CN101120977A - Medicine for treating tumor - Google Patents
Medicine for treating tumor Download PDFInfo
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- CN101120977A CN101120977A CNA2006101096045A CN200610109604A CN101120977A CN 101120977 A CN101120977 A CN 101120977A CN A2006101096045 A CNA2006101096045 A CN A2006101096045A CN 200610109604 A CN200610109604 A CN 200610109604A CN 101120977 A CN101120977 A CN 101120977A
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Abstract
The present invention discloses a new anti tumor medicine, the raw material, which comprises the ganoderma, the spore powder, the kudzuvine root, the Gold Theragran, the glossy privet fruit, the agrimoniae, the sun-plant, the dandelion, the akebiae, the hoelen, the bupleuri, the brunellae cum fructu and the rhubarb. According to the Chinese medicine formulation and different feature of the Chinese herb medicine, with the combination of traditional art and the present art, required preparation type is prepared by conventional method after strict selection, soaking, extraction, alcohol sinking, concentration and preparation. The present invention is prepared by natural herbs, which has a low side effect and toxic effect to human body and serves as a significant effect in tumor treatment.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of tumor, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, belongs to the field of Chinese medicines.
Background technology
Tumor is a class commonly encountered diseases of serious threat human health.In China, tumor (cancer) becomes behind cardiovascular and cerebrovascular disease and murderous second largest disease.Tumor is not a kind of disease but multiple disease is concurrent, as follows ascites, pain and because of chemotherapy causes various side effect etc., and the infiltration of tumor and transfer, multiple medicines and drug resistance are the difficult problems in the current tumor therapeutic procedure.
At present, both at home and abroad to tumor treatment, mainly contain following stubborn problem and exist:
1, excision mainly is that transfer and the infiltration that stops tumor cell lacked effective method.
2, radiotherapy exists identical problem with operative treatment.
3, chemotherapy mainly is the poor selectivity of medicine, to Normocellular toxicity, injury effect and the side reaction that causes.Early stage is respond well, and the later stage produces the effect extreme difference behind multiple medicines and the drug resistance, easily causes the immune reaction of human body self, is unfavorable for patient's survival state.
4, immunotherapy, at present mostly plant amedica is based on immunotherapy, but human immune system's complexity, the human immune system lacked research and the diversity of the body of being correlated with, DeGrain.
At present, the Chinese patent medicine of a lot of treatment tumors is arranged on the market, but effect is all not obvious, the patient still has to rely on the big Western medicine of some side effect and treats cancer.
Summary of the invention
The object of the present invention is to provide a kind of, medicine of suppressing tumor effect obvious treatment tumor little to the human body toxic and side effects.
The present invention also provides the method for preparing said medicine.
Solution of the present invention is based on motherland's medical science to tumor and pathogenetic understanding of complication and Therapeutic Principle, at the morbific factor of human five internal organs's six internal organs, by the theory of Chinese medical science prescription, prescription medicine of the present invention is all from traditional natural plant crude drugs, and is little to the toxic and side effects of human body.
For reaching above-mentioned purpose, the invention provides a kind of medicine for the treatment of tumor, it is characterized in that it is the medicament of being made by following raw materials by weight proportions:
Ganoderma 18～45 spore powders 6～25 Radix Puerariaes 20～35 Radix Rhodiolaes 1 8～38
Fructus Ligustri Lucidi 20～43 Herba Agrimoniaes 18～45 Herba Portulacae Grandifloraes 20～45 Herba Taraxacis 16～32
Fructus Akebiae 8～25 Poria 6～20 Radix Bupleuri 12～30 Spica Prunellaes 6～25
Radix Et Rhizoma Rhei 6～25
The present invention further provides a kind of medicine for the treatment of tumor, it is characterized in that it is the medicament of being made by following raw materials by weight proportions:
Ganoderma 22～38 spore powders 8～20 Radix Puerariaes 22～33 Radix Rhodiolaes 20～35
Fructus Ligustri Lucidi 25～38 Herba Agrimoniaes 22～33 Herba Portulacae Grandifloraes 22～38 Herba Taraxacis 18～25
Fructus Akebiae 8～20 Poria 8～15 Radix Bupleuri 15～25 Spica Prunellaes 8～18
Radix Et Rhizoma Rhei 6～20
The present invention further provides a kind of medicine for the treatment of tumor, it is characterized in that it is the medicament of being made by following raw materials by weight proportions:
Ganoderma 35 spore powders 13 Radix Puerariaes 25 Radix Rhodiolaes 30
Fructus Ligustri Lucidi 30 Herba Agrimoniaes 25 Herba Portulacae Grandifloraes 35 Herba Taraxacis 22
Fructus Akebiae 12 Poria 13 Radix Bupleuri 17 Spica Prunellaes 13
Radix Et Rhizoma Rhei 8
Above-mentioned each component is made the medicine production method that the present invention treats tumor is:
1), take by weighing spore powder in above-mentioned weight portion ratio, behind super micron mill 1000 order breaking cellular walls, the edible ethanol with 65～70% is warmed to 75～80 ℃ and extracted 3 hours, filter, filtrate, standby;
2), take by weighing Fructus Ligustri Lucidi and Radix Rhodiolae in above-mentioned weight portion ratio, the edible steeping in wine bubble with 65～75% three months filters, filtrate, standby;
3), take by weighing remaining ten kinds of crude drug in above-mentioned weight portion ratio, mix after rinsing, use purified water extraction in the Chinese medicine extraction production line, extracting method is as follows:
A) extract the first time, add six times of amount purified water, 80～85 ℃ were extracted 3 hours, and 100 eye mesh screens filter, and get filtrate;
B) extract for the second time, add four times of amount purified water and extracted 2 hours for 75～80 ℃, 100 eye mesh screens filter, get filtrate, merge the filtrate of extracted twice, be condensed into thick paste, add the edible ethanol of equimultiple 95～100%, stir evenly precipitate with ethanol, leave standstill more than 12 hours, supernatant liquid is got in layering, fine straining, get filtrate, standby;
4), merge 1,2,3 filtrate, filtrate decompression and concentrate and remove ethanol, be condensed into thick paste, stored refrigerated is stand-by.
Medicine of the present invention can utilize the conventional formulation production method as required, and needed conventional adjuvant when preparing different dosage form by adding in the thick paste that makes can be made any needed dosage form.
Important characteristic of the medicine of treatment tumor of the present invention is to be rich in abundant Polyphenols in this medicament, total flavonoid (as flavone, isoflavone, flavonol, isoflavone alcohol, flavanone, isoflavanone, chalcone derivative), and polysaccharide, the triterpenes Ganodenic acid chemical compounds such as (tetracyclic triterpenes, pentacyclic triterpenes) of immunomodulating class, wherein some chemical compound has the function of kill cancer cell; Some chemical compound has the effect that reverses to normal cell to human liver cancer cell, adenocarcinoma of stomach cell and lung adenocarcinoma cell; Some chemical compound can improve immunity rapidly, and the phagocytic activity of raising macrophage, NK cell, T cell and lethality are with the kill tumor cell; Some chemical compound can impel a large amount of gamma interferon and the α-Zhong Liuhuaisiyinzis of body secretion, makes the cancerous cell natural apoptosis.Product of the present invention also contains abundant adenosine diphosphate (ADP), though it does not have the ability of anticancer, the fissional effect of adjusting is arranged, and with the Crataegolic acid synergism, can make unusual cancerous cell division trend normal.
The medicine that the present invention treats tumor is little to the human body toxic and side effects, the inhibition tumor effect is obvious.
In order to understand the present invention better, technical scheme of the present invention is described further below in conjunction with embodiment and experiment.
The specific embodiment
Embodiment 1: the medicine of the present invention of preparation granule dosage form
Press column weight amount proportioning (kilogram) and take by weighing crude drug of the present invention:
Ganoderma 18 spore powders 6 Radix Puerariaes 20 Radix Rhodiolaes 18
Fructus Ligustri Lucidi 20 Herba Agrimoniaes 18 Herba Portulacae Grandifloraes 20 Herba Taraxacis 16
Fructus Akebiae 8 Poria 6 Radix Bupleuri 12 Spica Prunellaes 6
Radix Et Rhizoma Rhei 6
1, spore powder with super micron mill 1000 order breaking cellular walls after, the edible ethanol with 65% is warmed to 75 ℃ and extracted 3 hours, filter, filtrate, standby;
2, with 65% alcohol-pickled Fructus Ligustri Lucidi and Radix Rhodiolae three months, filter, filtrate, standby;
3, remaining ten kinds of crude drug of rinsing mix them, use purified water extraction in the Chinese medicine extraction production line, and extracting method is as follows:
A) extract the first time, add six times of amount purified water, 80 ℃ were extracted 3 hours, and 100 eye mesh screens filter, and get filtrate.
B) extract for the second time, add four times of amount purified water and extracted 2 hours for 80 ℃, 100 eye mesh screens filter, get filtrate, merge the filtrate of extracted twice, be condensed into the thick paste of proportion 1.05, add the ethanol of equimultiple 95%, stir evenly precipitate with ethanol, leave standstill more than 12 hours, supernatant liquid is got in layering, fine straining, get filtrate, standby.
4, merge 1,2,3 the concentrated ethanol of removing of filtrate, filtrate decompression, be condensed into the thick paste of proportion 1.15, stored refrigerated is stand-by.
5, according to a conventional method above-mentioned thick paste is mixed with the magma of desired concn, makes the granule dosage form with spray drying method, granule adopts the radiation sterilization sterilization, is distributed into the 4g/ bag, and every bag contains thick paste 0.8g.
Embodiment 2: the medicine of the present invention of preparation oral liquid type
Press column weight amount proportioning (kilogram) and take by weighing crude drug of the present invention:
Ganoderma 45 spore powders 25 Radix Puerariaes 35 Radix Rhodiolaes 38
Fructus Ligustri Lucidi 43 Herba Agrimoniaes 45 Herba Portulacae Grandifloraes 45 Herba Taraxacis 32
Fructus Akebiae 25 Poria 20 Radix Bupleuri 30 Spica Prunellaes 25
Radix Et Rhizoma Rhei 25,
1, spore powder with super micron mill 1000 order breaking cellular walls after, the edible ethanol with 70% is warmed to 75 ℃ and extracted 3 hours, filter, filtrate, standby;
2, with 70% alcohol-pickled Fructus Ligustri Lucidi and Radix Rhodiolae three months, filter, filtrate, standby;
3, remaining ten kinds of crude drug of rinsing mix them, use purified water extraction in the Chinese medicine extraction production line, and extracting method is as follows:
A) extract the first time, add six times of amount purified water, 85 ℃ were extracted 3 hours, and 100 eye mesh screens filter, and get filtrate.
B) extract for the second time, add four times of amount purified water and extracted 2 hours for 80 ℃, 100 eye mesh screens filter, get filtrate, merge the filtrate of extracted twice, be condensed into the thick paste of proportion 1.06, add the ethanol of equimultiple 100%, stir evenly precipitate with ethanol, leave standstill more than 12 hours, supernatant liquid is got in layering, fine straining, get filtrate, standby;
4, merge 1,2,3 the concentrated ethanol of removing of filtrate, filtrate decompression, be condensed into the thick paste of proportion 1.15, stored refrigerated is stand-by;
5, with conventional method above-mentioned thick paste is mixed with the magma of desired concn, filtration, homogenize, with 115 ℃ of autoclavings, sterilization, embeddings in 20 minutes become the oral liquid of one bottle of 30ml, and every bottle contains thick paste 5g.
Embodiment 3: the medicine of the present invention of preparation tablet form
Press column weight amount proportioning (kilogram) and take by weighing crude drug of the present invention:
Ganoderma 35 spore powders 13 Radix Puerariaes 25 Radix Rhodiolaes 30
Fructus Ligustri Lucidi 30 Herba Agrimoniaes 25 Herba Portulacae Grandifloraes 35 Herba Taraxacis 22
Fructus Akebiae 12 Poria 13 Radix Bupleuri 17 Spica Prunellaes 13
Radix Et Rhizoma Rhei 8
1, spore powder with super micron mill 1000 order breaking cellular walls after, the edible ethanol with 70% is warmed to 75 ℃ and extracted 3 hours, filter, filtrate, standby;
2, with 65% alcohol-pickled Fructus Ligustri Lucidi and Radix Rhodiolae three months, filter, filtrate, standby;
3, remaining ten kinds of crude drug of rinsing mix them, use purified water extraction in the Chinese medicine extraction production line, and extracting method is as follows:
A) extract the first time, add six times of amount purified water, 80 ℃ were extracted 3 hours, and 100 eye mesh screens filter, and get filtrate.
B) extract for the second time, add four times of amount purified water and extracted 2 hours for 80 ℃, 100 eye mesh screens filter, get filtrate, merge the filtrate of extracted twice, be condensed into the thick paste of proportion 1.07, add the ethanol of equimultiple 95%, stir evenly precipitate with ethanol, leave standstill more than 12 hours, supernatant liquid is got in layering, fine straining, get filtrate, standby;
4, merge 1,2,3 the concentrated ethanol of removing of filtrate, filtrate decompression, be condensed into the thick paste of proportion 1.15, stored refrigerated is stand-by;
5, according to a conventional method above-mentioned thick paste being mixed with the magma of desired concn, is the tablet form of 4g/ sheet with the mixture tabletting, and granule adopts the radiation sterilization sterilization, and every granule contains thick paste 0.8g.
Can utilize the conventional preparation method of the field of Chinese medicines, the thick paste that crude drug of the present invention makes is made needed any dosage form as required.Do not exceed with the foregoing description.
The above-mentioned clinical drug of the present invention that makes uses the result to show that following advantage is arranged.
1, crude drug of the present invention is selected for use from traditional natural plant, can find the regulation that meets pharmaceutical control and administration in state-promulgated pharmacopoeia and provincial standard, and adjuvant only is starch and purified water, and is little to the human body toxic and side effects, can suppress tumor effectively.
2, technology of the present invention is with modern crafts production plant amedica, the dosage form taking convenience, and raw material and adjuvant clothes close national every regulation.
3, the tumor killing effect of product of the present invention is obvious, in National Key Laboratory--the checking of-Guangdong Zhongshan Univ. Cancer Cure Center shows: Heps hepatocarcinoma in the mice body and S180 sarcoma are had obvious inhibitory action, can reach 78% to the S180 tumour inhibiting rate, the fourth phase tests up to 83%.
3, show through clinic trial, product of the present invention all has tangible effect to intestines and stomach tumor (carcinoma of gallbladder, cancer of pancreas, rectal cancer, hepatocarcinoma etc.), thoracic cavity tumor, tumor of head and neck, mammary neoplasms, urinary tract tumor, and statistics find 92% patient take granule after leukocyte be raised to normal level, 89% patient obviously eliminates ascites in 3-7 days after taking, eliminate the chemotherapy evil legacy, and obviously change cachexia.
Experiment and clinical observation result
1, the statistical result of clinical observation
For showing medicine of the present invention to the tumor treatment effect, product of the present invention is through 103 routine clinical observations, and all to be diagnosed as cancer, the patient man is 65 examples, women 38 examples, age 20-30 year 2 examples, 30-40 year 1 example, 40-50 year 32 examples, 50-60 year 27 examples.60 years old last 41 examples, 55.2 years old mean age, most of patient carried out chemotherapy and doctor trained in Western medicine is made a definite diagnosis and the product of the present invention of changing the place of examination, thereby includes the test case in.
Diagnostic criteria: " the Chinese common cancer diagnosis and treatment standard " criterion of therapeutical effect with reference to Ministry of Public Health Department of Medical Administration song cloth is divided into (1) cancer criterion of therapeutical effect.Alleviate fully: cancer disappears and continues more than 1 month.Part is alleviated: the orthogonal diameter product of 2 maximums of cancer dwindles more than 50%, and continues more than 1 month.Stable: the orthogonal diameter product of 2 maximums of cancer dwindles less than more than 50%, increases to be no more than 25%, and continues more than 1 month.Worsen: the orthogonal diameter product of 2 maximums of cancer increases above 25%.(2) life quality evaluation criteria.Press the Karnofsky scoring, compare before and after treating.Produce effects: the treatment back increases by 20 fens than treatment is preceding.Effectively: the treatment back increases by 10 fens than treatment is preceding.Invalid: as not reach above standard person.(3) standard determination that pain relief curative effect is issued by World Health Organization (WHO): alleviate fully, promptly do not have pain fully after the treatment; Part is alleviated, and promptly pain obviously alleviates before than administration, and it is unaffected substantially sleep, energy orthobiosis; The slight alleviation, promptly pain alleviates before than administration, but still feels obvious pain, and it is still influenced to sleep; Invalid, promptly with before the treatment relatively do not have and alleviate.
Instructions of taking: the liquid oral dosage form of oral embodiment 2, every day 3 times, take the circumstances into consideration to increase according to the state of an illness.1 month is a course of treatment.
Observation index (1) tumor body changes before the medication and with after wanting a course of treatment, and row liver B ultrasonic or CT examination are determined the focus medication front and back size variation that can clearly measure.(2) quality of life improvement situation record dining every day amount; The pain assessment; Body weight; Sleep and mental status; Kamofsky quality of life marks.(3) safety detects reference white cell, ALT, Y-GT etc.(4) any untoward reaction that occurs during the related reactions record recording medicine
Therapeutic outcome:
Cancer is alleviated 3 examples fully and is accounted for 3%, and part is alleviated 75 examples and accounted for 73%, stablizes 15 examples 14%, worsens 10 examples 10%;
Life quality produce effects 15 examples account for 14%, and effective 69 examples account for 68%, and invalid 19 examples account for 18%;
Total pain relief 5 examples account for 5%, and part is alleviated 72 examples and accounted for 70%, slightly alleviates 18 examples 17%, invalid 8 examples 8%; In the clinical trial process, do not see untoward reaction and side effect.
2, the function of tumor inhibition of medicine of the present invention reaches the influence to tumor-bearing mice liver, renal function, hemogram
1) materials and methods:
(1) material
Laboratory animal is used the NIH mice, is provided by Department of Health of Guangdong Province's Experimental Animal Center.The laboratory animal environmental facility and the zoopery environmental facility quality certification number are respectively 26-2003B001 and 26-2003C001 (economizing the meeting of the moving pipe of medical experiment).Mice body weight 18-22g, male and female half and half.(Sarcoma-180 S-180) is provided by Zhongshan Univ. Cancer Cure Center for rat liver cancer (Hepatoma) and murine sarcoma-180.The granule that medicine makes for embodiment 1 and available from the cyclophosphamide of Hengrui Medicine Co., Ltd., Jiangsu Prov. (Cyclophosphamide, Endoxan, Cytoxan, CTX).
(2) method
Aseptic condition extracts the abdominal cavity down and protects kind of 7-9 days eugonic transplanted animal tumor rat liver cancer cells, is diluted to 2 * 10 with normal saline
6The Cell sap of/ml, every mice is 0.2ml in right axil subcutaneous vaccination tumor cell liquid, mice is divided into 6 groups at random, 10 every group.Each group is all in inoculation beginning in back 24 hours gastric infusion, continuous 10 days.The 1st group of negative matched group is with water for injection 20mlkg
-1/ d, the 2nd group of positive matched group is with cyclophosphamide 50mgkg
-1/ 1 time, the 3rd group is embodiment 1 groups of grains 4gkg
-1/ d, the 4th group is embodiment 1 groups of grains 8gkg
-1/ d, the 5th group is embodiment 1 groups of grains 16gkg
-1/ d is gastric infusion respectively.Get blood from each group eyeball of mouse in the last administration respectively after 24 hours and do hemogram and hepatic and renal function detection and put to death mice, claim Mus heavy, peel off tumor and claim tumor heavy, the calculating tumour inhibiting rate.Formula is as follows: the difference between tumour inhibiting rate (%)={ 1-(the average tumor of the average tumor weight/negative control group of administration group is heavy) } * 100% usefulness t check determination experiment group and the matched group.
2) result
(1) embodiment 1 granule is to the inhibitory action of rat liver cancer:
In twice experiment, each is organized suppression ratio and is respectively: CTX group tumour inhibiting rate is 70.3%-75.9%, and embodiment 1 groups of grains low dose group is 52.5-60.2%, and the dosage group is 50.8-61.3% in embodiment 1 groups of grains, and high dose group is 70.8-75.0%.The tumor-inhibiting action of each group and negative control group compare, and all there were significant differences (all P＜0.0001) through the t check.In pressing down the tumor experimentation, it is movable active that each organizes mice, and hair color is glossy, do not see depilation is arranged, situations such as Folium Pini (except that the cyclophosphamide group), diarrhoea.
(2) embodiment 1 granule is to the inhibitory action of S-180
In twice experiment, each is organized suppression ratio and is respectively: CTX group tumour inhibiting rate is 71.5%-73.1%, and embodiment 1 groups of grains low dose group is 53.3-56.9%, and the dosage group is 50.3-58.8% in embodiment 1 groups of grains, and high dose group is 73.1-78.2%.The tumor-inhibiting action of each group and negative control group compare, and all there were significant differences (all P＜0.0001) through the t check.
(3) embodiment 1 granule is to the influence of Mouse Liver, renal function
Hepatic and renal function testing result: embodiment 1 granule is to glutamate pyruvate transaminase (GPT), glutamic oxaloacetic transaminase, GOT (GOT) in the tumor-bearing mice blood, and a good appetite suddenly appearing in a serious disease dosage group GPT has outside the obvious reduction, and all the other each groups compare there was no significant difference (P＞0.05) with negative control group.Blood urea nitrogen (BUN), uric acid (UA), creatinine (CRE), except that the low dosage creatinine content had obvious rising, all the other each groups compared there was no significant difference (P＞0.05) with matched group.
(4) embodiment 1 granule is to the influence of tumor-bearing mice hemogram
The hemogram testing result: leukocyte (WBC), erythrocyte (RBC), hemoglobin (HGB), platelet (PLT), except that low dose group WBC average has the obvious reduction, all the other each groups compare there was no significant difference (P＞0.05) with matched group.
3) conclusion
(1) embodiment 1 granule all has the obvious suppression effect to rat liver cancer and S-180.In experimentation, each is organized, and mice is movable active, and hair color is glossy, do not see depilation is arranged, situations such as Folium Pini and diarrhoea.
(2) embodiment 1 granule has the obvious reduction except that the low dose group creatinine content has obvious rising and middle dosage group GPT the influence of tumor-bearing mice liver, renal function, and all the other dosage groups all do not have obvious influence.
(3) embodiment 1 granule is to the influence of tumor-bearing mice hemogram, and except that low dose group WBC average has the obvious reduction, all the other each dosage groups all do not have obvious influence.
Claims (6)
1. medicine for the treatment of tumor is characterized in that it is the medicament of being made by following raw materials by weight proportions:
Ganoderma 18～45 spore powders 6～25 Radix Puerariaes 20～35 Radix Rhodiolaes 18～38
Fructus Ligustri Lucidi 20～43 Herba Agrimoniaes 18～45 Herba Portulacae Grandifloraes 20～45 Herba Taraxacis 16～32
Fructus Akebiae 8～25 Poria 6～20 Radix Bupleuri 12～30 Spica Prunellaes 6～25
Radix Et Rhizoma Rhei 6～25.
2. a kind of medicine for the treatment of tumor as claimed in claim 1 is characterized in that it is the medicament of being made by following raw materials by weight proportions:
Ganoderma 22～38 spore powders 8～20 Radix Puerariaes 22～33 Radix Rhodiolaes 20～35
Fructus Ligustri Lucidi 25～38 Herba Agrimoniaes 22～33 Herba Portulacae Grandifloraes 22～38 Herba Taraxacis 18～25
Fructus Akebiae 8～20 Poria 8～15 Radix Bupleuri 15～25 Spica Prunellaes 8～18
Radix Et Rhizoma Rhei 6～20.
3. a kind of medicine for the treatment of tumor as claimed in claim 1 is characterized in that it is the medicament of being made by following raw materials by weight proportions:
Ganoderma 35 spore powders 13 Radix Puerariaes 25 Radix Rhodiolaes 30
Fructus Ligustri Lucidi 30 Herba Agrimoniaes 25 Herba Portulacae Grandifloraes 35 Herba Taraxacis 22
Fructus Akebiae 12 Poria 13 Radix Bupleuri 17 Spica Prunellaes 13
Radix Et Rhizoma Rhei 8.
4. as claim 1,2 or 3 described medicines, it is characterized in that said medicament is a said dosage form on any pharmaceutics.
5. as claim 1,2 or 3 described medicines, it is characterized in that said medicament is granule, oral liquid or tablet.
6. one kind prepares claim 1,2 or 3 one kind of preparation method for the treatment of the medicine of tumor, and it comprises the following steps:
1), take by weighing spore powder in above-mentioned weight portion ratio, behind super micron mill 1000 order breaking cellular walls, the edible ethanol with 65～70% is warmed to 75～80 ℃ and extracted 3 hours, filter, filtrate, standby;
2), take by weighing Fructus Ligustri Lucidi and Radix Rhodiolae in above-mentioned weight portion ratio, the edible steeping in wine bubble with 65～75% three months filters, filtrate, standby;
3), take by weighing remaining ten kinds of crude drug in above-mentioned weight portion ratio, mix after rinsing, use purified water extraction in the Chinese medicine extraction production line, extracting method is as follows:
A) extract the first time, add six times of amount purified water, 80～85 ℃ were extracted 3 hours, and 100 eye mesh screens filter, and get filtrate.
B) extract for the second time, add four times of amount purified water and extracted 2 hours for 75～80 ℃, 100 eye mesh screens filter, get filtrate, merge the filtrate of extracted twice, be condensed into thick paste, add the edible ethanol of equimultiple 95～100%, stir evenly precipitate with ethanol, leave standstill more than 12 hours, supernatant liquid is got in layering, fine straining, get filtrate, standby;
4), merge 1,2,3 filtrate, filtrate decompression and concentrate and remove ethanol, be condensed into thick paste, stored refrigerated is stand-by.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772523A (en) * | 2012-08-09 | 2012-11-14 | 谢瑜 | Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition |
| CN103040893A (en) * | 2013-01-23 | 2013-04-17 | 崔合芳 | Pharmaceutical composition for treating liver cancers and preparation method thereof |
| CN109381575A (en) * | 2018-11-19 | 2019-02-26 | 厦门妙九科技开发有限公司 | A kind of Chinese medicine that can significantly reduce PD-L1 expression |
| CN110624027A (en) * | 2019-07-20 | 2019-12-31 | 徐晓萍 | Anti-tumor traditional Chinese medicine composition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN1485083A (en) * | 2003-06-13 | 2004-03-31 | 许新琳 | Capsule for thyroid cancer / tumor and lymph node |
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2006
- 2006-08-09 CN CN200610109604A patent/CN101120977B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772523A (en) * | 2012-08-09 | 2012-11-14 | 谢瑜 | Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition |
| CN102772523B (en) * | 2012-08-09 | 2014-11-19 | 谢瑜 | Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition |
| CN103040893A (en) * | 2013-01-23 | 2013-04-17 | 崔合芳 | Pharmaceutical composition for treating liver cancers and preparation method thereof |
| CN109381575A (en) * | 2018-11-19 | 2019-02-26 | 厦门妙九科技开发有限公司 | A kind of Chinese medicine that can significantly reduce PD-L1 expression |
| CN110624027A (en) * | 2019-07-20 | 2019-12-31 | 徐晓萍 | Anti-tumor traditional Chinese medicine composition |
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| CN101120977B (en) | 2010-05-26 |
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