CN105582233A - Traditional Chinese medicine composition for relieving fatigue of viscera and preparation method thereof - Google Patents

Traditional Chinese medicine composition for relieving fatigue of viscera and preparation method thereof Download PDF

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Publication number
CN105582233A
CN105582233A CN201610096908.6A CN201610096908A CN105582233A CN 105582233 A CN105582233 A CN 105582233A CN 201610096908 A CN201610096908 A CN 201610096908A CN 105582233 A CN105582233 A CN 105582233A
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China
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chinese medicine
parts
fatigue
medicine composition
internal organs
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刘冠萍
李柏霖
黄源春
林艳英
吴赛春
郑志远
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Guangxi Wuzhou Pharmaceutical Group Co Ltd
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Guangxi Wuzhou Pharmaceutical Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a traditional Chinese medicine composition for relieving fatigue of viscera and a preparation method thereof. The composition is prepared from the raw materials of rhizome of swordlike atractylodes, nutgrass galingale rhizome, combined spicebush root, diverse wormwood herb, flos caryophyllata, suberect spatholobus stem, seed of fewflower ichnocarpus, fortunella hindsii leaf, hypericum japonicum, garden balsam seed and holly root. An animal pharmacodynamics result shows that the traditional Chinese medicine composition disclosed by the invention can significantly improve the content of blood sugar in the blood of a rat with fatigue of viscera, obviously enhance the activity of lactate dehydrogenase and succinodehydrogenase in the liver, and meanwhile effectively reduce the content of lactic acid in skeletal muscle tissues and inhibit the activity of glucokinase, thereby improving the exercise tolerance of animals. The traditional Chinese medicine composition disclosed by the invention can be considered to have the effects of improving the spleen and qi deficiency symptoms, improving the exercise tolerance, and retarding exercise-induced fatigue of viscera for rats.

Description

A kind of for alleviating Chinese medicine composition of internal organs fatigue and preparation method thereof
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of for alleviate internal organs fatigue Chinese medicine composition andIts preparation method.
Background technology
Fatigue is the biochemical change procedure of the interior series of complex occurring of body. According to the biochemical meeting pair of international movementTired being defined as: " physiology course of body can not will can remain on a specified level or each organ can not be tieed upWhile holding its predetermined exercise intensity, be called fatigue ". Fatigue is to prevent that body from life-threatening excessive function occurringA kind of aversion response that exhaustion produces, reminds while producing fatigue and should lower working strength or stop motion,In order to avoid body injury. By the difference of tired happening part, can be divided into nervous centralis fatigue, nerve-muscle contactTired three classes of peripheries tired and limbs.
The traditional Chinese medical science thinks, internal organs fatigue is mainly due to the asthenic symptoms and psychological double factor of first gas consumption wound, and treatment not onlyWant qi-restoratives righting, tired the calming the nerves of also should dispelling. Comfortable smooth meaning, refreshing must peace, the heart is peaceful, and fatigue can disappear. Its main manifestations isFatigue and weak, lassitude, feel sleepy, do not have appetite, be even reluctant activity. Mainly comprise that spleen fatigue, liver are tiredLabor, heart fatigue, kidney fatigue, lung fatigue etc. Spleen fatigue (the few food of lazy speech): spleen wound is tired, causes that appetite is notShake, be disinclined to the diseases such as speech, how because of irregular diet, food and drink is excessive, or due to sorrow ponders over too much. Treatment is with benefitGas invigorating the spleen is main, holds concurrently with the promoting flow of qi and blood circulation. Liver fatigue (being irritable and getting angry easily) is many because food and drink is pungent, or pressure is excessive,Due to excessive fatigue. Often there is feverishness in palms and soles, short-tempered, constipation, the yellow and short puckery performance that waits of urine. ControlTreat and dispel tired inducing resuscitation as main taking Yangyin Rougan liver. Heart fatigue (palpitation and insomnia): how because of worry beyond measure or anxiety due to.Show as palpitaition, dreaminess, night sweat, thin white fur of tongue or limit point are slightly red. Treatment with mental-tranquilization, produce refreshing effect to the mind intoMain. Kidney fatigue (soreness of waist and knee joint): kidney fatigue shows as tinnitus, spirit is muddle-headed, soreness and weakness of waist and knees, heel is ached.Treatment is dispelled and is tiredly refreshed oneself as main taking strong kidney controlling nocturnal emission with astringent drugs. Lung fatigue (dry pharyngalgia) mostly is insufficiency of lung-QI,deficiency of lung-QI or foster institute is lost in prolonged illnessCause, show as hypopnea, mouth and nose are dry, pharyngalgia, dry skin, brittle hair etc. Treatment is to declare logical lungGas, it is main dispelling fatigue.
Alleviating at present internal organs fatigue is main mainly with traditional Chinese medical science conditioning, medicine, food, acupuncture, the motion qigong, spiritDeng being common method. For this situation, the invention provides a kind of for alleviating the Chinese medicine composition of internal organs fatigue.
Summary of the invention
The object of this invention is to provide a kind of for alleviating the Chinese medicine composition of internal organs fatigue;
Another object of the present invention is to provide a kind of for alleviating the preparation method of Chinese medicine composition of internal organs fatigue.
The object of the invention is to realize by following technical scheme:
Of the present invention for alleviating the Chinese medicine composition of internal organs fatigue, be to be prepared by the raw material of following weight portionForm: rhizoma atractylodis 70-82 part, rhizoma cyperi 135-170 part, root of three-nerved spicebush 70-82 part, Artemisia anomala 70-82 part, fourthFragrant 35-42 part, reticulate millettia 70-82 part, red bark of eucommia 70-82 part, mountain tangerine leaf 70-82 part, hypericum japonicum 70-82Part, impetuous 70-82 part, Flos Ilicis Asprellae 70-82 part.
Preferably, be to be prepared from by the raw material of following weight portion: 76 parts of rhizoma atractylodis, 153 parts of rhizoma cyperis, the root of three-nerved spicebush76 parts, 76 parts of Artemisia anomalas, 38 parts of cloves, 76 parts of reticulate millettias, 76 parts of the red barks of eucommia, 76 parts, mountain tangerine leaf,76 parts of hypericum japonicum, 76 parts of the seeds of garden balsam, 76 parts of Flos Ilicis Asprellae.
Below crude drug source of the present invention:
Rhizoma atractylodis: this product is feverfew Atractylis lancea Atractylodeslancea (Thunb.) DC. or Atractylis chinensisThe dry rhizome of Atractylodeschinensis (DC.) Koidz.. Spring, Qiu Erji excavate, and remove silt, shineDry, hit fibrous root. [nature and flavor with return through] are pungent, bitter, temperature. Return spleen, stomach, Liver Channel. [function with cure mainly]Drying damp and strengthening spleen, the Ao Han that dispels the wind, improving eyesight. For damp retention in middle-jiao, abdominal fullness and distention, has loose bowels, oedema, and beriberi impotence is preesed,Arthralgia due to wind-dampness, anemofrigid cold, yctalopia, eyes dusk is puckery.
Rhizoma cyperi: this product is the dry rhizome of sedge nutgrass flatsedge CyperusrotundusL.. Excavate autumn,Sing the hair must, put in boiling water, slightly boil or steam after dry, or burn and directly dry afterwards. [nature and flavor with return through] pungent,Micro-hardship, micro-sweet, flat. Return liver, spleen, tri-jiao channel. [function with cure mainly] soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, adjustsMeridian and relieving pain. For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is vexed,Turgor pain, irregular menstruation, through closing dysmenorrhoea.
The root of three-nerved spicebush: this product is the dried root of canella root of three-nerved spicebush Linderaaggregata (Sims) Kosterm..All can excavate the whole year, removes radicula, cleans, and takes advantage of fresh slices, dries, or directly dry. [nature and flavor with return through]Pungent, temperature. Return lung, spleen, kidney, urinary bladder channel. [function with cure mainly] promoting qi circulation and relieving pain, warming kidney for dispelling cold. For coldThe solidifying stagnation of the circulation of vital energy, chest and abdomen swelling and pain, the circulation of vital energy in the wrong direction is breathed heavily urgency, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache.
Artemisia anomala: this product is feverfew artemisia anomalas ArtemisiaanomalaS.Moore or white luxuriant wormwood artemisia ArtemisiaActifloraWall.ex.DC. dry aerial parts. When summer, fall flowering, tap, remove impurity, dry.[nature and flavor] micro-hardship, pungent, temperature. [function with cure mainly] promoting blood circulation to remove blood stasis, inducing meastruation to relieve menalgia, inducing diuresis and reducing edema, disappear long-pendingDe-swelling. For abdominalgia with blood stasis in postpartum, irregular menstruation, amenorrhoea, dyspeptic abdominal distention, traumatic injury.
Cloves: this product is the dry flower of plant clove of myrtaceae EugeniacaryophyllataThunb..In the time that bud turns red by green, pluck, dry. [nature and flavor with return through] are pungent, temperature. Return spleen, stomach, lung, kidney channel.[function with cure mainly] warming middle energizer to descend adverse-rising qi, tonifies the kidney and support yang. For deficiency-cold in spleen and stomach, hiccup vomiting, food is few vomits and diarrhoea, the heartAbdomen crymodynia, impotence due to deficiency of the kidney.
Reticulate millettia: be the dry rattan of legume spatholobus suberectus SpatholobussuberectusDunn. Autumn,Two seasons of winter gather, and remove branches and leaves, and section, dries. [nature and flavor with return through] are bitter, sweet, temperature. Return liver, kidney channel.[function with cure mainly] blood circulation promoting and enriching, menstruction regulating and pain relieving, stimulates the circulation of the blood and cause the muscles and joints to relax. For irregular menstruation, dysmenorrhoea, through closing,Arthralgia due to wind-dampness, paralysis and numbness, the deficiency of blood is sallow.
The red bark of eucommia: be apocynaceae plant chun parabarium bark ParabariumchunianumTsiang, parabarium huaitingii Chun et TsiangParabariumhuaitingiiChunetTsiang, eucommia vine Parabariummicranthun (A.DC.) PierreOr the dry bark of flower hide glue rattan EcdysantherautilisHay.etKaw.. Can adopt the whole year, strips bark, dryDry. [nature and flavor with return through] are bitter, puckery, micro-pungent, put down. [function with cure mainly] dispelling, collateral-activating, strong waist knee, strong muscleBone, detumescence. For polio, treating rheumatic ostealgia, traumatic injury.
Mountain tangerine leaf: this product is the little tangerine Glycosmisparviflora in rutaceae little Hua mountain (Sims) Kurz'sDry leaf. [nature and flavor] are bitter, micro-pungent, flat. [function with cure mainly] eliminating stasis to subdue swelling, reduces phlegm, and disappears long-pending. Be used for fallingPlay damage, cold cough, dyspepsia distending pain.
Hypericum japonicum: this product is the dry herb of Garcinia maingayii hypericum japonicum HypericumjaponicumThunb..Spring, summer excavate when two seasons, the flowers are in blossom, remove impurity, dry. [nature and flavor with return through] are bitter, pungent, flat. Return liver,The spleen channel. [function with cure mainly] eliminating dampness and heat, eliminating stasis to subdue swelling. For acute hepatitis, chronic hepatitis, sore furuncle carbuncle is swollen.
Impetuous: this product is the dry mature seed of Balsaminaceae plant balsamine ImpatiensbalsaminaL..Summer, autumn gather when fruit is about to maturation, dry, and remove pericarp and impurity. [nature and flavor with return through] micro-hardship,Pungent, temperature; Slightly poisonous. Return lung, Liver Channel. [function with cure mainly] broken soft heavily fortified point of blood, disappears long-pending. For note of the ancient Chinese lump in the abdomen lump in the abdomen,Through closing, dysphagic.
Flos Ilicis Asprellae: this product is holly plant gradations marked on the beam of steelyard tree Ilexasprella (HookeretAmott) ChampionexDry root and the stem of Bentham. All can gather the whole year, removes spray and leaf, cleans, and takes advantage of when fresh and cut or splitIn flakes, piece or section, dry. [nature and flavor with return through] are bitter, micro-sweet, cool. Return lung, spleen, stomach warp. [function withCure mainly] clearing heat and detoxicating, promote the production of body fluid to quench thirst, reducing pharyngeal swelling, blood stasis removing analgesic. For cold, fever, cough with lung heat,Tianjin wound is thirsty, and abscess of throat is fallen and beaten stasis of blood pain.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, shouldMethod is to adopt water extraction to get. Concrete preparation method is as follows:
Get rhizoma atractylodis, rhizoma cyperi, the root of three-nerved spicebush, Artemisia anomala, cloves, reticulate millettia, the red bark of eucommia, mountain tangerine leaf, hypericum japonicum,Impetuous, Flos Ilicis Asprellae, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medicinal material gross weight, everyInferior extraction time is 1-3 hour, merges extract, filters, and when filtrate is concentrated into 60-80 DEG C, relative density is1.05-1.20 clear cream, to obtain final product.
Of the present invention for alleviating the Chinese medicine composition of internal organs fatigue, can carry with pharmaceutically acceptableBody coordinates, and makes various common dosage forms, as tablet, granule, capsule, chewable tablets, pill etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc.
Wetting agent and adhesive: purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc.
Disintegrant: starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc.
Lubricant: dolomol, superfine silica gel powder, talcum powder, polyethylene glycol etc.
Cosolvent: water, ethanol, glycerine, propane diols, liquid paraffin, plant wet goods.
Flavouring: sucrose, monose, aromatic etc.
Anticorrisive agent: benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc.
Fang Xie: the card of overstrain, the first impairment of the spleen, spleen fortune is lost to be good for and is seen that food is few indigestion and loss of appetite, moreover endogenous damp formation, causes fourLimb is not received idle feelings and is had a liking for sleeping; Internal lesion caused by overexertion qi and blood person, liver is lost collection, and the catharsis of liver is not normal, causes functional activity of QI being not smooth, and disease is seenSpiritlessness and weakness, the lazy speech of breathing hard; Can undermine again kidney, disease is seen soreness and weakness of waist and knees. Our with strengthening the spleen and stomach, dispersing stagnated hepatoqiFor the main rules for the treatment of, by the internal organs fatigue of controlling internal lesion caused by overexertion. In side, rhizoma atractylodis are warm in nature, and taste is pungent, bitter, return spleen, stomach warp, forDrying damp and strengthening spleen key medicine, the kind dry spleen of merit wets, changes turbid, makes spleen transport strongly, promotes the angry blood of water paddyization. Work sweatGo out the heresy of easily having a cold when wind, rhizoma atractylodis are the double effect expelling pathogenic wind from the body surface again, is two to arrogate to oneself its merit with the card of controlling overstrain.Rhizoma cyperi master enters Liver Channel gas and divides, and the pungent energy of its taste is loose, bitter can receipts, sweet energy with, be especially apt to soothing liver-qi stagnation, regulating functional activities of qi,Promoting qi circulation and relieving pain, pungent loose and enter the spleen channel again, can regulating the flow of QI to ease the stomach, good by the effect of controlling the taste stagnation of the circulation of vital energy. We reuse rhizoma atractylodis,Rhizoma cyperi is monarch, and rhizoma atractylodis invigorating the spleen is transported and promoted hair tonic vim and vigour to make liver keep fortune, and the easypro irritability of rhizoma cyperi also helps taste fortuneChange, i.e. the meaning of " earth being dredged by wood ", therefore two medicines 5 bring out the best in each other for monarch mutually. Root of three-nerved spicebush Xin Kaiwen is loose, kindDredging mechanism of qi, helps rhizoma cyperi to play the effect of regulating functional activities of qi, enters spleen and in wide, helps rhizoma atractylodis invigorating the spleen and stomach, again kind temperature compensation kidneySun; Artemisia anomala has the merit of promoting digestion and removing indigestion, can help rhizoma atractylodis invigorating the spleen and transporting and transforming nutrients from foodstuff; The pungent wet perfume (or spice) of cloves, main enter spleen,Stomach warp, available controlling eaten few indigestion and loss of appetite disease, enters again kidney channel, has the effect of warming and invigorating kidney Yang; Reticulate millettia enters Liver Channel and enriches bloodInvigorate blood circulation, anemia that can help assertive evidence, again double effect of regulating channels and activating collateral and vigorous blood. The root of three-nerved spicebush, Artemisia anomala, clovesWith reticulate millettia four traditional Chinese medicine be ministerial drug altogether. We's assistant is with the red bark of eucommia, mountain tangerine leaf, hypericum japonicum, and the red bark of eucommia enters liver, kidneyWarp, has strong psoas, the merit of strengthening the bones and muscles, the available soreness of waist and knee joint of controlling internal lesion caused by overexertion kidney yang; Mountain tangerine leaf enters Liver Channel and stagnation resolvationDetumescence, adjusts and reaches blood vessels, enters again stomach warp, and kind reducing phlegm disappears long-pendingly, and with controlling, the indigestion and loss of appetite effect of dyspepsia is good; Hypericum japonicum has dampness removingEffect, again can activating blood circulation and reducing swelling, be applicable to we and control card. Impetuous can manage it the stasis of blood, the available blood of controlling due to impairment of qiAre obstructed, have the effect of double sending down abnormally ascending, and our all medicines mostly are the floating property of liter, float too therefore the seed of garden balsam can be entangled we's liter,For we make medicine; Flos Ilicis Asprellae bitter, cool in nature, merit is apt to clearing heat and promoting fluid, and we reuse Flos Ilicis Asprellae for making, because of the card of internal lesion caused by overexertionConsumption excess of four natures in foods or drugs causing damage of essence, easily accumulates interior heat, and we have the product of the pungent temperature of all tastes for being good for beneficial liver spleen again, and Flos Ilicis Asprellae can anti-ly be hindered the fraud in Tianjin.All medicines share above, treat both principal and secondary aspect of disease in assertive evidence.
Provided by the invention a kind ofly have the following advantages for the Chinese medicine composition of alleviating internal organs fatigue:
1, in the present invention's prescription, each medicine share, and jointly plays strengthening the spleen and stomach, the effect of dispersing stagnated hepatoqi, Neng GouqiTo the effect of alleviating preferably internal organs fatigue.
2, in Chinese People's Anti-Japanese Military and Political College's mouse internal organs fatigue test, compared with model group, give the rat after the present invention, temperChronic diseases marked by deficiency of vital energy shape significantly improves, and exercise tolerance obviously improves, and motility internal organs fatigue is effectively improved. And part is doneBe better than positive controls by effect.
3, present composition formula is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
Further illustrate the present invention below by embodiment. It should be understood that embodiments of the invention be forThe present invention instead of limitation of the present invention are described. The simple modifications that essence according to the present invention is carried out the present inventionAll belong to the scope of protection of present invention.
Embodiment 1
Get rhizoma atractylodis 76g, rhizoma cyperi 153g, root of three-nerved spicebush 76g, Artemisia anomala 76g, cloves 38g, reticulate millettia 76g, redBark of eucommia 76g, mountain tangerine leaf 76g, hypericum japonicum 76g, impetuous 76g, Flos Ilicis Asprellae 76g, extracting in water 3 times, everyInferior amount of water is equivalent to 6 times of medicinal material gross weight, and each extraction time is 1 hour, merges extract, filter,The clear cream that when filtrate is concentrated into 60 DEG C, relative density is 1.20, is dried to dried cream powder, pulverizes, and adds auxiliary material to form sedimentPowder, cane sugar powder, talcum powder, dolomol, make granule.
Embodiment 2
Get rhizoma atractylodis 70g, rhizoma cyperi 135g, root of three-nerved spicebush 70g, Artemisia anomala 70g, cloves 35g, reticulate millettia 70g, redBark of eucommia 70g, mountain tangerine leaf 70g, hypericum japonicum 70g, impetuous 70g, Flos Ilicis Asprellae 70g, extracting in water 2 times, everyInferior amount of water is equivalent to 8 times of medicinal material gross weight, and each extraction time is 2 hours, merges extract, filter,The clear cream that when filtrate is concentrated into 70 DEG C, relative density is 1.15, is dried to dried cream powder, pulverizes, and adds auxiliary material to form sedimentPowder, cane sugar powder, talcum powder, dolomol, make granule.
Embodiment 3
Get rhizoma atractylodis 82g, rhizoma cyperi 170g, root of three-nerved spicebush 82g, Artemisia anomala 82g, cloves 42g, reticulate millettia 82g, redBark of eucommia 82g, mountain tangerine leaf 82g, hypericum japonicum 82g, impetuous 82g, Flos Ilicis Asprellae 82g, extracting in water 1 time, everyInferior amount of water is equivalent to 12 times of medicinal material gross weight, and each extraction time is 3 hours, merges extract, filterCross, the clear cream that when filtrate is concentrated into 80 DEG C, relative density is 1.10, is dried to dried cream powder, pulverizes, and adds auxiliaryMaterial starch, cane sugar powder, talcum powder, dolomol, make granule.
Pharmacodynamics test: Chinese People's Anti-Japanese Military and Political College's mouse internal organs fatigue
1. experiment material
1.1 animal
SD rat, male, SPF level, body weight 180～220g,, tests purchased from Guangxi Medical University by 40Animal center.
1.2 reagent
Amber dehydrogenase kit, lactic dehydrogenase enzyme reagent kit, Coomassie brilliant blue kit, glucokinaseELISA kit, glucose oxidase method are surveyed blood sugar kit (Nanjing is built up). ;
1.3 medicine
Positive group: gadol extract (formed by this laboratory self-control, through HPLC detect purity 95% withOn)
Embodiment group: embodiment 1 granule
2. experimental technique
2.1 groupings, modeling: experimental rat adaptability was raised after 3 days, and animal is divided into normally at random by body weightGroup, model control group, embodiment group, positive drug group, 10 every group. Except normal group, other organize employingMultifactor method is set up the tired model of the temper chronic diseases marked by deficiency of vital energy-sports type internal organs. Method is as follows:
Modeling gives 50 ° of white wine by 1ml/100g rat weight gavage on the 1st day. From modeling the 2nd day,Every mornings nine point, give 4 DEG C of vinegars by 1ml/100g rat weight gavage, give by weight 8% simultaneouslyFeed mixed fodder; Afternoons three point, rat tails bear a heavy burden (weight quality be rat weight 10%). Put intoThe tank went swimming that depth of water 50cm, water temperature are 20 DEG C, swims to the endurance limit (nose submerges under water more than 3s),Continuous 14 days.
2.2 administrations and animal processing: blank group and Spleen-Qi Deficiency model distill by 20ml/kg weightWater, embodiment group and positive drug group give respectively corresponding medicine, continuous 15 days.
2.3 indexs detect
2.3.1 biology sign is observed
Modeling first day and administration weigh the body weight of rat last day, the weight gain value before and after experiment with computing;Administration detects the anus temperature of rat last day. The autonomic activities feelings of observing rat every day during modeling and during administrationCondition, fur color and luster, food-intake, swimming power exhaust time, stool situation, and according to temper chronic diseases marked by deficiency of vital energy disease scoring markStandard is carried out macroscopic view scoring to animal. Each item rating is added, draw scoring and, scoring and higher, prompting symptomMore serious. Temper chronic diseases marked by deficiency of vital energy disease and standards of grading are as table 1:
Table 1 rat spleen qi deficiency disease and standards of grading
2.3.2 measuring content of blood sugar
Experiment finished fasting the previous day after 24 hours, adopted docking blood extracting method, got 1ml blood in preparation liverIn the anticoagulant tube of elementization, then stop blooding to rat with starch, adopt determination of glucose oxidase animal blood glucose to containAmount
2.3.3 lactic acid content, succinate dehydrogenase in hepatic tissue glucokinase (GK) and skeletal muscle(SDH) active detection
After experiment finishes, the chloraldurate of all animal lumbar injections 10%, after holonarcosis, opens abdominal cavity,Expose liver, and rapidly from right lobe of liver inferior horn clip one fritter (about 0.3g) hepatic tissue. In ice physiological salineWash away blood, wash away after moisture with filter paper, accurately take its weight. Ratio according to 1:9 (W/V) addsPhysiological saline, 10% tissue homogenate is made in homogenate, then through 3500r/min, 4 DEG C of low-temperature centrifugation 10min,Get supernatant as testing sample solution, 20 DEG C of Refrigerator stores of ﹣ are to be measured. Coomassie brilliant blue method is measured liver homogenateProtein content in liquid, suppresses the work of glucokinase in method (ELISA kit) mensuration sample with competitivenessProperty. Concrete implementation step operates in strict accordance with kit description.
2.3.4 serum lactic dehydrogenase (SLDH) (LDH) is active detects
Separate abdominal aorta, with the 10ml injection needle 8ml that takes a blood sample, after stand at low temperature 20min, withThe centrifugal 10min of 3500r/min, draws upper serum, and-20 DEG C of Refrigerator stores are to be measured. Getting serum adopts lactic acid de-Hydrogen enzyme (LDH) kit detects through the corresponding enzymatic activity of row. Concrete implementation step is in strict accordance with kit descriptionOperation.
3. statistical procedures
Respectively the quantitative testing result of biochemistry of group represents with mean ± standard deviation by measurement data, and the difference between each group is dividedAnalyse and adopt t inspection. The statistical software using is SPSS13.0, and P < 0.05 thinks that difference has conspicuousness.
4. experimental result
The changes of weight of 4.1 medicines on the tired rat of internal organs and the impact of Spleen-Qi Deficiency symptom macroscopic view scoring
Result is as shown in table 2, and with the comparison of blank group, model group body weight gain rate obviously reduces (P < 0.01),The scoring of Spleen-Qi Deficiency symptom macroscopic view significantly increases (P < 0.01); With model group comparison, positive group and embodiment groupBody weight gain rate significantly increases (P < 0.01), and the scoring of Spleen-Qi Deficiency symptom macroscopic view significantly reduces (P < 0.01)
The each treated animal changes of weight of table 2 and the scoring of temper chronic diseases marked by deficiency of vital energy disease macroscopic view
Note: with the comparison of blank group, * * P < 0.01; With model group comparison, #P < 0.05, ##P < 0.01.
The impact of 4.2 medicines on the tired rat blood sugar content of internal organs and lactic acid dehydrogenase activity variation
Result is as shown in table 3, and with the comparison of blank group, model group blood-sugar content obviously declines (P < 0.05), LDHActive significantly reduce (P < 0.01); With model group comparison, the blood-sugar content of positive group and embodiment group obviously risesHigh (P < 0.05), active significantly rise (P < 0.01) of LDH.
The each treated animal blood-sugar content of table 3 and serum lactic dehydrogenase (SLDH) activity change
Note: with the comparison of blank group, * * P < 0.01; With model group comparison, #P < 0.05, ##P < 0.01.
4.3 medicines are to lactic acid content, the active change of SDH in hepatic tissue GK and skeletal muscle in the tired rat of internal organsThe impact of changing
Result is as shown in table 4, and with the comparison of blank group, the GK activity of model group animal, lactic acid content obviously riseHigh (P < 0.01 or P < 0.05), active significantly decline (P < 0.01) of SDH; With model group comparison, positive drugGroup all obviously declines (P < 0.01 or P < 0.05) with GK activity, the lactic acid content of embodiment group, SDH activitySignificantly increase (P < 0.01).
Lactic acid content, SDH activity change in hepatic tissue GK and skeletal muscle in the each treated animal of table 4
5. discuss
Theory of traditional Chinese medical science thinks, motility internal organs fatigue is a kind of functional disease taking the temper chronic diseases marked by deficiency of vital energy as cardinal symptomDisease, cardinal symptom comprises fatigue and asthenia, poor appetite, Body weight loss, stool malt sugar, thereby has reduced bodyCarry out the efficiency of glycogen metabolism, reduce the exercise tolerance of body, make body easily tired. Lactic dehydrogenase(LDH) in the time of strenuous exercise, its total activity can raise, thereby the lactic acid that accelerates to pile up in muscle changes third intoKetone acid, the generation of delay fatigue or the elimination accelerating fatigue. Succinate dehydrogenase (SDH) is tricarboxylic acid cycleMarker enzyme, be one of important enzyme of electron transport chain and oxidative phosphorylation in cell glucose metabolism, its activity canReflect mitochondrial energetic supersession situation, the reduction of its activity may cause slowing down even of cellular energy metabolismStop, causing metabolism obstacles of blood glucose. Glucokinase (GK) is synthetic starting rate-limiting enzyme and the pass of mediation glycogenKey enzyme, the enhancing of its activity, can accelerate the synthetic of glycogen, otherwise the glucose level in blood circulation is declined,Thereby the utilization ratio to glycogen while having reduced body strenuous exercise. This experimental result shows, Chinese drug-treated group of the present inventionCompound can significantly improve blood-sugar content (P < 0.05) in the tired rat blood of internal organs, obviously strengthens lactic dehydrogenaseAnd the activity (P < 0.01) of succinate dehydrogenase in liver, effectively reduce the lactic acid in skeletal muscle tissue simultaneouslyContent (P < 0.05), suppresses the activity (P < 0.01) of glucokinase, thereby improves the exercise tolerance of animal.Meanwhile, Chinese medicine composition of the present invention also significantly improves the temper chronic diseases marked by deficiency of vital energy symptom (P < 0.01) of the tired rat of internal organs,Slow down the body weight loss (P < 0.01) of animal.
Overall experiment effect demonstration, Chinese medicine composition of the present invention can effectively improve the temper chronic diseases marked by deficiency of vital energy of the tired rat of internal organsShape, improves tolerance of exercise, slows down motility internal organs fatigue.
Conclusion: Chinese medicine composition of the present invention can effectively improve the Spleen-Qi Deficiency symptom of the tired rat of internal organs, improves motionTolerance, slows down exercise induced fatigue.
Although, above use general explanation, detailed description of the invention and test, the present invention is done detailedDescription, but on basis of the present invention, can make some modifications or improvements it, this is to those skilled in the artApparent. Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention,All belong to the scope of protection of present invention.

Claims (5)

1. for alleviating a Chinese medicine composition for internal organs fatigue, it is characterized in that it is to be prepared from by the raw material of following weight portion: rhizoma atractylodis 70-82 part, rhizoma cyperi 135-170 part, root of three-nerved spicebush 70-82 part, Artemisia anomala 70-82 part, cloves 35-42 part, reticulate millettia 70-82 part, red bark of eucommia 70-82 part, mountain tangerine leaf 70-82 part, hypericum japonicum 70-82 part, impetuous 70-82 part, Flos Ilicis Asprellae 70-82 part.
2. as claimed in claim 1 for alleviating the Chinese medicine composition of internal organs fatigue, it is characterized in that it is to be prepared from by the raw material of following weight portion: 76 parts of rhizoma atractylodis, 153 parts of rhizoma cyperis, 76 parts of the roots of three-nerved spicebush, 76 parts of Artemisia anomalas, 38 parts of cloves, 76 parts of reticulate millettias, 76 parts of the red barks of eucommia, 76 parts, mountain tangerine leaf, 76 parts of hypericum japonicum, 76 parts of the seeds of garden balsam, 76 parts of Flos Ilicis Asprellae.
3. as claimed in claim 1 or 2 for alleviating the Chinese medicine composition of internal organs fatigue, it is characterized in that its active component adopts water extraction to get and be prepared from.
4. as claimed in claim 3 for alleviating the Chinese medicine composition of internal organs fatigue, it is characterized in that its active component is prepared from by the following method: get rhizoma atractylodis, rhizoma cyperi, the root of three-nerved spicebush, Artemisia anomala, cloves, reticulate millettia, the red bark of eucommia, mountain tangerine leaf, hypericum japonicum, the seed of garden balsam, Flos Ilicis Asprellae, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time is 1-3 hour, merge extract, filter, the clear cream that when filtrate is concentrated into 60-80 DEG C, relative density is 1.05-1.20, to obtain final product.
5. for alleviating a Chinese medicine preparation for internal organs fatigue, by preparing and form for alleviating in the Chinese medicine composition of internal organs fatigue and pharmaceuticals industry acceptable carrier described in claim 1 or 2.
CN201610096908.6A 2016-02-22 2016-02-22 Traditional Chinese medicine composition for relieving fatigue of viscera and preparation method thereof Pending CN105582233A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101513437A (en) * 2008-02-21 2009-08-26 中国科学院上海药物研究所 Antifatigue Chinese pharmaceutical composition and preparation method thereof
CN102648950A (en) * 2012-04-20 2012-08-29 贵州省铜仁梵天生物科技有限责任公司 Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101513437A (en) * 2008-02-21 2009-08-26 中国科学院上海药物研究所 Antifatigue Chinese pharmaceutical composition and preparation method thereof
CN102648950A (en) * 2012-04-20 2012-08-29 贵州省铜仁梵天生物科技有限责任公司 Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains

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