CN101664541B - Medicament for treating dysmenorrhoea and preparation method thereof - Google Patents
Medicament for treating dysmenorrhoea and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medicament for treating dysmenorrhoea and a preparation method thereof. The medicament comprises the following raw materials in portion by weight: 10 to 25 portions of evodia fruit, 10 to 25 portions of cassia twig, 8 to 20 portions of Chinese angelica, 8 to 20 portions of Szechuan lovage rhizome, 8 to 20 portions of corydalis root, 4 to 10 portions of dried ginger, 4 to 10 portions of pinellia rhizome, 5 to 15 portions of white paeony root, and 1 to 2.5 portions of liquorice root. The preparation method comprises the following steps: extracting the cassia twig, the evodia fruit, the Chinese angelica, the Szechuan lovage rhizome and the corydalis root by using ethanol, and concentrating the ethanol extract to form an extract; extracting the dried ginger, the pinellia rhizome, the white paeony root and the liquorice root by using water, and concentrating the water extract to form an extract; and combining the two extracts, vacuum-drying the combined extracts, crushing the extracts and then adding proper amount of accessories into the extracts, and evenly mixing and pelletizing the mixture. The medicament has obvious inhibition or treatment effect on the dysmenorrhoea caused by wading cold in the rain at the menstrual period, or eating raw or cold food, cold-dampness uterus weakness and menses stagnation, and has obvious analgesia and anti-inflammatory effects at the same time.
Description
Technical field
The invention belongs to the new Chinese medicine technical field, be specifically related to a kind of pharmaceutical composition for the treatment of the dysmenorrhea disease and preparation method thereof.
Technical background
Dysmenorrhea, traditional medicine also claim " dysmenorrhea " to have another name called " menstrual abdominalgia ", " abdominal pain during menstruation ", " abdominal pain in menstruation ", " dysmenorrhoea " etc.Chinese medicine is to the treatment of dysmenorrhea, and curative effect is by clinical confirmation.The traditional Chinese medical science thinks, primary dysmenorrhea mainly is because the women between menstrual period, is subject to the impact of paathogenic factor, causes punching to appoint strongly fragrant resistance or a cold accumulating in meridian, makes QI-blood circulation not smooth, and consequently " stagnation of QI and blood may bring about pain " is obstructed in the circulation of uterus menses; Or punching is appointed, uterus lose in moistening foster, Rong Ze pain.
In view of primary disease shows effect repeatedly, every monthlyly be subjected to ailing the torment, therefore misery is felt in patient's life, work very much, if delay is with the passing of time, may cause the nullipara can not be conceived, therefore, to the treatment of primary disease, become one of important topic of Chinese medicine and pharmacy worker research.
29 provinces and cities' survey results of China, dysmenorrhea incidence rate 33.19%, wherein primary dysmenorrhea 30.06%, and is slight 45.73%, moderate 38.81%, severe 13.55%, Andersch etc. are in the investigation of not producing the women in 19 years old, and dysmenorrhea accounts for 72.4% (420 example), and severe pain is through accounting for 15.4% (90 example), affect orthobiosis and work, and invalid to analgesic.It is rarely found that former sore warp occured within menophania later six months, it is reported that 13% occurs in the Second Year in 75% former sore after occurring in menophania 1 year, and 50% in the 3rd year.Secondary dysmenorrhea often occurred in menophania after 2 years, and age, the course of disease of various disease dysmenorrhea differ, and the morning and evening that dysmenorrhea occurs is also different.
The sheet that relieves the pain is a lot of dysmenorrhea women's first-selection, but fully by eat tablet for alleviating pain ease pain be serious mistake and special wrong, tablet for alleviating pain has very large injury to people's stomach, liver, for the intestines and stomach and the bad women of liver, takes tablet for alleviating pain even understands life threatening.
Some compound Chinese medicinal preparation treatment dysmenorrhea diseases are also arranged at present clinical, although certain curative effect is arranged, dose is larger.For example WENJING WAN is aided with the Ten Herbs such as the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Cortex Cinnamomi and forms take Radix Codonopsis as monarch drug.Its production technology is that 11 kinds of compositions are ground into fine powder, adds the pill that refined honey is made the 9g/ ball.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of dysmenorrhea, for the characteristics of dysmenorrhea (cold blood stasis type) clinically, with dispelling cold by warming the meridian, dehumidifying is regulated the flow of vital energy, and promoting blood circulation and stopping pain is the rule for the treatment of, selects suitable Chinese medicine jointly to form compound recipe on basis, warming the meridian side;
Another object of the present invention is to provide a kind of preparation method for the treatment of the pharmaceutical composition of dysmenorrhea, in production process, adopt different extracting method, extract most possibly the effective ingredient of each flavour of a drug.
Medicine of the present invention is comprised of the raw medicinal material of following portions by weight ratio: 10～25 parts of Fructus Evodiaes, 10～25 parts of Ramulus Cinnamomi, 8～20 parts of Radix Angelicae Sinensis, 8～20 parts of Rhizoma Chuanxiongs, 8～20 parts of Rhizoma Corydalis, 4～10 parts of Rhizoma Zingiberiss, 4～10 parts of Rhizoma Pinelliae Preparatum, 5～15 parts of the Radix Paeoniae Albas; 1～2.5 part in Radix Glycyrrhizae.
Medicine optimum feed stock weight proportion of the present invention is: 18 parts of Fructus Evodiaes; 18 parts of Ramulus Cinnamomi; 14.4 parts of Radix Angelicae Sinensis; 14.4 parts of Rhizoma Chuanxiongs; 14.4 parts of Rhizoma Corydalis; 7.2 parts of Rhizoma Zingiberiss, 7.2 parts of Rhizoma Pinelliae Preparatum, 9 parts of the Radix Paeoniae Albas, 1.8 parts in Radix Glycyrrhizae.
The preparation method of medicine of the present invention is:
A, get the raw materials ready: take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption, each Chinese crude drug is cleaned dried, for subsequent use
B, ethanol extraction: Ramulus Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis are added the alcohol reflux three times that 4-8 doubly measures 30-80%, then filter, the extractum of relative density 1.10-1.30 with filtrate recycling ethanol and when being concentrated into 50 degrees centigrade;
C, water extraction: with Rhizoma Zingiberis, Rhizoma Pinelliae Preparatum, the Radix Paeoniae Alba, Radix Glycyrrhizae, decoct with water three times, each amount of water is 5-10 times, filters the extractum of relative density 1.10-1.30 when filtrate is concentrated into 50 degrees centigrade;
D, combination drying: with two kinds of extractum mixings of gained among step b and the step c, in 50-80 degree centigrade of drying under reduced pressure, add the appropriate amount of auxiliary materials mixed pelletization after pulverizing.
The dosage form of the pharmaceutical composition finished product preparation for the treatment of dysmenorrhea disease of the present invention is acceptable any dosage form of routine techniques method preparation on the pharmaceutics, such as granule, pill, capsule, soft capsule, tablet, mixture, oral liquid etc.
Medicine of the present invention is oral medicine, and consumption is a 10g, 3 times on the one.
Technical scheme of the present invention is based on motherland's medical science to the pathogenetic understanding of dysmenorrhea and Therapeutic Principle, with reference to modern pharmacological research achievement, according to dispelling cold by warming the meridian, dehumidifying regulate the flow of vital energy, the principles of formulating prescriptions of promoting blood circulation and stopping pain form.Ramulus Cinnamomi, Fructus Evodiae dispelling cold by warming the meridian in the side, activating YANG and prormoting functioning of QI, the promoting blood circulation of holding concurrently is with pain relieving, and Ramulus Cinnamomi is longer than warm promoting blood circulation, and Fructus Evodiae is longer than promoting the circulation of QI to relieve pain, and two medicines phase 5 is excellent to the dysmenorrhea curative effect of congealing cold with blood stasis, and is monarch drug.Radix Angelicae Sinensis, Rhizoma Chuanxiong nourish blood and blood, and cold relieving and just not hindering is enriched blood and do not stopped up stagnantly, is known as foshousan, is regulating menstruation by adjusting the flow of blood product commonly used; The Rhizoma Corydalis promoting flow of QI and blood, eliminating stasis to stop pain; The Rhizoma Zingiberis dispelling cold by warming the meridian, the sensible part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Rhizoma Pinelliae Preparatum normalizing the stomach by guiding QI downward preventing or arresting vomiting is " patient suffering from habitual vomiting panacea ", 5 Rhizoma Zingiberis pungent drugs can disperse and bitter drugs can descends, and warming middle-JIAO for easing the stomach, the gas of sending down the abnormal ascending QI punching accompanies the vomiter quite to imitate to violent dysmenorrhea.Above five is ministerial drug altogether.The Radix Paeoniae Alba, Radix Glycyrrhizae compatibility are peony and licorice decoction, are the recipe of relieving spasm to stop pain, and spasm stomachache is truly had good effect.The all medicines of compatibility in full side, the dispelling cold by warming the meridian of building together, the dehumidifying of regulating the flow of vital energy, the merit of promoting blood circulation and stopping pain, and be adjuvant.Full side makes a concerted effort, and plays altogether dispelling cold by warming the meridian, and dehumidifying is regulated the flow of vital energy, the merit of promoting blood circulation and stopping pain.The present invention according to the not same-action of various flavour of a drug, adopts different extracting method on preparation technology, preparation technology's maximum possible extracts the effective ingredient of each flavour of a drug.
Show through pharmacodynamic study, the high, medium and low dosage group of the present invention has significant analgesic activity to the dysmenorrhea mice that oxytocin brings out; Significantly reduce PGE
2(prostaglandin E
2) content, obviously reduce the writhing number of times of dysmenorrhea model rat; The mice internal organs pain that Dichlorodiphenyl Acetate causes has significant inhibitory action; The mice ear that xylol causes has obvious inhibitory action.Show through toxicologic study: the Wistar rat oral gavage, 3 months high, medium and low dosage groups of successive administration and matched group be body weight, dietary amount, water uptake no significant difference relatively, blood routine examination, blood biochemical are learned inspection and are compared no significant difference with matched group, have no obvious untoward reaction.After two weeks of drug withdrawal, each treated animal body weight gain is good, and high, medium and low dosage group and matched group be body weight, dietary amount, water uptake no significant difference relatively, and blood routine examination, blood biochemical are learned and checked and the more equal no significant difference of matched group.Illustrate that the said preparation life-time service is more safe and reliable.
Prove determined curative effect of the present invention through zoopery; Long term toxicity test proves, the present invention is in therapeutic process, taking (3 months) has no side effect substantially, catch a cold for paddling in spite of the rain through front a few days or menstrual period, or voracious raw food, the heresy visitor of cold-damp is in a punching uterus, menses stagnate, cold and pain in the lower abdomen all has obvious inhibition or therapeutical effect through the dim red dysmenorrhea that has piece to cause of color, also has simultaneously obvious analgesia, antiinflammatory action.The present invention is a kind of, and to be used for the treatment of the pharmaceutical composition properties of dysmenorrhea disease safe, quality controllable.
The specific embodiment
Embodiment 1
1, Fructus Evodiae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Zingiberis, Rhizoma Pinelliae Preparatum, the Radix Paeoniae Alba, Radix Glycyrrhizae are cleaned dried, get 100 parts of Fructus Evodiaes, 100 parts of Ramulus Cinnamomi, 80 parts of Radix Angelicae Sinensis, 80 parts of Rhizoma Chuanxiongs, 80 parts of Rhizoma Corydalis, 40 parts of Rhizoma Zingiberiss, 40 parts of Rhizoma Pinelliae Preparatum, 50 parts of the Radix Paeoniae Albas, 10 parts in Radix Glycyrrhizae.
2, ethanol extraction: Ramulus Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis are added the alcohol reflux three times that 4-8 doubly measures 30-80%, then filter, the extractum of relative density 1.10-1.30 with filtrate recycling ethanol and when being concentrated into 50 degrees centigrade;
3, water extraction: with Rhizoma Zingiberis, Rhizoma Pinelliae Preparatum, the Radix Paeoniae Alba, Radix Glycyrrhizae, decoct with water three times, each amount of water is 5-10 times, filters the extractum of relative density 1.10-1.30 when filtrate is concentrated into 50 degrees centigrade;
4, combination drying: with two kinds of extractum mixings of gained among step b and the step c, in 50-80 degree centigrade of drying under reduced pressure, add the appropriate amount of auxiliary materials mixed pelletization, mixing after pulverizing.
Can make tablet, capsule or electuary as required, during the preparation Tablet and Capsula, the adjuvant of adding is generally starch, dextrin or magnesium stearate.During the preparation electuary, the adjuvant of adding is generally sugar and dextrin or other sweeting agents.
Embodiment 2
Fructus Evodiae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Zingiberis, Rhizoma Pinelliae Preparatum, the Radix Paeoniae Alba, Radix Glycyrrhizae cleaned dry, get 250 parts of Fructus Evodiaes, 250 parts of Ramulus Cinnamomi, 200 parts of Radix Angelicae Sinensis, 200 parts of Rhizoma Chuanxiongs, 200 parts of Rhizoma Corydalis, 100 parts of Rhizoma Zingiberiss, 100 parts of Rhizoma Pinelliae Preparatum, 150 parts of the Radix Paeoniae Albas, 25 parts in Radix Glycyrrhizae.
Other step is with embodiment 1.
Embodiment 3
With Fructus Evodiae; Ramulus Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Zingiberis, Rhizoma Pinelliae Preparatum, the Radix Paeoniae Alba, Radix Glycyrrhizae are cleaned and dry, and get 180 parts of Fructus Evodiaes, 180 parts of Ramulus Cinnamomi, 144 parts of Radix Angelicae Sinensis, 144 parts of Rhizoma Chuanxiongs, 144 parts of Rhizoma Corydalis, 72 parts of Rhizoma Zingiberiss, 72 parts of Rhizoma Pinelliae Preparatum, 90 parts of the Radix Paeoniae Albas, 18 parts in Radix Glycyrrhizae.
Other step is with embodiment 1.
Effect experiment
The medicine that the present invention makes, through zoopery, the dysmenorrhea mice that oxytocin is brought out has significant analgesic activity; The mice internal organs pain that Dichlorodiphenyl Acetate causes has significant inhibitory action; The chmice acute inflammation that xylol causes also has significant inhibitory action.
In zoopery, the medicine that the present invention makes is granule, and called after Jiang Gui relaxes through granule, and contrasting tested medicine is TONGJINGBAO KELI, specifically tests as follows:
Tested medicine: Jiang Guishu is the front yellowish-brown powder of granulating through granule, and every gram contains crude drug 3.99 grams, and Science and Technology Ltd. provides by the Jilin great achievement, lot number: 071004, and TONGJINGBAO KELI is as if the western Pharmacy stock Co., Ltd in Henan produces lot number: 070917.The equal gastric infusion of said medicine, matched group give same volume (20ml/kg) water.
Reagent: estradiol benzoate injection, Shanghai General Pharmaceutical Co., ltd., lot number: 050105; Injection Alprostadil (prostaglandin E
1) injection, Ha Gaoke white swan Pharmaceutical Group Co.,Ltd, lot number: 054001; Oxytocin inj, Shanghai Hefeng Pharmaceutical Co., Ltd., lot number: 070703; Dimethylbenzene, organic synthesis chemical plant, Wuhan, lot number: 891009; Carrageenin, Shenyang Pharmaceutical University's department of Chinese materia medica provides; Glacial acetic acid Beijing North fine chemicals Co., Ltd produces, lot number: 20021030; PGE
2Radioimmunoassay kits is provided by Suzhou Medical College thrombosis chamber.
Animal: Kunming mouse, body weight 20～22g; Available from Changchun Biological Products Institute, the quality certification number: SCXK-2002-0001; The Wistar rat, body weight 150～240g, preclinical medicine institute of Jilin University zoopery center provides, quality certification SCXK-(Ji) 2003-0001.
Method and result
One, on the impact of dysmenorrhea model in mice
Get 50 of healthy adult unpregnancy female mices, divide equally at random five groups, be respectively matched group, positive control TONGJINGBAO KELI group (2.6g/kg) and Jiang Guishu through groups of grains (1.6,0.8,0.4g/kg).Each treated animal continuous subcutaneous injection (sc) estradiol benzoate injection, once a day, continuous 8 days, first day and be 4mg/kg on the 8th day, second day to the seven days was 2mg/kg, from injection the 7th day of estradiol benzoate, each is organized gavage and gives tested medicine, successive administration 3 days, and matched group gives the equal-volume distilled water, after the last administration 1 hour, each treated animal lumbar injection (ip) prostaglandin E
112.5 μ g/10g, observed and recorded ip prostaglandin E
1The writhing response number of times that mice occurs in rear 30 minutes.The results are shown in Table 1.
Table 1. Jiang Gui relaxes through the impact of granule on the reaction of dysmenorrhea mice pain
Compare * P＜0.05, * * P＜0.01.x ± S. with model group
The result shows, TONGJINGBAO KELI 1.5g/kg group and Jiang Guishu organize the writhing response number of times that can reduce the dysmenorrhea mice through granule 1.6,0.8,0.4g/kg, relatively have significant difference with matched group.
Two, on the impact of rat dysmenorrhea model
Get 60 of rats, be divided at random six groups, be respectively blank group, model group, positive control drug TONGJINGBAO KELI group (1.8g/kg) and Jiang Guishu through groups of grains (1.1,0.55,0.275g/kg).Except the blank group, all the other respectively organize rat continuous subcutaneous injection estradiol benzoate injection 10 days (subcutaneous injection 0.5mg/ days the 1st and 10 day every day, subcutaneous injection 0.2mg/ days all the other 8 day every days), from injection the 6th day of estradiol benzoate, each is organized gavage and gives tested medicine, successive administration 4 days, matched group gives the equal-volume distilled water, after the last administration 1 hour, each treated animal lumbar injection (ip) oxytocin 2ug/, the writhing response number of times that rat occurs in 30 minutes behind the observed and recorded ip oxytocin, then rat aorta is got blood, blood plasma is got in the EDTA-2Na anticoagulant, according to PGE
2Radioimmunoassay kits detects description and requires to measure PGE
2Content the results are shown in Table 2.
Table 2. Jiang Gui relaxes through the impact of granule on the Dysmenorrhea Rats pain reaction
With matched group relatively: * * P＜0.01*P＜0.05.x ± S.
The result shows, Jiang Guishu significantly reduces PGE through granule 1.1,0.55g/kg and TONGJINGBAO KELI 1.8g/kg
2Content obviously reduces the writhing number of times of dysmenorrhea model rat, and Jiang Guishu is the strongest through the effect of granule 1.1g/kg group.
Three, xylol causes the impact of mice ear
Get 50 of 20g ± 2g mice, be divided at random 5 groups, be respectively matched group (distilled water), positive control drug TONGJINGBAO KELI group (2.6g/kg) and Jiang Guishu through groups of grains (1.6,0.85,0.4g/kg).The gastric infusion of dosage shown in pressing, every day 1 time, continuous 4 days, matched group gave the equal-volume distilled water.Smeared dimethylbenzene 0.1ml/ only in the Mus auris dextra in 1 hour after the last administration, be coated with rear 4h and put to death mice, along the auricle baseline with directly through being that the sharp card punch of 9mm is laid the ears sheet in same area, weigh respectively, calculate its difference as swelling.The results are shown in Table 3.
The relax impact of the mice auricle swelling degree that causes through the granule xylol of table 3. Jiang Gui
Compare * P＜0.05 with matched group
The result shows: TONGJINGBAO KELI 2.6g/kg group and Jiang Guishu have obvious inhibitory action through the mice ear that granule 1.6,0.8g/kg group xylol cause, relatively have significant difference with matched group.
Four, Dichlorodiphenyl Acetate causes the impact of mouse writhing reaction
Get 50 of mices, divide equally at random five groups, be respectively matched group (distilled water), positive control drug TONGJINGBAO KELI group (2.6g/kg) and Jiang Guishu through groups of grains (1.6,0.8,0.4g/kg).Hungry 15h before the administration group mice gastric infusion every day one-time continuous administration 4 days, last administration, 1h respectively organizes mouse peritoneal and only injects 0.8% glacial acetic acid 0.2ml/ after the last administration, and mouse writhing number of times in rear 5 minutes～15 minutes injected in record, the results are shown in Table 4.
Table 4. Jiang Gui relaxes and causes the impact of mice pain reaction through the granule Dichlorodiphenyl Acetate
Compare * P＜0.05 with matched group
The result shows, TONGJINGBAO KELI 2.6g/kg and Jiang Guishu have obvious inhibitory action through the mouse writhing reaction that granule 1.6,0.8g/kg Dichlorodiphenyl Acetate cause.
Claims (3)
1. medicine for the treatment of dysmenorrhea is characterized in that: mixed by the hot water extract of the ethanol extraction of Fructus Evodiae 10～25 weight portions, Ramulus Cinnamomi 10～25 weight portions, Radix Angelicae Sinensis 8～20 weight portions, Rhizoma Chuanxiong 8～20 weight portions, Rhizoma Corydalis 8～20 weight portions and Rhizoma Zingiberis 4～10 weight portions, Rhizoma Pinelliae Preparatum 4～10 weight portions, the Radix Paeoniae Alba 5～15 weight portions, Radix Glycyrrhizae 1～2.5 weight portion and form;
Ethanol extraction wherein is the alcohol reflux three times that the Ramulus Cinnamomi got, Fructus Evodiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis add 4-8 times of weight 30-80%, then filter, with filtrate recycling ethanol and the extractum that relative density 1.10-1.30 obtains when being concentrated into 50 degrees centigrade;
Hot water extract wherein is Rhizoma Zingiberis, Rhizoma Pinelliae Preparatum, the Radix Paeoniae Alba, the Radix Glycyrrhizae of getting, and decocts with water three times, and each amount of water is 5-10 times, filters the extractum that relative density 1.10-1.30 obtained when filtrate was concentrated into 50 degrees centigrade.
2. the medicine for the treatment of dysmenorrhea according to claim 1, it is characterized in that: the Chinese crude drug consumption is Fructus Evodiae 18 weight portions, Ramulus Cinnamomi 18 weight portions, Radix Angelicae Sinensis 14.4 weight portions, Rhizoma Chuanxiong 14.4 weight portions, Rhizoma Corydalis 14.4 weight portions, Rhizoma Zingiberis 7.2 weight portions, Rhizoma Pinelliae Preparatum 7.2 weight portions, the Radix Paeoniae Alba 9 weight portions, Radix Glycyrrhizae 1.8 weight portions.
3. the preparation method of the medicine of the described treatment dysmenorrhea of claim 1 is characterized in that: may further comprise the steps:
A, get the raw materials ready: get by weight 10～25 parts of Fructus Evodiaes; 10～25 parts of Ramulus Cinnamomi; 8～20 parts of Radix Angelicae Sinensis; 8～20 parts of Rhizoma Chuanxiongs; 8～20 parts of Rhizoma Corydalis; 4～10 parts of Rhizoma Zingiberiss; 4～10 parts of Rhizoma Pinelliae Preparatum; 1～2.5 part in 5～15 parts of the Radix Paeoniae Albas and Radix Glycyrrhizae, and with the medical material of various components clean dry for subsequent use;
B, ethanol extraction: Ramulus Cinnamomi, Fructus Evodiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis are added the alcohol reflux three times of 4-8 times of weight 30-80%, then filter, the extractum of relative density 1.10-1.30 with filtrate recycling ethanol and when being concentrated into 50 degrees centigrade;
C, water extraction: with Rhizoma Zingiberis, Rhizoma Pinelliae Preparatum, the Radix Paeoniae Alba, Radix Glycyrrhizae, decoct with water three times, each amount of water is 5-10 times, filters the extractum of relative density 1.10-1.30 when filtrate is concentrated into 50 degrees centigrade;
D, combination drying: with two kinds of extractum mixings of gained among step b and the step c, in 50-80 degree centigrade of drying under reduced pressure, add the appropriate amount of auxiliary materials mixed pelletization after pulverizing, must treat the medicine of dysmenorrhea.
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| CN105012601A (en) * | 2015-07-27 | 2015-11-04 | 谢丽蓉 | Traditional Chinese medicine composition for treatment of cold-damp coagulation type dysmenorrhoea |
| CN107259165A (en) * | 2017-08-03 | 2017-10-20 | 宿松县玖索科技信息有限公司 | A kind of suckling animals feed and preparation method thereof |
| CN110507737A (en) * | 2019-07-09 | 2019-11-29 | 广州中医药大学(广州中医药研究院) | A kind of Chinese medicine composition and its preparation method and application |
| CN113599484A (en) * | 2021-08-06 | 2021-11-05 | 江苏金氏丹科技有限公司 | Traditional Chinese medicine composition for treating pain and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1565553A (en) * | 2003-06-18 | 2005-01-19 | 薛永新 | Dysmenorrhea treating Chinese traditional medicine |
| CN1686267A (en) * | 2005-03-16 | 2005-10-26 | 叶耀良 | Chinese medicinal preparation for channel warming and blood nourishing and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565553A (en) * | 2003-06-18 | 2005-01-19 | 薛永新 | Dysmenorrhea treating Chinese traditional medicine |
| CN1686267A (en) * | 2005-03-16 | 2005-10-26 | 叶耀良 | Chinese medicinal preparation for channel warming and blood nourishing and its preparation method |
Non-Patent Citations (1)
| Title |
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| 李香萍.原发性痛经的中西医研究进展.《辽宁中医药大学学报》.2007,第9卷(第1期),65-68. * |
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