CN107913373A

CN107913373A - A kind of Chinese medicine composition and application for being used to treat hematologic malignancy

Info

Publication number: CN107913373A
Application number: CN201711212718.7A
Authority: CN
Inventors: 袁仕忠
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-11-28
Filing date: 2017-11-28
Publication date: 2018-04-17

Abstract

The invention discloses a kind of Chinese medicine composition for being used to treat Malignant hematologic diseases, including following components：10 30 parts of cockroach, 25 45 parts of common camptotheca bark, 26 parts of jequirity, 20 40 parts of oolong root, 20 40 parts of Radix Salviae Miltiorrhizae, 25 45 parts of Soil unit, 25 parts of castor bean, 20 40 parts of rhizoma imperatae, 10 30 parts of hairyvein agrimony, 10 30 parts of Radix Caulophylli, 15 35 parts of Glabrous Sarcandra Herb, 160 240 parts of gypsum, 15 35 parts of selfheal, 10 30 parts of rock mulberry, and remaining totally 36 kinds of component.The composition is applied in hematologic malignancy, can effectively kill cancer cell, reach clinical cure standard, and long term follow-up does not recur.

Description

A kind of Chinese medicine composition and application for being used to treat hematologic malignancy

Technical field

The present invention relates to tcm field, be specially a kind of Chinese medicine composition for being used to treat hematologic malignancy and Using.

Background technology

Blood circulation system is made of blood, blood vessel and heart.Blood is made of four kinds of components：Blood plasma, red blood cell are white thin Born of the same parents, blood platelet.Blood plasma accounts for the 55% of blood, is water, sugar, fat, protein, the mixture of sylvite and calcium salt, haemocyte and Other the 45% of blood platelet composition blood.And composition goes wrong at any of the above described one, disease in the blood system will be triggered, at present Clinically handling more difficult Malignant hematologic diseases includes leukaemia and alpastic anemia.

Leukaemia is Hematopoietic Malignancies, due to candidate stem cell disdifferentiation, in blood or marrow leucocyte and Its juvenile cell (i.e. leukaemia or cancer cell) hyperplasia, the normal hematopoiesis function of marrow are damaged, can not be autonomous Hematopoiesis, patient need to rely on blood transfusion and blood platelet to sustain life, but final result is often the death of patient.This old complaint is according to cell class Type can be divided into lymphatic, myeloid, granulocytic etc.；Again can be according to the jejune degree of leukaemia and white blood The natural history of disease is classified as two major class of acute leukemia and chronic leukemia.

The traditional Chinese medical science is studied history no leukaemia name of disease, is attributed to " mass formed by blood stasis " " acute pulmonary tuberculosis " " hot labor " " damp evil " more.Trace it to its cause as healthy tendency Deficiency, accumulates in cult poison, impairment of yin blood, damage marrow " stasis of blood is stagnant in marrow " and fall ill.Nowadays right cult poison is not fallen ill immediately, but deep volt in Marrow, accumulation morbidity, through treatment, Healthy energy reises and evil falls, and cult poison volt deeply inside accumulates in brain in marrow, initiation recurrence dealt with improperly, in dialogue In blood disease Pathologic Study, it was demonstrated that syndrome of blood stasis is the pathologic basis of leukaemia.Leukaemia is divided into anxious marrow poison in vain by modern Chinese medicine The sick and slow marrow poison leukaemia of blood.

At present in clinical treatment, chemotherapy is still the main method for the treatment of leukaemia, but still has some patientss chemotherapy effect not It is good, and recurrence, adverse reaction and the multidrug resistance after chemotherapy also bring inconvenience for clinical treatment.

The content of the invention

The present invention provides a kind of Chinese medicine composition, and the composition can effectively control bleeding and the hyperpyrexia of leukemia patient Shape, treats the damage of the vital organs of the human body caused by chemotherapy, by detoxicating and resolving a mass, combats poison with poison, nourishing yin and lessening fire, and dehumidify sharp hydrops, helps The means such as healthy tendency, dredging the channel blood vessel, treat patient on the whole.Composition of the present invention can effectively kill cancer cell, The leucocyte and platelet count of patient is improved, is good for patient's taste again, strengthens patient's immunity, reaches clinical cure standard, and Do not recurred through long term follow-up.

To solve the above problems, the present invention provides a kind of Chinese medicine composition for being used to treat Malignant hematologic diseases, its It is characterized in that, in terms of parts by weight, including following components：

Preferably, in terms of parts by weight, including following components：

It is more highly preferred to, in terms of parts by weight, including following components：

The present invention also provides preparation made of a kind of Chinese medicine composition and pharmaceutically acceptable auxiliary material.

Preferably, the preparation is one or more in pill, granule, capsule, oral liquid.

Preferably, the preparation is granule.

The present invention also provides the application of above-mentioned composition and its preparation in hematologic malignancy is treated.

Preferably, the hematologic malignancy includes leukaemia and alpastic anemia.

Preferably, the leukaemia includes acute leukemia and chronic leukemia.

It is more highly preferred to, the acute leukemia includes acute myeloblastic leukemia and acute myeloid leukemia.

Composition of the present invention, wherein Radix Caulophylli are Berberidaceae plant Radix Caulophylli Caulophyllum robustum Maxim. root and rhizome.With promoting blood circulation to remove blood stasis, the effect of dispelling wind and eliminating dampness, promoting qi circulation and relieving pain.It is usually used in irregular menstruation, dysmenorrhoea, production Abdominal pain due to blood stasis afterwards, gastral cavity abdomen are trembled with fear bitterly, traumatic injury, arthralgia pain due to rheumatism.Rhizoma imperatae is grass cogongrass Imperata The dry rhizome of cylindrica Beauv.var.major (Nees) C.E.Hubb., nature and flavor are sweet, tremble with fear, return lung, stomach, bladder warp, With cooling blood and hemostasis, the effect of reducing fever and causing diuresis, spit blood for blood-head, bleeding from five sense organs or subcutaneous tissue, hematuria, pyreticosis polydipsia, cough with lung heat, stomach energy vomits Spit, jaundice with damp-heat pathogen, oedema oliguria, puckery pain of heat gonorrhea.Hairyvein agrimony, is the dry aerial parts of rosaceous plant Agrimony.Summer, autumn two Season cauline leaf it is luxuriant when tap, remove impurity, it is dry.Bitter, it is puckery, put down, converge to heart and liver channels.With astringing to arrest bleeding, preventing malaria, stop dysentery, solution The effect of poison, qi-restoratives.For spitting blood, spit blood, metrostaxis, malaria, bloody flux, carbuncle sore tumefacting virus, under pruritus vulvae band, de-power internal lesion caused by overexertion.This Invent in the composition using Radix Caulophylli, rhizoma imperatae and hairyvein agrimony control bleeding.

Gypsum is the ore of hydrous calcium sulfate (CaSO42H2O), sweet in flavor, pungent, in property Great Cold, is attached to the lung and stomach meridians.It is raw with having The effect of clearing heat-fire, relieving restlessness is quenched the thirst；Forge to use and there is the effect of expelling pus and promoting granulation, hygroscopic, hemostasis.It is usually used in fever caused by exogenous pathogenic factors, high fever Polydipsia, dyspnea and cough due to lung-heat, the high Sheng of stomach fire, has a headache, toothache.Selfheal is dicotyledon Labiatae Labiatae selfheals The drying fruit ear of Prunella vulgarisLinn..Acrid flavour, hardship, tremble with fear, Return liver, gallbladder channel, main fever and chills, scrofula, mouse fistula, head sore, Broken disease.Cure mainly scattered goitre knot gas, foot swells arthritis with fixed pain caused by dampness.Rock mulberry, alias Ci Yesang, is moraceae plants；Deciduous tree, also there is a shrub, leaf, Fruit, branch, root skin can be used as medicine, and have heat-clearing except fire, moistening lung, brighten the hair, improving eyesight, the effect of anti-inflammatory analgetic.Of the present invention group Mainly with gypsum, selfheal, rock mulberry control high fever in compound.

Soil unit also known as eupolyphoge sinensis, are Corydiidae eupolyphagasinensis walker Eupolyphaga sinensis or polyphagaplancyi Steleophaga The female adult hirudo leech of plancyi (Boleny).After seizure, put in boiling water and scald extremely, dry or dry.Nature and flavor are salty, tremble with fear, slightly poisonous, Return liver warp, has the effect of broken stasis of blood blood, continuous muscles and bones.For injured bone, blood stasis closed, abdominal mass lump in the abdomen.Radix Salviae Miltiorrhizae, is labiate The dry root and rhizome of Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge., has promoting blood circulation, and inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire is cool Blood disappear carbuncle the effect of.For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea warp Close, sore swell and ache curative.Oolong root is the dry root of Rhamnaceae plant berchemia lineata Berchemia lineata (L.) DC., bitter in taste It is flat, there is Removing Blood Stasis, wind-damp dispelling, detumescence poison and other effects, for tuberculosis chronic cough, spit blood, spit blood, traumatic injury, rheumatalgia pain, carbuncle It is swollen, nettle rash.The symptoms such as hepatosplenomegaly, visceralization, enlargement of lymph nodes are included in leukaemia related symptoms, therefore in this composition Treat internal organs using Soil unit, Radix Salviae Miltiorrhizae, oolong radical cure and damage.

Wooden small pin for the case also known as semen momordicae, are cucurbitaceous plant Momordica cochinchiensis Momordica cochinchinensis (Lour.) Spreng. dry mature seed, bitter in taste, micro-sweet is cool, poisonous, Return liver, spleen, stomach, has mass dissipating and swelling eliminating, attacks poison and treats sore The effect of, for treating sore swollen toxin, acute mastitis, scrofula, hemorrhoid complicated by anal fistula, chronic eczema, the favus of the scalp.Selfheal is labiate selfheal The drying fruit ear of Prunella vulgaris L., nature and flavor are pungent, bitter, tremble with fear, Return liver, gallbladder channel.With clearing heat-fire, improving eyesight, dissipating bind The effect of detumescence, for treating red eye, swell pain, dizziness of having a headache, mesh pearl nyctalgia, scrofula, goiter and tumor, acute mastitis swelling and pain.Vomiting nut is Strychnos nux-vomica The dry mature seed of section plant Strychnos nux-vomica Strychnos nux-vomica L., bitter in taste, temperature；It is very toxic, Return liver, the spleen channel, tool There is the effect of excited stomach invigorating, detumescence poison, cool blood, cure mainly numb limb, paralysis, loses the appetite, lump in the abdomen, ulcerative carbuncle pyogenic infections, and throat swells Bitterly.Giant knotweed is the dry rhizome and root of polygonaceae plant giant knotweed Polygonum cuspidatum Sieb.et Zucc..Spring, autumn two Season excavates, and removes fibrous root, cleans, takes advantage of fresh-cut short section or sheet, dry.Mildly bitter flavor, cold nature, Return liver, courage, lung channel, have profit Wet removing jaundice, clearing heat and detoxicating, removing blood stasis and analgesics, it is relieving cough and reducing sputum the effect of, for jaundice with damp-heat pathogen, stranguria with turbid discharge, under band, arthralgia pain due to rheumatism, carbuncle swells Sore, scald, Amenorrhea, abdominal mass, instep beat damage, cough with lung heat.This composition using wooden small pin for the case, selfheal, vomiting nut with And giant knotweed carrys out detoxicating and resolving a mass.

Cudrania root is Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudrania cochin chinensis (Lour.) Kudo et Masam., it is used as medicine with root, whole year can adopt, and clean section is dried, nature and flavor slight bitter, put down, have relieving cough and reducing sputum, expelling wind and removing dampness, dissipate the stasis of blood The effect of analgesic.For pulmonary tuberculosis, icteric hepatitis, hepatosplenomegaly, taste-blindness rate, rheumatic lumbocrural pain；External application is controlled Fracture, traumatic injury.Lygodium japonicum is being dried to for Lygodiaceae plant Lygodium japonicum Lygodium japonicum (Thunb.) Sw. Ripe spore.Autumn spore taps cane leaves when not falling off, and dries, and crumples or lay spore, removes cane leaves and is made.It is sweet in flavor, salty, property It is cold, return bladder, small intestinl channel, have the effect of eliminating dampness and heat, treating stranguria analgesic, for heat gonorrhea, urolithiasis, blood strangury, cream leaching, Urethra astringent pain. Honeysuckle stem also known as caulis lonicerae, the drying stem branch of caprifoliaceae plant honeysuckle is sweet in flavor, trembles with fear, attaches to the lung and stomach meridians, have clearing heat and detoxicating, dispelling wind The effect of dredging collateral, cure mainly warm disease heating, toxic-heat and blood stasis, carbuncle swells sore, beriberoid pyretic arthralgia, redness and swelling of joints heat pain.Make in this composition Removed with cudrania root, Lygodium japonicum and honeysuckle stem damp and hot.

The herb that thousand hammerings are Gesneriaceae Lysionotus carnosus Hemsl. (Lysionotus pauciflorus Maxim.) Lysionotus pauciflorus Maxim., sweet in flavor, Hardship, it is cool in nature, there is the effect of clearing lung and eliminating phlegm, dispelling wind and eliminating dampness, promoting blood circulation for regulating menstruation, cure mainly tuberculosis chronic cough, spit blood, pertussis, lung abscess, Bronchial asthma, diabetes, decoct soup are washed for controlling mange itch.Huaihe River leads to for Aristolochiaceae birthwort Baoxing birthwort Aristolochia moupinensis Franch., are used as medicine with root and stem, and spring and autumn collection, respectively section is dried.Bitter, tremble with fear, With the effect of clearing heat and promoting diuresis, row is newborn under water, Apocenosis pain relieving.For difficult urination, oedema, urinary tract infections, Trichomonas vaginalis, rheumatism Arthralgia, eczema, nettle rash, carbuncle swells.Akebia trifoliata varaustralis, acrid flavour, puts down, enters the heart, small intestine, bladder warp, purging intense heat row water is promoting blood circulation.It is main Hot urination is controlled, stranguria with turbid discharge, oedema is irritable feverish sensation in chest, larynx numbness pharyngalgia, inflexible pain all over, women's Amenorrhea, alactation.Moleplant seed, is big The dry mature seed of halberd section plant Euphorbia lathyris Euphorbia lathyris L..Acrid flavour, warm-natured, Return liver, kidney, large intestine channel, tool The effect of expelling water retention with drastic purgative, drug of breaking blood stasis to resolve lumps, for constipation and anuresis, oedema, phlegm and retained fluid, stagnate turgor, blood stasis；Stubborn dermatitis is controlled outside, is gone to live in the household of one's in-laws on getting married Wart.This composition is beaten using thousand, Huaihe River leads to, akebia trifoliata varaustralis and moleplant seed profit hydrops.

Ginseng scientific name is Panax ginseng, also known as Asia ginseng, is the root with meat, herbaceos perennial.Taste Sweet, slight bitter, warm-natured, flat, returns spleen, lung channel, the heart channel of Hang-Shaoyin.The effect of with tonifying Qi, prevent prolapse, promotes the production of body fluid, and calms the nerves, intelligence development, cures mainly physically weak desire Take off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung is breathed with cough, and injury thirst, Heat Diabetes, prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng；The heart Force failure, cardiogenic shock.RADIX POLYGONI MULTIFLORI PREPARATA is the Preparation process product of the fleece-flower root, and surface dark brown or sepia are uneven.Matter is hard Firmly, section cutin sample, sepia or black.Gas is micro-, and taste micro-sweet is bitter, has help essence and blood, and nourishing the liver is calmed the nerves, strengthening the bones and muscles, Gu The effect of kidney crow palpus, Light-headedness is seen for the deficiency of blood, palpitation and insomnia is forgetful, sallow weak, the dizziness ear of liver kidney blood and essence asthenia The diseases such as band, poliosis are collapsed in ring, soreness and weakness of waist and knees, seminal emission.Semen Cuscutae, is convolvulaceous plant Cuscuta australis Cuscuta The dry mature seed of australis R.Br. or Semen Cuscutae Cuscuta chinensis Lam..It is acrid flavour, sweet, it is mild-natured, return The effect of liver,kidney,spleen passes through, and has and tonifies the liver and kidney, astringent sperm contracting urine, tocolysis, improving eyesight, antidiarrheal, external application has the effect of disappearing wind nti-freckle. It is usually used in kidney deficiency and liver, soreness and weakness of waist and knees, impotence and seminal emission, enuresis frequent micturition, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, blurred vision tinnitus, spleen kidney deficiency Rush down；Externally treating leucoderma.Ginseng, RADIX POLYGONI MULTIFLORI PREPARATA and Semen Cuscutae are used for righting gas in this combination.

Bubble ginseng is four leaf the root of straight ladybell apricot leaf the root of straight ladybell of Campanulaceae the root of straight ladybell platymiscium or its congener, is used as medicine with root.Alias Nansha Ginseng, the root of straight ladybell, bubble the root of straight ladybell, can clearing heat and nourishing yin, moisten the lung and relieve the cough.Cure mainly tracheitis, pertussis, cough with lung heat, cough up phlegm yellow thick.Ophiopogon is The dried root of liliaceous plant ophiopogon.Summer excavates, and cleans, is exposed to the sun repeatedly, to doing very likely, removes fibrous root, dry.Taste Sweet, slight bitter, cold nature, returns stomach, lung, the heart channel of Hang-Shaoyin, there is the effect of Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire, for dryness of the lung dry cough, The diseases such as cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines.American Ginseng scientific name is Panax Quinquefolius is Araliaceae Panax herbs perennial vegetation, alias American ginseng, American ginseng, Western ginseng.It is cool in nature, sweet in flavor, Slight bitter, boosting qi and nourishing yin, clearing heat and promoting fluid.For deficiency of vital energy yin deficiency, interior heat, cough and asthma phlegm blood, abnormal heat is tired of tired, is quenched one's thirst, the dry larynx of mouth is done.This group Bubble ginseng, ophiopogon and American Ginseng are used for nourishing yin and lessening fire in compound.

The membrane of a chicken's gizzard is the drying inner wall of sandbag of Phasianidae animal family chicken Gallusgallusdomesticus Brisson.Kill chicken Afterwards, chicken gizzard is taken out, peels inner wall, cleaning, drying immediately.Taste sweet and neutral, returns spleen, stomach, small intestine, bladder warp.With stomach strengthening and digestion promoting, Arresting seminal emission, the effect for the treatment of stranguria fossil.For dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of urolithiasis, courage Swollen hypochondriac pain.Radix Codonopsis source is the dry root of Campanulaceae Radix Codonopsis, codonopsis pilosula var. modesta or radix codonpsis tangshen etc., and autumn excavation, cleans, shine It is dry.It is sweet in flavor, it is mild-natured.There is tonifying middle-Jiao and Qi, quench the thirst, strengthening spleen and tonifying lung, the effect of nourishes blood and promotes the production of body fluid.For spleen-lung Qi deficiency, eat less and tired, cough Void of coughing asthma, insufficiency of vital energy and blood, sallow complexion, palpitation, injury thirst, Heat Diabetes, lack of desire to speak and qi, weakness of limbs, appetite are not The diseases such as the good, deficiency of vital energy, deficiency of qi and fluid, deficiency of qi and blood and blood deficiency chlorosis.Rhizoma Atractylodis Macrocephalae alias small wooden raft Ji, Yu Shu, winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, piece art, rhizoma atractylodis etc., belongs to composite family, [WTBX herbaceos perennial.The nice and cool weather of happiness, is used as medicine with rhizome, and bitter is sweet, It is warm-natured.Returns spleen, stomach.Has the effect of strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis.For spleen eating less, abdominal distention diarrhea, phlegm and retained fluid Feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability.For spleen eating less, diarrhea loose stool, fetal irritability.This composition is using the membrane of a chicken's gizzard, party Ginseng, Rhizoma Atractylodis Macrocephalae rebuild taste.

It is deep to disappear also known as Longtube Ground Ivy Herb, it is the dry aerial parts of labiate blood circulation promoting pill, spring to autumn harvesting, except impurity elimination Matter, is dried.Acrid flavour, slight bitter, are slightly cold.Return liver, kidney, bladder warp.The effect of tool dampness removing is treating stranguria, clearing heat and detoxicating, eliminating stasis to subdue swelling.For Heat gonorrhea, urolithiasis, jaundice with damp-heat pathogen, sore, carbuncle and painful swelling, injury from falling down.Wen Shuwei plant Zingiber curcuma zedoary Curcuma zedoaria (Berg.) root-like stock of Rosc..Bitter, sweet, warm.Returns spleen, stomach.There are strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, the work(of tocolysis Effect.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.Radix Salviae Miltiorrhizae is labiate Radix Salviae Miltiorrhizae The dry root and rhizome of Salvia miltiorrhiza Bge..Spring, the excavation of two season of autumn, remove silt, and dry, bitter, is slightly cold, Converge to heart and liver channels.It is inducing meastruation to relieve menalgia with promoting blood circulation, the effect of relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.For chest impediment and cardialgia, the gastral cavity abdomen side of body Bitterly, lump in the abdomen lump in the abdomen is gathered, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.The root of Chinese clematis is cohosh prestige Medicine xiaolingxian Clematis chinensis Osbeck, Clematis hexapetala Clematis hexapetala Pall. or northeast clematis The dry root and rhizome of Clematis manshurica Rupr..Autumn excavates, and removes silt, dries.It is acrid flavour, salty, it is warm-natured, Return bladder warp.There are wind-damp dispelling, the effect of degrading the channel, for arthralgia pain due to rheumatism, extremity numbness, muscle arteries and veins contraction, joint stuffiness.This combination It is deep in thing disappear, Wen Shu, Radix Salviae Miltiorrhizae, Soil unit are used for dredging the channel blood vessel.

Complete stool or full root of the Glabrous Sarcandra Herb for Chloranthaceae plant Chloranthus glaber Sarcandra glabra (Thunb.) Nakai., Summer harvests, and dries.It is mild-natured, bitter, pungent, thoughts of returning home warp, Liver Channel.With dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis, it is clearing heat and detoxicating the effect of. Arthralgia pain due to rheumatism is cured mainly, extremity numbness, traumatic injury, fracture, dysmenorrhoea, postpartum stasis of blood, cough with lung heat, dysentery, has a toothache, Acute appendicitis, sore swells.Its pharmaceutical research is shown, Glabrous Sarcandra Herb volatile oil, medicinal extract are to 615 cell of leukaemia, TM755, adenocarcinoma of lung 615th, Spontaneous Breast Cancer 615, spontaneous ascitic type AL771, ehrlich ascites cancer, sarcoma 180, sarcoma 37, a watt gram cancer 256 have necessarily Inhibitory action.Concentration 1：7 Herba Sarcandrae total flavones glycosides, in vitro has ehrlich ascites cell in stronger killing effect, abdominal cavity Administration 8 days, to the inhibiting rate of cancer cell up to 70.8%.And itself or cellular respiration inhibitor, move oncocyte and lotus knurl The oxygen-consuming capacity of thing liver has direct inhibitory action.

Jequirity also known as rde bean, red bean, are the seed of legume red bean Phaseolus angularis Wight, It is mild-natured, it is sweet in flavor, sour, enter the heart, small intestinl channel, there is the effect of Li Shui dehumidifying, and blood apocenosis, subdhing swelling and detoxicating.Cure mainly oedema, tinea pedis, Jaundice, rush down dysentery, has blood in stool, carbuncle swells.

It can extract out the abrin (Abrin) of structure similar to ricin, such toxalbumin in jequirity And the combination of the lactosylated residues monose acceptor of cell surface is common, and binding site includes the sugar of more than two.With neural ammonia Acid treatment cell, can increase binding site.At present it has been proved that the monose chain of tumor cell surface is had any different with normal cell, Its glycoprotein has excessive sialic acid, and glycolipid often contains incomplete chain.Incomplete chain is easily combined with toxalbumin, this can be used for solving Release the antitumaous effect of this kind of toxalbumin.

Castor bean is the seed of euphorbia plant castor-oil plant, and processing means pick benevolence use to break seed hull into pieces.With disappearing It is swollen to draw out pus by applying a plaster to the affected part, rush down the effect of lower logical stagnant.Control swollen ulcer drug, scrofula, larynx numbness, scabies leprosy tinea sore, oedema abdomen expires, dry feces.

Containing ricin in castor bean, ricin can be synthesized with the protein of the various cancer cells of strong inhibition, Moderate strength suppresses DNA synthesis, and the suppression to RNA synthesis is slight.Rabbit reticulocyte lysis is produced according to ricin Cell free system (mono- free system of Cell) protein synthesis of thing (Iysaie) has strong inhibitory action, it was demonstrated that it The extraction of the carbothdrate metabolism or amino acid that influence cancer cell it is not, but the protein for consumingly suppressing eucaryote ribosome closes Into.Ricin has two peptide chains, is connected by mono- S chains of S.There is a cracking process before having an effect, A is discharged after cracking Chain and B chains, A chains are referred to as effect chain (Effectoner)；B chains are referred to as marriage chain (Haptomer) B chains can be with cell The carbohydrate acceptor on surface combines, and free A chains or whole toxalbumin molecule is brought into endochylema by plasma membrane, with nucleoprotein Body 60S subunits are had an effect, and are suppressed aminoacyl t-RNA and are combined with the enzyme of ribosome, reduce the elongation factors of nucleic acid, so that Nucleic acid is inactivated, suppresses protein synthesis, and cause cell death.

Cockroach is Blattidae Periplaneta animal American cockroach Periplaneta americana (Linnaeus), Australia roach Lian Periplaneta australasiae (Fabricius), blattaria category animal oriental cockroach Blatta orientalis Linnaeus. entirety.The effect of taste is salty, cold in nature, Return liver, spleen, kidney channel, has and dissipates the stasis of blood, changes and accumulates, removing toxic substances.Cure mainly that a lump in the abdomen causing distension and pain, Infantile malnutrition, larynx numbness, acute tonsillitis, ulcerative carbuncle pyogenic infections, worm snake bite.There are many scientific research institutions and medical colleges and schools to resist American cockroach at present Function of tumor has done system research, it is found that American-cockroach-extract there is growth to press down the cancer of the esophagus, sdenocarcinoma of stomach, colon cancer cell line Make and use；Growth to Mice Bearing Lewis Lung Cancer and 3LL lung cancer tumor tissues has certain inhibitory action, tumour cell can be promoted to wither Die；It is white to oophoroma, cervical carcinoma, Prostatic cancer cell lines, chronic marrow-derived leukocythemia, promyelocytic leukemia, mouse in vitro Blood disease cell line, pharynx cancer, lung cancer, oral squamous carcinoma cell strain have growth inhibition effect.

Common camptotheca bark is the bark of Nyssaceae plant camptotheca acuminata Camptotheca acuminate Decne., and bitter is cold in nature, Return liver warp, has the effect of promoting blood circulation and detoxication, dispelling wind and arresting itching, cures mainly psoriasis.The component camptothecine wherein extracted has a variety of Pharmacological action, including antitumor action, immunosuppressive action, no matter in vivo or external it is, there is significant suppress into fibre The effect of hyperplasia is tieed up, and also has obvious inhibitory action to herpesviral.Camptothecine and the like is topoisomerase The specific inhibitor of enzyme I (topoisomerase I), it can suppress to be significantly higher than in normal structure in s phase tumour cells Topo I, cause DNA damage, so that the optionally DNA replication dna of Inhibit proliferaton phase tumour cell, to metastatic knot, rectum The kinds of tumors such as cancer, refractory ovarian cancer have significant curative effect.Into after clinic, camptothecine is in treatment stomach cancer, carcinoma of the colon and rectum, liver The malignant tumours such as cancer, leukaemia have good therapeutic effect.

It is thin using its therefore composition jequirity, castor bean, cockroach and common camptotheca bark of the present invention have cytotoxicity Cytotoxicity can kill tumour cell, and Glabrous Sarcandra Herb has the function that auxiliary kills cancer cell.

According to the principles of formulating prescriptions of Chinese medicinal formulae monarch, i.e., " the meaning monarch of main ingredient, the drug in a prescription helping monarch-drug is called miniSter, answering the meaning of minister makes.” Principle.In this composition, with jequirity, castor bean, cockroach, Glabrous Sarcandra Herb and Radix Caulophylli, rhizoma imperatae, hairyvein agrimony, gypsum, Selfheal, rock mulberry, Soil unit, Radix Salviae Miltiorrhizae, oolong root are as monarch drug in a prescription, directly kill tumour cell and the major blood for leukaemia of assaulting the main target Systemic symptom, with wooden small pin for the case, selfheal, vomiting nut, giant knotweed, cudrania root, Lygodium japonicum, the magnificent rattan of silver, thousand beat, Huaihe River leads to, akebia trifoliata varaustralis And moleplant seed is ministerial drug, main attack leukaemia other related symptoms, ginseng, RADIX POLYGONI MULTIFLORI PREPARATA, Semen Cuscutae, bubble ginseng, ophiopogon, American Ginseng, The membrane of a chicken's gizzard, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, it is deep disappear, Wen Shu, Radix Salviae Miltiorrhizae, Soil unit to assist, pass through nourishing yin and lessening fire, righting gas, reconstruction patients stomach and intestine Road system, from overall comprehensive healing patient.

Composition of the present invention can the effectively bleeding of palliating leukemia patient and fervescence, treat five caused by chemotherapy The damage of dirty six internal organs, by detoxicating and resolving a mass, combats poison with poison, nourishing yin and lessening fire, and dehumidify sharp hydrops, righting gas, dredging the channel blood vessel etc. Means, cure patient on the whole.Composition of the present invention can effectively kill cancer cell, improve the leucocyte and blood of patient Platelet number, is good for patient's taste again, improves life in patients, to leukaemia and alpastic anemia, can reach clinical Criterion of cure, and long term follow-up does not recur.

Embodiment

In order to make those skilled in the art more fully understand the technical solution of invention, with reference to embodiment pair The present invention is described in further detail.

Leukaemia (leukemia) is one group of heterogeneity malignant clone disease, is that candidate stem cell or progenitor cells mutation are drawn The Hematopoietic Malignancies risen, have the characteristics that treatment cycle is long, the death rate is high.

Alpastic anemia referred to as hinders again, is one group of marrow hematopoiesis function failure synthesis caused by Different types of etiopathogenises Sign, characterized by myeloid element hypoplasia and peripheral blood whole blood trace elements, clinic is based on anaemia, bleeding and infection Show.The definite cause of disease is not yet clear and definite, then hinder morbidity may be related with chemicals, radioactive ray, virus infection and inherent cause. Hinder again and be mainly seen in person between twenty and fifty, its onset peak period there are 2, i.e. the age group of 15~25 years old and old group of more than 60 years old.Man Property incidence is slightly above women.Heavy and non-heavy type is divided into again according to the order of severity of marrow failure and clinical disease course progress Barrier and acute and chronic hinder again.

Treatment leukaemia is largely killing cancer cell all based on chemotherapy, but due to the therapy that it is non-selectivity at present While, also major injury itself normal cell, causes serious adverse reaction, influences the therapeutic effect of patient.Regeneration is hindered The treatment of impenetrability anaemia includes supportive treatment and disease specific aim goal treatment two parts.The purpose of supportive treatment is prevention and controls Treat haemocyte and reduce relevant complication；Goal treatment is then the candidate stem cell that supplement and replacement are extremely reduced and are damaged, but The disease cannot be all cured completely, can only play the role of relief of symptoms.

Conventional medicament of the traditional Chinese medicine as China, has the advantages that cheap, adverse reaction is small, and it is a variety of to have studied confirmation Chinese medicine and its active ingredient have leukemia resisting action.And using diagnosis and treatment as the Chinese medicine compound prescription of guiding theory in anti-leukocythemia and The pharmaceutically-active limitation of single can be made up in terms of reversing drug-resistant leukemia, plays synthesis, Mutiple Targets, the anti-leukocythemia of multipath Effect.

Above-mentioned elaborating for the present invention, is the embodiment of the present invention below.

Embodiment one

Chinese medicine composition decoction

Raw material：30 parts of cockroach, 45 parts of common camptotheca bark, 40 parts of ginseng, 40 parts of American Ginseng, 50 parts of cudrania root, 6 parts of jequirity, system 60 parts of the tuber of multiflower knotweed, 60 parts of Semen Cuscutae, 8 parts of Semen Strychni (processed), literary 30 parts of art, 50 parts of Rhizoma Atractylodis Macrocephalae, 50 parts of ophiopogon, 40 parts of oolong root, Radix Codonopsis 40 Part, bubble ginseng 35 parts, 30 parts of the membrane of a chicken's gizzard, 40 parts of Radix Salviae Miltiorrhizae, it is deep disappear 22 parts, Huaihe River lead to 40 parts, 45 parts of Soil unit, 5 parts of castor bean, moleplant seed 9 parts, 40 parts of rhizoma imperatae, 30 parts of hairyvein agrimony, wooden 9 parts of small pin for the case, 30 parts of Radix Caulophylli, 40 parts of akebia trifoliata varaustralis, 35 parts of giant knotweed, Glabrous Sarcandra Herb 35 Part, 30 parts of the root of Chinese clematis, 40 parts of honeysuckle stem, 40 parts of Lygodium japonicum, 240 parts of gypsum, 35 parts of selfheal, 30 parts of rock mulberry, thousand beat 30 parts.

Step：Above-mentioned medicinal material is taken, adds 2-3 times of volume of water, is decocted twice, decocts 0.5h every time, merging filtrate, obtains soup Agent.

Embodiment two

Chinese medicinal composition granules

Raw material：10 parts of cockroach, 25 parts of common camptotheca bark, 20 parts of ginseng, 20 parts of American Ginseng, 30 parts of cudrania root, 2 parts of jequirity, system 40 parts of the tuber of multiflower knotweed, 40 parts of Semen Cuscutae, 4 parts of Semen Strychni (processed), literary 10 parts of art, 30 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of ophiopogon, 20 parts of oolong root, Radix Codonopsis 20 Part, bubble ginseng 15 parts, 10 parts of the membrane of a chicken's gizzard, 20 parts of Radix Salviae Miltiorrhizae, it is deep disappear 15 parts, Huaihe River lead to 20 parts, 25 parts of Soil unit, 2 parts of castor bean, moleplant seed 5 parts, 20 parts of rhizoma imperatae, 10 parts of hairyvein agrimony, wooden 5 parts of small pin for the case, 10 parts of Radix Caulophylli, 20 parts of akebia trifoliata varaustralis, 15 parts of giant knotweed, Glabrous Sarcandra Herb 15 Part, 10 parts of the root of Chinese clematis, 20 parts of honeysuckle stem, 20 parts of Lygodium japonicum, 160 parts of gypsum, 15 parts of selfheal, 10 parts of rock mulberry, thousand beat 10 parts.

Step：Above-mentioned medicinal material is taken, is crushed, puts and suitably decocts in container, adds 4 times of amount water to make submergence medicinal material, when soaking suitable Between after, be heated to boiling, decoct twice, 30 minutes every time, separation merges fried liquid, and after sedimentation filtration, low temperature is concentrated and dried.

After taking powdered extract powder to be mixed with starch, cyclodextrin, heated-air drying removes a small amount of moisture below 80 DEG C, then Add 90% ethanol and softwood is made, wet grain is made with squash type comminutor, granule is obtained after dry whole grain.

Embodiment three

Chinese traditional medicine composition composition oral preparation

Raw material：25 parts of cockroach, 40 parts of common camptotheca bark, 35 parts of ginseng, 35 parts of American Ginseng, 45 parts of cudrania root, 5 parts of jequirity, system 55 parts of the tuber of multiflower knotweed, 55 parts of Semen Cuscutae, 7 parts of Semen Strychni (processed), literary 25 parts of art, 45 parts of Rhizoma Atractylodis Macrocephalae, 45 parts of ophiopogon, 35 parts of oolong root, Radix Codonopsis 35 Part, bubble ginseng 30 parts, 25 parts of the membrane of a chicken's gizzard, 35 parts of Radix Salviae Miltiorrhizae, it is deep disappear 20 parts, Huaihe River lead to 35 parts, 40 parts of Soil unit, 4 parts of castor bean, moleplant seed 8 parts, 35 parts of rhizoma imperatae, 25 parts of hairyvein agrimony, wooden 8 parts of small pin for the case, 25 parts of Radix Caulophylli, 35 parts of akebia trifoliata varaustralis, 30 parts of giant knotweed, Glabrous Sarcandra Herb 30 Part, 25 parts of the root of Chinese clematis, 35 parts of honeysuckle stem, 35 parts of Lygodium japonicum, 220 parts of gypsum, 30 parts of selfheal, 25 parts of rock mulberry, thousand beat 25 parts.

Step：Above-mentioned medicinal material is taken, is crushed, puts and suitably decocts in container, adds 4 times of amount water to make submergence medicinal material, when soaking suitable Between after, be heated to boiling, decoct twice, 30 minutes every time, separation merges fried liquid, and after sedimentation filtration, low temperature is concentrated and dried, and is added Enter appropriate 95% ethanol, simple syrup filtering and concentrating, obtain oral liquid.

Example IV

Chinese medicinal composition capsules agent

Raw material：15 parts of cockroach, 30 parts of common camptotheca bark, 25 parts of ginseng, 25 parts of American Ginseng, 35 parts of cudrania root, 3 parts of jequirity, system 45 parts of the tuber of multiflower knotweed, 45 parts of Semen Cuscutae, 5 parts of Semen Strychni (processed), literary 15 parts of art, 35 parts of Rhizoma Atractylodis Macrocephalae, 35 parts of ophiopogon, 25 parts of oolong root, Radix Codonopsis 25 Part, bubble ginseng 20 parts, 15 parts of the membrane of a chicken's gizzard, 25 parts of Radix Salviae Miltiorrhizae, it is deep disappear 16 parts, Huaihe River lead to 25 parts, 30 parts of Soil unit, 2 parts of castor bean, moleplant seed 6 parts, 25 parts of rhizoma imperatae, 15 parts of hairyvein agrimony, wooden 6 parts of small pin for the case, 15 parts of Radix Caulophylli, 25 parts of akebia trifoliata varaustralis, 20 parts of giant knotweed, Glabrous Sarcandra Herb 20 Part, 15 parts of the root of Chinese clematis, 25 parts of honeysuckle stem, 25 parts of Lygodium japonicum, 180 parts of gypsum, 20 parts of selfheal, 15 parts of rock mulberry, thousand beat 15 parts.

Step：Above-mentioned medicinal material is taken, is crushed, puts and suitably decocts in container, adds 4 times of amount water to make submergence medicinal material, when soaking suitable Between after, be heated to boiling, decoct twice, 30 minutes every time, separation merges fried liquid, and after sedimentation filtration, low temperature is concentrated and dried.Take Appropriate gauge capsulae vacuus, medicinal extract powder is packed into capsule, and by gumming, the sealing of capsule wind obtains capsule.

Embodiment five

Chinese medicine composition pill

Raw material：20 parts of cockroach, 35 parts of common camptotheca bark, 30 parts of ginseng, 30 parts of American Ginseng, 40 parts of cudrania root, 4 parts of jequirity, system 50 parts of the tuber of multiflower knotweed, 50 parts of Semen Cuscutae, 6 parts of Semen Strychni (processed), literary 20 parts of art, 40 parts of Rhizoma Atractylodis Macrocephalae, 40 parts of ophiopogon, 30 parts of oolong root, Radix Codonopsis 30 Part, bubble ginseng 25 parts, 20 parts of the membrane of a chicken's gizzard, 30 parts of Radix Salviae Miltiorrhizae, it is deep disappear 18 parts, Huaihe River lead to 30 parts, 35 parts of Soil unit, 3 parts of castor bean, moleplant seed 7 parts, 30 parts of rhizoma imperatae, 20 parts of hairyvein agrimony, wooden 7 parts of small pin for the case, 20 parts of Radix Caulophylli, 30 parts of akebia trifoliata varaustralis, 25 parts of giant knotweed, Glabrous Sarcandra Herb 25 Part, 20 parts of the root of Chinese clematis, 30 parts of honeysuckle stem, 30 parts of Lygodium japonicum, 200 parts of gypsum, 25 parts of selfheal, 20 parts of rock mulberry, thousand beat 20 parts.

Step：Above-mentioned medicinal material is taken, is crushed, puts and suitably decocts in container, adds 4 times of amount water to make submergence medicinal material, when soaking suitable Between after, be heated to boiling, decoct twice, 30 minutes every time, separation merges fried liquid, and after sedimentation filtration, low temperature is concentrated and dried.Take Powdered extract powder, mixes with honey, prepares the larger ball block of plasticity, then ball bar is made successively, and gradation, honey is obtained after rubbing circle with the hands Ball.

Embodiment six

Pharmacodynamic experiment

(1) facilitation of hematopoiesis in vivo

Animal：Kunming mouse, 18-22g, each 6 of male and female.

Medicine：Medicinal material medicinal extract powder described in embodiment 5.

Method：Medicine 5g is fed, 2 times/day, continuous 60 days.Set 0.1ml/ physiological saline as a control group at the same time.Experiment After put to death mouse, separate femur bone marrow mononuclearcell,

As a result：Using this research department's routine hematopoietic colonies generation experiment, GM-CFUc quantity is measured.It is the result shows that real The colony number of group is tested apparently higher than control group (P<0.05).

(2) vivo immunization facilitation

Animal：Kunming mouse, 18-22g, each 6 of male and female.

Method：Medicine 5g is fed, 2 times/day, continuous 20 days.Set 0.1ml/ physiological saline as a control group at the same time.

As a result：Using percentage Testing index as evaluation criterion.The result shows that after experiment mice feeds 20 days, abdominal cavity macrophage is thin Born of the same parents' phagocytic percentage and phagocytic index are apparently higher than control group；

Embodiment seven

The anxious poison experiment of mouse

1st, experiment material：Kunming mouse, half male and half female, 18-22g；Chinese medicine composition dry extract.

2nd, experimental procedure：

1) trial test：Mouse 24 is taken, is divided into 6 groups with 4 for one group, a series of larger dosage of selection group spacing, respectively Group difference gastric infusion, observes the symptom of appearance and records death toll, find out and cause 0% death rate and 100% death rate dosage Location.

2) formal test：In the range of 0% and 100% lethal dose that trial test is obtained, 5 dosage are selected, it is adjacent Ratio between dosage is 1：0.7.Mouse is grouped at random, every group of 10 mice lavages administration.

3) observation record is to various reactions：In incubation period, intoxicating phenomenon, starts the dead time occur, dead preceding phenomenon, respectively Dead number of elements of group etc..With observation post administration 7 days.According to the death rate of each group animal, with improvement karber's method (Korbor) or simplify Probit method calculates LD50.

3rd, experimental result

The present embodiment selects the Chinese medicine composition dry extract described in embodiment 5, and medication unit is g/kg.d, with improvement bandit Family name's method (Korbor) calculates LD50 values and is all higher than 50g/kg.d.It is classified according to acute toxicity, the true border non-poisonous material of the sample.

Embodiment eight

Analysis of cases

Case 1

Patient Liu, man, age of onset 28 years old, diagnostic result is acute myeloblastic leukemia, and premenstruum (premenstrua) system chemotherapy, is controlled Therapeutic effect is bad, starts to receive Chinese medicine composition of the present invention after 1 year to be treated in diagnosis, through the Chinese medicine course for the treatment of of 6 months Afterwards, remission, but after 6 months, disease has reached clinical cure standard, subsequent after treatment 3 months, and later stage follow-up chases after Track 12 years, patient is not recurred, and has given birth to a son.

Case 2

Patient Min, female, age of onset 11 years old, diagnostic result are acute myeloblastic leukemia, through system chemotherapy 3 months, Therapeutic effect is bad.After start to receive Chinese medicine composition of the present invention to be treated, after the Chinese medicine course for the treatment of of 6 months, disease Alleviate, patient's hemopoietic system starts to recover；Again after 6 months, disease has reached clinical cure standard, subsequent after treatment 3 A month, later stage follow-up was followed the trail of 3 years, and patient is not recurred.

Case 3

Patient Xu certain, man, age of onset 50 years old, diagnostic result is acute myeloid leukemia, through system chemotherapy 3 months, is controlled Therapeutic effect is bad.After start to receive Chinese medicine composition of the present invention to be treated, after the Chinese medicine course for the treatment of of 6 months, disease is delayed Solution, patient's hemopoietic system start to recover；Again after 6 months, disease has reached clinical cure standard, subsequent after treatment 3 Month, later stage follow-up is followed the trail of 3 years, and patient is not recurred.

Case 4

Patient poplar, female, age of onset 72 years old, diagnostic result are chronic myelocytic leukemia, through primary chemotherapy 15 days, are suffered from Person can not be resistant to, and therapeutic effect is bad.After start to receive Chinese medicine composition of the present invention to be treated, through the Chinese medicine of 15 months After the course for the treatment of, patient has reached clinical cure standard, and later stage follow-up is followed the trail of 4 years, and patient is not recurred.

Case 5

Patient ten thousand certain, female, age of onset 12 years old, diagnostic result is alpastic anemia, through systematic treating 6 months, is controlled Therapeutic effect is bad.After start to receive Chinese medicine composition of the present invention to be treated, after the Chinese medicine course for the treatment of of 12 months, Huan Zheyi Reach clinical cure standard, later stage follow-up is followed the trail of 18 years, and patient is not recurred, and has given birth to two sons.

Embodiment nine

Clinical observation

Inclusive criteria：It is acute progranulocyte according to FAB criteria for classifications selection clinical treatment and observation case 20 Leukaemia (man 12, female 8, age 9-72 Sui), and received chemotherapy, unsatisfactory curative effect.

Treatment method：It is oral, 3 times a day, each 5g.Every 1 month as a treatment course, and total course for the treatment of is 15 months.

Observation index：Peripheral hemogram (leucocyte and its classification, blood platelet, hemoglobin)；Bone marrow cytomorphologic examination and its Classification；Clinical symptoms and sign.

Efficacy evaluation：According to the unified the standard of curative effect evaluation in the whole nation, therapeutic evaluation is carried out for clinical treatment leukaemic.

As a result：16 complete incidence graphs of acute promyelocytic leukemic patient, 4 parts are alleviated.Respectively at 1,3,5 year carry out with Visit, all patients are not recurred.

It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair The limitation of the present invention, protection scope of the present invention should be subject to claim limited range.For the art For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change Protection scope of the present invention is also should be regarded as into retouching.

Claims

A kind of 1. Chinese medicine composition for being used to treat Malignant hematologic diseases, it is characterised in that in terms of parts by weight, including under State component：
2. Chinese medicine composition according to claim 1, it is characterised in that in terms of parts by weight, including following components：
3. Chinese medicine composition according to claim 2, it is characterised in that in terms of parts by weight, including following components：
4. Chinese medicine composition according to claim 1 and preparation made of pharmaceutically acceptable auxiliary material.
5. preparation according to claim 4, it is characterised in that the preparation is pill, granule, capsule, oral liquid Middle one or more.
6. the Chinese medicine composition described in claim 5, it is characterised in that the preparation is granule.
7. any one of any one of the claim 1-3 compositions or claim 4-6 preparation is disliked in treatment hematological system Application in property disease.
8. application according to claim 7, it is characterised in that the hematologic malignancy includes leukaemia and regeneration Aplastic anemia.
9. application according to claim 8, it is characterised in that the leukaemia includes acute leukemia and chronic white blood Disease.
10. application according to claim 9, it is characterised in that the acute leukemia includes acute myeloblastic leukemia With acute myeloid leukemia.