CN1110600A

CN1110600A - Antalgic paster and its preparation method

Info

Publication number: CN1110600A
Application number: CN 95101080
Authority: CN
Inventors: 徐升阳; 昝多安
Original assignee: JIAOZUO SANITARY MATERIAL FACTORY HENAN PROV
Current assignee: JIAOZUO SANITARY MATERIAL FACTORY HENAN PROV
Priority date: 1995-01-17
Filing date: 1995-01-17
Publication date: 1995-10-25
Anticipated expiration: 2015-01-17
Also published as: CN1052418C

Abstract

The Chinese-medicinal plaster as analgesic mainly for treating stasis due to cold type dysmenorrhea and also for curing neck-shoulder pain, lumbago, traumatic pain and stiff neck by attaching it on special acupoint with over 80% effective rate is prepared from 11 Chinese-medicinal materials such as Chinese angelica root, red sage root, white peony root, Chun-xiong rhizome, evodia fruit, etc. Medical adhesive plaster is used as substrate.

Description

Antalgic paster and its preparation method

The present invention belongs to medical plaster agent and the preparation method of being made by the Chinese medicine raw material.

Dysmenorrhes is a kind of common gynaecopathia.According to clinical statistics, the sickness rate of primary dysmenorrhea is 30.4-54.8%, and through domestic 71746 women investigation, serious dysmenorrhea accounts for 13.55%; Moderate pain is through accounting for 38.81%, and therefore actively the control dysmenorrhoea disease is very important to the physical and mental health that shields women.

The medicine for the treatment of at present dysmenorrhea clinically eases pain except that Western medicine sheet, the analgesia pin, and Chinese medicine is used decoction, pill, unguentum, powder, oral medicine etc. more, and the medicine of above-mentioned all dosage forms needs oral administration to go into, thereby it is undesirable to be subjected to the complex effects effect of gastrointestinal and liver.In recent years, through the product of clinical expert and medicine expert joint research " TONGJING TIE " in Guangxi being arranged, is that medicinal liquid is splashed into omphalos (SHENQUE acupoint) the treatment dysmenorrhea that sticks on a piece of adhesive tape again, and this method user is felt inconvenience; The rubber plaster of Shanghai treatment dysmenorrhea mainly is the analgesic based on dispeiling pathogenic wind and removing dampness, and the unable to get up regulating menoxenia.

Purpose of the present invention is exactly at the deficiencies in the prior art part, in conjunction with traditional Chinese medical science traditional theory and modern pharmacological research, provides a kind of both convenient and eutherapeutic antalgic paster, with the physical and mental health that shields women.

The technical solution of the present invention regulating menstruation by adjusting the flow of blood Chinese medicine that nourishes blood of serving as reasons: Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae; Dispelling cold by warming the meridian Chinese medicine: Fructus Evodiae, Cortex Cinnamomi, Herba Asari; Blood-activating analgetic Chinese medicine: Rhizoma Corydalis, Pollen Typhae and the reason liver stomach gas Chinese medicine that stagnates: Rhizoma Cyperi, the Radix Aucklandiae are formed, and make rubber emplastrum, paste cave treatment dysmenorrhoea disease, and its prescription is as follows: (gram)

Radix Angelicae Sinensis 12-18, Radix Paeoniae Alba 10-15, Rhizoma Chuanxiong 10-12, Radix Salviae Miltiorrhizae 12-18, Fructus Evodiae 5-8, Cortex Cinnamomi 5-8, Herba Asari 5-8, Rhizoma Corydalis 10-12, Pollen Typhae 10-12, Rhizoma Cyperi 10-15, Radix Aucklandiae 5-8, Borneolum Syntheticum are an amount of.

Medicine rubber plaster of the present invention is to adopt medical rubber cream cream slurry to be substrate, selects the preparation of high-quality medical material for use, and its matrix formulations is as follows: (kilogram)

Rubber 20-22

Colophonium 20-25

Zinc oxide 25-30

Medical lanoline 2.5-3.5

Medicinal vaseline 5.0-5.5

White oil 0.2

Bobbin oil 0.2

Age resistor 150 grams

Gasoline is an amount of

Technological process of the present invention

One, drug extract preparation:

The ethanol of various picking of raw material, washing, airing → pulverizing → mixing in the prescription → with 90% is soaked molten, temperature is controlled at 60-65 ℃, extracts after 1.5 hours, emit medicinal liquid, again add ethanol in the medicine, extract medicinal liquid three times so repeatedly, three medicinal liquids mix → concentrate → are made fluid extract.

Two, paste manufacture process

Rubber clean → cut glue → oven dry → rubber mixing machine be pressed into strand shape → static 20-26 hour → adding 120# gasoline soaks 20-24 hour → blender and stirred (rotating speed 65-70 rev/min) → add zinc oxide → stirrings 1.5 hours → added Colophonium → 0.5 hour → adding of stirrings lanoline, vaseline, paraffin wax, bobbin oil, age resistor → stirring 2.0 hours → drug extract that adding has made → stirring 2 hours → filter → be coated with cream → dry → cut → close layer → check → packing → finished product.

The existing general plaster of rubber mass of the present invention and drug extract ratio is low, and general plaster ratio is 3.5-4.0: 1.0, and the present invention is 3.0: 1.0; The content of lanoline is 3.5-4.5%, is higher than prior art content 2.5%; Paste containing amount is per 100 square centimeters and is no less than the 1.6-1.7 gram.

The present invention is because in conjunction with traditional Chinese medical science traditional theory and modern pharmacological research, employing regulating menstruation by adjusting the flow of blood, dispelling cold by warming the meridian, blood-activating analgetic and the reason liver stomach gas Chinese medicine that stagnates that nourishes blood is formed, method for making by the state-promulgated pharmacopoeia regulation is made plaster, in 61 the menstrual cycle women of clinical practice in 40 examples, effective percentage reaches more than 80%, no side effects, effect is convenient, and analgesic effect is obvious.

It is raw material that the present invention selects top-quality rubber, superfine zinc oxide, superfine Colophonium, medical anhydrous lanolin for use, make rubber plaster cream slurry, except that having good adhesive performance, zest to skin obviously reduces, improved antiallergic performance to skin, the content height of lanoline in addition, improved the Transdermal absorption effect of medicine, flexibility, the tolerance to cold of plaster have been improved, the present invention is mainly used in menorrhalgia of cold-stagnation and blood-stasis type disease (being particularly useful for the adolescence primary dysmenorrhea), also is applicable to treatment neck and shoulder pain, lumbago, wound pain and stiff neck etc.

Rubber mass of the present invention and drug extract ratio are low, so therapeutic effect is obvious.

The embodiment of the invention:

One, drug extract preparation

With Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Evodiae, Cortex Cinnamomi, Herba Asari, Rhizoma Corydalis, Pollen Typhae, Rhizoma Cyperi, the Radix Aucklandiae is selected respectively, washing, airing is ground into coarse powder with pulverizer, gets Radix Angelicae Sinensis 16 grams, the Radix Paeoniae Alba 13 grams, Rhizoma Chuanxiong 11 grams, Radix Salviae Miltiorrhizae 16 grams, Fructus Evodiae 7 grams, Cortex Cinnamomi 6 grams, Herba Asari 7 grams, Rhizoma Corydalis 11 grams, Pollen Typhae 11 grams, Rhizoma Cyperi 13 grams, the Radix Aucklandiae 7 gram, Borneolum Syntheticum mixes in right amount, soaks with 90% ethanol moltenly to be not less than 24 hours in extraction pot, the consumption of ethanol is with 10 centimetres of degree of being of submergence medicine, temperature is 60 ℃, extracts after 1.5 hours, emits medicinal liquid, again add ethanol in the medicine, extract medicinal liquid three times so repeatedly, three medicinal liquids are mixed, in concentration tank, concentrate, concentration is Baume gravity 1.05, makes fluid extract.

Two, paste manufacture process

Getting rubber washes for 21 kilograms, slitting bulk, dry being lower than under 60 ℃ of temperature, be pressed into the strand shape through rubber mixing machine, placed on the brandreth static 24 hours, add 60 kilograms in 120# gasoline, soaked 22 hours, in 65 rev/mins blender, stirred 30 minutes, add 27 kilograms of superfine zinc oxide, stirred 1.5 hours; Add 23 kilograms of superfine Colophonium, stirred 0.5 hour; Adding is through heat fused good 0.2 kilogram in 0.2 kilogram of 5.0 kilograms of 3.0 kilograms of medical lanolines, medicinal vaselines, white oil, bobbin oil, age resistor (DNP) 150 grams, stirred 2.0 hours, add the drug extract that has made at last, stirred 2 hours, system cream temperature is controlled at below 60 ℃, system cream slurry filters through 120 order copper mesh, after static 8 hours cream is uniformly coated on the bleached cotton fabric, dry being lower than under 60 ℃ of temperature, cut into required specification, close layer with isolating membrane, after the assay was approved, the airtight package warehouse-in.

The acupuncture point that sticks given to this invention is: Shenque, Qihai, cv, (two) come back.

Claims

1, a kind of is substrate composed antalgic paster by Chinese medicine and rubber plaster cream slurry, it is characterized in that:

A: Chinese medicine preparation: (gram)

Radix Angelicae Sinensis 12-18, Radix Paeoniae Alba 10-15, Rhizoma Chuanxiong 10-12, Radix Salviae Miltiorrhizae 12-18,

Fructus Evodiae 5-8, Cortex Cinnamomi 5-8, Herba Asari 5-8, Rhizoma Corydalis 10-12,

Pollen Typhae 10-12, Rhizoma Cyperi 10-15, Radix Aucklandiae 5-8, Borneolum Syntheticum are an amount of;

B: matrix formulations: (kilogram)

Rubber 20-22, Colophonium 20-25,

Zinc oxide 25-30, lanoline 2.5-3.5,

Vaseline 5.0-5.5, white oil 0.2

Bobbin oil 0.2, age resistor 150 grams,

Gasoline is an amount of.

2, the preparation method of antalgic paster according to claim 1 is characterized in that:

A: drug extract preparation

That picking of raw material, washing → airing → pulverizing → mixing → ethanol soak is molten → and extracting medicinal liquid → ethanol soaks moltenly, and extract medicinal liquid → three time medicinal liquids so repeatedly for three times and mix → concentrate → make fluid extract

It is 60-65 ℃ that medicinal liquid extracts temperature;

B: paste manufacture process

Rubber clean → cut glue → oven dry → rubber mixing machine → static 20-26 hour → add gasoline soak 20-24 hour → blender stir 30 minutes → added zinc oxide → stirrings 1.5 hours → added Colophonium → stirrings 0.5 hour → add lanoline, vaseline, paraffin wax, bobbin oil, age resistor → 2 hours → adding of stirring drug extract → 2 hours → filtration of stirring, static → as to be coated with cream → dry → cut → close layer → check → packing → finished product

System cream temperature is no more than 60 ℃.

3, preparation method according to claim 2 is characterized in that:

A: rubber mass and drug extract ratio are 3.0: 1.0;

B: lanoline content is 3.5-4.5%.

4, preparation method according to claim 2 is characterized in that: mainly treat dysmenorrhea, also be applicable to treatment neck and shoulder pain, lumbago, wound pain and stiff neck.