CN103860937A - Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine - Google Patents
Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine Download PDFInfo
- Publication number
- CN103860937A CN103860937A CN201410111029.7A CN201410111029A CN103860937A CN 103860937 A CN103860937 A CN 103860937A CN 201410111029 A CN201410111029 A CN 201410111029A CN 103860937 A CN103860937 A CN 103860937A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- fructus
- percent
- composition
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 48
- 239000000126 substance Substances 0.000 title claims abstract description 30
- 231100000753 hepatic injury Toxicity 0.000 title abstract description 6
- 206010067125 Liver injury Diseases 0.000 title abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 48
- 210000004185 liver Anatomy 0.000 claims abstract description 41
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 208000024891 symptom Diseases 0.000 claims abstract description 8
- 241000628997 Flos Species 0.000 claims description 35
- 230000001681 protective effect Effects 0.000 claims description 20
- 210000000582 semen Anatomy 0.000 claims description 18
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 17
- 239000002994 raw material Substances 0.000 claims description 11
- 239000002131 composite material Substances 0.000 claims description 9
- 230000036541 health Effects 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 65
- 230000000694 effects Effects 0.000 abstract description 37
- 235000019441 ethanol Nutrition 0.000 abstract description 31
- 210000000952 spleen Anatomy 0.000 abstract description 13
- 210000002784 stomach Anatomy 0.000 abstract description 13
- 230000001737 promoting effect Effects 0.000 abstract description 9
- 230000004087 circulation Effects 0.000 abstract description 3
- 230000007812 deficiency Effects 0.000 abstract description 3
- 244000197580 Poria cocos Species 0.000 abstract description 2
- 235000008599 Poria cocos Nutrition 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 244000025254 Cannabis sativa Species 0.000 abstract 1
- 235000007516 Chrysanthemum Nutrition 0.000 abstract 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract 1
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract 1
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 1
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract 1
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 1
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract 1
- 241001598107 Imperata Species 0.000 abstract 1
- 244000241872 Lycium chinense Species 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 240000002853 Nelumbo nucifera Species 0.000 abstract 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 28
- 238000003304 gavage Methods 0.000 description 15
- 230000001154 acute effect Effects 0.000 description 12
- 230000028527 righting reflex Effects 0.000 description 11
- 208000007848 Alcoholism Diseases 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 201000007930 alcohol dependence Diseases 0.000 description 9
- 230000035622 drinking Effects 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 230000002567 autonomic effect Effects 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 7
- 230000029087 digestion Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 7
- 239000003440 toxic substance Substances 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 230000008673 vomiting Effects 0.000 description 7
- 206010047700 Vomiting Diseases 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 208000002173 dizziness Diseases 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 4
- 206010003084 Areflexia Diseases 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 240000006394 Sorghum bicolor Species 0.000 description 4
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 4
- 206010043458 Thirst Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 206010061428 decreased appetite Diseases 0.000 description 4
- 238000001784 detoxification Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 208000005374 Poisoning Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010067171 Regurgitation Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- -1 amino, amino Chemical group 0.000 description 3
- 208000022531 anorexia Diseases 0.000 description 3
- 230000036983 biotransformation Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 229940046011 buccal tablet Drugs 0.000 description 3
- 239000006189 buccal tablet Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 208000035861 hematochezia Diseases 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 231100000572 poisoning Toxicity 0.000 description 3
- 230000000607 poisoning effect Effects 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 208000004930 Fatty Liver Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010019708 Hepatic steatosis Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- 244000202052 Poncirus trifoliata Species 0.000 description 2
- 235000000404 Poncirus trifoliata Nutrition 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000002075 anti-alcohol Effects 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 231100000481 chemical toxicant Toxicity 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 231100000739 chronic poisoning Toxicity 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 208000010706 fatty liver disease Diseases 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 230000002443 hepatoprotective effect Effects 0.000 description 2
- 208000021760 high fever Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 210000004916 vomit Anatomy 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010054196 Affect lability Diseases 0.000 description 1
- 206010001605 Alcohol poisoning Diseases 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 102100031416 Gastric triacylglycerol lipase Human genes 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010019668 Hepatic fibrosis Diseases 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
- 206010034811 Pharyngeal cancer Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- RMMPZDDLWLALLJ-UHFFFAOYSA-N Thermophillin Chemical compound COC1=CC(=O)C(OC)=CC1=O RMMPZDDLWLALLJ-UHFFFAOYSA-N 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000003035 anti-peroxidant effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229940097572 chloromycetin Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 229930003949 flavanone Natural products 0.000 description 1
- 150000002207 flavanone derivatives Chemical class 0.000 description 1
- 235000011981 flavanones Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 108010091264 gastric triacylglycerol lipase Proteins 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 210000002767 hepatic artery Anatomy 0.000 description 1
- 210000002989 hepatic vein Anatomy 0.000 description 1
- 231100000334 hepatotoxic Toxicity 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 201000005264 laryngeal carcinoma Diseases 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 230000007056 liver toxicity Effects 0.000 description 1
- 239000008518 lycium barbarum polysaccharide Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003993 organochlorine pesticide Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000003864 performance function Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 208000010540 rapid respiration Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine with a function of protecting chemical liver injury and an application of the traditional Chinese medicine. The medicinal/edible traditional Chinese medicine comprises the following steps in percentage by weight: 5.93-14.81 percent of flower of kudzuvine, 7.41-18.52 percent of turnjujube, 7.41-18.52 percent of hawthorn, 7.41-22.22 percent of poria cocos, 7.41-22.22 percent of lalang grass rhizome, 5.93-14.81 percent of lotus leaf, 7.41-18.52 percent of chrysanthemum, 7.41-18.52 percent of fruit of Chinese wolfberry and 7.41-18.52 percent of smoked plum. The traditional Chinese medicine has a function of protecting liver injury caused by ethyl alcohol and can reach the purposes of dispelling the effects of alcohol and nourishing liver and stomach, has the efficacies of promoting the circulation of qi, alleviating water retention, tonifying deficiency, protecting stomach and refreshing the spleen, treats both symptoms and root causes, and is safe and effective pure Chinese medicine composition preparation.
Description
Technical field
The present invention relates to a kind ofly for chemical liver being had to the Chinese medicine composition of protective effect, be specifically related to a kind of Chinese medicine composition and application thereof that chemical liver is had to protective effect.
Background technology
Liver is that in digestion, maximum, most important digestion body of gland have important digestive function.Liver is also the main hemopoietic organ of fetus and the main metabolic organ of human body and defence organ.It implements its powerful defence function of detoxification generally to the external many harmful factors with metabolism generation of human body, and liver has very strong biotransformation, function of detoxification to external chemical toxicant.Wherein mainly contain following four kinds of modes: 1, oxidation removing toxic substances, if ethanol is the main harmful chemicals during many people drink, in body, through ethanol hydrogen enzyme, be oxidized in turn aldehyde and acid, other alcohols, aldehydes also become acid by this mode-conversion.Acid is combined into salt with other materials, and toxicity disappears, and gets rid of external.2, reduction and detoxication.For example industrial poison Nitrobenzol, nitro on phenyl ring is reducible is amino, amino toxicity is little more than the toxicity of nitro; The Chloral that hypnosis is used is reduced to ethapon and loses syngignoscism in liver, clinically the chloromycetin of use, once the organochlorine pesticide widely applied was all also that deoxidation and reduction is realized removing toxic substances in liver.3, hydrolysis removing toxic substances.Through the effect of hydrolytic enzyme, there is hydrolyzable in many harmful chemicals, change structure loses or destruction of toxic group and disappear or alleviated toxicity in conclusion.For example in body, H2O2, free radical, lipid peroxide all can lose illeffects after dissolving.4, in conjunction with toxicity.It is the main mode of liver toxicity removing toxic substances, often in conjunction with some polar groups, form water solublity larger material, alleviate or disappeared toxicity and get rid of external, for example Organic substance and carboxyl, with sulfate radical, with xanthogen, with glucuronic acid, with glycine, combining with glutathion etc., is all the important form of liver detoxification biotransformation.When this defence harmful factor is to body damage, itself also comes to harm liver unavoidably.Chemical liver injury is the hepatic injury being caused by chemical Hepatoxic substance.These chemical substances comprise chemical toxicant and the some drugs in ethanol, environment.As the liver of the important removing toxic substances organ of human body, there is Hepatic artery and hepatic vein double blood supply.Chemical substance can enter liver by gastrointestinal tract portal vein or body circulation and transform, and therefore liver is easily subject to the toxicant infringement in chemicals.Further investigation reveals that, in recent years due to the increase of social needs and social life pressure, excessive drinking and alcoholism have become the public health problem of China, ethanol has certain toxicity to liver, kidney, gastrointestinal tract, nervous system, blood circulation, and long-term excessive drinking causes the diseases such as mental disorder, gastric ulcer and liver fat, alcoholic hepatitis, liver cirrhosis.Also there are some data to show certain cancers, as the morbidity of oral cancer, pharyngeal cancer, laryngeal carcinoma, colon cancer and upper respiratory tract cancer and excessive consumption of alcohol also have substantial connection simultaneously.Acute a large amount of drinking can cause nausea, vomiting, hypomnesis, absent minded, psychomotor abilities is impaired and emotional instability, causes accident frequency rate to increase.The serious generation that even causes acute death.From ancient times to the present, people just attempt to adopt the whole bag of tricks to remove or alleviate toxic and side effects human body being produced after drinking, and therefore and constantly various antialcoholic drugs also come out, from fruit to corn, from food to medicine, rich and varied.The form of mainly utilizing Chinese herbal medicine to make Chinese medicine composition herein reaches relieves the effect of alcohol, and the object of stomach is protected in nourishing the liver.
In prior art, Chinese patent relieves the effect of alcohol as CN03111706, CN0610070068, CN0610125432, CN0810124841, CN0510012629 etc. disclose and fills a prescription and preparation method, the disclosed medicine of above-mentioned patent or patent medicine all has certain effect, but have little effect, people are still exploring better Chinese medicine formula, to improve people's health level, really play the effect of hepatoprotective.
Summary of the invention
In view of this; object of the present invention provides a kind of Chinese medicine composition that chemical liver is had to protective effect; be applied to the protection of chemical liver; to the excessive thirst of generating heat after drinking; anorexia; vomiting acid regurgitation, spits blood, and discharging fresh blood stool and the wine that disappears, dizziness, the loathing of cold, high fever, relieving acute alcoholism and recuperating the spleen, wine dysentery, diet are not thought, chest and diaphragm is glutted, send out oh, the symptom such as lung heat clearing improves significantly.
The Chinese medicine composition that chemical liver is had to protective effect of the present invention, composition material comprises following component by mass percentage: Flos puerariae lobatae 5.93-14.81%, Semen Hoveniae (Fructus Hoveniae) 7.41-18.52%, Fructus Crataegi 7.41-18.52%, Poria 7.41-22.22%, Rhizoma Imperatae 7.41-22.22%, Folium Nelumbinis 5.93-14.81%, Flos Chrysanthemi 7.41-18.52%, Fructus Lycii 7.41-18.52%, Fructus Mume 7.41-18.52%;
Further, said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7-14.81%, Semen Hoveniae (Fructus Hoveniae) 10-18.52%, Fructus Crataegi 10-18.52%, Poria 15-22.22%, Rhizoma Imperatae 15-22.22%, Folium Nelumbinis 7.41-14.81%, Flos Chrysanthemi 7.41-15.52%, Fructus Lycii 7.41-15.48%, Fructus Mume 7.41-15%;
Further, composition material comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%;
Further, when said composition is used, can add one or more for improving or treat the Chinese medicine of accompanied symptoms;
Further, said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation,
Comprise raw material can be obtained to extracting solution after selected, clean rear decoction, filtration respectively, further dilution forms oral liquid;
Comprise the extracting solution obtaining is further processed into granule;
Comprise the extracting solution obtaining is further processed into capsule;
Comprise the extracting solution obtaining is further processed into buccal tablet etc.
The present invention also discloses a kind of application that chemical liver is had to the Chinese medicine composition of protective effect, and said composition has chemical liver in the Chinese medicine of protective effect and applies in preparation.
Flos puerariae lobatae, nature and flavor are sweet, flat, enter spleen, stomach warp, have effect of relieving acute alcoholism and recuperating the spleen, are applicable to glutted swollen, the anorexia of insobriety, headache, dizziness, excessive thirst, breast belch, acid regurgitation, are the most representative antialcoholic drugs in traditional medicine.
Semen Hoveniae (Fructus Hoveniae), property is flat, sweet in the mouth.Enter through heart channel, spleen channel, have the relieving restlessness of quenching the thirst, disappear damp and hot, alcoholic intoxication.Be mainly used in middle alcoholism, excessive thirst vomiting, difficulty in urination and defecation; its energy accelerating alcohol metabolism; strengthen alcohol dehydrogenase activity; shorten the relieving alcoholic intoxication time; suppress alcohol induced flesh pine effect (the flavanone I of getting from Semen Hoveniae (Fructus Hoveniae); II; III (hovenitins I; II; III) alcohol induced flesh pine effect is had to inhibitory action); cholesterol, glycerol trioleate due to can Anti-ethanol increase, and to hepatic lipid peroxidation tool protective effect due to ethanol, may delay and prevent that the fatty liver due to ethanol from forming.
Described Fructus Crataegi, nature and flavor acid, sweet, tepor, returns spleen, stomach, Liver Channel, has promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis, can reduce the cholesterol level in blood and lipid is reduced in intraorganic deposition, has certain sober-up function.Secretion that can facilitating digestion enzyme, Fructus Crataegi is containing vitamin C, vitamin B2, carotene and multiple organic acid, the oral secretion that can increase digestive enzyme in stomach, and can strengthen the activity of enzyme, facilitating digestion, wherein contained lipase can directly help digest fat food, and can strengthen the activity of gastric lipase, protease.Fructus Crataegi has obvious Accommodation to gastrointestinal dysfunction, reaches strengthening the spleen to promote digestion effect.
Described Poria, property slightly sweet flavor is flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Poria cocos sclerotium is containing effective ingredient such as triterpenes and polysaccharide.
Described Rhizoma Imperatae, nature and flavor are sweet, cold, enter lung, stomach, urinary bladder channel.There is effect of cooling blood for hemostasis, clearing away heat and promoting diuresis.Cure mainly lung-heat dyspnea with rapid respiration, edema, jaundice and alcohol intoxication, can alcoholic intoxication.
Described Folium Nelumbinis bitter in the mouth is pungent micro-puckery, cool in nature, GUIXIN, liver, spleen channel, and delicate fragrance rises loose; There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, effect of dissipating blood stasis hemostasis.
Described Flos Chrysanthemi: nature and flavor are sweet, micro-hardship.Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.Be used for having a headache dizzy, the swollen eye of conjunctival congestion, blurred vision flower., main component is volatile oil, flavonoid, triterpenes and aminoacid, trace element etc., has antiviral, defying age, antiinflammatory, antineoplastic action, and cardiovascular disease is also had certain effect.
Described Fructus Lycii, sweet in the mouth; Property is put down, and returns Liver Channel; Kidney channel; Lung meridian.Fructus Lycii can the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.And the lycium barbarum polysaccharide in Fructus Lycii has certain oxidation resistance.
Described Fructus Mume, nature and flavor acid, flat, enters liver, spleen, lung, large intestine channel.Have astringe the lung, astringing intestine to stop diarrhea, promote the production of body fluid, effect of relieving colic caused by ascaris.。Include rich in protein, fat, carbohydrate, inorganic salt, vitamin C, calcium, phosphorus, ferrum, potassium etc., also be rich in the compositions such as malic acid, citric acid, succinic acid, citric acid, nutritive value is higher, there is significant antibacterial action, dysentery bacterium, bacillus pyocyaneus, Bacillus typhi, escherichia coli, tubercule bacillus, Bacillus proteus, staphylococcus aureus, vibrio cholera and various dermatophytess etc. are all had to inhibitory action.
Beneficial effect of the present invention: in sobering-up composition of the present invention, Semen Hoveniae (Fructus Hoveniae), Flos puerariae lobatae, Poria are monarch drug, Flos puerariae lobatae and Semen Hoveniae (Fructus Hoveniae) are combined use can obviously strengthen the antialcoholism action of Flos puerariae lobatae, improve L-AD (alcoholdehydrogenase, ADH) activity, its antialcoholism action is relevant with the biotransformation that strengthens ethanol.The collaborative antialcoholism action of performance, all can bring into play antialcoholism action to acute and chronic alcoholism.In addition, all there is lipoid peroxidization resistant, can have preventive and therapeutic effect to hepatic injury, hepatic fibrosis and liver cirrhosis.Add the synergism of Rhizoma Imperatae, antialcoholism action is strengthened, performance functions of strengthening stomach and promoting digestion, to alleviate the intestines and stomach burden that in the process of drinking, surfeit delicious food causes; And Radix Puerariae, Poria synergism can strengthen the intestines and stomach open up and down entire function; The improving eyesight of Flos Chrysanthemi hepatoprotective, heat-clearing and toxic substances removing, can solution asthenic fire after drinking.Fructus Mume sour in the mouth, promoting the production of body fluid to quench thirst, the diabetes involving middle-JIAO of waking up eat the merit of relieving the effect of alcohol, and except the drunk vomiting causing, plays the effect of diuresis heat clearing away, the effects such as the excretion of the materials such as the interior ethanol of acceleration bodies with Folium Nelumbinis and Flos Chrysanthemi synergism etc.
Chinese medicine composition of the present invention contains several amino acids, vegetable protein, vitamins and other nutritious components, has the wine of curing the wound heating excessive thirst, anorexia, and vomiting acid regurgitation, spits blood, discharging fresh blood stool.Disappear wine, control that dizziness, the loathing of cold, high fever, relieving acute alcoholism and recuperating the spleen, wine dysentery, diet are not thought, chest and diaphragm is glutted, send out oh, vomit sour expectorant, alcoholism injures one's stomach, spitting blood, the heat that disappears, control the effect such as discharging fresh blood stool, lung heat clearing.Its effective ingredient rapid catabolism ethanol in vivo; promote the function of liver detoxification, renal excretion; play relieving alcoholic intoxication, cephalocathartic, anti-intoxication effect, there is blood circulation promoting and blood stasis dispelling, vessel softening, enhancing blood vessel flow simultaneously, promote cardiovascular and cerebrovascular vessel blood circulation, blood supply in brain deficiency and heart myocardial ischemia are had to protective effect.Chinese medicine composition of the present invention takes full advantage of China's traditional Chinese medicine theory, adopt the Nature medicinal and edible Chinese medicine completely, it is real green natural Chinese medicine composition, wherein contain polysaccharide, flavonoid, glycoside and terpenoid, there is the immunocompetence of raising, anti peroxidation of lipid, antitumor, the anti-ageing biological function of waiting for a long time.
Experimental result of the present invention shows: before drinking, gavage can be postponed the extinction time of mice righting reflex, and gavage can shorten mice righting reflex recovery time after drink.The present invention carries out dialectical opinion to control under Chinese medical theory instructs, and for the etiology and pathogenesis of patient's insobriety, damage internal organs, takes corresponding method for the treatment of, pass through compatibility, integrated use circulation of qi promoting, diuretic, tonify deficiency, protect stomach, the method side of the determining medicine such as be amusing, regulate function, and play antialcoholism action.This effect of relieving the effect of alcohol than simple solution wine product is better, and has special effect for the chronic poisoning disease of the long-term excessive consumption of alcohol for the treatment of, and disposable oral various dose this product has the effect of obvious prophylaxis of acute alcoholism.Though in mice autonomic activities experiment, we see the present invention and can not resist ethanol completely and cause maincenter process of inhibition, are suitably postponing and are finishing in advance to have certain effect aspect this maincenter process of inhibition.
The specific embodiment
The present embodiment chemical liver is had to the Chinese medicine composition of protective effect, composition material comprises following component by mass percentage: Flos puerariae lobatae 5.93-14.81%, Semen Hoveniae (Fructus Hoveniae) 7.41-18.52%, Fructus Crataegi 7.41-18.52%, Poria 7.41-22.22%, Rhizoma Imperatae 7.41-22.22%, Folium Nelumbinis 5.93-14.81%, Flos Chrysanthemi 7.41-18.52%, Fructus Lycii 7.41-18.52%, Fructus Mume 7.41-18.52%;
In the present embodiment, said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7-14.81%, Semen Hoveniae (Fructus Hoveniae) 10-18.52%, Fructus Crataegi 10-18.52%, Poria 15-22.22%, Rhizoma Imperatae 15-22.22%, Folium Nelumbinis 7.41-14.81%, Flos Chrysanthemi 7.41-15.52%, Fructus Lycii 7.41-15.48%, Fructus Mume 7.41-15%;
In the present embodiment, composition material comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%;
In the present embodiment, said composition can add one or more for improving or treat the Chinese medicine of accompanied symptoms while use;
In the present embodiment, said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation:
Comprise raw material can be obtained to extracting solution after selected, clean rear decoction, filtration respectively, further dilution forms oral liquid;
Comprise the extracting solution obtaining is further processed into granule;
Comprise the extracting solution obtaining is further processed into capsule;
Comprise the extracting solution obtaining is further processed into buccal tablet etc.
The present invention also discloses a kind of application that chemical liver is had to the Chinese medicine composition of protective effect, and said composition has chemical liver in the Chinese medicine of protective effect and applies in preparation.
The invention will be further described in conjunction with the embodiments for lower mask body.
Embodiment mono-
The composition material of the present embodiment comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%.
When preparation, first raw material is carried out selected, clean after decoction filtering dilution can obtain oral liquid.Also can add one or more for improving or treat the Chinese medicine of accompanied symptoms.
Embodiment bis-
The composition material of the present embodiment comprises following component by mass percentage: Flos puerariae lobatae 5.93%, Semen Hoveniae (Fructus Hoveniae) 7.41%, Fructus Crataegi 7.41%, Poria 7.41%, Rhizoma Imperatae 7.41%, Folium Nelumbinis 8.87%, Flos Chrysanthemi 18.52%, Fructus Lycii 18.52%, Fructus Mume 18.52%;
When preparation, first raw material is carried out selected, clean after decoction filtering, concentrated, add adjuvant (as flavoring agent etc.) after dry and get final product granulation.
Embodiment tri-
The present embodiment chemical liver is had to the Chinese medicine composition of protective effect, composition material comprises following component by mass percentage: Flos puerariae lobatae 14.81%, Semen Hoveniae (Fructus Hoveniae) 16.52%, Fructus Crataegi 7.41%, Poria 7.41%, Rhizoma Imperatae 22.22%, Folium Nelumbinis 7.58%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.97%, Fructus Mume 8.67%.
When preparation, first raw material is carried out to selected, the rear decoction filtering of cleaning, concentrated, after being dried, add adjuvant and get final product granulation, the encapsulated capsule that obtains.
Embodiment tetra-
The composition material of the present embodiment comprises following component by mass percentage: Flos puerariae lobatae 14.81%, Semen Hoveniae (Fructus Hoveniae) 10%, Fructus Crataegi 10%, Poria 15%, Rhizoma Imperatae 15%, Folium Nelumbinis 8%, Flos Chrysanthemi 12.52%, Fructus Lycii 7.17%, Fructus Mume 7.50%.
When preparation, first raw material is carried out to selected, the rear decoction filtering of cleaning, concentrated, after being dried, add adjuvant and get final product granulation, tabletting obtains buccal tablet.
Embodiment five
Said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7%, Semen Hoveniae (Fructus Hoveniae) 10%, Fructus Crataegi 10%, Poria 15%, Rhizoma Imperatae 15%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 12.15%, Fructus Lycii 12.11%, Fructus Mume 11.33%.
In the present embodiment, said composition can add one or more for improving or treat the Chinese medicine of accompanied symptoms while use.
In the present embodiment, said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation.
Further set forth below the effect of medicine of the present invention by test example:
Test example one (clinical typical case)
1, open XX female and within 26 years old, suffer from fatty liver 3 years, glutamate pyruvate transaminase recurrent fluctuations is in 100u left and right, repeatly through Chinese and western medical treatment, unsatisfactory curative effect.By only taking the compositions that the present embodiment one makes, after one month, sb.'s illness took a favorable turn, and transaminase is normal, and clinical symptom disappearance after three months, regains one's strength, and can normally work.With nothing recurrence in anti-3 years.
2, Lee X man 38 years old is because dinner party is on the drink, often feel after drinking headache, inappetence, weak, feel sick, vomit, lose weight, upper right abdomen dull pain.Be alcoholic liver on inspection.After the rear Chinese medicine composition two weeks that takes the present embodiment four, situation is clearly better, head not bitterly, appetite increase, health energetically, without generations such as nausea and vomiting.
Test example two (zoopery)
Show by following experiment: before drinking, gavage can be postponed the extinction time of mice righting reflex, gavage can shorten mice righting reflex recovery time after drink.
Test method:
1, materials and methods:
1.1 experiment materials:
2.3.1 drunk prophylactic tria
Mice is divided into matched group, the basic, normal, high dosage group of trifoliate orange Puerariae granule, 10 every group at random.Water 12h is can't help in the first fasting of each group mice, and basic, normal, high dosage group is pressed respectively 8gkg
-1, 16gkg
-1, 32gkg
-1gavage, matched group gavages equivalent distilled water, and after 30min, each group mice is all by 18mLkg
-156 ° of strong, colourless liquor distilled from sorghum of gavage, record mice righting reflex loss to righting reflex and recover the required time.The results are shown in Table 1.
2.3.2 drunk therapeutic test
Mice is divided into matched group, the basic, normal, high dosage group of compositions of the present invention at random, and 10 every group, fasting be can't help after water 12h, first fills with wine 18mLkg for each group
-1body weight, after 15min, basic, normal, high dosage group is pressed respectively 8gkg
-1, 16gkg
-1, 32gkg
-1gavage, matched group gavages equivalent distilled water.Observe and record mouse sleep time and drunk number of animals (take righting reflex as index), record recovers the required time to mice righting reflex loss to righting reflex after drinking.Drunk prevention and treatment experimental result are in table 1.
The each group of table 1 mice righting reflex loss is to recovering required time (n=10)
* p<0.05 compared with matched group
Drunk result of the test shows: the shortening mice righting reflex loss that the high, medium and low dosage of trifoliate orange Puerariae granule can be is in various degree to the time of recovering, and showing has a certain therapeutical effect of prevention to acute ethanol is poisoning.
2.3.3 the compositions of the present invention impact poisoning on mice acute ethanol
Mice is divided into high, medium and low dosage group and model control group at random, gives respectively tested material 32gkg
-1, 16gkg
-1, 8gkg
-1and distilled water gavage.After 30min, high, medium and low dosage group, 56 ° of strong, colourless liquor distilled from sorghum for matched group, with 20mLkg
-1gavage, matched group is to distilled water, and Continuous Observation 7d, records each group of dead mouse number.The results are shown in Table 2.
The impact that table 2 compositions of the present invention is poisoning on mice acute ethanol
* p<0.05 compared with matched group
Result shows: the high, medium and low dosage of compositions of the present invention can reduce chmice acute alcoholism death toll in various degree.
2.3.4 mice autonomic activities experiment
Mice is divided into high, medium and low dosage group, model control group at random, gives respectively tested material 32gkg
-1, 16gkg
-1, 8gkg
-1and distilled water gavage.Give after tested material 30min, all animals with 56 ° of strong, colourless liquor distilled from sorghum with 10mLkg
-1gavage, puts into empty van in 20min by animal, puts one at every turn, adapt to, after 1min, record the movable number of times of 5min, and as autonomic activities index, more high, medium and low dosage group and model control group autonomic activities number of times.The results are shown in Table 3.
Table 3 compositions of the present invention causes the impact (n=10) of mice autonomic activities
* p<0.05 compared with model control group
Experimental result shows, after model control group mice ethanol gavage 20min, in 5min, autonomic activities significantly reduces, high dose group and middle dosage group are gavaging after ethanol 20min, independent activity of animals all significantly increases compared with model control group, illustrates that the maincenter that disposable oral compositions of the present invention causes alcohol in high concentration suppresses to have certain mitigation.
2.3.5 climb net experiment
Mice is divided into high, medium and low dosage group, matched group at random, and before experiment, water 12h is can't help in fasting.Give respectively tested mice 32gkg
-1, 16gkg
-1, 8gkg
-1and distilled water, after 30min, all use 56 ° of strong, colourless liquor distilled from sorghum 0.10mL10g for each group
-1body weight gavages, and then immediately mice is placed on vertical on the net, observes mice active situation.It is longer than control group mice that the high, medium and low dosage group of result mice climbs the net time.
3. results and analysis
The test of relieving the effect of alcohol shows: high, medium and low dosage makes acute alcoholism control mice mortality rate be reduced to respectively 5.0%, 30.0%, 45.0% from 80.0%; Cause maincenter process of inhibition though can not resist ethanol completely in mice autonomic activities experiment demonstration compositions of the present invention, suitably postponing and finishing in advance to there is certain effect aspect this maincenter process of inhibition.Mechanism to compositions effect of the present invention and ethanol chronic poisoning is caused to the repair of visceral organ injury further studies.
Claims (6)
1. a Chinese medicine composition that chemical liver is had to protective effect, is characterized in that: said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 5.93-14.81%, Semen Hoveniae (Fructus Hoveniae) 7.41-18.52%, Fructus Crataegi 7.41-18.52%, Poria 7.41-22.22%, Rhizoma Imperatae 7.41-22.22%, Folium Nelumbinis 5.93-14.81%, Flos Chrysanthemi 7.41-18.52%, Fructus Lycii 7.41-18.52%, Fructus Mume 7.41-18.52%.
2. the Chinese medicine composition that chemical liver is had to protective effect according to claim 1, is characterized in that: said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7-14.81%, Semen Hoveniae (Fructus Hoveniae) 10-18.52%, Fructus Crataegi 10-18.52%, Poria 15-22.22%, Rhizoma Imperatae 15-22.22%, Folium Nelumbinis 7.41-14.81%, Flos Chrysanthemi 7.41-15.52%, Fructus Lycii 7.41-15.48%, Fructus Mume 7.41-15%.
3. the Chinese medicine composition that chemical liver is had to protective effect according to claim 2, is characterized in that: composition material comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%.
4. according to chemical liver being had to the Chinese medicine composition of protective effect described in the arbitrary claim of claims 1 to 3, it is characterized in that: said composition can add one or more for improving or treat the Chinese medicine of accompanied symptoms while use.
5. according to chemical liver being had to the Chinese medicine composition of protective effect described in the arbitrary claim of claims 1 to 3, it is characterized in that: said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation.
6. described in the arbitrary claim of claims 1 to 3, chemical liver is had to the application of the Chinese medicine composition of protective effect, it is characterized in that: said composition is applied in preparation has the Chinese medicine of protective effect to chemical liver.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410111029.7A CN103860937A (en) | 2014-03-24 | 2014-03-24 | Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410111029.7A CN103860937A (en) | 2014-03-24 | 2014-03-24 | Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103860937A true CN103860937A (en) | 2014-06-18 |
Family
ID=50900324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410111029.7A Pending CN103860937A (en) | 2014-03-24 | 2014-03-24 | Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103860937A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105560475A (en) * | 2015-12-21 | 2016-05-11 | 新疆环拓生物科技有限公司 | Traditional Chinese medicine composition for preventing chemical liver injury and preparation method thereof |
CN105770565A (en) * | 2016-04-29 | 2016-07-20 | 何蓉蓉 | Liver injury treating and in-vivo autioxidant enzyme activity enhancing composition and application thereof |
CN108434256A (en) * | 2018-05-18 | 2018-08-24 | 杨波 | A kind of removing toxic substances row's fat that nourishes the liver to improve visual acuity restores the Chinese medicine preparation of liver metabolism function |
CN109122856A (en) * | 2018-07-05 | 2019-01-04 | 乙丙丁健康产业(深圳)有限公司 | A kind of liver-protecting sober-up Chinese medicine composition |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101028083A (en) * | 2007-04-16 | 2007-09-05 | 北京艺信堂医药研究所 | Health-care food with liver-protecting function |
CN101972462A (en) * | 2010-10-21 | 2011-02-16 | 江苏颐海药业有限责任公司 | Alcohol-relieving healthcare product |
CN102422947A (en) * | 2011-11-05 | 2012-04-25 | 安徽省天旭茶业有限公司 | Multi-component lotus leaf tea beverage and preparation method thereof |
-
2014
- 2014-03-24 CN CN201410111029.7A patent/CN103860937A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101028083A (en) * | 2007-04-16 | 2007-09-05 | 北京艺信堂医药研究所 | Health-care food with liver-protecting function |
CN101972462A (en) * | 2010-10-21 | 2011-02-16 | 江苏颐海药业有限责任公司 | Alcohol-relieving healthcare product |
CN102422947A (en) * | 2011-11-05 | 2012-04-25 | 安徽省天旭茶业有限公司 | Multi-component lotus leaf tea beverage and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
陈汉阳: "中西医结合治疗高血脂症研究进展", 《现代中西医结合杂志》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105560475A (en) * | 2015-12-21 | 2016-05-11 | 新疆环拓生物科技有限公司 | Traditional Chinese medicine composition for preventing chemical liver injury and preparation method thereof |
CN105770565A (en) * | 2016-04-29 | 2016-07-20 | 何蓉蓉 | Liver injury treating and in-vivo autioxidant enzyme activity enhancing composition and application thereof |
CN108434256A (en) * | 2018-05-18 | 2018-08-24 | 杨波 | A kind of removing toxic substances row's fat that nourishes the liver to improve visual acuity restores the Chinese medicine preparation of liver metabolism function |
CN109122856A (en) * | 2018-07-05 | 2019-01-04 | 乙丙丁健康产业(深圳)有限公司 | A kind of liver-protecting sober-up Chinese medicine composition |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
CN103520578B (en) | A kind of Chinese medicine composition for the treatment of oral ulcer and preparation method thereof | |
CN103652361A (en) | Feed for postpartum sow in lactation period of 1-20 days and preparation method thereof | |
CN105166544A (en) | Pig mixed feed and preparation method thereof | |
CN104824455A (en) | Cattle formula feed and preparation method thereof | |
CN102205108A (en) | Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
CN103860937A (en) | Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine | |
CN102488847B (en) | Traditional Chinese medicine composition for treating chicken infectious bursal disease as well as preparation method and application thereof | |
CN104366123A (en) | Functional feed for preventing infectious pancreatic diseases in rainbow trouts and production method thereof | |
CN103431260A (en) | Mixed-grain full-nutrition formulation food for patients with gastrointestinal tract malabsorption and pancreatitis | |
KR20130122834A (en) | Korean herb tea composing of extract from spring onion root and method preparing thereof | |
CN105028995A (en) | Mixed dog food and preparation method thereof | |
CN103007145B (en) | Traditional Chinese medicine composition for treating children rotavirus enteritis and preparation method of composition | |
CN102266511A (en) | Chewable tablet for removing summer heat and strengthening stomach for children, and preparation method thereof | |
CN101745042B (en) | Composition with effects of relieving alcoholism and protecting liver and preparation method thereof | |
CN103301341A (en) | Traditional Chinese medicine composition of treating ischemic cerebral apoplexy | |
CN107115515A (en) | A kind of Hyperglycemic health care Chinese medicine composition and preparation method thereof | |
CN105396110A (en) | Powder used for preventing branchiomycosis of tilapia and preparation method thereof | |
CN104606571A (en) | Fresh spinach root tea substituted drink with effects of helping produce saliva and slaking thirst and preparation method thereof | |
CN103920042A (en) | Drug for treating heat invasion nutritive blood type virus meningitis, as well as preparation method thereof | |
CN103947893A (en) | Feed and traditional Chinese medicine composition for preventing and treating duck aspergillosis and preparation method of feed | |
CN103690878A (en) | Traditional Chinese medicine formula for caring and treating stomach and liver | |
CN108524861A (en) | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating insomnia | |
CN105168709A (en) | Traditional Chinese medicine composition for treating stomach distension | |
CN107137689A (en) | A kind of Chinese medicine composition for treating menopausal syndrome |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140618 |
|
RJ01 | Rejection of invention patent application after publication |