CN113679771A

CN113679771A - Traditional Chinese medicine composition for treating dermatitis and preparation method thereof

Info

Publication number: CN113679771A
Application number: CN202111198355.2A
Authority: CN
Inventors: 吕向东
Original assignee: Zhejiang Yanghe Health Management Technology Co ltd
Current assignee: Zhejiang Yanghe Health Management Technology Co ltd
Priority date: 2021-10-14
Filing date: 2021-10-14
Publication date: 2021-11-23

Abstract

The invention provides a traditional Chinese medicine composition for treating dermatitis and a preparation method thereof, and relates to the technical field of medicines for treating dermatitis. The traditional Chinese medicine composition for treating dermatitis comprises the following raw materials in parts by weight: 10-15 parts of fructus forsythiae, 15-20 parts of houttuynia cordata, 9-12 parts of raw sanguisorba officinalis, 5-8 parts of radix sophorae flavescentis, 5-8 parts of cortex dictamni, 8-12 parts of honeysuckle, 9-12 parts of astragalus membranaceus, 9-12 parts of angelica sinensis, 6-10 parts of rhizoma alismatis, 5-8 parts of fructus cnidii and 5-10 parts of liquorice, has the effects of resisting inflammation, resisting bacteria, relieving itching and the like, has a good immunoregulation effect, can improve the immunity of an organism, enables the disordered immune state of the organism to be recovered to be normal, thereby effectively resisting dermatitis, and has remarkable curative effect and small side effect. The invention also provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which can improve the extraction rate of the medicine and the curative effect of the medicine, and the ointment-shaped medicine is convenient to carry and smear and has strong practicability.

Description

Traditional Chinese medicine composition for treating dermatitis and preparation method thereof

Technical Field

The invention relates to the technical field of medicines for treating dermatitis, and particularly relates to a traditional Chinese medicine composition for treating dermatitis and a preparation method thereof.

Background

Dermatitis generally refers to various types of skin inflammation, is the most common disease in dermatology, has complex and various causes, and is related to allergy, heredity, immunity, infection, medicaments, insect bites, physical factors and the like. The clinical manifestations are various, the skin lesions are polymorphic, including papules, blisters, erythema, scales, erosion, ulcers, etc., and patients may also suffer from itching, burning, pain, etc. The treatment is usually carried out by selecting medicines, operations, physical methods and the like according to specific conditions. Glucocorticoids, antihistamines and immunosuppressants are conventional medicaments for clinically treating atopic dermatitis, but the medicaments cannot radically treat the dermatitis, have large side effect and high recurrence rate after long-term use and are not easily accepted by patients. Therefore, it is very important to develop a traditional Chinese medicine composition for treating dermatitis, which has the advantages of obvious curative effect, small side effect, simplicity, convenience and practicability.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating dermatitis, which has anti-inflammatory and antibacterial effects, active substances in the medicine can remove dampness and relieve itching, has good immunoregulation effect, can improve the immunity of an organism, and enables the disordered immune state of the organism to be recovered to be normal, so that the dermatitis is effectively resisted, and the traditional Chinese medicine composition has a remarkable curative effect and small side effect.

The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating dermatitis, which is simple to operate, can realize large-scale mass production, can improve the extraction rate of the medicine and the curative effect of the medicine, is convenient to carry and smear the paste-shaped medicine, and has strong practicability.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

The invention provides a traditional Chinese medicine composition for treating dermatitis, which comprises the following raw materials in parts by weight: 10-15 parts of fructus forsythiae, 15-20 parts of houttuynia cordata, 9-12 parts of raw sanguisorba officinalis, 5-8 parts of radix sophorae flavescentis, 5-8 parts of cortex dictamni, 8-12 parts of honeysuckle, 9-12 parts of astragalus membranaceus, 9-12 parts of angelica sinensis, 6-10 parts of rhizoma alismatis, 5-8 parts of fructus cnidii and 5-10 parts of liquorice.

The invention provides a preparation method of a traditional Chinese medicine composition for treating dermatitis, which comprises the following steps: adding ethanol into the raw materials, grinding for 10-15 minutes, then carrying out ultrasonic treatment at 30-45 ℃ for 1-2 hours, standing for 3-4 hours, centrifuging to obtain a supernatant, carrying out reduced pressure distillation on the supernatant until the solid content is 50-60% to obtain a concentrated solution, adding a pharmaceutical adjuvant into the concentrated solution, and mixing to obtain the traditional Chinese medicine composition for treating dermatitis, wherein the mass ratio of the concentrated solution to the pharmaceutical adjuvant is 1 (1-1.5).

The traditional Chinese medicine composition for treating dermatitis and the preparation method thereof provided by the invention have at least the following beneficial effects:

on one hand, the compatibility of the components of the traditional Chinese medicine composition for treating dermatitis provided by the invention is reasonable, and the fructus forsythiae and the herba houttuyniae are combined to achieve the effects of clearing away heat and toxic materials, dissipating blood stasis and reducing swelling, and are monarch drugs. The ministerial drugs comprise raw sanguisorba, radix sophorae flavescentis, cortex dictamni, honeysuckle, radix astragali and angelica sinensis, wherein the raw sanguisorba can heal sores and detoxify and cool blood to stop bleeding; the sophora flavescens and the cortex dictamni clear heat and dry dampness, kill parasites and relieve itching; honeysuckle flower has the effects of clearing away heat and toxic materials and dispelling wind and heat; radix astragali has effects of invigorating qi, consolidating superficial resistance, invigorating qi, nourishing blood, inducing diuresis, and relieving swelling; angelica sinensis can nourish blood, activate blood, moisten skin, relieve itching, and relieve swelling and pain. The alisma orientale and the common cnidium fruit are used as adjuvant drugs, and the alisma orientale can excrete damp-heat with urine by being combined with the drugs for excreting dampness and draining dampness and purging heat; fructus Cnidii has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, relieving itching, and relieving anaphylaxis. Radix Glycyrrhizae Praeparata is used for regulating zhu's medicine. The whole formula has reasonable compatibility, combines the effects of eliminating and tonifying, performing the functions of dispersing and receiving, and playing the effects of clearing away heat and toxic materials, nourishing blood and promoting blood circulation, and dispelling wind and arresting itching. In addition, the medicines have the effects of resisting inflammation and bacteria, active substances in the medicines can remove dampness and relieve itching, and the medicines have good immunoregulation effect, can improve the immunity of the organism, so that the disordered immune state of the organism is recovered to be normal, and the dermatitis is effectively resisted. Moreover, the preparation of the medicament is carried out by adding ethanol, so that the medicament can promote blood circulation and promote medicinal efficacy, and the medicament can directly reach skin, hair orifices and the like, promote local or systemic blood circulation, accelerate metabolism and accelerate healing of dermatitis.

On the other hand, the invention also provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, the cell walls of the traditional Chinese medicines are destroyed in the process of adding the raw materials into ethanol for grinding, and simultaneously, the ethanol is taken as an extracting agent to be beneficial to the dissolution of the medicine components, so that the bioavailability of the raw materials is improved. Grinding for 10-15 minutes can fully grind the raw materials to increase the contact area between the raw materials and the extractant, and can fully mix the extractant and the raw materials, thereby being beneficial to the extraction of active ingredients of the medicament, saving energy and reducing production cost. Then, the slurry is subjected to ultrasonic treatment at 30-45 deg.C for 1-2 hr, under the treatment condition, not only can the activity of the medicinal component be preserved, but also the dissolution of the active component can be accelerated, thereby shortening the extraction time. Standing for 3-4 hr after ultrasonic treatment to precipitate and remove large granule residue, centrifuging, and collecting supernatant to remove light impurities in the solution, thereby purifying the medicine and enhancing the drug effect of the medicine. Distilling the supernatant under reduced pressure until the solid content is 50-60% to obtain a concentrated solution, adding pharmaceutical adjuvants into the concentrated solution, and mixing to obtain the traditional Chinese medicine composition for treating dermatitis, wherein the mass ratio of the concentrated solution to the pharmaceutical adjuvants is 1 (1-1.5). The concentrated solution and the pharmaceutic adjuvant in the proportion are mixed to obtain the ointment, the content of each component in the ointment is proper, the ointment can play the maximum pharmacodynamic action, and the side effect of an organism caused by excessive medicines is avoided.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The invention provides a traditional Chinese medicine composition for treating dermatitis, which comprises the following raw materials in parts by weight: 10-15 parts of fructus forsythiae, 15-20 parts of houttuynia cordata, 9-12 parts of raw sanguisorba officinalis, 5-8 parts of radix sophorae flavescentis, 5-8 parts of cortex dictamni, 8-12 parts of honeysuckle, 9-12 parts of astragalus membranaceus, 9-12 parts of angelica sinensis, 6-10 parts of rhizoma alismatis, 5-8 parts of fructus cnidii and 5-10 parts of liquorice. In which Lian Qiao is bitter in taste and slightly cold in nature, and enters lung, heart and small intestine meridians. It has effects of heat-clearing and detoxicating, detumescence and resolving hard mass, dispelling wind and heat, and is commonly used for treating carbuncle and cellulitis, scrofula, acute mastitis, erysipelas, early stage epidemic febrile disease, warm heat entering nutrient, hyperpyrexia and polydipsia, heat stranguria and pain. Some monomer components of fructus forsythiae, such as forsythoside, phillyrin, forsythiaside, arctiin and aglycone thereof, quercetin, isoquercitin, rutin, luteolin, alkaloid components and the like, also have anti-inflammatory effects, and the anti-inflammatory effect is achieved by regulating and controlling various signal paths to influence the release of related enzyme activity and inflammatory mediators and influence the change of related metabolites in organisms. The cordate houttuynia is pungent in flavor and slightly cold in nature, enters lung meridian, and has the effects of clearing heat and removing toxicity, eliminating carbuncle and expelling pus, inducing diuresis and treating stranguria and the like. The heartleaf houttuynia herb can dissipate blood, promote blood circulation, reduce blood pressure, dissipate blood stasis, clear away lung heat, moisten lung, dredge nasal orifices, clear heat and remove internal heat, and is beneficial to urination and detumescence; can be used for treating lung abscess, phlegm heat cough, pneumonia, edema, urethral orifice infection, carbuncle, furuncle, skin sore, suppurative otitis media, dysentery, mastitis, cellulitis, and centipede bite. The houttuynia cordata contains various microorganisms with an inhibiting effect and an antibacterial effect, and contained brass compounds such as quercetin, quercitrin and isoquercitrin have a remarkable anti-inflammatory effect and can remarkably inhibit capillary hyperfunction in the early stage of inflammation. Modern pharmacological research shows that the cordate houttuynia has a certain inhibition effect on staphylococcus aureus, staphylococcus albus, pseudomonas aeruginosa, proteus and the like, and the houttuynine sodium bisulfite has a certain diuretic effect.

The dried rehmannia root is bitter and sour in taste and slightly cold in nature, enters liver, stomach and large intestine channels, has the effects of cooling blood, stopping bleeding, detoxifying and healing sores, and is clinically used for treating various skin diseases such as eczema, dementia pox pyogenic infections, burns and scalds, skin ulceration and the like. Modern pharmacological research finds that the radix rehmanniae contains tannin and radix rehmanniae saponin. The tannin has astringent effect, can reduce and control secretion of wound surface such as burn, and has good effect of promoting wound healing. Moreover, the disaccharide compound extracted from the Chinese wolfberry can effectively inhibit the release of histamine, thereby achieving the effect of resisting allergy and relieving itching. Kuh-seng is bitter in taste and cold in nature, enters liver, stomach, dolphin and wrist meridians, has the effects of clearing heat and drying dampness, killing parasites and relieving itching, and inducing diuresis, and is commonly used for treating damp-heat sores and ulcers, pruritus vulvae and scab. The radix Sophorae Flavescentis extract can effectively inhibit the production of inflammatory cytokine, thereby inhibiting inflammatory reaction caused by various inflammatory agents. Furthermore, oxymatrine has antiallergic effect, and has inhibitory effect on mast cell histamine release caused by Ig E and its specific antigen. The cortex dictamni is bitter in taste and cold in nature, enters spleen and stomach channels, and has the effects of clearing heat and removing toxicity, and eliminating dampness and relieving itching. Modern pharmacological studies show that the cortex dictamni has the effects of resisting inflammation and bacteria, resisting tumors, protecting nerves, resisting platelet aggregation, relaxing blood vessels and the like, and is mainly used for treating damp-heat sore toxin, yellow water dripping, eczema, mange, rheumatic pyretic arthralgia, jaundice dark urine and other diseases. The cortex dictamni has inhibitory effect on cellular immunity and humoral immunity, can prevent tissue damage caused by inflammation by inhibiting the release of various inflammation mediators, inhibits hyperactive anaphylactic reaction, is beneficial to the body to recover normal immunologic function, and does not cause spleen atrophy while inhibiting immunity. In addition, the cortex dictamni extract can inhibit the combination of antigen and Ig E, thereby reducing inflammatory mediators such as histamine release of mast cells, reducing body pruritus and having a certain anti-pruritus effect.

Honeysuckle flower is sweet, cold and fragrant in nature, and can clear heat without hurting stomach if being sweet and cold, and eliminate pathogenic factors if being fragrant. Enters the channels of lung, stomach and large intestine, and has the effects of clearing away heat and toxic materials and dispelling wind and heat. The honeysuckle has excellent effect and good clinical effect, can diffuse wind heat, clear away heat and toxic materials, has the functions of broad-spectrum antibiosis, antivirus, antipyretic and anti-inflammatory, cholagogue and liver protection, lipid reduction and the like as a common traditional Chinese medicine, and is used for treating various infections, inflammations, hyperlipidemia, tumor radiotherapy and chemotherapy xerostomia, various febrile diseases and the like. Radix astragali is sweet in flavor and warm in nature, and has the effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, expelling pus, removing toxic substances and promoting granulation. Radix astragali contains various active substances such as astragaloside A, flavone, and astragalus polysaccharide, and has important effects in regulating immunity, such as enhancing immunity, resisting stress, virus, inflammation, and oxidation. Wherein, the astragalus flavonid can inhibit the generation of inflammation by inhibiting the expression of related protein; the astragaloside IV can reduce the activation of astrocytes and release more proinflammatory molecules, promote the activated astrocytes to secrete protective factors, improve the microenvironment of cell inflammation and inhibit the release of inflammatory factors, thereby achieving the purpose of resisting inflammation. The angelica sinensis is sweet and pungent in flavor and warm in nature, enters liver, heart and spleen channels, and has the effects of enriching and activating blood, regulating menstruation and relieving pain, relaxing bowel and the like. The polysaccharide, total acid and ferulic acid in radix Angelicae sinensis can enhance phagocytic function of macrophage, promote lymphocyte to generate interleukin, and increase immunity of organism. The neutral oil in the angelica can inhibit the generation of antibodies, play a role in resisting complement and promote the function of humoral immunity. The phenolic oil in the angelica has higher inhibiting effect on various bacteria such as staphylococcus aureus, escherichia coli and the like. The angelica sinensis extract has good inhibition effect on tissue edema and chronic inflammatory injury caused by an inflammatory agent, can also inhibit platelet AA metabolism and 5-HT release, has analgesic and anti-inflammatory effects and the like.

Rhizoma alismatis is sweet and light in taste and cold in nature, enters kidney and bladder channels, and has the effects of promoting diuresis and excreting dampness, clearing heat, eliminating turbid pathogen and reducing blood fat and the like. Alismatis rhizoma triterpene can inhibit inflammatory reaction by inhibiting release of inflammatory factor. And chemical derivatives of alisol can relieve idiopathic dermatitis, and has activity of inhibiting inflammatory factors. Meanwhile, the alisma orientale also has various physiological activities of reducing blood fat, reducing blood sugar, promoting urination, protecting liver, resisting tumor and the like. Fructus cnidii is pungent and bitter in taste and warm in nature, enters kidney channel, has the effects of eliminating dampness and dispelling wind, killing parasites and relieving itching, warming kidney and tonifying yang and the like, and is commonly used for treating symptoms such as pruritus vulvae, leukorrhagia, eczema, pruritus, damp arthralgia, lumbago, deficiency of the kidney and impotence and the like. Osthole is one of the main effective components of fructus Cnidii extract, and can inhibit passive skin anaphylaxis, and indirectly inhibit pruritus by inhibiting histamine release from mast cell.

The liquorice is sweet in taste and neutral in nature, and can tonify spleen and qi, relieve spasm and pain, moisten lung and relieve cough, and moderate drug properties. The Glycyrrhrizae radix total saponin can reduce the generation and release of macrophage inflammation medium to exert antiinflammatory effect. In the expression of inflammatory chemotactic factor and proinflammatory factor, glycyrrhizin can inhibit colonic myeloperoxidase, reduce lipid protein denaturation and organ injury caused by active oxidizing substances, and improve inflammatory symptoms. Glycyrrhizic acid and diammonium salt thereof can avoid oxidative stress, obviously reduce lipid oxidation, improve serum total protein level and improve antioxidant capacity. The anti-inflammatory effect of the liquorice has wide application in the aspects of reducing phlegm, relieving asthma, detoxifying, resisting bacteria, regulating immunity and the like.

The compatibility of the components is reasonable, and the fructus forsythiae and the herba houttuyniae are combined to achieve the effects of clearing away heat and toxic materials, dissipating blood stasis and reducing swelling, and are monarch drugs. The ministerial drugs comprise raw sanguisorba, radix sophorae flavescentis, cortex dictamni, honeysuckle, radix astragali and angelica sinensis, wherein the raw sanguisorba can heal sores and detoxify and cool blood to stop bleeding; the sophora flavescens and the cortex dictamni clear heat and dry dampness, kill parasites and relieve itching; honeysuckle flower has the effects of clearing away heat and toxic materials and dispelling wind and heat; radix astragali has effects of invigorating qi, consolidating superficial resistance, invigorating qi, nourishing blood, inducing diuresis, and relieving swelling; angelica sinensis can nourish blood, activate blood, moisten skin, relieve itching, and relieve swelling and pain. The alisma orientale and the common cnidium fruit are used as adjuvant drugs, and the alisma orientale can excrete damp-heat with urine by being combined with the drugs for excreting dampness and draining dampness and purging heat; fructus Cnidii has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, relieving itching, and relieving anaphylaxis. Radix Glycyrrhizae Praeparata is used for regulating zhu's medicine. The whole formula has reasonable compatibility, combines the effects of eliminating and tonifying, performing the functions of dispersing and receiving, and playing the effects of clearing away heat and toxic materials, nourishing blood and promoting blood circulation, and dispelling wind and arresting itching. In addition, the medicines have the effects of resisting inflammation and bacteria, active substances in the medicines can remove dampness and relieve itching, and the medicines have good immunoregulation effect, can improve the immunity of the organism, so that the disordered immune state of the organism is recovered to be normal, and the dermatitis is effectively resisted. Moreover, the preparation of the medicament is carried out by adding ethanol, so that the medicament can promote blood circulation and promote medicinal efficacy, and the medicament can directly reach skin, hair orifices and the like, promote local or systemic blood circulation, accelerate metabolism and accelerate healing of dermatitis.

Further, when 12 parts of fructus forsythiae, 18 parts of houttuynia cordata, 10 parts of raw sanguisorba officinalis, 6 parts of radix sophorae flavescentis, 7 parts of cortex dictamni, 10 parts of honeysuckle, 10 parts of astragalus membranaceus, 10 parts of angelica sinensis, 8 parts of rhizoma alismatis, 7 parts of fructus cnidii and 8 parts of liquorice are used, the traditional Chinese medicine composition for treating dermatitis can quickly improve allergic constitution of patients, is anti-inflammatory and repair, recovers natural physiological functions of the patients, and is remarkable in curative effect and small in side effect and adverse reaction.

In order to moisten the skin and accelerate the improvement of skin itching symptoms, 9-12 parts of cortex lycii radicis and/or 5-10 parts of bitter almond are/is added into the raw materials in parts by weight in the embodiment of the invention. Wherein, the cortex lycii radicis is sweet in taste and cold in nature, enters lung, liver and kidney channels, and has the effects of cooling blood, removing steam, clearing lung-heat and reducing internal heat. Modern pharmacological research proves that cortex lycii radicis has the effects of relieving fever, resisting bacteria and viruses, regulating immunity, easing pain and the like. The active ingredients such as flavone, anthraquinone and the like contained in the cortex lycii radicis have various skin treatment and repair effects, and have certain treatment and maintenance effects on skin injury. Moreover, the cortex lycii radicis extract can promote apoptosis and normal cell growth of damaged skin fibroblasts, and can promote synthesis of hydroxyproline in wound skin tissues, thereby accelerating healing of damaged skin. The bitter apricot seeds are bitter in taste and slightly warm in nature, enter lung and large intestine channels, and have the effects of descending qi, relieving cough and asthma, and relaxing bowel. The bitter almond oil has the effects of moisturizing and moistening skin, improving the barrier function of skin, reducing the water loss of skin and promoting the renewal and repair of epithelial cells.

In order to improve the sleep quality of dermatitis patients, the embodiment of the invention also comprises 5-10 parts of polygala tenuifolia and/or 5-10 parts of nacre by weight in addition to the medicinal raw materials. Wherein, the polygala root is bitter and pungent in taste and warm in nature, and has the effects of soothing the nerves, promoting intelligence, restoring normal coordination between heart and kidney, eliminating phlegm and reducing swelling. It is used to treat insomnia, dreaminess, amnesia, pavor, absent mindedness, expectoration, skin ulcer, and toxic swelling. Concha Margaritifera is salty in taste and cold in nature, enters liver and heart meridians, has the effects of calming liver, suppressing yang hyperactivity, tranquilizing mind, arresting convulsion, improving eyesight and removing nebula, and is commonly used for treating symptoms such as headache, dizziness, palpitation, insomnia, conjunctival congestion, nebula, blurred vision and the like.

In order to promote the medicine to penetrate through the surface layer of the skin and reach the focus, 3-6 parts by weight of mint are also added in the embodiment of the invention. The mint is pungent in flavor and cool in nature, enters lung and liver channels, and has the effects of clearing head and eyes, relieving sore throat, promoting eruption, dispelling wind and heat, soothing liver, promoting qi circulation and the like. The mint extract can not only reduce the barrier effect of the skin by increasing the fluidity of the active epidermis, but also facilitate the transdermal absorption of the medicine; can also reduce the barrier effect of skin to drugs by destroying the ordered arrangement of horny layer and horny cell, so that the drugs can penetrate into the focus of infection, thereby enhancing the curative effect. In addition, herba Menthae has antiinflammatory, antiviral, anticancer, antibacterial, antioxidant, center exciting, and radioprotective effects.

The invention also provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which comprises the following steps: adding ethanol into the raw materials, grinding for 10-15 minutes, then carrying out ultrasonic treatment at 30-45 ℃ for 1-2 hours, standing for 3-4 hours, centrifuging to obtain a supernatant, carrying out reduced pressure distillation on the supernatant until the solid content is 50-60% to obtain a concentrated solution, adding a pharmaceutical adjuvant into the concentrated solution, and mixing to obtain the traditional Chinese medicine composition for treating dermatitis, wherein the mass ratio of the concentrated solution to the pharmaceutical adjuvant is 1 (1-1.5). The method has the advantages that the cell walls of the traditional Chinese medicines are destroyed in the process of adding the raw materials into ethanol for grinding, and simultaneously, the ethanol is used as an extracting agent to be beneficial to the dissolution of medicinal components, so that the bioavailability of the raw materials is improved. Grinding for 10-15 minutes can fully grind the raw materials to increase the contact area between the raw materials and the extractant, and can fully mix the extractant and the raw materials, thereby being beneficial to the extraction of active ingredients of the medicament, saving energy and reducing production cost. In detail, in the present example, the feed-to-liquid ratio of the raw material to ethanol was 1g (20-40) mL, which is advantageous for the dissolution of the active substance, thereby improving the extraction rate of the active substance.

And then the ground slurry is subjected to ultrasonic treatment at the temperature of 30-45 ℃ for 1-2 hours, so that the activity of the medicinal components can be preserved, and the dissolution of the active components can be accelerated under the treatment condition, thereby shortening the extraction time. In the embodiment, the power of the ultrasonic wave is 40-60W, and the use of the ultrasonic wave can not only improve the dispersion degree and the extraction rate of the raw materials in the extracting agent, but also accelerate the dissolution of the active substances and shorten the extraction time. However, the power of the ultrasound should be appropriate, and excessive power may change the structure of the pharmaceutically active substance to cause its failure, and the high power may generate high temperature to impair the life of the apparatus. If the power is too small, the effect caused by cavitation effect is small, the dispersion degree of the medicine is low, and the extraction is incomplete. After a plurality of tests, the power is preferably 40-60W.

Standing for 3-4 hr after ultrasonic treatment to precipitate and remove large granule residue, centrifuging, and collecting supernatant to remove light impurities in the solution, thereby purifying the medicine and enhancing the drug effect of the medicine. Further, in the embodiment, the rotation speed of the centrifugation is 600-800r/min, and the time of the centrifugation is 20-30 minutes. The effective components can be retained under the centrifugation condition, and light impurities in the supernatant can be separated from the liquid medicine, so that the content of the effective components in the medicine can be increased after concentration, and the residue can be prevented from being mixed into the liquid medicine to reduce the content of the effective components in the medicine and weaken the medicine effect. Distilling the supernatant under reduced pressure until the solid content is 50-60% to obtain a concentrated solution, adding pharmaceutical adjuvants into the concentrated solution, and mixing to obtain the traditional Chinese medicine composition for treating dermatitis, wherein the mass ratio of the concentrated solution to the pharmaceutical adjuvants is 1 (1-1.5). The concentrated solution and the pharmaceutic adjuvant in the proportion are mixed to obtain the ointment, the content of each component in the ointment is proper, the ointment can play the maximum pharmacodynamic action, and the side effect and the adverse reaction of the organism caused by excessive medicines are avoided.

Furthermore, the gel has a slow release effect on the medicinal ingredients, so that the purpose of positioning, slow release and controlled release can be achieved, and therefore, in the embodiment, the concentrated solution is combined with the pharmaceutic adjuvant of the gel matrix, so that the absorption rate of the medicament entering an organism is reduced, and a better treatment effect is achieved. Therefore, the preparation steps of the auxiliary materials for the traditional Chinese medicine in the embodiment are as follows: preparing carbomer solution with solid content of 1-2%, stirring until swelling, and adding triethanolamine to adjust pH to 6-8 to obtain medicinal adjuvant. The method comprises the steps of preparing a carbomer solution with the solid content of 1-2%, swelling the carbomer in water, stirring to accelerate the swelling rate of the carbomer, and preventing waste caused by swelling difficulty due to agglomeration of the carbomer. Stirring until carbomer swells, adding neutralizing agent triethanolamine to adjust pH to 6-8, and gradually increasing viscosity of carbomer water dispersion with increase of pH until it becomes transparent gel matrix. Then the concentrated solution is stirred with the gel matrix to disperse the medicine in the gel matrix. The preparation process is simple to operate, can realize large-scale mass production, can improve the extraction rate of the medicine and the curative effect of the medicine, is convenient to carry and paint the paste-shaped medicine, and has strong practicability.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment of the invention provides a traditional Chinese medicine composition for treating dermatitis, which comprises the following raw materials: 12g of fructus forsythiae, 18g of houttuynia cordata, 10g of raw sanguisorba officinalis, 6g of radix sophorae flavescentis, 7g of cortex dictamni, 10g of honeysuckle, 10g of astragalus membranaceus, 10g of angelica sinensis, 8g of rhizoma alismatis, 7g of fructus cnidii, 8g of liquorice, 12g of cortex lycii radicis, 10g of bitter almond oil, 10g of polygala tenuifolia, 10g of nacre and 5g of mint.

The embodiment of the invention provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which comprises the following steps: adding the raw materials into ethanol to prepare a mixture with a feed-liquid ratio of 0.04g/mL, and grinding the mixture for 13 minutes; then carrying out ultrasonic treatment on the mixture for 1.5 hours at the temperature of 40 ℃, wherein the ultrasonic power is 50W; standing for 3.5 hours after ultrasonic treatment, discarding residues, and centrifuging at the rotating speed of 750r/min for 25 minutes to obtain supernatant; distilling the supernatant under reduced pressure until the solid content is 55% to obtain concentrated solution; preparing carbomer solution with solid content of 1.5%, stirring until swelling, and adding triethanolamine to adjust pH to 7.5 to obtain medicinal adjuvant; the concentrated solution is added with the pharmaceutical excipients and mixed to obtain the traditional Chinese medicine composition for treating dermatitis, and the mass ratio of the concentrated solution to the pharmaceutical excipients is 1: 1.3.

Example 2

The embodiment of the invention provides a traditional Chinese medicine composition for treating dermatitis, which comprises the following raw materials: 10g of fructus forsythiae, 15g of houttuynia cordata, 9g of raw sanguisorba officinalis, 5g of radix sophorae flavescentis, 5g of cortex dictamni, 8g of honeysuckle, 9g of astragalus membranaceus, 9g of angelica sinensis, 6g of rhizoma alismatis, 5g of fructus cnidii, 5g of liquorice, 9g of cortex lycii radicis, 5g of polygala tenuifolia and 3g of mint.

The embodiment of the invention provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which comprises the following steps: adding the raw materials into a mixture with an ethanol preparation material-liquid ratio of 0.025g/mL, and grinding the mixture for 10 minutes; then carrying out ultrasonic treatment on the mixture for 1 hour at the temperature of 30 ℃, wherein the ultrasonic power is 40W; standing for 3 hours after ultrasonic treatment, discarding residues, and centrifuging at the rotating speed of 600r/min for 20 minutes to obtain supernatant; distilling the supernatant under reduced pressure until the solid content is 50% to obtain concentrated solution; preparing carbomer solution with solid content of 1%, stirring until swelling, and adding triethanolamine to adjust pH to 6 to obtain medicinal adjuvant; the concentrated solution is added with the medicinal auxiliary materials and mixed to obtain the traditional Chinese medicine composition for treating dermatitis, and the mass ratio of the concentrated solution to the medicinal auxiliary materials is 1:1.

Example 3

The embodiment of the invention provides a traditional Chinese medicine composition for treating dermatitis, which comprises the following raw materials: 15g of fructus forsythiae, 20g of houttuynia cordata, 12g of raw sanguisorba officinalis, 8g of radix sophorae flavescentis, 8g of cortex dictamni, 12g of honeysuckle, 12g of astragalus membranaceus, 12g of angelica sinensis, 10g of rhizoma alismatis, 8g of fructus cnidii, 5-10g of liquorice, 5g of bitter almond oil, 5g of mother of pearl and 6g of mint.

The embodiment of the invention provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which comprises the following steps: adding the raw materials into ethanol to prepare a mixture with a material-liquid ratio of 0.050g/mL, and grinding the mixture for 15 minutes; then carrying out ultrasonic treatment on the mixture for 2 hours at the temperature of 45 ℃, wherein the ultrasonic power is 60W; standing for 4 hours after ultrasonic treatment, discarding residues, and centrifuging at the rotating speed of 800r/min for 30 minutes to obtain supernatant; distilling the supernatant under reduced pressure until the solid content is 60% to obtain concentrated solution; preparing carbomer solution with solid content of 2%, stirring until swelling, and adding triethanolamine to adjust pH to 8 to obtain medicinal adjuvant; the concentrated solution is added with the medicinal auxiliary materials and mixed to obtain the traditional Chinese medicine composition for treating dermatitis, and the mass ratio of the concentrated solution to the medicinal auxiliary materials is 1: 1.5.

Example 4

The embodiment of the invention provides a traditional Chinese medicine composition for treating dermatitis, which comprises the following raw materials: 11g of fructus forsythiae, 16g of houttuynia cordata, 11g of raw sanguisorba officinalis, 7g of radix sophorae flavescentis, 6g of cortex dictamni, 9g of honeysuckle, 11g of astragalus membranaceus, 11g of angelica sinensis, 7g of rhizoma alismatis, 6g of fructus cnidii, 6g of liquorice, 10g of cortex lycii radicis, 8g of bitter almond oil, 8g of polygala tenuifolia and 8g of mother-of-pearl.

The embodiment of the invention provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which comprises the following steps: adding the raw materials into ethanol to prepare a mixture with the material-liquid ratio of 0.035g/mL, and grinding the mixture for 11 minutes; then carrying out ultrasonic treatment on the mixture for 1.5 hours at the temperature of 33 ℃, standing the mixture for 3.5 hours after ultrasonic treatment, discarding residues, and centrifuging the mixture for 28 minutes at the rotating speed of 650r/min to obtain supernatant; distilling the supernatant under reduced pressure until the solid content is 57% to obtain a concentrated solution; preparing carbomer solution with solid content of 1.4%, stirring until swelling, and adding triethanolamine to adjust pH to 6.5 to obtain medicinal adjuvant; the concentrated solution is added with the pharmaceutical excipients and mixed to obtain the traditional Chinese medicine composition for treating dermatitis, and the mass ratio of the concentrated solution to the pharmaceutical excipients is 1: 1.2.

Example 5

The embodiment of the invention provides a traditional Chinese medicine composition for treating dermatitis, which comprises the following raw materials: 14g of fructus forsythiae, 19g of houttuynia cordata, 11g of raw sanguisorba officinalis, 8.5g of radix sophorae flavescentis, 7g of cortex dictamni, 9g of honeysuckle, 9g of astragalus membranaceus, 10g of angelica sinensis, 7g of rhizoma alismatis, 7g of fructus cnidii and 8g of liquorice.

The embodiment of the invention provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which comprises the following steps: adding ethanol into the raw materials, grinding for 14 minutes, then carrying out ultrasonic treatment at 35 ℃ for 2 hours, standing for 3.5 hours, centrifuging to obtain a supernatant, carrying out reduced pressure distillation on the supernatant until the solid content of the supernatant is 56% to obtain a concentrated solution, adding pharmaceutical excipients into the concentrated solution, and mixing to obtain the traditional Chinese medicine composition for treating dermatitis, wherein the mass ratio of the concentrated solution to the pharmaceutical excipients is 1.0: 1.1.

Examples of effects

The therapeutic effects of the Chinese medicinal compositions for treating dermatitis prepared in examples 1 to 5 of the present invention were evaluated by the following methods, and the details are shown in Table 1.

Administration: 60 SPF-grade BALB/c 6-week-old mice were randomly selected and randomly divided into 6 groups, one of which was a blank group and the other 5 groups were labeled 1-5 as model groups, and the mice of model groups 1-5 after molding were smeared with the drugs of examples 1-5 for 2 times per day for 10 days with continuous administration, and the mice of the blank group were not administered.

Molding: the mouse is firstly administrated with the medicine of the embodiment 5 for 3 days, then the mouse is radiated by ultraviolet rays with the wavelength of 308nm and at the position of 15cm for 1.5h, the corresponding medicine is smeared for 1 time after 1h and 24h, the local skin of the mouse is in a latent period of 48h, the skin is visible to be red and swollen, and a solar dermatitis model is successfully established. The evaluation standard of the appearance index of local skin tissue, "I" skin is normal and has no red and swollen; skin with reddish brown spots appears in the skin of the 'II'; "III" skin is red and swollen, no exudation; "IV" skin is red and swollen, with exudation. The practical condition evaluation standard of the experimental pathological section, "I" skin tissue is normal, the epithelium is arranged neatly, the skin attachment is distributed evenly, and no pathological change is seen; the skin tissue of II is basically normal, and a little inflammatory cells infiltrate under the mucous membrane; III, skin tissues are basically normal, a large number of neutrophils are attached to the local surface, and inflammatory cells under the mucous membrane are infiltrated; and IV, skin tissue ulcer is formed, and granulomatous inflammation is accompanied with necrosis.

TABLE 1 evaluation of drug efficacy

As can be seen from the data in table 1, all the drugs in this example have a certain therapeutic effect on dermatitis, and the improvement effect is significant. Compared with the medicines in the embodiments, the traditional Chinese medicine composition for treating dermatitis in the embodiments 1 to 3 has a remarkable curative effect, the skin inflammation of the group of mice is basically repaired, only a few mice still have reddish brown spots, the curative effect in the embodiment 1 is the best, and the proportion of the medicines is the best. The poor curative effect of the embodiments 4-5 shows that the preparation method of the embodiment of the invention improves the curative effect of the medicament and enhances the curative effect.

In summary, the present invention aims to provide a traditional Chinese medicine composition for treating dermatitis, which has anti-inflammatory and antibacterial effects, and active substances in the medicine can remove dampness and relieve itching, and has good immunoregulation effect, so as to improve the immunity of the organism and restore the disordered immune state of the organism to be normal, thereby effectively resisting dermatitis, and has significant efficacy and small side effects. The invention also provides a preparation method of the traditional Chinese medicine composition for treating dermatitis, which is simple to operate, can realize large-scale mass production, can improve the extraction rate of the medicine and the curative effect of the medicine, is convenient to carry and smear the paste-shaped medicine, and has strong practicability.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating dermatitis is characterized by comprising the following raw materials in parts by weight:

10-15 parts of fructus forsythiae, 15-20 parts of houttuynia cordata, 9-12 parts of raw sanguisorba officinalis, 5-8 parts of radix sophorae flavescentis, 5-8 parts of cortex dictamni, 8-12 parts of honeysuckle, 9-12 parts of astragalus membranaceus, 9-12 parts of angelica sinensis, 6-10 parts of rhizoma alismatis, 5-8 parts of fructus cnidii and 5-10 parts of liquorice.

2. The traditional Chinese medicine composition for treating dermatitis as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:

12 parts of fructus forsythiae, 18 parts of houttuynia cordata, 10 parts of raw sanguisorba officinalis, 6 parts of radix sophorae flavescentis, 7 parts of cortex dictamni, 10 parts of honeysuckle, 10 parts of astragalus membranaceus, 10 parts of angelica sinensis, 8 parts of rhizoma alismatis, 7 parts of fructus cnidii and 8 parts of liquorice.

3. The traditional Chinese medicine composition for treating dermatitis as claimed in claim 1, further comprising 9-12 parts by weight of cortex lycii radicis and/or 5-10 parts by weight of bitter almond oil.

4. The traditional Chinese medicine composition for treating dermatitis as claimed in claim 1, further comprising 5-10 parts of polygala tenuifolia and/or 5-10 parts of nacre by weight.

5. The traditional Chinese medicine composition for treating dermatitis as claimed in any one of claims 1 to 4, further comprising 3 to 6 parts by weight of mint.

6. A method for preparing the traditional Chinese medicine composition for treating dermatitis as claimed in any one of claims 1 to 5, comprising the following steps:

adding ethanol into the raw materials, grinding for 10-15 minutes, then carrying out ultrasonic treatment at 30-45 ℃ for 1-2 hours, standing for 3-4 hours, centrifuging, taking supernate, carrying out reduced pressure distillation on the supernate until the solid content of the supernate is 50-60% to obtain a concentrated solution, adding a pharmaceutical adjuvant into the concentrated solution, and mixing to obtain the traditional Chinese medicine composition for treating dermatitis, wherein the mass ratio of the concentrated solution to the pharmaceutical adjuvant is 1 (1-1.5).

7. The preparation method of the traditional Chinese medicine composition for treating dermatitis as claimed in claim 6, wherein the feed-liquid ratio of the raw materials to the ethanol is 1g (20-40) mL.

8. The method for preparing a Chinese medicinal composition for treating dermatitis as claimed in claim 6, wherein the power of the ultrasound is 40-60W.

9. The method for preparing a Chinese medicinal composition for treating dermatitis as claimed in claim 6, wherein the rotation speed of the centrifugation is 600-800r/min, and the time of the centrifugation is 20-30 minutes.

10. The preparation method of the traditional Chinese medicine composition for treating dermatitis as claimed in claim 6, wherein the preparation steps of the pharmaceutic adjuvant are as follows: preparing carbomer solution with solid content of 1-2%, stirring until swelling, and adding triethanolamine to adjust pH to 6-8 to obtain the medicinal adjuvant.