traditional Chinese medicine composition of the technical scheme can effectively treat the cervicogenic tinnitus, the effective rate reaches 90.6%, a moderate-and-mild tinnitus patient can take the traditional Chinese medicine composition for one course of treatment, the symptom can be obviously relieved or completely cured without relapse, and a severe tinnitus patient or a deafness patient can take the traditional Chinese medicine composition for three to six courses of treatment, so that the tinnitus symptom can be effectively improved.
The effects of the present invention will be further illustrated below in connection with three typical cases.
Typical case 1
Madam, male, born in 1977. Tinnitus symptoms appear in 7 months in 2020 of patients, the symptoms occur at a time, sound is like cicada tinnitus, tinnitus becomes worse when the sleep is insufficient in the last night, the sleep is affected during the night, the tinnitus is aggravated in the last half month, and the sound is loud and endless, even is worried. The cervical spondylosis is diagnosed in local hospitals when the cervical vertebra disease is caused by long-term desk-bending work and neck pain accompanied with slight activity limitation. In 2021, 2 months after the patients arrive at the civilian hospital in the Gaoming district in Fushan City, the cervical tinnitus is considered, and the syndrome is distinguished as 'deficiency of liver and kidney and obstruction of collaterals by blood stasis', the decoction prepared by decocting the traditional Chinese medicine composition is taken, the effect is achieved after 15 days, the tinnitus frequency is obviously reduced after 1 month, the patients continue to take the medicine for 1 month, and the tinnitus is radically cured, and the recurrence is not existed until now.
Typical case 2
Chen-chi is born in 1988, patients have sudden dizziness in 2016 months, accompanied by tinnitus, nausea and other symptoms, and are diagnosed as Meniere's syndrome in hospitals, after symptomatic treatment, the dizziness symptoms disappear, the tinnitus is often irregularly attacked, and the neck and shoulder tenderness begins to appear after half a year, the cervical vertebra physiological curvature is straightened, the tinnitus symptoms are aggravated, and the continuous tinnitus appears, even influences the hearing. The medicine provided by the invention can be used for treating cervical tinnitus in the hospital of Gaoming district in Fushan City before 3 months in 2020, and the diagnosis is 'deficiency of liver and kidney and obstruction of collaterals by blood stasis', the effect can be achieved after 10 days by adopting the medicine provided by the invention, the tinnitus can be obviously reduced and the degree is reduced after 20 days, and the tinnitus which is troubled for years can be radically treated after the medicine is continuously taken for 1 month.
Typical case 3
In a certain area, women are born in 1968, start tinnitus when the person is 30 years old, often have single or mixed sounds such as cicada buzzing, fizzing and nourishing sounds at the ears, and have symptoms such as soreness and weakness of waist and knees, fatigue and weakness, dizziness and blurred vision in serious cases, neck pain and limited head turning, and seriously affect normal life, and the effects are not achieved when the women are treated by adopting health care equipment such as a massage instrument, a rehabilitation instrument and the like. The patients have hospitalized at many places and the ears are systematically checked, and no abnormality is found. In the initial diagnosis in 2019, neck-derived tinnitus is considered, the traditional Chinese medicine composition is used for treating, the symptoms are distinguished as liver and kidney deficiency and blood stasis blocking collaterals, tinnitus is relieved after 20 days after the traditional Chinese medicine composition is taken, and tinnitus phenomenon and accompanying symptoms such as soreness and weakness of waist and knees, fatigue and weakness, dizziness and the like are obviously relieved after 1 month.
The technical principle of the present invention is described above in connection with specific embodiments. The description is made for the purpose of illustrating the principles of the invention and should not be construed in any way as limiting the scope of the invention. Based on the explanations herein, those skilled in the art will be able to conceive of other embodiments of the present invention without inventive step, and these embodiments will fall within the scope of the present invention.

Claims (10)

1. A traditional Chinese medicine composition for treating cervicogenic tinnitus is characterized by comprising the following raw materials: radix astragali, radix Ginseng, fructus Vitics Simplicifoliae, rhizoma Chuanxiong, rhizoma cimicifugae, cortex Phellodendri, semen Ziziphi Spinosae, radix rehmanniae Preparata, herba cistanches, rhizoma Drynariae, herba Epimedii, radix Angelicae sinensis, caulis Spatholobi, semen Raphani, squama Manis, magnetitum, and radix Glycyrrhizae.
2. The traditional Chinese medicine composition for treating the cervicogenic tinnitus as claimed in claim 1, which is characterized in that the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 15 to 20 portions of astragalus root, 10 to 15 portions of ginseng, 10 to 15 portions of chastetree fruit, 10 to 15 portions of Szechuan lovage rhizome, 10 to 15 portions of largetrifoliolious bugbane rhizome, 10 to 15 portions of amur corktree bark, 10 to 15 portions of spina date seed, 10 to 15 portions of prepared rehmannia root, 10 to 15 portions of desertliving cistanche, 15 to 20 portions of fortune's drynaria rhizome, 15 to 20 portions of epimedium herb, 15 to 20 portions of Chinese angelica, 10 to 15 portions of suberect spatholobus stem, 15 to 20 portions of radish seed, 15 to 20 portions of pangolin scales, 15 to 20 portions of magnetite and 10 to 15 portions of liquoric root.
3. The traditional Chinese medicine composition for treating cervicogenic tinnitus according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 10 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 20 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
4. The traditional Chinese medicine composition for treating the cervicogenic tinnitus as claimed in claim 2, which is characterized in that the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 15 parts of astragalus, 10 parts of ginseng, 10 parts of fructus viticis, 15 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 10 parts of spina date seed, 10 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of epimedium herb, 20 parts of angelica, 10 parts of caulis spatholobi, 15 parts of radish seed, 20 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
5. The traditional Chinese medicine composition for treating the cervicogenic tinnitus as claimed in claim 2, which is characterized in that the traditional Chinese medicine composition for treating the cervicogenic tinnitus comprises the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 15 parts of ginseng, 10 parts of fructus viticis, 10 parts of ligusticum wallichii, 10 parts of rhizoma cimicifugae, 10 parts of cortex phellodendri, 15 parts of spina date seed, 15 parts of prepared rehmannia root, 10 parts of cistanche, 15 parts of rhizoma drynariae, 20 parts of herba epimedii, 20 parts of angelica sinensis, 10 parts of caulis spatholobi, 20 parts of semen raphani, 15 parts of pangolin, 20 parts of magnetite and 10 parts of liquorice.
6. A method for preparing a medicament for treating cervicogenic tinnitus, which comprises using the Chinese medicinal composition for treating cervicogenic tinnitus according to any one of claims 2-5, and comprises the following steps: weighing the raw materials according to the mass parts, uniformly mixing the raw materials, grinding or decocting the mixture with water, and preparing the mixture into an oral preparation to obtain the medicine for treating the cervicogenic tinnitus.
7. The preparation method of the medicine for treating the cervicogenic tinnitus as claimed in claim 6, wherein the raw materials are weighed according to parts by weight, the raw materials are uniformly mixed and decocted with water to obtain decoction, the decoction is concentrated into paste, and auxiliary materials are added to prepare the oral preparation.
8. A medicament for the treatment of cervicogenic tinnitus prepared using the method of claim 6 for the preparation of a medicament for the treatment of cervicogenic tinnitus.
9. The medicament for treating the cervicogenic tinnitus according to claim 8, wherein the medicament for treating the cervicogenic tinnitus is an oral formulation.
10. The medicine for treating the cervicogenic tinnitus according to claim 8, wherein the oral preparation is any one of decoction, pills, powder, granules, oral liquid, capsules and tablets.
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CN104606514A (en) * 2015-02-11 2015-05-13 刘连强 Traditional Chinese medicine composition for treating kidney deficiency type tinnitus
CN106214885A (en) * 2016-08-15 2016-12-14 李伟 A kind of Chinese medicine treating tinnitus
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