CN103638456B - A kind of Chinese medicine for the treatment of liver cirrhosis and preparation method thereof - Google Patents
A kind of Chinese medicine for the treatment of liver cirrhosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine for the treatment of liver cirrhosis, be made up of the crude drug of following weight: Radix Curcumae 180g, Herba Artemisiae Scopariae 300g, Radix Aucklandiae 120g, Pericarpium Citri Reticulatae Viride 120g, Rhizoma Cyperi 120g, Fructus Citri Sarcodactylis 120g, Fructus Aurantii (parched) 120g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Astragali Preparata 120g, Poria 300g, Fructus Chaenomelis 180g, Pericarpium Arecae 180g, Radix Paeoniae Alba 150g, Cortex Moutan 90g, Rhizoma Imperatae 300g, Rhizoma Corydalis 120g, Cortex Cinnamomi 90g, Fructus Forsythiae 200g, Radix Glycyrrhizae Preparata 60g; 20 grams, Iuba Equi; And honeyed pill is soft and moist, drug effect is gentle, and the efficacy of a drug is lasting, and be convenient to preserve the property of medicine, taking convenience, is beneficial to and carries, and is convenient to storage, exempts Chinese medicine and decocts medicinal herbs loaded down with trivial details, difficult clothes of bitter in the mouth, the deficiency that should not be long placed in.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of liver cirrhosis and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Liver cirrhosis is a kind of common chronic, Progressive symmetric erythrokeratodermia, DHD of being caused by different pathogeny.Have the advantages that sickness rate is high, the course of disease is long, case fatality rate is high.Liver cirrhosis onset is often hidden, in early days can without specific symptom, sign, and occur the multiple complications such as portal hypertension, cirrhotic ascites, hepatic encephalopathy late period, fatality rate is high.
Liver cirrhosis, the traditional Chinese medical science belongs to more " gathering ", " tympanites ", “ mass in the abdomen " category.Show as enlarged abdomen distension, hypochondriac pain, poor appetite, weak, oliguria clinical, tongue is dark red, tongue is thick in vain, stringy and rolling pulse more.Analyse its etiology and pathogenesis, how because of impairing the liver spleen in poison heresy, feelings will, diet, with the passing of time the course of disease, injures in kidney, and liver spleen kidney is lacked of proper care mutually, causes the stagnation of QI, phlegm-damp, blood stasis gather and form in abdomen, control suitable circulation of qi promoting liver resolving depression, invigorating the spleen and benefiting QI righting, blood circulation promoting and blood stasis dispelling removing food stagnancy.
Western medical treatment there is no therapy and the Chinese medicine of specially good effect at present to primary disease, main the liver protecting and ALT lowering, antiviral, diuresis symptomatic treatment, and clinical efficacy is not satisfied, especially patients with cirrhosis ascites diuretic in late period cannot prove effective, patient is deeply painful by illness, and side effect is large, very big to the damage of human body.
Chinese medicine becomes increasingly conspicuous with the advantage that its side effect is little, but at present determined curative effect, safe and reliable Chinese medicine preparation are little, therefore researchs and develops this kind of Chinese medicine and have significant social and economic significance.
Summary of the invention
The problem to be solved in the present invention is for above problem, provides a kind of Chinese medicine for the treatment of liver cirrhosis and preparation method thereof, and use treatment by Chinese herbs liver cirrhosis prepared by the present invention, therapeutic effect is good, little to the side effect of health.
For overcoming the above problems, technical scheme of the present invention is:
Treat a Chinese medicine for liver cirrhosis, be made up of the crude drug of following weight: Radix Curcumae 180g, Herba Artemisiae Scopariae 300g, Radix Aucklandiae 120g, Pericarpium Citri Reticulatae Viride 120g, Rhizoma Cyperi 120g, Fructus Citri Sarcodactylis 120g, Fructus Aurantii (parched) 120g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Astragali Preparata 120g, Poria 300g, Fructus Chaenomelis 180g, Pericarpium Arecae 180g, Radix Paeoniae Alba 150g, Cortex Moutan 90g, Rhizoma Imperatae 300g, Rhizoma Corydalis 120g, Cortex Cinnamomi 90g, Fructus Forsythiae 200g, Radix Glycyrrhizae Preparata 60g; 20 grams, Iuba Equi.
Treat a preparation method for the Chinese medicine of liver cirrhosis, comprise the following steps:
1), for medicine, according to above-mentioned weight, Chinese medicine is assorted;
2), pulverizing, by the Radix Curcumae of above-mentioned weight, Herba Artemisiae Scopariae, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Aurantii (parched), Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Preparata, Poria, Fructus Chaenomelis, Pericarpium Arecae, the Radix Paeoniae Alba, Cortex Moutan, Rhizoma Imperatae, Rhizoma Corydalis, Cortex Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae Preparata, pulverize, obtain medicamental pulverata A;
3), by the Iuba Equi of above-mentioned weight burn till carbon shape, wear into fine powder and obtain fine powder B;
4), by medicamental pulverata A and fine powder B mix homogeneously, medicated powder is obtained;
5), refined honey: choose the high-quality Mel without impurity such as offscum, dead honeybees, add appropriate clear water, mulse total amount is no more than 1/3 of pot, in case excessive during heating, heated and boiled; Be heated to 116 ~ 118 DEG C, in panful, occur the goods of even faint yellow thin bubble, obtained refined honey;
6), close medicine: mixed with the ratio of medicated powder in 1:1 by the refined honey refined, stir, leave standstill 6-14 minute after stirring, then make pill.
Below the further improvement to technique scheme:
The order number of medicamental pulverata A is at 80-160 order.
In step 5, obtained refined honey water content is 10 ~ 13%.
In step 6, when refined honey and medicated powder mixing, the temperature of refined honey controls at 116 ~ 118 DEG C.
In step 6, refined honey carries out mixing latter standing 10 minutes in the ratio of 1:1 with medicated powder; Leave standstill that medicated powder within 10 minutes, can be made mix with honey component is moist, and get final product rubbing pill after producing certain viscosity.
During treatment, each serving with 9g, point sooner or later within 1 hour after meal, to take, serveing on 8 weeks was 1 course for the treatment of, and after 1 course for the treatment of, symptom can greatly be alleviated, and general 2-3 both can fully recover a course for the treatment of.
Herba Artemisiae Scopariae bitter energy dampness, the heat clearing away of cold energy, its gas delicate fragrance, enters spleen, stomach, liver, gallbladder meridian, and merit is apt to removing damp-heat jaundice eliminating; Radix Curcumae pungent drugs can disperse and bitter drugs can descend, fragrance a surname reach, and enters edema caused by disorder of QI with promoting QI circulation for relieving depression, enter blood system with removing heat from blood removing blood stasis with potent drugs, have the merit of promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, promoting the function of the gallbladder to alleviate jaundice, Radix Aucklandiae aroma is strong and rich, and fragrance is warded off dirt eliminating and disliked, its acrid in the mouth, gas can rise, and the stagnation of QI does not reach person and should it, for adjusting the key medicine of all gas; The gas of Rhizoma Cyperi is flat and do not tremble with fear, and is longer than soothing the liver circulation of qi promoting, to separate stagnation of liver-QI; The pungent temperature of Fructus Citri Sarcodactylis property, regulating the flow of Qi and the middle Jiao, dispersing the stagnated live-QI to relieve the stagnation of QI; The main stagnation of QI of Pericarpium Citri Reticulatae Viride, depressed liver-energy dispersing and QI regulating, removing food stagnancyization is stagnant, relieving stagnant and resolving masses; Fructus Chaenomelis fragrance is amusing, dispelling dampness and promoting diuresis, with the emerging merit that The spleen has the function to transport and transform nutrients; Poria is sweet lightly oozes profit, and promoting diuresis to eliminate damp pathogen is held concurrently and helped transporting with spleen reinforcing; Radix Astragali Preparata QI invigorating righting and can promoting the circulation of QI for relieving swelling; Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI righting; Fructus Aurantii (parched) gasified is stagnant, relieving distension and oppression; Pericarpium Arecae therapeutic method to keep the adverse QI flowing downwards intestinal stasis relieving, relieving distension by promoting circulation of QI, Xuan Li stops up stagnant; The Radix Paeoniae Alba receives liver and yin fluid astringing, and few sun and adjust irritability, and blood circulation promoting and blood stasis dispelling, diuresis.Rhizoma corydalis, the stagnation of QI in promoting the circulation of blood, stasis in gas, dispersing liver-energy, removing fire from the liver, smooth blood, relieve the pain pain.Rhizoma Imperatae is sweet cold, the heat to purify the blood point, cooling blood for hemostasis, and drop-down fire is inverse; Blood because of the poly-then heat of heresy, therefore to be dehematized the fire second of the three ten-day periods of the hot season with Cortex Moutan, with Cortex Cinnamomi using corrigent it, promoting the flow of QI-blood by warming the meridian promote the circulation of qi and water.Fructus Forsythiae heat-clearing and toxic substances removing eliminating stagnation, has good sterilization and antivirus action; Radix Glycyrrhizae ridging and in, coordinating the actions of various ingredients in a prescription.
The present invention with Herba Artemisiae Scopariae, Radix Curcumae for monarch, liver clearing and depression relieving, function of gallbladder promoting damp eliminating, plays the effect of liver heat removing function of gallbladder promoting altogether, minister with Rhizoma Cyperi, the Radix Aucklandiae, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae Viride, Fructus Aurantii (parched) dispersing the stagnated live-QI to relieve the stagnation of QI, therapeutic method to keep the adverse QI flowing downwards intestinal stasis relieving; Radix Astragali Preparata, Rhizoma Atractylodis Macrocephalae (parched), Poria, Fructus Citri Sarcodactylis, Fructus Chaenomelis, Pericarpium Arecae invigorating the spleen and benefiting QI, dispelling dampness and promoting diuresis, with the emerging merit that The spleen has the function to transport and transform nutrients, the monarch and his subjects' compatibility strengthening vital QI to eliminate pathogenic factors, having disappears benefit; Help with the Radix Paeoniae Alba, Rhizoma Corydalis, Fructus Forsythiae blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing and eliminating stagnation, Cortex Moutan, Rhizoma Imperatae drop-down fire are inverse, the fire second of the three ten-day periods of the hot season of dehematizing; More help with the warm blood vessels of Cortex Cinnamomi, Tuoli tonify deficiency, a surname leads all medicines, make with Radix Glycyrrhizae ridging and in, and coordinating the actions of various ingredients in a prescription.
Comprehensive all medicines are reinforcement and elimination in combination, the agent of using medicines of both cold and hot natures simultaneously, for gathering Gu Zhang mass in the abdomen, have the merit of strengthening vital QI to eliminate pathogenic factors, activating QI eliminating stagnation, the QI and blood that passes unimpeded, diuretic damp eliminating, mass in the abdomen internal diabetes in fact, for treating effective prescription of liver cirrhosis.
Iuba Equi plays the effect of guiding drug in the present invention, the property of medicine of each Chinese medicine can be fully played, promote therapeutic effect, through experiment, in this Chinese medicine, do not add Iuba Equi compared with interpolation Iuba Equi, do not add the obtained Chinese medicine of Iuba Equi, its drug effect is significantly lower than the present invention, the present invention is after interpolation Iuba Equi, and the therapeutic effect of Chinese medicine has had significant lifting.
The present invention is based on clinical practice, the each composition of above Chinese medicine is through rational compatibility, through synergism between each Chinese medicine, reinforcement and elimination in combination, having in profit, invigorating middle warmer has loose, through clinical trial, the present invention has good curative effect to treatment liver cirrhosis disease, can effectively eliminate or improve clinical symptoms and the pathological change of liver cirrhosis; And obviously have no side effect, do not develop immunity to drugs.
Each course for the treatment of is 80 days, and after taking 1 to 2 courses for the treatment of, symptom can obviously be improved, and effective percentage reaches 88%, and after curing, effect is better, does not recur.
And honeyed pill is soft and moist, drug effect is gentle, and the efficacy of a drug is lasting, and be convenient to preserve the property of medicine, taking convenience, is beneficial to and carries, and is convenient to storage, exempts Chinese medicine and decocts medicinal herbs loaded down with trivial details, difficult clothes of bitter in the mouth, the deficiency that should not be long placed in.
Compared with application Western medicine, be better than Western medicine, take stopgap measures and effect a permanent cure, evident in efficacy, delay disease process, and less to the zest of stomach, turn round and look at and protect gastric qi, alleviate body burden.
Below in conjunction with detailed description of the invention, technical scheme of the present invention is described further.
Detailed description of the invention
Embodiment, gets the crude drug composition of following weight: Radix Curcumae 180g, Herba Artemisiae Scopariae 300g, Radix Aucklandiae 120g, Pericarpium Citri Reticulatae Viride 120g, Rhizoma Cyperi 120g, Fructus Citri Sarcodactylis 120g, Fructus Aurantii (parched) 120g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Astragali Preparata 120g, Poria 300g, Fructus Chaenomelis 180g, Pericarpium Arecae 180g, Radix Paeoniae Alba 150g, Cortex Moutan 90g, Rhizoma Imperatae 300g, Rhizoma Corydalis 120g, Cortex Cinnamomi 90g, Fructus Forsythiae 200g, Radix Glycyrrhizae Preparata 60g; 20 grams, Iuba Equi.
By Chinese medicine dryness in the sun; Pulverizing, by the Radix Curcumae of above-mentioned weight, Herba Artemisiae Scopariae, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Aurantii (parched), Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Preparata, Poria, Fructus Chaenomelis, Pericarpium Arecae, the Radix Paeoniae Alba, Cortex Moutan, Rhizoma Imperatae, Rhizoma Corydalis, Cortex Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae Preparata, pulverize, obtain the order number of medicamental pulverata A, medicamental pulverata A at 80-160 order.
The Iuba Equi of above-mentioned weight is burnt till carbon shape, wears into fine powder and obtain fine powder B; By medicamental pulverata A and fine powder B mix homogeneously, obtain medicated powder.
Refined honey: choose the high-quality Mel without impurity such as offscum, dead honeybees, add appropriate clear water, mulse total amount is no more than 1/3 of pot, in case excessive during heating, heated and boiled; Be heated to 116 ~ 118 DEG C, in panful, occur the goods of even faint yellow thin bubble, obtained refined honey; Obtained refined honey water content is 10 ~ 13%.
Close medicine: mixed with the ratio of medicated powder in 1:1 by the refined honey refined, stir, when refined honey and medicated powder mixing, the temperature of refined honey controls at 116 ~ 118 DEG C, leaves standstill 6-14 minute, then make pill after stirring.
Iuba Equi plays the effect of guiding drug in the present invention, the property of medicine of each Chinese medicine can be fully played, promote therapeutic effect, through experiment, in this Chinese medicine, do not add Iuba Equi compared with interpolation Iuba Equi, do not add the obtained Chinese medicine of Iuba Equi, its drug effect is significantly lower than the present invention, the present invention is after interpolation Iuba Equi, and the therapeutic effect of Chinese medicine has had significant lifting.
Through experiment, when refined honey and medicated powder mixing, the temperature of refined honey controls at 116 ~ 118 DEG C, and the drug effect of various medicine can fully play, with compared with other temperature mixing, during mixing, the temperature of refined honey is at 116 ~ 118 DEG C, obtained medicine, and its curative effect mixes than at other temperature, drug effect has significant lifting, temperature is high again, affects the property of medicine, and temperature is low again, then the property of medicine of medicine plays not exclusively.
Through experiment, when obtained refined honey water content is 10 ~ 13%, more easily mix with medicated powder, and the rear pill obtained of mixing, the holding time is long, can the effectively property of medicine of prolong drug and the time of preservation.
Through experiment, when refined honey carries out mixing latter standing 10 minutes in the ratio of 1:1 with medicated powder, the therapeutic effect of obtained medicine is better than other time of repose; Leave standstill that medicated powder within 10 minutes, can be made mix with honey component is moist, and get final product rubbing pill after producing certain viscosity, facilitate the effective ingredient of medicine to mix fully with refined honey.
During pill, first medicine agglomerate is weighed, so that point accurate measurement, namely calculate by the total amount of the number and every ball of making pill needed for each, take agglomerate rubbing again by amount of calculation, make the pill of desired number, the function word rubbing ball bar with the hands can be determined according to pellet sizes, ball bar is divided into segment after rubbing with the hands again, then round globulate, makes the honeyed pill of beans size.
For investigating clinical efficacy and the safety of the present embodiment Chinese medicine further, the treatment curative effect of case to Chinese medicine of the present invention that we have selected 128 routine liver cirrhosis carries out clinical trial.
128 routine cases are divided into two groups at random, often organize 64 examples, the age, two groups of cases through statistical analysis, had comparability in sex, age, the course of disease etc. between 18 ~ 65 years old.
Matched group adopts rational diet, adopts that traditional Western medicine protects the liver, diuresis is treated; The oral Chinese medicine of the present invention for the treatment of group, divides and takes night and morning, take 2 courses for the treatment of.
Criterion of therapeutical effect:
1, effective: after terminating the course for the treatment of, (1) symptom, sign disappear or substantially disappear; Ascites person's ascites is had to disappear.(2) liver function recovery is normal.(3) portal vein width reduces by 0.3 ~ 0.5cm before comparatively treating, and thickness of spleen is retracted beyond 0.5cm.
2, effective: after terminating the course for the treatment of, (1) symptom, sign classification reduce more than 1 grade, but do not disappear; Ascites person's ascites is had to alleviate more than 50% and do not disappear completely.(2) liver function index fall is completely abnormal more than 50%.(3) portal vein width reduces by 0.1 ~ 0.2cm before comparatively treating, thickness of spleen retraction 0.3 ~ 0.5cm.
3, invalid: not reach above-mentioned standard or add severe one.
Curative effect comparision result after two groups of case treatments is as table one:
Table one
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 64 | 36 | 20 | 8 | 87.50 |
| Matched group | 64 | 23 | 21 | 20 | 68.75 |
By above-mentioned contrast, can find out and use the present invention to treat the obvious effective rate of liver cirrhosis disease higher than the matched group adopting Western medicine, effective number of cases and matched group about the same, but adopt Chinese medicine of the present invention compared with application Western medicine, total effective rate is given prominence to, and treatment by Chinese herbs liver cirrhosis disease of the present invention is without obvious toxic-side effects, can not cause larger burden to human body.
Liver cirrhosis is the stage that hepatic disease develops into whole latter stage, there is no specific short and Chinese medicine at present to primary disease.It is give dispenser on rationally dialectical basis that the present invention treats liver cirrhosis, and long-term taking does not find obvious toxicity, side effect, without Drug resistance, is adapted at promoting the use of clinically.
Model case:
Permitted certain, man, 38 years old, suffering from liver cirrhosis, weak for a long time, loss of appetite, abdominal distention is uncomfortable, feel sick, upper abdomen dull pain, mild diarrhea etc., suffers from liver cirrhosis through making a definite diagnosis, and after taking 2 courses for the treatment of of medicine obtained by the present embodiment, patients symptomatic disappears, recovery from illness.
Lu, female, 45 years old, suffering from liver cirrhosis, obvious time movable, lip had cyanosis, drumstick finger, and with low grade fever, liver is uncomfortable, is diagnosed as liver cirrhosis, and after taking 3 courses for the treatment of of medicine obtained by the present embodiment 2, patients symptomatic disappears, recovery from illness.
Claims (1)
1. treat a Chinese medicine for liver cirrhosis, it is characterized in that: be made up of the crude drug of following weight: Radix Curcumae 180g, Herba Artemisiae Scopariae 300g, Radix Aucklandiae 120g, Pericarpium Citri Reticulatae Viride 120g, Rhizoma Cyperi 120g, Fructus Citri Sarcodactylis 120g, Fructus Aurantii (parched) 120g, Rhizoma Atractylodis Macrocephalae (parched) 300g, Radix Astragali Preparata 120g, Poria 300g, Fructus Chaenomelis 180g, Pericarpium Arecae 180g, Radix Paeoniae Alba 150g, Cortex Moutan 90g, Rhizoma Imperatae 300g, Rhizoma Corydalis 120g, Cortex Cinnamomi 90g, Fructus Forsythiae 200g, Radix Glycyrrhizae Preparata 60g; 20 grams, Iuba Equi;
The preparation method of the Chinese medicine of this treatment liver cirrhosis, comprises the following steps:
1), for medicine, according to above-mentioned weight, Chinese medicine is assorted;
2), pulverizing, by the Radix Curcumae of above-mentioned weight, Herba Artemisiae Scopariae, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Aurantii (parched), Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Preparata, Poria, Fructus Chaenomelis, Pericarpium Arecae, the Radix Paeoniae Alba, Cortex Moutan, Rhizoma Imperatae, Rhizoma Corydalis, Cortex Cinnamomi, Fructus Forsythiae, Radix Glycyrrhizae Preparata, pulverize, obtain medicamental pulverata A;
3), by the Iuba Equi of above-mentioned weight burn till carbon shape, wear into fine powder and obtain fine powder B;
4), by medicamental pulverata A and fine powder B mix homogeneously, medicated powder is obtained;
5), refined honey: choose the high-quality Mel without impurity such as offscum, dead honeybees, add appropriate clear water, mulse total amount is no more than 1/3 of pot, in case excessive during heating, heated and boiled; Be heated to 116 ~ 118 DEG C, in panful, occur the goods of even faint yellow thin bubble, obtained refined honey;
6), close medicine: mixed with the ratio of medicated powder in 1:1 by the refined honey refined, stir, leave standstill 6-14 minute after stirring, then make pill.
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| CN104138574A (en) * | 2014-07-21 | 2014-11-12 | 济南环太机电技术有限公司 | Traditional Chinese medicine decoction for treating tympanites of infants |
| CN104623570A (en) * | 2015-03-17 | 2015-05-20 | 龚灿锋 | Traditional Chinese medicine for treating liver cirrhosis |
| CN106075144A (en) * | 2016-07-27 | 2016-11-09 | 张志杰 | A kind of Chinese medicine composition treating liver cirrhosis |
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| CN1256141C (en) * | 2004-04-23 | 2006-05-17 | 丁佐辉 | Medicine for treating liver cirrhosis |
| CN101185747A (en) * | 2007-10-17 | 2008-05-28 | 门连社 | Prescription for treating hepatic disease |
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