CN103736038B - Treat leukemic Chinese medicine composition, its preparation and application - Google Patents
Treat leukemic Chinese medicine composition, its preparation and application Download PDFInfo
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Abstract
The invention provides one and treat leukemic Chinese medicine composition, its preparation and application, compositions of the present invention consist of Herba Hedyotidis Diffusae, Indigo Naturalis, Radix Rehmanniae Preparata, Herba Ecliptae, Rhizoma Drynariae, Fructus Corni, Rhizoma Atractylodis, Fructus Schisandrae Chinensis, Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, Colla Corii Asini, Radix Et Rhizoma Rhei, Radix Notoginseng, Rhizoma Curcumae, Pheretima, Cortex Moutan, Radix Bupleuri, Carapax Trionycis, Concha Ostreae, and have employed suitable ratio; The curative effect of medication that above-mentioned composition is made is definite, and various raw material is all common Chinese medicine, safe and effective; Leukemia early, mid-term patient, take medicine about 10 days, hemogram and disease all can be improved, 1-3 month symptom management, and cure about half a year to 1 year, drug withdrawal is not recurred; Patients with terminal, also can improve and stable hemogram, alleviate or eliminate complication, solves painful, improves the quality of living, delay life.
Description
Technical field
The present invention relates to field of medicaments, treat leukemic Chinese medicine composition, its preparation and application in particular to one.
Background technology
Leukemia is the Clonal malignant disease of a class hematopoietic stem cell exception.Be divided into acute lymphoblastic leukemia, acute myelocytic leukemia clinically; Chronic myelocytic leukemia, chronic lymphocytic leukemia etc.
The leukemic cause of disease, Western medicine diagnose is viral factor, chemical factor, radiation factor and inherited genetic factors and cause.The traditional Chinese medical science think due to the absurd row of heat in blood forcing blood or deficiency of kidney-YIN or epidemic febrile disease enter in, pathogenic heat to cave in etc. because become.
The clinical visible anemia in various degree of leukemia, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pain, blood testing, granulocyte, lymphocyte, leukocyte or high or low; Erythrocyte, hemoglobin, platelet all decline and reduce.Face in card, have again hepatosplenomegaly type and the large-scale leukemia of the enlargement of lymph node.Its pathogenesis is asthenia of both the spleen and kidney, and stagnation of liver-QI network hinders, and virus enters blood, hemocyte is made a variation and breeds, infiltrate other histiocyte, destroy hemopoietic system, and infringement hemopoietic function, makes hemopoietic function go down; Unhygienic diet, dirty stifled marrow key, causes hematopoietic disorders, forms aplastic anemia leukemia.
At present, medical profession to leukemic treatment, doctor trained in Western medicine method for the treatment of: change Bone Marrow Treatment, chemotherapy, radiotherapy, targeted therapy, immunization therapy etc.Can have a curative effect, but it is difficult to change Bone Marrow Treatment distribution type, and involves great expense; And chemotherapeutic drug therapy is painful, have again many side effect, as killed and wounded, suppressing normal hematopoetic cells, suppress normal immunological function, immunity of organisms declines, and easily merges various infection; Injure gastrointestinal tract mucous, cause anorexia Nausea and vomiting, affect darling renal function, chemotherapeutics also can make the second Tumor incidence increase in addition.Moreover, more heavy dose of leukaemia that also can not kill completely in body, the root of residual leukaemia always palindromia.The Traditional Chinese Medicine rule for the treatment of: intend Chinese prescription and take orally, benefiting qi and nourishing blood, regulate negative and positive, clearing away heat and cooling blood, eliminating fire and detoxication, hemostasis etc.Though the recovery of normal hematopoiesis function and bone marrow can be protected, prevent chemotherapeutics from causing serious bone marrow transplantation, reduce blood transfusion, reduce hemorrhage; Promote the recovery of normal immunological function, reduce and infect complication, but curative effect is also undesirable, therapy of combining Chinese and Western medicine, curative effect is slightly good, still inconsiderable.
Summary of the invention
An object of the present invention, is to provide a kind of determined curative effect, safe and reliable Chinese medicine composition, to solve the above problems.
The technical scheme adopted is: one treats leukemic Chinese medicine composition, is made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 15-25 part, Indigo Naturalis 15-25 part, Radix Rehmanniae Preparata 15-25 part, Herba Ecliptae 15-25 part, Rhizoma Drynariae 10-20 part, Fructus Corni 5-15 part, Rhizoma Atractylodis 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Radix Ginseng 10-20 part, Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Colla Corii Asini 15-25 part, Radix Et Rhizoma Rhei 5-15 part, Radix Notoginseng 5-15 part, Rhizoma Curcumae 5-15 part, Pheretima 5-15 part, Cortex Moutan 5-15 part, Radix Bupleuri 5-15 part, Carapax Trionycis 10-20 part, Concha Ostreae 10-20 part.
In the present invention, Herba Hedyotidis Diffusae is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae (Hedyotisdiffusa), Indigo Naturalis (Indigonaturalis) is dicotyledon medicine acanthaceous vegetable acanthaceous indigo, dry pigment in dicotyledon medicine leguminous plant Folium et Caulis Indigoferae Tinctoriae, dicotyledon medicine cruciferae isatis, careless Folium Isatidis or polygonaceae plant polygonum tinctorium ait. leaf, these two kinds of raw materials in the composition act as detoxicating, killing bacteria, suppressing and eliminate leukaemia, is the monarch drug in this prescription;
When being classified as the root of Umbelliferae angelica herbaceous plant Radix Angelicae Sinensis (Angelicasinensis), Rhizoma Curcumae is Zingiberaceae curcuma Rhizoma Curcumae (Curcumazedoaria(Christm.) Rosc.) rhizome, Cortex Moutan is the root bark of Ranunculaceae Paeonia plant Paeonia suffruticosa (PaeoniasuffruticosaAndr.), Radix Bupleuri is the root of umbelliferae bupleurum (Bupleurumchinense), Carapax Trionycis is the carapace of Trionychidae animal Trionyx sinensis Wiegmann (TrionyxsinensisWiegmann), Concha Ostreae is Ostreidae (the true Concha Ostreae of Ostreidae) or Yan Ha section (Aviculidae pearl oyster) animal body, the effect of this several raw material is clearing away heat and cooling blood, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral, hard masses softening and resolving, auxiliary monarch drug is eliminating evil, for the ministerial drug in this prescription,
Radix Rehmanniae Preparata is the root of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmanniaglutinosa), Herba Ecliptae is the aerial parts of feverfew Eclipta prostrata (EcliptaprostrataL.), Rhizoma Drynariae is Davalliaceae (Davalliaceae) plant great Ye Rhizoma Drynariae, the rhizome of the plants such as Rhizoma Drynariae, Fructus Corni is the sarcocarp of Cornaceae plant Fructus Corni (Cornus.officinalis), Rhizoma Atractylodis are the rhizome of Compositae [WTBX plant Rhizoma Atractylodis (Atractylodeslancea), Fructus Schisandrae Chinensis is the fruit of Schisandraceae Plant Fructus Schisandrae Chinensis (Schisandrachinensis), Radix Ginseng is the root of Araliaceae Radix Ginseng (Panaxginseng), the Radix Astragali is the root of the leguminous plant Radix Astragali (Astragalusmembranaceus (Fisch.) Bunge.), Colla Corii Asini is the stabilized animal glue after donkey skin decocting and concentrating, Radix Notoginseng is the root of panax araliaceae plant (PanaxpseudoginsengWall.var.notoginseng (Burkill) HooetTseng), the effect of this several raw material is kidney and spleen invigorating, benefiting QI and nourishing blood, hold back liver hemostasis, strengthening the body resistance, increase the power that monarch drug is eliminating evil, for the adjuvant drug in this prescription,
Radix Et Rhizoma Rhei is the rhizome of polygonaceae plant Radix Et Rhizoma Rhei (RheumpalmatumL.), Pheretima is the entirety of Ju Yin section animal Pheretima aspergillum Pheretimaaspergilum (EPerrier), popular Pheretimatschiliensis PvulgarisChen, power simulation Pguillelmi (Michaelsen) or comb the region between the heart and the diaphragm hair earthworm PpectiniferaMichaelsen, the effect of these two kinds of raw materials is smoothening secretion, blowdown block removing, in order to hemopoietic, for making medicine in this prescription.
Present inventor uses Chinese medical theory, selects suitable raw material and ratio, obtains above-mentioned Chinese medicine composition.Mutually work in coordination with between these raw materials, by the kidney invigorating hemopoietic, strong the spleen governs the blood, hold back liver hemostasis, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral, clearing away heat and cooling blood, hard masses softening and resolving, detoxicating, killing bacteria, detumescence blowdown, block removing hemopoietic, and soften reduce or eliminate liver spleen and lymphadenectasis approach to treat leukemia; Determined curative effect, various raw material is all common Chinese medicine, safe and effective.To growth, the expansion of leukaemia, and anemia caused by leukemia, hemorrhage, infectious fever regulating liver-QI, spleen, lymphadenectasis, the symptom of skeleton pain can control or eliminate; Can also regulate, stabilized leukocyte height and erythrocyte, hemoglobin, thrombocytopenia, make it to tend to normal recovery, or rehabilitation is normal.Leukemia early, mid-term patient, take medicine about 10 days, hemogram and disease all can be improved, 1-3 month symptom management, and cure about half a year to 1 year, drug withdrawal is not recurred.Patients with terminal, also can improve and stable hemogram, alleviate or eliminate complication, solves painful, improves the quality of living, delay life.
As preferred technical scheme: one treats leukemic Chinese medicine composition, be made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 20 parts, Indigo Naturalis 20 parts, 20 parts, Radix Rehmanniae Preparata, Herba Ecliptae 20 parts, Rhizoma Drynariae 15 parts, Fructus Corni 10 parts, Rhizoma Atractylodis 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Ginseng 15 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, 20 parts, Colla Corii Asini, Radix Et Rhizoma Rhei 10 parts, Radix Notoginseng 10 parts, Rhizoma Curcumae 10 parts, Pheretima 10 parts, Cortex Moutan 10 parts, Radix Bupleuri 10 parts, Carapax Trionycis 15 parts, Concha Ostreae 15 parts.
Clinical trial proves, adopts such ratio, treats leukemic better effects if.
Object two of the present invention, is to provide the acceptable clinically preparation adopting above-mentioned compositions to make.
As preferred scheme: described preparation is capsule.Capsule taking convenience, easy to make.
The preparation method of above-mentioned capsule is: after being toasted by raw material, pulverize, cross 80 mesh sieves, obtain medicated powder, incapsulate in shell, to obtain final product described medicated powder.
As preferred technical scheme, in above-mentioned preparation method, baking temperature is 220-240 DEG C, and baking time is 15-25min.Such temperature and time, can ensure fully to retain effective ingredient, be beneficial to curative effect.
As preferred technical scheme: described preparation is pill.Pill preparation is simple, and preparation cost is low.
The preparation method of above-mentioned pill: after raw material is toasted, pulverize, cross 80 mesh sieves, obtain medicated powder, add binding agent mix homogeneously in described medicated powder, be then pressed into pill, to obtain final product.
As preferred technical scheme, prepare in the process of pill, baking temperature is 220-240 DEG C, and baking time is 15-25min.Such temperature and time, can ensure fully to retain effective ingredient, be beneficial to curative effect.
Object three of the present invention, is to provide the application of a kind of above-mentioned composition in the leukemic medicine of preparation treatment.
The capsule that compositions of the present invention is made or pill 1 month are preferably a course for the treatment of, and every natural gift 3 (early, middle and late) warm water delivery services, according to the different state of an illness, take 6-12 the course for the treatment of continuously.
The present invention is owing to have employed above-mentioned technological means, thus the beneficial effect produced is, this compositions and preparation thereof by the kidney invigorating hemopoietic, strong the spleen governs the blood, hold back liver hemostasis, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral, clearing away heat and cooling blood, hard masses softening and resolving, detoxicating, killing bacteria, detumescence blowdown, block removing hemopoietic and the softening approach reduced or eliminate liver spleen and lymphadenectasis and treat leukemia; Determined curative effect, various raw material is all common Chinese medicine, safe and effective.And treatment is simple, safety, easily no pain, expense is low, and curative effect is good again soon, stable lasting.To growth, the expansion of leukaemia, and anemia caused by leukemia, hemorrhage, infectious fever regulating liver-QI, spleen, lymphadenectasis, the symptom of skeleton pain can control or eliminate; Can also regulate, stabilized leukocyte height and erythrocyte, hemoglobin, thrombocytopenia, make it to tend to normal recovery, or rehabilitation is normal.Leukemia early, mid-term patient, take medicine about 10 days, hemogram and disease all can be improved, 1-3 month symptom management, and cure about half a year to 1 year, drug withdrawal is not recurred.Patients with terminal, also can improve and stable hemogram, alleviate or eliminate complication, solves painful, improves the quality of living, delay life.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
Embodiment 1
One treats leukemic Chinese medicine composition, is made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 15 parts, Indigo Naturalis 15 parts, 15 parts, Radix Rehmanniae Preparata, Herba Ecliptae 15 parts, Rhizoma Drynariae 10 parts, Fructus Corni 5 parts, Rhizoma Atractylodis 5 parts, Fructus Schisandrae Chinensis 5 parts, Radix Ginseng 10 parts, the Radix Astragali 10 parts, Radix Angelicae Sinensis 10 parts, 15 parts, Colla Corii Asini, Radix Et Rhizoma Rhei 5 parts, Radix Notoginseng 5 parts, Rhizoma Curcumae 5 parts, Pheretima 5 parts, Cortex Moutan 5 parts, Radix Bupleuri 5 parts, Carapax Trionycis 10 parts, Concha Ostreae 10 parts.
Above-mentioned raw materials is toasted 25min at 220 DEG C, and pulverizer breaks into powder, crosses 80 mesh sieves, after removing residue on sieve, obtains medicated powder, be mixed into powder mud, make pill with Mel or fecula for binding agent and medicated powder.
Embodiment 2
One treats leukemic Chinese medicine composition, is made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 20 parts, Indigo Naturalis 20 parts, 20 parts, Radix Rehmanniae Preparata, Herba Ecliptae 20 parts, Rhizoma Drynariae 15 parts, Fructus Corni 10 parts, Rhizoma Atractylodis 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Ginseng 15 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, 20 parts, Colla Corii Asini, Radix Et Rhizoma Rhei 10 parts, Radix Notoginseng 10 parts, Rhizoma Curcumae 10 parts, Pheretima 10 parts, Cortex Moutan 10 parts, Radix Bupleuri 10 parts, Carapax Trionycis 15 parts, Concha Ostreae 15 parts.
Above-mentioned raw materials is toasted 20min at 230 DEG C, and pulverizer breaks into powder, crosses 80 mesh sieves, removes residue on sieve, obtain medicated powder, incapsulated by medicated powder in shell, to obtain final product.
Embodiment 3
One treats leukemic Chinese medicine composition, is made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 25 parts, Indigo Naturalis 25 parts, 25 parts, Radix Rehmanniae Preparata, Herba Ecliptae 25 parts, Rhizoma Drynariae 20 parts, Fructus Corni 15 parts, Rhizoma Atractylodis 15 parts, Fructus Schisandrae Chinensis 15 parts, Radix Ginseng 20 parts, the Radix Astragali 20 parts, Radix Angelicae Sinensis 20 parts, 25 parts, Colla Corii Asini, Radix Et Rhizoma Rhei 15 parts, Radix Notoginseng 15 parts, Rhizoma Curcumae 15 parts, Pheretima 15 parts, Cortex Moutan 15 parts, Radix Bupleuri 15 parts, Carapax Trionycis 20 parts, Concha Ostreae 20 parts.
Above-mentioned raw materials is toasted 15min at 230 DEG C, and pulverizer breaks into powder, crosses 80 mesh sieves, removes residue on sieve, obtain medicated powder, incapsulated by medicated powder in shell, to obtain final product.
Embodiment 4
One treats leukemic Chinese medicine composition, is made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 18 parts, Indigo Naturalis 21 parts, 23 parts, Radix Rehmanniae Preparata, Herba Ecliptae 25 parts, Rhizoma Drynariae 12 parts, Fructus Corni 12 parts, Rhizoma Atractylodis 8 parts, Fructus Schisandrae Chinensis 6 parts, Radix Ginseng 16 parts, the Radix Astragali 17 parts, Radix Angelicae Sinensis 15 parts, 19 parts, Colla Corii Asini, Radix Et Rhizoma Rhei 14 parts, Radix Notoginseng 7 parts, Rhizoma Curcumae 9 parts, Pheretima 11 parts, Cortex Moutan 5 parts, Radix Bupleuri 15 parts, Carapax Trionycis 12 parts, Concha Ostreae 17 parts.
Above-mentioned raw materials is toasted 15min at 240 DEG C, and pulverizer breaks into powder, crosses 80 mesh sieves, after removing residue on sieve, obtains medicated powder, be mixed into powder mud, make pill with Mel or fecula for binding agent and medicated powder.
Embodiment 5
The present embodiment have selected several typical case:
Case 1: thank certain, man 36 years old, in May, 2006 cases with leukemia, lymph enlargement pain.More than the doctor trained in Western medicine chemotherapy moon, non-symptom management, leukocyte is 18 × 10
9/ L, erythrocyte are 2.7 × 10
12/ L, hemoglobin 68g/L, platelet are 62 × 10
9/ L.The traditional Chinese medical science is examined: Artemusia lactiflora Wall. is yellow, thready and rapid pulse, night sweat, thirsty, cough, fever 39 DEG C heavy, left shoulder left chest pain at night, the swollen bag of left corners of the mouth redness, right shoulder cervical region 2 × 2 ㎝ lymph enlargement pain.The pill made of the compositions taking embodiment 1 15 days, patient's night sweat, thirsty, cough, fever, shoulder chest pain, the swollen bag of the corners of the mouth, all diseases of lymph enlargement pain are all eliminated.The pill that the compositions taking embodiment 1 is made is after 1 month, and leukocyte is 12 × 10
9/ L, erythrocyte are 3 × 10
12/ L, hemoglobin 92g/L, platelet are 80 × 10
9/ L; After continuing to take medicine 3 months, leukocyte is 8 × 10
9/ L, erythrocyte are 3.6 × 10
12/ L, hemoglobin 110g/L, platelet are 132 × 10
9/ L; After continuing to take medicine 6 months, drug withdrawal disease without recurrence, all normal table.
Case 2: Wu, man, 60 years old, in JIUYUE, 2013 cases with leukemia, hepatosplenomegaly tenderness, leukocyte was 8 × 10
9/ L, erythrocyte are 1.9 × 10
12/ L, hemoglobin 80g/L, platelet are 48 × 10
9/ L.The traditional Chinese medical science is examined: body of the tongue is deep red, and tongue is thick in vain, and large pulse is soft, and left arteries and veins is strong, and abdominal distention is heavy for night, tastelessness, and abdominal distention after meal is weak.The capsule made of the compositions that this case takes embodiment 27 days, abdominal distention, weak, tastelessness symptom are improved, and appetite increases, in high spirits; Leukocyte is 8 × 10
9/ L, erythrocyte are 2.1 × 10
12/ L, hemoglobin 82g/L, platelet are 65 × 10
9/ L; Continue to take this capsule 1 month, weak, tastelessness is eliminated, and abdominal distention subtracts greatly, hepatic region, and abdominal swelling hard pine is speeded deliquescing.Continue to take this capsule after 2 months, abdominal distention is not obvious, and liver is the spleen-distension, and large contraction diminishes, and leukocyte is 6 × 10
9/ L, erythrocyte are 2.9 × 10
12/ L, hemoglobin 90g/L, platelet are 85 × 10
9/ L.Continue to take this capsule after 3 months, hepatosplenomegaly reduces 2/3rds, and leukocyte is 5 × 10
9/ L, erythrocyte are 3.5 × 10
12/ L, hemoglobin 109g/L, platelet are 100 × 10
9/ L, body is good for as usual.
Case 3, pays certain, female, 28 years old, in February, 2012, and suffer from acute thrombus type leukemia, menstruation is bled incessantly, and low grade fever does not move back; Leukocyte is 1.9 × 10
9/ L, erythrocyte are 1.7 × 10
12/ L, hemoglobin 65g/L, platelet are 7 × 10
9/ L.Rescued by ground district hospital racing provincial capital Affiliated Hospital of university, transfusion hemostasis of having an injection, namely patient suffers a shock and does not wake up, and then retracts house and cremates.Ask this doctor to look at, faint pulse has jumping, at once acupuncture needle prick in servant, connected valleys two cave, after a few minutes, patient's eye moves the beginning and opens, and suddenly slowly fills with down with hot ginger decoction, and patient revives, but the lower part of the body is still bled and do not stopped.After capsule half a day that the compositions that this case takes embodiment 3 is made, blood does not only flow, and within 3 days, burns afterwards and moves back, from vertical step of can taking food; After taking medicine 1 month, can take care of oneself, leukocyte is 3 × 10
9/ L, erythrocyte are 1.9 × 10
12/ L, hemoglobin 80g/L, platelet are 30 × 10
9/ L.Though patient comes back to life, bleed too much because of former eventually, consume vigour greatly, life delays more than 4 months.
Case 4, Chen, man, 17 years old, in November, 2013, cases with leukemia, fever 39C, unbearably, leukocyte was 0.9 × 10 in toothache
9/ L, erythrocyte are 1.9 × 10
12/ L, hemoglobin 60g/L, platelet are 9 × 10
9/ L.The doctor trained in Western medicine chemotherapy several months, toothache hyperpyrexia is more than, and hemogram, without liter, sustains life by blood transfusion entirely.The pill made of the compositions that this case takes embodiment 46 days, toothache removes, and within 10 days, burns to move back as usual, and after 1 month, leukocyte is 2 × 10
9/ L, erythrocyte are 1.9 × 10
12/ L, hemoglobin 70g/L, platelet are 40 × 10
9/ L, Be very effective.
Embodiment 6
Compliance test result is tested
1. case selection:
Choose 200 examples and come from traditional Chinese medical science difficult disease subject study base, Station City, Zhumadian City, wherein, 160 examples are diagnosed as leukemia people in late period; 40 examples are diagnosed as early, mid-term leukemia people, be divided into four groups at random, and often organize all containing 40 example leukemia people in late period and 10 example morning, mid-term leukemia people;
2. test method:
The medicine that the embodiment of the present invention 1,2,3,4 provides is taken respectively to four groups of patients, called after " embodiment 1 group ", " embodiment 2 groups ", " embodiment 3 groups ", " embodiment 4 groups " respectively, every day is early, middle and late to be serviced once, namely three times are taken every day, 30 days courses for the treatment of, treat 1-12 the course for the treatment of continuously according to state of an illness weight;
3. curative effect judging standard:
Effective: because of unfavorable symptoms such as the anemia caused by leukemia, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pains, to alleviate or partial symptoms disappears; Leukocyte, erythrocyte, hemoglobin, platelet can be made to tend to normal, or it is normal to reach recovery.
Cure: eliminate because of unfavorable symptoms such as the anemia caused by leukemia, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pains; Recover leukocyte, erythrocyte, hemoglobin, hematoblastic normal data, drug withdrawal is not recurred.
4. result of the test:
Wherein, the patient consumes of early stage mild symptoms 7 days, severe one 1-2 month, the individual month unfavorable symptom of severe patient 3-6 alleviates or partial symptoms disappears or cures completely; Leukocyte, erythrocyte, hemoglobin, platelet partial data trend is normal to be recovered, or up to standard, or all data all recover up to standard, and after healing person's drug withdrawal, symptom is without recurrence completely, and leukocyte, erythrocyte, hemoglobin, platelet count are according to stably reaching standard.Its concrete statistical data is as shown in table 1:
The effect test result of the medicine that table 1 embodiment of the present invention 1-4 provides
| Embodiment 1 group | Embodiment 2 groups | Embodiment 3 groups | Embodiment 4 groups | |
| Effective number of cases (late period) | 35 | 37 | 36 | 35 |
| Effective number of cases (early, mid-term) | 10 | 10 | 10 | 10 |
| Total effective rate | 90% | 94% | 92% | 90% |
| Cure number of cases (early, mid-term) | 6 | 7 | 5 | 6 |
| Early, mid-term cure rate | 60% | 70% | 50% | 60% |
As can be seen from table 1 and embodiment 5, its treatment of oral traditional Chinese medicine composition provided by the invention is simple, safety, light no pain, expense are low, and curative effect is fast good again, stable lasting.To leukemia early, mid-term patient, take medicine about 10 days, hemogram and disease all can be improved, 1-3 month symptom management, and cure about half a year to 1 year, drug withdrawal is not recurred.To patients with terminal, also can improve and stable hemogram, alleviate or eliminate complication, solve painful, improve the quality of living, delay life.There is significant progressive and practical value.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat a leukemic Chinese medicine composition, it is characterized in that, be made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 15-25 part, Indigo Naturalis 15-25 part, Radix Rehmanniae Preparata 15-25 part, Herba Ecliptae 15-25 part, Rhizoma Drynariae 10-20 part, Fructus Corni 5-15 part, Rhizoma Atractylodis 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Radix Ginseng 10-20 part, Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Colla Corii Asini 15-25 part, Radix Et Rhizoma Rhei 5-15 part, Radix Notoginseng 5-15 part, Rhizoma Curcumae 5-15 part, Pheretima 5-15 part, Cortex Moutan 5-15 part, Radix Bupleuri 5-15 part, Carapax Trionycis 10-20 part, Concha Ostreae 10-20 part.
2. the leukemic Chinese medicine composition for the treatment of according to claim 1, is characterized in that, is made up of the raw material of following weight portion:
Herba Hedyotidis Diffusae 20 parts, Indigo Naturalis 20 parts, 20 parts, Radix Rehmanniae Preparata, Herba Ecliptae 20 parts, Rhizoma Drynariae 15 parts, Fructus Corni 10 parts, Rhizoma Atractylodis 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Ginseng 15 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, 20 parts, Colla Corii Asini, Radix Et Rhizoma Rhei 10 parts, Radix Notoginseng 10 parts, Rhizoma Curcumae 10 parts, Pheretima 10 parts, Cortex Moutan 10 parts, Radix Bupleuri 10 parts, Carapax Trionycis 15 parts, Concha Ostreae 15 parts.
3. adopt the acceptable clinically preparation that the compositions of claim 1 or 2 is made.
4. preparation according to claim 3, is characterized in that: described preparation is capsule.
5. the preparation method of capsule according to claim 4, is characterized in that: after being toasted by raw material, pulverize, cross 80 mesh sieves, obtain medicated powder, incapsulate in shell, to obtain final product described medicated powder.
6. the preparation method of capsule according to claim 5, is characterized in that, baking temperature is 220-240 DEG C, and baking time is 15-25min.
7. preparation according to claim 3, is characterized in that: described preparation is pill.
8. the preparation method of pill according to claim 7, is characterized in that: after being toasted by raw material, pulverize, cross 80 mesh sieves, obtain medicated powder, add binding agent mix homogeneously, be then pressed into pill, to obtain final product in described medicated powder.
9. the preparation method of pill according to claim 8, is characterized in that, baking temperature is 220-240 DEG C, and baking time is 15-25min.
10. the application of compositions in the leukemic medicine of preparation treatment of claim 1 or 2.
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| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1390588A (en) * | 2002-08-06 | 2003-01-15 | 王凯 | Composite medicine for treating leukemia |
| CN1879841A (en) * | 2006-05-17 | 2006-12-20 | 郭富红 | A Chinese medicine for treating leukemia |
-
2014
- 2014-02-19 CN CN201410056222.5A patent/CN103736038B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1390588A (en) * | 2002-08-06 | 2003-01-15 | 王凯 | Composite medicine for treating leukemia |
| CN1879841A (en) * | 2006-05-17 | 2006-12-20 | 郭富红 | A Chinese medicine for treating leukemia |
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| CN103736038A (en) | 2014-04-23 |
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