CN102526345B - Chinese medicinal composition for treating hypertension - Google Patents
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Abstract
The invention discloses a Chinese medicinal composition for treating hypertension, and relates to the technical field of Chinese medicaments. The composition is prepared from 8 gouts of purely natural Chinese medicinal materials such as Chinese prickly ash, cassia seed, raw hawthorn, Chinese angelica, self-heal, Chinese wolfberry, snakegourd fruit and coptis in a specified ratio. The Chinese medicinal composition for treating the hypertension has the advantages of high healing rate, relapse prevention, no toxic or side effect, low cost, simplicity in preparation process and the like.
Description
Technical field
The present invention relates to the Chinese medicine technical field, be specifically related to a kind of hypertensive pharmaceutical composition and preparation method thereof for the treatment of.
Background technology
Hypertension (hypertensive disease) is a kind of chronic disease that serves as main performance with the lasting rising of arteriotony, can be functional with heart, blood vessel, brain and kidney and other organs or the systemic disease of organic change, be the great public health problem in the global range.According to up-to-date calculation of measured data, the ill crowd of China's hypertension surpasses 200,000,000.It still is the fuse cord of multiple disease that hypertension raises, and the onset risk of diseases such as coronary heart disease, heart failure and kidney disease is increased.Because the part hyperpietic there is no tangible clinical symptoms, hypertension be otherwise known as " the invisible killer " of human health.Therefore improve the understanding to hypertension, early prevention, treatment are in time had extremely important meaning.
Doctor trained in Western medicine thinks that hypertension is a kind of disease that can not cure, can only lean on enalapril meleate (Western medicine) to keep the stable of blood pressure.But practical situation is the prolongation along with the time, and the state of an illness increases the weight of gradually, and serious meeting causes diseases such as patient's cerebral hemorrhage, cerebral embolism, hemiplegia.
The hypertensive Chinese medicine compound of existing treatment has multiple at present, for example CN200710015375.5 discloses a kind of Chinese medicinal capsule of the person in middle and old age's for the treatment of essential hypertension, be by the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Fructus Mori, Fructus Ligustri Lucidi, Semen Astragali Complanati, Fructus Tribuli, Herba Cynomorii, Radix Achyranthis Bidentatae, Semen Cuscutae, Semen Raphani, Rhizoma Atractylodis Macrocephalae (parched), Fructus Lycii, Semen Plantaginis, Semen Cassiae, Flos Chrysanthemi, Radix Polygalae (processing), Rhizoma Acori Graminei each, the formulated Chinese medicinal capsule of Herba Asari.CN200610165007.4 discloses a kind of hypertensive Chinese medicine oral liquid for the treatment of, and it is that raw material is made with Semen Persicae, Radix Platycodonis, Concha Haliotidis, Flos Carthami, Radix Bupleuri, Fructus Gardeniae, Radix Angelicae Sinensis, Fructus Aurantii, Poria cum Radix Pini, Radix Rehmanniae, Radix Glycyrrhizae, Radix Scutellariae, Rhizoma Chuanxiong, Rhizoma Gastrodiae, the Cortex Eucommiae, Radix Paeoniae Rubra, Ramulus Uncariae Cum Uncis, Herba Leonuri, Radix Cyathulae, Semen Cassiae, Herba Taxilli, Caulis Polygoni Multiflori.CN201010187963.9 discloses a kind of hypertensive Chinese medicine for the treatment of, by weight, formulated by following component: 20 parts of Ramulus Uncariae Cum Uncis, 20 parts of Concha Haliotidis, 15 parts of the Cortexs Eucommiae, 15 parts of Radix Puerariaes, 20 parts of Semen Cassiaes, 15 parts of Cortex Moutans, 10 parts of Radix Scutellariaes, 10 parts of Cortex Lycii, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Bupleuri, 10 parts in Rhizoma Gastrodiae, 15 parts of Radix Achyranthis Bidentataes, 15 parts of Herba Taxillis, 15 parts of Pheretimas, 15 parts of Herba Leonuris, 15 parts of Caulis Polygoni Multiflori.
The hypertensive Chinese medicine product of above-mentioned treatment, pay attention to too much regulating, used taste of Chinese medicine number is too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course for the treatment of is long, and effect is undesirable, and existing Chinese medicine is owing to mostly be decoction or the pill that boils, take difficulty than Western medicine, also influenced the popularization of Chinese medicine widely.
Summary of the invention
The object of the present invention is to provide a kind of reasonable recipe, flavour of a drug are simplified, determined curative effect, short treating period, instant effect, the suitable hypertensive Chinese medicine compositions for the treatment of oral, safe and reliable, that price is low.
In order to realize purpose of the present invention, Chinese medicine composition of the present invention is made by the raw material of following weight portion: Pericarpium Zanthoxyli 4-27 part, Semen Cassiae 4-27 part, Fructus Crataegi 5-30 part, Radix Angelicae Sinensis 3-30 part, Spica Prunellae 2-30 part, Fructus Lycii 4-30 part, Fructus Trichosanthis 4-30 part, Rhizoma Coptidis 2-18 part.
Preferably, Chinese medicine composition of the present invention is made by the raw material of following weight portion: 22 parts in Pericarpium Zanthoxyli, 18 parts of Semen Cassiaes, 24 parts of Fructus Crataegi, 24 parts of Radix Angelicae Sinensis, 24 parts of Spica Prunellaes, 18 parts of Fructus Lyciis, 20 parts of Fructus Trichosanthis, 8 parts of Rhizoma Coptidis.
The present invention is based on opening one's minds of traditional Chinese medical science the five internal organs differentiation of syndromes of YIN and YANG guiding principle, the deficiency of YIN is this, and yang hyperactivity is mark, and pathological changes is relevant with the five internal organs, and the main heart, liver, the kidney of relating to is being designated as liver, is kidney at this.Chinese medicine composition of the present invention can the conditioning viscera function, recovers equilibrium between yin and yang, but treating the liver deficiency of the kidney yin or excessive rising of liver-YANG, control is cloudy decrease in preceding yang hyperactivity in after deficiency of both YIN and YANG.
In the prescription of the present invention, Rhizoma Coptidis: bitter in the mouth, cold.Cure mainly steam, ophthalmalgia, the corner of the eyes is hindered, and delacrimation makes eye bright, intestinal Bleach, stomachache, dysentery swells and ache in married woman's the moon.Clothes make us not forgetting for a long time.Pericarpium Zanthoxyli: acrid in the mouth, warm in nature.Slightly poisonous.Return spleen, stomach, kidney channel.Can promote salivation, increase appetite; The effect that distends the blood vessels.Semen Cassiae: sweet, bitter, salty, be slightly cold.Return liver, large intestine channel.Liver heat removing and eyesight improving, the diuretic relieving constipation.The treating the liver inflammation, cirrhotic ascites, hypertension, infantile malnutrition, nyctalopia, wind heat ophthalmalgia, habitual constipation.Fructus Crataegi: slightly warm in nature, sour in the mouth is sweet, goes into spleen, stomach, Liver Channel.Have blood vessel dilating, heart tonifying, increase coronary flow, improve heart vigor, stimulating central nervous system system, bring high blood pressure down and cholesterol, vessel softening and diuresis and sedation.Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature.Can enrich blood, invigorate blood circulation, regulating menstruation, pain relieving, intestine moistening.Be used for blood deficiency, shallow complexion, dizzy cardiopalmus; Blood deficiency, or have menoxenia, amenorrhea, the dysmenorrhea that the stasis of blood stagnates concurrently; Deficiency and coldness stomachache, angina pectoris.Spica Prunellae: bitter, hot, cold.Control conjunctival congestion and swelling pain, headache.Clearing away liver-fire, control hypertension, hyperlipidemia, high blood viscosity and hyperglycemia.Fructus Lycii: sweet in the mouth; The flat nourishing the liver of property; Nourishing kidney; Lung moistening.Have the enhancing human body immunity function, suppress tumor, blood sugar lowering, blood fat reducing, functions such as resisting fatigue.Fructus Trichosanthis: sweet, little hardship, cold.GUIXIN, lung, liver, stomach, large intestine channel.Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens is moisturized laxation.Be used for the cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia.More than all medicine 5 usefulness, conditioning viscera, Yin Yang balancing, the appetizing of being amusing, clearing away liver-fire, activating blood circulation to dissipate blood stasis, blood vessel dilating, blood fat-reducing blood pressure-decreasing.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
According to Clinical Experience, Chinese medicine composition of the present invention is preferably capsule, and concrete preparation method is as follows: Rhizoma Coptidis, Semen Cassiae, Fructus Crataegi, Spica Prunellae, Fructus Lycii, Fructus Trichosanthis, Pericarpium Zanthoxyli, Radix Angelicae Sinensis according to weight proportion of the present invention takes by weighing, clean, and dry; With above-mentioned pulverizing medicinal materials, cross 120 mesh sieves, insert capsule after the sterilization, every content of dispersion 0.4 gram.
Usage and dosage: dosage of the present invention depends on concrete dosage form, factors such as patient age, body weight, health status.Capsule of the present invention is every day twice, obeys 2～4 at every turn, and warm water takes.15 days courses for the treatment of.
Chinese medicine composition of the present invention through inventor's exploration for many years, by rational compatibility, has reduced the Chinese medicine taking dose on the basis of secret prescription handed down in the family from generation to generation, reduced the stimulation of medicine to the intestines and stomach.Chinese medicine composition of the present invention has the following advantages with respect to prior art: compatibility is simplified, and cure rate is high and be difficult for recurrence, has no side effect, and raw material is easy to get, and is with low cost, and preparation process is simple.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not to be limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
EXAMPLE l: weighting raw materials material Pericarpium Zanthoxyli 22g, Semen Cassiae 18g, Fructus Crataegi 24g, Radix Angelicae Sinensis 24g, Spica Prunellae 24g, Fructus Lycii 18g, Fructus Trichosanthis 20g, Rhizoma Coptidis 8g.Clean, dry, pulverize, cross 120 mesh sieves, insert capsule then No. 0, adorn 0. 4g for every, namely get capsule of the present invention.
Embodiment 2: weighting raw materials material Pericarpium Zanthoxyli 27g, Semen Cassiae 27g, Fructus Crataegi 30g, Radix Angelicae Sinensis 30g, Spica Prunellae 30g, Fructus Lycii 30g, Fructus Trichosanthis 30g, Rhizoma Coptidis 18g, and clean, dry, pulverize, cross 120 mesh sieves, insert capsule then No. 0, adorn 0. 4g for every, namely get capsule of the present invention.
Embodiment 3: weighting raw materials material Pericarpium Zanthoxyli 4g, Semen Cassiae 4g, Fructus Crataegi 5g, Radix Angelicae Sinensis 3g, Spica Prunellae 2g, Fructus Lycii 4g, Fructus Trichosanthis 4g, Rhizoma Coptidis 2g, and clean, dry, pulverize, cross 120 mesh sieves, insert capsule then No. 0, adorn 0. 4g for every, namely get capsule of the present invention.
Embodiment 4: weighting raw materials material Pericarpium Zanthoxyli 15g, Semen Cassiae 18g, Fructus Crataegi 18g, Radix Angelicae Sinensis 20g, Spica Prunellae 18g, Fructus Lycii 20g, Fructus Trichosanthis 8g, Rhizoma Coptidis 6g, and clean, dry, pulverize, cross 120 mesh sieves, insert capsule then No. 0, adorn 0. 4g for every, namely get capsule of the present invention.
Pharmacodynamic experiment
1, animal acute toxicity test of the present invention
Medicine: the embodiment of the invention 1 prescription.
Experimental animal: 12 of regular grade NIH mices, body weight 18g ± 2g, male and female half and half.
Method and result:
1) medicine preparation: get the medicine of embodiment 1, be assigned to the 200g/L suspension with the normal saline that contains 2% Radix Acaciae senegalis:
2) the gastric infusion mode is adopted in experiment.Disposable administration, volume 2ml/100g body weight, close observation 8h also notes down, and continues to observe 7d;
3) mice does not have death among the 7d, and behavior is active, and food ration is as usual, and the hair color light does not have loose dirty, and not having faints from fear has a liking for saliva, and eye, mouth, nose, ear and the no abnormal secretions of crissum do not have the mashed toe of docking.Select 5 execution, finding of naked eye: important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes, and shows the oral safety of this medicine.
Long-term toxicity test for animals of the present invention
Medicine: the embodiment of the invention 1 prescription.
Animal: 24 of regular grade SD rats, body weight 200g ± 10g, male and female half and half are divided into 3 groups at random.
Method and result:
1) medicine preparation: divide high, medium and low three dosage groups, be respectively 300,150,75 times of clinical application amount, mix with the normal saline 1:1 that contains 2% Radix Acaciae senegalis;
2) the gastric infusion mode is adopted in experiment, successive administration 45d, namely more than 3 clinical cycles, observe animal general toxic reaction and the order of severity, put to death the back and check each position by rule of operation, and carry out hematology, the pathological examination of main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach;
3) long-term oral administration, toxic reaction does not appear in high, medium and low three dosage treated animals.Physically well develop.Naked eyes outward appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN and matched group relatively do not have pathologic and change.All not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach are thought to confirm that through pathology animal is not had poisoning manifestations.
Clinical model case:
Diagnosis basis: determine according to the new hypertension therapeutic guide that World Health Organization (WHO)/International Society of Hypertension (WHO/ISH) promulgates, namely do not taking under the antihypertensive drugs, systolic pressure 〉=18.7kPa(140mmHg) and (or) diastolic pressure 〉=12.0kPa (90mmHg), unless blood pressure extremely raises and merges relevant clinical disease (last target organ damage eventually) certainly, can not be only according to a blood pressure measurement diagnosis primary disease.After hypertension is found in pressure measurement first, should measure to determine whether blood pressure raises twice different occasion at least.
Criterion of therapeutical effect: cure and be systolic pressure≤18.7kPa(140mmHg) and diastolic pressure≤12.0kPa(90mmHg).Effectively be systolic pressure 〉=18.7kPa(140mmHg) with (or) diastolic pressure 〉=12.0kPa (90mmHg), but blood pressure decreases.Invalid is the blood pressure no change, other severity of symptoms.
Experimental result: 300 routine hyperpietics, take Chinese medicine of the present invention according to the method for the invention, to schedule to last 280 of healing persons, 18 of responders, 2 of nonresponders, total effective rate＞99% half a year.
Model case
Case 1. Lee, man 50 years old, at examination in hospital, it is 173/109 that blood pressure detects numerical value, takes the capsule that the embodiment of the invention 1 makes, and takes 2 times in one day, once takes 4, has taken after 45 days blood pressure continuously and has detected numerical value and become 126/63.After the drug withdrawal in 6 months regular return visit detect blood pressure and do not have risings, rebound, there is no other senses of discomfort.
Case 2. Lee, woman 40 years old, at examination in hospital, it is 155/98 that blood pressure detects numerical value, takes the capsule that the embodiment of the invention 1 makes, and takes 2 times in one day, once takes 3, has taken after 30 days blood pressure continuously and has detected numerical value and become 120/70.After the drug withdrawal in 6 months regular return visit detect blood pressure and do not have risings, rebound, there is no other senses of discomfort.
Case 3. Wang, woman 68 years old, at examination in hospital, it is 180/110 that blood pressure detects numerical value, takes the capsule that the embodiment of the invention 2 makes, and takes 2 times in one day, once takes 4, has taken after 60 days blood pressure continuously and has detected numerical value and become 128/80.After the drug withdrawal in 6 months regular return visit detect blood pressure and do not have risings, rebound, there is no other senses of discomfort.
Case 4. tall certain, man 61 years old, at examination in hospital, it is 174/99 that blood pressure detects numerical value, takes the capsule that the embodiment of the invention 3 makes, and takes 2 times in one day, once takes 4, has taken after 60 days blood pressure continuously and has detected numerical value and become 125/68.After the drug withdrawal in 6 months regular return visit detect blood pressure and do not have risings, rebound, there is no other senses of discomfort.
Case 5. neat certain, man 32 years old, at examination in hospital, it is 150/96 that blood pressure detects numerical value, takes the capsule that the embodiment of the invention 4 makes, and takes 2 times in one day, once takes 4, has taken after 45 days blood pressure continuously and has detected numerical value and become 125/68.After the drug withdrawal in 6 months regular return visit detect blood pressure and do not have risings, rebound, there is no other senses of discomfort.
Case 6. Wang, man 35 years old, at examination in hospital, it is 148/94 that blood pressure detects numerical value, takes the capsule that the embodiment of the invention 1 makes, and takes 2 times in one day, once takes 2, has taken after 30 days blood pressure continuously and has detected numerical value and become 115/72.After the drug withdrawal in 6 months regular return visit detect blood pressure and do not have risings, rebound, there is no other senses of discomfort.
All cases that the non-the present invention of above case cures, only enumerate comparatively clearly case of record, good by the visible therapeutic effect of the present invention of above model case, improve high blood coagulation state, the mediation microcirculation, invigorating blood circulation be tired, blood fat, nourishing yin and purging fire, blood is capable unimpeded, voltage stabilizing does not rebound, and alleviates the generation of hypertension complication.
Claims (3)
1. the hypertensive Chinese medicine composition for the treatment of is characterized in that being made by the raw material of following weight portion: 22 parts in Pericarpium Zanthoxyli, 18 parts of Semen Cassiaes, 24 parts of Fructus Crataegi, 24 parts of Radix Angelicae Sinensis, 24 parts of Spica Prunellaes, 18 parts of Fructus Lyciis, 20 parts of Fructus Trichosanthis, 8 parts of Rhizoma Coptidis.
2. the hypertensive Chinese medicine composition for the treatment of as claimed in claim 1, it is characterized in that: described Chinese medicine composition is peroral dosage form.
3. the hypertensive Chinese medicine composition for the treatment of as claimed in claim 2, it is characterized in that: described peroral dosage form is capsule.
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| CN103405574B (en) * | 2013-07-31 | 2014-12-24 | 王桂霞 | Medicinal composition for treating hypertension |
| CN104013699B (en) * | 2014-06-17 | 2015-05-06 | 梁存福 | Pharmaceutical composition for treating hypertension caused by hyperactivity of liver-yang |
| CN105770496A (en) * | 2016-04-08 | 2016-07-20 | 烟台市蓝洋之草医药生物科技有限公司 | Pharmaceutical composition for treating high blood pressure |
| CN107822118A (en) * | 2017-11-14 | 2018-03-23 | 天津港保税区爱信食品有限公司 | A kind of formula and preparation method of the black tartary buckwheat oatmeal of integration of drinking and medicinal herbs hypertension prevention |
| CN108815365A (en) * | 2018-07-18 | 2018-11-16 | 合肥华盖生物科技有限公司 | A kind of Chinese medicine composition for treating hypertension |
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