CN104189445A - Traditional Chinese medicine composition and preparation method and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition and a preparation method and application thereof. The active ingredients of the traditional Chinese medicine composition consist of the following components in parts by weight: 10-30 parts of radix rehmanniae recen, 7-25 parts of prepared rehmannia root, 10-30 parts of the fruit of Chinese wolfberry, 8-20 parts of dogwood, 12-35 parts of Chinese yam, 5-20 parts of moutan bark, 5-18 parts of rhizoma alismatis, 10-30 parts of poria cocos, 4-10 parts of liquorice, 7-18 parts of radix scrophulariae, 10-30 parts of tuber of dwarf lilyturf, 10-20 parts of radix paeoniae alba and 2-20 parts of chrysanthemum. The traditional Chinese medicine with the components can be prepared into decoction, tablets, capsules, granules or syrups, the preparation method is simple, and when the traditional Chinese medicine with the components is taken, the lacrimal secretion can be improved, the lacrimal film is stabilized, and the dry eye symptom is further improved. In addition, the traditional Chinese medicine is readily available in raw materials, is simple in preparation method, is non-toxic and pollution-free, and does not have drug resistance.

Description

A kind of Chinese medicine composition and its preparation method and application

 

Technical field

The present invention relates to a kind of Chinese medicine composition, concrete is a kind of Chinese medicine composition for alleviating dry eye symptom and its production and use.

Background technology

Xerophthalmia is the unstable and/or ocular surface injury of the tear film that extremely causes due to the amount of tear or matter or hydrodynamics, thereby causes a class disease of a malaise symptoms and visual disorder.All kinds of xerophthalmia, xerophthalmia and the dry eye syndromes etc. of the clinical appearance of China are the unified xerophthalmia that is called all.Xerophthalmia common sympton has eye sensation of dryness, burn feeling, foreign body sensation, prickling sensation, ophthalmic pruritus, photophobia, furious, blurred vision, vision fluctuation etc.

Xerophthalmia has become affects people's common eye surface diseases of a class of quality of life.In world wide, dry eye morbidity rate is greatly about 5.5% ~ 33.7% at present, and wherein women is higher than male, and old people is higher than adolescence, and Aisan is higher than other ethnic groups.According to the existing epidemiological study of China, show, xerophthalmia at the sickness rate of China about 21% ~ 30%.Its risk factor mainly contains old-age group, women, high height above sea level, diabetes, pterygium, air pollution, collyrium abuse, uses video display terminal, cornea refractive surgery, allergic ophthalmopathy and part systemic disease etc.

Xerophthalmia is divided into 5 types: 1, water liquid shortage type xerophthalmia: water fluidity tear generates the abnormal of deficiency and/or matter and causes, the xerophthalmia causing as dry syndrome and many general factors; 2, evaporated strong type xerophthalmia: because the abnormal of lipid layer matter or amount causes, as meibomian gland dysfunction, video display terminal syndrome etc. causes evaporation, increase; 3, mucoprotein shortage type xerophthalmia: be impaired the causing of eye table epithelial cell, if drug toxicity, chemical injury, thermal burn are to infringement of eye table etc.; 4, tear kinetics ectype xerophthalmia: the kinetics by tear causes extremely, as abnormal, the tear of twinkling is discharged and is delayed etc.; 5, mixed type xerophthalmia: being modal xerophthalmia type clinically, is the above caused xerophthalmia of two or more reason.

Domestic employing xerophthalmia noun standard refers to that patient has the symptom of xerophthalmia but without the various sign situations of xerophthalmia, especially without ocular surface injury, do not cause part or the constitutional cause of xerophthalmia.Occur that above-mentioned symptom may be momentary reason, as reading or computer cause once in a while ophthalmic uncomfortable but as long as through rest or of short duration by artificial tear, can recover normal.Yet the principal element that causes xerophthalmia is as follows: lacrimal secretion deficiency or lacrimal secretion function are improper, the class vapo(u)rability xerophthalmia too much causing as lost due to tear.For the parafunctional situation of the latter's lacrimal secretion, be likely that lachrymal gland is not enough, as constitutional oligodacrya is called again congenital alacrima, this may be there is no lachrymal gland or have lachrymal gland, but lacks secretion; Another kind of is Secondary cases oligodacrya as situation about occurring after vitamin A deficiency, lymphoma, sarcoidosis, HIV (human immunodeficiency virus) infection and large portion dacryoadenectomy.

In life, we usually take some preventive measures to avoid causing the situation of xerophthalmia, wherein notice that eyes moisturizing is the best preventive method.Note, by a custom, regularly having a rest, the time before computer screen should not be long continuously, every 1 hour, will have a rest 5 ~ 10 minutes, when space, lookes far into the distance and allow eyes loosen.As worked in air conditioner surroundings for a long time or driving night, should actively improve work and living environment, stop using in time long-term whole body or topical application can cause medicine and the eye cosmetic of xerophthalmia.For meibomian gland dysfunction patient should carry out that eyelid is clean, hot compress and tarsal glands massage.Note diet structure, many vitimin supplement A, C, D, eat Radix Dauci Sativae, fruit, marine product etc. more simultaneously.

Also cannot effect a radical cure clinical middle discovery eyes are dry and astringent at present, adopt the artificial tears can relief of symptoms; Once but to stop using, symptom can recur again.Artificial tears's composition can keep eye table moistening, alleviating dry eye symptom, but can not solve root problem.Drip with eye drop simultaneously and also have some potential hazards, eye drop is high to personal cleanliness and hygienic requirements, not so there will be the phenomenon of infection, and in collyrium, antiseptic also may make the Conjunctival Goblet Cells in eye corneal epithelium cell and eyes damage.

Summary of the invention

The invention provides that a kind of cost is low, taking convenience, good effect be for the Chinese medicine composition of xerophthalmia, it is mainly realized by the following technical programs.

Chinese medicine composition of the present invention is comprised of the component of following weight portion: 2 ~ 20 parts of 10 ~ 20 parts of 10 ~ 30 parts of Radix Rehmanniae, 7 ~ 25 parts of Radix Rehmanniae Preparata, 10 ~ 30 parts of Fructus Lycii, 8 ~ 20 parts of Fructus Corni, 12 ~ 35 parts of Rhizoma Dioscoreaes, 5 ~ 20 parts of Cortex Moutans, 5 ~ 18 parts of Rhizoma Alismatis, 10 ~ 30 parts, Poria, 4 ~ 10 parts, Radix Glycyrrhizae, 7 ~ 18 parts of Radix Scrophulariaes, 10 ~ 30 parts of Radix Ophiopogonis, the Radix Paeoniae Alba and Flos Chrysanthemis.

Chinese medicine composition of the present invention is comprised of the component of following weight portion: 6 ~ 15 parts of 12 ~ 15 parts of 15 ~ 25 parts of Radix Rehmanniae, 12 ~ 20 parts of Radix Rehmanniae Preparata, 15 ~ 25 parts of Fructus Lycii, 12 ~ 15 parts of Fructus Corni, 18 ~ 25 parts of Rhizoma Dioscoreaes, 10 ~ 15 parts of Cortex Moutans, 9 ~ 12 parts of Rhizoma Alismatis, 15 ~ 27 parts, Poria, 6 ~ 8 parts, Radix Glycyrrhizae, 10 ~ 12 parts of Radix Scrophulariaes, 20 ~ 25 parts of Radix Ophiopogonis, the Radix Paeoniae Alba and Flos Chrysanthemis.

Chinese medicine compositions of the present invention is comprised of the component of following weight portion: 6 parts of 20 parts of Radix Rehmanniae, 15 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Lycii, 12 parts of Fructus Corni, 20 parts of Rhizoma Dioscoreaes, 10 parts of Cortex Moutans, 9 parts of Rhizoma Alismatis, 20 parts, Poria, 6 parts, Radix Glycyrrhizae, 10 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 15 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Particularly, above-mentioned Radix Rehmanniae, i.e. Radix Rehmanniae, another name: the Radix Rehmanniae, marrow, Proterozoic, dry Radix Rehmanniae, benzyl, glutinous rehmannia, Fructus Elaeagni Umbellatae, grandmother's milk, Latin is called Rehmanniaglutinosa, is Scrophulariaceae, Radix Rehmanniae platymiscium, the tuber of Radix Rehmanniae, perennial vertical herbage, is heat removing and blood cooling medicine.Its property of medicine: sweet, bitter, cold; GUIXIN, liver, kidney channel.Function cures mainly: clearing away heat and cooling blood, promote the production of body fluid and moisturize.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 3611-3613 page page)

Particularly, above-mentioned Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata, belongs to Scrophulariaceae, Radix Rehmanniae platymiscium, Radix Rehmanniae (Rehmanniaglutinosa(Gdertn) Iibosch.exFisch.etMey.) tuber through processing, concoct and form.Modern medical theory research, the contained Dihuang polysaccharide of Radix Rehmanniae Preparata has obvious immune antitumor activity, also has significant heart tonifying, diuresis, protects the liver, the effect such as blood sugar lowering, anti-hypertrophy, exudation, antiinflammatory, antifungal, anti-radiation.Its property of medicine: sweet, warm, return liver, kidney channel.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 3703-3704 page)

Particularly, the different name of above-mentioned Fructus Lycii is the red reality of Fructus Lycii, Radix Betae, and FRUCTUS LYCII BARBARI, Canis familiaris L. milk, dark purple green pepper, Pedis Canitis, FRUCTUS LYCII, ground frame, real is the fruit of Solanaceae Lycium plant lycium barbarum.The property of medicine: sweet, flat, return liver, kidney, lung meridian.Function cures mainly: nourishing the liver, YIN nourishing, lung moistening.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 2247-2249 page)

Particularly, the formal name used at school of above-mentioned Fructus Corni: CornusofficinalisSieb.etZucc, another name Fructus Corni, Fructus Corni, mountain are in meat etc.The property of medicine: acid, be slightly cold; Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, convergence is solid de-.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 246-247 page)

Particularly, above-mentioned Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae, its different name for administration is pre-, Rhizoma Dioscoreae, Rhizoma Dioscoreae, all administrations, potato Henan, that jade prolongs, repaiies is crisp, Wang Mao, Rhizoma Dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, white sweet potato, nine Dioscorea zingiberensis, mountain plate potato, fan potato, Buddhist palm potato.The property of medicine: sweet, flat; Return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing, support lung.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 217-218 page)

Particularly, different name moutan root bark, Cortex Moutan or the DANGEN of above-mentioned Cortex Moutan.Its property of medicine is bitter, pungent, is slightly cold; GUIXIN, liver, kidney channel.There is clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 1576-1578 page)

Particularly, above-mentioned Rhizoma Alismatis different name is marshy land, Rhizoma Alismatis, grandson Yu, Saxidomus purpuratus, day bald.Its property of medicine: sweet, light, cold; Return kidney, urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, expels the heat-evil treating stranguria.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 2066-2067 page)

Particularly, the different name of above-mentioned Poria is Fu Tu or Masson Pine potato etc.Its property of medicine: sweet, light, flat; GUIXIN, spleen, lung, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 2153-2154 page)

Particularly, the another name of above-mentioned Radix Glycyrrhizae is that state is old, Herba Hedyotis cantonensis, sweet root, and Latin is called GlycyrrhizauralensisFisch, is pulse family, Glycyrrhiza perennial herb.Its property of medicine: sweet, flat; Return spleen, stomach, the heart, lung meridian.Function cures mainly: with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 788-790 page)

Particularly, above-mentioned Radix Scrophulariae is Scrophulariaceae herbaceous plant, have another name called Chong Tai, positive horse, Xuan Tai, Radix Scrophulariae, ghost hide, by horse, fougere, black ginseng, Radix Scrophulariae, mountain Radix Angelicae Sinensis.Its property of medicine: sweet, bitter, salty, be slightly cold; Return lung, stomach, kidney channel.Function cures mainly: removing heat from blood, nourishing YIN to lower pathogenic fire, removing toxic substances.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 1060-1061 page)

Particularly, above-mentioned Radix Ophiopogonis (Ophiopogonjaponicus) has another name called dwarf lilyturf, book band grass, Radix Ophiopogonis, Radix Ophiopogonis, is Liliaceae Ophiopogon perennial evergreen herbaceous plant.Fibrous root is more sturdy, and often expand at the top of root or middle part becomes spindle shape meat fritter, with tuber, is used as medicine.Its property of medicine: sweet, micro-hardship, be slightly cold; Return lung, stomach, heart channel.Function cures mainly: nourishing YIN and moistening the lung, reinforcing stomach reg fluid, relieving restlessness clears away heart-fire.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 1428-1429 page)

Particularly, the different name of the above-mentioned Radix Paeoniae Alba is Radix Paeoniae Alba, golden Radix Paeoniae.Its property of medicine: bitter, acid, be slightly cold; Return liver, spleen channel.Function cures mainly: the joint venture of nourishing blood, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 946-947 page)

Particularly, above-mentioned Flos Chrysanthemi different name is joint words, day essence, female's joint, more raw, Zhou Ying, Flos Chrysanthemi or true chrysanthemum etc.Its property of medicine: sweet, bitter, be slightly cold; Return lung, Liver Channel.Function cures mainly: wind and heat dispersing, suppressing the hyperactive liver improving eyesight, removing toxic substances and promoting subsidence of swelling.(< < Chinese medicine voluminous dictionary > >, Nanjing University of Traditional Chinese Medicine, Science and Technology of Shanghai publishing house, second edition, 2936-2938 page).

The present invention is except above-mentioned Chinese medicine composition is as effective ingredient, the pharmaceutical carrier that can also contain pharmaceutical field routine, comprise excipient, diluent, stabilizing agent and correctives etc., according to medical science conventional method, mix, the form of making tablet, capsule, granule, powder or syrup is oral.

Particularly, above-mentioned useful additives comprises excipient (for example carbohydrate derivative is as lactose, sucrose, glucose, mannitol and Sorbitol; Starch derivatives is as corn starch, potato starch, dextrin and carboxymethyl starch; Cellulose derivative is as crystalline cellulose, the third methylcellulose, carboxymethyl cellulose, carboxymethylcellulose calcium, sodium carboxymethyl cellulose; Arabic gum; Dextran; Silicate derivative is as Neusilin US2; Phosphonate derivatives is as calcium phosphate; Carbonate derivative is as calcium carbonate; Sulfate-derivatives is as calcium sulfate etc.), binding agent (such as gelatin, polyvinyl pyridine alkane ketone or Polyethylene Glycol), lubricant (such as Talcum, magnesium stearate, spermaceti or boric acid etc.), stabilizing agent (methyl parahydroxybenzoate, propyl p-hydroxybenzoate etc.), correctives (such as conventional sweeting agent, acidic flavoring agent and spice etc.), diluent (as water, ethanol etc.).

The administration of the medicine being comprised of said components is difference along with the difference of patient's age, sex and the state of an illness.The Chinese medicine composition that said components is formed is decocted to becoming medicine juice, each serving with 50 ~ 100ml, 2 times/day.Or Chinese medicine composition and additive that said components is formed are prepared into tablet, capsule, granule or syrup, each serving consumption, are above-mentioned effective ingredient 0.1 ~ 50mg/ day, and 3 times/day, wherein child and old people's dose reduces by half.Above-mentioned medicine juice, tablet, capsule, granule or syrup are taken and be take a week as the course for the treatment of, and be a treatment phase three courses for the treatment of.

The application of Chinese medicine composition of the present invention in xerophthalmia, curative effect obviously and there is no a drug resistance.

Beneficial effect of the present invention: Chinese medicine composition component wide material sources of the present invention, with low cost, safe, nontoxic.According to needs of patients, the forms such as the Chinese medicine decoction that above-mentioned composition can be made, tablet, capsule, granule or syrup facilitate patient to take, and wherein tablet, capsule, granule or syrup person easy to use carries simultaneously.Chinese medicine composition of the present invention is obvious for xerophthalmia curative effect, and does not produce drug resistance.

The specific embodiment

Below by the specific embodiment, further explain effect of Chinese medicine composition of the present invention and preparation method thereof.The present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.

1, Chinese medicine composition of the present invention forms

Embodiment 1

20 parts of 10 parts of Radix Rehmanniae, 7 parts of Radix Rehmanniae Preparata, 30 parts of Fructus Lycii, 8 parts of Fructus Corni, 12 parts of Rhizoma Dioscoreaes, 10 parts of Cortex Moutans, 18 parts of Rhizoma Alismatis, 10 parts, Poria, 10 parts, Radix Glycyrrhizae, 18 parts of Radix Scrophulariaes, 10 parts of Radix Ophiopogonis, 10 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Embodiment 2

18 parts of 15 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 25 parts of Fructus Lycii, 10 parts of Fructus Corni, 15 parts of Rhizoma Dioscoreaes, 10 parts of Cortex Moutans, 12 parts of Rhizoma Alismatis, 25 parts, Poria, 6 parts, Radix Glycyrrhizae, 10 parts of Radix Scrophulariaes, 15 parts of Radix Ophiopogonis, 12 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Embodiment 3

15 parts of 18 parts of Radix Rehmanniae, 25 parts of Radix Rehmanniae Preparata, 10 parts of Fructus Lycii, 20 parts of Fructus Corni, 12 parts of Rhizoma Dioscoreaes, 15 parts of Cortex Moutans, 12 parts of Rhizoma Alismatis, 20 parts, Poria, 8 parts, Radix Glycyrrhizae, 12 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 20 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Embodiment 4

15 parts of 30 parts of Radix Rehmanniae, 20 parts of Radix Rehmanniae Preparata, 18 parts of Fructus Lycii, 15 parts of Fructus Corni, 20 parts of Rhizoma Dioscoreaes, 20 parts of Cortex Moutans, 15 parts of Rhizoma Alismatis, 18 parts, Poria, 8 parts, Radix Glycyrrhizae, 15 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 15 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Embodiment 5

2 parts of 30 parts of Radix Rehmanniae, 25 parts of Radix Rehmanniae Preparata, 10 parts of Fructus Lycii, 8 parts of Fructus Corni, 12 parts of Rhizoma Dioscoreaes, 20 parts of Cortex Moutans, 10 parts of Rhizoma Alismatis, 20 parts, Poria, 4 parts, Radix Glycyrrhizae, 18 parts of Radix Scrophulariaes, 10 parts of Radix Ophiopogonis, 20 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Embodiment 6

4 parts of 20 parts of Radix Rehmanniae, 20 parts of Radix Rehmanniae Preparata, 15 parts of Fructus Lycii, 12 parts of Fructus Corni, 35 parts of Rhizoma Dioscoreaes, 20 parts of Cortex Moutans, 12 parts of Rhizoma Alismatis, 20 parts, Poria, 6 parts, Radix Glycyrrhizae, 15 parts of Radix Scrophulariaes, 10 parts of Radix Ophiopogonis, 15 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Embodiment 7

10 parts of 15 parts of Radix Rehmanniae, 12 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Lycii, 12 parts of Fructus Corni, 18 parts of Rhizoma Dioscoreaes, 15 parts of Cortex Moutans, 12 parts of Rhizoma Alismatis, 27 parts, Poria, 8 parts, Radix Glycyrrhizae, 10 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 12 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

Embodiment 8

6 parts of 20 parts of Radix Rehmanniae, 15 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Lycii, 12 parts of Fructus Corni, 20 parts of Rhizoma Dioscoreaes, 10 parts of Cortex Moutans, 9 parts of Rhizoma Alismatis, 20 parts, Poria, 6 parts, Radix Glycyrrhizae, 10 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 15 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

The Chinese medicine that above-mentioned weight portion is formed makes decoction by the mode of general Traditional medicine infusion, each by the gross dry weight of 500g Chinese medicine, then adds water to Chinese medicine and is submerged and decocts 6 ~ 12ml and obtain 150ml decoction juice through decocting 20 ~ 40min.Finally with each oral 50 ~ 100ml, (child and old people garment are with 50ml/ time; Be grown up 100ml/ time), every day twice, take a week as a course for the treatment of, take continuously two state of an illness of observing patient the course for the treatment of, be wherein a complete treatment phase three courses for the treatment of.

The Chinese medicine composition being comprised of above-mentioned weight portion and additive are to be prepared into tablet, granule, capsule or syrup, the additive wherein adding is one or more in excipient, diluent, stabilizing agent or correctives, adds the weight of additive to account for 0.5 ~ 300% of Chinese medicine composition dry weight gross weight.

Embodiment 9

The dry weight of the Chinese medicine composition gross weight of 15 parts of Radix Rehmanniae, 12 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Lycii, 12 parts of Fructus Corni, 18 parts of Rhizoma Dioscoreaes, 25 parts of Cortex Moutans, 12 parts of Rhizoma Alismatis, 27 parts, Poria, 8 parts, Radix Glycyrrhizae, 10 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 12 parts of the Radix Paeoniae Albas and 10 parts of compositions of Flos Chrysanthemi is 2.01kg, above-mentioned each component water is cleaned and removes dust or impurity, drain, be dried, then pulverize and to obtain the particle diameter powder that is 5 ~ 100nm; Then add sucrose 4.2g, dextrin 2.5g and gelatin 10.5g mix homogeneously, through comminutor molding, obtain the spherical or ellipsoidal particle of 2 ~ 10mm.

Embodiment 10

The Chinese medicine composition gross weight dry weight basis 4.58kg of 30 parts of Radix Rehmanniae, 20 parts of Radix Rehmanniae Preparata, 18 parts of Fructus Lycii, 15 parts of Fructus Corni, 20 parts of Rhizoma Dioscoreaes, 20 parts of Cortex Moutans, 15 parts of Rhizoma Alismatis, 18 parts, Poria, 8 parts, Radix Glycyrrhizae, 15 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 15 parts of the Radix Paeoniae Albas and 15 parts of compositions of Flos Chrysanthemi, then water cleans, drains, dries, pulverizes and to obtain 10 ~ 20nm powder.Then by gelatin 100g, corn starch 50g, lactose 120g and distilled water water mix homogeneously under gnotobasis, then through flour mill, wear into the granule of 1 ~ 2mm, be finally distributed into the capsule of 0.05 ~ 0.2g/.

Embodiment 11

The dry weight basis 5.19kg of the Chinese medicine composition gross weight of 10 parts of Radix Rehmanniae, 7 parts of Radix Rehmanniae Preparata, 30 parts of Fructus Lycii, 8 parts of Fructus Corni, 12 parts of Rhizoma Dioscoreaes, 10 parts of Cortex Moutans, 18 parts of Rhizoma Alismatis, 10 parts, Poria, 10 parts, Radix Glycyrrhizae, 18 parts of Radix Scrophulariaes, 10 parts of Radix Ophiopogonis, 10 parts of the Radix Paeoniae Albas and 20 parts of compositions of Flos Chrysanthemi.By above-mentioned Chinese medicine composition through cleaning, drain, dry, then use 55wt% ethyl alcohol purification, macroporous resin adsorption, rotary evaporation fraction then, vacuum drying obtains the powder of sallow; Finally above-mentioned powder is added glucose 150g, Sorbitol 20g and distilled water 12kg to be prepared into syrup, last high pressure degerming, be divided in 10 ~ 20ml bottle.

2, clinical trial

Below to 130 routine dry eye patients, the treatment by Chinese herbs and the simple Therapeutic Method that uses Polyethylene Glycol eye drop that to this, adopt respectively the above-mentioned decoction of Polyethylene Glycol eye drop Combined with Oral to make, the curative effect that paired observation is 2 groups.

Clinical data

1), dry eye patients 130 examples (260 eyes), patient age is 14 ~ 75 years old, male's 51 examples (102 eyes) wherein, women's 79 examples (158 eyes).Patient's eyes lesion degree is similar, and in patient, M-F is evenly distributed at each age level.These patients' clinical symptoms performance: (1) eye sensation of dryness, burn feeling, foreign body sensation, prickling sensation, ophthalmic pruritus, photophobia, furious, blurred vision, vision fluctuation, can not tolerate the environment of flue dust etc.(2) breakup time of tear film (breakup time, BUT)≤5s and Schimer's test (schirmer I test, S I t)≤5mm/5min; In addition above-mentioned patient gets rid of the situation of whole body relevant disease and recent medication history.

2), process of the test: by above-mentioned 130 routine patients (260 eyes), be divided at random two groups: treatment group and matched group, every group of 65 examples (130 eyes).For treatment group, adopt Polyethylene Glycol eye drop 4 eye drip Combined with Oral Chinese medicines every day, every day, potion, divided morning, late twice oral form to follow the tracks of the state of an illness.Matched group: the mode that adopts Polyethylene Glycol eye drop 4 eye drips every day.Two groups of treatments are 1 month the course for the treatment of.

Wherein, the medicine juice obtaining for the Chinese medicine decoction by conventional, according to one day twice, each serving using medicine juice 50 ~ 100ml.(be wherein grown up each serving with 100ml, discontented 16 years old child and over 60 old man's dose, be 50ml).

3), test result analysis: application SPSS17.0 statistical software carries out date processing, and data represent with mean ± standard deviation, compare two groups of indices for the treatment of after front and treatment with t check.In group, relatively use paired t-test, between group, relatively adopt independent sample t check.With P < 0.05, judge that difference has statistical significance.

4), result: BUT and the S I t Index for examination not statistically significant (P > 0.05) for the treatment of group and matched group before treatment.Treat after 1 month, two groups of patient's symptoms all have clear improvement or remission, and treatment group and matched group curative effect see attached list.Two groups of rear BUT for the treatment of are relatively front with treatment, and difference has statistical significance (P < 0.05), after treatment group S I t treats with before treating, compare, and difference has statistical significance (P < 0.05); After treatment between two groups of BUT, S I t relatively, difference has statistical significance (P < 0.05).

5), conclusion: dry eye patients adopts the treatment by Chinese herbs of tear composition replacement therapy Combined with Oral, can regulating body function, thereby improve lacrimal secretion, stablize tear film, improve xerophthalmia symptom, in follow-up investigation discovery subsequently, there is no the situation of drug resistance; The simple dry eye patients that adopts eye drop form of therapy, its successful, but there is outstanding drug resistance, once stop using, symptomatic recurrence.

Two groups of result comparisons before and after table 1 medication

Note: △: with this group before treatment, P ﹤ 0.05; ☆: with comparison after treatment of control group, P ﹤ 0.05.

Claims (6)

1. a Chinese medicine composition, is characterized in that: the effective ingredient of this Chinese medicine composition is comprised of the component of following weight portion: 2 ~ 20 parts of 10 ~ 30 parts of Radix Rehmanniae, 7 ~ 25 parts of Radix Rehmanniae Preparata, 10 ~ 30 parts of Fructus Lycii, 8 ~ 20 parts of Fructus Corni, 12 ~ 35 parts of Rhizoma Dioscoreaes, 5 ~ 20 parts of Cortex Moutans, 5 ~ 18 parts of Rhizoma Alismatis, 10 ~ 30 parts, Poria, 4 ~ 10 parts, Radix Glycyrrhizae, 7 ~ 18 parts of Radix Scrophulariaes, 10 ~ 30 parts of Radix Ophiopogonis, 10 ~ 20 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

2. Chinese medicine composition according to claim 1, is characterized in that: the effective ingredient of above-mentioned Chinese medicine composition is comprised of the component of following weight portion: 6 ~ 15 parts of 15 ~ 25 parts of Radix Rehmanniae, 12 ~ 20 parts of Radix Rehmanniae Preparata, 15 ~ 25 parts of Fructus Lycii, 12 ~ 15 parts of Fructus Corni, 18 ~ 25 parts of Rhizoma Dioscoreaes, 10 ~ 15 parts of Cortex Moutans, 9 ~ 12 parts of Rhizoma Alismatis, 15 ~ 27 parts, Poria, 6 ~ 8 parts, Radix Glycyrrhizae, 10 ~ 12 parts of Radix Scrophulariaes, 20 ~ 25 parts of Radix Ophiopogonis, 12 ~ 15 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

3. Chinese medicine composition according to claim 1, is characterized in that: the effective ingredient of above-mentioned Chinese medicine composition is comprised of the component of following weight portion: 6 parts of 20 parts of Radix Rehmanniae, 15 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Lycii, 12 parts of Fructus Corni, 20 parts of Rhizoma Dioscoreaes, 10 parts of Cortex Moutans, 9 parts of Rhizoma Alismatis, 20 parts, Poria, 6 parts, Radix Glycyrrhizae, 10 parts of Radix Scrophulariaes, 20 parts of Radix Ophiopogonis, 15 parts of the Radix Paeoniae Albas and Flos Chrysanthemis.

4. the Chinese medicine composition described in claim 1 ~ 3, is characterized in that: the Chinese medicine composition being comprised of said components weight portion adds additive to make Chinese medicine decoction, tablet, capsule, granule or syrup.

5. Chinese medicine composition claimed in claim 4, is characterized in that: described additive is excipient, diluent, stabilizing agent or correctives.

6. the Chinese medicine composition described in claim 1 ~ 3, is characterized in that: the application of above-mentioned Chinese medicine composition in xerophthalmia.