CN103142854B - Chinese medicine composition for performing postoperation cooperative treatment on mammary intraepithelial neoplasia - Google Patents
Chinese medicine composition for performing postoperation cooperative treatment on mammary intraepithelial neoplasia Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition for performing postoperation cooperative treatment on mammary intraepithelial neoplasia. The Chinese medicine composition is prepared from Chinese angelica, white paeony roots, radix bupleuri, poria cocos, fried bighead atractylodes rhizome, green tangerine peels, dried tangerine peels, nutgrass galingale rhizome, szechwan Chinaberry fruits, pinellia ternate, rhizoma arisaematis, semen brassicae, snake gourd fruits, tangerine seeds, figwort roots, raw oyster shells, big fritillaria, spina gleditsiae, selfheal, weeping forsythiae capsule, Indian iphigenia bulbs, seaweed, sea-tent, rhizoma curculiginis and herba epimedii in a certain weight proportion, and has functions of promoting blood circulation and arresting pain, tretching liver to smooth qi, softening hard lump and dissipating stagnation and tuning up qi blood; and after the Chinese medicine composition can effectively treat the mammary intraepithelial neoplasia in a cooperative mode, common epithelium hyperplasia of a mammary duct is delayed and changed into atypical hyperplasia, preinvasive carcinoma and infiltrating carcinoma.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition that becomes postoperative partner treatment for tumor in breast epithelium.
Background technology
Breast duct intraepithelial neoplasia (DIN) is the common type of breast lesion, be Precancerous Lesions of Breast, proliferative lesion has referred to be derived from mammary gland last conduit lobule unit (TDLU) at end and to be confined to a group of breast duct lobule system and in cellular morphology and organizational structure, has been the pathological changes of hypertrophy in various degree in breast duct.Traditionally, in breast duct, proliferative lesion is divided into 3 classes: common conduit epithelial proliferation (UDH), ductal epithelium atypical hyperplasia (ADH) and ductal carcinoma in situ(DCIS) (DCIS).Its biological behaviour is very different, and clinical manifestation, histopathology form, Biomarkers and progress are all different, also different from infiltrating carcinoma, and the danger that cancer occurs in prompting has rising in various degree.They are emphasis, difficult point and the focus of domestic and international pathology, surgery and motherland's traditional medicine research always.Surgery is generally treated in excision mode, but easily recurs and change to higher level.Primary disease, in tcm clinical practice, belongs to the categories such as " breast carcinoma ", " mammary calculus carbuncle " more.Chinese medicine thinks that primary disease is due to disorder of emotion, depression of liver-QI or because of Chong and Ren channel disorder, QI-blood circulation is not smooth, and qi stagnation hemagglutination, meridians block, and tie stagnant due to the Ruzhong.Chinese medicine has endocrine regulation, compensate qi and blood, improves qi-blood circulating, the special efficacy of hard masses softening and resolving, can early prevention breast carcinoma, make breast duct intraepithelial neoplasia patient obtain in early days suitable treatment, prevented again treatment, can avoid the operation of disabling property, obtain good quality of life and long-term surviving, and effect is lasting, treating both the principal and secondary aspects of a disease, has no side effect, and efficacy consolidation, is difficult for recurrence.Physically and mentally healthy for ensureing women, alleviate China's basic medical burden, alleviate breast carcinoma and will produce significant impact to the inhibition of economic development, also will be subject to more and more doctor, patient and economic society policymaker's favor.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition becomes and has the effects such as blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, hard masses softening and resolving, compensate qi and blood for tumor in the postoperative breast epithelium of partner treatment.
The present invention selects Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Poria, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Toosendan, the Rhizoma Pinelliae, Rhizoma Arisaematis, Semen Sinapis Albae, Fructus Trichosanthis, Semen Citri Reticulatae, Radix Scrophulariae, Concha Ostreae, Bulbus Fritillariae Thunbergii, Spina Gleditsiae, Spica Prunellae, Fructus Forsythiae, Pseudobulbus Cremastrae Seu Pleiones, Sargassum, Thallus Laminariae (Thallus Eckloniae), Rhizoma Curculiginis, Herba Epimedii to combine, make each efficacy of drugs produce synergism these drug regimens, make it to there is blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, hard masses softening and resolving, the effect of compensate qi and blood, thus can effectively coordinate tumor in breast epithelium to become post-operative recovery.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.
The Radix Paeoniae Alba: be the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor are bitter, sour, cool.Return liver, spleen channel.Effect: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.
Radix Bupleuri: be dry root or the herb of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor are slightly cold, bitter, pungent.Return liver, lung, spleen channel.Effect: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor are bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis.
Pericarpium Citri Reticulatae Viride: be the dry young fruit of rutaceae orange Citrus reticulata Blanco and variety thereof or the peel of immature fruit.Nature and flavor are bitter, pungent, temperature.Enter liver, gallbladder, stomach warp.Effect: soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.
Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor temperature, pungent, bitter.Enter spleen, stomach, lung meridian.Effect: regulate the flow of vital energy in tune, spleen invigorating, drying dampness to eliminate phlegm.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Pungent, the micro-bitter, sweet, flat of nature and flavor.Enter liver, tri-jiao channel.Effect: the resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Rhizoma Cyperi volatile oil has slight estrogenic activity.
Fructus Toosendan: be the dry mature fruit of Meliaceae plant Fructus Toosendan Melia toosendan Sieb. et Zucc..Nature and flavor are bitter, cold; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Effect: soothing liver-QI circulation of qi promoting, pain relieving.
The Rhizoma Pinelliae: be Araeceae herbaceos perennial.Nature and flavor are pungent, and temperature is poisonous.Enter spleen, stomach warp.Effect: removing dampness spleen invigorating, antidiarrheal helps digestion.There is anticancer effect.
Rhizoma Arisaematis: be the dry tuber of aroid Rhizoma Arisaematis Arisaema erubescens (Wall.) Schott, Arisaema heterophyllum B1. Arisaema heterophyllum Bl. or arisaema amurense Maxim Arisaema amurense Maxim..Nature and flavor are bitter, pungent, temperature; Poisonous.Return lung, liver, spleen channel.Effect: drying dampness to eliminate phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating.There is antitumor action.
Semen Sinapis Albae: be the mature seed of crucifer Caulis et Folium Sinapis albee.Nature and flavor are pungent, heat.Enter meridian of Hand-TAI YIN.Function: warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.
Fructus Trichosanthis: be the seed of cucurbitaceous plant Fructus Trichosanthis and Chinese Fructus Trichosanthis.Nature and flavor are sweet, bitter, cold.Enter lung, stomach, large intestine channel.Effect: moistening the lung and resolving phlegm, eliminating stagnation intestine moistening.
Semen Citri Reticulatae: be the dry mature seed of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor are bitter, flat.Return liver, kidney channel.Effect: regulate the flow of vital energy, pain relieving.< < Bencao Beiyao > >: row irritability, Sweeling-eliminating medicine powder poison.
Radix Scrophulariae: be the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor are sweet, bitter, salty, are slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.
Concha Ostreae: be the shell of the long Concha Ostreae Ostrea of Ostreidae animal gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Crosse or Crassostrea rivularis Ostrea rivularis Gould.Nature and flavor are salty, are slightly cold.Return liver, gallbladder, kidney channel.Effect: suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.
Bulbus Fritillariae Thunbergii: be the underground bulb of Liliaceae herbaceos perennial Bulbus Fritillariae Thunbergii.Nature and flavor are bitter, cold.Enter cardiopulmonary warp.Function: removing heat-phlegm, powder detoxifcation.
Spina Gleditsiae: be the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor are pungent, temperature.Return lung, Liver Channel.Effect: detumescence and apocenosis, promoting blood circulation by removing wind.There is antitumaous effect.
Spica Prunellae: be the dry fruit ear of labiate Spica Prunellae Prunella vulgaris L..Nature and flavor bitter, acrid, cold.Enter liver, gallbladder meridian.Effect: the improving eyesight of relieving inflammation or internal heat, mass dissipating and swelling eliminating.
Fructus Forsythiae: be the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Nature and flavor are bitter, are slightly cold.Return lung, the heart, gallbladder meridian.Effect: heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.
Pseudobulbus Cremastrae Seu Pleiones: be the dry pseudobulb of orchid Du Juan orchid, pleione bulbocodioides Rolfe or Pleione yunnanensis P. yunnansis Rolfe.Nature and flavor are sweet, micro-pungent, cool.Return liver, spleen channel.Effect: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
Sargassum: be Sargassaceae plant Sargassum Sargassum pallidum(Turn.) the dry frond of C. Ag. or Sargassum fusiforme (Harv.) Setch Sargassum fusiforme (Harv.) Setch..Nature and flavor are bitter, salty, cold.Return lung, spleen, kidney, liver stomach warp.Effect: hard masses softening and resolving; Heat clearing away expectorant; Diuretic detumescent.There is antitumor action.
Thallus Laminariae (Thallus Eckloniae): be the dry thallus of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) Laminaria japonica Aresch. or Alariaceae plant Thallus Laminariae (Thallus Eckloniae) Ecklonia kurome Okam..Nature and flavor are salty, cold; Nontoxic.Return liver, stomach, kidney channel.Effect: eliminating phlegm and softening indurated mass; Diuretic detumescent.
Rhizoma Curculiginis: be the dry rhizome of amrallid Rhizoma Curculiginis Curculigo orchioides Gaertn..Nature and flavor are pungent, and temperature is poisonous.Enter kidney, Liver Channel.Effect: reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening, promoting the circulation of blood detumescence.
Herba Epimedii: be the dried leaves of Berberidaceae plant Herba Epimedii (Epimedium brevicornum Maxim.), arrow leaf Herba Epimedii (Epimedium sagittatumMaxim.), pubescence Herba Epimedii (Epimedium pubescens Maxim.) or Herba Epimedii (Epimedium koreanum Nakai).Nature and flavor acrid, sweet, warm.Return liver, kidney channel.Effect: kidney invigorating and YANG supporting; Expelling wind and removing dampness; Strengthening the tendons and bones.
Medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope: Radix Angelicae Sinensis 15-25 part, Radix Paeoniae Alba 25-35 part, Radix Bupleuri 10-20 part, Poria 15-25 part, Rhizoma Atractylodis Macrocephalae (parched) 10-20 part, Pericarpium Citri Reticulatae Viride 10-20 part, Pericarpium Citri Reticulatae 7-17 part, Rhizoma Cyperi 10-20 part, Fructus Toosendan 10-20 part, Rhizoma Pinelliae 7-17 part, Rhizoma Arisaematis 5-15 part, Semen Sinapis Albae 5-15 part, Fructus Trichosanthis 15-25 part, Semen Citri Reticulatae 10-20 part, Radix Scrophulariae 10-20 part, Concha Ostreae 25-35 part, Bulbus Fritillariae Thunbergii 10-20 part, Spina Gleditsiae 10-20 part, Spica Prunellae 10-20 part, Fructus Forsythiae 7-17 part, Pseudobulbus Cremastrae Seu Pleiones 5-15 part, Sargassum 10-20 part, Thallus Laminariae (Thallus Eckloniae) 7-17 part, Rhizoma Curculiginis 10-20 part, Herba Epimedii 15-25 part.
Wherein be preferably: 20 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 15 parts of Radix Bupleuri, 20 parts, Poria, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 15 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Pericarpium Citri Reticulataes, 15 parts of Rhizoma Cyperis, 15 parts of Fructus Toosendans, 12 parts of the Rhizoma Pinelliaes, 10 parts of Rhizoma Arisaematiss, 10 parts of Semen Sinapis Albaes, 20 parts of Fructus Trichosanthis, 15 parts of Semen Citri Reticulataes, 15 parts of Radix Scrophulariaes, 30 parts of Concha Ostreae, 15 parts of Bulbus Fritillariae Thunbergii, 15 parts of Spina Gleditsiaes, 15 parts of Spica Prunellaes, 12 parts of Fructus Forsythiaes, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Sargassums, 12 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of Rhizoma Curculiginises, 20 parts of Herba Epimedii.
Medicine of the present invention can adopt the conventional preparation technology of Chinese medicine preparation, can be made into said dosage form on any pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.For example these crude drug grind into fine powder mix homogeneously can be made to powder takes after mixing it with water; Can use decocting, obtain after filtration filtrate, add antiseptic to make oral liquid; Also can directly take decoction if desired.
Chinese medicine composition of the present invention becomes the rear partner treatment of operation for tumor in breast epithelium just, reverses the common epithelial proliferation of breast duct, delays and reverses and develop into dysplasia, cancer in situ, infiltrating carcinoma, and there is blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, hard masses softening and resolving, the effects such as compensate qi and blood.
The specific embodiment
Embodiment mono-, 15 parts of Radix Angelicae Sinensis, 25 parts of the Radix Paeoniae Albas, 10 parts of Radix Bupleuri, 15 parts, Poria, 10 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 10 parts, Pericarpium Citri Reticulatae Viride, 7 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Cyperis, 10 parts of Fructus Toosendans, 7 parts of the Rhizoma Pinelliaes, 5 parts of Rhizoma Arisaematiss, 5 parts of Semen Sinapis Albaes, 15 parts of Fructus Trichosanthis, 10 parts of Semen Citri Reticulataes, 10 parts of Radix Scrophulariaes, 25 parts of Concha Ostreae, 10 parts of Bulbus Fritillariae Thunbergii, 10 parts of Spina Gleditsiaes, 10 parts of Spica Prunellaes, 7 parts of Fructus Forsythiaes, 5 parts of Pseudobulbus Cremastrae Seu Pleioness, 10 parts of Sargassums, 7 parts of Thallus Laminariae (Thallus Eckloniae)s, 10 parts of Rhizoma Curculiginises, 15 parts of Herba Epimedii.
Embodiment bis-, 20 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 15 parts of Radix Bupleuri, 20 parts, Poria, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 15 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Pericarpium Citri Reticulataes, 15 parts of Rhizoma Cyperis, 15 parts of Fructus Toosendans, 12 parts of the Rhizoma Pinelliaes, 10 parts of Rhizoma Arisaematiss, 10 parts of Semen Sinapis Albaes, 20 parts of Fructus Trichosanthis, 15 parts of Semen Citri Reticulataes, 15 parts of Radix Scrophulariaes, 30 parts of Concha Ostreae, 15 parts of Bulbus Fritillariae Thunbergii, 15 parts of Spina Gleditsiaes, 15 parts of Spica Prunellaes, 12 parts of Fructus Forsythiaes, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Sargassums, 12 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of Rhizoma Curculiginises, 20 parts of Herba Epimedii.
Embodiment tri-, 25 parts of Radix Angelicae Sinensis, 35 parts of the Radix Paeoniae Albas, 20 parts of Radix Bupleuri, 25 parts, Poria, 20 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 20 parts, Pericarpium Citri Reticulatae Viride, 17 parts of Pericarpium Citri Reticulataes, 20 parts of Rhizoma Cyperis, 20 parts of Fructus Toosendans, 17 parts of the Rhizoma Pinelliaes, 15 parts of Rhizoma Arisaematiss, 15 parts of Semen Sinapis Albaes, 25 parts of Fructus Trichosanthis, 20 parts of Semen Citri Reticulataes, 20 parts of Radix Scrophulariaes, 35 parts of Concha Ostreae, 20 parts of Bulbus Fritillariae Thunbergii, 20 parts of Spina Gleditsiaes, Spica Prunellae 10-20 part, 17 parts of Fructus Forsythiaes, 15 parts of Pseudobulbus Cremastrae Seu Pleioness, 20 parts of Sargassums, 17 parts of Thallus Laminariae (Thallus Eckloniae)s, 20 parts of Rhizoma Curculiginises, 25 parts of Herba Epimedii.
Therapeutic Method of the present invention:
According to drug weight proportioning of the present invention, weighting raw materials (dose), decocting, filter and remove residue, every day three times, 30th is a course for the treatment of.
Model case:
Case one, Zhang, 29 years old, there is right one week of milk flow pus of breast, through cytodiagnosis, be breast ductal epithelium intraepithelial neoplasia, the excision of being in hospital.Postoperative patient is taken a course for the treatment of of Chinese medicine partner treatment of the present invention, and result of clinical detection breast duct epithelium is replied as simple columnar epithelium.
Case two, Chen, 35 years old age, right cyclomastopathy, in kitchen range lobule, whole last conduit and leaf inner catheter are low level intraepithelial neoplasia.This month, has just been finished resection operation.Postoperative patient is taken two courses for the treatment of of Chinese medicine partner treatment of the present invention, result of clinical detection breast duct epithelium part epithelium generation degenerative change.
Case three, poplar, 41 years old, left breast had lump, superficial, and cyclomastopathy merges kitchen range epithelium and is low level intraepithelial neoplasia.Before one week, finished resection operation.Postoperative patient is taken two courses for the treatment of of Chinese medicine partner treatment of the present invention, result of clinical detection breast duct epithelium degenerative atrophy.
Claims (2)
1. for tumor in breast epithelium, become the Chinese medicine composition of postoperative partner treatment, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Angelicae Sinensis 15-25 part, Radix Paeoniae Alba 25-35 part, Radix Bupleuri 10-20 part, Poria 15-25 part, Rhizoma Atractylodis Macrocephalae (parched) 10-20 part, Pericarpium Citri Reticulatae Viride 10-20 part, Pericarpium Citri Reticulatae 7-17 part, Rhizoma Cyperi 10-20 part, Fructus Toosendan 10-20 part, Rhizoma Pinelliae 7-17 part, Rhizoma Arisaematis 5-15 part, Semen Sinapis Albae 5-15 part, Fructus Trichosanthis 15-25 part, Semen Citri Reticulatae 10-20 part, Radix Scrophulariae 10-20 part, Concha Ostreae 25-35 part, Bulbus Fritillariae Thunbergii 10-20 part, Spina Gleditsiae 10-20 part, Spica Prunellae 10-20 part, Fructus Forsythiae 7-17 part, Pseudobulbus Cremastrae Seu Pleiones 5-15 part, Sargassum 10-20 part, Thallus Laminariae (Thallus Eckloniae) 7-17 part, Rhizoma Curculiginis 10-20 part, Herba Epimedii 15-25 part.
2. the Chinese medicine composition that becomes postoperative partner treatment for tumor in breast epithelium according to claim 1, it is characterized in that, ingredients by following weight portion: 20 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 15 parts of Radix Bupleuri, 20 parts, Poria, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 15 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Pericarpium Citri Reticulataes, 15 parts of Rhizoma Cyperis, 15 parts of Fructus Toosendans, 12 parts of the Rhizoma Pinelliaes, 10 parts of Rhizoma Arisaematiss, 10 parts of Semen Sinapis Albaes, 20 parts of Fructus Trichosanthis, 15 parts of Semen Citri Reticulataes, 15 parts of Radix Scrophulariaes, 30 parts of Concha Ostreae, 15 parts of Bulbus Fritillariae Thunbergii, 15 parts of Spina Gleditsiaes, 15 parts of Spica Prunellaes, 12 parts of Fructus Forsythiaes, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Sargassums, 12 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of Rhizoma Curculiginises, 20 parts of Herba Epimedii.
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