CN101244247B - Pharmaceutical combination for treating cervical vertebra disease and waist and leg pain, and preparation thereof - Google Patents
Pharmaceutical combination for treating cervical vertebra disease and waist and leg pain, and preparation thereof Download PDFInfo
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- CN101244247B CN101244247B CN2007100640012A CN200710064001A CN101244247B CN 101244247 B CN101244247 B CN 101244247B CN 2007100640012 A CN2007100640012 A CN 2007100640012A CN 200710064001 A CN200710064001 A CN 200710064001A CN 101244247 B CN101244247 B CN 101244247B
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Abstract
The invention discloses a medicine composition for curing cervical spondylosis, lumbar spondylopathy or lumbocrural pain, the composition comprises forty-one active pharmaceutical ingredients such as mankshood, kusezoff monkshood, Common Monkshood Mother Root, zingiber, Rhizoma Gastrodiae, lumbricus, batryticated silkworm, chilopod, safflower, rhizoma ligustici wallichii and olibanum. The medicine composition has the advantages of easing the compression stimulus of the tissues such as nerve root and blood vessel, reinforcing and improving local blood circulation, promoting metabolism, reinforcing tension, elasticity and tolerance of muscles, activating blood circulation to resolve masses, relaxing muscles and tendons and activating the collaterals, dispelling wind and eliminating dampness, relieving muscular cramp and adhesion around joints, eliminating shrinkage of tendon, ligaments and joint capsule, recovering extension degree of joints, easing joint movement, spreading spasm of muscles, smoothing vital energy and achieving the purpose of curing ankylosis.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of cervical spondylosis and lumbago and skelalgia and preparation method thereof.
Background technology
Cervical spondylosis and lumbar spondylosis are because the affection of exogenous wind-cold damp, wound strain or in congenital malformation, cause narrowing of intervertebral space, neck, degenerative lumbar and the damage of vertebral body surrounding tissue, caused vertebral body muscle on every side, ligament, relaxing of joint capsule, ligament plumpness and even calcification, the vertebral body hyperosteogeny, little joint hyperplasia, prolapse of intervertebral disc causes the front and back, joint and indulges belt sag and cause the vertebral body unstability, and surrounding soft tissue's strain, inflammation, edema, spasm and even degeneration, adhesions etc. cause neck, the neural spinal cord of waist, the stimulation and the compressing of tissue such as blood vessel, thereby produce a series of clinical symptom grouping of the corresponding tissue of getting involved, real is primary disease.The inventor thinks according to this etiology and pathology, for neck, the treatment of lumbar spondylosis, mainly be to recover the physiology curvature of vertebral body, enlarge intervertebral space and intervertebral foramina, stick with thermotherapy plaster of the present invention, to alleviate to nerve root, the compressing of tissue such as blood vessel stimulates, strengthen and improve local blood circulation, enhance metabolism, strengthen the tension force of muscle, elastic force and tolerance, blood circulation promoting and dispersing pathogen accumulation, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, remove muscle spasm, the adhesion around the joint of loosening, eliminate tendon, ligament, contraction is assisted in the joint, recover the range of extension in joint, easing joint movement is unfolded the muscle arteries and veins, QI and blood is unobstructed, reaches the purpose of treatment ankylosis.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of cervical spondylosis and lumbago and skelalgia.
Another purpose of the present invention is to provide a kind of preparation of drug combination method for the treatment of cervical spondylosis and lumbago and skelalgia.
The 3rd purpose of the present invention is to provide a kind of purposes of pharmaceutical composition.
The present invention is achieved through the following technical solutions:
Radix Aconiti Lateralis Preparata 13-39 weight portion Radix Aconiti Kusnezoffii 13-39 weight portion Radix Aconiti 13-39 weight portion
Rhizoma Zingiberis 15-45 weight portion Rhizoma Gastrodiae 13-39 weight portion Pheretima 13-39 weight portion
Bombyx Batryticatus 13-39 weight portion Scolopendra 10-30 weight portion Flos Carthami 13-39 weight portion
Rhizoma Chuanxiong 13-39 weight portion Olibanum 10-30 weight portion Myrrha 10-30 weight portion
Caulis Spatholobi 13-39 weight portion Radix Achyranthis Bidentatae 13-39 weight portion Rhizoma Arisaematis 13-39 weight portion
Semen Sinapis Albae 10-30 weight portion Radix Saposhnikoviae 13-39 weight portion Rhizoma Et Radix Notopterygii 13-39 weight portion
Herba Asari 13-39 weight portion Radix Angelicae Pubescentis 13-39 weight portion Radix Gentianae Marcrophyllae 13-39 weight portion
Fructus Chaenomelis 13-39 weight portion Radix Clematidis 13-39 weight portion Herba speranskiae tuberculatae 13-39 weight portion
Rhizoma Homalomenae 13-39 weight portion Semen Strychni 13-39 weight portion Flos Caryophylli 15-45 weight portion
Rhizoma Cibotii 15-45 weight portion Cortex Eucommiae 13-39 weight portion Rhizoma Drynariae 13-39 weight portion
Radix Angelicae Sinensis 13-39 weight portion Flos Daturae 13-39 weight portion Pyritum 13-39 weight portion
Borneolum Syntheticum 10-30 weight portion Camphora 15-45 weight portion Ramulus Mori 15-45 weight portion
Ramulus Persicae 15-45 weight portion Os Canitis 30-90 weight portion Radix Notoginseng 5-15 weight portion
Dexamethasone 25-75 weight portion ibuprofen 15-45 weight portion
The optimum ratio of pharmaceutical composition of the present invention is:
Radix Aconiti Lateralis Preparata 26 weight portion Radix Aconiti Kusnezoffii 26 weight portion Radix Aconitis 26 weight portions
Rhizoma Zingiberis 30 weight portion Rhizoma Gastrodiaes 26 weight portion Pheretimas 26 weight portions
Bombyx Batryticatus 26 weight portion Scolopendras 20 weight portion Flos Carthamis 26 weight portions
Rhizoma Chuanxiong 26 weight portion Olibanums 20 weight portion Myrrhas 20 weight portions
Caulis Spatholobi 26 weight portion Radix Achyranthis Bidentataes 26 weight portion Rhizoma Arisaematiss 26 weight portions
Semen Sinapis Albae 20 weight portion Radix Saposhnikoviaes 26 weight portion Rhizoma Et Radix Notopterygiis 26 weight portions
Herba Asari 26 weight portion Radix Angelicae Pubescentiss 26 weight portion Radix Gentianae Marcrophyllae 26 weight portions
Fructus Chaenomelis 26 weight portion Radix Clematidis 26 weight portion Herba speranskiae tuberculataes 26 weight portions
Rhizoma Homalomenae 26 weight portion Semen Strychnis 26 weight portion Flos Caryophyllis 30 weight portions
The Rhizoma Cibotii 30 weight portion Cortexs Eucommiae 26 weight portion Rhizoma Drynariae 26 weight portions
Radix Angelicae Sinensis 26 weight portion Flos Daturaes 26 weight portion Pyritums 26 weight portions
Borneolum Syntheticum 20 weight portion Camphoras 30 weight portion Ramulus Moris 30 weight portions
Ramulus Persicae 30 weight portion Os Canitis 60 weight portion Radix Notoginseng 10 weight portions
Dexamethasone 50 weight portion ibuprofens 30 weight portions
The optimum ratio of pharmaceutical composition of the present invention is:
Radix Aconiti Lateralis Preparata 20 weight portion Radix Aconiti Kusnezoffii 30 weight portion Radix Aconitis 30 weight portions
Rhizoma Zingiberis 25 weight portion Rhizoma Gastrodiaes 20 weight portion Pheretimas 30 weight portions
Bombyx Batryticatus 20 weight portion Scolopendras 25 weight portion Flos Carthamis 20 weight portions
Rhizoma Chuanxiong 20 weight portion Olibanums 25 weight portion Myrrhas 15 weight portions
Caulis Spatholobi 30 weight portion Radix Achyranthis Bidentataes 30 weight portion Rhizoma Arisaematiss 20 weight portions
Semen Sinapis Albae 25 weight portion Radix Saposhnikoviaes 20 weight portion Rhizoma Et Radix Notopterygiis 25 weight portions
Herba Asari 20 weight portion Radix Angelicae Pubescentiss 30 weight portion Radix Gentianae Marcrophyllae 20 weight portions
Fructus Chaenomelis 30 weight portion Radix Clematidis 30 weight portion Herba speranskiae tuberculataes 20 weight portions
Rhizoma Homalomenae 30 weight portion Semen Strychnis 20 weight portion Flos Caryophyllis 40 weight portions
The Rhizoma Cibotii 20 weight portion Cortexs Eucommiae 30 weight portion Rhizoma Drynariae 30 weight portions
Radix Angelicae Sinensis 30 weight portion Flos Daturaes 20 weight portion Pyritums 20 weight portions
Borneolum Syntheticum 25 weight portion Camphoras 40 weight portion Ramulus Moris 20 weight portions
Ramulus Persicae 40 weight portion Os Canitis 40 weight portion Radix Notoginseng 12 weight portions
Dexamethasone 30 weight portion ibuprofens 40 weight portions
The optimum ratio of pharmaceutical composition of the present invention is:
Radix Aconiti Lateralis Preparata 30 weight portion Radix Aconiti Kusnezoffii 20 weight portion Radix Aconitis 20 weight portions
Rhizoma Zingiberis 40 weight portion Rhizoma Gastrodiaes 30 weight portion Pheretimas 20 weight portions
Bombyx Batryticatus 30 weight portion Scolopendras 15 weight portion Flos Carthamis 30 weight portions
Rhizoma Chuanxiong 30 weight portion Olibanums 15 weight portion Myrrhas 25 weight portions
Caulis Spatholobi 20 weight portion Radix Achyranthis Bidentataes 20 weight portion Rhizoma Arisaematiss 30 weight portions
Semen Sinapis Albae 15 weight portion Radix Saposhnikoviaes 30 weight portion Rhizoma Et Radix Notopterygiis 30 weight portions
Herba Asari 30 weight portion Radix Angelicae Pubescentiss 20 weight portion Radix Gentianae Marcrophyllae 30 weight portions
Fructus Chaenomelis 20 weight portion Radix Clematidis 20 weight portion Herba speranskiae tuberculataes 30 weight portions
Rhizoma Homalomenae 20 weight portion Semen Strychnis 30 weight portion Flos Caryophyllis 20 weight portions
The Rhizoma Cibotii 40 weight portion Cortexs Eucommiae 20 weight portion Rhizoma Drynariae 20 weight portions
Radix Angelicae Sinensis 20 weight portion Flos Daturaes 30 weight portion Pyritums 30 weight portions
Borneolum Syntheticum 15 weight portion Camphoras 20 weight portion Ramulus Moris 40 weight portions
Ramulus Persicae 20 weight portion Os Canitis 80 weight portion Radix Notoginseng 8 weight portions
Dexamethasone 70 weight portion ibuprofens 20 weight portions
Described Radix Aconiti Kusnezoffii is a Radix Aconiti Kusnezoffii.
Preparation of drug combination method of the present invention is: according to common process Oleum sesami 500-1500 parts by volume, Plumbum preparatium 150-450 weight portion being tempered into substrate is the A material; With Radix Aconiti Lateralis Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti, Rhizoma Zingiberis, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Scolopendra, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Achyranthis Bidentatae, Rhizoma Arisaematis, Semen Sinapis Albae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Angelicae Pubescentis, Radix Gentianae Marcrophyllae, Fructus Chaenomelis, Radix Clematidis, Herba speranskiae tuberculatae, Rhizoma Homalomenae, Semen Strychni, Flos Caryophylli, Rhizoma Cibotii, the Cortex Eucommiae, Rhizoma Drynariae, Radix Angelicae Sinensis, Flos Daturae, Pyritum, Ramulus Mori, Ramulus Persicae, Os Canitis and Radix Notoginseng coarse pulverization, with 65-85% soak with ethanol 4-10 days, filter liquid storage, medicinal residues add hydrology fire and decoct 1-3 hour, filter liquid storage, the merging of secondary filtrate is condensed into extractum; Olibanum, Myrrha, Borneolum Syntheticum and Camphora ground be fine powder, add extractum and stir evenly, the oven dry mill is that B expects for the above fine powder of 80-120 order then; With dexamethasone, ibuprofen grind for fine powder be C material; Get substrate A material Wen Huahou, the B material is put into substrate A material stir, treat that temperature reduces to 40-60 ℃, C material is put into substrate fully to be stirred evenly and adds propylene glycol 75-225 parts by volume again, laurocapram 15-45 parts by volume, dimethyl sulfoxide (DMSO) 25-75 parts by volume stirs and can spread out into plaster.
Preparation of drug combination method of the present invention is preferably: according to common process Oleum sesami 500 parts by volume, Plumbum preparatium 300 weight portions being tempered into substrate is the A material; With Radix Aconiti Lateralis Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti, Rhizoma Zingiberis, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Scolopendra, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Achyranthis Bidentatae, Rhizoma Arisaematis, Semen Sinapis Albae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Angelicae Pubescentis, Radix Gentianae Marcrophyllae, Fructus Chaenomelis, Radix Clematidis, Herba speranskiae tuberculatae, Rhizoma Homalomenae, Semen Strychni, Flos Caryophylli, Rhizoma Cibotii, the Cortex Eucommiae, Rhizoma Drynariae, Radix Angelicae Sinensis, Flos Daturae, Pyritum, Ramulus Mori, Ramulus Persicae, Os Canitis and Radix Notoginseng coarse pulverization, with 75% soak with ethanol 7 days, filter liquid storage, medicinal residues add hydrology fire and decoct 2 hours, filter liquid storage, the merging of secondary filtrate is condensed into cream; Olibanum, Myrrha, Borneolum Syntheticum and Camphora ground be fine powder, add stiff paste and stir evenly, the oven dry mill is that the above fine powder of 100 orders is that B expects then; With dexamethasone, ibuprofen grind for fine powder be C material; Get substrate A material Wen Huahou, the B material is put into substrate A material stir, treat that temperature reduces to 50 ℃, C material is put into substrate fully to be stirred evenly and adds propylene glycol 150 parts by volume again, laurocapram 30 parts by volume, dimethyl sulfoxide (DMSO) 50 parts by volume stir and can spread out into plaster.
The pass of weight portion and parts by volume is a grams per milliliter.
Drug composition of the present invention adds conventional adjuvant is made clinical acceptance according to common process dosage form by practice of pharmacy.Described dosage form is emplastrum, ointment, spray, powder, tincture etc.
Pharmaceutical composition of the present invention has the compressing stimulation of alleviation to tissues such as nerve root, blood vessels, strengthen and improve local blood circulation, enhance metabolism, strengthen adhesion around tension force, elastic force and tolerance, blood circulation promoting and dispersing pathogen accumulation, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, the releasing muscle spasm of muscle, the joint of loosening, contraction is assisted in elimination tendon, ligament, joint, recover the range of extension in joint, easing joint movement, the muscle arteries and veins is unfolded, and QI and blood is unobstructed, reaches the purpose of treatment ankylosis.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The present invention's " hot plaster of Xinhua " has treated neck, lumbar spondylosis, waist, skelalgia 156 routine curative effects since 2002 very satisfied, is reported as follows:
1, clinical data
This organizes 156 examples: male 92 examples, women 64 examples, the oldest person 81 years old, minimum year person 19 years old, the elder of the course of disease 2 years, the shortest person 6 days, X sheet, CT sheet, MRL sheet, maneuver diagnosis nervous system type cervical spondylosis 46 examples, vertebral artery type of cervical spondylosis 22 examples, lumbar intervertebral disc 4,5 vertebras are given prominence to 35 examples, numb 22 examples of lower limb pain, lumbago, skelalgia of rheumatism 21 examples.
2, Therapeutic Method:
2.1 Therapeutic Principle: relieving spasm to stop pain, blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral
2.2 experimental drug of the present invention is the plaster that the present composition is made.
3, criterion of therapeutical effect
3.1 stipulate about neck, waist, skelalgia efficacy criteria in " Chinese medicine disease diagnosis criterion of therapeutical effect " with reference to State Administration of Traditional Chinese Medicine's promulgation:
Cure: think that symptom and positive reaction thing all disappear, the activity of neck waist freely, limbs stretch freely, the recovery normal physiological function.
Take a turn for the better: subjective symptoms alleviates, and positive reaction slightly improves.
Difference: subjective symptoms does not have improvement, and positive reaction still exists.
3.2 therapeutic outcome: cure 109 examples among the 156 routine patients, maximum duration 2 months accounted for 76% in the shortest 6 days, and 31 examples that take a turn for the better account for 21.8%, differ from 3 examples and account for 2%, total effective rate 98%.
4, model case
Case 1: open * *, the male, 44 years old, waist station, Pingyuan County street peasant, in first visit on April 6 in 2006, the private prosecution lumbago several months, pitching was difficult, can not work, and does not imitate through integrative therapy.Be diagnosed as three, four hyperosteogeny and fifth lumbar vertebra sacrumization in the inspection of county hospital X-ray photograph, transfer my institute's treatment, waist is tetanic at this moment, aching can not pitching.Look into: the pulse condition jewelry, expensive clothing and other valuables are unable, pale tongue, white and thin fur.Treatment: get the gate of vitality, yao yang kuan cave, with ethanol the acupuncture point is wiped several times, thermotherapy plaster Wen Huahou is sticked 3 days 3 nights, for the second time yao yang kuan the 3rd, five lumbar vertebras are rubbed with the hands several times with wipes of alcohol, Wen Huahou sticks then, stick two Weizhong points simultaneously, application treatment 15 days, lumbago is alleviated, but still feel tired out, sticked all transference cures again 30 days, pitching freely muscle power and action just like at ordinary times, and again through the county hospital X-ray examination: three, the equal complete obiteration of the disease of four hyperosteogeny and fifth lumbar vertebra sacrumization recovers normal.
Case 2: the king * *, man, 46 years old, the cadre of the Pingyuan County tax bureau, examine on August 9th, 2006,2 days causes of private prosecution are moved article and are sprained waist and cause flank pain, change one's position, the pitching difficulty, and waist can not stretch when standing, unit hospitalize once, effect do not show, so change my institute's treatment.Look into: hale and hearty usually, for very, local little swollen, the pressure that press at the SHENYU acupoint place is obviously painful with the left side for flank pain, and is sick by bearing a heavy burden excessively, the damage passages through which vital energy circulates, and through the imbalance of fate row, stagnation of QI-blood is due to the part.Control and get in shen shu, the committee.Rub with the hands several times with wipes of alcohol in (two cave), and thermotherapy plaster temperatureization is sticked on the acupuncture point.The next afternoon patient feels that promptly waist changes pine and can do the pitching activity.
Case 3: Liu * *, the man, 50 years old, Pingyuan County Yao Zhan town Geng Lou village village's document, the patient is diagnosed as cervical spondylotic radiculopathy in county people's hospital and Liaocheng City the People's Hospital, the right eye blurring of vision, right arm can not lift.Substantially disappear through three days symptoms of the invention that loses money in a business " the hot plaster of Xinhua ", paste three days its symptoms again and all disappear.
Case 4: Song *, the man, 30 years old, the lathe workman is the big extension of Pingyuan County king paper mill, because of frequent pain in the lumbar region, at the CT of provincial hospital diagnosis spinal column curvature lateral bending, through add again with the present invention's " hot plaster of Xinhua " functional exercise after six days pain obviously alleviate, pasted again six days, symptom all disappears, and has recovered normal through county hospital CT sheet demonstration spinal column curvature.
Case 5: Lee * *, the woman, 51 years old, Pingyuan County Xiao Xin people from village, a right arm pain wheat harvesting period unbearably can not be lifted and combs one's hair, examine through county hospital to be " scapulohumeral periarthritis ", through the invention that loses money in a business " the hot plaster of Xinhua " after seven days symptom disappear substantially, functional rehabilitation is normal.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1:
Radix Aconiti Lateralis Preparata 26kg Radix Aconiti Kusnezoffii 26kg Radix Aconiti 26kg Rhizoma Zingiberis 30kg
Rhizoma Gastrodiae 26kg Pheretima 26kg Bombyx Batryticatus 26kg Scolopendra 20kg
Flos Carthami 26kg Rhizoma Chuanxiong 26kg Olibanum 20kg Myrrha 20kg
Caulis Spatholobi 26kg Radix Achyranthis Bidentatae 26kg Rhizoma Arisaematis 26kg Semen Sinapis Albae 20kg
Radix Saposhnikoviae 26kg Rhizoma Et Radix Notopterygii 26kg Herba Asari 26kg Radix Angelicae Pubescentis 26kg
Radix Gentianae Marcrophyllae 26kg Fructus Chaenomelis 26kg Radix Clematidis 26kg Herba speranskiae tuberculatae 26kg
Rhizoma Homalomenae 26kg Semen Strychni 26kg Flos Caryophylli 30kg Rhizoma Cibotii 30kg
Cortex Eucommiae 26kg Rhizoma Drynariae 26kg Radix Angelicae Sinensis 26kg Flos Daturae 26kg
Pyritum 26kg Borneolum Syntheticum 20kg Camphora 30kg Ramulus Mori 30kg
Ramulus Persicae 30kg Os Canitis 60kg Radix Notoginseng 10kg
Dexamethasone 50kg ibuprofen 30kg
According to common process Oleum sesami 500kg, Plumbum preparatium 300kg being tempered into substrate is the A material; With Radix Aconiti Lateralis Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti, Rhizoma Zingiberis, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Scolopendra, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Achyranthis Bidentatae, Rhizoma Arisaematis, Semen Sinapis Albae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Angelicae Pubescentis, Radix Gentianae Marcrophyllae, Fructus Chaenomelis, Radix Clematidis, Herba speranskiae tuberculatae, Rhizoma Homalomenae, Semen Strychni, Flos Caryophylli, Rhizoma Cibotii, the Cortex Eucommiae, Rhizoma Drynariae, Radix Angelicae Sinensis, Flos Daturae, Pyritum, Ramulus Mori, Ramulus Persicae, Os Canitis and Radix Notoginseng coarse pulverization, with 75% soak with ethanol 7 days, filter liquid storage, medicinal residues add hydrology fire and decoct 2 hours, filter liquid storage, the merging of secondary filtrate is condensed into cream; Olibanum, Myrrha, Borneolum Syntheticum and Camphora ground be fine powder, add stiff paste and stir evenly, the oven dry mill is that the above fine powder of 100 orders is that B expects then; With dexamethasone 50kg, ibuprofen 30kg grind for fine powder be C material; Get substrate A material Wen Huahou, the B material is put into substrate A material stir, treat that temperature reduces to 50 ℃, C material is put into substrate fully to be stirred evenly and adds propylene glycol 1501 again, laurocapram 301, dimethyl sulfoxide (DMSO) 501 stirs and can spread out into plaster, be spread out on the non-woven fabrics of 12cm * 12cm, find the pain point accurately, the affected part is wiped clean with wine, be attached to the plaster back side on the hot water cup boiling hot soft, sticked 6 days, one month is a course of treatment.
Embodiment 2:
Radix Aconiti Lateralis Preparata 20kg Radix Aconiti Kusnezoffii 30kg Radix Aconiti 30kg Rhizoma Zingiberis 25kg
Rhizoma Gastrodiae 20kg Pheretima 30kg Bombyx Batryticatus 20kg Scolopendra 25kg
Flos Carthami 20kg Rhizoma Chuanxiong 20kg Olibanum 25kg Myrrha 15kg
Caulis Spatholobi 30kg Radix Achyranthis Bidentatae 30kg Rhizoma Arisaematis 20kg Semen Sinapis Albae 25kg
Radix Saposhnikoviae 20kg Rhizoma Et Radix Notopterygii 25kg Herba Asari 20kg Radix Angelicae Pubescentis 30kg
Radix Gentianae Marcrophyllae 20kg Fructus Chaenomelis 30kg Radix Clematidis 30kg Herba speranskiae tuberculatae 20kg
Rhizoma Homalomenae 30kg Semen Strychni 20kg Flos Caryophylli 40kg Rhizoma Cibotii 20kg
Cortex Eucommiae 30kg Rhizoma Drynariae 30kg Radix Angelicae Sinensis 30kg Flos Daturae 20kg
Pyritum 20kg Borneolum Syntheticum 25kg Camphora 40kg Ramulus Mori 20kg
Ramulus Persicae 40kg Os Canitis 40kg Radix Notoginseng 12kg dexamethasone 30kg
Ibuprofen 40kg
Said medicine technology routinely adds conventional adjuvant and makes spray.
Embodiment 3:
Radix Aconiti Lateralis Preparata 30kg Radix Aconiti Kusnezoffii 20kg Radix Aconiti 20kg Rhizoma Zingiberis 40kg
Rhizoma Gastrodiae 30kg Pheretima 20kg Bombyx Batryticatus 30kg Scolopendra 15kg
Flos Carthami 30kg Rhizoma Chuanxiong 30kg Olibanum 15kg Myrrha 25kg
Caulis Spatholobi 20kg Radix Achyranthis Bidentatae 20kg Rhizoma Arisaematis 30kg Semen Sinapis Albae 15kg
Radix Saposhnikoviae 30kg Rhizoma Et Radix Notopterygii 30kg Herba Asari 30kg Radix Angelicae Pubescentis 20kg
Radix Gentianae Marcrophyllae 30kg Fructus Chaenomelis 20kg Radix Clematidis 20kg Herba speranskiae tuberculatae 30kg
Rhizoma Homalomenae 20kg Semen Strychni 30kg Flos Caryophylli 20kg Rhizoma Cibotii 40kg
Cortex Eucommiae 20kg Rhizoma Drynariae 20kg Radix Angelicae Sinensis 20kg Flos Daturae 30kg
Pyritum 30kg Borneolum Syntheticum 15kg Camphora 20kg Ramulus Mori 40kg
Ramulus Persicae 20kg Os Canitis 80kg Radix Notoginseng 8kg dexamethasone 70kg
Ibuprofen 20kg
Said medicine technology routinely adds conventional adjuvant and makes ointment.
Claims (10)
1. pharmaceutical composition for the treatment of cervical spondylosis and lumbago and skelalgia is characterized in that the crude drug of said composition consists of:
Radix Aconiti Lateralis Preparata 13-39 weight portion Radix Aconiti Kusnezoffii 13-39 weight portion Radix Aconiti 13-39 weight portion
Rhizoma Zingiberis 15-45 weight portion Rhizoma Gastrodiae 13-39 weight portion Pheretima 13-39 weight portion
Bombyx Batryticatus 13-39 weight portion Scolopendra 10-30 weight portion Flos Carthami 13-39 weight portion
Rhizoma Chuanxiong 13-39 weight portion Olibanum 10-30 weight portion Myrrha 10-30 weight portion
Caulis Spatholobi 13-39 weight portion Radix Achyranthis Bidentatae 13-39 weight portion Rhizoma Arisaematis 13-39 weight portion
Semen Sinapis Albae 10-30 weight portion Radix Saposhnikoviae 13-39 weight portion Rhizoma Et Radix Notopterygii 13-39 weight portion
Herba Asari 13-39 weight portion Radix Angelicae Pubescentis 13-39 weight portion Radix Gentianae Marcrophyllae 13-39 weight portion
Fructus Chaenomelis 13-39 weight portion Radix Clematidis 13-39 weight portion Herba speranskiae tuberculatae 13-39 weight portion
Rhizoma Homalomenae 13-39 weight portion Semen Strychni 13-39 weight portion Flos Caryophylli 15-45 weight portion
Rhizoma Cibotii 15-45 weight portion Cortex Eucommiae 13-39 weight portion Rhizoma Drynariae 13-39 weight portion
Radix Angelicae Sinensis 13-39 weight portion Flos Daturae 13-39 weight portion Pyritum 13-39 weight portion
Borneolum Syntheticum 10-30 weight portion Camphora 15-45 weight portion Ramulus Mori 15-45 weight portion
Ramulus Persicae 15-45 weight portion Os Canitis 30-90 weight portion Radix Notoginseng 5-15 weight portion
Dexamethasone 25-75 weight portion ibuprofen 15-45 weight portion.
2. pharmaceutical composition according to claim 1 is characterized in that the crude drug of said composition consists of:
Radix Aconiti Lateralis Preparata 26 weight portion Radix Aconiti Kusnezoffii 26 weight portion Radix Aconitis 26 weight portions
Rhizoma Zingiberis 30 weight portion Rhizoma Gastrodiaes 26 weight portion Pheretimas 26 weight portions
Bombyx Batryticatus 26 weight portion Scolopendras 20 weight portion Flos Carthamis 26 weight portions
Rhizoma Chuanxiong 26 weight portion Olibanums 20 weight portion Myrrhas 20 weight portions
Caulis Spatholobi 26 weight portion Radix Achyranthis Bidentataes 26 weight portion Rhizoma Arisaematiss 26 weight portions
Semen Sinapis Albae 20 weight portion Radix Saposhnikoviaes 26 weight portion Rhizoma Et Radix Notopterygiis 26 weight portions
Herba Asari 26 weight portion Radix Angelicae Pubescentiss 26 weight portion Radix Gentianae Marcrophyllae 26 weight portions
Fructus Chaenomelis 26 weight portion Radix Clematidis 26 weight portion Herba speranskiae tuberculataes 26 weight portions
Rhizoma Homalomenae 26 weight portion Semen Strychnis 26 weight portion Flos Caryophyllis 30 weight portions
The Rhizoma Cibotii 30 weight portion Cortexs Eucommiae 26 weight portion Rhizoma Drynariae 26 weight portions
Radix Angelicae Sinensis 26 weight portion Flos Daturaes 26 weight portion Pyritums 26 weight portions
Borneolum Syntheticum 20 weight portion Camphoras 30 weight portion Ramulus Moris 30 weight portions
Ramulus Persicae 30 weight portion Os Canitis 60 weight portion Radix Notoginseng 10 weight portions
Dexamethasone 50 weight portion ibuprofens 30 weight portions.
3. pharmaceutical composition according to claim 1 is characterized in that the crude drug of said composition consists of:
Radix Aconiti Lateralis Preparata 20 weight portion Radix Aconiti Kusnezoffii 30 weight portion Radix Aconitis 30 weight portions
Rhizoma Zingiberis 25 weight portion Rhizoma Gastrodiaes 20 weight portion Pheretimas 30 weight portions
Bombyx Batryticatus 20 weight portion Scolopendras 25 weight portion Flos Carthamis 20 weight portions
Rhizoma Chuanxiong 20 weight portion Olibanums 25 weight portion Myrrhas 15 weight portions
Caulis Spatholobi 30 weight portion Radix Achyranthis Bidentataes 30 weight portion Rhizoma Arisaematiss 20 weight portions
Semen Sinapis Albae 25 weight portion Radix Saposhnikoviaes 20 weight portion Rhizoma Et Radix Notopterygiis 25 weight portions
Herba Asari 20 weight portion Radix Angelicae Pubescentiss 30 weight portion Radix Gentianae Marcrophyllae 20 weight portions
Fructus Chaenomelis 30 weight portion Radix Clematidis 30 weight portion Herba speranskiae tuberculataes 20 weight portions
Rhizoma Homalomenae 30 weight portion Semen Strychnis 20 weight portion Flos Caryophyllis 40 weight portions
The Rhizoma Cibotii 20 weight portion Cortexs Eucommiae 30 weight portion Rhizoma Drynariae 30 weight portions
Radix Angelicae Sinensis 30 weight portion Flos Daturaes 20 weight portion Pyritums 20 weight portions
Borneolum Syntheticum 25 weight portion Camphoras 40 weight portion Ramulus Moris 20 weight portions
Ramulus Persicae 40 weight portion Os Canitis 40 weight portion Radix Notoginseng 12 weight portions
Dexamethasone 30 weight portion ibuprofens 40 weight portions.
4. pharmaceutical composition according to claim 1 is characterized in that the crude drug of said composition consists of:
Radix Aconiti Lateralis Preparata 30 weight portion Radix Aconiti Kusnezoffii 20 weight portion Radix Aconitis 20 weight portions
Rhizoma Zingiberis 40 weight portion Rhizoma Gastrodiaes 30 weight portion Pheretimas 20 weight portions
Bombyx Batryticatus 30 weight portion Scolopendras 15 weight portion Flos Carthamis 30 weight portions
Rhizoma Chuanxiong 30 weight portion Olibanums 15 weight portion Myrrhas 25 weight portions
Caulis Spatholobi 20 weight portion Radix Achyranthis Bidentataes 20 weight portion Rhizoma Arisaematiss 30 weight portions
Semen Sinapis Albae 15 weight portion Radix Saposhnikoviaes 30 weight portion Rhizoma Et Radix Notopterygiis 30 weight portions
Herba Asari 30 weight portion Radix Angelicae Pubescentiss 20 weight portion Radix Gentianae Marcrophyllae 30 weight portions
Fructus Chaenomelis 20 weight portion Radix Clematidis 20 weight portion Herba speranskiae tuberculataes 30 weight portions
Rhizoma Homalomenae 20 weight portion Semen Strychnis 30 weight portion Flos Caryophyllis 20 weight portions
The Rhizoma Cibotii 40 weight portion Cortexs Eucommiae 20 weight portion Rhizoma Drynariae 20 weight portions
Radix Angelicae Sinensis 20 weight portion Flos Daturaes 30 weight portion Pyritums 30 weight portions
Borneolum Syntheticum 15 weight portion Camphoras 20 weight portion Ramulus Moris 40 weight portions
Ramulus Persicae 20 weight portion Os Canitis 80 weight portion Radix Notoginseng 8 weight portions
Dexamethasone 70 weight portion ibuprofens 20 weight portions.
5. according to the described pharmaceutical composition of one of claim 1-4, it is characterized in that described Radix Aconiti Kusnezoffii is a Radix Aconiti Kusnezoffii.
6. preparation of drug combination method according to claim 5 is characterized in that this preparation method is: according to common process Oleum sesami 500-1500 parts by volume, Plumbum preparatium 150-450 weight portion being tempered into substrate is the A material; With Radix Aconiti Lateralis Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti, Rhizoma Zingiberis, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Scolopendra, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Achyranthis Bidentatae, Rhizoma Arisaematis, Semen Sinapis Albae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Angelicae Pubescentis, Radix Gentianae Marcrophyllae, Fructus Chaenomelis, Radix Clematidis, Herba speranskiae tuberculatae, Rhizoma Homalomenae, Semen Strychni, Flos Caryophylli, Rhizoma Cibotii, the Cortex Eucommiae, Rhizoma Drynariae, Radix Angelicae Sinensis, Flos Daturae, Pyritum, Ramulus Mori, Ramulus Persicae, Os Canitis and Radix Notoginseng coarse pulverization, with 65-85% soak with ethanol 4-10 days, filter liquid storage, medicinal residues add hydrology fire and decoct 1-3 hour, filter liquid storage, the merging of secondary filtrate is condensed into cream; Olibanum, Myrrha, Borneolum Syntheticum and Camphora ground be fine powder, add stiff paste and stir evenly, the oven dry mill is the B material for 80-120 order fine powder then; With dexamethasone, ibuprofen grind for fine powder be C material; Get substrate A material Wen Huahou, the B material is put into substrate A material stir, treat that temperature reduces to 40-60 ℃, C material is put into substrate fully to be stirred evenly and adds propylene glycol 75-225 parts by volume again, laurocapram 15-45 parts by volume, dimethyl sulfoxide 25-75 parts by volume stirs and can spread out into plaster.
7. preparation of drug combination method according to claim 6 is characterized in that this preparation method is: according to common process Oleum sesami 500 parts by volume, Plumbum preparatium 300 weight portions being tempered into substrate is the A material; With Radix Aconiti Lateralis Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti, Rhizoma Zingiberis, Rhizoma Gastrodiae, Pheretima, Bombyx Batryticatus, Scolopendra, Flos Carthami, Rhizoma Chuanxiong, Caulis Spatholobi, Radix Achyranthis Bidentatae, Rhizoma Arisaematis, Semen Sinapis Albae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Asari, Radix Angelicae Pubescentis, Radix Gentianae Marcrophyllae, Fructus Chaenomelis, Radix Clematidis, Herba speranskiae tuberculatae, Rhizoma Homalomenae, Semen Strychni, Flos Caryophylli, Rhizoma Cibotii, the Cortex Eucommiae, Rhizoma Drynariae, Radix Angelicae Sinensis, Flos Daturae, Pyritum, Ramulus Mori, Ramulus Persicae, Os Canitis and Radix Notoginseng coarse pulverization, with 75% soak with ethanol 7 days, filter liquid storage, medicinal residues add hydrology fire and decoct 2 hours, filter liquid storage, the merging of secondary filtrate is condensed into cream; Olibanum, Myrrha, Borneolum Syntheticum and Camphora ground be fine powder, add stiff paste and stir evenly, the oven dry mill is that the above fine powder of 100 orders is that B expects then; With dexamethasone, ibuprofen grind for fine powder be C material; Get substrate A material Wen Huahou, the B material is put into substrate A material stir, treat that temperature reduces to 50 ℃, the C material is put into substrate fully stir evenly and add propylene glycol 150 parts by volume again, laurocapram 30 parts by volume, dimethyl sulfoxide 50 parts by volume stir and can spread out into plaster.
8. pharmaceutical composition according to claim 5 is characterized in that said composition adds conventional adjuvant is made clinical acceptance according to common process dosage form by practice of pharmacy.
9. pharmaceutical composition according to claim 8 is characterized in that the made dosage form of said composition is emplastrum, ointment, spray, powder or tincture.
10. according to the application of the described pharmaceutical composition of one of claim 1-4 in the medicine of preparation treatment cervical spondylosis, lumbar spondylosis or lumbago and skelalgia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100640012A CN101244247B (en) | 2007-02-16 | 2007-02-16 | Pharmaceutical combination for treating cervical vertebra disease and waist and leg pain, and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100640012A CN101244247B (en) | 2007-02-16 | 2007-02-16 | Pharmaceutical combination for treating cervical vertebra disease and waist and leg pain, and preparation thereof |
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| Publication Number | Publication Date |
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| CN101244247A CN101244247A (en) | 2008-08-20 |
| CN101244247B true CN101244247B (en) | 2010-10-13 |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972376B (en) * | 2010-09-29 | 2012-09-05 | 韩世昌 | Chinese medicinal ointment for treating intervertebral disc hyperosteogeny and preparation method thereof |
| CN102008666B (en) * | 2010-11-30 | 2012-03-21 | 赵柏英 | Drug for treating lumbocrural pain |
| CN102648950B (en) * | 2012-04-20 | 2014-05-14 | 贵州省铜仁梵天生物科技有限责任公司 | Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains |
| CN102671045B (en) * | 2012-05-09 | 2014-07-02 | 王艳和 | Chinese medicinal composition for treating prolapse of lumbar intervertebral disc |
| CN102755537B (en) * | 2012-06-28 | 2014-03-26 | 李伟 | External Chinese patent medicine for treating lumbocrural pains and application of external Chinese patent medicine |
| CN103446407B (en) * | 2013-08-21 | 2016-06-29 | 兰州善元和蒸熏研究所 | A kind of pure Chinese medicinal preparation treating cervical and lumbar diseases and fumigant thereof |
| CN103610944A (en) * | 2013-11-28 | 2014-03-05 | 高鑫 | Blood circulation promoting and blood stasis removing wine |
| CN104688860A (en) * | 2013-12-04 | 2015-06-10 | 陈梦慰 | Cervical vertebrae plaster |
| CN103961510A (en) * | 2014-05-26 | 2014-08-06 | 严雪峰 | Hot paste liquid for treating hyperostosis and lumbar disc herniation and preparation method thereof |
| CN105497435A (en) * | 2014-11-26 | 2016-04-20 | 杨维兵 | Traditional Chinese medicine for treating terminal diseases of multiple tendines |
| CN105709021A (en) * | 2016-03-14 | 2016-06-29 | 张春荣 | Muscle and bone recovery unguent and preparation method thereof |
| CN107802814A (en) * | 2017-12-05 | 2018-03-16 | 许国语 | Chinese medicine composition and its manufactured plaster and preparation method |
| CN108310331A (en) * | 2018-05-08 | 2018-07-24 | 葛新军 | A kind of the external application medical ointment formula and preparation method and application of analgesic |
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