CN109620929A - A kind of green blood traditional Chinese medicine oral liquid and its preparation method and application - Google Patents
A kind of green blood traditional Chinese medicine oral liquid and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of green blood traditional Chinese medicine oral liquids, are prepared by the primary raw material of following parts by weight: 80-100 parts of Chinese medicine preparation, 20-26 parts of ferrous fumarate gel solution, 3-5 parts of sodium-iron-chlorophyllin, 0.3-0.5 parts of vitamin C, 10-12 parts of sucrose, 0.05-0.06 parts of ethylparaben, 2-3 parts of ethyl alcohol；The invention also discloses the preparation method and applications of the green blood traditional Chinese medicine oral liquid.The present invention passes through using Traditional Chinese medicine formula preparation as the main component of oral solution, it is added to appropriate ferrous fumarate gel solution, and it is aided with sodium-iron-chlorophyllin and vitamin C, vitamin C can promote absorption of the human body to ferro element in ferrous fumarate, the green blood oral solution being prepared can be with enriching yin and nourishing kidney, qi-supplementing, blood-engendering, promoting blood circulation and hemostasis, for having significant curative effect on the Anemias such as aplastic anemia, hypoferric anemia, malnutritive anaemia, hemolytic anemia, anemia of chronic disease, thrombopenia, leukopenia.
Description
Technical field
The invention belongs to field of medicine preparations, and in particular, to a kind of green blood traditional Chinese medicine oral liquid and preparation method thereof and answer
With.
Background technique
Anaemia disease (including aplastic anemia) thinks to belong to " deficiency of blood, consumptive disease " scope in Chinese medicine, and the interpretation of the cause, onset and process of an illness is in spleen kidney, because spleen is united
The raw marrow of blood, Shen controls bone, bone.Then marrow loses and the anaemia that arrives kidney deficiency person.Therefore, which starts with from kidney tonifying, screens meticulously
The rare authentic medicinal herbs such as red ginseng, Radix Astragali, donkey-hide gelatin, pilose antler, make it have significant enriching yin and nourishing kidney, warming and invigorating kidney Yang, promoting blood circulation, cool blood,
Hemostasis, qi-blood tonifying unique effects, incur suitable for qi-blood deficiency " kidney-yin deficiency, kidney-yang deficiency, the kidney yin deficiency of yang, kidney insufficiency,
The diseases type such as insufficiency of both the spleen and the kindey, the deficiency of liver-yin and kidney-yin ".The Chinese materia medica preparation of existing treatment aplastic anemia, curative effect is single, and cure rate is low, especially
It is that cannot treat a variety of anaemia diseases simultaneously.
Summary of the invention
The purpose of the present invention is to provide a kind of green blood traditional Chinese medicine oral liquids and its preparation method and application, by being matched with Chinese medicine
Square preparation is the main component of oral solution, is added to appropriate ferrous fumarate gel solution, and be aided with sodium-iron-chlorophyllin and dimension
Raw element C, vitamin C can promote human body to the absorption of ferro element in ferrous fumarate, and the green blood oral solution being prepared can be with
Enriching yin and nourishing kidney, qi-supplementing, blood-engendering, promoting blood circulation and hemostasis, for aplastic anemia, hypoferric anemia, malnutritive anaemia, hemolytic anemia, slow
There is significant curative effect on the Anemias such as venereal disease anaemia, thrombopenia, leukopenia.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of green blood traditional Chinese medicine oral liquid, is prepared by the primary raw material of following parts by weight: 80-100 parts of Chinese medicine preparation, richness
Horse acid ferrous 20-26 parts of gel solution, 3-5 parts of sodium-iron-chlorophyllin, 0.3-0.5 parts of vitamin C, 10-12 parts of sucrose, nipalgin
0.05-0.06 parts of ethyl ester, 2-3 parts of ethyl alcohol；
The green blood traditional Chinese medicine oral liquid is prepared by following steps:
Step S1, Rehmannia glutinosa, deer horn glue, fructus lycii, radix rehmanniae recen, the mountain cornel in Chinese medicine preparation are weighed according to quality proportioning
Meat, Radix Angelicae Sinensis, Semen Cuscutae, Morinda officinalis, Radix Astragali, rhizoma polygonati, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Poria cocos, fructus amomi, dried orange peel, American Ginseng, Radix Codonopsis, Radix Salviae Miltiorrhizae, chicken
Blood rattan, rhizoma imperatae are dried, crush, and 3-5 times of the total weight distilled water measured is added, first impregnates 30min, and reheating is boiled, and protect
It holds slightly boiled state to decoct 2-2.5 hours, adds the distilled water of 2 times of amounts that the dregs of a decoction are decocted 1- under identical condition again after coarse filtration
1.5 hours, secondary medical fluid is merged after filtering, is concentrated, being concentrated into specific gravity is 1-1.5, obtains concentrated extracting solution；
Step S2, the distilled water for weighing 1.5 times of sucrose weight, is heated and boils, sucrose is added inward, is keeping slightly boiled
Infusion 30-36min under state, is made syrup；
Step S3, ethylparaben is added in ethyl alcohol, stirring makes it completely dissolved, and obtains ethylparaben solution；
Step S4, ferrous fumarate gel solution, vitamin C, syrup is added in concentrated extracting solution made from the step S1
It with ethylparaben solution, is uniformly mixed, green blood traditional Chinese medicine oral liquid is made.
Further, the Chinese medicine preparation includes the Chinese medicine material of following parts by weight: 40-50 parts of Rehmannia glutinosa, deer horn glue 36-
42 parts, 30-40 parts of fructus lycii, 15-20 parts of radix rehmanniae recen, 16-18 parts of pulp of dogwood fruit, 15-20 parts of Radix Angelicae Sinensis, 16-18 parts of Semen Cuscutae, Morinda offcinalis How
Its 12-16 parts, 16-18 parts of Radix Astragali, 15-18 parts of rhizoma polygonati, Radix Ophiopogonis 12-16 part, 12-16 parts of Rhizoma Atractylodis Macrocephalae, 12-15 parts of Poria cocos, fructus amomi 12-
15 parts, 12-15 parts of dried orange peel, 16-18 parts of American Ginseng, 12-15 parts of Radix Codonopsis, 15-18 parts of Radix Salviae Miltiorrhizae, 16-20 parts of Caulis Spatholobi, rhizoma imperatae 8-
10 parts.
Further, the ferrous fumarate gel solution is prepared by the following method:
(1) gellan gum is weighed respectively and low-viscosity sodium alginate is dissolved in distilled water, and being configured to mass fraction is 0.4%
Gellan gum solution and 0.2% low-viscosity sodium alginate soln, two kinds of solution are uniformly mixed according to volume ratio for 1:1, be made
Matrix solution, it is spare；
(2) Emulsifier EL-60 and diethylene glycol monoethyl ether are uniformly mixed according to quality proportioning, obtain special table
Face activating agent；
(3) ferrous fumarate is dissolved in glyceryl triacetate according to quality proportioning, sequentially adds tailored surfaces inward
Activating agent and matrix solution, under normal temperature condition, magnetic agitation is uniform, obtains transparent clear ferrous fumarate gel solution.
Further, the ferrous fumarate, glyceryl triacetate, Emulsifier EL-60, diethylene glycol monoethyl ether,
The mass ratio of matrix solution is 0.5:4.5:5:5:80.
A kind of preparation method of green blood traditional Chinese medicine oral liquid, includes the following steps:
Step S1, Rehmannia glutinosa, deer horn glue, fructus lycii, radix rehmanniae recen, the mountain cornel in Chinese medicine preparation are weighed according to quality proportioning
Meat, Radix Angelicae Sinensis, Semen Cuscutae, Morinda officinalis, Radix Astragali, rhizoma polygonati, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Poria cocos, fructus amomi, dried orange peel, American Ginseng, Radix Codonopsis, Radix Salviae Miltiorrhizae, chicken
Blood rattan, rhizoma imperatae are dried, crush, and 3-5 times of the total weight distilled water measured is added, first impregnates 30min, and reheating is boiled, and protect
It holds slightly boiled state to decoct 2-2.5 hours, adds the distilled water of 2 times of amounts that the dregs of a decoction are decocted 1- under identical condition again after coarse filtration
1.5 hours, secondary medical fluid is merged after filtering, is concentrated, being concentrated into specific gravity is 1-1.5, obtains concentrated extracting solution；
Step S2, the distilled water for weighing 1.5 times of sucrose weight, is heated and boils, sucrose is added inward, is keeping slightly boiled
Infusion 30-36min under state, is made syrup；
Step S3, ethylparaben is added in ethyl alcohol, stirring makes it completely dissolved, and obtains ethylparaben solution；
Step S4, ferrous fumarate gel solution, vitamin C, syrup is added in concentrated extracting solution made from the step S1
It with ethylparaben solution, is uniformly mixed, green blood traditional Chinese medicine oral liquid is made.
The green blood traditional Chinese medicine oral liquid is in preparation treatment aplastic anemia, hypoferric anemia, malnutritive anaemia, hemolytic
Application in terms of anaemia, anemia of chronic disease, thrombopenia, oligoleukocythemia disease drug.
Beneficial effects of the present invention:
(1) present invention is using Traditional Chinese medicine formula preparation as the main component of oral solution, and the Chinese medicine preparation is with kidney tonifying, essence replenishing drug
Based on (Rehmannia glutinosa, deer horn glue, fructus lycii), using flat tonifying yin sun as principle in terms of medicament selection, all selection pharmacological property it is relatively flat and
Object, prevent the sticky retardance mechanism of qi of Yin-nourishing drug, it is (Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, Poria cocos, fructus amomi, old to be also suitably added regulating qi-flowing for harmonizing stomach drug
Skin, American Ginseng, Radix Codonopsis), regulating functional activities of qi, to help transporting；Nourishing yin and nourishing blood drug is worked in coordination with kidney warming and Yang tonifying drug, it is intended that yin-yang
It mutually breeds, the meaning of the mutual length of tonifying both YIN and YANG, mutual assistance；Kidney tonifying, essence replenishing medicine is reused in we, according to dialectical selection nourishing kidney-yin medicine and temperature
Kidney yang medicine, mutual compatibility mutually grow the effect of mutually promoting in the hope of the bright giving young employees remedial-courses in general knowledge and vocational skills of yin；The compatibilities such as fructus amomi, dried orange peel are in the tonic of group, reason
Gas stomach function regulating is mended without stagnant, the gas of invigorating the spleen and stomach；In we fructus amomi can not only promoting the circulation of qi more can dampness elimination, the product long term usage of sugariness easily give birth to it is wet,
Damp pathogen obstruction the spleen is easier to cause the dysfunction of the spleen in transport；A variety of anemic disorders can be effectively treated with enriching yin and nourishing kidney, qi-supplementing, blood-engendering, promoting blood circulation and hemostasis；
(2) present invention is aided with ferrous fumarate gel solution in oral solution, with 0.4% gellan gum and 0.2% low-viscosity
Matrix solution made from sodium alginate is ion-sensitive type situ-gel matrix, with hydrophily tridimensional network and uniqueness
Solution-gel property of transition, the carrier by ion-sensitive type situ-gel matrix as ferrous fumarate, obtained rich horse
Sour ferrous iron gel solution exists in vitro with the liquid form of low-viscosity, sends out immediately under the action of cation in gastric juice after oral
Raw phase transition forms semi-solid gel preparation, and the positioning of control drug and sustained release are put, and improves the characteristics of pharmacokinetics of ferrous fumarate；
Ferrous fumarate is a kind of novel soluble chalybeate, and iron-content up to 32%, stablize, and is not easy to be oxidized by property, and fumaric acid is sub-
Iron intestinal absorption rate is 4-5 times of ferrous sulfate, has preferable compatibility with antibiotic and vitamin, immunity of organism can be improved
Power；Ferrous fumarate is western medicine composition, and hematopoiesis raw material can be provided for human body；The vitamin C contained in oral liquid prescription can promote
Chalybeate absorbs, and improves effect of enriching blood；
(3) it is molten to be added to appropriate ferrous fumarate gel using Traditional Chinese medicine formula preparation as the main component of oral solution by the present invention
Liquid, and it is aided with sodium-iron-chlorophyllin and vitamin C, sodium-iron-chlorophyllin structure is closely similar with haematoporphyrin, belongs to organic porphyrin
Iron and natural porphyrin iron not only have effects that blood-enrich, while to promotion marrow erythroid progenitor cells and Granulocyte-macrophage progenitor cell
Proliferation, promote the recovery of red blood cell and hemoglobin and granulophilocyte, improve the saturation of ferro concentration in serum and transferrins
Degree also has remarkable effect；Vitamin C can promote human body to the absorption of ferro element in ferrous fumarate, the green blood being prepared
Oral solution can be with enriching yin and nourishing kidney, qi-supplementing, blood-engendering, promoting blood circulation and hemostasis, for aplastic anemia, hypoferric anemia, malnutritive anaemia, molten
There is significant curative effect on the Anemias such as hemolytic hemolytic anemia, anemia of chronic disease, thrombopenia, leukopenia.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff all other embodiment obtained without creative efforts belongs to what the present invention protected
Range.
A kind of green blood traditional Chinese medicine oral liquid, is prepared by the primary raw material of following parts by weight: 80-100 parts of Chinese medicine preparation, richness
Horse acid ferrous 20-26 parts of gel solution, 3-5 parts of sodium-iron-chlorophyllin, 0.3-0.5 parts of vitamin C, 10-12 parts of sucrose, nipalgin
0.05-0.06 parts of ethyl ester, 2-3 parts of ethyl alcohol；
It is also needed in the preparation process of oral solution using to a large amount of distilled water；
Sodium-iron-chlorophyllin structure is closely similar with haematoporphyrin, belongs to organic PORPHYRIN IRON and natural porphyrin iron, not only has
Blood-enrich effect, while to the proliferation for promoting marrow erythroid progenitor cells and Granulocyte-macrophage progenitor cell, promote red blood cell and blood red
The recovery of albumen and granulophilocyte, the saturation degree for improving ferro concentration in serum and transferrins also have remarkable effect；
The Chinese medicine preparation includes the Chinese medicine material of following parts by weight: 40-50 parts of Rehmannia glutinosa, 36-42 parts of deer horn glue, fructus lycii
30-40 parts sub-, 15-20 parts of radix rehmanniae recen, 16-18 parts of pulp of dogwood fruit, 15-20 parts of Radix Angelicae Sinensis, 16-18 parts of Semen Cuscutae, Morinda officinalis 12-16
It is part, 16-18 parts of Radix Astragali, 15-18 parts of rhizoma polygonati, Radix Ophiopogonis 12-16 part, 12-16 parts of Rhizoma Atractylodis Macrocephalae, 12-15 parts of Poria cocos, 12-15 parts of fructus amomi, old
12-15 parts of skin, 16-18 parts of American Ginseng, 12-15 parts of Radix Codonopsis, 15-18 parts of Radix Salviae Miltiorrhizae, 16-20 parts of Caulis Spatholobi, 8-10 parts of rhizoma imperatae；
The Chinese medicine preparation based on kidney tonifying, essence replenishing drug (Rehmannia glutinosa, deer horn glue, fructus lycii), in terms of medicament selection with
Flat tonifying yin sun is principle, all selects the object of the relatively flat sum of pharmacological property, prevents the sticky retardance mechanism of qi of Yin-nourishing drug, be also suitably added reason
Gas stomach function regulating drug (Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, Poria cocos, fructus amomi, dried orange peel, American Ginseng, Radix Codonopsis), regulating functional activities of qi, to help transporting；Nourishing yin and nourishing blood medicine
Object is worked in coordination with kidney warming and Yang tonifying drug, it is intended that yin-yang is mutually bred, the meaning of the mutual length of tonifying both YIN and YANG, mutual assistance；It reuses and mends in we
Kidney replenishing essence medicine, according to dialectical selection nourishing kidney-yin medicine and warm kidney sun medicine, mutual compatibility mutually grows the effect of mutually promoting in the hope of the bright giving young employees remedial-courses in general knowledge and vocational skills of yin；
The most matter profit of nourishing kidney-yin drug, sweet in flavor, a lot of nourshing kidneys, the effect of benefiting yin, green blood, for the main medicine for treating kidney yin deficiency type marrow labor disease
Object, if but the bad patient of spleen and stomach function, easily grow it is greasy hinder stomach to weaken spleen fortune function further, therefore ought suitably increase invigorating the spleen and
The dosage of stomach medicine object, function of spleen and stomach regulating, could preferably in the side of performance drug effect；The drug of warm kidney sun, multiselect medication are warm-natured
The product of sum, adopt its it is slow mend be that gradually kidney-replenishing, sun help negative life, and essence and blood gradually fills, therefore do not advocate using the attached equal easily consumption impairment of yin blood of ginger it
Product, the generation of blood also needs the cooperation of other internal organs in addition to kidney essense, such as the effect of liver and spleen；Blood stored in the liver, The spleen governs the blood, the two is in green blood
Vital status is all played in terms of promoting circulation of blood, therefore pays attention to soothing liver and strengthening spleen；Though it is weak for another the power of Radix Angelicae Sinensis kidney tonifying, the heart can be nourished
Blood, liver blood, flat tonifying lung spleen kidney three is dirty, and the effect in we is auxiliary kidney-reinforcing drug object, plays the role of green blood jointly, and have rush
Raw tangible invisible generation totally 5, and qi and blood interacts, money life mutually, the metaplasia hematologic effects if ying-qi virtual loss, and it is tangible it
Blood is difficult to quickly breed, and tonifying Qi person it is opposite be easier to it is some be also easier to solve the matter of great urgency, so when the deficiency of blood, using Qi-tonifying drug
Be it is necessary, join outside stilbene in grass center, three gas mend altogether, and tonifying Qi is with green blood, and tonifying Qi also has system blood to consolidate the function of table, makes blood
Being photographed in arteries and veins prevents from overflowing outside arteries and veins, and exopathogen is not easy to invade；The compatibilities such as fructus amomi, dried orange peel are in the tonic of group, regulating qi-flowing for harmonizing stomach
It mends without stagnant, the gas of invigorating the spleen and stomach；In we fructus amomi can not only promoting the circulation of qi more can dampness elimination, the product long term usage of sugariness is easily given birth to wet, and damp evil is tired
Spleen is easier to cause the dysfunction of the spleen in transport；
The ferrous fumarate gel solution is prepared by the following method:
(1) gellan gum is weighed respectively and low-viscosity sodium alginate is dissolved in distilled water, and being configured to mass fraction is 0.4%
Gellan gum solution and 0.2% low-viscosity sodium alginate soln, two kinds of solution are uniformly mixed according to volume ratio for 1:1, be made
Matrix solution, it is spare；
(2) Emulsifier EL-60 and diethylene glycol monoethyl ether are uniformly mixed according to quality proportioning, obtain special table
Face activating agent；
(3) ferrous fumarate is dissolved in glyceryl triacetate according to quality proportioning, sequentially adds tailored surfaces inward
Activating agent and matrix solution, under normal temperature condition, magnetic agitation is uniform, obtains transparent clear ferrous fumarate gel solution；
Wherein, ferrous fumarate, glyceryl triacetate, Emulsifier EL-60, diethylene glycol monoethyl ether, matrix solution
Mass ratio be 0.5:4.5:5:5:80；
Matrix solution made from 0.4% gellan gum and 0.2% low-viscosity sodium alginate is ion-sensitive type situ-gel base
Matter has hydrophily tridimensional network and unique solution-gel property of transition, passes through ion-sensitive type situ-gel matrix
As the carrier of ferrous fumarate, obtained ferrous fumarate gel solution exists in vitro with the liquid form of low-viscosity, mouth
Phase transition occurs after clothes under the action of cation immediately in gastric juice, forms semi-solid gel preparation, control drug positions and delays
Release, improves the characteristics of pharmacokinetics of ferrous fumarate；Ferrous fumarate is western medicine composition, and hematopoiesis raw material can be provided for human body；It is rich
Horse acid ferrous iron is a kind of novel soluble chalybeate, and iron-content up to 32%, stablize, and is not easy to be oxidized, ferrous fumarate by property
Intestinal absorption rate is 4-5 times of ferrous sulfate, has preferable compatibility with antibiotic and vitamin, immunity of organisms can be improved；
The vitamin C contained in oral liquid prescription can promote chalybeate absorption, improve effect of enriching blood；
The preparation method of the green blood traditional Chinese medicine oral liquid, includes the following steps:
Step S1, Rehmannia glutinosa, deer horn glue, fructus lycii, radix rehmanniae recen, the mountain cornel in Chinese medicine preparation are weighed according to quality proportioning
Meat, Radix Angelicae Sinensis, Semen Cuscutae, Morinda officinalis, Radix Astragali, rhizoma polygonati, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Poria cocos, fructus amomi, dried orange peel, American Ginseng, Radix Codonopsis, Radix Salviae Miltiorrhizae, chicken
Blood rattan, rhizoma imperatae are dried, crush, and 3-5 times of the total weight distilled water measured is added, first impregnates 30min, and reheating is boiled, and protect
It holds slightly boiled state to decoct 2-2.5 hours, overflows various effective ingredients in raw material sufficiently under high temperature infusion, after coarse filtration
Again plus the distilled water of 2 times of amounts decocts the dregs of a decoction 1-1.5 hours under identical condition, and secondary medical fluid is merged after filtering, is carried out
Concentration, being concentrated into specific gravity is 1-1.5, obtains concentrated extracting solution；
Step S2, the distilled water for weighing 1.5 times of sucrose weight, is heated and boils, sucrose is added inward, is keeping slightly boiled
Infusion 30-36min under state, is made syrup；
Step S3, ethylparaben is added in ethyl alcohol, stirring makes it completely dissolved, and obtains ethylparaben solution；
Step S4, ferrous fumarate gel solution, vitamin C, syrup is added in concentrated extracting solution made from the step S1
It with ethylparaben solution, is uniformly mixed, green blood traditional Chinese medicine oral liquid is made；
The green blood traditional Chinese medicine oral liquid is poor in preparation treatment aplastic anemia, hypoferric anemia, malnutritive anaemia, hemolytic
Application in terms of blood, anemia of chronic disease, thrombopenia, oligoleukocythemia disease drug.
Embodiment 1
A kind of green blood traditional Chinese medicine oral liquid, is prepared by the primary raw material of following parts by weight: 80 parts of Chinese medicine preparation, fumaric acid
20 parts of ferrous gel solution, 3 parts of sodium-iron-chlorophyllin, 0.3 part of vitamin C, 10 parts of sucrose, 0.05 part of ethylparaben, ethyl alcohol
2 parts；
The Chinese medicine preparation includes the Chinese medicine material of following parts by weight: 40 parts of Rehmannia glutinosa, 36 parts of deer horn glue, fructus lycii 30
Part, 15 parts of radix rehmanniae recen, 16 parts of pulp of dogwood fruit, 15 parts of Radix Angelicae Sinensis, 16 parts of Semen Cuscutae, 12 parts of Morinda officinalis, 16 parts of Radix Astragali, 15 parts of rhizoma polygonati, wheat
12 parts of winter, 12 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of Poria cocos, 12 parts of fructus amomi, 12 parts of dried orange peel, 16 parts of American Ginseng, 12 parts of Radix Codonopsis, 15 parts of Radix Salviae Miltiorrhizae, chicken blood
16 parts of rattan, 8 parts of rhizoma imperatae.
Embodiment 2
A kind of green blood traditional Chinese medicine oral liquid, is prepared by the primary raw material of following parts by weight: 90 parts of Chinese medicine preparation, fumaric acid
23 parts of ferrous gel solution, 4 parts of sodium-iron-chlorophyllin, 0.4 part of vitamin C, 11 parts of sucrose, 0.055 part of ethylparaben, second
2.5 parts of alcohol；
The Chinese medicine preparation includes the Chinese medicine material of following parts by weight: 45 parts of Rehmannia glutinosa, 39 parts of deer horn glue, fructus lycii 35
Part, 18 parts of radix rehmanniae recen, 17 parts of pulp of dogwood fruit, 18 parts of Radix Angelicae Sinensis, 17 parts of Semen Cuscutae, 14 parts of Morinda officinalis, 17 parts of Radix Astragali, 16 parts of rhizoma polygonati, wheat
14 parts of winter, 14 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of Poria cocos, 13 parts of fructus amomi, 14 parts of dried orange peel, 17 parts of American Ginseng, 13 parts of Radix Codonopsis, 16 parts of Radix Salviae Miltiorrhizae, chicken blood
18 parts of rattan, 9 parts of rhizoma imperatae.
Embodiment 3
A kind of green blood traditional Chinese medicine oral liquid, is prepared by the primary raw material of following parts by weight: 100 parts of Chinese medicine preparation, rich horse
Sour ferrous iron 26 parts of gel solution, 5 parts of sodium-iron-chlorophyllin, 0.5 part of vitamin C, 12 parts of sucrose, 0.06 part of ethylparaben, second
3 parts of alcohol；
The Chinese medicine preparation includes the Chinese medicine material of following parts by weight: 50 parts of Rehmannia glutinosa, 42 parts of deer horn glue, fructus lycii 40
Part, 20 parts of radix rehmanniae recen, 18 parts of pulp of dogwood fruit, 20 parts of Radix Angelicae Sinensis, 18 parts of Semen Cuscutae, 16 parts of Morinda officinalis, 18 parts of Radix Astragali, 18 parts of rhizoma polygonati, wheat
16 parts of winter, 16 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 15 parts of fructus amomi, 15 parts of dried orange peel, 18 parts of American Ginseng, 15 parts of Radix Codonopsis, 18 parts of Radix Salviae Miltiorrhizae, chicken blood
20 parts of rattan, 10 parts of rhizoma imperatae.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment
All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification,
It can make many modifications and variations.These embodiments are chosen and specifically described to this specification, is in order to better explain the present invention
Principle and practical application, so that skilled artisan be enable to better understand and utilize the present invention.The present invention is only
It is limited by claims and its full scope and equivalent.
Claims (6)
1. a kind of green blood traditional Chinese medicine oral liquid, which is characterized in that be prepared by the primary raw material of following parts by weight: Chinese medicine preparation
80-100 parts, 20-26 parts of ferrous fumarate gel solution, 3-5 parts of sodium-iron-chlorophyllin, 0.3-0.5 parts of vitamin C, sucrose
10-12 parts, 0.05-0.06 parts of ethylparaben, 2-3 parts of ethyl alcohol；
The green blood traditional Chinese medicine oral liquid is prepared by following steps:
Step S1, weighed according to quality proportioning Rehmannia glutinosa in Chinese medicine preparation, deer horn glue, fructus lycii, radix rehmanniae recen, pulp of dogwood fruit, when
Return, Semen Cuscutae, Morinda officinalis, Radix Astragali, rhizoma polygonati, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Poria cocos, fructus amomi, dried orange peel, American Ginseng, Radix Codonopsis, Radix Salviae Miltiorrhizae, Caulis Spatholobi,
Rhizoma imperatae is dried, crushes, and 3-5 times of the total weight distilled water measured is added, first impregnates 30min, and reheating is boiled, and keeps micro-
The state of boiling decocts 2-2.5 hours, adds the distilled water of 2 times of amounts that the dregs of a decoction are decocted to 1-1.5 under identical condition after coarse filtration again small
When, secondary medical fluid is merged after filtering, is concentrated, being concentrated into specific gravity is 1-1.5, obtains concentrated extracting solution；
Step S2, the distilled water for weighing 1.5 times of sucrose weight, is heated and boils, sucrose is added inward, is keeping slight boiling condition
Lower infusion 30-36min, is made syrup；
Step S3, ethylparaben is added in ethyl alcohol, stirring makes it completely dissolved, and obtains ethylparaben solution；
Step S4, ferrous fumarate gel solution, vitamin C, syrup and Buddhist nun is added in concentrated extracting solution made from the step S1
Golden ethyl ester solution is moored, is uniformly mixed, green blood traditional Chinese medicine oral liquid is made.
2. a kind of green blood traditional Chinese medicine oral liquid according to claim 1, which is characterized in that the Chinese medicine preparation includes following weight
Measure the Chinese medicine material of part: 40-50 parts of Rehmannia glutinosa, 36-42 parts of deer horn glue, 30-40 parts of fructus lycii, 15-20 parts of radix rehmanniae recen, pulp of dogwood fruit
16-18 parts, 15-20 parts of Radix Angelicae Sinensis, 16-18 parts of Semen Cuscutae, 12-16 parts of Morinda officinalis, 16-18 parts of Radix Astragali, 15-18 parts of rhizoma polygonati, Radix Ophiopogonis
12-16 parts, 12-16 parts of Rhizoma Atractylodis Macrocephalae, 12-15 parts of Poria cocos, 12-15 parts of fructus amomi, 12-15 parts of dried orange peel, 16-18 parts of American Ginseng, Radix Codonopsis 12-
15 parts, 15-18 parts of Radix Salviae Miltiorrhizae, 16-20 parts of Caulis Spatholobi, 8-10 parts of rhizoma imperatae.
3. a kind of green blood traditional Chinese medicine oral liquid according to claim 1, which is characterized in that the ferrous fumarate gel solution
It prepares by the following method:
(1) gellan gum is weighed respectively and low-viscosity sodium alginate is dissolved in distilled water, and it is cold to be configured to the knot that mass fraction is 0.4%
Sol solution and 0.2% low-viscosity sodium alginate soln, two kinds of solution are uniformly mixed according to volume ratio for 1:1, be made matrix
Solution, it is spare；
(2) Emulsifier EL-60 and diethylene glycol monoethyl ether are uniformly mixed according to quality proportioning, it is living obtains tailored surfaces
Property agent；
(3) ferrous fumarate is dissolved in glyceryl triacetate according to quality proportioning, sequentially adds tailored surfaces activity inward
Agent and matrix solution, under normal temperature condition, magnetic agitation is uniform, obtains transparent clear ferrous fumarate gel solution.
4. a kind of green blood traditional Chinese medicine oral liquid according to claim 3, which is characterized in that the ferrous fumarate, triacetic acid
Glyceride, Emulsifier EL-60, diethylene glycol monoethyl ether, the mass ratio of matrix solution are 0.5:4.5:5:5:80.
5. a kind of preparation method of green blood traditional Chinese medicine oral liquid, which comprises the steps of:
Step S1, weighed according to quality proportioning Rehmannia glutinosa in Chinese medicine preparation, deer horn glue, fructus lycii, radix rehmanniae recen, pulp of dogwood fruit, when
Return, Semen Cuscutae, Morinda officinalis, Radix Astragali, rhizoma polygonati, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae, Poria cocos, fructus amomi, dried orange peel, American Ginseng, Radix Codonopsis, Radix Salviae Miltiorrhizae, Caulis Spatholobi,
Rhizoma imperatae is dried, crushes, and 3-5 times of the total weight distilled water measured is added, first impregnates 30min, and reheating is boiled, and keeps micro-
The state of boiling decocts 2-2.5 hours, adds the distilled water of 2 times of amounts that the dregs of a decoction are decocted to 1-1.5 under identical condition after coarse filtration again small
When, secondary medical fluid is merged after filtering, is concentrated, being concentrated into specific gravity is 1-1.5, obtains concentrated extracting solution；
Step S2, the distilled water for weighing 1.5 times of sucrose weight, is heated and boils, sucrose is added inward, is keeping slight boiling condition
Lower infusion 30-36min, is made syrup；
Step S3, ethylparaben is added in ethyl alcohol, stirring makes it completely dissolved, and obtains ethylparaben solution；
Step S4, ferrous fumarate gel solution, vitamin C, syrup and Buddhist nun is added in concentrated extracting solution made from the step S1
Golden ethyl ester solution is moored, is uniformly mixed, green blood traditional Chinese medicine oral liquid is made.
6. green blood traditional Chinese medicine oral liquid according to claim 1 treats aplastic anemia, hypoferric anemia, malnutrition in preparation
Application in terms of anaemia, hemolytic anemia, anemia of chronic disease, thrombopenia, oligoleukocythemia disease drug.
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| CN111035700A (en) * | 2020-01-07 | 2020-04-21 | 常州洎夫兰食品有限公司 | Traditional Chinese medicine oral liquid for expelling toxin and beautifying and preparation method thereof |
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Application publication date: 20190416 |