CN103585482A - Traditional Chinese medicine composition for treating parkinson disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating parkinson disease and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine composition for treating the parkinson disease and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts of gastrodia elata, 10-15 parts of uncaria rhynchophylla, 2-5 parts of scorpio, 5-15 parts of lumbricus, 3-10 parts of periostracum cicada, 1-10 parts of bombyx batryticatus, 5-10 parts of ginseng, 10-60 parts of astragalus membranaceus, 10-30 parts of caulis spatholobi, 15-30 parts of tortoise shell, 5-10 parts of deer-horn glue, 6-15 parts of fructus psoraleae, 1-10 parts of pseudo-ginseng, 3-10 parts of ligusticum wallichii and 5-15 parts of roots of red-rooted salvia. The traditional Chinese medicine composition has the effects of benefiting vital energy, nourishing blood, benefiting essence, replenishing marrow, promoting blood circulation to remove meridian obstruction and relieving dizziness and spasm, and can be used for effectively improving or controlling symptom of the parkinson disease caused by injury of brain marrow and organs such as the liver, the spleen and the kidney and delaying the aggravation progress of the parkinson disease when being early applied.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of Parkinsonian Chinese medicine composition and preparation method thereof for the treatment of.
Background technology
Parkinson disease belong to motherland's medical science " electric shock " category, also claim " tremor " or claim " shaking ".In < < through > > the name without electric shock, but there is similar record, as < < Plain Questions the most pure virginity will be discussed greatly the performance of " falling " in > > " all wind trembling and dizziness, all belong to liver ".< < Standards of Diagnosis and Treatment miscellaneous diseases > > releases and says: " quiver, shake also; Shake, move also.Muscle arteries and veins constraint incessantly and Mo Nengren holds, the resembling also of wind ..." its pathogenesis is: the impaired degeneration occurring of the internal organs such as brains and liver,spleen,kidney.Key is deficiency of kidney essence, muscle arteries and veins cervical carcinoma with cachexia; Insufficiency of the spleen biochemical not enough, cause brains mistake and fill; Or the hot wind symptom of expectorant, causing the mind owner of lost property, muscle arteries and veins constraint is incessantly and Mo Nengren holds.Clinically take head or limbs and shake, tremble as main manifestations.
Parkinson disease are the common nervous system degeneration diseases of person in middle and old age, with black substance dopamine (DA) serotonergic neuron degeneration disappearance and Lewy body, form feature.Clinical manifestation is: static tremor, bradykinesia, myotonia and posture abnormal gait etc.And modern western medicine is not bright yet so far to the Parkinsonian cause of disease of idiopathic, more, without the Therapeutic Method of specially good effect, can only take symptomatic treatment, to improving symptom, improve the quality of living as target, but the process that the uncontrollable state of an illness increases the weight of gradually.Along with the aging of China's population, its sickness rate is ascendant trend ，Gei family and society year by year and has brought white elephant.
Summary of the invention
For overcoming the deficiencies in the prior art part, the object of the present invention is to provide a kind of Parkinsonian Chinese medicine composition and preparation method thereof for the treatment of, said composition has: the effect that benefiting QI and nourishing blood, beneficial essence are filled out marrow, promoting blood circulation to remove obstruction in the collateral, relieving spasm by subduing liver-wind; To because of the impaired parkinson disease that cause of the internal organs such as brains and liver,spleen,kidney, apply in early days, can effectively improve or control symptom, delay the process of aggravation.
For achieving the above object, the technical scheme that the present invention takes is as follows:
A Parkinsonian Chinese medicine composition, is made by each crude drug of following portions by weight: Rhizoma Gastrodiae 1-10 part, Ramulus Uncariae Cum Uncis 10-15 part, Scorpio 2-5 part, Pheretima 5-15 part, Periostracum Cicadae 3-10 part, Bombyx Batryticatus 1-10 part, Radix Ginseng 5-10 part, Radix Astragali 10-60 part, Caulis Spatholobi 10-30 part, Carapax Et Plastrum Testudinis 15-30 part, Colla cornus cervi 5-10 part, Fructus Psoraleae 6-15 part, Radix Notoginseng 1-10 part, Rhizoma Chuanxiong 3-10 part, Radix Salviae Miltiorrhizae 5-15 part.
Further, the parts by weight of described each crude drug are preferably: 10 parts, Rhizoma Gastrodiae, 12 parts of Ramulus Uncariae Cum Uncis, 3 parts of Scorpios, 10 parts of Pheretimas, 10 parts of Periostracum Cicadaes, 10 parts of Bombyx Batryticatus, 10 parts of Radix Ginsengs, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 15 parts of Carapax Et Plastrum Testudiniss, 10 parts of Colla cornus cervis, 10 parts of Fructus Psoraleaes, 10 parts of Radix Notoginseng, 10 parts of Rhizoma Chuanxiongs, 15 parts of Radix Salviae Miltiorrhizaes.
Preferably, described Carapax Et Plastrum Testudinis is for processing Carapax Et Plastrum Testudinis.
Described Chinese medicine composition is made any acceptable preparation clinically according to a conventional method, such as decoct, honeyed pill, concentrated pill or capsule.Can, according to the needs of different preparations, choose and add corresponding conventional adjuvant.
Preparation method and using method:
Acute stage decoct: in weight/volume, take Rhizoma Gastrodiae 1-10g, Ramulus Uncariae Cum Uncis 10-15g, Scorpio 2-5g, Pheretima 5-15g, Periostracum Cicadae 3-10g, Bombyx Batryticatus 1-10g, Radix Ginseng 5-10g, Radix Astragali 10-60g, Caulis Spatholobi 10-30g, Carapax Et Plastrum Testudinis 15-30g, Colla cornus cervi 5-10g, Fructus Psoraleae 6-15g, Radix Notoginseng 1-10g, Rhizoma Chuanxiong 3-10g, Radix Salviae Miltiorrhizae 5-15g, then this 15 taste Chinese medicine is put into marmite, first decocts and adds water 600ml, soak 30min, after first boiling with high heat, use again 30min at a simmer, the about 350ml of taking liquid; Second decocts and adds water 500ml, after first boiling with high heat, uses 25min at a simmer, the about 350ml of taking liquid again; After decocting liquid medicine mixing two, take at twice, service once decoction being taken warmly sooner or later.
Stable disease phase honeyed pill, concentrated pill or capsule: take by weight ratio Rhizoma Gastrodiae 1-10 part, Ramulus Uncariae Cum Uncis 10-15 part, Scorpio 2-5 part, Pheretima 5-15 part, Periostracum Cicadae 3-10 part, Bombyx Batryticatus 1-10 part, Radix Ginseng 5-10 part, Radix Astragali 10-60 part, Caulis Spatholobi 10-30 part, Carapax Et Plastrum Testudinis 15-30 part, Colla cornus cervi 5-10 part, Fructus Psoraleae 6-15 part, Radix Notoginseng 1-10 part, Rhizoma Chuanxiong 3-10 part, Radix Salviae Miltiorrhizae 5-15 part, then after this 15 taste Chinese medicine being pulverized, cross 100 orders or 120 mesh sieves, make after superfine medicated powder: 1. medicated powder and honey are made to honeyed pill by 1:1.5 part by weight, every ball 3g, each serving 6g, take every day twice, or 2. packing medicated powder into Capsules, every 0.3g, each serving 6, takes three times every day, or 3. medicated powder is made to concentrated pill by prior art processes, every 8 balls are equivalent to crude drug in whole 3g, each serving 8 balls, take every day three times.
Pharmacology of the present invention is as follows:
Rhizoma Gastrodiae: sweet in the mouth.Property is put down.Return Liver Channel.The merit with endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.This product sweet in the mouth matter profit, the property of medicine is gentle, therefore available, controls liver-wind stirring up internally, the infantile convulsion of the various causes of disease and twitches, though cold and heat and asthenia and sthenia, all can compatibility application.Dispel the in addition effect of exogenous wind, the meridian dredging of this product.With controlling the diseases such as wind apoplex involving the channels and collaterals, hands and feet caused by paralysis, numb limbs and tense tendons, joint joint stuffiness, spasm tic.Modern pharmacological research confirms: Rhizoma Gastrodiae has the effects such as peripheral blood vessel, cerebrovascular and the coronary vascular resistance of reduction.
Ramulus Uncariae Cum Uncis: sweet in the mouth.Cold nature.Return liver, pericardium channel.The merit with endogenous wind stopping relieving convulsion, heat clearing away suppressing the hyperactive liver.This product has the endogenous wind stopping relieving convulsion effect of mitigation.Common medicine for treatment liver-wind stirring up internally, infantile convulsion tic.Modern pharmacological research proves: Ramulus Uncariae Cum Uncis has the effects such as anticoagulant and antithrombotic, blood fat reducing.
Scorpio: acrid in the mouth.Property is put down.Return Liver Channel.There is the effects such as endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain.This product master enters Liver Channel, has both calmed down liver-wind, expel wind to dredge collateral again, and the effect that has endogenous wind stopping relieving convulsion concurrently and search wind relieving convulsion, has good relieving convulsion to take out effect, controls the diseases such as spasm tic of a variety of causes therefore available.
Pheretima: salty in the mouth.Cold in nature.Return liver, spleen, urinary bladder channel.There is clearing heat for calming endogenous wind, dredging collateral, relieving asthma, the merit of diuresis.This product can endogenous wind stopping relieving convulsion, is good at again heat clearing away arresting convulsion, therefore be applicable to the diseases such as unconsciousness and delirium due to extreme heat causing wind syndrome, spasm tic.
Periostracum Cicadae: sweet in the mouth.Cold in nature.Return lung, Liver Channel.Have that dispelling wind and heat pathogens, rash are antipruritic, the merit of relieving sore throat to recover voice, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion.This product can be evacuated wind-heat of liver channel, again can cool liver endogenous wind stopping relieving convulsion, therefore for the diseases such as tetany due to acute and chronic infantile convulsion, tetanus etc.
Bombyx Batryticatus: salty in the mouth.Pungent, property is flat.Return liver, lung meridian.The merit with endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses.This product can in breath liver-wind spasmolytic twitch, the exogenous wind spasmolytic of dispelling is again twitched, and hold concurrently can reduce phlegm, the effect such as arresting convulsion.Therefore be used for the diseases such as infantile convulsion tic, wind apoplex involving the channels and collaterals.
Radix Ginseng: sweet in the mouth, micro-hardship.Slightly warm in nature.GUIXIN, lung, spleen channel.There is strongly invigorating primordial QI, invigorating the spleen to benefit the lung, the merit of the Fructus Alpiniae Oxyphyllae of promoting the production of body fluid, calm the nerves.This product is strongly invigorating primordial QI both, and the gas of spleen reinforcing lung also has invigorating kidney qi effect.Can control the disease of kidney yang deficiency, deficiency of kidney-essence.Modern pharmacological research proves: this product all has potentiation to senior god's neururgic excitement of level and process of inhibition, can strengthen the motility of neural activity process, improves mental work function, can also promote the effects such as function of hemopoietic system.
The Radix Astragali: sweet in the mouth.Slightly warm in nature, returns spleen, lung meridian.There is tonifying Qi and lifting yang, benefit and defend the merit in consolidating superficial resistance, inducing diuresis to remove edema, eliminating the toxic material out by tonification.This product energy QI invigorating reaches outward with hemopoietic, reinforcing body resistance, poison holding, again can QI invigorating with promoting the circulation of blood, therefore treatment is because deficiency of vital energy hyperamization is stagnant, muscle arteries and veins loses to support and causes numbness of the skin, the unsuccessful person of limbs.Modern pharmacological research proves: the Radix Astragali can promote organism metabolism, improves anemia phenomenon.In cell culture, can make cell quantity showed increased, Growth of Cells is vigorous, life.Energy coronary artery dilator and peripheral blood vessel, reduce blood pressure, and can reduce platelet adhesion power, reduces thrombosis, also has anti-hypoxia, the anti-ageing effect of waiting for a long time.
Caulis Spatholobi: bitter in the mouth, sweet.Warm in nature.Return Liver Channel.Have that promoting the circulation of blood is enriched blood, the merit of regulating menstruation, relaxing muscles and tendons and activating QI and blood in the collateral.This product is bitter and not dry, temperature and not strong, promoting the circulation of blood, nourish blood, dissipating blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral, be that treatment passages through which vital energy circulates is smooth, the common medicine of channels discord disease.Control the diseases such as numb hand and foot that not nourishing muscle and tendon of blood deficiency, apoplexy etc. cause, quadriplegia.
Carapax Et Plastrum Testudinis: sweet in the mouth, salty.Cold in nature.Return liver, kidney, heart channel.The merit with nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, consolidating channel for hemostasis, the reinforcing the heart of nourishing blood.This product is longer than nourishing kidney yin, and holding concurrently can nourishing hepatic yin, the yang hyperactivity therefore be applicable to deficiency of liver-YIN, deficiency of the kidney yin and interior-heat and the muscles and bones of suffering from a deficiency of the kidney are strong, soreness of the waist and knees, stride is weak and deficiency of YIN-blood, heart kidney lose support etc. all diseases of caused stirring-up of pathogenic wind in the interior resulting from deficiency.
Colla cornus cervi: sweet in the mouth, salty.Warm in nature.Return liver, kidney channel.The merit with invigorating the liver and kidney, benefiting essence-blood.Be used for the treatment of muscles and bones that deficiency of kidney yang, asthenia of essence and blood the cause diseases such as soft, soreness of waist and knee joint of withering.
Fructus Psoraleae: acrid in the mouth, hardship.Warm in nature.Return kidney, spleen channel.There is the effects such as reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination.This product can invigorating the liver and kidney, bone and muscle strengthening, again can dispelling cold and dampness, warm waist knee joint, except effects such as arthralgia pain.Therefore treatment is suffered from a deficiency of the kidney, waist knee joint flaccidity is soft, all diseases of muscles and bones cold type of pain.
Radix Notoginseng: sweet in the mouth.The micro-hardship of property.Return liver, stomach warp.There is removing stasis to stop bleeding, the merit of the analgesic therapy of invigorating blood circulation.This product can be stopped blooding, again can dissipating blood stasis tissue regeneration promoting, and drug effect is distinguished, the two-way function that has hemostasis not stay the stasis of blood, blood stasis dispelling not to cause bleeding.For mass formed by blood stasis good medicine, it is again the good merchantable brand of controlling all diseases of blood stasis.Modern pharmacological research proves: Radix Notoginseng can promote the propagation of multi-functional hematopoietic stem cell, has hemoposieis; Expansion of cerebral vascular, strengthen cerebrovascular flow, therefore treatment is because of the cerebrovascular disease due to stagnation of blood stasis.
Rhizoma Chuanxiong: acrid in the mouth.Warm in nature.Return liver, gallbladder, pericardium channel.The effect with blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is logical, can invigorate blood circulation, again can circulation of qi promoting, be " gas medicine in blood ", can " lower regulating menstruation water, middle relieving stagnation, the up head ", can also " bypass channels ", expelling wind and activating blood circulation pain relieving.Modern pharmacological research proves: Rhizoma Chuanxiong can significantly increase brain and LBF amount, improves microcirculation, can reduce surface activity of blood platelet, suppresses platelet aggregation, antithrombotic.Therefore the diseases such as available ischemic cerebrovascular, peripheral neuritis.
Radix Salviae Miltiorrhizae: bitter in the mouth.Cold nature.GUIXIN, Liver Channel.There is the merit that promoting blood flow to regulate menstruation, removing heat from blood eliminating carbuncle, relieving restlessness are calmed the nerves.This product is blood circulation promoting and blood stasis dispelling key medicine, is widely used in various blood stasis symptoms.Therefore can be used for the treatment of the diseases such as ischemic cerebrovascular, atherosclerosis.Modern pharmacological research proves: this product can be expanded peripheral blood vessel, improves hemorheological property, reduces blood viscosity, and anticoagulant activates fibrinolytic, antagonism thrombosis; Can protect erythrocyte membrane, can regulate blood fat, suppress the effects such as formation of atheromatous plaque.
Chinese medicine composition of the present invention has benefiting QI and nourishing blood, beneficial essence is filled out the effects such as marrow, blood circulation promoting and blood stasis dispelling, endogenous wind stopping relieving convulsion; Be mainly used in treatment because of insufficiency of the spleen biochemical deficiency cause brains lose fill, deficiency of kidney essence, muscle arteries and veins cervical carcinoma with cachexia; Or the hot wind symptom of expectorant, causing the mind owner of lost property, muscle arteries and veins constraint is incessantly and head or the limbs of Mo Nengren due to the holding disease such as shake, tremble is evident in efficacy; Can effectively improve or control clinical symptoms, delaying or part is controlled the progress of the state of an illness, effectively having made up and with Western medicine, can not effectively control the drawback that the state of an illness increases the weight of gradually merely.
The specific embodiment
Below in conjunction with specific embodiment, technical solution of the present invention is done to introduce in detail further, but protection scope of the present invention is not limited to this:
Embodiment 1
Rhizoma Gastrodiae 7g, Ramulus Uncariae Cum Uncis 15g, Scorpio 2g, Pheretima 5g, Periostracum Cicadae 7g, Bombyx Batryticatus 3g, Radix Ginseng 7g, Radix Astragali 60g, Caulis Spatholobi 10g, Carapax Et Plastrum Testudinis (processing) 20g, Colla cornus cervi 7g, Fructus Psoraleae 15g, Radix Notoginseng 3g, Rhizoma Chuanxiong 7g, Radix Salviae Miltiorrhizae 10g.
Preparation method and using method
Acute stage water decoction: above-mentioned 15 taste Chinese medicines are put into marmite, and first decocts and adds water 600ml, soaks 30min, after first boiling with high heat, uses 30min at a simmer, the about 350ml of taking liquid again; Second decocts and adds water 500ml, after first boiling with high heat, uses 25min at a simmer, the about 350ml of taking liquid again; After decocting liquid medicine mixing two, take at twice, service once decoction being taken warmly sooner or later.
The stable disease phase is used honeyed pill, concentrated pill or capsule: after above-mentioned 15 taste Chinese medicines are pulverized, cross 100 orders or 120 mesh sieves, make after superfine medicated powder: 1. medicated powder is made to honeyed pill with sweet by 1:1.5 part by weight, every ball 3g, each serving 6g, takes twice every day; Or 2. packing medicated powder into Capsules, every 0.3g, each serving 6, takes three times every day; Or 3. medicated powder is made to concentrated pill by prior art processes, every 8 balls are equivalent to crude drug in whole 3g, each serving 8 balls, take every day three times.
Embodiment 2
Rhizoma Gastrodiae 10g, Ramulus Uncariae Cum Uncis 12g, Scorpio 3g, Pheretima 10g, Periostracum Cicadae 10g, Bombyx Batryticatus 10g, Radix Ginseng 10g, Radix Astragali 30g, Caulis Spatholobi 15g, Carapax Et Plastrum Testudinis (processing) 15g, Colla cornus cervi 10g, Fructus Psoraleae 10g, Radix Notoginseng 10g, Rhizoma Chuanxiong 10g, Radix Salviae Miltiorrhizae 15g.
Preparation method and using method are with embodiment 1.
Embodiment 3
Rhizoma Gastrodiae 3g, Ramulus Uncariae Cum Uncis 10g, Scorpio 5g, Pheretima 15g, Periostracum Cicadae 3g, Bombyx Batryticatus 7g, Radix Ginseng 5g, Radix Astragali 10g, Caulis Spatholobi 30g, Carapax Et Plastrum Testudinis (processing) 30g, Colla cornus cervi 5g, Fructus Psoraleae 6g, Radix Notoginseng 7g, Rhizoma Chuanxiong 3g, Radix Salviae Miltiorrhizae 5g.
Preparation method and using method are with embodiment 1.
clinical trial
1.1 physical data
From year June in January, 2000 to 2013, Parkinsonian's 60 examples are accepted in screening for medical treatment.All cases is all through multiple inspections such as physical examination and head CT or nuclear-magnetisms, and ties clinical symptoms and make a definite diagnosis, and bad without organ functions such as serious liver, kidney, the hearts.Be divided at random treatment group 30 examples, wherein, male 21 examples, female's 9 examples, age: 40-49 year, 3 examples; 50-59 year, 10 examples; 60-69 year, 12 examples; 70-80 year, 5 examples; 66.9 years old mean age; Matched group 30 examples, wherein, male 20 examples, female's 10 examples, age: 40-49 year, 2 examples; 50-59 year, 11 examples; 60-69 year, 11 examples; 70-80 year, 6 examples; 70 years old mean age.Two groups at aspects such as sex, age, the state of an illness more all without significant difference (p ﹥ 0.05), there is comparability, refer to table 1.
Table 1 liang group case ordinary circumstance comparison
Note: two groups of comparisons: p ﹥ 0.05
1.2 diagnostic criteria
1. there are the inducements such as prolonged illness or old deficiency of the kidney oligospermia, the unable promoting the circulation of blood of weakness of QI; 2. head tremor is moving; 3. hands, the vibration of sufficient limbs are incessantly; 4. severe patient has spasm to reverse sample action, spasm of the limbs; 5. instability of gait, biped is wiped ground walking and is waited a moment; 6. pale tongue or dark red, thready and weak pulse or string are puckery; 7. head CT or nuclear-magnetism show: have the focuses such as intracranial ischemic or hemorrhagic.
1.3 Therapeutic Method
Matched group: adopt routine of western medicine treatment, control symptom Benserazide sheet, every 0.25g, each serving 1/2, every day 3 times, a Zhou Houke changes each 1/2 into, every day 2 times, 1 and a half hours after the meal clothes, other adopts symptomatic treatment.
Treatment group: with on routine of western medicine treatment basis, add the embodiment of the present invention 2 prescriptions and preparation method thereof, using method at matched group.
Treat respectively after 8 weeks for two groups, two groups treat forward and backward clinical symptoms, improvement situation compares.
1.4 therapeutic evaluatioies:
1.4.1 effective: head, hands, foot tremble basic disappearance, and spasm of the limbs disappears substantially, and gait is steady, and walking is very fast, energy leaping over obstacles, it is light red that body of the tongue turns, and it is normal that pulse recovers.
1.4.2 effective: head, hands, foot vibration alleviate or substantially disappear, and spasm of the limbs alleviates or disappears, and gait is more steady, walk still fast, still can leaping over obstacles, tongue, arteries and veins recovery are normally.
1.4.3 invalid: head, hands, foot vibration be without improving, spasm of the limbs, instability of gait, ground, is slowly wiped in biped walking, dare not leaping over obstacles, tongue, arteries and veins are without improvement.
1.5 statistical method
Data represent by rate, adopt x
2check, take p < 0.05 as difference, has statistical significance.
1.6 result
1.6.1 before and after treatment, two groups of symptoms are improved situation comparison
Treatment group is at matched group with adding Chinese medicine composition of the present invention on routine of western medicine treatment basis, and clinical symptoms improvement rate (84%) is obviously better than matched group merely by routine of western medicine treatment clinical symptoms improvement rate (47%), refers to table 2.
Before and after table 2 liang group treatment, clinical symptoms is improved number of cases and improvement rate
Note: improve=effective+effectively
1.6.2 untoward reaction
Matched group has 2 examples to occur symptom fluctuation, has that feeling sick appears in 6 examples, a vomiting, abdominal discomfort.Treatment group is not found any untoward reaction.
model case
Case 1
Take charge of so-and-so, man, 60 years old, peasant ，Xi Xishao township waited Gu Ningfu people from village, on May 18th, 2002, with " parkinson disease ", comes inventor to locate to go to a doctor.Patient before 2 years without obviously occurring that head shakes to inducement, time have brothers' ，Zeng Dao Puyang the People's Hospital's diagnosis and treatment of trembling, by " parkinson disease ", give the medicine treatments such as Benserazide sheet, heavy when light during symptom, then go to Beijing 301 Hospital to check treatment (medication is not quite clear), remission.In nearly March, head swings, and both hands tremble and increase the weight of gradually, therefore come inventor to locate to go to a doctor.Disease is seen: head shakes, and both hands tremble, and can not hold thing, have a dizzy spell, and tinnitus, forgetful, dysuria, corpulent tongue is large, and body of the tongue is light red, white and thin fur, deep and weak pulse.
Dialectical analysis: kidney governing bones, the raw marrow of bone, marrow fills in brain.Deficiency of kidney-essence, liver-yin is also not enough, the deficiency of YIN of Liver and kidney, wind sun rises and moves, therefore see that head tremor limb quivers.Kidney-jing deficiency, deficiency of marrow-reservoir, brain is become homeless foster, has a dizzy spell, tinnitus, hypomnesis; Corpulent tongue is large, and body of the tongue is light red, and deep and weak pulse is resembling of caused by liver and kidney deficiency.
Tcm diagnosis: electric shock (deficiency of marrow-reservoir).
The rule for the treatment of: benefiting QI and nourishing blood, beneficial essence is filled out marrow, blood circulation promoting and blood stasis dispelling, endogenous wind stopping relieving convulsion.
Side's medicine: the embodiment of the present invention 2 prescriptions, preparation method and using method.
Western medicine: with Benserazide, every 0.25g, each serving 1/2, every day 3 times, a Zhou Houke changes each 1/2 into, and every day 2 times, 1 and a half hours after the meal clothes, to control symptom; Control blood pressure with enalapril etc., other adopts symptomatic treatment.
After treating 6 weeks, patient's head shakes basic disappearance, and both hands tremble and obviously alleviate, and can hold flexibly thing, the disappearance of having a dizzy spell, and tinnitus, forgetful, dysuria obviously alleviate, and tongue, arteries and veins recover as usual.Advise and continue to take 3 weeks again, all symptoms disappear substantially, advise to change and take capsule, each 6, every day 3 times, to consolidate curative effect, prevent course advancement.Follow up a case by regular visits to through annual 2 times, this conditions of patients is stable so far, without obvious progress.
Case 2
Zhang, female, 66 years old, workman, was Nanyue County retired employees of sewing society.On July 19th, 2006, with " parkinson disease ", come inventor to locate to go to a doctor.Patient, before 5 years, occurs that the People's Hospital, head tremor limb Chan，Zeng Dao Nanyue County, Puyang the People's Hospital etc. locate diagnosis and treatment unknown cause, and effect is not good enough.In nearly February, head shakes, and both hands tremble and increase the weight of, therefore come inventor to locate to seek medical advice.Disease is seen: head shakes, can not be from controlling, and both hands tremble, and dizziness and blurred vision is weak, deficiency of QI with disinclination to talk, anorexia, corpulent tongue is large, has indentation, and body of the tongue is talked, white and thin fur, thready and weak pulse.
Dialectical analysis: prolonged illness QI and blood deficiency, muscle arteries and veins loses in moistening foster, therefore see that head tremor limb quivers.The deficiency of vital energy is weak, deficiency of QI with disinclination to talk, and the paddy that receives is unclear.Blood deficiency can not go up Rong Qing key, sees dizziness and blurred vision.Corpulent tongue is large, has indentation, and body of the tongue is talked, white and thin fur, and thready and weak pulse, is resembling of deficiency of qi and blood.
Tcm diagnosis: electric shock (deficiency of qi and blood).
The rule for the treatment of: benefiting QI and nourishing blood, beneficial essence is filled out marrow, blood circulation promoting and blood stasis dispelling, endogenous wind stopping relieving convulsion.
Side's medicine: the embodiment of the present invention 2 prescriptions, preparation method and using method.
Western medicine: control symptom Benserazide, every 0.25g, each serving 1/2, takes 3 times every day, and a Zhou Houke changes each 1/2 into, every day 2 times, 1 and a half hours after the meal clothes; Control blood pressure with indopamide etc., other adopts symptomatic treatment measure.
After treating 5 weeks, patient's head shakes basic disappearance, and both hands tremble and significantly alleviate, and can hold thing, and dizziness and blurred vision disappears, and weak, deficiency of QI with disinclination to talk is clearly better, diet amelioration, and tongue, arteries and veins recover normal.Advise and continue to take 3 weeks again, all symptoms disappear substantially, advise to change and take capsule, and every 0.3g, each serving 6, takes 3 times every day, to consolidate curative effect, prevents course advancement.Through following up a case by regular visits to every year, this conditions of patients is stable so far, without obviously making progress.
Claims (7)
1. the Parkinsonian Chinese medicine composition for the treatment of, is characterized in that being made by each crude drug of following portions by weight: Rhizoma Gastrodiae 1-10 part, Ramulus Uncariae Cum Uncis 10-15 part, Scorpio 2-5 part, Pheretima 5-15 part, Periostracum Cicadae 3-10 part, Bombyx Batryticatus 1-10 part, Radix Ginseng 5-10 part, Radix Astragali 10-60 part, Caulis Spatholobi 10-30 part, Carapax Et Plastrum Testudinis 15-30 part, Colla cornus cervi 5-10 part, Fructus Psoraleae 6-15 part, Radix Notoginseng 1-10 part, Rhizoma Chuanxiong 3-10 part, Radix Salviae Miltiorrhizae 5-15 part.
2. the Parkinsonian Chinese medicine composition for the treatment of as claimed in claim 1, is characterized in that being made by each crude drug of following portions by weight: 10 parts, Rhizoma Gastrodiae, 12 parts of Ramulus Uncariae Cum Uncis, 3 parts of Scorpios, 10 parts of Pheretimas, 10 parts of Periostracum Cicadaes, 10 parts of Bombyx Batryticatus, 10 parts of Radix Ginsengs, 30 parts of the Radixs Astragali, 15 parts of Caulis Spatholobis, 15 parts of Carapax Et Plastrum Testudiniss, 10 parts of Colla cornus cervis, 10 parts of Fructus Psoraleaes, 10 parts of Radix Notoginseng, 10 parts of Rhizoma Chuanxiongs, 15 parts of Radix Salviae Miltiorrhizaes.
3. the Parkinsonian Chinese medicine composition for the treatment of as claimed in claim 1 or 2, is characterized in that: described Carapax Et Plastrum Testudinis is for processing Carapax Et Plastrum Testudinis.
4. the Parkinsonian Chinese medicine composition for the treatment of as claimed in claim 1 or 2, is characterized in that: make according to a conventional method any acceptable preparation clinically.
5. the Parkinsonian Chinese medicine composition for the treatment of as claimed in claim 4, is characterized in that: described preparation is decoct, honeyed pill, concentrated pill or capsule.
6. a preparation method for the treatment of Parkinsonian Chinese medicine composition, it is characterized in that: in weight/volume, take Rhizoma Gastrodiae 1-10g, Ramulus Uncariae Cum Uncis 10-15g, Scorpio 2-5g, Pheretima 5-15g, Periostracum Cicadae 3-10g, Bombyx Batryticatus 1-10g, Radix Ginseng 5-10g, Radix Astragali 10-60g, Caulis Spatholobi 10-30g, Carapax Et Plastrum Testudinis 15-30g, Colla cornus cervi 5-10g, Fructus Psoraleae 6-15g, Radix Notoginseng 1-10g, Rhizoma Chuanxiong 3-10g, Radix Salviae Miltiorrhizae 5-15g, then this 15 taste Chinese medicine is put into marmite, first decocts and adds water 600ml, soak 30min, after first boiling with high heat, use again 30min at a simmer, the about 350ml of taking liquid, second decocts and adds water 500ml, after first boiling with high heat, uses 25min at a simmer, the about 350ml of taking liquid again, after decocting liquid medicine mixing two, make decoct.
7. a preparation method for the treatment of Parkinsonian Chinese medicine composition, it is characterized in that: take by weight ratio Rhizoma Gastrodiae 1-10 part, Ramulus Uncariae Cum Uncis 10-15 part, Scorpio 2-5 part, Pheretima 5-15 part, Periostracum Cicadae 3-10 part, Bombyx Batryticatus 1-10 part, Radix Ginseng 5-10 part, Radix Astragali 10-60 part, Caulis Spatholobi 10-30 part, Carapax Et Plastrum Testudinis 15-30 part, Colla cornus cervi 5-10 part, Fructus Psoraleae 6-15 part, Radix Notoginseng 1-10 part, Rhizoma Chuanxiong 3-10 part, Radix Salviae Miltiorrhizae 5-15 part, then after this 15 taste Chinese medicine being pulverized, cross 100 orders or 120 mesh sieves, make after superfine medicated powder: 1. medicated powder and honey are made to honeyed pill by 1:1.5 part by weight, every ball 3g, or 2. pack medicated powder into Capsules and make capsule, every 0.3g, or 3. medicated powder is made to concentrated pill by prior art processes, every 8 balls are equivalent to crude drug in whole 3g.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800610A (en) * | 2015-05-18 | 2015-07-29 | 宋思佳 | Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof |
| CN104800604A (en) * | 2015-04-20 | 2015-07-29 | 韩萍 | Traditional Chinese medicine formula for treating Parkinsonism |
| CN105535319A (en) * | 2016-01-05 | 2016-05-04 | 陈杏芬 | Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof |
| WO2017114322A1 (en) * | 2015-12-30 | 2017-07-06 | 张鹏 | Traditional chinese medicine for treating paralysis agitans and preparation method therefor |
| CN107334954A (en) * | 2017-07-18 | 2017-11-10 | 河南中医药大学 | A kind of Chinese medicine composition for treating Parkinson's and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113808A (en) * | 1994-06-14 | 1995-12-27 | 鲁守龙 | Medicine for curing nervous system injury and angionosis |
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2013
- 2013-11-20 CN CN201310584420.4A patent/CN103585482B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113808A (en) * | 1994-06-14 | 1995-12-27 | 鲁守龙 | Medicine for curing nervous system injury and angionosis |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800604A (en) * | 2015-04-20 | 2015-07-29 | 韩萍 | Traditional Chinese medicine formula for treating Parkinsonism |
| CN104800610A (en) * | 2015-05-18 | 2015-07-29 | 宋思佳 | Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof |
| WO2017114322A1 (en) * | 2015-12-30 | 2017-07-06 | 张鹏 | Traditional chinese medicine for treating paralysis agitans and preparation method therefor |
| CN105535319A (en) * | 2016-01-05 | 2016-05-04 | 陈杏芬 | Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof |
| CN107334954A (en) * | 2017-07-18 | 2017-11-10 | 河南中医药大学 | A kind of Chinese medicine composition for treating Parkinson's and preparation method thereof |
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| CN103585482B (en) | 2015-07-22 |
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