CN1277566C - Method for preparing medicine for treatment of arthralgia-syndrome pain disease - Google Patents

Method for preparing medicine for treatment of arthralgia-syndrome pain disease Download PDF

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CN1277566C
CN1277566C CN 01136639 CN01136639A CN1277566C CN 1277566 C CN1277566 C CN 1277566C CN 01136639 CN01136639 CN 01136639 CN 01136639 A CN01136639 A CN 01136639A CN 1277566 C CN1277566 C CN 1277566C
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medicine
radix
plaster
powder
radix aconiti
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CN1413604A (en
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高大海
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Abstract

The present invention relates to a formula and a preparation method, which belongs to the external use medicine prepared from pure Chinese medicines. More than ten medicines of ephedrae, cassia twig, radix aconiti, kusnezoff monkshood root, angelica, etc. are used for refining an external use medicine bag, medicine plaster and liniment by the special technology. Moreover, the medicine has no toxic or side effect for long term use. Furthermore, the medicine has better effect on preventing and treating diseases of blood stasis and deficient cold, such as rheumatoid arthritis, hyperosteogeny, cervical spondylosis, lumbago and scelalgia, rheumatic heart disease, angina pectoris, coronary disease, chronic hepatitis, chronic nephritis, uremia, asthma, edema, leg turgescence, abdominal distention, vasculitis, dysmenorrhoea, chronic muscle strain, hyperplasia of prostate, nocturia, women postpartum anuresis, etc. The medicine has the advantages of high cure rate, low relapse rate and convenient use, and consequently, patients can gladly accept the medicine.

Description

A kind of preparation method for the treatment of the arthralgia-syndrome pain disease medicine
The invention belongs to the external used medicine that the pure Chinese medicine of a kind of usefulness is made, and relate to its prescription element and manufacture method.
At present, though it is good with oral drugs and muscle, intravascular injection medical treatment disease effects, but still exist many weak points, for example: infect infectious disease because of muscle redness, bacterial infection, intravascular injection due to the injectable drug, and the drug side effectes such as drug induced gastritis that oral drugs cause happen occasionally, in addition, the phenomenon that careless needle body fractures when intramuscular injection is also of common occurrence.For overcoming the deficiency of said method, many medical workers adopt the method for inner disease outer treat, have obtained certain effect, but many external used medicines, because the active ingredient deficiency of medicine, and manufacture method is not good, make the drug penetration difference and do not have the effect of disease preventing and treating.
The objective of the invention is to overcome above-mentioned the deficiencies in the prior art, and provide a kind of with the Chinese medicine natural material, with not the containing hormone, have no side effect of unique technology preparation, safe in utilization, the short treating period of curing the disease, instant effect, to rheumatoid arthritis, hyperosteogeny, lumbago and skelalgia chronic diseases cure rate height, external used medicine that relapse rate is low.
For realizing above-mentioned purpose, the present invention adopts to have pharmacological research and the effective natural Chinese medicinal herb of clinical verification to make, and the weight proportion of Chinese herbal medicine is:
Herba Ephedrae 1g Ramulus Cinnamomi 1g Radix Aconiti Preparata 2g Radix Aconiti Kusnezoffii Preparata 2g Radix Angelicae Sinensis 2g Rhizoma Arisaematis 0.8g
Semen Persicae 1g Flos Carthami 1.2g Cortex Phellodendri 1g Radix Et Rhizoma Rhei 2g Radix Angelicae Pubescentis 1.2g breast does not have each 1g
Borneolum Syntheticum 0.03g Camphora 0.02g
Weight proportion expansion deal by above-mentioned each crude drug is made externally used medicine bag, plaster, the different classes of medicine external preparation of liniment.
The present invention is further illustrated with regard to specific embodiment below.The embodiment of the invention one: earlier with Herba Ephedrae, Ramulus Cinnamomi, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Angelicae Pubescentis medical material is put and is dried in the sun, and removes impurity contained in the medicine and mould matter product, and the requirement of processing by medicine physics and chemistry big gun cleans big gun and processs oven dry.Every kind of medicine after the oven dry enlarges content ratio in the prescription element according to the number of volume of production, with pulverizer medicine is pulverized to mix and stirs the back and cross 80-100 mesh sieve patent medicine powder.In addition, again Camphora, Borneolum Syntheticum are enlarged each components contents ratio in its prescription in volume of production, cross 80-100 mesh sieve powdered with the metal trough grind up, at last Borneolum Syntheticum, camphor powder are mixed mutually with other Chinese medicine powder and mix thoroughly, weigh up medicated powder 15-30g, or weigh up medicated powder by actual requirement, and pack into and a kind ofly make in the deck made from cotton and other material, then deck is reinstalled a kind of strip sheath band the inside made from cloth.During use the sheath band is fixed on body surface position or acupuncture point, reaches the purpose of disease preventing and treating by the osmosis of medicine.
The profile of medicinal bag and medicine sheath band, or size and color can design and produce according to actual needs.The making material of medicated bag and sheath band is that textile fabric or the fabric that does not have Chemical fiber component all can.
The embodiment of the invention two, processing and fabricating externally applied ointment of the present invention, the method for processing plaster is divided into two kinds.First method is: take by weighing Oleum sesami and put into pot, heating is endured out, with Herba Ephedrae, Ramulus Cinnamomi, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Angelicae Sinensis, Rhizoma Arisaematis, Semen Persicae, Flos Carthami, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Angelicae Pubescentis is mixed thoroughly after assorting by the content exaggerated scale of every herbal medicine in the above-mentioned prescription composition according to processing capacity, drop in the oil cauldron (Oleum sesami want height take the dish out of the pot inside medicine face 3~5cm, medicine all is immersed in the oil), continue heating and tempered 2 hours, make the temperature in the oil cauldron be controlled at 280~300 ℃, refine to fluid and splash into Cheng Zhu in the water, that blows does not loose, can stop heating, when temperature is reduced to 260 ℃, plaster raw material Plumbum preparatium (in right amount) the limit edged of crossing 80~100 mesh sieves be stirred, spray into a little cold water and remove cigarette until adding, when treating that temperature is reduced to 70 ℃, the Borneolum Syntheticum of 100 mesh sieves will be pulverized, Camphora, breast does not have powder (ratio according to each medicine in the prescription composition is assorted by volume of production) to add, and stirs, add the cold water submergence again, soak 24~48h, releasing fire-toxin takes out then, thermoplastic, the stand is applied to mount and promptly gets externally applied ointment of the present invention on the backing material.With the thermoplastic of plaster tepor, be affixed on acupuncture point and affected part during use.Reach the purpose of preventing and curing diseases by the drug osmotic effect.Plaster mount the available kraft paper of backing material, cloth and permeability material preferably.The big I of the face shaping of plaster designs and produces according to actual needs.
The 2nd kind of processing plaster method of embodiment two is:
First with Herba Ephedrae, Ramulus Cinnamomi, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Angelicae Pubescentis, Rhizoma Arisaematis are by the processing of medical material requirement, and screening is dried, according to various content of medicines ratios in the above-mentioned prescription composition, after enlarging deal and take by weighing respectively by the number of producing, mix is ground into fine powder together, and is moistening with 90% ethanol, put into percolator, the shop is even to flatten, and top raggle block gauze is put into 90% ethanol liquid then and exceeded medicinal powder face 15~20cm, soak 24h, the beginning percolation, flow velocity is 150ml/mim, collects percolate.Percolate reclaims ethanol, and it is standby to be concentrated into the thick paste shape.By the content ratio in the above-mentioned prescription composition, after the deal that enlarges medicine according to production quantity takes by weighing, pulverize mix homogeneously and cross 100 mesh sieves standby the Olibanum Myrrha.In addition Camphora, Borneolum Syntheticum are enlarged deal by volume of production and take by weighing, use 95% dissolve with ethanol, standby.Take by weighing plaster raw material raw rubber (by the amount of total dose 50%) and be cut into strip, clean oven dry, be pressed into the thick thin slice of 2~3mm then, place 24 hours standby.Take by weighing Colophonium (by the amount of total dose 50%), gasoline (by the amount of total dose 70%), then the sheet rubber and the Colophonium that press are put into agitator, add whole gasoline, stir 30min and leave standstill 24h, restir 2h, add wintergreen oil 20 grams, lanoline 100 grams, vaseline 50 grams, zinc oxide (by the amount of total dose 70%), breast do not have the alcoholic solution of powder, Camphora and Borneolum Syntheticum, and, continue to stir more than 6 hours, with 80 mesh sieve filter pressings with the spissated Chinese medicine thick paste of ethanol percolation, filtrate is left standstill a week, can spread out to be coated with.
When the stand was coated with, with the pastille rubber cement, the stand was applied on the glue spreader, and by 80~90 ℃ of temperature in Drying tunnel drying, the Drying tunnel, the Drying tunnel rear part temperature can hang down, and then, the medicine adhesive plaster volume that coats was cut into 5 * 7cm 2Or suitably big or small specification, conform to the plastics pharmaceutical film again and promptly get externally applied ointment of the present invention.During use, tear softening affected part and the acupuncture point of being affixed on of plastic foil on the plaster or tepor off, the osmosis by medicine reaches the disease preventing and treating purpose.
The embodiment of the invention three: the method for processing and fabricating liniment of the present invention is first with Herba Ephedrae, Ramulus Cinnamomi, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Angelicae Pubescentis, Rhizoma Arisaematis, the requirement that breast is not processed by medicine physics and chemistry big gun cleans big gun and processs, then, according to production and processing amount size, connect various content of medicines expansion drug ratios in the above-mentioned prescription composition.Take by weighing to mix thoroughly and add in the 70% ethanol liquid, (ethanol exceeds medical material face 10~15cm, medical material all is immersed in the ethanol), soaked 20 days, incline alcoholic solution after, add 70% ethanol liquid again and soaked 20 days, inclining the immersion alcoholic solution again, this moment, the leachate with twice merged, filter with 100 mesh sieves, camphorate in the filtrate, 2 kinds of medicines of Borneolum Syntheticum stir evenly and soak after 20 days, can become externally-applied liniment of the present invention, bottle or container with different size carry out coating-dividing sealing, open bottle cap during use, are stained with this medicinal liquid with Cotton Gossypii, be coated with and put on the skin, reach the purpose of disease preventing and treating by the osmosis of medicine at human body certain acupuncture point or diseased region.
The present invention is except that above-mentioned processing technology technology, also can be according to the present invention various medicament contgs in the prescription element of medicine, according to the Pharmacopoeia of the People's Republic of China and " external medicine preparation of the present invention of multiple different dosage form, different size is produced in pharmaceutical preparation handbook processing preparation.
The present invention shows through pharmacological research, have effects such as warm muscle pain relieving, warming the interior cold expelling, recuperating depleted YANG and rescuing the patient from collapse, heart tonifying diuresis, blood circulation promoting and blood stasis dispelling, function of gallbladder promoting relieving constipation, the detumescence of reducing phlegm, can improve blood circulation, coronary blood flow increasing, anticoagulation, blood fat reducing, blood viscosity cholesterol, improve the immunity of body, control heart stricture of vagina pain, apoplectic hemiplegia, diabetes, coronary heart disease, rheumatoid arthritis, rheumatic heart disease, lumbago and skelalgia, edema, stomachache etc. have effect preferably.
Medicated bag of the present invention, plaster, liniment have warm muscle pain relieving, blood circulation promoting and blood stasis dispelling through clinical thousands of patients' observation, Yin Yang balancing, regulate the function of QI and blood.But reducing swelling and alleviating pain, anticoagulation, improve blood circulation, reduce blood viscosity, blood glucose, blood fat and cholesterol, coronary blood flow increasing, heart tonifying diuresis, make the blood vessel of obstruction can be unimpeded rapidly, the very fast elimination of nuisance mass-energy in the body.Can in 30 minutes, take effect to treatment of diseases, effective percentage 98.6%, and have no side effect.Biggest advantage of the present invention is to make with pure natural medical, does not contain hormone, to the side effect that the stingless sentiment of skin is dyed, and short treating period, instant effect, the cure rate height, relapse rate is low, and is easy to use, and the patient takes like a shot.
, blood fat swollen to rheumatoid arthritis, chronic muscular strain, chronic hepatitis, abdominal distention, heart stricture of vagina pain, coronary heart disease, rheumatic heart disease, cyclomastopathy, apoplectic hemiplegia, vasculitis, asthma, chronic nephritis, uremia, edema, hyperosteogeny, cervical spondylosis, lumbago and skelalgia, lower limb increases disease, diabetes, puerperal urine retention, stimulates the menstrual flow, prostatic hyperplasia, nocturia, the not homoiothermy stasis of blood deficiency and coldness disease of lower limb of suffering from a deficiency of the kidney, and has unique prevention effect.

Claims (2)

1. Chinese medicine external used medicine for the treatment of arthralgia-syndrome pain disease, it is characterized in that: the weight proportion of crude drug is:
Herba Ephedrae 1g Radix Aconiti Preparata 2g Radix Aconiti Kusnezoffii Preparata 2g Ramulus Cinnamomi 1g Radix Angelicae Sinensis 2g Semen Persicae 1g Flos Carthami 1.2g
Cortex Phellodendri 1g Radix Angelicae Pubescentis 1.2g Rhizoma Arisaematis 0.8g Radix Et Rhizoma Rhei 2g breast does not have each 1g Borneolum Syntheticum 0.03g Camphora 0.02g
Weight proportion expansion deal by the above-mentioned raw materials medicine is made externally used medicine bag, plaster, the different classes of external used medicine of liniment.
2. the external used medicine of a kind of treatment arthralgia-syndrome pain disease made from Chinese medicine according to claim 1 is characterized in that its preparation method is one of following method:
2.1. make the preparation method of externally used medicine bag:
2.1.1. with each medical herbs respectively by the requirement that the medicine big gun is processed clean, big gun is processed, dry pulverizing, press the content ratio batching in the prescription composition again, cross 80~100 mesh sieve patent medicine powder, at last Borneolum Syntheticum, camphor powder are mixed mutually with other Chinese medicine powder and mix thoroughly, weigh up medicated powder 15~30g, or weigh up medicated powder, pack into and a kind ofly make in the deck made from the cotton material by the required amount of reality, then deck is reinstalled in a kind of strip sheath band made from cloth, promptly get externally used medicine bag of the present invention;
2.2. make first kind of preparation method of plaster:
2.2.1. Oleum sesami is put into pot, and heating is endured out, with Herba Ephedrae, and Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Ramulus Cinnamomi, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Cortex Phellodendri, Radix Angelicae Pubescentis, Rhizoma Arisaematis, Radix Et Rhizoma Rhei are assorted in the desired amount and are mixed thoroughly, drop into to temper in the oil cauldron to fluid to splash into Cheng Zhu in the water, that blows does not loose, and stops heating, after temperature is reduced to 260 ℃, 80~100 mesh sieve plaster raw material Plumbum preparatiums of pulverizing are added the pot the inside, and the limit edged stirs, up to adding; Spray into a little cold water and remove cigarette, when treating that temperature drops to 70 ℃, with the Borneolum Syntheticum of 100 mesh sieves pulverized, Camphora, breast do not have powder to add, and stir, and add cold water soak 24~48h again, take out thermoplastic then, and the stand is applied to mounts on the backing material, promptly gets plaster of the present invention;
2.3. make second kind of preparation method of plaster:
2.3.1. with Herba Ephedrae, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Ramulus Cinnamomi, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Cortex Phellodendri, Radix Angelicae Pubescentis, Rhizoma Arisaematis, the Radix Et Rhizoma Rhei big gun is processed oven dry and is ground into fine powder, and the medicated powder of pulverizing is moistening with 90% ethanol, puts into percolator, gauze on the even dress cover in shop, put into 90% ethanol liquid and soak 24h, collect percolate, and be concentrated into the thick paste shape, with Olibanum, Myrrha was pulverized 100 mesh sieves, with Camphora, and Borneolum Syntheticum 95% dissolve with ethanol, take by weighing plaster raw material raw rubber by the amount of total dose 50% and be cut into strip and clean oven dry, be pressed into 2~3 thick thin rubber sheets; Place 24 hours standby, take by weighing the gasoline of Colophonium and 70% by the amount of total dose 50%, sheet rubber that presses and Colophonium are put into agitator, add whole gasoline, stirred 30 minutes, left standstill 24 hours, restir 2 hours adds wintergreen oil 20 grams, lanoline 100 grams, vaseline 50 grams, zinc oxide is by the amount of total dose 70%, and breast does not have powder, the alcoholic solution of Camphora and Borneolum Syntheticum, and with the spissated Chinese medicinal ointment of ethanol percolation, continue to stir more than 6 hours, filter with 80 mesh sieves, filtrate is left standstill a week, can spread out and be coated with, the medicine adhesive plaster volume that coats is cut into size specification, conform to the plastics pharmaceutical film again and promptly get external cream of the present invention;
2.4. make the method for externally-applied liniment:
2.4.1. with Herba Ephedrae, Ramulus Cinnamomi, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata,, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Angelicae Pubescentis, Rhizoma Arisaematis, breast does not have, and the requirement of processing by medicine physics and chemistry big gun cleans big gun and processs, and adds in the 70% ethanol liquid and soaks 20 days, and inclining alcoholic solution, added 70% soak with ethanol again 20 days, inclining alcoholic solution again, and twice leachate that inclines merged, filter with 100 mesh sieves, camphorate in the filtrate and Borneolum Syntheticum stirs evenly and soaked 20 days, promptly get externally-applied liniment of the present invention.
CN 01136639 2001-10-24 2001-10-24 Method for preparing medicine for treatment of arthralgia-syndrome pain disease Expired - Fee Related CN1277566C (en)

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101612220B (en) * 2009-07-21 2011-05-11 杭州市中医院 External-application cream for treating osteoarthritis and preparation method thereof
CN101703646B (en) * 2009-11-26 2011-05-25 黄远吉 Externally applied Chinese medicine composition for treating hyperosteogeny
CN103239542B (en) * 2013-05-10 2015-03-11 云南省中医医院 Medicament for treating gouty arthritis prepared from traditional Chinese medicines and preparation method thereof
CN105362535A (en) * 2014-08-08 2016-03-02 吴奇 Rheumatalgia treating wet ointment
CN108379490A (en) * 2018-05-16 2018-08-10 山东普林生物科技有限公司 A kind of quick conditioning and treating women palace cold, dysmenorrhoea, cold body, trick ice-cold nanometer and small molecule Chinese medicine bath foam
CN108403874A (en) * 2018-05-16 2018-08-17 陈朗 A kind of vigor moisturizing mud and preparation method thereof
CN111514238A (en) * 2019-02-01 2020-08-11 曲振宇 Externally-applied ointment for treating rheumatism and preparation method thereof
CN111214598A (en) * 2020-01-23 2020-06-02 黎帝明 A Chinese medicinal composition for treating rigidity of muscles and activating collaterals, traumatic injury and sprain, and rheumatalgia
CN113855752A (en) * 2021-11-11 2021-12-31 彭海 A Chinese medicinal composition for treating osteoarticular diseases, and its preparation method

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