CN103948786A - Traditional Chinese medicine for treating diabetes - Google Patents
Traditional Chinese medicine for treating diabetes Download PDFInfo
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Abstract
The invention provides a medicine for treating diabetes. The medicine uses ginseng, Radix Ophiopogonis, Chinese yam, Rhizoma Anemarrhenae, Ligustri Lucidi Fructus, Yetbadetajo Hert, roasted Rhizoma Atractylodis Macrocephalae, Radix Astragali, Peach Seed, Radix Paeoniae Rubra, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, unprepared rehmannia root, Cortex Lycii and Trichosanthis Radix as raw materials, or uses ginseng, Ephedrine alkaloid, Cattail Pollen flavone, Radix Angelicae Pubescentis, beta-oleyl alcohol of Leaf of Tasmanian Bluegum, Angelica polymorpha Maxim, Radix Puerariae, Rhizoma Anemarrhenae, Ligustri Lucidi Fructus, Yetbadetajo Hert, roasted Rhizoma Atractylodis Macrocephalae, Peach Seed, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, Radix Scrophulariae, Cortex Lycii and Herba Leonuri as raw materials, or uses ginseng, epigallocatechin gallate, Myricaria laxiflora, Angelica polymorpha Maxim, Radix Ophiopogonis, Yetbadetajo Hert, white peony root, Peach Seed, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, Radix Scrophulariae, Cortex Lycii, Radix Scutellariae, Corsvenor Momordica Fruit and mulberry leaf as raw materials, or uses ginseng, tea polyphenol, konjak, Chaenomeles Speciosa(sweet) Nakai, Radix Ophiopogonis, Yetbadetajo Hert, Peach Seed, Chinese yam, Medicinal Cyathula Root, Cortex Moutan, Chinese magnoliavine, berberine, 3-6 parts of Radix Scrophulariae, mulberry leaf, Cortex Lycii, unprepared rehmannia root and Trichosanthis Radix as raw materials. The medicine has simple and unique formula and preparation method.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes, the Chinese patent medicine of specifically preparing taking Chinese herbal medicine as crude drug, the invention still further relates to the preparation method of this medicine.
Background technology
Diabetes are commonly encountered diseases, frequently-occurring disease, how by natural endowment deficiency, the plain body deficiency of YIN, multiple because of due to eating and drinking without temperance, feelings will are unsuccessful or labor wants excessively, metabolism disorder disease taking chronic hyperglycemia as feature, the traditional Chinese medical science claims diabetes, because of the deficiency of YIN scorching, the five internal organs weakness, cause the three-many-one-little classical symptom of polyphagia, polydipsia, polyuria and emaciated physique, its General Symptoms lumbago, extremities aching pain, the sense of brothers ant, numbness, skin pruritus, hyposexuality, severe patient can concurrent heart, kidney and retinopathy, and can produce ketoacidosis and cause stupor, death.
Theory of Chinese medical science is thought: the basic pathogenesis of diabetes is that the deficiency of YIN is scorching, and taking the deficiency of YIN as this, scorching is mark, scorching inclined to one side Sheng of YIN fluid deficiency, and both reciprocal causations again, more void is scorching more contains for the moon, scorchingly more contains that the moon is more empty.The main diseases position of quenching one's thirst is lung, spleen, stomach, kidney, and its middle kidney is the most key.Lung governing diffusion, is source waterborne, and cloudy impairing the lung is dry, and body fluid loses in compress, taste lose its moisten foster, kidney yin lose its moisten.Stomach is reservoir of food and drink, and The spleen has the function to transport and transform nutrients, is capable its body fluid of stomach, stomach-Yin side consumption, deficiency of spleen-YIN, rapid digestion of food and do not fill muscle, body fluid being unable to be produced and scorching interior vehement, the upper lung liquid that burns again, lower consumption kidney yin.The main water store essential substances of kidney, is the congenital foundation, and deficiency of the kidney yin is deficiency-fire produced in the interior, also can go up consumption lung spleen, therefore suffering from a deficiency of the kidney, stomach-heat due to lung-dryness often exists simultaneously, and impact each other, polydipsia, polyphagia, polyuria and become thin mutually normal and see, deficiency of both QI and YIN, negative and positive all decline.Interdependence between yin and yang is use mutually, the protracted inflammation of quenching one's thirst, and the disease of the common deficiency of both QI and YIN of deficient YIN affecting YANG,, there is the disease of deficiency in both YIN and YANG, asthenia of both the spleen and kidney in the passing of time deficiency of YIN affecting YANG.Positive QI-insufficiency, raw in blood stasis, yin asthenia generating intrinsic heat, damages cloudy consumption liquid, the blood vessels empty puckery blood stasis that forms, deficiency of both QI and YIN or deficiency of both YIN and YANG for it.The weary source of blood biochemical, moves unablely, and the also hemopoietic stasis of blood, makes again blood vessels obstructed, and internal organs lose supports, therefore quench one's thirst normal relevant with blood stasis, in treatment with YIN nourishing and the production of body fluid promoting, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling is basic principle.
Doctor trained in Western medicine is mainly to use metformin, glimepiride, gliclazide, rosiglitazone etc. to the treatment of diabetes, although these medicines have the reasonable hypoglycemic effect of falling, but toxic and side effects is obvious, take in process and want periodic monitoring blood glucose, life-time service can cause the infringement of hepatic and renal function and produce toleration, if dosage is excessive, can make blood glucose be reduced to below normal value, cause hypoglycemia, even can cause hypoglycemic shock, stupor, severe patient can lethally be died.
The Chinese-western medicine preparation diabetes pill of the treatment diabetes that use clinically at present, falls hypoglycemic Western medicine glimepiride although added to have, and has certain effect to alleviating the symptom of three-many-one-little, falls hypoglycemic DeGrain, and has certain side effect.
Summary of the invention
The object of the present invention is to provide a kind of pure Chinese medicine formula that utilizes treatment diabetes, can effectively reduce blood glucose, eliminate scorchingly because of the deficiency of YIN, the five internal organs weakness causes polyphagia, polydipsia, the generation of the three-many-one-little classical symptom of polyuria and emaciated physique.
The present invention realizes above-mentioned purpose like this: a kind of Chinese medicine formula for the treatment of diabetes, and belong to and reduce blood glucose type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 2-6 part, Radix Ophiopogonis 2-6 part, Rhizoma Dioscoreae 5-10 part, Rhizoma Anemarrhenae 5-10 part, Fructus Ligustri Lucidi 5-10 part, Herba Ecliptae 3-8 part, Rhizoma Atractylodis Macrocephalae (parched) 5-10 part, Radix Astragali 3-8 part, Semen Persicae 2-7 part, Radix Paeoniae Rubra 5-10 part, Cortex Moutan 5-11 part, Radix Cyathulae 3-8 part, Fructus Arctii 3-8 part, Radix Rehmanniae 5-11 part, Cortex Lycii 3-8 part, Radix Trichosanthis 3-8 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 4-6 part, Radix Ophiopogonis 4-6 part, Rhizoma Dioscoreae 8-10 part, Rhizoma Anemarrhenae 8-10 part, Fructus Ligustri Lucidi 8-10 part, Herba Ecliptae 5-8 part, Rhizoma Atractylodis Macrocephalae (parched) 8-10 part, Radix Astragali 6-8 part, Semen Persicae 4-7 part, Radix Paeoniae Rubra 8-10 part, Cortex Moutan 8-11 part, Radix Cyathulae 6-8 part, Fructus Arctii 5-8 part, Radix Rehmanniae 8-11 part, Cortex Lycii 6-8 part, Radix Trichosanthis 6-8 part.
Further preferred Chinese medicine ingredients and weight portion are: 5.7 parts of Radix Ginsengs, 5.7 parts of Radix Ophiopogonis, 9.5 parts of Rhizoma Dioscoreaes, 9.5 parts of the Rhizoma Anemarrhenaes, 9.5 parts of Fructus Ligustri Lucidi, 6 parts of Herba Ecliptaes, 9.5 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 6.8 parts of the Radixs Astragali, 5 parts, Semen Persicae, 9.5 parts of Radix Paeoniae Rubra, 9.5 parts of Cortex Moutans, 6.8 parts of Radix Cyathulaes, 6 parts of Fructus Arctiis, 9.5 parts, the Radix Rehmanniae, 6.8 parts of Cortex Lycii, 6 parts of Radix Trichosanthis.
The production method that above-mentioned each component is made to medicine of the present invention is to adopt one kettle way to make, that is, and and after all medicaments are mixed, add water to 1～2 times of medicine gross weight, soak 30min, at 110～120 DEG C, heat 20min, then reduce temperature to 100～105 DEG C, continue heating 20min, then temperature to 110～120 DEG C that raise, continue heating 10min, be again cooled to 80～90 DEG C, heating 10min, cooling, filter, remove slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into thick paste shape extractum, and dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, makes tablet or pill after sterilizing.
Or by above-mentioned gained extractum, dry and pulverize, after adding adjuvant and being mixed, granulate, after dry sterilization, pack granulation agent.
Its pharmacological action of the formula that foregoing invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Rhizoma Dioscoreae tonifying spleen-yin and consolidating semen is micro-, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Ecliptae nourishing YIN to lower pathogenic fire, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and regulating the stomach, Radix Astragali QI invigorating, with the effect of the ginseng of helping others, Semen Persicae, Radix Paeoniae Rubra, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Fructus Arctii, the Radix Rehmanniae, Cortex Lycii clearing away heat and cooling blood, fall asthenic fire, Radix Trichosanthis promoting the production of body fluid to quench thirst clearly.By the reasonable formula of ten a few herbs, reach nourshing Yin and drynsessmoistening prescription, YIN nourishing and the production of body fluid promoting, hypoglycemic effect is fallen, and obvious through clinical result of use.
The Chinese medicine that the formula of foregoing invention makes has the following advantages:
1. this formula is taking natural edible-plant medicine as raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 9 Zhou Houneng make blood glucose be reduced to normal level, within 67 weeks, can fully recover, and this medicine, without sweet taste, is cured tracing study in latter 6 months, is normally through hepatic and renal function inspection, human body is had no side effect, without toleration.
2. the prepared Chinese medicine for treating diabetes of the formula of foregoing invention is without bitterness sense, can long-term taking, and sick the lighter, dose reduces by half, and sick severe one can be according to aggravation dose, can not cause because dosage is excessive blood glucose to be reduced to below normal value, causes hypoglycemia.
3. the formula of foregoing invention can use with other antidiabetic drugs and insulin combination, but can greatly reduce the dosage of antidiabetic drug and insulin, and therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. the formula YIN nourishing and the production of body fluid promoting of foregoing invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can further be taken foot bath, takes and is used in conjunction with treatment diabetes with this.
For showing the therapeutic effect of medicine of the present invention to diabetes, the present invention selects patient's 150 examples that medical history, the state of an illness, age, sex and former Therapeutic Method are suitable to observe for system temporarily, is divided at random 2 groups.Treatment group 80 examples, male 48 examples, female's 32 examples; 44.5～76.8 years old age, average (60.65 ± 16.15) year; Diabetic duration 3～15.2 years, average (6.22 ± 2.51) year; Diabetic duration 0.55～6.5 year, average (3.85 ± 0.72) year.Matched group 70 examples, male 36 examples, female's 34 examples; 42.4～71.5 years old age, average (56.95 ± 14.55) year; Diabetic duration 2.5～14.2 years, average (4.88 ± 2.16) year; Diabetic duration 0.3～5.8 year, average (3.46 ± 1.15) year.The aspect comparisons such as 2 groups of patient ages, sex, the course of disease, the state of an illness, difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 3 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the application's matched group antidiabetic drug adopts diabetes pill.
Detection method is regularly to detect fasting glucose (FPG), 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situation after the meal.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 1 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 2 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
That the reduction of blood sugar content is had to diversity is remarkable for the Chinese medicine formula of foregoing invention as can be seen from Table 1, fasting glucose content is reduced to 4.9 ± 0.28 from 16.3 ± 0.95,2 hours after the meal, blood sugar content is reduced to 3.95 ± 1.85 from 21.85 ± 0.73, this difference tool is very significant (P < 0.01), but the formula of foregoing invention basic there was no significant difference (P >=0.05) compared with diabetes pill.Take formula of the present invention after 3 months, glucose in urine content significance reduces, and this content is reduced to normal urine sugar value, and described in patient, the phenomenon of polyphagia, polydipsia, polyuria has not had, and through the treatment of nearly 3 months, body weight reached normal level substantially.As can be seen from Table 2, take Chinese medicine formula of the present invention, before and after cholesterol and triglyceride, content obviously reduces, after the treatment of 3 months, substantially reach normal level, this difference tool is very significant (P < 0.01), and insulin content is being treated front and back, within 2 hours after the meal, is slightly being increased, but difference is little, also difference is little compared with diabetes pill for above-mentioned formula of the present invention, its no significant difference (P > 0.05).Through after 67 weeks take, diabetes are effected a radical cure substantially, and the cure rate of diabetics reaches 95% by statistics, after again through the tracing study of 6 months, hepatic and renal function is all normal, does not find toxic and side effects.
Another object of the present invention is to provide a kind of Chinese medicine formula for the treatment of diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 4-8 part, Herba Ephedrae alkaloid 2-7 part, Pollen Typhae ketone 2-5 part, Radix Angelicae Pubescentis 2-5 part, β-eucalyptus leaves oleyl alcohol 4-8 part, Radix Pternopetali vulgaris 3-9 part, Radix Puerariae 3-9 part, Rhizoma Anemarrhenae 4-8 part, Fructus Ligustri Lucidi 4-8 part, Herba Ecliptae 5-10 part, Rhizoma Atractylodis Macrocephalae (parched) 5-9 part, Semen Persicae 2-5 part, Cortex Moutan 5-9 part, Radix Cyathulae 3-6 part, Fructus Arctii 3-6 part, Radix Scrophulariae 4-8 part, Cortex Lycii 3-6 part, Herba Leonuri 2-7 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 6-8 part, Herba Ephedrae alkaloid 5-7 part, Pollen Typhae ketone 3.5-5 part, Radix Angelicae Pubescentis 2-3.5 part, β-eucalyptus leaves oleyl alcohol 6-8 part, Radix Pternopetali vulgaris 6.5-8 part, Radix Puerariae 5-7 part, Rhizoma Anemarrhenae 5-6.5 part, Fructus Ligustri Lucidi 5-7 part, Herba Ecliptae 5-7 part, Rhizoma Atractylodis Macrocephalae (parched) 6.5-7.8 part, Semen Persicae 2.5-4.2 part, Cortex Moutan 6.8-8.5 part, Radix Cyathulae 4-5.5 part, Fructus Arctii 4-6 part, Radix Scrophulariae 4-6 part, Cortex Lycii 3-5 part, Herba Leonuri 5-7 part.
Further preferred Chinese medicine ingredients and weight portion are: 6.5 parts of Radix Ginsengs, 5.5 parts of Herba Ephedrae alkaloids, 4 parts of Pollen Typhae ketone, 3 parts of Radix Angelicae Pubescentiss, 6.5 parts of β-eucalyptus leaves oleyl alcohol, 7 parts of Radix Pternopetali vulgariss, 5.8 parts of Radix Puerariaes, 6 parts of the Rhizoma Anemarrhenaes, 6 parts of Fructus Ligustri Lucidi, 6 parts of Herba Ecliptaes, 7 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 3.8 parts, Semen Persicae, 7.5 parts of Cortex Moutans, 4.5 parts of Radix Cyathulaes, 4.5 parts of Fructus Arctiis, 5.5 parts of Radix Scrophulariaes, 4.5 parts of Cortex Lycii, 5 parts of Herba Leonuris.
The production method that above-mentioned each component is made to medicine of the present invention is to adopt one kettle way to make,,, after all medicaments are mixed, add water to 1～2 times of medicine gross weight, soak 30min, at 110～120 DEG C, heat 20min, then reduce temperature to 100～105 DEG C, cooling, filter, remove slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into thick paste shape extractum, and dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, makes tablet or pill after sterilizing.
Or by above-mentioned gained extractum, dry and pulverize, after adding adjuvant and being mixed, granulate, after dry sterilization, pack granulation agent.
Its pharmacological action of the formula that the present invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Herba Ephedrae alkaloid can increase insulin sensitivity, reduce serum free fatty acid, improve Insulin Resistance, and then repair B cell, Pollen Typhae ketone hemostasis with astringents, promoting the circulation of blood blood stasis dispelling, blood sugar lowering, blood fat reducing.Radix Angelicae Pubescentis expelling wind and dampness, dispersing cold for relieving pain, controls lumbocrural pain, β-eucalyptus leaves oleyl alcohol can drying damp and strengthening spleen, expelling wind and cold, and then increase glycogen synthetase activity, Radix Pternopetali vulgaris cold expelling regulating QI to relieve pain, strengthening spleen, tonifying kidney, Radix Puerariae improves liver function, enhance metabolism, blood falls in toxin expelling, regulates blood-fat and blood sugar, promotes hemopoietic, suppress aldose reductase activity, affect islet beta cell function.Rhizoma Dioscoreae tonifying spleen-yin and consolidating semen is micro-, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Ecliptae nourishing YIN to lower pathogenic fire, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and regulating the stomach, Radix Astragali QI invigorating, with the effect of the ginseng of helping others, Semen Persicae, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Radix Scrophulariae consumption of YIN caused by febrile disease, crimson tongue excessive thirst, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, enter nutrient blood with controlling heat, Fructus Arctii, Cortex Lycii clearing away heat and cooling blood, fall asthenic fire clearly.By the reasonable formula of ten a few herbs, reach nourshing Yin and drynsessmoistening prescription, YIN nourishing and the production of body fluid promoting, hypoglycemic effect is fallen, and obvious through clinical result of use.
The Chinese medicine that the formula of foregoing invention makes has the following advantages:
1. this formula is taking natural edible-plant medicine as raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 8 Zhou Houneng make blood glucose be reduced to normal level, within 65 weeks, can fully recover, and this medicine, without sweet taste, is cured tracing study in latter 6 months, is normally through hepatic and renal function inspection, human body is had no side effect, without toleration.
2. the prepared Chinese medicine for treating diabetes of formula of the present invention is without bitterness sense, can long-term taking, and sick the lighter, dose reduces by half, and sick severe one can be according to aggravation dose, can not cause because dosage is excessive blood glucose to be reduced to below normal value, causes hypoglycemia.
3. formula of the present invention promotes insulin secretion type, can stimulate AMP activated protein kinase activity, increase insulin sensitivity, reduce serum free fatty acid (FFA) level, improve cell membrane Insulin receptor INSR density, improve insulin resistant, can combine with other antidiabetic drugs use (can not increase the medicine of insulin), but the dosage that can greatly reduce antidiabetic drug, therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. formula YIN nourishing and the production of body fluid promoting of the present invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can further be taken foot bath, takes and is used in conjunction with treatment diabetes with this.For showing the therapeutic effect of medicine of the present invention to diabetes, the present invention selects patient's 100 examples that medical history, the state of an illness, age, sex and former Therapeutic Method are suitable to observe for system temporarily, is divided at random 2 groups.Treatment group 67 examples, male 35 examples, female's 32 examples; 46～73 years old age, average (59.5 ± 13.5) year; Diabetic duration 5～16.2 years, average (10.6 ± 5.6) year; Diabetic duration 0.55～7 year, average (3.78 ± 3.22) year.Matched group 33 examples, male 19 examples, female's 14 examples; 39.5～74.5 years old age, average (57 ± 17.5) year; Diabetic duration 4.3～16.2 years, average (4.25 ± 5.95) year; Diabetic duration 0.6～8.1 year, average (4.35 ± 3.75) year.The aspect comparisons such as 2 groups of patient ages, sex, the course of disease, the state of an illness, difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 2 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the application's matched group antidiabetic drug adopts diabetes pill.
Detection method is regularly to detect fasting glucose (FPG), 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situation after the meal.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 3 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 4 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
The diversity that above-mentioned Chinese medicine formula reduces blood sugar content is as can be seen from Table 3 remarkable, this difference tool is very significant (P < 0.01), but, take after 3 months, fasting glucose content does not reach normal level substantially, eat latter two as a child, blood sugar content is near 11, explanation, take after above-mentioned Chinese medicine, resistance to sugar amount shows slightly reduction, and single after 67 weeks, blood sugar content is in normal level; Above-mentioned Chinese medicine formula is significant difference little (p >=0.05) compared with diabetes pill, takes Chinese medicine formula of the present invention after 3 months, and before and after cholesterol and triglyceride, content obviously reduces, and TG drops to 0.11 ± 0.15mmol/L from 3.7 ± 1.8mmol/L; TC drops to 4.28 ± 0.3mmol/L from 12.0 ± 2.8mmol/L, this difference tool is very significant (P < 0.01), as can be seen from Table 4, for insulin content, front and back significant difference, Fins is elevated to 45.9 ± 12.6pmol/L from 21.37 ± 5.9pmol/L, and 2hlns is elevated to 128.3 ± 13pmol/L from 35.8 ± 9.4pmol/L, reach normal level, its difference has significant (P < 0.01).Illustrate, this magistral medicines may have the effect of excreting insulin, and promote to have has the diabetes patient of hypercholesterolemia and triglyceride to reduce cholesterol level and fat content simultaneously simultaneously.Described in patient, the phenomenon of polyphagia, polydipsia, polyuria has not had, and body weight also reaches normal level gradually, and after 65 weeks, the cure rate of diabetics reaches 98%, and through the tracing study of 6 months, hepatic and renal function was normally, does not find toxic and side effects.
Another object of the present invention is to provide a kind of Chinese medicine formula for the treatment of diabetes, belong to the Chinese medicine formula that strengthens insulin sensitivity sexual type, Chinese medicine ingredients and weight portion are: Radix Ginseng 2-8 part, epi-nutgall base catechin and gallate 4-9 part, flower thinning Cacumen Myricariae Germanicae 3-6 part, Radix Pternopetali vulgaris 5-10 part, Radix Ophiopogonis 2-5 part, Herba Ecliptae 3-6 part, Radix Paeoniae Alba 3-6 part, Semen Persicae 5-9 part, Cortex Moutan 3-6 part, Radix Cyathulae 3-6 part, Fructus Arctii 3-6 part, Radix Scrophulariae 4-6 part, Cortex Lycii 3-6 part, Radix Scutellariae 4-8 part, Fructus Momordicae 3-6 part, Folium Mori 4-8 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 6-8 part, epi-nutgall base catechin and gallate 8-9 part, flower thinning Cacumen Myricariae Germanicae 4-6 part, Radix Pternopetali vulgaris 5-8 part, Radix Ophiopogonis 2-4 part, Herba Ecliptae 5-6 part, Radix Paeoniae Alba 5-6 part, Semen Persicae 7-9 part, Cortex Moutan 3-5 part, Radix Cyathulae 3-5 part, Fructus Arctii 4-6 part, Radix Scrophulariae 5-6 part, Cortex Lycii 3-5 part, Radix Scutellariae 5-7 part, Fructus Momordicae 3-5 part, Folium Mori 6-8 part.
Further preferred Chinese medicine ingredients and weight portion are: 7 parts of Radix Ginsengs, 9 parts of epi-nutgall base catechin and gallates, 6 parts of flower thinning Cacumen Myricariae Germanicaes, 6 parts of Radix Pternopetali vulgariss, 3 parts of Radix Ophiopogonis, 5 parts of Herba Ecliptaes, 5 parts of the Radix Paeoniae Albas, 8.5 parts, Semen Persicae, 4.8 parts of Cortex Moutans, 4.8 parts of Radix Cyathulaes, 4.8 parts of Fructus Arctiis, 5.5 parts of Radix Scrophulariaes, 4.5 parts of Cortex Lycii, 6 parts of Radix Scutellariaes, 4.5 parts of Fructus Momordicaes, 6 parts, Folium Mori.
The production method that above-mentioned each component is made to medicine of the present invention is to adopt one kettle way to make, that is, and and after all medicaments are mixed, add water to 1～2 times of medicine gross weight, soak 30min, at 110～120 DEG C, heat 20min, then reduce temperature to 100～105 DEG C, continue heating 20min, then temperature to 110～120 DEG C that raise, continue heating 10min, be again cooled to 80～90 DEG C, heating 10min, cooling, filter, remove slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into thick paste shape extractum, and dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, makes tablet or pill after sterilizing.
Or by above-mentioned gained extractum, dry and pulverize, after adding adjuvant and being mixed, granulate, after dry sterilization, pack granulation agent.
Its pharmacological action of the formula that foregoing invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, the redox state of epi-nutgall base catechin and gallate scalable cell regulates and controls the phosphorylation for gene and the protein-tyrosine of the glyconeogenesis enzyme of encoding, affect the kinase activity of islet secretion, significantly hypoglycemic activity.Radix Pternopetali vulgaris cold expelling regulating QI to relieve pain, strengthening spleen, tonifying kidney, Radix Puerariae improves liver function, enhances metabolism, and blood falls in toxin expelling, regulates blood-fat and blood sugar, promotes hemopoietic, suppresses aldose reductase activity, affects pancreas B cell function.Flower thinning Cacumen Myricariae Germanicae dispelling wind to relieve the exterior syndrome, dispelling wind and removing obstruction in the collateral, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Herba Ecliptae, Radix Paeoniae Alba nourishing YIN to lower pathogenic fire, Semen Persicae, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Fructus Arctii, Cortex Lycii clearing away heat and cooling blood, fall asthenic fire clearly, Radix Scrophulariae consumption of YIN caused by febrile disease, crimson tongue excessive thirst, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, enters nutrient blood with controlling heat.Stomach is rushed down in Radix Scutellariae, Fructus Momordicae, Folium Mori lung heat clearing, removing heat from blood dampness, clearing heat and moistening lung, heat clearing and damp drying, eliminating fire and detoxication, hemostasis, blood pressure lowering.
The Chinese medicine that the formula of foregoing invention makes has the following advantages:
1. this formula is taking natural edible-plant medicine as raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 10 Zhou Houneng make blood glucose be reduced to normal level, within 70 weeks, can fully recover, and this medicine, without sweet taste, is cured tracing study in latter 6 months, is normally through hepatic and renal function inspection, human body is had no side effect, without toleration.
2. the prepared Chinese medicine for treating diabetes of formula of the present invention is without bitterness sense, can long-term taking, and sick the lighter, dose reduces by half, and sick severe one can be according to aggravation dose, can not cause because dosage is excessive blood glucose to be reduced to below normal value, causes hypoglycemia.
3. formula peroxide activator enzyme body proliferator activated receptor γ of the present invention (PPAR γ), strengthen insulin sensitivity sexual type, improve the level of Insulin receptor INSR β protein subunit, improve the level of Insulin receptor INSR, improve the sensitivity of target cell to insulin, further improve insulin resistant.Regulate the activity of desmoenzyme system to carry out regulation and control substance metabolism, promote the differentiation of adipose cell, increase glucose transport vector contg.This formula can use with other antidiabetic drugs and insulin combination, but can greatly reduce the dosage of antidiabetic drug and insulin, and therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. formula YIN nourishing and the production of body fluid promoting of the present invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can further be taken foot bath, takes and is used in conjunction with treatment diabetes with this.
For showing that the formula of foregoing invention is to the therapeutic effect of diabetes, the present invention selects patient's 92 examples that medical history, the state of an illness, age, sex and former Therapeutic Method are suitable to observe for system temporarily, is divided at random 2 groups.Treatment group 58 examples, male 33 examples, female's 25 examples; 38.8～77.4 years old age, average (58.1 ± 19.3) year; Diabetic duration 3.9～16.4 years, average (10.15 ± 6.25) year; Diabetic duration 0.48～5.7 year, average (3.09 ± 2.61) year.Matched group 34 examples, male 14 examples, female's 20 examples; 43.3～74.6 years old age, average (58.95 ± 15.65) year; Diabetic duration 2.8～20.5 years, average (11.65 ± 8.85) year; Diabetic duration 0.6～10.4 year, average (5.5 ± 4.9) year.The aspect comparisons such as 2 groups of patient ages, sex, the course of disease, the state of an illness, difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 2 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the application's matched group antidiabetic drug adopts diabetes pill.
Detection method is regularly to detect fasting glucose (FPG), 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situation after the meal.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 5 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 6 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
The diversity that above-mentioned Chinese medicine formula reduces blood sugar content is as can be seen from Table 5 remarkable, this difference tool is very significant (P < 0.01), take after 3 months, blood sugar content is reduced to normal level, but, this Chinese medicine Chinese medicine formula compared with diabetes pill substantially without significant differences (P >=0.05); As can be seen from Table 6, take Chinese medicine formula of the present invention, before and after cholesterol and triglyceride, content obviously reduces, this difference tool is very significant (P < 0.01), and the index of cholesterol and triglyceride reaches normal level, and insulin content, front and back significant difference, its difference has significant (P < 0.01), and after 3 months, insulin content reaches normal level.Take formula of the present invention after 70 weeks, glucose in urine content significance reduces, this content belongs to normal urine sugar value, described in patient, the phenomenon of polyphagia, polydipsia, polyuria has not had, and body weight also reaches normal level gradually, the cure rate of diabetes reaches 99%, through the tracing study of 6 months, hepatic and renal function was normally, does not find toxic and side effects.Illustrate and take Chinese medicine formula of the present invention, may stimulate or promote insulin secretion, promote cholesterol and triglyceride to decompose, reach gradually normal level.
A further object of the present invention is to provide a kind of Chinese medicine formula for the treatment of diabetes, belongs to Inhibiting α-glucosidase active form Chinese medicine formula, and Chinese medicine ingredients and weight portion are: Radix Ginseng 4-9 part, tea polyphenols 6-9 part, Rhizoma amorphophalli 4-9 part, money Fructus Chaenomelis 4-9 part, Radix Ophiopogonis 2-5 part, Herba Ecliptae 3-7 part, Semen Persicae 2-6 part, Rhizoma Dioscoreae 5-9 part, Radix Cyathulae 3-6 part, Cortex Moutan 5-10 part skin, Fructus Schisandrae Chinensis 3-5 part, berberine 5-9 part, Radix Scrophulariae 3-6 part, Folium Mori 2-8 part, Cortex Lycii 2-8 part, Radix Rehmanniae 3-6 part, Radix Trichosanthis 3-6 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 6-9 part, tea polyphenols 6-8 part, Rhizoma amorphophalli 6-9 part, money Fructus Chaenomelis 6-9 part, Radix Ophiopogonis 3-5 part, Herba Ecliptae 3-5 part, Semen Persicae 4-6 part, Rhizoma Dioscoreae 6-8 part, Radix Cyathulae 3-5 part, Cortex Moutan 7-9 part skin, Fructus Schisandrae Chinensis 3-5 part, berberine 6-9 part, Radix Scrophulariae 4-6 part, Folium Mori 6-8 part, Cortex Lycii 6-8 part, Radix Rehmanniae 4-6 part, Radix Trichosanthis 4-6 part.
Further Chinese medicine ingredients and weight portion are: 6.8 parts of Radix Ginsengs, 6.8 parts of tea polyphenols, 6 parts of Rhizoma amorphophallis, 7 parts of money Fructus Chaenomeliss, 3 parts of Radix Ophiopogonis, 5 parts of Herba Ecliptaes, 4 parts, Semen Persicae, 7.5 parts of Rhizoma Dioscoreaes, 4.5 parts of Radix Cyathulaes, 8 parts of skins of Cortex Moutan, 4 parts of Fructus Schisandrae Chinensis, 6.8 parts of berberines, 4.5 parts of Radix Scrophulariaes, 6 parts, Folium Mori, 6 parts of Cortex Lycii, 4.5 parts, the Radix Rehmanniae, 4.5 parts of Radix Trichosanthis.
The production method that above-mentioned each component is made to medicine of the present invention is to adopt one kettle way to make, that is, and and after all medicaments are mixed, add water to 1～2 times of medicine gross weight, soak 30min, at 110～120 DEG C, heat 20min, then reduce temperature to 100～105 DEG C, continue heating 20min, then temperature to 110～120 DEG C that raise, continue heating 10min, be again cooled to 80～90 DEG C, heating 10min, cooling, filter, remove slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into thick paste shape extractum, and dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, makes tablet or pill after sterilizing.
Or by above-mentioned gained extractum, dry and pulverize, after adding adjuvant and being mixed, granulate, after dry sterilization, pack granulation agent.Its pharmacological action of the formula that the present invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, tea polyphenols Inhibiting α-glucosidase activity, α-amylase is also had to certain inhibitory action, can reduce glucose transport activity simultaneously, delay or slow down sugared digestion and absorption, thereby improve its carbohydrate tolerance.Rhizoma amorphophalli delay glucose and fatty absorption, dietary fiber can promote that cholesterol is converted into cholic acid, reduces cholic acid circulation, reduces cholesterol.Money Fructus Chaenomelis suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Herba Ecliptae nourishing YIN to lower pathogenic fire, Rhizoma Dioscoreae tonifying spleen-yin and consolidating semen is micro-, Semen Persicae, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Radix Scrophulariae consumption of YIN caused by febrile disease, crimson tongue excessive thirst, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, enters nutrient blood with controlling heat.Stomach is rushed down in berberine, the Radix Rehmanniae, Folium Mori, Cortex Lycii lung heat clearing, removing heat from blood dampness, and clearing heat and moistening lung, heat clearing and damp drying, clearing away heat and cooling blood, falls asthenic fire clearly, eliminating fire and detoxication, hemostasis, blood pressure lowering, Radix Trichosanthis promoting the production of body fluid to quench thirst.
The Chinese medicine that the formula of foregoing invention makes has the following advantages:
1. this formula is taking natural edible-plant medicine as raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 9 Zhou Houneng make blood glucose be reduced to normal level, within 60 weeks, can fully recover, and this medicine, without sweet taste, is cured tracing study in latter 6 months, is normally through hepatic and renal function inspection, human body is had no side effect, without toleration.
2. the prepared Chinese medicine for treating diabetes of formula of the present invention is without bitterness sense, can long-term taking, and sick the lighter, dose reduces by half, and sick severe one can be according to aggravation dose, can not cause because dosage is excessive blood glucose to be reduced to below normal value, causes hypoglycemia.
3. formula Inhibiting α-glucosidase activity of the present invention, delay glucose absorbs, and the fat increase that post-prandial glycemia and surfeit carbohydrate are caused has antagonism, promotes insulin to recover, protection pancreas, this blood sugar reducing function can increase the sugar tolerance of human body.This formula can use with other antidiabetic drugs and insulin combination, but can greatly reduce the dosage of antidiabetic drug and insulin, and therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. formula YIN nourishing and the production of body fluid promoting of the present invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can further be taken foot bath, takes and is used in conjunction with treatment diabetes with this.For showing the therapeutic effect of foregoing invention medicine to diabetes, the present invention selects patient's 83 examples that medical history, the state of an illness, age, sex and former Therapeutic Method are suitable to observe for system temporarily, is divided at random 2 groups.Treatment group 48 examples, male 38 examples, female's 21 examples; 36.4～80 years old age, average (58.2 ± 21.8) year; Diabetic duration 4.8～20 years, average (12.4 ± 7.6) year; Diabetic duration 1.2～7.4 years, average (4.3 ± 3.1) year.Matched group 35 examples, male 17 examples, female's 18 examples; 42.5～75.3 years old age, average (58.9 ± 16.4) year; Diabetic duration 6.6～19.7 years, average (13.15 ± 6.55) year; Diabetic duration 0.8～8.2 year, average (5.75 ± 2.45) year.The aspect comparisons such as 2 groups of patient ages, sex, the course of disease, the state of an illness, difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 2 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the application's matched group antidiabetic drug adopts diabetes pill.
Detection method is regularly to detect fasting glucose (FPG), 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situation after the meal.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 7 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 8 is for adopting the difference comparison of 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
The diversity that this Chinese medicine formula reduces blood sugar content is as can be seen from Table 7 remarkable, FPG drops to 3.6 ± 1.29mmol/L from 18.56 ± 2.85, 2hPG drops to 4.44 ± 2.02 from 24.8 ± 2.22, this difference tool is very significant (P < 0.01), and Chinese medicine formula also has significant difference (P < 0.01) compared with diabetes pill, take the Chinese medicine of above-mentioned formula, blood sugar content just can drop to normal level, described in patient, polyphagia, polydipsia, the phenomenon of polyuria has not had, body weight also reaches normal level gradually.As can be seen from Table 8, take Chinese medicine formula of the present invention, after 3 months, before and after cholesterol and triglyceride, content obviously reduces, this difference tool is very significant (P < 0.01), and insulin content, front and back significant difference, its difference has significant (P < 0.01).After 60 weeks, the cure rate of diabetes reaches 95.5%, and through the tracing study of 6 months, hepatic and renal function was normally, does not find toxic and side effects.
Detailed description of the invention
Embodiment 1
Treat a Chinese medicine formula for diabetes, belong to and reduce blood glucose type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 2.5g, Radix Ophiopogonis 2.5g, Rhizoma Dioscoreae 5.8g, Rhizoma Anemarrhenae 5.8g, Fructus Ligustri Lucidi 5.8g, Herba Ecliptae 3.6g, Rhizoma Atractylodis Macrocephalae (parched) 5.8g, Radix Astragali 3.6g, Semen Persicae 2.5g, Radix Paeoniae Rubra 5.8g, Cortex Moutan 5.8g, Radix Cyathulae 3.6g, Fructus Arctii 3.6g, Radix Rehmanniae 5.8g, Cortex Lycii 3.6g, Radix Trichosanthis 3.6g.
Embodiment 2
Treat a Chinese medicine formula for diabetes, belong to and reduce blood glucose type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 5.7g, Radix Ophiopogonis 5.5g, Rhizoma Dioscoreae 8.8g, Rhizoma Anemarrhenae 8.8g, Fructus Ligustri Lucidi 9.2g, Herba Ecliptae 7g, Rhizoma Atractylodis Macrocephalae (parched) 9.2g, Radix Astragali 7g, Semen Persicae 6.5g, Radix Paeoniae Rubra 9.2g, Cortex Moutan 9.2g, Radix Cyathulae 7g, Fructus Arctii 6.5g, Radix Rehmanniae 9.2g, Cortex Lycii 7g, Radix Trichosanthis 7g.
Embodiment 3
Treat a Chinese medicine formula for diabetes, belong to and reduce blood glucose type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 4.5g, Radix Ophiopogonis 5.7g, Rhizoma Dioscoreae 9.5g, Rhizoma Anemarrhenae 9.5g, Fructus Ligustri Lucidi 9.5g, Herba Ecliptae 6g, Rhizoma Atractylodis Macrocephalae (parched) 9.5g, Radix Astragali 6.8g, Semen Persicae 5g, Radix Paeoniae Rubra 9.5g, Cortex Moutan 9.5g, Radix Cyathulae 6.8g, Fructus Arctii 6g, Radix Rehmanniae 9.5g, Cortex Lycii 6.8g, Radix Trichosanthis 6g.
Embodiment 4
Treat a Chinese medicine formula for diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 4.5g, Herba Ephedrae alkaloid 2.8g, Pollen Typhae ketone 2.5g, Radix Angelicae Pubescentis 2.5g, β-eucalyptus leaves oleyl alcohol 4.5g, Radix Pternopetali vulgaris 3.8g, Radix Puerariae 3.8g, Rhizoma Anemarrhenae 4.5g, Fructus Ligustri Lucidi 4.5g, Herba Ecliptae 5.8g, Rhizoma Atractylodis Macrocephalae (parched) 5.8g, Semen Persicae 2.8g, Cortex Moutan 5.5g, Radix Cyathulae 3.8g, Fructus Arctii 3.8g, Radix Scrophulariae 4.5g, Cortex Lycii 3.8g, Herba Leonuri 3g.
Embodiment 5
Treat a Chinese medicine formula for diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 7g, Herba Ephedrae alkaloid 6g, Pollen Typhae ketone 4g, Radix Angelicae Pubescentis 3g, β-eucalyptus leaves oleyl alcohol 7g, Radix Pternopetali vulgaris 7g, Radix Puerariae 6.5g, Rhizoma Anemarrhenae 6g, Fructus Ligustri Lucidi 6g, Herba Ecliptae 6g, Rhizoma Atractylodis Macrocephalae (parched) 7.5g, Semen Persicae 2.5g, Cortex Moutan 7g, Radix Cyathulae 5g, Fructus Arctii 4g, Radix Scrophulariae 4g, Cortex Lycii 5g, Herba Leonuri 7g.
Embodiment 6
Treat a Chinese medicine formula for diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 6.5g, Herba Ephedrae alkaloid 5.5g, Pollen Typhae ketone 4g, Radix Angelicae Pubescentis 3g, β-eucalyptus leaves oleyl alcohol 6.5g, Radix Pternopetali vulgaris 7g, Radix Puerariae 5.8g, Rhizoma Anemarrhenae 6g, Fructus Ligustri Lucidi 6g, Herba Ecliptae 6g, Rhizoma Atractylodis Macrocephalae (parched) 7g, Semen Persicae 3.8g, Cortex Moutan 7.5g, Radix Cyathulae 4.5g, Fructus Arctii 4.5g, Radix Scrophulariae 5.5g, Cortex Lycii 4.5g, Herba Leonuri 5g.
Embodiment 7
Treat a Chinese medicine formula for diabetes, belong to the Chinese medicine formula that strengthens insulin sensitivity sexual type, Chinese medicine ingredients and weight are: Radix Ginseng 3.5g, epi-nutgall base catechin and gallate 4.8g, flower thinning Cacumen Myricariae Germanicae 3.8g, Radix Pternopetali vulgaris 6.5g, Radix Ophiopogonis 3.5g, Herba Ecliptae 3.8g, Radix Paeoniae Alba 3.8g, Semen Persicae 6.0g, Cortex Moutan 3.8g, Radix Cyathulae 3.8g, Fructus Arctii 3.8g, Radix Scrophulariae 4.5g, Cortex Lycii 3.8g, Radix Scutellariae 4.5g, Fructus Momordicae 33.8g, Folium Mori 4.5g.
Embodiment 8
Treat a Chinese medicine formula for diabetes, belong to the Chinese medicine formula that strengthens insulin sensitivity sexual type, Chinese medicine ingredients and weight are: Radix Ginseng 6.5g, epi-nutgall base catechin and gallate 8g, flower thinning Cacumen Myricariae Germanicae 4.5g, Radix Pternopetali vulgaris 8g, Radix Ophiopogonis 4g, Herba Ecliptae 6g, Radix Paeoniae Alba 6g, Semen Persicae 7g, Cortex Moutan 3.5g, Radix Cyathulae 3.5g, Fructus Arctii 6g, Radix Scrophulariae 6g, Cortex Lycii 5g, Radix Scutellariae 7g, Fructus Momordicae 3g, Folium Mori 8g.
Embodiment 9
Treat a Chinese medicine formula for diabetes, belong to the Chinese medicine formula that strengthens insulin sensitivity sexual type, Chinese medicine ingredients and weight are: Radix Ginseng 7g, epi-nutgall base catechin and gallate 9g, flower thinning Cacumen Myricariae Germanicae 6g, Radix Pternopetali vulgaris 6g, Radix Ophiopogonis 3g, Herba Ecliptae 5g, Radix Paeoniae Alba 5g, Semen Persicae 8.5g, Cortex Moutan 4.8g, Radix Cyathulae 4.8g, Fructus Arctii 4.8g, Radix Scrophulariae 5.5g, Cortex Lycii 4.5g, Radix Scutellariae 6g, Fructus Momordicae 4.5g, Folium Mori 6g.
Embodiment 10
Treat a Chinese medicine formula for diabetes, belong to Inhibiting α-glucosidase active form Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 4g, tea polyphenols 6g, Rhizoma amorphophalli 4g, money Fructus Chaenomelis 4.5g, Radix Ophiopogonis 2.5g, Herba Ecliptae 3.5g, Semen Persicae 2.8g, Rhizoma Dioscoreae 5g, Radix Cyathulae 3g, Cortex Moutan 6g, Fructus Schisandrae Chinensis 3.8g, berberine 5g, Radix Scrophulariae 3.8g, Folium Mori 2.8g, Cortex Lycii 2.8g, Radix Rehmanniae 3.5g, Radix Trichosanthis 3.5g.
Embodiment 11
Treat a Chinese medicine formula for diabetes, belong to Inhibiting α-glucosidase active form Chinese medicine formula, Chinese medicine ingredients and weight are: 9 parts of Radix Ginsengs, 8 parts of tea polyphenols, 9 parts of Rhizoma amorphophallis, money Fructus Chaenomelis 9g, Radix Ophiopogonis 5g, Herba Ecliptae 5g, Semen Persicae 6g, Rhizoma Dioscoreae 6g, Radix Cyathulae 5g, Cortex Moutan 9g, Fructus Schisandrae Chinensis 5g, berberine 9g, Radix Scrophulariae 6g, Folium Mori 8g, Cortex Lycii 8g, Radix Rehmanniae 6g, Radix Trichosanthis 6g.
Embodiment 12
Treat a Chinese medicine formula for diabetes, belong to Inhibiting α-glucosidase active form Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 6.8g, tea polyphenols 6.8g, Rhizoma amorphophalli 6g, money Fructus Chaenomelis 7g, Radix Ophiopogonis 3g, Herba Ecliptae 5g, Semen Persicae 4g, Rhizoma Dioscoreae 7.5g, Radix Cyathulae 4.5g, Cortex Moutan 8g, Fructus Schisandrae Chinensis 4g, berberine 6.8g, Radix Scrophulariae 4.5g, Folium Mori 6g, Cortex Lycii 6g, Radix Rehmanniae 4.5g, Radix Trichosanthis 4.5g.
Embodiment 13
Adopt one kettle way to make Chinese medicine formula of the present invention every medicine, that is, and after all medicaments are mixed, add water to 1～2 times of medicine gross weight, soak 30min, at 110～120 DEG C, heat 20min, then reduce temperature to 100～105 DEG C, continue heating 20min, then temperature to 110～120 DEG C that raise, continue heating 10min, be again cooled to 80～90 DEG C, heating 10min, cooling, filter, remove slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into thick paste shape extractum, and dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, makes tablet or pill after sterilizing.
Or by above-mentioned gained extractum, dry and pulverize, after adding adjuvant and being mixed, granulate, after dry sterilization, pack granulation agent.
Claims (14)
1. a Chinese medicine for the treatment of diabetes, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 2-6 part, Radix Ophiopogonis 2-6 part, Rhizoma Dioscoreae 5-10 part, Rhizoma Anemarrhenae 5-10 part, Fructus Ligustri Lucidi 5-10 part, Herba Ecliptae 3-8 part, Rhizoma Atractylodis Macrocephalae (parched) 5-10 part, Radix Astragali 3-8 part, Semen Persicae 2-7 part, Radix Paeoniae Rubra 5-10 part, Cortex Moutan 5-11 part, Radix Cyathulae 3-8 part, Fructus Arctii 3-8 part, Radix Rehmanniae 5-11 part, Cortex Lycii 3-8 part, Radix Trichosanthis 3-8 part.
2. the Chinese medicine for the treatment of diabetes according to claim 1, is characterized in that, composition and weight portion are: Radix Ginseng 4-6 part, Radix Ophiopogonis 4-6 part, Rhizoma Dioscoreae 8-10 part, Rhizoma Anemarrhenae 8-10 part, Fructus Ligustri Lucidi 8-10 part, Herba Ecliptae 5-8 part, Rhizoma Atractylodis Macrocephalae (parched) 8-10 part, Radix Astragali 6-8 part, Semen Persicae 4-7 part, Radix Paeoniae Rubra 8-10 part, Cortex Moutan 8-11 part, Radix Cyathulae 6-8 part, Fructus Arctii 5-8 part, Radix Rehmanniae 8-11 part, Cortex Lycii 6-8 part, Radix Trichosanthis 6-8 part.
3. the Chinese medicine for the treatment of diabetes according to claim 1, is characterized in that, Chinese medicine ingredients and weight portion are: 5.7 parts of Radix Ginsengs, 5.7 parts of Radix Ophiopogonis, 9.5 parts of Rhizoma Dioscoreaes, 9.5 parts of the Rhizoma Anemarrhenaes, 9.5 parts of Fructus Ligustri Lucidi, 6 parts of Herba Ecliptaes, 9.5 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 6.8 parts of the Radixs Astragali, 5 parts, Semen Persicae, 9.5 parts of Radix Paeoniae Rubra, 9.5 parts of Cortex Moutans, 6.8 parts of Radix Cyathulaes, 6 parts of Fructus Arctiis, 9.5 parts, the Radix Rehmanniae, 6.8 parts of Cortex Lycii, 6 parts of Radix Trichosanthis.
4. a Chinese medicine for the treatment of diabetes, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 4-8 part, Herba Ephedrae alkaloid 2-7 part, Pollen Typhae ketone 2-5 part, Radix Angelicae Pubescentis 2-5 part, β-eucalyptus leaves oleyl alcohol 4-8 part, Radix Pternopetali vulgaris 3-9 part, Radix Puerariae 3-9 part, Rhizoma Anemarrhenae 4-8 part, Fructus Ligustri Lucidi 4-8 part, Herba Ecliptae 5-10 part, Rhizoma Atractylodis Macrocephalae (parched) 5-9 part, Semen Persicae 2-5 part, Cortex Moutan 5-9 part, Radix Cyathulae 3-6 part, Fructus Arctii 3-6 part, Radix Scrophulariae 4-8 part, Cortex Lycii 3-6 part, Herba Leonuri 2-7 part.
5. the Chinese medicine for the treatment of diabetes according to claim 4, it is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 6-8 part, Herba Ephedrae alkaloid 5-7 part, Pollen Typhae ketone 3.5-5 part, Radix Angelicae Pubescentis 2-3.5 part, β-eucalyptus leaves oleyl alcohol 6-8 part, Radix Pternopetali vulgaris 6.5-8 part, Radix Puerariae 5-7 part, Rhizoma Anemarrhenae 5-6.5 part, Fructus Ligustri Lucidi 5-7 part, Herba Ecliptae 5-7 part, Rhizoma Atractylodis Macrocephalae (parched) 6.5-7.8 part, Semen Persicae 2.5-4.2 part, Cortex Moutan 6.8-8.5 part, Radix Cyathulae 4-5.5 part, Fructus Arctii 4-6 part, Radix Scrophulariae 4-6 part, Cortex Lycii 3-5 part, Herba Leonuri 5-7 part.
6. the Chinese medicine for the treatment of diabetes according to claim 4, is characterized in that, Chinese medicine ingredients and weight portion are: 6.5 parts of Radix Ginsengs, 5.5 parts of Herba Ephedrae alkaloids, 4 parts of Pollen Typhae ketone, 3 parts of Radix Angelicae Pubescentiss, 6.5 parts of β-eucalyptus leaves oleyl alcohol, 7 parts of Radix Pternopetali vulgariss, 5.8 parts of Radix Puerariaes, 6 parts of the Rhizoma Anemarrhenaes, 6 parts of Fructus Ligustri Lucidi, 6 parts of Herba Ecliptaes, 7 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 3.8 parts, Semen Persicae, 7.5 parts of Cortex Moutans, 4.5 parts of Radix Cyathulaes, 4.5 parts of Fructus Arctiis, 5.5 parts of Radix Scrophulariaes, 4.5 parts of Cortex Lycii, 5 parts of Herba Leonuris.
7. a Chinese medicine for the treatment of diabetes, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 2-8 part, epi-nutgall base catechin and gallate 4-9 part, flower thinning Cacumen Myricariae Germanicae 3-6 part, Radix Pternopetali vulgaris 5-10 part, Radix Ophiopogonis 2-5 part, Herba Ecliptae 3-6 part, Radix Paeoniae Alba 3-6 part, Semen Persicae 5-9 part, Cortex Moutan 3-6 part, Radix Cyathulae 3-6 part, Fructus Arctii 3-6 part, Radix Scrophulariae 4-6 part, Cortex Lycii 3-6 part, Radix Scutellariae 4-8 part, Fructus Momordicae 3-6 part, Folium Mori 4-8 part.
8. the Chinese medicine for the treatment of diabetes according to claim 7, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 6-8 part, epi-nutgall base catechin and gallate 8-9 part, flower thinning Cacumen Myricariae Germanicae 4-6 part, Radix Pternopetali vulgaris 5-8 part, Radix Ophiopogonis 2-4 part, Herba Ecliptae 5-6 part, Radix Paeoniae Alba 5-6 part, Semen Persicae 7-9 part, Cortex Moutan 3-5 part, Radix Cyathulae 3-5 part, Fructus Arctii 4-6 part, Radix Scrophulariae 5-6 part, Cortex Lycii 3-5 part, Radix Scutellariae 5-7 part, Fructus Momordicae 3-5 part, Folium Mori 6-8 part.
9. the Chinese medicine for the treatment of diabetes according to claim 7, is characterized in that, Chinese medicine ingredients and weight portion are: 7 parts of Radix Ginsengs, 9 parts of epi-nutgall base catechin and gallates, 6 parts of flower thinning Cacumen Myricariae Germanicaes, 6 parts of Radix Pternopetali vulgariss, 3 parts of Radix Ophiopogonis, 5 parts of Herba Ecliptaes, 5 parts of the Radix Paeoniae Albas, 8.5 parts, Semen Persicae, 4.8 parts of Cortex Moutans, 4.8 parts of Radix Cyathulaes, 4.8 parts of Fructus Arctiis, 5.5 parts of Radix Scrophulariaes, 4.5 parts of Cortex Lycii, 6 parts of Radix Scutellariaes, 4.5 parts of Fructus Momordicaes, 6 parts, Folium Mori.
10. a Chinese medicine for the treatment of diabetes, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 4-9 part, tea polyphenols 6-9 part, Rhizoma amorphophalli 4-9 part, money Fructus Chaenomelis 4-9 part, Radix Ophiopogonis 2-5 part, Herba Ecliptae 3-7 part, Semen Persicae 2-6 part, Rhizoma Dioscoreae 5-9 part, Radix Cyathulae 3-6 part, Cortex Moutan 5-10 part, Fructus Schisandrae Chinensis 3-5 part, berberine 5-9 part, Radix Scrophulariae 3-6 part, Folium Mori 2-8 part, Cortex Lycii 2-8 part, Radix Rehmanniae 3-6 part, Radix Trichosanthis 3-6 part.
The Chinese medicine of 11. treatment diabetes according to claim 10, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 6-9 part, tea polyphenols 6-8 part, Rhizoma amorphophalli 6-9 part, money Fructus Chaenomelis 6-9 part, Radix Ophiopogonis 3-5 part, Herba Ecliptae 3-5 part, Semen Persicae 4-6 part, Rhizoma Dioscoreae 6-8 part, Radix Cyathulae 3-5 part, Cortex Moutan 7-9 part, Fructus Schisandrae Chinensis 3-5 part, berberine 6-9 part, Radix Scrophulariae 4-6 part, Folium Mori 6-8 part, Cortex Lycii 6-8 part, Radix Rehmanniae 4-6 part, Radix Trichosanthis 4-6 part.
The Chinese medicine of 12. treatment diabetes according to claim 10, is characterized in that, Chinese medicine ingredients and weight portion are: 6.8 parts of Radix Ginsengs, 6.8 parts of tea polyphenols, 6 parts of Rhizoma amorphophallis, 7 parts of money Fructus Chaenomeliss, 3 parts of Radix Ophiopogonis, 5 parts of Herba Ecliptaes, 4 parts, Semen Persicae, 7.5 parts of Rhizoma Dioscoreaes, 4.5 parts of Radix Cyathulaes, 8 parts of Cortex Moutans, 4 parts of Fructus Schisandrae Chinensis, 6.8 parts of berberines, 4.5 parts of Radix Scrophulariaes, 6 parts, Folium Mori, 6 parts of Cortex Lycii, 4.5 parts, the Radix Rehmanniae, 4.5 parts of Radix Trichosanthis.
13. according to the Chinese medicine of any one treatment diabetes described in claim 1-12, it is characterized in that, the prepared medicament of this Chinese medicine is decoction, tablet, pill, any one in granule.
The Chinese medicine of 14. treatment diabetes according to claim 13, employing one kettle way makes, and it is characterized in that, after all medicaments are mixed, add water to 1 ~ 2 times of medicine gross weight, soak 30min, at 110 ~ 120 DEG C, heat 20min, then reduce temperature to 100 ~ 105 DEG C, continue heating 20min, cooling, filter, remove slag and make oral liquid; Maybe this oral liquid heating is concentrated into thick paste shape extractum, dries, beat powder and make tablet, pill or granule.
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| CN201510003136.2A CN104606474B (en) | 2014-04-01 | 2014-04-01 | Treat the Chinese medicine of diabetes |
| CN201410129241.6A CN103948786B (en) | 2014-04-01 | 2014-04-01 | Traditional Chinese medicine for treating diabetes |
| CN201510002530.4A CN104587175B (en) | 2014-04-01 | 2014-04-01 | A kind of Chinese medicine preparation for treating diabetes |
| CN201510003701.5A CN104587176B (en) | 2014-04-01 | 2014-04-01 | Treat the medicine of diabetes |
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| CN201510003136.2A Division CN104606474B (en) | 2014-04-01 | 2014-04-01 | Treat the Chinese medicine of diabetes |
| CN201510003701.5A Division CN104587176B (en) | 2014-04-01 | 2014-04-01 | Treat the medicine of diabetes |
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| CN104432024A (en) * | 2014-11-04 | 2015-03-25 | 天津大学 | Traditional Chinese medicine composition having hypoglycemic effect |
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| CN105770394A (en) * | 2016-03-14 | 2016-07-20 | 杜伯君 | Diabetes treatment medicine |
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| CN105194342B (en) * | 2015-10-26 | 2018-10-23 | 冯天宁 | It is a kind of to treat Chinese medicine for treating diabetes composition |
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| CN109157617A (en) * | 2018-11-28 | 2019-01-08 | 王钦义 | A kind of Chinese medicine composition for treating diabetes |
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| CN103948786B (en) | 2015-02-04 |
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