CN107456484A - It is a kind of to be used to prevent and treat external plaster of coronary heart disease and preparation method thereof - Google Patents
It is a kind of to be used to prevent and treat external plaster of coronary heart disease and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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Abstract
The invention belongs to emplastrum and its preparing technical field.The invention discloses a kind of external plaster for being used to prevent and treat coronary heart disease and preparation method thereof, the emplastrum is made by raw materials such as the red sage root, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, myrrh, cloves, frankincense, dalbergia wood, camphor, musk xylene, menthol, bagodryl hydrochloride, borneol, rubber, rosin, zinc oxide, vaseline, chitosan, dimethylaminoethyl methacrylate methacrylate copolymer and gasoline, and its preparation method is made up of stock, pharmacy, refining glue, cladding, mashing, gluing, drying and post-treating and other steps.It is used to prevent and treat effect of the external plaster of coronary heart disease with good prevention and treatment coronary heart disease in the present invention；With good gas permeability, there is good slow release effect, drug effect time length；The preparation method of external plaster in the present invention for preventing and treating coronary heart disease is simple, easily realizes on existing.
Description
Technical field
The present invention relates to emplastrum and its preparing technical field, is used to prevent and treat the outer of coronary heart disease more particularly, to a kind of
With emplastrum and preparation method thereof.
Background technology
Coronary heart diseases and angina pectoris is the illness occurred frequently in clinic, and the incidence of disease of the illness is in the trend increased year by year, and its is serious
Endanger the health of the mankind.Existing ointment for treating coronary disease is tight using natural rubber matrix, the emplastrum one of natural rubber matrix
The shortcomings that weight is exactly its gas permeability extreme difference, even if can be punched in the prior art on emplastrum lining cloth to improve the saturating of emplastrum
Gas, but because to improve the gas permeability of emplastrum lotion, such improvement, effect is extremely limited, it is difficult to realize good saturating
The requirement of gas.In addition, it is also the problem of existing natural rubber matrix emplastrum is present also to have one disadvantage in that, when that is to say its drug effect
Between it is short, the characteristics of without long-acting action, this, which has also resulted in patient, needs often to change emplastrum when in use, this to patient with
Great inconvenience is carried out, especially for this emplastrum for needing to stick on privileged sites of ointment for treating coronary disease, it is even more to bring greatly to change
Inconvenience；Existing slow releasing pharmaceutical exists only in the medicine of the class such as oral, and for topical class medicine, the method for being sustained processing does not almost have
Have, can be to realize feasible effective medicament slow release processing method.
The content of the invention
To solve the above problems, the invention provides a kind of good permeability to be not susceptible to allergic reaction, while also have suitable
The external plaster for being used to prevent and treat coronary heart disease for medicament slow release effect of external application；
The above-mentioned preparation method for being used to prevent and treat the external plaster of coronary heart disease is prepared present invention also offers a kind of.
To achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of external plaster for being used to prevent and treat coronary heart disease, is mainly made by the raw material of following parts by weight：
100 parts of the red sage root, 90~110 parts of Ligusticum wallichii, 95~110 parts of Radix Angelicae Sinensis, 40~55 parts of safflower, 35~40 parts of myrrh, cloves 37~
38 parts, 36~38 parts of frankincense, 37~38 parts of dalbergia wood, 22~26 parts of camphor, 10~14 parts of musk xylene, menthol 22~27
Part, 4~6 parts of bagodryl hydrochloride, 45~60 parts of borneol, 400~500 parts of rubber, 350~400 parts of rosin, zinc oxide 420~
480 parts, 40~50 parts of vaseline, 5~10 parts of chitosan, dimethylaminoethyl methacrylate-methacrylate
8~12 parts of copolymer, 900~1200 parts of solvent.
Preferably, mainly it is made for the external plaster for preventing and treating coronary heart disease by the raw material of following parts by weight：
100 parts of the red sage root, 100 parts of Ligusticum wallichii, 100 parts of Radix Angelicae Sinensis, 50 parts of safflower, 37.5 parts of myrrh, 37.5 parts of cloves, 37.5 parts of frankincense,
37.5 parts of dalbergia wood, 25 parts of camphor, 12.5 parts of musk xylene, 25 parts of menthol, 5 parts of bagodryl hydrochloride, 50 parts of borneol, rubber
445 parts, 368 parts of rosin, 445 parts of zinc oxide, 43 parts of vaseline, 8 parts of chitosan, dimethylaminoethyl second
10 parts of ester-methacrylate copolymer, 1000 parts of solvent.
Dimethylaminoethyl methacrylate-methacrylate copolymer is a kind of high-molecular copolymer, and it is in neutrality
Or it can be stabilized in alkaline environment without destroyed, but in weakly acidic condition, its corrosion that be able to can be decomposed；Deacetylated first
Shell element is chitosan, and untreated chitosan is a kind of organic polymer for being insoluble in water, is also had shell in the prior art
Application of the glycan as medicinal slow release agent, generally as oral drugs controlled-release agent application, what it was mainly utilized is internal molten for it
The effect of bacterium enzyme, in the presence of lysozyme, chitosan is slowly decomposed in order, concurrent so as to discharge effective ingredient
Wave drug effect；But in emplastrum field, because the compositions such as lysozyme are not present in outer surface of the skin, it is difficult to decompose chitosan, therefore
It can not also be applied.Sweat is that it mainly contains the materials such as lactic acid uric acid by a kind of material of sweat gland secretion in skin, is presented
Faintly acid；Although chitosan can not be dissolved in the water of neutrality, it is their ability to occur in weak acid environment a certain degree of
Dissolving, therefore to using chitosan as sustained release agent be applied in emplastrum, then need to provide enough weak acid environments, Ye Jixu
To promote the secretion of skin surface sweat to a certain extent, certain weak acid ring is presented in the skin surface where enabling emplastrum
Border, and a few herbs such as safflower, Radix Angelicae Sinensis and red sage root all have promoting blood circulation, stagnation resolvation and other effects in inventive formulation, can promote to stick
Locate skin perspiration, at the place of sticking and its to be formed about a sweat more abundant and weakly acidic environment is presented, in this environment, first
Base dimethylaminoethyl acrylate-methacrylate copolymer can be destroyed slowly, and chitosan also can be gradually
Gradually be dissolved, so as to play a part of medicament slow release.
Preferably, solvent is gasoline.
Preferably, zinc oxide is the weight of the mixture, wherein zinc oxide fiber of Zinc oxide powder and zinc oxide fiber
Percentage is 35~40wt%, and surplus is Zinc oxide powder；The length of zinc oxide fiber is 0.1~1mm, and draw ratio is 5~10.
Preferably, through steps of processing before zinc oxide use：
Zinc oxide is added in the water of 2~5 times of zinc oxide weight, the carboxymethyl for then adding zinc oxide weight 20~35% is fine
Dimension element, and with 41~50rpm rotating speed magnetic agitation 10~15 minutes, afterwards with 11~15rpm rotating speed magnetic agitation 1~3
After minute, liquid is removed using vacuum freeze drying；When wherein vacuum freeze drying is handled, temperature is -20~-15 DEG C, vacuum
Spend for 1.3~10Pa.
Zinc oxide in the present invention is to not change master by the way of Zinc oxide powder and zinc oxide fiber mixing
On the premise of medicine composition, the requirement for improving emplastrum gas permeability is realized.From length-specific and the zinc oxide fiber of draw ratio, by this
A kind of stereochemical structure of rack-like can be presented after a little zinc oxide fiber processing, there can be numerous hole knots in its structure
Structure, the gas permeability of emplastrum is improved using the hole in these zinc oxide fiber rack-like structures, and the solution of the present invention is based on this structure
Think.Experiment proves that zinc oxide fiber of the length in the range of 0.1~1mm is relatively easy to disperse, while is added to when being used in emplastrum
Also the sensation of difference will not be produced, and selects zinc oxide fiber of the draw ratio in the range of 5~10 to be easier to form rack-like solid
Structure, while the hole formed also has more stability.In order to realize this rack-like structure zinc oxide collection with pore space structure
Zinc oxide fiber, it is necessary to first be distributed in solution by zoarium, and water is most suitable decentralized medium, in view of the surface due to zinc oxide
Characteristic can promote the scattered of zinc oxide after ethanol is properly added, while appropriate addition ethanol can also make in subsequent step more
Fast removing solvent, but because ethanol is combustible material, danger when excessive ethanol can also increase dry, based on above-mentioned
The percentage by weight of reason ethanol disclosure satisfy that above-mentioned condition at 10% or so and risk can be reduced into minimum.From magnetic force
The reason for stirring, is, because follow-up freeze-drying needs to carry out to guarantee to obtain optimal rack-like knot while stirring
Structure, and magnetic agitation is carried out in the case of being not directly contacted with agitating device and solution, is difficult to when avoiding using agitator same
The problem of Shi Jinhang is dried in vacuo, only have magneton to be located in dispersion liquid during using magnetic agitation, will not shadow during vacuum freeze drying
Ring drying process；The quick stirring of early stage, the zinc oxide fiber in disperseing can be made quickly to form structure, follow-up mixes slowly
Stability Analysis of Structures can be present.And Zinc oxide powder, particle diameter can be selected in 200~300 mesh powders, in view of zinc oxide fiber
The selection of size, the Zinc oxide powder in this particle size range will not enter in the hole of rack-like structure, be unlikely to block ventilative
Duct；In processing, Zinc oxide powder is also together added zinc oxide fiber, while is handled, and small dynamics can be carried out after processing
Crushing.
A kind of preparation method for being used to prevent and treat the external plaster of coronary heart disease, comprises the following steps：
a）Stock：Stocked up by above-mentioned formula；
b）Pharmacy：The red sage root, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, myrrh, cloves, frankincense, dalbergia wood are ground into coarse powder, then added into coarse powder
The ethanol that the concentration of 0.6~0.7 times of overstriking powder weight is 90vol% stands 30~45 minutes, is then transferred in percolator, and
The ethanol for adding concentration to be 90vol% makes liquid level be higher by 3~5cm of material, and dipping was 3~5mL/ by diacolation speed after 45~50 hours
Min collects percolate, and finally by percolate at 45~55 DEG C, steam pressure is not more than 0.01Mpa, and vacuum 0.06~
Concentrated under 0.08MPa and liquid extract is made；
c）Refining glue：Rubber is cut into the wide strips of 10~20cm, is put into afterwards in rubber mixing machine and rolls refining, is made and rolls refining rubber；
d）Cladding：By chitosan and dimethylaminoethyl methacrylate-methacrylate copolymer mix and to
Wherein add the absolute ethyl alcohol of both 50~60 times of weight and dissolving is obtained up to being completely dissolved at 50~70 DEG C, be subsequently added into
Liquid extract, and be stirred continuously 30~40 minutes, liquid extract cladding material is made；
e）Mashing：Refining rubber will be rolled with being standing and soak for 22~26 hours in solvent input mixer, first put into camphor, two thereto
Trinitro-tert-butyl-toluene, menthol, bagodryl hydrochloride and borneol simultaneously stir 30~40 minutes, then put into rosin, vaseline thereto
Stirring 3~4 hours, put into after then mixing zinc oxide and liquid extract cladding material, stirring 1~2 hour, and with 4500~5000
Rubber cement is made after the filtering of mesh bolting silk；
d）Gluing：Obtained rubber cement is coated on elastical cloth, and it is 0.3~0.5mg/cm to control paste containing amount2；
e）Drying：The elastical cloth for having coated rubber cement carries out drying and processing, the temperature of three baking zones by three baking zones successively
It is followed successively by 55~65 DEG C, 85~95 DEG C, 65~75 DEG C；
f）Post processing：The product of above-mentioned steps processing is cut, lining form, section and packing processes.
In the present invention, the material for coating medicine, i.e. chitosan and dimethylaminoethyl are added
The amount of ethyl ester-methacrylate copolymer can only well coat 70~80% or so medicine, remaining after so being coated
20~30% drug ingedient not being wrapped by can work immediately after sticking, and without when covering coating film slowly by
Just worked after destruction so that drug effect of the present invention more can also have more continuity in time.
Preferably, in step b, coarse powder particle diameter is less than 24 mesh, and is no more than 40wt% less than 65 purposes.
Preferably, the relative density of obtained liquid extract is 1.05 in step b.
Preferably, in step e, roll before refining rubber is standing and soak for solvent and stirred 2 minutes every 3 hours, stir 2 altogether
It is secondary.
Therefore, the invention has the advantages that：
（1）It is used to prevent and treat effect of the external plaster of coronary heart disease with good prevention and treatment coronary heart disease in the present invention
Fruit；
（2）The external plaster for being used to prevent and treat coronary heart disease in the present invention has good gas permeability, has good sustained release
Effect, drug effect time length；
（3）The preparation method of external plaster in the present invention for preventing and treating coronary heart disease is simple, easily on existing
Realize.
Embodiment
Technical scheme is further described with reference to embodiment.
Obviously, described embodiment is only the part of the embodiment of the present invention, rather than whole embodiments.Based on this
Embodiment in invention, all other reality that those of ordinary skill in the art are obtained under the premise of creative work is not made
Example is applied, belongs to the scope of protection of the invention.
Embodiment 1
A kind of external plaster for being used to prevent and treat coronary heart disease, is mainly made by the raw material of following parts by weight：
100 parts of the red sage root, 90 parts of Ligusticum wallichii, 95 parts of Radix Angelicae Sinensis, 40 parts of safflower, 35 parts of myrrh, 37 parts of cloves, 36 parts of frankincense, 37 parts of dalbergia wood,
22 parts of camphor, 10 parts of musk xylene, 22 parts of menthol, 4 parts of bagodryl hydrochloride, 45 parts of borneol, 400 parts of rubber, rosin 350
Part, 420 parts of zinc oxide, 40 parts of vaseline, 5 parts of chitosan, dimethylaminoethyl methacrylate-methacrylate
8 parts of copolymer, 900 parts of gasoline；
Wherein, zinc oxide is the mixture of Zinc oxide powder and zinc oxide fiber, and the percentage by weight of wherein zinc oxide fiber is
35wt%, Zinc oxide powder 65wt%；The length of zinc oxide fiber is 0.1mm, draw ratio 5；
Zinc oxide uses preceding through steps of processing：Zinc oxide is added in the water of 2 times of zinc oxide weight, then adds oxidation
The carboxymethyl cellulose of zinc weight 20%, and with 41rpm rotating speed magnetic agitation 10 minutes, stirred afterwards with 11rpm rotating speed magnetic force
After mixing 1 minute, liquid is removed using vacuum freeze drying；When wherein vacuum freeze drying is handled, temperature is -20 DEG C, vacuum
For 1.3Pa.
A kind of preparation method for being used to prevent and treat the external plaster of coronary heart disease, comprises the following steps：
a）Stock：Stocked up by above-mentioned formula；
b）Pharmacy：The red sage root, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, myrrh, cloves, frankincense, dalbergia wood are ground into coarse powder, coarse powder particle diameter is less than 24
Mesh, and it is no more than 40wt% less than 65 purposes, the concentration that 0.6 times of coarse powder weight is then added into coarse powder is 90vol% second
Alcohol stands 30 minutes, is then transferred in percolator, and the ethanol for adding concentration to be 90vol% makes liquid level be higher by material 3cm, impregnates
Percolate is collected for 3mL/min by diacolation speed after 45 hours, finally by percolate at 45 DEG C, steam pressure is not more than
Concentrated under 0.01Mpa, vacuum 0.06MPa and liquid extract is made；The relative density of obtained liquid extract is 1.05；
c）Refining glue：Rubber is cut into the wide strips of 10cm, is put into afterwards in rubber mixing machine and rolls refining, is made and rolls refining rubber；
d）Cladding：By chitosan and dimethylaminoethyl methacrylate-methacrylate copolymer mix and to
Wherein add the absolute ethyl alcohol of both 50 times of weight and dissolving be obtained up to being completely dissolved at 50 DEG C, be subsequently added into liquid extract,
And be stirred continuously 30 minutes, liquid extract cladding material is made；
e）Mashing：Refining rubber will be rolled with solvent input mixer, stirring every 3 hours 2 minutes, stirring 2 times altogether, it is then quiet
Immersion 22 hours is put, first puts into camphor, musk xylene, menthol, bagodryl hydrochloride and borneol and 30 points of stirring thereto
Clock, rosin, vaseline stirring 3 hours is then put into thereto, put into, stir after then zinc oxide is mixed with liquid extract cladding material
Mix 1 hour, and rubber cement is made after being filtered with 4500 mesh bolting silks；
d）Gluing：Obtained rubber cement is coated on elastical cloth, and it is 0.3mg/cm to control paste containing amount2；
e）Drying：The elastical cloth for having coated rubber cement carries out drying and processing, the temperature of three baking zones by three baking zones successively
It is followed successively by 55 DEG C, 85 DEG C, 65 DEG C；
f）Post processing：The product of above-mentioned steps processing is cut, lining form, section and packing processes.
Embodiment 2
A kind of external plaster for being used to prevent and treat coronary heart disease, is mainly made by the raw material of following parts by weight：
100 parts of the red sage root, 100 parts of Ligusticum wallichii, 100 parts of Radix Angelicae Sinensis, 50 parts of safflower, 37.5 parts of myrrh, 37.5 parts of cloves, 37.5 parts of frankincense,
37.5 parts of dalbergia wood, 25 parts of camphor, 12.5 parts of musk xylene, 25 parts of menthol, 5 parts of bagodryl hydrochloride, 50 parts of borneol, rubber
445 parts, 368 parts of rosin, 445 parts of zinc oxide, 43 parts of vaseline, 8 parts of chitosan, dimethylaminoethyl second
10 parts of ester-methacrylate copolymer, 1000 parts of gasoline；
Wherein, zinc oxide is the mixture of Zinc oxide powder and zinc oxide fiber, and the percentage by weight of wherein zinc oxide fiber is
37wt%, Zinc oxide powder 63wt%；The length of zinc oxide fiber is 0.5mm, draw ratio 7；
Zinc oxide uses preceding through steps of processing：Zinc oxide is added in the water of 4 times of zinc oxide weight, then adds oxidation
The carboxymethyl cellulose of zinc weight 28%, and with 45rpm rotating speed magnetic agitation 12 minutes, stirred afterwards with 13rpm rotating speed magnetic force
After mixing 2 minutes, liquid is removed using vacuum freeze drying；When wherein vacuum freeze drying is handled, temperature is -17 DEG C, vacuum
For 5Pa.
A kind of preparation method for being used to prevent and treat the external plaster of coronary heart disease, comprises the following steps：
a）Stock：Stocked up by above-mentioned formula；
b）Pharmacy：The red sage root, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, myrrh, cloves, frankincense, dalbergia wood are ground into coarse powder, coarse powder particle diameter is less than 24
Mesh, and it is no more than 40wt% less than 65 purposes, the concentration that 0.65 times of coarse powder weight is then added into coarse powder is 90vol% second
Alcohol stands 38 minutes, is then transferred in percolator, and the ethanol for adding concentration to be 90vol% makes liquid level be higher by material 4cm, impregnates
Percolate is collected for 4mL/min by diacolation speed after 47 hours, finally by percolate at 50 DEG C, steam pressure is not more than
Concentrated under 0.01Mpa, vacuum 0.07MPa and liquid extract is made；The relative density of obtained liquid extract is 1.05；
c）Refining glue：Rubber is cut into the wide strips of 15cm, is put into afterwards in rubber mixing machine and rolls refining, is made and rolls refining rubber；
d）Cladding：By chitosan and dimethylaminoethyl methacrylate-methacrylate copolymer mix and to
Wherein add the absolute ethyl alcohol of both 55 times of weight and dissolving be obtained up to being completely dissolved at 60 DEG C, be subsequently added into liquid extract,
And be stirred continuously 35 minutes, liquid extract cladding material is made；
e）Mashing：Refining rubber will be rolled with solvent input mixer, stirring every 3 hours 2 minutes, stirring 2 times altogether, it is then quiet
Immersion 24 hours is put, first puts into camphor, musk xylene, menthol, bagodryl hydrochloride and borneol and 35 points of stirring thereto
Clock, rosin, vaseline stirring 3.5 hours is then put into thereto, put into after then zinc oxide is mixed with liquid extract cladding material,
Stirring 1.5 hours, and rubber cement is made after being filtered with 4800 mesh bolting silks；
d）Gluing：Obtained rubber cement is coated on elastical cloth, and it is 0.4mg/cm to control paste containing amount2；
e）Drying：The elastical cloth for having coated rubber cement carries out drying and processing, the temperature of three baking zones by three baking zones successively
It is followed successively by 60 DEG C, 90 DEG C, 70 DEG C；
f）Post processing：The product of above-mentioned steps processing is cut, lining form, section and packing processes.
Embodiment 3
A kind of external plaster for being used to prevent and treat coronary heart disease, is mainly made by the raw material of following parts by weight：
100 parts of the red sage root, 110 parts of Ligusticum wallichii, 110 parts of Radix Angelicae Sinensis, 55 parts of safflower, 40 parts of myrrh, 38 parts of cloves, 38 parts of frankincense, dalbergia wood 38
Part, 26 parts of camphor, 14 parts of musk xylene, 27 parts of menthol, 6 parts of bagodryl hydrochloride, 60 parts of borneol, 500 parts of rubber, rosin
400 parts, 80 parts of zinc oxide, 50 parts of vaseline, 10 parts of chitosan, dimethylaminoethyl methacrylate-metering system
12 parts of acid ester copolymer, 1200 parts of gasoline；
Wherein, zinc oxide is the mixture of Zinc oxide powder and zinc oxide fiber, and the percentage by weight of wherein zinc oxide fiber is
40wt%, Zinc oxide powder 60wt%；The length of zinc oxide fiber is 1mm, draw ratio 10；
Zinc oxide uses preceding through steps of processing：
Zinc oxide is added in the water of 5 times of zinc oxide weight, then adds the carboxymethyl cellulose of zinc oxide weight 20~35%
Element, and with 50rpm rotating speed magnetic agitation 15 minutes, afterwards with 15rpm rotating speed magnetic agitation 3 minutes after, it is cold using vacuum
Freeze dry removing liquid；When wherein vacuum freeze drying is handled, temperature is -15 DEG C, vacuum 10Pa.
A kind of preparation method for being used to prevent and treat the external plaster of coronary heart disease, comprises the following steps：
a）Stock：Stocked up by above-mentioned formula；
b）Pharmacy：The red sage root, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, myrrh, cloves, frankincense, dalbergia wood are ground into coarse powder, coarse powder particle diameter is less than 24
Mesh, and it is no more than 40wt% less than 65 purposes, the concentration that 0.7 times of coarse powder weight is then added into coarse powder is 90vol% second
Alcohol stands 45 minutes, is then transferred in percolator, and the ethanol for adding concentration to be 90vol% makes liquid level be higher by material 5cm, impregnates
Percolate is collected for 5mL/min by diacolation speed after 50 hours, finally by percolate at 55 DEG C, steam pressure is not more than
Concentrated under 0.01Mpa, vacuum 0.08MPa and liquid extract is made；The relative density of obtained liquid extract is 1.05；
c）Refining glue：Rubber is cut into the wide strips of 20cm, is put into afterwards in rubber mixing machine and rolls refining, is made and rolls refining rubber；
d）Cladding：By chitosan and dimethylaminoethyl methacrylate-methacrylate copolymer mix and to
Wherein add the absolute ethyl alcohol of both 60 times of weight and dissolving be obtained up to being completely dissolved at 70 DEG C, be subsequently added into liquid extract,
And be stirred continuously 40 minutes, liquid extract cladding material is made；
e）Mashing：Refining rubber will be rolled with solvent input mixer, stirring every 3 hours 2 minutes, stirring 2 times altogether, it is then quiet
Immersion 26 hours is put, first puts into camphor, musk xylene, menthol, bagodryl hydrochloride and borneol and 40 points of stirring thereto
Clock, rosin, vaseline stirring 4 hours is then put into thereto, put into, stir after then zinc oxide is mixed with liquid extract cladding material
Mix 2 hours, and rubber cement is made after being filtered with 5000 mesh bolting silks；
d）Gluing：Obtained rubber cement is coated on elastical cloth, and it is 0.5mg/cm to control paste containing amount2；
e）Drying：The elastical cloth for having coated rubber cement carries out drying and processing, the temperature of three baking zones by three baking zones successively
It is followed successively by 65 DEG C, 95 DEG C, 75 DEG C；
f）Post processing：The product of above-mentioned steps processing is cut, lining form, section and packing processes.
Gas permeability effect：
Textile method for testing air permeability and formula described in permeability test borrow GB/T5453-1997 is in the present invention
Emplastrum is tested and evaluated, and test area is the surface of whole emplastrum, and pressure drop 100Pa, airflow direction is by elastical cloth side
To rubber cement side is scribbled, air penetrability detects data in 85~110mm/s, although the gas permeability of emplastrum is compared with fabric in the present invention
Relatively there is larger gap（The gas permeability of fabric is generally in more than 250mm/s）, but relative to the emplastrum on existing market, its is saturating
Gas has substantially improved.
Slow release effect：Emplastrum in the present invention, active constituent content is still up to starting active constituent content after sticking 5 days
30% and more than, there is longer duration of efficacy than the emplastrum of existing 1~2 day action time.
It should be appreciated that to those skilled in the art, it can according to the above description be improved or be become
Change, and all these modifications and variations should all belong to the protection domain of appended claims of the present invention.
Claims (9)
1. a kind of external plaster for being used to prevent and treat coronary heart disease, it is characterised in that mainly by the raw material system of following parts by weight
：
100 parts of the red sage root, 90~110 parts of Ligusticum wallichii, 95~110 parts of Radix Angelicae Sinensis, 40~55 parts of safflower, 35~40 parts of myrrh, cloves 37~
38 parts, 36~38 parts of frankincense, 37~38 parts of dalbergia wood, 22~26 parts of camphor, 10~14 parts of musk xylene, menthol 22~27
Part, 4~6 parts of bagodryl hydrochloride, 45~60 parts of borneol, 400~500 parts of rubber, 350~400 parts of rosin, zinc oxide 420~
480 parts, 40~50 parts of vaseline, 5~10 parts of chitosan, dimethylaminoethyl methacrylate-methacrylate
8~12 parts of copolymer, 900~1200 parts of solvent.
A kind of be used to prevent and treat the external plaster of coronary heart disease 2. according to claim 1, it is characterised in that mainly by
The raw material of following parts by weight is made：
100 parts of the red sage root, 100 parts of Ligusticum wallichii, 100 parts of Radix Angelicae Sinensis, 50 parts of safflower, 37.5 parts of myrrh, 37.5 parts of cloves, 37.5 parts of frankincense,
37.5 parts of dalbergia wood, 25 parts of camphor, 12.5 parts of musk xylene, 25 parts of menthol, 5 parts of bagodryl hydrochloride, 50 parts of borneol, rubber
445 parts, 368 parts of rosin, 445 parts of zinc oxide, 43 parts of vaseline, 8 parts of chitosan, dimethylaminoethyl second
10 parts of ester-methacrylate copolymer, 1000 parts of solvent.
A kind of 3. external plaster for being used to prevent and treat coronary heart disease according to claim 1 or 2, it is characterised in that：
Described solvent is gasoline.
A kind of 4. external plaster for being used to prevent and treat coronary heart disease according to claim 1 or 2, it is characterised in that：
Described zinc oxide is the mixture of Zinc oxide powder and zinc oxide fiber, and the percentage by weight of wherein zinc oxide fiber is
35~40wt%, surplus are Zinc oxide powder；The length of zinc oxide fiber is 0.1~1mm, and draw ratio is 5~10.
5. a kind of external plaster for being used to prevent and treat coronary heart disease according to claim 4, it is characterised in that described
Zinc oxide uses preceding through steps of processing：
Zinc oxide is added in the water of 2~5 times of zinc oxide weight, the carboxymethyl for then adding zinc oxide weight 20~35% is fine
Dimension element, and with 41~50rpm rotating speed magnetic agitation 10~15 minutes, afterwards with 11~15rpm rotating speed magnetic agitation 1~3
After minute, liquid is removed using vacuum freeze drying；When wherein vacuum freeze drying is handled, temperature is -20~-15 DEG C, vacuum
Spend for 1.3~10Pa.
6. a kind of preparation method according to claim 1 or 2 for being used to prevent and treat the external plaster of coronary heart disease, it is special
Sign is to comprise the following steps：
a）Stock：Stocked up by above-mentioned formula；
b）Pharmacy：The red sage root, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, myrrh, cloves, frankincense, dalbergia wood are ground into coarse powder, then added into coarse powder
The ethanol that the concentration of 0.6~0.7 times of overstriking powder weight is 90vol% stands 30~45 minutes, is then transferred in percolator, and
The ethanol for adding concentration to be 90vol% makes liquid level be higher by 3~5cm of material, and dipping was 3~5mL/ by diacolation speed after 45~50 hours
Min collects percolate, and finally by percolate at 45~55 DEG C, steam pressure is not more than 0.01Mpa, and vacuum 0.06~
Concentrated under 0.08MPa and liquid extract is made；
c）Refining glue：Rubber is cut into the wide strips of 10~20cm, is put into afterwards in rubber mixing machine and rolls refining, is made and rolls refining rubber；
d）Cladding：By chitosan and dimethylaminoethyl methacrylate-methacrylate copolymer mix and to
Wherein add the absolute ethyl alcohol of both 50~60 times of weight and dissolving is obtained up to being completely dissolved at 50~70 DEG C, be subsequently added into
Liquid extract, and be stirred continuously 30~40 minutes, liquid extract cladding material is made；
e）Mashing：Refining rubber will be rolled with being standing and soak for 22~26 hours in solvent input mixer, first put into camphor, two thereto
Trinitro-tert-butyl-toluene, menthol, bagodryl hydrochloride and borneol simultaneously stir 30~40 minutes, then put into rosin, vaseline thereto
Stirring 3~4 hours, put into after then mixing zinc oxide and liquid extract cladding material, stirring 1~2 hour, and with 4500~5000
Rubber cement is made after the filtering of mesh bolting silk；
f）Gluing：Obtained rubber cement is coated on elastical cloth, and it is 0.3~0.5mg/cm to control paste containing amount2；
g）Drying：The elastical cloth for having coated rubber cement carries out drying and processing, the temperature of three baking zones by three baking zones successively
It is followed successively by 55~65 DEG C, 85~95 DEG C, 65~75 DEG C；
h）Post processing：The product of above-mentioned steps processing is cut, lining form, section and packing processes.
7. a kind of preparation method for being used to prevent and treat the external plaster of coronary heart disease according to claim 6, its feature
It is：
In the step b, coarse powder particle diameter is less than 24 mesh, and is no more than 40wt% less than 65 purposes.
8. a kind of preparation method for being used to prevent and treat the external plaster of coronary heart disease according to claim 6, its feature
It is：
The relative density of obtained liquid extract is 1.05 in the step b.
9. a kind of preparation method for being used to prevent and treat the external plaster of coronary heart disease according to claim 6, its feature
It is：
In the step e, roll and stirred 2 minutes every 3 hours before refining rubber is standing and soak for solvent, stirred 2 times altogether.
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| CN201710682379.2A CN107456484A (en) | 2017-08-10 | 2017-08-10 | It is a kind of to be used to prevent and treat external plaster of coronary heart disease and preparation method thereof |
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| CN101700308A (en) * | 2009-11-20 | 2010-05-05 | 天津市普善医药器械股份合作公司 | Paste for treating hyperosteogeny |
| CN204072474U (en) * | 2014-07-15 | 2015-01-07 | 牛太贵 | The special anti-bacterial fibre plaster of gynecological |
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2017
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|---|---|---|---|---|
| CN1110600A (en) * | 1995-01-17 | 1995-10-25 | 河南省焦作市卫生材料厂 | Antalgic paster and its preparation method |
| CN1813912A (en) * | 2005-12-19 | 2006-08-09 | 李秀花 | Ointment for treating coronary disease and its production process |
| CN101700308A (en) * | 2009-11-20 | 2010-05-05 | 天津市普善医药器械股份合作公司 | Paste for treating hyperosteogeny |
| CN204072474U (en) * | 2014-07-15 | 2015-01-07 | 牛太贵 | The special anti-bacterial fibre plaster of gynecological |
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Application publication date: 20171212 |