CN103860937A - Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine - Google Patents

Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine Download PDF

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Publication number
CN103860937A
CN103860937A CN201410111029.7A CN201410111029A CN103860937A CN 103860937 A CN103860937 A CN 103860937A CN 201410111029 A CN201410111029 A CN 201410111029A CN 103860937 A CN103860937 A CN 103860937A
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China
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chinese medicine
fructus
percent
composition
traditional chinese
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CN201410111029.7A
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Chinese (zh)
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冯彬彬
张建海
牛小花
杨德全
陈园园
王兴
杨俊林
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重庆三峡医药高等专科学校
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Priority to CN201410111029.7A priority Critical patent/CN103860937A/en
Publication of CN103860937A publication Critical patent/CN103860937A/en

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Abstract

The invention discloses a traditional Chinese medicine with a function of protecting chemical liver injury and an application of the traditional Chinese medicine. The medicinal/edible traditional Chinese medicine comprises the following steps in percentage by weight: 5.93-14.81 percent of flower of kudzuvine, 7.41-18.52 percent of turnjujube, 7.41-18.52 percent of hawthorn, 7.41-22.22 percent of poria cocos, 7.41-22.22 percent of lalang grass rhizome, 5.93-14.81 percent of lotus leaf, 7.41-18.52 percent of chrysanthemum, 7.41-18.52 percent of fruit of Chinese wolfberry and 7.41-18.52 percent of smoked plum. The traditional Chinese medicine has a function of protecting liver injury caused by ethyl alcohol and can reach the purposes of dispelling the effects of alcohol and nourishing liver and stomach, has the efficacies of promoting the circulation of qi, alleviating water retention, tonifying deficiency, protecting stomach and refreshing the spleen, treats both symptoms and root causes, and is safe and effective pure Chinese medicine composition preparation.

Description

Chemical liver is had to Chinese medicine composition and the application thereof of protective effect
Technical field
The present invention relates to a kind ofly for chemical liver being had to the Chinese medicine composition of protective effect, be specifically related to a kind of Chinese medicine composition and application thereof that chemical liver is had to protective effect.
Background technology
Liver is that in digestion, maximum, most important digestion body of gland have important digestive function.Liver is also the main hemopoietic organ of fetus and the main metabolic organ of human body and defence organ.It implements its powerful defence function of detoxification generally to the external many harmful factors with metabolism generation of human body, and liver has very strong biotransformation, function of detoxification to external chemical toxicant.Wherein mainly contain following four kinds of modes: 1, oxidation removing toxic substances, if ethanol is the main harmful chemicals during many people drink, in body, through ethanol hydrogen enzyme, be oxidized in turn aldehyde and acid, other alcohols, aldehydes also become acid by this mode-conversion.Acid is combined into salt with other materials, and toxicity disappears, and gets rid of external.2, reduction and detoxication.For example industrial poison Nitrobenzol, nitro on phenyl ring is reducible is amino, amino toxicity is little more than the toxicity of nitro; The Chloral that hypnosis is used is reduced to ethapon and loses syngignoscism in liver, clinically the chloromycetin of use, once the organochlorine pesticide widely applied was all also that deoxidation and reduction is realized removing toxic substances in liver.3, hydrolysis removing toxic substances.Through the effect of hydrolytic enzyme, there is hydrolyzable in many harmful chemicals, change structure loses or destruction of toxic group and disappear or alleviated toxicity in conclusion.For example in body, H2O2, free radical, lipid peroxide all can lose illeffects after dissolving.4, in conjunction with toxicity.It is the main mode of liver toxicity removing toxic substances, often in conjunction with some polar groups, form water solublity larger material, alleviate or disappeared toxicity and get rid of external, for example Organic substance and carboxyl, with sulfate radical, with xanthogen, with glucuronic acid, with glycine, combining with glutathion etc., is all the important form of liver detoxification biotransformation.When this defence harmful factor is to body damage, itself also comes to harm liver unavoidably.Chemical liver injury is the hepatic injury being caused by chemical Hepatoxic substance.These chemical substances comprise chemical toxicant and the some drugs in ethanol, environment.As the liver of the important removing toxic substances organ of human body, there is Hepatic artery and hepatic vein double blood supply.Chemical substance can enter liver by gastrointestinal tract portal vein or body circulation and transform, and therefore liver is easily subject to the toxicant infringement in chemicals.Further investigation reveals that, in recent years due to the increase of social needs and social life pressure, excessive drinking and alcoholism have become the public health problem of China, ethanol has certain toxicity to liver, kidney, gastrointestinal tract, nervous system, blood circulation, and long-term excessive drinking causes the diseases such as mental disorder, gastric ulcer and liver fat, alcoholic hepatitis, liver cirrhosis.Also there are some data to show certain cancers, as the morbidity of oral cancer, pharyngeal cancer, laryngeal carcinoma, colon cancer and upper respiratory tract cancer and excessive consumption of alcohol also have substantial connection simultaneously.Acute a large amount of drinking can cause nausea, vomiting, hypomnesis, absent minded, psychomotor abilities is impaired and emotional instability, causes accident frequency rate to increase.The serious generation that even causes acute death.From ancient times to the present, people just attempt to adopt the whole bag of tricks to remove or alleviate toxic and side effects human body being produced after drinking, and therefore and constantly various antialcoholic drugs also come out, from fruit to corn, from food to medicine, rich and varied.The form of mainly utilizing Chinese herbal medicine to make Chinese medicine composition herein reaches relieves the effect of alcohol, and the object of stomach is protected in nourishing the liver.
In prior art, Chinese patent relieves the effect of alcohol as CN03111706, CN0610070068, CN0610125432, CN0810124841, CN0510012629 etc. disclose and fills a prescription and preparation method, the disclosed medicine of above-mentioned patent or patent medicine all has certain effect, but have little effect, people are still exploring better Chinese medicine formula, to improve people's health level, really play the effect of hepatoprotective.
Summary of the invention
In view of this; object of the present invention provides a kind of Chinese medicine composition that chemical liver is had to protective effect; be applied to the protection of chemical liver; to the excessive thirst of generating heat after drinking; anorexia; vomiting acid regurgitation, spits blood, and discharging fresh blood stool and the wine that disappears, dizziness, the loathing of cold, high fever, relieving acute alcoholism and recuperating the spleen, wine dysentery, diet are not thought, chest and diaphragm is glutted, send out oh, the symptom such as lung heat clearing improves significantly.
The Chinese medicine composition that chemical liver is had to protective effect of the present invention, composition material comprises following component by mass percentage: Flos puerariae lobatae 5.93-14.81%, Semen Hoveniae (Fructus Hoveniae) 7.41-18.52%, Fructus Crataegi 7.41-18.52%, Poria 7.41-22.22%, Rhizoma Imperatae 7.41-22.22%, Folium Nelumbinis 5.93-14.81%, Flos Chrysanthemi 7.41-18.52%, Fructus Lycii 7.41-18.52%, Fructus Mume 7.41-18.52%;
Further, said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7-14.81%, Semen Hoveniae (Fructus Hoveniae) 10-18.52%, Fructus Crataegi 10-18.52%, Poria 15-22.22%, Rhizoma Imperatae 15-22.22%, Folium Nelumbinis 7.41-14.81%, Flos Chrysanthemi 7.41-15.52%, Fructus Lycii 7.41-15.48%, Fructus Mume 7.41-15%;
Further, composition material comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%;
Further, when said composition is used, can add one or more for improving or treat the Chinese medicine of accompanied symptoms;
Further, said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation,
Comprise raw material can be obtained to extracting solution after selected, clean rear decoction, filtration respectively, further dilution forms oral liquid;
Comprise the extracting solution obtaining is further processed into granule;
Comprise the extracting solution obtaining is further processed into capsule;
Comprise the extracting solution obtaining is further processed into buccal tablet etc.
The present invention also discloses a kind of application that chemical liver is had to the Chinese medicine composition of protective effect, and said composition has chemical liver in the Chinese medicine of protective effect and applies in preparation.
Flos puerariae lobatae, nature and flavor are sweet, flat, enter spleen, stomach warp, have effect of relieving acute alcoholism and recuperating the spleen, are applicable to glutted swollen, the anorexia of insobriety, headache, dizziness, excessive thirst, breast belch, acid regurgitation, are the most representative antialcoholic drugs in traditional medicine.
Semen Hoveniae (Fructus Hoveniae), property is flat, sweet in the mouth.Enter through heart channel, spleen channel, have the relieving restlessness of quenching the thirst, disappear damp and hot, alcoholic intoxication.Be mainly used in middle alcoholism, excessive thirst vomiting, difficulty in urination and defecation; its energy accelerating alcohol metabolism; strengthen alcohol dehydrogenase activity; shorten the relieving alcoholic intoxication time; suppress alcohol induced flesh pine effect (the flavanone I of getting from Semen Hoveniae (Fructus Hoveniae); II; III (hovenitins I; II; III) alcohol induced flesh pine effect is had to inhibitory action); cholesterol, glycerol trioleate due to can Anti-ethanol increase, and to hepatic lipid peroxidation tool protective effect due to ethanol, may delay and prevent that the fatty liver due to ethanol from forming.
Described Fructus Crataegi, nature and flavor acid, sweet, tepor, returns spleen, stomach, Liver Channel, has promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis, can reduce the cholesterol level in blood and lipid is reduced in intraorganic deposition, has certain sober-up function.Secretion that can facilitating digestion enzyme, Fructus Crataegi is containing vitamin C, vitamin B2, carotene and multiple organic acid, the oral secretion that can increase digestive enzyme in stomach, and can strengthen the activity of enzyme, facilitating digestion, wherein contained lipase can directly help digest fat food, and can strengthen the activity of gastric lipase, protease.Fructus Crataegi has obvious Accommodation to gastrointestinal dysfunction, reaches strengthening the spleen to promote digestion effect.
Described Poria, property slightly sweet flavor is flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Poria cocos sclerotium is containing effective ingredient such as triterpenes and polysaccharide.
Described Rhizoma Imperatae, nature and flavor are sweet, cold, enter lung, stomach, urinary bladder channel.There is effect of cooling blood for hemostasis, clearing away heat and promoting diuresis.Cure mainly lung-heat dyspnea with rapid respiration, edema, jaundice and alcohol intoxication, can alcoholic intoxication.
Described Folium Nelumbinis bitter in the mouth is pungent micro-puckery, cool in nature, GUIXIN, liver, spleen channel, and delicate fragrance rises loose; There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, effect of dissipating blood stasis hemostasis.
Described Flos Chrysanthemi: nature and flavor are sweet, micro-hardship.Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.Be used for having a headache dizzy, the swollen eye of conjunctival congestion, blurred vision flower., main component is volatile oil, flavonoid, triterpenes and aminoacid, trace element etc., has antiviral, defying age, antiinflammatory, antineoplastic action, and cardiovascular disease is also had certain effect.
Described Fructus Lycii, sweet in the mouth; Property is put down, and returns Liver Channel; Kidney channel; Lung meridian.Fructus Lycii can the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.And the lycium barbarum polysaccharide in Fructus Lycii has certain oxidation resistance.
Described Fructus Mume, nature and flavor acid, flat, enters liver, spleen, lung, large intestine channel.Have astringe the lung, astringing intestine to stop diarrhea, promote the production of body fluid, effect of relieving colic caused by ascaris.。Include rich in protein, fat, carbohydrate, inorganic salt, vitamin C, calcium, phosphorus, ferrum, potassium etc., also be rich in the compositions such as malic acid, citric acid, succinic acid, citric acid, nutritive value is higher, there is significant antibacterial action, dysentery bacterium, bacillus pyocyaneus, Bacillus typhi, escherichia coli, tubercule bacillus, Bacillus proteus, staphylococcus aureus, vibrio cholera and various dermatophytess etc. are all had to inhibitory action.
Beneficial effect of the present invention: in sobering-up composition of the present invention, Semen Hoveniae (Fructus Hoveniae), Flos puerariae lobatae, Poria are monarch drug, Flos puerariae lobatae and Semen Hoveniae (Fructus Hoveniae) are combined use can obviously strengthen the antialcoholism action of Flos puerariae lobatae, improve L-AD (alcoholdehydrogenase, ADH) activity, its antialcoholism action is relevant with the biotransformation that strengthens ethanol.The collaborative antialcoholism action of performance, all can bring into play antialcoholism action to acute and chronic alcoholism.In addition, all there is lipoid peroxidization resistant, can have preventive and therapeutic effect to hepatic injury, hepatic fibrosis and liver cirrhosis.Add the synergism of Rhizoma Imperatae, antialcoholism action is strengthened, performance functions of strengthening stomach and promoting digestion, to alleviate the intestines and stomach burden that in the process of drinking, surfeit delicious food causes; And Radix Puerariae, Poria synergism can strengthen the intestines and stomach open up and down entire function; The improving eyesight of Flos Chrysanthemi hepatoprotective, heat-clearing and toxic substances removing, can solution asthenic fire after drinking.Fructus Mume sour in the mouth, promoting the production of body fluid to quench thirst, the diabetes involving middle-JIAO of waking up eat the merit of relieving the effect of alcohol, and except the drunk vomiting causing, plays the effect of diuresis heat clearing away, the effects such as the excretion of the materials such as the interior ethanol of acceleration bodies with Folium Nelumbinis and Flos Chrysanthemi synergism etc.
Chinese medicine composition of the present invention contains several amino acids, vegetable protein, vitamins and other nutritious components, has the wine of curing the wound heating excessive thirst, anorexia, and vomiting acid regurgitation, spits blood, discharging fresh blood stool.Disappear wine, control that dizziness, the loathing of cold, high fever, relieving acute alcoholism and recuperating the spleen, wine dysentery, diet are not thought, chest and diaphragm is glutted, send out oh, vomit sour expectorant, alcoholism injures one's stomach, spitting blood, the heat that disappears, control the effect such as discharging fresh blood stool, lung heat clearing.Its effective ingredient rapid catabolism ethanol in vivo; promote the function of liver detoxification, renal excretion; play relieving alcoholic intoxication, cephalocathartic, anti-intoxication effect, there is blood circulation promoting and blood stasis dispelling, vessel softening, enhancing blood vessel flow simultaneously, promote cardiovascular and cerebrovascular vessel blood circulation, blood supply in brain deficiency and heart myocardial ischemia are had to protective effect.Chinese medicine composition of the present invention takes full advantage of China's traditional Chinese medicine theory, adopt the Nature medicinal and edible Chinese medicine completely, it is real green natural Chinese medicine composition, wherein contain polysaccharide, flavonoid, glycoside and terpenoid, there is the immunocompetence of raising, anti peroxidation of lipid, antitumor, the anti-ageing biological function of waiting for a long time.
Experimental result of the present invention shows: before drinking, gavage can be postponed the extinction time of mice righting reflex, and gavage can shorten mice righting reflex recovery time after drink.The present invention carries out dialectical opinion to control under Chinese medical theory instructs, and for the etiology and pathogenesis of patient's insobriety, damage internal organs, takes corresponding method for the treatment of, pass through compatibility, integrated use circulation of qi promoting, diuretic, tonify deficiency, protect stomach, the method side of the determining medicine such as be amusing, regulate function, and play antialcoholism action.This effect of relieving the effect of alcohol than simple solution wine product is better, and has special effect for the chronic poisoning disease of the long-term excessive consumption of alcohol for the treatment of, and disposable oral various dose this product has the effect of obvious prophylaxis of acute alcoholism.Though in mice autonomic activities experiment, we see the present invention and can not resist ethanol completely and cause maincenter process of inhibition, are suitably postponing and are finishing in advance to have certain effect aspect this maincenter process of inhibition.
The specific embodiment
The present embodiment chemical liver is had to the Chinese medicine composition of protective effect, composition material comprises following component by mass percentage: Flos puerariae lobatae 5.93-14.81%, Semen Hoveniae (Fructus Hoveniae) 7.41-18.52%, Fructus Crataegi 7.41-18.52%, Poria 7.41-22.22%, Rhizoma Imperatae 7.41-22.22%, Folium Nelumbinis 5.93-14.81%, Flos Chrysanthemi 7.41-18.52%, Fructus Lycii 7.41-18.52%, Fructus Mume 7.41-18.52%;
In the present embodiment, said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7-14.81%, Semen Hoveniae (Fructus Hoveniae) 10-18.52%, Fructus Crataegi 10-18.52%, Poria 15-22.22%, Rhizoma Imperatae 15-22.22%, Folium Nelumbinis 7.41-14.81%, Flos Chrysanthemi 7.41-15.52%, Fructus Lycii 7.41-15.48%, Fructus Mume 7.41-15%;
In the present embodiment, composition material comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%;
In the present embodiment, said composition can add one or more for improving or treat the Chinese medicine of accompanied symptoms while use;
In the present embodiment, said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation:
Comprise raw material can be obtained to extracting solution after selected, clean rear decoction, filtration respectively, further dilution forms oral liquid;
Comprise the extracting solution obtaining is further processed into granule;
Comprise the extracting solution obtaining is further processed into capsule;
Comprise the extracting solution obtaining is further processed into buccal tablet etc.
The present invention also discloses a kind of application that chemical liver is had to the Chinese medicine composition of protective effect, and said composition has chemical liver in the Chinese medicine of protective effect and applies in preparation.
The invention will be further described in conjunction with the embodiments for lower mask body.
Embodiment mono-
The composition material of the present embodiment comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%.
When preparation, first raw material is carried out selected, clean after decoction filtering dilution can obtain oral liquid.Also can add one or more for improving or treat the Chinese medicine of accompanied symptoms.
Embodiment bis-
The composition material of the present embodiment comprises following component by mass percentage: Flos puerariae lobatae 5.93%, Semen Hoveniae (Fructus Hoveniae) 7.41%, Fructus Crataegi 7.41%, Poria 7.41%, Rhizoma Imperatae 7.41%, Folium Nelumbinis 8.87%, Flos Chrysanthemi 18.52%, Fructus Lycii 18.52%, Fructus Mume 18.52%;
When preparation, first raw material is carried out selected, clean after decoction filtering, concentrated, add adjuvant (as flavoring agent etc.) after dry and get final product granulation.
Embodiment tri-
The present embodiment chemical liver is had to the Chinese medicine composition of protective effect, composition material comprises following component by mass percentage: Flos puerariae lobatae 14.81%, Semen Hoveniae (Fructus Hoveniae) 16.52%, Fructus Crataegi 7.41%, Poria 7.41%, Rhizoma Imperatae 22.22%, Folium Nelumbinis 7.58%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.97%, Fructus Mume 8.67%.
When preparation, first raw material is carried out to selected, the rear decoction filtering of cleaning, concentrated, after being dried, add adjuvant and get final product granulation, the encapsulated capsule that obtains.
Embodiment tetra-
The composition material of the present embodiment comprises following component by mass percentage: Flos puerariae lobatae 14.81%, Semen Hoveniae (Fructus Hoveniae) 10%, Fructus Crataegi 10%, Poria 15%, Rhizoma Imperatae 15%, Folium Nelumbinis 8%, Flos Chrysanthemi 12.52%, Fructus Lycii 7.17%, Fructus Mume 7.50%.
When preparation, first raw material is carried out to selected, the rear decoction filtering of cleaning, concentrated, after being dried, add adjuvant and get final product granulation, tabletting obtains buccal tablet.
Embodiment five
Said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7%, Semen Hoveniae (Fructus Hoveniae) 10%, Fructus Crataegi 10%, Poria 15%, Rhizoma Imperatae 15%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 12.15%, Fructus Lycii 12.11%, Fructus Mume 11.33%.
In the present embodiment, said composition can add one or more for improving or treat the Chinese medicine of accompanied symptoms while use.
In the present embodiment, said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation.
Further set forth below the effect of medicine of the present invention by test example:
Test example one (clinical typical case)
1, open XX female and within 26 years old, suffer from fatty liver 3 years, glutamate pyruvate transaminase recurrent fluctuations is in 100u left and right, repeatly through Chinese and western medical treatment, unsatisfactory curative effect.By only taking the compositions that the present embodiment one makes, after one month, sb.'s illness took a favorable turn, and transaminase is normal, and clinical symptom disappearance after three months, regains one's strength, and can normally work.With nothing recurrence in anti-3 years.
2, Lee X man 38 years old is because dinner party is on the drink, often feel after drinking headache, inappetence, weak, feel sick, vomit, lose weight, upper right abdomen dull pain.Be alcoholic liver on inspection.After the rear Chinese medicine composition two weeks that takes the present embodiment four, situation is clearly better, head not bitterly, appetite increase, health energetically, without generations such as nausea and vomiting.
Test example two (zoopery)
Show by following experiment: before drinking, gavage can be postponed the extinction time of mice righting reflex, gavage can shorten mice righting reflex recovery time after drink.
Test method:
1, materials and methods:
1.1 experiment materials:
2.3.1 drunk prophylactic tria
Mice is divided into matched group, the basic, normal, high dosage group of trifoliate orange Puerariae granule, 10 every group at random.Water 12h is can't help in the first fasting of each group mice, and basic, normal, high dosage group is pressed respectively 8gkg -1, 16gkg -1, 32gkg -1gavage, matched group gavages equivalent distilled water, and after 30min, each group mice is all by 18mLkg -156 ° of strong, colourless liquor distilled from sorghum of gavage, record mice righting reflex loss to righting reflex and recover the required time.The results are shown in Table 1.
2.3.2 drunk therapeutic test
Mice is divided into matched group, the basic, normal, high dosage group of compositions of the present invention at random, and 10 every group, fasting be can't help after water 12h, first fills with wine 18mLkg for each group -1body weight, after 15min, basic, normal, high dosage group is pressed respectively 8gkg -1, 16gkg -1, 32gkg -1gavage, matched group gavages equivalent distilled water.Observe and record mouse sleep time and drunk number of animals (take righting reflex as index), record recovers the required time to mice righting reflex loss to righting reflex after drinking.Drunk prevention and treatment experimental result are in table 1.
The each group of table 1 mice righting reflex loss is to recovering required time (n=10)
* p<0.05 compared with matched group
Drunk result of the test shows: the shortening mice righting reflex loss that the high, medium and low dosage of trifoliate orange Puerariae granule can be is in various degree to the time of recovering, and showing has a certain therapeutical effect of prevention to acute ethanol is poisoning.
2.3.3 the compositions of the present invention impact poisoning on mice acute ethanol
Mice is divided into high, medium and low dosage group and model control group at random, gives respectively tested material 32gkg -1, 16gkg -1, 8gkg -1and distilled water gavage.After 30min, high, medium and low dosage group, 56 ° of strong, colourless liquor distilled from sorghum for matched group, with 20mLkg -1gavage, matched group is to distilled water, and Continuous Observation 7d, records each group of dead mouse number.The results are shown in Table 2.
The impact that table 2 compositions of the present invention is poisoning on mice acute ethanol
* p<0.05 compared with matched group
Result shows: the high, medium and low dosage of compositions of the present invention can reduce chmice acute alcoholism death toll in various degree.
2.3.4 mice autonomic activities experiment
Mice is divided into high, medium and low dosage group, model control group at random, gives respectively tested material 32gkg -1, 16gkg -1, 8gkg -1and distilled water gavage.Give after tested material 30min, all animals with 56 ° of strong, colourless liquor distilled from sorghum with 10mLkg -1gavage, puts into empty van in 20min by animal, puts one at every turn, adapt to, after 1min, record the movable number of times of 5min, and as autonomic activities index, more high, medium and low dosage group and model control group autonomic activities number of times.The results are shown in Table 3.
Table 3 compositions of the present invention causes the impact (n=10) of mice autonomic activities
* p<0.05 compared with model control group
Experimental result shows, after model control group mice ethanol gavage 20min, in 5min, autonomic activities significantly reduces, high dose group and middle dosage group are gavaging after ethanol 20min, independent activity of animals all significantly increases compared with model control group, illustrates that the maincenter that disposable oral compositions of the present invention causes alcohol in high concentration suppresses to have certain mitigation.
2.3.5 climb net experiment
Mice is divided into high, medium and low dosage group, matched group at random, and before experiment, water 12h is can't help in fasting.Give respectively tested mice 32gkg -1, 16gkg -1, 8gkg -1and distilled water, after 30min, all use 56 ° of strong, colourless liquor distilled from sorghum 0.10mL10g for each group -1body weight gavages, and then immediately mice is placed on vertical on the net, observes mice active situation.It is longer than control group mice that the high, medium and low dosage group of result mice climbs the net time.
3. results and analysis
The test of relieving the effect of alcohol shows: high, medium and low dosage makes acute alcoholism control mice mortality rate be reduced to respectively 5.0%, 30.0%, 45.0% from 80.0%; Cause maincenter process of inhibition though can not resist ethanol completely in mice autonomic activities experiment demonstration compositions of the present invention, suitably postponing and finishing in advance to there is certain effect aspect this maincenter process of inhibition.Mechanism to compositions effect of the present invention and ethanol chronic poisoning is caused to the repair of visceral organ injury further studies.

Claims (6)

1. a Chinese medicine composition that chemical liver is had to protective effect, is characterized in that: said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 5.93-14.81%, Semen Hoveniae (Fructus Hoveniae) 7.41-18.52%, Fructus Crataegi 7.41-18.52%, Poria 7.41-22.22%, Rhizoma Imperatae 7.41-22.22%, Folium Nelumbinis 5.93-14.81%, Flos Chrysanthemi 7.41-18.52%, Fructus Lycii 7.41-18.52%, Fructus Mume 7.41-18.52%.
2. the Chinese medicine composition that chemical liver is had to protective effect according to claim 1, is characterized in that: said composition raw material comprises following component by mass percentage: Flos puerariae lobatae 7-14.81%, Semen Hoveniae (Fructus Hoveniae) 10-18.52%, Fructus Crataegi 10-18.52%, Poria 15-22.22%, Rhizoma Imperatae 15-22.22%, Folium Nelumbinis 7.41-14.81%, Flos Chrysanthemi 7.41-15.52%, Fructus Lycii 7.41-15.48%, Fructus Mume 7.41-15%.
3. the Chinese medicine composition that chemical liver is had to protective effect according to claim 2, is characterized in that: composition material comprises following component by mass percentage: Flos puerariae lobatae 7.41%, Semen Hoveniae (Fructus Hoveniae) 11.11%, Fructus Crataegi 11.11%, Poria 18.81%, Rhizoma Imperatae 18.22%, Folium Nelumbinis 7.41%, Flos Chrysanthemi 7.41%, Fructus Lycii 7.41%, Fructus Mume 11.11%.
4. according to chemical liver being had to the Chinese medicine composition of protective effect described in the arbitrary claim of claims 1 to 3, it is characterized in that: said composition can add one or more for improving or treat the Chinese medicine of accompanied symptoms while use.
5. according to chemical liver being had to the Chinese medicine composition of protective effect described in the arbitrary claim of claims 1 to 3, it is characterized in that: said composition can add the carrier that can accept in medical science or bromatology or health care conduct and learning to make preparation.
6. described in the arbitrary claim of claims 1 to 3, chemical liver is had to the application of the Chinese medicine composition of protective effect, it is characterized in that: said composition is applied in preparation has the Chinese medicine of protective effect to chemical liver.
CN201410111029.7A 2014-03-24 2014-03-24 Traditional Chinese medicine with function of chemical liver injury and application of traditional Chinese medicine CN103860937A (en)

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CN105560475A (en) * 2015-12-21 2016-05-11 新疆环拓生物科技有限公司 Traditional Chinese medicine composition for preventing chemical liver injury and preparation method thereof
CN105770565A (en) * 2016-04-29 2016-07-20 何蓉蓉 Liver injury treating and in-vivo autioxidant enzyme activity enhancing composition and application thereof
CN108434256A (en) * 2018-05-18 2018-08-24 杨波 A kind of removing toxic substances row's fat that nourishes the liver to improve visual acuity restores the Chinese medicine preparation of liver metabolism function

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Publication number Priority date Publication date Assignee Title
CN105560475A (en) * 2015-12-21 2016-05-11 新疆环拓生物科技有限公司 Traditional Chinese medicine composition for preventing chemical liver injury and preparation method thereof
CN105770565A (en) * 2016-04-29 2016-07-20 何蓉蓉 Liver injury treating and in-vivo autioxidant enzyme activity enhancing composition and application thereof
CN108434256A (en) * 2018-05-18 2018-08-24 杨波 A kind of removing toxic substances row's fat that nourishes the liver to improve visual acuity restores the Chinese medicine preparation of liver metabolism function

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