CN104257809B - A kind of preparation method who treats constipation Tibetan medicine - Google Patents
A kind of preparation method who treats constipation Tibetan medicine Download PDFInfo
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Abstract
The invention discloses a kind of preparation method who treats constipation Tibetan medicine, be to adopt according to a certain weight ratio co-grinding method or water extraction and alcohol precipitation method or ethanol extract from water precipitation to make active component and be prepared from by ZANGQIANCAO, HALITUM PURPUREUM, alkali flower, sausage fruit, whin, leaf of Littelleaf Paraquilegia, Semen sesami nigrum, flax, castor bean, can be prepared into any conventional formulation for oral administration. This Tibetan medicine has effect of the knot that purges heat clearly, the broken stagnant ruffian that disappears. The disease such as weaken for the long-pending knot of stomach and intestine lump in the abdomen, constipation, belch stomachache, gastrointestinal function.
Description
Technical field
The present invention relates to a kind of preparation method who treats constipation Tibetan medicine, belong to Tibetan medicine field.
Background technology
Constipation is one group of different substantiality disease, main manifestations for drain knot just, defecation effort and defecation frequency reduce. Constipation isThe common disease being caused by Different types of etiopathogenises, as enterogastric diseases, the gastral systemic disease of accumulative total, many medicines also can causeConstipation.
Habitual constipation refers to long-term, chronic functional constipation, is mainly in the elderly. It is clinical common chronic digestibleRoad symptom, main manifestations is that defecation frequency minimizing, difficult defecation or ight soil are really up to the mark. Be common in primary Intestinal motility abnormal,Stool wriggles to carry and delays or Hirschsprung's disease etc. Result from that anxiety, pressure are large, enterogastric peristalsis imbalance more, or have awareness of defecation to bear just, shapeBecome vicious circle, cause habitual constipation.
Though itself is not a kind of disease, be found in various diseases, along with the change of dietary structure, spirit psychology andThe impact of social factor, the incidence of disease of constipation rises gradually, has a strong impact on people's quality of life, and at colon cancer, liver property brainIn the generation of the diseases such as disease, mammary gland disease, alzheimer's disease, play an important role, in the time of the disease such as acute myocardial infarction, cerebrovas-cularaccidentConstipation can cause life unexpected. Therefore early prevention and rational therapy constipation, the serious consequence that alleviate constipation brings greatlyAnd burden on society.
Although this disease is very harmful, not yet there is at present better solution, Western medicine, Chinese medicine, collaborative treatment of Chinese and western medicinesThe medicine of constipation is also a lot, and has obtained certain curative effect, but still has some patients to conventional emplastic unsatisfactory curative effect, or because ofIts side effect and can not applying; And Tibetan medicine treatment constipation has the advantages such as successful, side effect are little.
There is tight demand in the Tibetan medicinal preparation that therefore, people better treat constipation to curative effect. Up to now also do not find,Any report about Tibetan medicinal composition of the present invention and preparation method thereof. The inventor is through research repeatedly, and by animal andThe checking repeatedly of clinical testing, has finally found and has had Tibetan medicine oral drugs of the treatment of better curative effect constipation and preparation method thereof,Thereby complete the present invention.
Summary of the invention
The object of the invention is just to provide a kind of preparation method who more effectively treats constipation Tibetan medicine.
Tibetan medicine of the present invention is to be made or be made up of active component and pharmaceutically acceptable auxiliary material by active component, itsDescribed in active component be to be made by following bulk drugs: ZANGQIANCAO, HALITUM PURPUREUM, alkali flower, sausage fruit, whin, leaf of Littelleaf Paraquilegia, blackSesame, flax, castor bean.
It has selected ZANGQIANCAO, HALITUM PURPUREUM, alkali flower, sausage fruit, whin, leaf of Littelleaf Paraquilegia, Semen sesami nigrum, flax, castor bean to enterRow combination is as bulk drug, wherein (1) ZANGQIANCAO be madder wort light stem madder RubiawallichianaDecne. andTibet madder R.tibeticaHook.f. and belong to the dry root and rhizomes of several plants together. There is effect of clearing heat and cooling blood. WithIn blood disease, diffusion is got mildewed in warm conditions, lung kidney heat evil, intestine and small intestine heat. (2) HALITUM PURPUREUM is halide class halite family halite, main sodium chloride-containing(NaCl). There is warm stomach defaecation, effect of dissipate-swelling. For the complication of " Baconic " and " dragon ", abdominal distension borborygmus, constipation, the cancer of the esophagus is anti-Stomach. (3) alkali flower is Sulfates nahcolite scale family mineral trona, main containing sodium carbonate (Na2CO3). There is detoxify and drain pus, disappearFood reduces phlegm, the effect of expelling parasite defaecation. For Baconic's gasteremphraxis, indigestion, sore, parasitosis, toxic hepatitis, defecates unfavorable. (4) curedIntestines fruit is the dry mature fruit of legume purging cassia CassiafistulaL.. There is removing heat from the liver, removing toxic substances, detumescence, attacksUnder effect. for hepatitis, hepatotoxicity, constipation, limb edema. (5) whin is legume falcate crazyweed herb OxytropisThe dry herb of falcataBunge and whorlleaf oxytropis herb O.chiliophyllaRoyle. Have clearing heat and detoxicating, the myogenic sore that heals,Effect of weak thready hemostasis, defaecation. Be used for the treatment of plague, nosotoxicosis, grasserie, constipation, anthrax. (6) leaf of Littelleaf Paraquilegia is RanunculaceaePlant is intended the dry aerial parts of garden columbine Paraquilegiamicrophylla (Royle) Drumm.etHutch.. ToolThere is the stasis of blood, hemostasis, analgesia, the effect of hastening parturition. For traumatic injury, retention of afterbirth, lower stillborn foetus. (7) Semen sesami nigrum is that Pedaliaceae is plantedThe dry mature seed of thing sesame SesamumindicumL.. There is filling liver kidney, benefiting essence-blood, effect that ease constipation is dry. Be used forDizzy, Hiccough and deaf, poliosis, post disease alopecia, the dry constipation of intestines. (8) flax is flax family (Linaceae) plant flax LinumUsitatissimumL. dry mature seed. Have and moisturize, the effect of dispeling the wind. For the dry constipation of intestines, dry skin itch,Hair is withered to come off. (9) castor bean is the seed of euphorbia plant castor-oil plant RicinuscommunisL.. Have and relax bowel,Emetic, rush down the fiery effect of poison. For indigestion, nosotoxicosis, imperial, red bar, the Baconic syndrome causing of lacking of proper care. By these raw materialsMedicine is used in combination and makes each bulk drug effect produce synergy, thereby can effectively treat constipation.
The consumption of Tibetan medicine active component of the present invention is also groped in a large number to sum up through inventor and is drawn, each bulk drugConsumption for all having good therapeutic effect within the scope of following concrete weight proportion:
ZANGQIANCAO 20～60g, HALITUM PURPUREUM 15～45g, alkali are spent 15～45g, sausage fruit 25～75g, whin 15～45g, vacationGarden columbine 12.5～37.5g, Semen sesami nigrum 10～30g, flax 7.5～22.5g, castor bean 5～15g.
Be preferably: ZANGQIANCAO 32～48g, HALITUM PURPUREUM 24～36g, alkali spend 24～36g, sausage fruit, 40～60g, whin 24～36g, leaf of Littelleaf Paraquilegia 20～30g, Semen sesami nigrum 16～24g, flax 12～18g, castor bean 8～12g.
More preferably: ZANGQIANCAO 40g, HALITUM PURPUREUM 30g, alkali flower 30g, sausage fruit 50g, whin 30g, leaf of Littelleaf Paraquilegia25g, Semen sesami nigrum 20g, flax 15g, castor bean 10g.
The preparation of Tibetan medicine active component of the present invention can be that the bulk drug convection drying of above-mentioned consumption is pulverized and made; Also canWith the conventional method that the bulk drug of above-mentioned consumption adopted to Chinese medicine preparation if water extraction and alcohol precipitation method or ethanol extract from water precipitation are (referring to Cao ChunlinChief editor's " pharmaceutics of Chinese drugs " 73rd～74 pages, Science and Technology of Shanghai publishing house publishes in November, 1986) make.
The active component of Tibetan medicine of the present invention can add various conventional auxiliary material required while preparing different dosage form, as disintegrationAgent, lubricant, adhesive etc. are with conventional method of Chinese medicinal (" pharmaceutics of Chinese drugs " edited referring to Cao Chunlin, Science and Technology of ShanghaiPublishing house publishes in November, 1986) be prepared into any conventional peroral dosage form, as powder, pill, capsule, granule, sheetAgent etc.
Tibetan medicine of the present invention has effect of the knot that purges heat clearly, the broken stagnant ruffian that disappears. For the long-pending knot of stomach and intestine lump in the abdomen, constipation, belchStomachache, gastrointestinal function such as weaken at the disease.
The usage and dosage of Tibetan medicine of the present invention is: oral; A 1～1.5g, 1～3 time on the one.
[detailed description of the invention]
Carry out by the following examples further to set forth the preparation method of Tibetan medicine of the present invention.
The preparation of [embodiment 1] Tibetan medicine powder of the present invention:
Take ZANGQIANCAO 40g, HALITUM PURPUREUM 30g, alkali flower 30g, sausage fruit 50g, whin 30g, leaf of Littelleaf Paraquilegia 25g, Semen sesami nigrum20g, flax 15g, castor bean 10g, be ground into fine powder jointly after mixing, mix, and packing, obtains powder.
The preparation of [embodiment 2] Tibetan medicine pill of the present invention:
Take ZANGQIANCAO 20g, HALITUM PURPUREUM 15g, alkali flower 15g, sausage fruit 25g, whin 15g, leaf of Littelleaf Paraquilegia 12.5g, black sesameFiber crops 10g, flax 7.5g, castor bean 5g, be ground into fine powder jointly after mixing, mix, and with water pill, 60 DEG C of following being dried, beatsLight, packaging, obtains pill.
The preparation of [embodiment 3] Tibetan medicine granule of the present invention:
Take ZANGQIANCAO 60g, HALITUM PURPUREUM 45g, alkali flower 45g, sausage fruit 75g, whin 45g, leaf of Littelleaf Paraquilegia 37.5g, black sesameFiber crops 30g, flax 22.5g, castor bean 15g, be ground into fine powder jointly after mixing, mix, and adds auxiliary material granulation, 60 DEG C withLower dry, whole grain, packing, obtains granule.
The preparation of [embodiment 4] Tibetan medicine capsule of the present invention:
Take ZANGQIANCAO 32g, HALITUM PURPUREUM 24g, alkali flower 24g, sausage fruit 40g, whin 24g, leaf of Littelleaf Paraquilegia 20g, Semen sesami nigrum16g, flax 12g, castor bean 8g, be ground into fine powder jointly after mixing, mix, and packs gelatine capsule into, obtains capsule.
The preparation of [embodiment 5] Tibetan medicine tablet of the present invention:
Take ZANGQIANCAO 48g, HALITUM PURPUREUM 36g, alkali flower 36g, sausage fruit 60g, whin 36g, leaf of Littelleaf Paraquilegia 30g, Semen sesami nigrum24g, flax 18g, castor bean 12g, be ground into fine powder jointly after mixing, mix, and adds auxiliary material granulation, following dry at 60 DEG CDry, whole grain, compressing tablet, obtains tablet.
The beneficial effect of further setting forth below Tibetan medicine of the present invention by test example, these test examples have comprised the present inventionThe pharmacodynamics test of Tibetan medicine embodiment 1 powder and clinical observation on the therapeutic effect test.
The defecation of [test example 1] Tibetan medicine embodiment 1 powder of the present invention, little intestine movement, large intestine movement, intestines volumeThe tests such as impact, functions of loosening bowel relieving constipation:
Test material: anthology invention Tibetan medicine embodiment 1 powder is trial drug; DAHUANG TONGBIAN JIAONANG is washed river system by ChengduPharmaceutical factory produces, batch number 20110712; India ink is produced by Xi Zhong chemical plant, Beijing, batch number 20110808; MultipleSide's diphenoxylate is produced by Jiaozuo City Kang Li medicine company limited company, batch number 20111002; Yellow Jackets, SERVAImport packing, chemical plant product is known in upper sea-run, batch number 20110314; Kunming mouse, Wistar rat, real by LanzhouTesting animal center provides.
Experimental technique: 1, the defecation test of Tibetan medicine embodiment 1 powder of the present invention to constipation dehydration Constipation Model mouse: get bodyWeigh 24～26g healthy mice, male and female half and half, are divided into 6 groups at random by body weight, establish blank group, model control group, positive controlBasic, normal, high dose of group (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and Tibetan medicine embodiment 1 powder of the present invention (1.5g/kg, 3g/kg, 6g/kg)Amount group. Except blank group, other are respectively organized mouse and prohibit water non-fasting 72h, cause constipation dehydration Constipation Model. Blank groupThe 2% india ink suspension that gavage gives to be configured to distilled water, administration group gavage gives to replace 2% of distilled water with liquidIndia ink suspension, administration volume 1mL/20g body weight, after administration puts into mouse mouse box, 1, every box, underlay whiteClean filter paper, every mouse of observed and recorded is discharged the melaena sum that in time (min) of melaena and 4h, mouse is discharged first. tThe conspicuousness of checking each group difference, the results are shown in Table 1.
The impact (x ± s, n=10) of table 1 Tibetan medicine embodiment 1 powder of the present invention on constipation dehydration Constipation Model mouse defecation
Group number of animals dosage (g/kg) is arranged first row's melaena in melaena time (min) 4h and is counted
Blank group 10 194.6 ± 67.52.4 ± 1.6
Model control group 10 358.8 ± 15.4#0.3±1.8#
Positive controls 100.5325.4 ± 61.40.7 ± 1.6
Low dose group 101.5337.8 ± 63.80.5 ± 1.7
Middle dosage group 103269.2 ± 79.3*1.8±2.6*
High dose group 106231.1 ± 68.2**2.9±2.4**
Illustrate: with the comparison of blank group:#P < 0.01; With model control group comparison:*P<0.05；**P<0.0l。
2, the defecation test of Tibetan medicine embodiment 1 powder of the present invention to compound diphenoxylate (DC) model mice: animal and pointGroup, with 1, is respectively organized mouse and is prohibited water non-fasting 12h, and except blank group is to equivalent distilled water, all the other are respectively organized gavage and give compound groundFragrant promise ester (DC) suspension 50mg/kg. After 30min, each treated animal gavage gives tested medicine, administration volume 1mL/20g body weight,Blank group and model control group are to equivalent distilled water. The argol that every group of mouse of observed and recorded discharged is counted, loose stool is counted andThe not number of animals of defecation, Continuous Observation 12h, respectively organizes index, and t checks the conspicuousness of each group difference, the results are shown in Table 2.
The impact (x ± s, n=10) of table 2 Tibetan medicine embodiment 1 powder of the present invention on DC Constipation Model mouse defecation
Group number of animals dosage (g/kg) the argol loose stool not defecation number of animals of counting of counting
Blank group 10 8.4 ± 4.2800
Model control group 10 2.6 ± 2.52#00
Positive controls 100.53.9 ± 1.2800
Low dose group 101.54.1 ± 3.630.3 ± 0.270
Middle dosage group 1034.7 ± 2.58*0.5±0.230
High dose group 1069.4 ± 3.34**1.9±1.45**0
Illustrate: with the comparison of blank group:#P < 0.01; With model control group comparison:*P<0.05；**P<0.0l。
3, the defecation test of Tibetan medicine embodiment 1 powder of the present invention to normal mouse: get body weight 24～26g healthy mice, femaleHero half and half, is divided into 5 groups at random by body weight, establishes blank group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg) and the present inventionThe basic, normal, high dosage group of Tibetan medicine embodiment 1 powder (1.5g/kg, 3g/kg, 6g/kg). Blank group gavage distilled waterThe 2% india ink suspension being configured to, administration group gavage gives to replace 2% india ink that distilled water is configured to mix with liquidSuspension, administration volume is 1mL/20g body weight. After administration, mouse is put into mouse box, 1, every box, the clean filter paper of underlay white,Every mouse of observed and recorded is discharged the time (min) of melaena and the sum of the interior mouse discharge of 4h melaena first. It is poor that t checks between each groupDifferent conspicuousness, the results are shown in Table 3.
The impact (x ± s, n=10) of table 3 Tibetan medicine embodiment 1 powder of the present invention on normal mouse defecation
Group number of animals dosage (g/kg) is arranged first row's melaena in melaena time (min) 4h and is counted
Blank group 10 151.3 ± 73.42.6 ± 2.46
Positive controls 100.5119.7 ± 43.67.2 ± 2.26**
Low dose group 101.5143.6 ± 54.84.5 ± 1.43
Middle dosage group 103116.4 ± 47.55.6 ± 2.38*
High dose group 10698.6 ± 42.3*8.7±2.87**
Illustrate: with model control group comparison:*P<0.05；**P<0.0l。
4, Tibetan medicine embodiment 1 powder of the present invention is tested mouse small intestine ahead running: animal and grouping be with 3, taking carbon ink asMark, the 7% carbon ink suspension that blank group gavage gives to be configured to physiological saline, administration group gavage is usedThe 7% carbon ink suspension that liquid replaces distilled water to be configured to, administration volume is 0.4mL/20g body weight, 30min after gavage, cervical vertebra is de-Mortar is put to death mouse, and the taking-up stomach and intestine of cutting open the belly immediately, are laid on glass plate, measures displacement in intestinal tube of carbon ink head end and littleIntestines total length (from pylorus to ileum), calculates ink propulsive rate, distance/small intestine total length of carbon ink propelling rate=carbon ink front end and pylorus× 100%. T checks the conspicuousness of each group difference, the results are shown in Table 4.
The impact (x ± s, n=10) that table 4 Tibetan medicine embodiment 1 powder of the present invention advances small intestine movement of mice
Group number of animals dosage (g/kg) small intestine length (cm) carbon ink advance distance (cm) ink propulsive rate (%)
Blank group 10 53.8 ± 2.3442.5 ± 3.3278.17 ± 6.38
Positive controls 100.549.9 ± 4.1844.6 ± 6.4691.42 ± 12.08**
Low dose group 101.548.8 ± 5.1737.8 ± 6.2779.16 ± 9.64
Middle dosage group 10349.6 ± 3.1543.2 ± 6.7888.73 ± 9.53*
High dose group 10649.1 ± 4.1647.9 ± 5.38**96.65±6.72**
Illustrate: with model control group comparison:*P<0.05；**P<0.0l。
5, Tibetan medicine embodiment 1 powder of the present invention is tested the large intestine movement of rat: get body weight 250～350g healthy adultRat, all male, be divided at random 5 groups by body weight, establish blank group, positive controls (DAHUANG TONGBIAN JIAONANG 0.5g/Kg)With the basic, normal, high dosage group of Tibetan medicine embodiment 1 powder of the present invention (1.5g/kg, 3g/kg, 6g/kg). Anesthetized rat when experiment, soPostabdomen cropping, along median line otch, opens abdominal cavity and finds caecum and colon junction. Blank group rat in this portion to knotIn enteric cavity, inject the physiological saline containing 10% india ink, administration group is injected the liquid containing 10% india ink, administration volume2.5mL/kg body weight. 5min after administration, opens abdominal cavity immediately, separates and cut large intestine, takes out, and naturally straightens, and measures with meter rulerThe distance that large intestine length and prepared Chinese ink advance, calculates ink propulsive rate, carbon ink propelling rate=carbon ink advance distance/large intestine total length ×100%. T checks the conspicuousness of each group difference, the results are shown in Table 5.
The impact (x ± s, n=10) that table 5 Tibetan medicine embodiment 1 powder of the present invention advances normal rat large intestine
Group number of animals dosage (g/kg) large intestine length (cm) carbon ink advance distance (cm) ink propulsive rate (%)
Blank group 10 16.3 ± 1.46.2 ± 2.138.8 ± 15.2
Positive controls 100.515.8 ± 0.38.7 ± 3.354.8 ± 22.6**
Low dose group 101.516.9 ± 1.29.3 ± 3.1*59.3±24.7*
Middle dosage group 10316.4 ± 1.711.1 ± 5.2*62.4±23.8*
High dose group 10615.3 ± 1.710.8 ± 2.1**74.6±23.3**
Illustrate: with model control group comparison:*P<0.05；**P<0.0l。
6, Tibetan medicine embodiment 1 powder of the present invention affects test to mouse intestines volume: animal and grouping are with 3, and water is can't help in fastingAfter 12h, respectively organize according to dosage gastric infusion, blank group is to equivalent distilled water, administration volume 1mL/20g body weight. Administration 2.5hAfter disconnected animal cervical vertebra is put to death, cut off abdominal cavity, expose intestinal tube, in pylorus lower end and ileocecus ligation, from pylorus, place cuts intestinal tube,Carefully cut mesenterium with little scissors downwards along intestinal tube, cut off intestinal tube at ileocecus, on electronic balance, accurately weigh intestinal tube weightAmount. T checks the conspicuousness of each group difference, the results are shown in Table 6.
The impact (x ± s, n=10) of table 6 Tibetan medicine embodiment 1 powder of the present invention on mouse intestines volume
Group number of animals dosage (g/kg) intestinal tube weight (g)
Blank group 10 1.28 ± 0.26
Positive controls 100.51.54 ± 0.47
Low dose group 101.51.48 ± 0.15
Middle dosage group 1031.45 ± 0.27*
High dose group 1061.56 ± 0.23*
Illustrate: with model control group comparison:*P<0.05。
7, Tibetan medicine embodiment 1 powder of the present invention is tested mouse functions of loosening bowel relieving constipation: animal and grouping are with 3, and each group is by agentAmount gastric infusion, blank group is to equivalent distilled water, administration volume 1mL/20g body weight. After administration, mouse is put into mouse boxIn, 1, every box, the clean filter paper of underlay white, records in 4h and occurs soft stool, semiliquid stool, rare time and character just for the 1st time, with softJust represent purging and intestine lubricating action, represent defecating feces excretion with semiliquid stool, with rare discharge function that just represents. Soft stool refers to that excrement is shaped, but soft expandingMoisture content is more, and semiliquid stool is slightly shaped or is shapeless, scattered paste shape, rare just scattered paste shape or water liquid. T checks the remarkable of each group differenceProperty, the results are shown in Table 7.
The impact (x ± s, n=10) that table 7 Tibetan medicine embodiment 1 powder of the present invention relaxes bowel on mouse
Group number of animals dosage (g/kg) soft stool time (min) semiliquid stool time (min) rare just time (min)
Blank group 10 134.8 ± 10.3243.0243.0
Positive controls 100.553.5 ± 61.4187.3 ± 91.8243.0
Low dose group 101.552.7 ± 78.9185.2 ± 93.2243.0
Middle dosage group 10336.8 ± 24.6*128.4±95.7**205.8±61.4
High dose group 10627.9 ± 24.7*122.1±96.1**174.6±83.3
Illustrate: with model control group comparison:*P<0.05；**P<0.0l。
Result shows: the middle and high dosage of Tibetan medicine embodiment 1 powder of the present invention can make constipation dehydration Constipation Model mouse firstDischarge the time shorten of melaena, in mouse 4h, the total argol of discharge melaena color dot is counted and is increased, and the number of animals of defecation does not reduce, heightThe argol that dosage can make to discharge in DC Constipation Model mouse 12h is counted and is increased, and loose stool is counted and increased, and the number of animals of defecation does not subtractFew; With model control group comparison, its difference all has statistical significance. The middle dosage of Tibetan medicine embodiment 1 powder of the present invention just can makeIn normal mouse 4h, discharge melaena color dot sum and increase, high dose can make normal mouse discharge first the time shorten of melaena, mouseIn 4h, discharge melaena color dot sum and increase, with the comparison of blank group, its difference also has statistical significance, points out Tibetan medicine of the present inventionEmbodiment 1 all has and promotes more significantly animal excretion constipation dehydration Constipation Model mouse, DC Constipation Model mouse and normal mouseDischarge function. The middle and high dosage of Tibetan medicine embodiment 1 powder of the present invention can promote mouse small intestine prepared Chinese ink advance distance; The present inventionThe basic, normal, high dosage of Tibetan medicine embodiment 1 powder can promote rat large intestine prepared Chinese ink advance distance, and with the comparison of blank group, it is poorDifferent all have a statistical significance, points out Tibetan medicine embodiment 1 powder of the present invention to have the ahead running that promotes intact animal small intestine, large intestine,Strengthen the function of enterocinesia. The middle and high dosage of Tibetan medicine embodiment 1 powder of the present invention can obviously increase mouse small intestine moisture,Mouse intestinal tube weight is increased, and it is large that enteron aisle volume becomes, and makes mouse occur that soft stool, semiliquid stool time obviously shortens, with blank groupRelatively, its difference all has statistical significance, points out Tibetan medicine embodiment 1 powder of the present invention to have obvious minimizing enteron aisle to inhale moistureReceive, make the softening functions of loosening bowel relieving constipation of defecating. Above result shows, Tibetan medicine embodiment 1 powder of the present invention has stronger promotion movingThing defecation, increase enterocinesia and functions of loosening bowel relieving constipation, therefore, have certain value to constipation clinically.
The clinical observation on the therapeutic effect of [test example 2] 1, Tibetan medicine embodiment of the present invention 1 powder treatment constipation:
Physical data: constipation patient is totally 100 examples, is divided into two groups at random by digital method, treatment group 50 examples, and male 33 examples, female 17Example, 53.5 years old mean age; Control group 50 examples, male 35 examples, female's 15 examples, 53 years old mean age. Age of two groups of cases, sex andPhysical data difference not statistically significant.
Diagnostic criteria: according to " traditional Chinese medical science disease Standardization of diagnosis and curative effect ", defecation time extends, within two days, with the last time, ight soil is dryDry hard; Severe one difficulty in defecation, dry as chestnut, can accompany few abdominal distension anxious, refreshing tired weak, stomach is received the disease such as go down.
Exclusion standard: get rid of enteron aisle organic disease.
Methods for the treatment of: treatment group: adopt Tibetan medicine embodiment 1 powder of the present invention, oral; A 1.5g, 3 times on the one. ContrastGroup: DAHUANG TONGBIAN JIAONANG, 0.9g/ time, 1 day 1 time, warm water delivery service before sleeping evening. Two groups all to treat 15 days as 1 course for the treatment of, 1Finish to add up treatment results the course for the treatment of.
Clinical efficacy evaluation criteria: according to " traditional Chinese medical science disease Standardization of diagnosis and curative effect ", cure: 2 days with interior defecation 1 time, just matterTurn profit, unobstructed when solution, short-term is without recurrence; Take a turn for the better: within 3 days, with interior defecation, just matter turns profit, and it is smooth that defecation is owed; Do not heal: symptom is without improvement.Healing adding improvement and adding up to total effective rate.
Clinical observation result is in table 8.
Table 8 liang group curative effect comparison (example, %)
Group number of cases is cured the more total effective rate that takes a turn for the better not
Treatment group 503711296.00*
Control group 503114590.00
Note: with control group comparison*P<0.05。
Bad reaction: have no adverse reaction in two groups of therapeutic processes; Two groups of courses for the treatment of finish rear check hepatic and renal function all normal.
Clinical observation result shows: Tibetan medicine embodiment 1 powder treatment constipation determined curative effect of the present invention, clinic is promoted and madeWith, there is certain application prospect.
2, the clinical observation on the therapeutic effect of Tibetan medicine embodiment 1 powder treatment chronic constipation of the present invention:
Physical data: 80 routine patients, the Roman II diagnostic criteria and the Chinese Medical Association's constipation diagnosis and treatment that all meet constipation are provisionalChronic constipation diagnostic criteria in standard. Wherein male 33 examples, female's 47 examples, 33～71 years old age, average 50.5 years old, the course of disease 2.1～11Year, average course of disease 27.12 months.
Methods for the treatment of: adopt Tibetan medicine embodiment 1 powder of the present invention, oral; A 1.5g, 3 times on the one. It within 15 days, was 1 course for the treatment of.
Clinical efficacy evaluation criteria: evaluate according to Ministry of Public Health's Clinical Researches of New Drugs guideline. (1) effective: to take medicineIn latter 3 days, reach following index: 1. defecation frequency recovers normal; 2. ight soil proterties transfers to normally; 3. defecation is unobstructed and without difficulty,When defecation without sense of discomfort. (2) effective: in effective, in listed 3 indexs, to reach 1～2 person. (3) invalid: take medicine after 3 days, onState index and the front all no significant differences for the treatment of.
Treatment results: this organizes 80 routine patients, after finishing the course for the treatment of, effective 52 examples (65.00%); Effective 24 examples (30.00%); NothingImitate 4 examples (5.00%). Total effective rate 95.00%. Still effective 46 examples (88.46%) of effective 52 examples of call-on back by phone after 60 days; Effective 24Effective 17 examples (70.83%) still in example. Total effective rate 78.75% after 60 days.
Treatment results shows: Tibetan medicine embodiment 1 powder treatment constipation determined curative effect of the present invention, clinic is promoted the use of.
In the preparation of conventional oral solid formulation, the preparation of powder is in other conventional oral solid formulation preparation processPart operation above, the test example of powder has proved to have good effect aspect treatment constipation, has also just illustrated conventionalPill in oral solid formulation, granule, capsule, tablet also have same effect; Be the above-mentioned embodiment enumerating 1-5 have same effect. Illustrate that Tibetan medicine of the present invention has good effect aspect treatment constipation.
Claims (4)
1. treat a preparation method for constipation Tibetan medicine, it is characterized in that comprising the following steps: that this Tibetan medicine is by active component systemBecome or made by active component and pharmaceutically acceptable auxiliary material, wherein said active component is by following concrete weightThe bulk drug of proportioning is made: ZANGQIANCAO 20～60g, HALITUM PURPUREUM 15～45g, alkali are spent 15～45g, sausage fruit 25～75g, whin 15～45g, leaf of Littelleaf Paraquilegia 12.5～37.5g, Semen sesami nigrum 10～30g, flax 7.5～22.5g, castor bean 5～15g; Mix, adoptComminuting method or water extraction and alcohol precipitation method or ethanol extract from water precipitation are made active component.
2. the preparation method of Tibetan medicine according to claim 1, wherein takes the bulk drug of following concrete weight proportion: ZANGQIANCAO32～48g, HALITUM PURPUREUM 24～36g, alkali spend 24～36g, sausage fruit 40～60g, whin 24～36g, leaf of Littelleaf Paraquilegia 20～30g,Semen sesami nigrum 16～24g, flax 12～18g, castor bean 8～12g.
3. the preparation method of Tibetan medicine according to claim 2, wherein takes the bulk drug of following concrete weight: ZANGQIANCAO 40g,HALITUM PURPUREUM 30g, alkali flower 30g, sausage fruit 50g, whin 30g, leaf of Littelleaf Paraquilegia 25g, Semen sesami nigrum 20g, flax 15g, castor bean 10g.
4. according to the preparation method of any one Tibetan medicine described in claim 1-3, it also comprises the following steps: active groupDivide with pharmaceutically acceptable auxiliary material and make powder, pill, granule, capsule or tablet.
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