CN104547783A - Traditional Chinese medicine composite for treating chronic eczema, and preparation method of traditional Chinese medicine composite - Google Patents

Traditional Chinese medicine composite for treating chronic eczema, and preparation method of traditional Chinese medicine composite Download PDF

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CN104547783A
CN104547783A CN201310498785.5A CN201310498785A CN104547783A CN 104547783 A CN104547783 A CN 104547783A CN 201310498785 A CN201310498785 A CN 201310498785A CN 104547783 A CN104547783 A CN 104547783A
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radix
chinese medicine
chronic eczema
traditional chinese
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孙丰卿
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Abstract

The invention relates to a traditional Chinese medicine composite for treating chronic eczema, and a preparation method of the traditional Chinese medicine composite. The preparation method comprises the steps of crushing and mixing the following raw materials in parts by weight: 5-15 parts of cortex moutan, 25-35 parts of lithospermum erythrorhizon, 15-25 parts of salvia miltiorrhiza, 5-15 parts of periostracum cicada, 5-15 parts of bombyx batryticatus, 15-25 parts of schizonepeta, 15-25 parts of radix saposhnikoviae, 10-20 parts of folium isatidis, 6-10 parts of radix sophorae flavescentis, 5-15 parts of fructus kochiae, 25-35 parts of tribulus terrestris, 25-35 parts of cortex dictamni, 25-35 parts of rhizoma smilacis glabrae, 15-25 parts of poria cocos and 2-4 parts of scorpion, adding 5-6 times of 75% alcohol to flow back for 1-2h, performing filtering, taking a filtrate, allowing a filter residue to flow back for 2-3 times, merging the filtrate, recovering the alcohol, condensing the alcohol into a thick extract with relative density of 1.21-1.25 (measured at 80 DEG C), drying moisture, grinding obtained medicine powder, and then preparing the medicine powder into a pill, a tablet, a granule, a capsule or powder according to the prior art.

Description

A kind of Chinese medicine composition of chronic eczema and the preparation method of preparation thereof
Technical field
The present invention relates to a kind of Chinese medicine composition of chronic eczema and the preparation method of preparation thereof, belong to tcm field.
Background technology
Eczema (eczema) be by the inside and outside factor of Various Complex cause a kind of there is pleomorphism skin lesion and easily have ooze out tendency dermal inflammatory react.Primary disease cause of disease complexity is difficult to determine more.Subjective symptoms acute pruritus.The state of an illness easily repeatedly, can be delayed and not heal for many years.Chronic eczema is not often more changed by acute, subacute eczema recurrent exerbation; Also can start not obvious, because often scratching, rubbing or other stimulations, so that be chronic eczema when morbidity starts.The course of disease is chronic, is several months or several years, also can the acute attack because of stimulation, and chronic eczema is more obstinate.Chronic eczema its show as illing skin and infiltrate plump, rough surface, in kermesinus or companion's pigmentation, skin lesion mostly is limitation speckle, is common in the places such as brothers, shank, the fossa cubitalis, breast, pudendum, anus, clear-cut margin.
The morbidity of eczema, thinks a kind of Tardive allergy caused because the internal and external factor of complexity excites at present.Eczema patient allergic constitution often, this allergic constitution is relevant with inherited genetic factors, therefore falls ill in specific crowd.Chronic eczema refers to often because acute, subacute eczema recurrent exerbation more two does not transfer chronic eczema to; Also can start not obvious, because often scratching, rubbing or other stimulations, so that be chronic eczema when morbidity starts.It shows as illing skin and infiltrates plump, rough surface, and in kermesinus or companion's pigmentation, skin lesion mostly is limitation speckle, is common in the places such as brothers, shank, the fossa cubitalis, breast, pudendum, anus, clear-cut margin.The course of disease is chronic, is several months or several years, also can the acute attack because of stimulation.
The current doctor trained in Western medicine for the treatment of of primary disease there is no specific short.Generally can only to the efficient corticosteroid ointment package in local.Can with corticosteroid hormone as prednisone to small pieces skin lesion.Injection in the skin lesion such as omcilon, can be antipruritic.Or with liquid nitrogen freezing, can alleviate.Avoid long period or short-term heavy dose of external corticosteroids medicine, current Chinese medicine overcomes this drawback, and treatment safety thoroughly, has broad prospects as far as possible, and feature is application theory of Chinese medical science compatibe drug, and for cause of disease onset, and curative effect certainly.
Summary of the invention
For above deficiency, the invention provides a kind of Chinese medicine composition of chronic eczema and the preparation method of preparation thereof.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine composition for chronic eczema, be made up of following medical material:
Cortex Moutan 5-15 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Radix Salviae Miltiorrhizae 15-25 part, Periostracum Cicadae 5-15 part, Bombyx Batryticatus 5-15 part, Herba Schizonepetae 15-25 part, Radix Saposhnikoviae 15-25 part, Folium Isatidis 10-20 part, Radix Sophorae Flavescentis 6-10 part, Fructus Kochiae 5-15 part, Fructus Tribuli 25-35 part, Cortex Dictamni 25-35 part, Rhizoma Smilacis Glabrae 25-35 part, Poria 15-25 part, Scorpio 2-4 part.
As technique scheme further preferably, described Chinese medicine composition is made up of following medical material:
Cortex Moutan 10 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Radix Salviae Miltiorrhizae 20 parts, Periostracum Cicadae 10 parts, Bombyx Batryticatus 10 parts, Herba Schizonepetae 20 parts, Radix Saposhnikoviae 20 parts, Folium Isatidis 15 parts, Radix Sophorae Flavescentis 8 parts, the Fructus Kochiae 10 parts, Fructus Tribuli 30 parts, Cortex Dictamni 30 parts, Rhizoma Smilacis Glabrae 30 parts, 20 parts, Poria, Scorpio 3 parts.
Chinese medicine composition pharmaceutical preparation of the present invention is one of following dosage forms: water decoction, pill, tablet, granule, capsule or powder.Make by prior art.
A preparation method for the Chinese medicine composition pharmaceutical preparation of chronic eczema, comprises the following steps:
A, proportionally get each composition of raw material mixing, decoct with water 30 minutes water decoction.
B, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Salviae Miltiorrhizae, Periostracum Cicadae, Bombyx Batryticatus, Herba Schizonepetae, Radix Saposhnikoviae, Folium Isatidis, Radix Sophorae Flavescentis, the Fructus Kochiae, Fructus Tribuli, Cortex Dictamni, Rhizoma Smilacis Glabrae, Poria, Scorpio to be pulverized respectively, mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeats backflow 2-3 time, merging filtrate; Reclaim ethanol.
C, the filtrate of above-mentioned steps b is condensed into the thick extractum of relative density 1.21 ~ 1.25 (80 DEG C record), obtains unguentum.
D, by the unguentum shift-in baking oven of step c gained, dry to moisture lower than 5% for 50-70 DEG C, add applicable adjuvant after the grinding of the medicated powder that obtains, make pill, tablet, granule, capsule or powder by prior art.
In above raw material,
Cortex Moutan has and purifies the blood, the function of promoting blood circulation to remove blood stasis.Cure mainly macule to spit blood, amenorrhea due to stagnation of blood, premenstrual gesture, carbuncle sore tumefacting virus, traumatic blood stasis, the deficiency of YIN, send out gesture, without juice hectic fever due to YIN-deficiency.
Radix Arnebiae (Radix Lithospermi) cures mainly: removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.
Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, relieving restlessness is calmed the nerves, reducing swelling and alleviating pain.The detumescence of function blood circulation promoting and blood stasis dispelling, removing heat from blood, clear away heart-fire the effects such as relieving restlessness, is mainly applicable to the stagnant menoxenia of the heat in blood stasis of blood, amenorrhea dysmenorrhea, abdominal mass and postpartum stagnation, lochiorrhea, few abdomen have a pain.
Periostracum Cicadae falls apart wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Bombyx Batryticatus can cure mainly expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, submandibular lymph nodes is scorching, facial paralysis, skin pruritus.
Herba Schizonepetae function is delivered, and dispels the wind, treating blood disorders; Parch to black stops blooding.Cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool; Metrorrhagia, puerperal blood faints; Carbuncle, skin ulcer scabies, scrofula.
Radix Saposhnikoviae has expelling pathogenic wind from the body surface, removing damp and stopping pain, soothing the liver spasmolytic, effect of killing parasites for relieving itching; Cure mainly affection of exogenous wind-cold, headache stiffness of the nape, dizzy dusk is puckery, anemofrigid-damp arthralgia, and joint is ached, and stomachache is had loose bowels, discharging fresh blood stool, broken damaging the spleen and stomach wind, and measles is thoroughly difficult, rubella pruritus, skin infection from the beginning of.
Folium Isatidis heat-clearing and toxic substances removing; Blood cooling and ecchymoses removing, generates heat for epidemic febrile disease; Send out speckle dermexanthesis; Dyspnea and cough due to lung-heat, hematemesis and epistaxis; Sore throat; Hematodiarrhoea; Jaundice; Mumps; Erysipelas; Aphtha; Carbuncle.
Radix Sophorae Flavescentis heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Fructus Kochiae effect diuresis, clearing away damp-heat.Cure mainly dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.
Fructus Tribuli falls apart wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, promoting the circulation of blood.Control headache, itching over the body, conjunctival congestion swells nebula, fullness in the chest, cough with dyspnea, lump in the abdomen, and breast is difficult, carbuncle, scrofula.Suppressing the hyperactive liver; Resolving depression; Dispelling pathogenic wind for improving eyesight.Main headache; Dizzy; Distending pain in the chest and hypochondrium; Distending pain of the breast; Breast closes obstructed; Amenorrhea; Cataract; Rubella pruritus; Vitiligo; Skin ulcer cellulitis; Scrofula.
Cortex Dictamni effect heat clearing and damp drying, removing toxic substances of dispeling the wind.Cure mainly damp and hot sore, eczema scabies, jaundice dark coloured urine, damp and hot arthralgia pain.
Rhizoma Smilacis Glabrae removing toxic substances, diuresis, antipyretic, clean blood.Control chronic skin infection, dermatosis, syphilis and sequela thereof, dysentery.
Poria function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For irritability, palpitation with fear insomnia, edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, has loose bowels in loose stool.
Scorpio function with cure mainly endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Control infantile convulsion to take out and pluck, epilepsy, apoplexy, hemiplegia, facial hemiparalysis, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer swells, skin infection, scrofula.
The chronic eczema traditional Chinese medical science, because taste are impaired, loses its strong fortune, damp and hot interior life, and hold concurrently again outer by ailment said due to cold or exposure, inside and outside two heresies are won mutually, caused by rheumatism pathogenic heat contamination skin, the sick impairment of YIN of consumption for a long time blood more than adding, blood-deficiency and wind-dry, and even squamous and dry skin, passages through which vital energy circulates is slow, and QI-blood circulation is smooth, damp and hotly accumulates resistance, caused by skin losing its nutrition.The present invention's Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, cooling blood and dissolving purpura, Periostracum Cicadae, Bombyx Batryticatus, Herba Schizonepetae, Radix Saposhnikoviae, Scorpio, Poria fall apart wind heat extraction, drive away all rheumatism inside and outside, Folium Isatidis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Radix Sophorae Flavescentis, Fructus Kochiae heat clearing and damp drying, make damp go out from urine, and Fructus Tribuli is loose is in fashion blood, and Cortex Dictamni, Rhizoma Smilacis Glabrae heat clearing and damp drying are dispeled the wind, clean blood removing toxic substances.
The present invention compared with prior art, has the following advantages: the present invention is directed to the cause of disease and nurse one's health comprehensively, and have medication instant effect, side effect is little, can reach inside and outside and execute, the object of giving consideration to both the incidental and fundamental.Can suppress the development of the state of an illness, level before skin is replied, and obviously can shorten the course of disease, therapeutic effect is obvious, is worthy of popularization.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
A Chinese medicine composition for chronic eczema, Cortex Moutan 10 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Radix Salviae Miltiorrhizae 20 parts, Periostracum Cicadae 10 parts, Bombyx Batryticatus 10 parts, Herba Schizonepetae 20 parts, Radix Saposhnikoviae 20 parts, Folium Isatidis 15 parts, Radix Sophorae Flavescentis 8 parts, the Fructus Kochiae 10 parts, Fructus Tribuli 30 parts, Cortex Dictamni 30 parts, Rhizoma Smilacis Glabrae 30 parts, 20 parts, Poria, Scorpio 3 parts.
Preparation method:
A, proportionally get each composition of raw material mixing, decoct with water 30 minutes water decoction.
B, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Salviae Miltiorrhizae, Periostracum Cicadae, Bombyx Batryticatus, Herba Schizonepetae, Radix Saposhnikoviae, Folium Isatidis, Radix Sophorae Flavescentis, the Fructus Kochiae, Fructus Tribuli, Cortex Dictamni, Rhizoma Smilacis Glabrae, Poria, Scorpio to be pulverized respectively, mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeats backflow 2-3 time, merging filtrate; Reclaim ethanol.
C, the filtrate of above-mentioned steps b is condensed into the thick extractum of relative density 1.21 ~ 1.25 (80 DEG C record), obtains unguentum.
D, by the unguentum shift-in baking oven of step c gained, dry to moisture lower than 5% for 50-70 DEG C, add applicable adjuvant after the grinding of the medicated powder that obtains, make pill, tablet, granule, capsule or powder by prior art.
Embodiment 2:
A Chinese medicine composition for chronic eczema, described medicine is made up of following medical material: Cortex Moutan 5 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, Radix Salviae Miltiorrhizae 15 parts, Periostracum Cicadae 5 parts, Bombyx Batryticatus 5 parts, Herba Schizonepetae 15 parts, Radix Saposhnikoviae 15 parts, Folium Isatidis 10 parts, Radix Sophorae Flavescentis 6 parts, the Fructus Kochiae 5 parts, Fructus Tribuli 25 parts, Cortex Dictamni 25 parts, Rhizoma Smilacis Glabrae 25 parts, 15 parts, Poria, Scorpio 2 parts.
Preparation method is with embodiment 1.
Embodiment 3:
A Chinese medicine composition for chronic eczema, described medicine is made up of following medical material: Cortex Moutan 15 parts, Radix Arnebiae (Radix Lithospermi) 35 parts, Radix Salviae Miltiorrhizae 25 parts, Periostracum Cicadae 15 parts, Bombyx Batryticatus 15 parts, Herba Schizonepetae 25 parts, Radix Saposhnikoviae 25 parts, Folium Isatidis 20 parts, Radix Sophorae Flavescentis 10 parts, the Fructus Kochiae 15 parts, Fructus Tribuli 35 parts, Cortex Dictamni 35 parts, Rhizoma Smilacis Glabrae 35 parts, 25 parts, Poria, Scorpio 4 parts.
Preparation method is with embodiment 1.
Contrast test: criterion of therapeutical effect: efficacy evaluation is cured according to " TCM Dermatology disease Standardization of diagnosis and curative effect ": skin lesion disappears.Take a turn for the better: skin lesion disappears more than 30%.Do not heal: skin lesion disappears less than 30%.
Choose 400 routine patients with chronic eczema, random selecting 300 example is as treatment group, other 100 examples as a control group, wherein 300 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3,100 routine patients of each treatment group treatment random selecting, the decoction that treatment group 1 uses the embodiment of the present invention 1 to prepare is treated, and the decoction that treatment group 2 uses the embodiment of the present invention 2 to prepare is treated, the decoction that treatment group 3 uses the embodiment of the present invention 3 to prepare is treated, and within 15 days, is a course for the treatment of.
The patient of matched group adopts Cyproheptadine to coordinate vitamin C, prednisone oral medication.
Therapeutic outcome is as following table:
Contrast group Cure Take a turn for the better (example) Invalid (example) Cure rate Effective percentage
Treatment group 1 89 9 2 89％ 98％
Treatment group 2 76 18 6 76％ 94％
Treatment group 3 86 10 4 86％ 96％
Matched group 45 32 23 45％ 77％
As can be seen from above tables of data, treatment group effective percentage cure rate is apparently higher than matched group, and the cure rate effective percentage for the treatment of group 1 is higher than all the other treatment groups 2 and treatment group 3, and treatment group 1 prescription is the most effective in sum.

Claims (4)

1. a Chinese medicine composition for chronic eczema, is characterized in that: be made up of the raw material of following weight portion: Cortex Moutan 5-15 part, Radix Arnebiae (Radix Lithospermi) 25-35 part, Radix Salviae Miltiorrhizae 15-25 part, Periostracum Cicadae 5-15 part, Bombyx Batryticatus 5-15 part, Herba Schizonepetae 15-25 part, Radix Saposhnikoviae 15-25 part, Folium Isatidis 10-20 part, Radix Sophorae Flavescentis 6-10 part, Fructus Kochiae 5-15 part, Fructus Tribuli 25-35 part, Cortex Dictamni 25-35 part, Rhizoma Smilacis Glabrae 25-35 part, Poria 15-25 part, Scorpio 2-4 part.
2. the Chinese medicine composition of a kind of chronic eczema as claimed in claim 1, is characterized in that: by following weight portion raw material make: Cortex Moutan 10 parts, Radix Arnebiae (Radix Lithospermi) 30 parts, Radix Salviae Miltiorrhizae 20 parts, Periostracum Cicadae 10 parts, Bombyx Batryticatus 10 parts, Herba Schizonepetae 20 parts, Radix Saposhnikoviae 20 parts, Folium Isatidis 15 parts, Radix Sophorae Flavescentis 8 parts, the Fructus Kochiae 10 parts, Fructus Tribuli 30 parts, Cortex Dictamni 30 parts, Rhizoma Smilacis Glabrae 30 parts, 20 parts, Poria, Scorpio 3 parts.
3. the Chinese medicine composition of chronic eczema as claimed in claim 1 or 2, is characterized in that: described pharmaceutical dosage form is: water decoction, pill, tablet, granule, capsule or powder.
4. a preparation method for the Chinese medicine composition of the chronic eczema described in claim 1 or 2, comprises the following steps:
A, proportionally get each composition of raw material mixing, decoct with water 30 minutes water decoction.
B, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Salviae Miltiorrhizae, Periostracum Cicadae, Bombyx Batryticatus, Herba Schizonepetae, Radix Saposhnikoviae, Folium Isatidis, Radix Sophorae Flavescentis, the Fructus Kochiae, Fructus Tribuli, Cortex Dictamni, Rhizoma Smilacis Glabrae, Poria, Scorpio to be pulverized respectively, mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeats backflow 2-3 time, merging filtrate; Reclaim ethanol.
C, the filtrate of above-mentioned steps b is condensed into the thick extractum of relative density 1.21 ~ 1.25 (80 DEG C record), obtains unguentum.
D, by the unguentum shift-in baking oven of step c gained, dry to moisture lower than 5% for 50-70 DEG C, add applicable adjuvant after the grinding of the medicated powder that obtains, make pill, tablet, granule, capsule or powder by prior art.
CN201310498785.5A 2013-10-23 2013-10-23 Traditional Chinese medicine composite for treating chronic eczema, and preparation method of traditional Chinese medicine composite Withdrawn CN104547783A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105169342A (en) * 2015-10-12 2015-12-23 临沂草之美医药科技有限公司 Traditional Chinese medicine composition for treating eczema and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105169342A (en) * 2015-10-12 2015-12-23 临沂草之美医药科技有限公司 Traditional Chinese medicine composition for treating eczema and preparation method thereof

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Application publication date: 20150429