CN103736038A - Chinese medicine combination for curing leukemia, preparation and application thereof - Google Patents
Chinese medicine combination for curing leukemia, preparation and application thereof Download PDFInfo
- Publication number
- CN103736038A CN103736038A CN201410056222.5A CN201410056222A CN103736038A CN 103736038 A CN103736038 A CN 103736038A CN 201410056222 A CN201410056222 A CN 201410056222A CN 103736038 A CN103736038 A CN 103736038A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- preparation
- rhizoma
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a Chinese medicine combination for curing leukemia and a preparation and application thereof. The combination is prepared from the following ingredients in a proper ratio: hedyotic diffusa, indigo, prepared rhizome of rehmannia, eclipta alba, drynaria rhizome, dogwood, atratylodes rhizome, Chinese magnoliavine fruit, ginseng, astragalus, angelica, donkey-hide gelatin, rheum officinale, pseudo-ginseng, curcuma zedoary, earthworm, cortex moutan, radix bupleuri, turtle shell and oyster. The drug which is prepared from the combination has accurate curative effects. The raw materials are common Chinese medicines which are safe and effective. Both the hemogram and the symptom of early and middle leukemia patients taking the drug for about ten days can be improved, the disease is controlled after one to three months, the leukemia is cured after half a year to one year more or less, and relapse cannot occur after the drug is stopped. The hemogram of late patients can also be improved and stabilized, complications are alleviated or eliminated, pain is relieved, life quality is improved, and the life is prolonged.
Description
Technical field
The present invention relates to field of medicaments, in particular to a kind of, treat leukemic Chinese medicine composition, its preparation and application.
Background technology
Leukemia is the abnormal clone's property malignant disease of a class hematopoietic stem cell.Be divided into clinically acute lymphoblastic leukemia, acute myelocytic leukemia; Chronic myelocytic leukemia, chronic lymphocytic leukemia etc.
The leukemic cause of disease, Western medicine diagnose causes for viral factor, chemical factor, radiation factor and inherited genetic factors.The traditional Chinese medical science think due to the absurd row of heat in blood forcing blood or deficiency of kidney-YIN or epidemic febrile disease enter in, pathogenic heat cave in etc. because of become.
The clinical visible anemia in various degree of leukemia, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pain, blood testing, granulocyte, lymphocyte, leukocyte or high or low; Erythrocyte, hemoglobin, platelet all decline and reduce etc.Face in card, have again the large-scale leukemia of hepatosplenomegaly type and the enlargement of lymph node.Its pathogenesis is asthenia of both the spleen and kidney, the resistance of stagnation of liver-QI network, and virus enters blood, makes hemocyte variation propagation, infiltrates other histiocyte, destroys hemopoietic system, and infringement hemopoietic function, goes down hemopoietic function; Unhygienic diet, dirty stifled marrow key, causes hematopoietic disorders, forms aplastic anemia leukemia.
At present, medical profession is to leukemic treatment, doctor trained in Western medicine method for the treatment of: change Bone Marrow Treatment, chemotherapy, radiotherapy, targeted therapy, immunization therapy etc.Can have a curative effect, but change Bone Marrow Treatment, join type difficulty, and involve great expense; And chemotherapeutics treatment is painful, there are again many side effect, as kill and wound, suppress normal hematopoiesis cell, suppress normal immunologic function, immunity of organisms declines, and easily merges various infection; Injure gastrointestinal tract mucously, cause that anorexia is felt sick, vomiting, affect darling renal function, chemotherapeutics also can make the second Tumor incidence increase in addition.Moreover, then heavy dose also can not be killed the leukaemia in body, the root of always palindromia of residual leukaemia completely.The Traditional Chinese Medicine rule for the treatment of: intend Chinese prescription for oral administration, benefiting qi and nourishing blood, regulates negative and positive, clearing away heat and cooling blood, eliminating fire and detoxication, hemostasis etc.Though can protect the recovery of normal hematopoiesis function and bone marrow, prevent that chemotherapeutics from causing serious bone marrow transplantation, reduce blood transfusion, reduce hemorrhage; Promote the recovery of normal immunologic function, reduce and infect complication, but curative effect is also undesirable, therapy of combining Chinese and Western medicine, curative effect is slightly good, still inconsiderable.
Summary of the invention
One of object of the present invention, is to provide a kind of determined curative effect, safe and reliable Chinese medicine composition, to solve the above problems.
The technical scheme adopting is: a kind ofly treat leukemic Chinese medicine composition, the raw material of following weight portion, consist of:
Herba Hedyotidis Diffusae 15-25 part, Indigo Naturalis 15-25 part, Radix Rehmanniae Preparata 15-25 part, Herba Ecliptae 15-25 part, Rhizoma Drynariae 10-20 part, Fructus Corni 5-15 part, Rhizoma Atractylodis 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Radix Ginseng 10-20 part, Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Colla Corii Asini 15-25 part, Radix Et Rhizoma Rhei 5-15 part, Radix Notoginseng 5-15 part, Rhizoma Curcumae 5-15 part, Pheretima 5-15 part, Cortex Moutan 5-15 part, Radix Bupleuri 5-15 part, Carapax Trionycis 10-20 part, Concha Ostreae 10-20 part.
In the present invention, Herba Hedyotidis Diffusae is that herb, the Indigo Naturalis (Indigo naturalis) of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae (Hedyotis diffusa) is the dry pigment in dicotyledon medicine acanthaceous vegetable acanthaceous indigo, dicotyledon medicine leguminous plant Folium et Caulis Indigoferae Tinctoriae, dicotyledon medicine cruciferae isatis, careless Folium Isatidis or polygonaceae plant polygonum tinctorium ait. leaf, these two kinds of raw materials act as detoxicating, killing bacteria in compositions, inhibition and elimination leukaemia's is the monarch drug in this prescription;
When being classified as the root of Umbelliferae angelica herbaceous plant Radix Angelicae Sinensis (Angelica sinensis), Rhizoma Curcumae is Zingiberaceae curcuma Rhizoma Curcumae (Curcuma zedoaria(Christm.) Rosc.) rhizome, Cortex Moutan is the root bark of Ranunculaceae Paeonia plant Paeonia suffruticosa (Paeonia suffruticosa Andr.), Radix Bupleuri is the root of umbelliferae bupleurum (Bupleurum chinense), Carapax Trionycis is the carapace of Trionychidae animal Trionyx sinensis Wiegmann (Trionyx sinensis Wiegmann), Concha Ostreae is Ostreidae (the true Concha Ostreae of Ostreidae) Huo Yan clam section (Aviculidae pearl oyster) animal body, the effect of these several raw materials is clearing away heat and cooling blood, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral, hard masses softening and resolving, auxiliary monarch drug is eliminating evil, for the ministerial drug in this prescription,
Radix Rehmanniae Preparata is scrophulariaceae rehmannia glutinosa plant (formal name used at school: root Rehmannia glutinosa), Herba Ecliptae is the aerial parts of feverfew Eclipta prostrata (Eclipta prostrata L.), Rhizoma Drynariae is Davalliaceae (Davalliaceae) plant great Ye Rhizoma Drynariae, the rhizome of the plants such as Rhizoma Drynariae, Fructus Corni is the sarcocarp of Cornaceae plant Fructus Corni (Cornus.officinalis), Rhizoma Atractylodis are the rhizome of Compositae [WTBX plant Rhizoma Atractylodis (Atractylodes lancea), Fructus Schisandrae Chinensis is the fruit of Schisandraceae Plant Fructus Schisandrae Chinensis (Schisandra chinensis), Radix Ginseng is the root of Araliaceae Radix Ginseng (Panax ginseng), the Radix Astragali is the root of the leguminous plant Radix Astragali (Astragalus membranaceus (Fisch.) Bunge.), Colla Corii Asini is the solid animal glue after donkey skin decocting and concentrating, Radix Notoginseng is the root of panax araliaceae plant (Panax pseudoginseng Wall.var.notoginseng (Burkill) Hoo et Tseng), the effect of these several raw materials is kidney and spleen invigoratings, benefiting QI and nourishing blood, hold back liver hemostasis, strengthening the body resistance, increase the eliminating evil power of monarch drug, for the adjuvant drug in this prescription,
Radix Et Rhizoma Rhei is the rhizome of polygonaceae plant Radix Et Rhizoma Rhei (Rheum palmatum L.), the animal Pheretima aspergillum Pheretimaas pergilum of Pheretima Wei Ju earthworm section (E Perrier), popular Pheretimatschiliensis P vulgarisChen, William Pheretimatschiliensis P guillelmi (Michaelsen) or comb the region between the heart and the diaphragm hair earthworm P pectiniferaMichaelsen's is all, the effect of these two kinds of raw materials be tonneau two just, blowdown block removing, in order to hemopoietic, it is the medicine that makes in this prescription.
Present inventor uses Chinese medical theory, selects suitable raw material and ratio, obtains above-mentioned Chinese medicine composition.Mutually collaborative between these raw materials, by the kidney invigorating hemopoietic, strong the spleen governs the blood, hold back liver hemostasis, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral, clearing away heat and cooling blood, hard masses softening and resolving, detoxicating, killing bacteria, detumescence blowdown, block removing hemopoietic, and the softening approach that dwindles or eliminate liver spleen and lymphadenectasis is treated leukemia; Determined curative effect, various raw materials are all common Chinese medicine, safe and effective.To leukaemia's growth, expansion, and the caused anemia of leukemia, hemorrhage, infectious fever regulating liver-QI, spleen, lymphadenectasis, the symptom of skeleton pain can be controlled or eliminate; Can also regulate, stabilized leukocyte height and erythrocyte, hemoglobin, thrombocytopenia, make it to tend to normal recovery, or rehabilitation is normal.Leukemia early, mid-term patient, take medicine about 10 days, hemogram and disease all can be improved, and within 1-3 month, control the state of an illness, about half a year to 1 year, cure, drug withdrawal is not recurred.Patients with terminal, also can improve and stable hemogram, alleviates or eliminates complication, solves misery, improves the quality of living, and delays life.
As preferred technical scheme: a kind ofly treat leukemic Chinese medicine composition, formed by the raw material of following weight portion:
20 parts of Herba Hedyotidis Diffusaes, 20 parts of Indigo Naturaliss, 20 parts, Radix Rehmanniae Preparata, 20 parts of Herba Ecliptaes, 15 parts of Rhizoma Drynariae, 10 parts of Fructus Corni, 10 parts of Rhizoma Atractylodis, 10 parts of Fructus Schisandrae Chinensis, 15 parts of Radix Ginsengs, 15 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts, Colla Corii Asini, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Notoginseng, 10 parts of Rhizoma Curcumae, 10 parts of Pheretimas, 10 parts of Cortex Moutans, 10 parts of Radix Bupleuri, 15 parts of Carapax Trionycis, 15 parts of Concha Ostreaes.
Clinical trial proves, adopts such ratio, treats leukemic better effects if.
Two of object of the present invention, is to provide the acceptable preparation clinically that adopts above-mentioned compositions to make.
As preferred scheme: described preparation is capsule.Capsule taking convenience, easy to make.
The preparation method of above-mentioned capsule is: by after raw material baking, pulverize, cross 80 mesh sieves, obtain medicated powder, described medicated powder is incapsulated in shell, obtain.
As preferred technical scheme, in above-mentioned preparation method, baking temperature is 220-240 ℃, and baking time is 15-25min.Such temperature and time, can guarantee fully to retain effective ingredient, is beneficial to curative effect.
As preferred technical scheme: described preparation is pill.Pill preparation is simple, and preparation cost is low.
The preparation method of above-mentioned pill: by after raw material baking, pulverize, cross 80 mesh sieves, obtain medicated powder, add binding agent mix homogeneously in described medicated powder, be then pressed into pill, obtain.
As preferred technical scheme, to prepare in the process of pill, baking temperature is 220-240 ℃, baking time is 15-25min.Such temperature and time, can guarantee fully to retain effective ingredient, is beneficial to curative effect.
Three of object of the present invention, is to provide the application of a kind of above-mentioned composition in the leukemic medicine of preparation treatment.
The capsule that compositions of the present invention is made or pill, 1 month be preferably a course for the treatment of, and 3 (early, middle and late) warm water delivery services of every natural gift, according to the different state of an illness, are taken 6-12 the course for the treatment of continuously.
The present invention is owing to having adopted above-mentioned technological means, thereby the beneficial effect producing is, this compositions and preparation thereof by the kidney invigorating hemopoietic, strong the spleen governs the blood, hold back liver hemostasis, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral, clearing away heat and cooling blood, hard masses softening and resolving, detoxicating, killing bacteria, detumescence blowdown, block removing hemopoietic and the softening approach that dwindles or eliminates liver spleen and lymphadenectasis is treated leukemia; Determined curative effect, various raw materials are all common Chinese medicine, safe and effective.And treatment is simple, safety, light no pain, expense is low, and curative effect is good again soon, stable lasting.To leukaemia's growth, expansion, and the caused anemia of leukemia, hemorrhage, infectious fever regulating liver-QI, spleen, lymphadenectasis, the symptom of skeleton pain can be controlled or eliminate; Can also regulate, stabilized leukocyte height and erythrocyte, hemoglobin, thrombocytopenia, make it to tend to normal recovery, or rehabilitation is normal.Leukemia early, mid-term patient, take medicine about 10 days, hemogram and disease all can be improved, and within 1-3 month, control the state of an illness, about half a year to 1 year, cure, drug withdrawal is not recurred.Patients with terminal, also can improve and stable hemogram, alleviates or eliminates complication, solves misery, improves the quality of living, and delays life.
The specific embodiment
Below by specific embodiment, the present invention is described in further detail.
Embodiment 1
Treat a leukemic Chinese medicine composition, by the raw material of following weight portion, formed:
15 parts of Herba Hedyotidis Diffusaes, 15 parts of Indigo Naturaliss, 15 parts, Radix Rehmanniae Preparata, 15 parts of Herba Ecliptaes, 10 parts of Rhizoma Drynariae, 5 parts of Fructus Corni, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Schisandrae Chinensis, 10 parts of Radix Ginsengs, 10 parts of the Radixs Astragali, 10 parts of Radix Angelicae Sinensis, 15 parts, Colla Corii Asini, 5 parts of Radix Et Rhizoma Rhei, 5 parts of Radix Notoginseng, 5 parts of Rhizoma Curcumae, 5 parts of Pheretimas, 5 parts of Cortex Moutans, 5 parts of Radix Bupleuri, 10 parts of Carapax Trionycis, 10 parts of Concha Ostreaes.
Above-mentioned raw materials is toasted to 25min at 220 ℃, and pulverizer breaks into powder, crosses 80 mesh sieves, removes after residue on sieve, obtains medicated powder, take Mel or fecula to be mixed into powder mud as binding agent and medicated powder, makes pill.
Embodiment 2
Treat a leukemic Chinese medicine composition, by the raw material of following weight portion, formed:
20 parts of Herba Hedyotidis Diffusaes, 20 parts of Indigo Naturaliss, 20 parts, Radix Rehmanniae Preparata, 20 parts of Herba Ecliptaes, 15 parts of Rhizoma Drynariae, 10 parts of Fructus Corni, 10 parts of Rhizoma Atractylodis, 10 parts of Fructus Schisandrae Chinensis, 15 parts of Radix Ginsengs, 15 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts, Colla Corii Asini, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Notoginseng, 10 parts of Rhizoma Curcumae, 10 parts of Pheretimas, 10 parts of Cortex Moutans, 10 parts of Radix Bupleuri, 15 parts of Carapax Trionycis, 15 parts of Concha Ostreaes.
Above-mentioned raw materials is toasted to 20min at 230 ℃, and pulverizer breaks into powder, crosses 80 mesh sieves, removes residue on sieve, obtains medicated powder, and medicated powder is incapsulated in shell, obtains.
Embodiment 3
Treat a leukemic Chinese medicine composition, by the raw material of following weight portion, formed:
25 parts of Herba Hedyotidis Diffusaes, 25 parts of Indigo Naturaliss, 25 parts, Radix Rehmanniae Preparata, 25 parts of Herba Ecliptaes, 20 parts of Rhizoma Drynariae, 15 parts of Fructus Corni, 15 parts of Rhizoma Atractylodis, 15 parts of Fructus Schisandrae Chinensis, 20 parts of Radix Ginsengs, 20 parts of the Radixs Astragali, 20 parts of Radix Angelicae Sinensis, 25 parts, Colla Corii Asini, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Notoginseng, 15 parts of Rhizoma Curcumae, 15 parts of Pheretimas, 15 parts of Cortex Moutans, 15 parts of Radix Bupleuri, 20 parts of Carapax Trionycis, 20 parts of Concha Ostreaes.
Above-mentioned raw materials is toasted to 15min at 230 ℃, and pulverizer breaks into powder, crosses 80 mesh sieves, removes residue on sieve, obtains medicated powder, and medicated powder is incapsulated in shell, obtains.
Embodiment 4
Treat a leukemic Chinese medicine composition, by the raw material of following weight portion, formed:
18 parts of Herba Hedyotidis Diffusaes, 21 parts of Indigo Naturaliss, 23 parts, Radix Rehmanniae Preparata, 25 parts of Herba Ecliptaes, 12 parts of Rhizoma Drynariae, 12 parts of Fructus Corni, 8 parts of Rhizoma Atractylodis, 6 parts of Fructus Schisandrae Chinensis, 16 parts of Radix Ginsengs, 17 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 19 parts, Colla Corii Asini, 14 parts of Radix Et Rhizoma Rhei, 7 parts of Radix Notoginseng, 9 parts of Rhizoma Curcumae, 11 parts of Pheretimas, 5 parts of Cortex Moutans, 15 parts of Radix Bupleuri, 12 parts of Carapax Trionycis, 17 parts of Concha Ostreaes.
Above-mentioned raw materials is toasted to 15min at 240 ℃, and pulverizer breaks into powder, crosses 80 mesh sieves, removes after residue on sieve, obtains medicated powder, take Mel or fecula to be mixed into powder mud as binding agent and medicated powder, makes pill.
Embodiment 5
The present embodiment has been selected several typical cases:
Case 1: thank certain, man 36 years old, in May, 2006 cases with leukemia, lymph enlargement pain.More than the doctor trained in Western medicine chemotherapy moon, do not control the state of an illness, leukocyte is 18 * 10
9/ L, erythrocyte are 2.7 * 10
12/ L, hemoglobin 68g/L, platelet are 62 * 10
9/ L.The traditional Chinese medical science is examined: Artemusia lactiflora Wall. is yellow, thready and rapid pulse, 39 ℃ of night sweat, thirsty, cough, fever heavy, left shoulder left chest pain at night, the red swollen bag of the left corners of the mouth, right shoulder cervical region 2 * 2 ㎝ lymph enlargements pains.Take the pill 15 days that the compositions of embodiment 1 makes, patient's night sweat, thirsty, cough, fever, shoulder chest pain, the swollen bag of the corners of the mouth, all diseases of lymph enlargement pain are all eliminated.Take pill that the compositions of embodiment 1 makes after 1 month, leukocyte is 12 * 10
9/ L, erythrocyte are 3 * 10
12/ L, hemoglobin 92g/L, platelet are 80 * 10
9/ L; Continue to take medicine after 3 months, leukocyte is 8 * 10
9/ L, erythrocyte are 3.6 * 10
12/ L, hemoglobin 110g/L, platelet are 132 * 10
9/ L; Continue to take medicine after 6 months, drug withdrawal disease is without recurrence, and all are normally stable.
Case 2: Wu, man, 60 years old, in JIUYUE, 2013 cases with leukemia, hepatosplenomegaly tenderness, leukocyte is 8 * 10
9/ L, erythrocyte are 1.9 * 10
12/ L, hemoglobin 80g/L, platelet are 48 * 10
9/ L.The traditional Chinese medical science is examined: body of the tongue is deep red, and tongue is thick in vain, and large pulse is soft, left arteries and veins is strong, and abdominal distention is heavy night, tastelessness, and abdominal distention after meal, weak.This case is taken the capsule 7 days that the compositions of embodiment 2 makes, and abdominal distention, weak, tastelessness symptom are improved, and appetite increases, in high spirits; Leukocyte is 8 * 10
9/ L, erythrocyte are 2.1 * 10
12/ L, hemoglobin 82g/L, platelet are 65 * 10
9/ L; Continue to take this capsule 1 month, weak, tastelessness is eliminated, and abdominal distention subtracts greatly, hepatic region, the deliquescing of speeding of abdominal swelling hard pine.Continue to take this capsule after 2 months, abdominal distention is not obvious, and liver is the spleen-distension, and large contraction diminishes, and leukocyte is 6 * 10
9/ L, erythrocyte are 2.9 * 10
12/ L, hemoglobin 90g/L, platelet are 85 * 10
9/ L.Continue to take this capsule after 3 months, hepatosplenomegaly dwindles 2/3rds, and leukocyte is 5 * 10
9/ L, erythrocyte are 3.5 * 10
12/ L, hemoglobin 109g/L, platelet are 100 * 10
9/ L, body is strong as usual.
Case 3, pays certain, female, and 28 years old, in February, 2012, suffer from acute thrombus type leukemia, menstruation is bled incessantly, and low grade fever does not move back; Leukocyte is 1.9 * 10
9/ L, erythrocyte are 1.7 * 10
12/ L, hemoglobin 65g/L, platelet are 7 * 10
9/ L.You Di district hospital racing provincial capital Affiliated Hospital of university rescues, the transfusion hemostasis of having an injection, and patient suffers a shock and does not wake up, and then retracts house and cremates.Ask this doctor to look at, faint pulse has jumping, at once acupuncture needle prick in servant, connected valleys two caves, after a few minutes, patient's eye movement is begun to open, and suddenly with hot ginger decoction, slowly fills with down, patient revives, but the lower part of the body is still bled and do not stopped.This case is taken capsule that the compositions of embodiment 3 makes after half a day, and blood does not only flow, and within 3 days, burns and moves back afterwards, from the vertical step of can taking food; Take medicine after 1 month, can take care of oneself, leukocyte is 3 * 10
9/ L, erythrocyte are 1.9 * 10
12/ L, hemoglobin 80g/L, platelet are 30 * 10
9/ L.Though patient comes back to life, because of former, bleed too much eventually, consume greatly vigour, life delays more than 4 months.
Case 4, Chen, man, 17 years old, in November, 2013, cases with leukemia, fever 39C, unbearably, leukocyte is 0.9 * 10 in toothache
9/ L, erythrocyte are 1.9 * 10
12/ L, hemoglobin 60g/L, platelet are 9 * 10
9/ L.The doctor trained in Western medicine chemotherapy several months, toothache hyperpyrexia is more than, and hemogram, without liter, sustains life by blood transfusion entirely.This case is taken the pill 6 days that the compositions of embodiment 4 makes, and toothache removes, and within 10 days, burns to move back as usually, and after 1 month, leukocyte is 2 * 10
9/ L, erythrocyte are 1.9 * 10
12/ L, hemoglobin 70g/L, platelet are 40 * 10
9/ L, effect is remarkable.
Embodiment 6
Compliance test result test
1. case selection:
Choose 200 examples and come from traditional Chinese medical science difficult disease subject study base, Station City, Zhumadian City, wherein, 160 examples are diagnosed as leukemia people in late period; 40 examples are diagnosed as early, mid-term leukemia people, be divided at random four groups, and every group all contain 40 example leukemia people in late period and 10 examples early, mid-term leukemia people;
2. test method:
Take respectively the medicine that the embodiment of the present invention 1,2,3,4 provides to four groups of patients, difference called after " 1 group of embodiment ", " 2 groups of embodiment ", " 3 groups of embodiment ", " 4 groups of embodiment ", every day early, middle and late servicing once, be to take every day three times, 30 days courses for the treatment of, according to state of an illness weight, treat continuously 1-12 the course for the treatment of;
3. curative effect judging standard:
Effective: because of unfavorable symptoms such as the caused anemia of leukemia, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pains, to alleviate or partial symptoms disappears; Can make leukocyte, erythrocyte, hemoglobin, platelet trend normally, or it is normal to reach recovery.
Cure: eliminate because of unfavorable symptoms such as the caused anemia of leukemia, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pains; Recover leukocyte, erythrocyte, hemoglobin, hematoblastic normal data, drug withdrawal is not recurred.
4. result of the test:
Wherein, the patient of early stage mild symptoms takes medicine 7 days, and severe one 1-2 month, a severe patient 3-6 month unfavorable symptom alleviated or partial symptoms disappearance or healing completely; Leukocyte, erythrocyte, hemoglobin, platelet partial data trend is normal recovers, or up to standard, or all data all recover up to standard, and after healing person's drug withdrawal, symptom is without recurrence completely, and leukocyte, erythrocyte, hemoglobin, platelet count are according to stably reaching standard.Its concrete statistical data is as shown in table 1:
The effect test result of the medicine that table 1 embodiment of the present invention 1-4 provides
| ? | 1 group of embodiment | 2 groups of embodiment | 3 groups of embodiment | 4 groups of embodiment |
| Effective number of cases (late period) | 35 | 37 | 36 | 35 |
| Effective number of cases (early, mid-term) | 10 | 10 | 10 | 10 |
| Total effective rate | 90% | 94% | 92% | 90% |
| Cure number of cases (early, mid-term) | 6 | 7 | 5 | 6 |
| Early, mid-term cure rate | 60% | 70% | 50% | 60% |
From table 1 and embodiment 5, can find out, its treatment of oral traditional Chinese medicine composition provided by the invention is simple, safety, easily no pain, expense are low, and curative effect is good again soon, stable lasting.To leukemia early, mid-term patient, take medicine about 10 days, hemogram and disease all can be improved, and within 1-3 month, control the state of an illness, about half a year to 1 year, cure, drug withdrawal is not recurred.To patients with terminal, also can improve and stable hemogram, alleviate or eliminate complication, solve misery, improve the quality of living, delay life.There is significant progress and practical value.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the leukemic Chinese medicine composition for the treatment of, is characterized in that, the raw material of following weight portion, consists of:
Herba Hedyotidis Diffusae 15-25 part, Indigo Naturalis 15-25 part, Radix Rehmanniae Preparata 15-25 part, Herba Ecliptae 15-25 part, Rhizoma Drynariae 10-20 part, Fructus Corni 5-15 part, Rhizoma Atractylodis 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Radix Ginseng 10-20 part, Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Colla Corii Asini 15-25 part, Radix Et Rhizoma Rhei 5-15 part, Radix Notoginseng 5-15 part, Rhizoma Curcumae 5-15 part, Pheretima 5-15 part, Cortex Moutan 5-15 part, Radix Bupleuri 5-15 part, Carapax Trionycis 10-20 part, Concha Ostreae 10-20 part.
2. the leukemic Chinese medicine composition for the treatment of according to claim 1, is characterized in that, the raw material of following weight portion, consists of:
20 parts of Herba Hedyotidis Diffusaes, 20 parts of Indigo Naturaliss, 20 parts, Radix Rehmanniae Preparata, 20 parts of Herba Ecliptaes, 15 parts of Rhizoma Drynariae, 10 parts of Fructus Corni, 10 parts of Rhizoma Atractylodis, 10 parts of Fructus Schisandrae Chinensis, 15 parts of Radix Ginsengs, 15 parts of the Radixs Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts, Colla Corii Asini, 10 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Notoginseng, 10 parts of Rhizoma Curcumae, 10 parts of Pheretimas, 10 parts of Cortex Moutans, 10 parts of Radix Bupleuri, 15 parts of Carapax Trionycis, 15 parts of Concha Ostreaes.
3. the acceptable preparation clinically that adopts the compositions of claim 1 or 2 to make.
4. preparation according to claim 3, is characterized in that: described preparation is capsule.
5. the preparation method of capsule claimed in claim 4, is characterized in that: by after raw material baking, pulverize, cross 80 mesh sieves, obtain medicated powder, described medicated powder is incapsulated in shell, obtain.
6. the preparation method of capsule claimed in claim 5, is characterized in that, baking temperature is 220-240 ℃, and baking time is 15-25min.
7. preparation according to claim 3, is characterized in that: described preparation is pill.
8. the preparation method of pill claimed in claim 7, is characterized in that: by after raw material baking, pulverize, cross 80 mesh sieves, obtain medicated powder, add binding agent mix homogeneously in described medicated powder, be then pressed into pill, obtain.
9. the preparation method of pill claimed in claim 8, is characterized in that, baking temperature is 220-240 ℃, and baking time is 15-25min.
10. claim 1 or 2 the compositions application in the leukemic medicine of preparation treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410056222.5A CN103736038B (en) | 2014-02-19 | 2014-02-19 | Treat leukemic Chinese medicine composition, its preparation and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410056222.5A CN103736038B (en) | 2014-02-19 | 2014-02-19 | Treat leukemic Chinese medicine composition, its preparation and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103736038A true CN103736038A (en) | 2014-04-23 |
| CN103736038B CN103736038B (en) | 2016-01-20 |
Family
ID=50493154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410056222.5A Expired - Fee Related CN103736038B (en) | 2014-02-19 | 2014-02-19 | Treat leukemic Chinese medicine composition, its preparation and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103736038B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1390588A (en) * | 2002-08-06 | 2003-01-15 | 王凯 | Composite medicine for treating leukemia |
| CN1879841A (en) * | 2006-05-17 | 2006-12-20 | 郭富红 | A Chinese medicine for treating leukemia |
-
2014
- 2014-02-19 CN CN201410056222.5A patent/CN103736038B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1390588A (en) * | 2002-08-06 | 2003-01-15 | 王凯 | Composite medicine for treating leukemia |
| CN1879841A (en) * | 2006-05-17 | 2006-12-20 | 郭富红 | A Chinese medicine for treating leukemia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103736038B (en) | 2016-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107303384B (en) | A Chinese medicinal composition for treating various symptoms, and its derivatives and products | |
| CN102631649B (en) | Method for preparing traditional Chinese medicine (TCM) for treating kidney-Yang deficiency type colitis | |
| CN102657835B (en) | Composition and medical liquor for treatment of high blood pressure/rheumatoid arthritis and preparation method and application of composition and medical liquor | |
| CN103127472B (en) | Traditional Chinese medicine compound for refractory insomnia | |
| CN104888131A (en) | Traditional Chinese medicine composition for treatment of insomnia | |
| CN1320914C (en) | Menstruation regulating powder | |
| CN109939191A (en) | Chinese medicine composition, preparation method and the application of bone marrow suppression after a kind of antagonism chemotherapy of tumors | |
| CN104398830A (en) | Traditional Chinese medicine preparation for treating iron-deficiency anemia and preparation method of traditional Chinese medicine preparation | |
| CN104042981A (en) | Medicament for treating postnatal constipation and preparation method thereof | |
| CN108014303A (en) | A kind of Chinese medicine preparation for treating Ru Repair-in and preparation method thereof | |
| CN103736038B (en) | Treat leukemic Chinese medicine composition, its preparation and application | |
| CN104258299A (en) | Traditional Chinese medicine for treating mumps | |
| CN104940752A (en) | Chinese medicine preparation for treating vulva ulcer and preparing method thereof | |
| CN104587443A (en) | Traditional Chinese medicine preparation for primary antiphospholipid syndrome and preparation method thereof | |
| CN104721802A (en) | TCM (traditional Chinese medicine) preparation for treating constrictive pericarditis and preparing method thereof | |
| CN104688882A (en) | TCM (Traditional Chinese Medicine) composition for treating fever in children | |
| CN103142854B (en) | Chinese medicine composition for performing postoperation cooperative treatment on mammary intraepithelial neoplasia | |
| CN105287953A (en) | Preparation with uremia treating effect and preparation method | |
| CN113116987A (en) | A Chinese medicinal composition for treating tumor, and its preparation method | |
| CN113893320A (en) | Traditional Chinese medicine for treating hypertension and complications | |
| CN105327024A (en) | Traditional Chinese medicine preparation for treating rheumatoid arthritis | |
| CN104888091A (en) | Traditional Chinese medicine composition for treating intestinal form of acute radiation sickness and preparation method of traditional Chinese medicine composition | |
| CN105362610A (en) | Traditional Chinese medicine composition for treating coronary artery diseases | |
| CN104162096A (en) | Traditional Chinese medicine for treating melanosis | |
| CN103386083B (en) | A kind of pharmaceutical composition for the treatment of type ii diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160120 Termination date: 20220219 |