CN104208438A - Traditional Chinese medicine for treating cardiovascular stenosis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating cardiovascular stenosis. The traditional Chinese medicine comprises 20-30g of hawthorn fruit, 20-30g of Polygonum multiflorum, 20-30g of Spica Prunellae, 15-25g of Vaccaria segetalis, 15-25g of Boswellia carteri, 15-25g of myrrh, 15-25g of Gynostemma pentaphylla, 15-25g of white peony root, 15-25g of Chinese angelica, 15-25g of mushroom, 10-15g of dendrobium, 10-15g of Radix Asparagi, 10-15g of Radix Polygalae, 10-15g of Fructus Toosendan, 15-25g of Radix Codonopsis, 10-15g of musk and 8-12g of licorice root. The traditional Chinese medicine has the advantages of simple ratio and use convenience, and has the efficacies of qi moving, blood circulation invigorating, smooth muscle cell proliferation inhibiting, platelet aggregation preventing and thrombus formation inhibiting.

Description

A kind ofly treat the Chinese medicine that cardiovascular is narrow

 

Technical field

The present invention relates to technical field of Chinese medicines, particularly a kind ofly treat the Chinese medicine that cardiovascular is narrow.

 

Background technology

The patient that cardiovascular is narrow there will be uncomfortable in chest, breathes hard, and the symptoms such as angina pectoris, electrocardio can change, and seriously also may occur myocardial ischemia.Theory of Chinese medical science, on tongue arteries and veins, to observe and take the deficiency of vital energy as main, expectorant stasis of blood sign is lighter, and it is abundanter that coronary angiography shows that patient's side is propped up recycle ratio, and there is stenotic condition in lesion vessels, belongs to " blockage of the cardiac vessels " of the traditional Chinese medical science.This sick morbidity is artificially the highest with old age, and it is empty that the disease in old age mostly is, so pathogenesis is deficiency in origin and excess in superficiality.Void comprises the void of the five internal organs, but take, has a guilty conscience as principal contradiction, have a guilty conscience and must involve yang blood and qi, and be gently deficiency of vital energy blood deficiency, heavy yang blood and qi is all empty, very faints de-.Actually be " expectorant " and " stasis of blood ".As for empty and real who first problem after whom, general theory is thought first void, and rear just have a reality.Have a guilty conscience and cause that QI and blood mistake is smooth, gas and blood, interdependence between yin and yang, qi as the commander of blood, blood being the mother of qi, and blood is capable with gas, and up to going blood, gas is that initiatively blood is passive.The deficiency of vital energy is raw expectorant, stops disorder of QI movement in phlegm-damp, the stagnation of QI hyperamization stasis of blood, and deficiency of vital energy blood is weak, the hyperamization stasis of blood again, blood stasis can react on gas, causes the stagnation of QI or the deficiency of vital energy further increases the weight of.

Pathology are thought: the hyperplasia of thrombosis and internal film tissue is to cause narrow main cause, and therefore, just treatment of vascular is narrow more effectively for the formation of inhibition thrombosis and/or hamartoplasia.Given this, narrow with chemoprophylaxiss such as anticoagulant, platelet suppressant drug, prostaglandin antagonists, lipid regulating agent, glucocorticoid, angiotensin converting enzyme inhibitor and somatostatin analogue, but all end obtains satisfied result, because its old complaint is qi depression to blood stasis.Therefore, the traditional Chinese medical science think take QI invigorating reduce phlegm invigorate blood circulation as main Chinese medicine be the narrow principle for the treatment of cardiovascular.Blockage of the cardiac vessels, the blood stasis of blood is stagnant is its Etiological.Conventional prescription is as Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae, and Radix Notoginseng is the product of activating blood circulation and dissipating phlegm, and warming middle-JIAO is regulated the flow of vital energy, Radix Bupleuri depressed liver-energy dispersing and QI regulating, and all medicines are 5 adapteds mutually, to reach blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral, jointly play the effect that prevents restenosis.According to the background of above-mentioned prior art, it is simple that the present invention aims to provide a kind of proportioning, easy to use, promoting flow of QI and blood, the hypertrophy of inhibition smooth muscle cell; Prevent platelet aggregation, formation a kind of who suppresses thrombosis treats the Chinese medicine that cardiovascular is narrow.

 

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of proportioning simple, easy to use, promoting flow of QI and blood, the hypertrophy of inhibition smooth muscle cell; Prevent platelet aggregation, formation a kind of who suppresses thrombosis treats the Chinese medicine that cardiovascular is narrow.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine that cardiovascular is narrow for the treatment of, wherein, comprise configure according to unit of weight as follows: Fructus Crataegi 20-30g, Radix Polygoni Multiflori 20-30g, Spica Prunellae 20-30g, Semen Vaccariae 15-25g, Olibanum 15-25g, Myrrha 15-25g, Herb Gynostemmae Pentaphylli 15-25g, Radix Paeoniae Alba 15-25g, Radix Angelicae Sinensis 15-25g, Lentinus Edodes 15-25g, Herba Dendrobii 10-15g, Radix Asparagi 10-15g, Radix Polygalae 10-15g, Fructus Toosendan 10-15g, Radix Codonopsis 15-25g, Moschus 10-15g, Radix Glycyrrhizae 8-12g.

Or, comprise configure according to unit of weight as follows: Fructus Crataegi 20-25g, Radix Polygoni Multiflori 20-25g, Spica Prunellae 20-25g, Semen Vaccariae 15-20g, Olibanum 15-20g, Myrrha 15-20g, Herb Gynostemmae Pentaphylli 15-20g, Radix Paeoniae Alba 15-20g, Radix Angelicae Sinensis 15-20g, Lentinus Edodes 15-20g, Herba Dendrobii 10-12g, Radix Asparagi 10-12g, Radix Polygalae 10-12g, Fructus Toosendan 10-12g, Radix Codonopsis 15-20g, Moschus 10-12g, Radix Glycyrrhizae 8-10g.

Or, comprise configure according to unit of weight as follows: Fructus Crataegi 25-30g, Radix Polygoni Multiflori 25-30g, Spica Prunellae 25-30g, Semen Vaccariae 20-25g, Olibanum 20-25g, Myrrha 20-25g, Herb Gynostemmae Pentaphylli 20-25g, Radix Paeoniae Alba 20-25g, Radix Angelicae Sinensis 20-25g, Lentinus Edodes 20-25g, Herba Dendrobii 12-15g, Radix Asparagi 12-15g, Radix Polygalae 12-15g, Fructus Toosendan 12-15g, Radix Codonopsis 20-25g, Moschus 12-15g, Radix Glycyrrhizae 10-12g.

Or, comprise configure according to unit of weight as follows: Fructus Crataegi 22-28g, Radix Polygoni Multiflori 22-28g, Spica Prunellae 22-28g, Semen Vaccariae 18-22g, Olibanum 18-22g, Myrrha 18-22g, Herb Gynostemmae Pentaphylli 18-22g, Radix Paeoniae Alba 18-22g, Radix Angelicae Sinensis 18-22g, Lentinus Edodes 18-22g, Herba Dendrobii 11-14g, Radix Asparagi 11-14g, Radix Polygalae 11-14g, Fructus Toosendan 11-14g, Radix Codonopsis 18-22g, Moschus 11-14g, Radix Glycyrrhizae 9-11g.

The preparation method of the Chinese medicine that treatment cardiovascular is narrow, dosage form is honey refining pill, its preparation method comprises the following steps:

Described component is soaked 30 minutes to 1 hour, and heated and boiled 30 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, cooling after drying, and mixes and is twisted into slice, pill wax seal packing with Mel;

Dosage form is capsule, its preparation method comprises the following steps: each component is added to 10 times of amount ethanol of weight, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The adsorption resin column that described filtrate flow is 10L through volume, uses deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule;

Dosage form is tablet, and its preparation method comprises the following steps: the chopping of each component is joined in multi-function extractor, and adding ratio of weight and number is the water soaking 30～40 minutes of 3000 parts, decocts after 1.5 hours, takes out that decoction liquor is standby for the first time; It is that the decocting of 3000 parts boiled after 1 hour that medicinal residues add ratio of weight and number, take out decoction liquor for the second time, aforementioned twice decoction liquor merged and filtered, it is the solution of 1000 parts that filtrate decompression is concentrated into ratio of weight and number, staticly settle 24～36 hours, draw supernatant, add starch after being heated to 40～50 ℃, heating is concentrated into pasty state, put into baking oven, be controlled at 80 ℃, cooling after drying, film-making, dry, molding, subpackage;

Dosage form is drop pill, and its preparation method comprises the following steps: the water that each component is mixed and added its weight sum 5-7 doubly to measure, put into multi-function extractor, and keep air pressure at 0.04-0.06mPa, decoct 2 hours; Repeat above-mentioned steps and again extract 1.5 hours, extracting liquid filtering 100 mesh sieves; With the refining filtrate of adsorbent resin, with ethanol elution; Eluent is evaporated to density 1.33-1.35, input air pressure 0.04-0.06mPa wherein, and vacuum is-0.076 ~-0.088mPa, stand for standby use; Repeating abovementioned steps extracts 1 hour again; Extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate, to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitated liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure is 0.04-0.06mPa, vacuum is 0.076-0.088mPa; Use sephadex chromatography is refining, with ethanol elution; Eluent is concentrated into density and is 1.33-1.35, standing; Get above-mentioned two kinds of standing liquid and add PEG-4000, mix; Mixture heating and melting; With pill dripping machine, mixture is made to compound dripping pill.

 

Advantage of the present invention is: removing blood stasis, promoting flow of QI and blood, the hypertrophy of inhibition smooth muscle cell; Prevent platelet aggregation, suppress the formation of thrombosis, the present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, easy to use, and healing time is short, after curing, is difficult for recurrence.Can create good social value and economic interests.

Its cardinal principle is: Radix Polygoni Multiflori can increase enterokinesia, suppresses metabolism of lipid and cholesterol and absorbs; Fructus Crataegi promotes lipid transfer and removing, and the HDL-C that can raise reduces LDL-C.The effect of Spica Prunellae to cardiovascular system: Spica Prunellae decoct (concentration is 1:10 ten thousand～1:100 ten thousand) can make Cor Leporis in place and isolated frog heart shrinkage amplitude increase, but concentration increases (1:20～1:50) makes shrinkage amplitude diminish. the water-leach liquor of Spica Prunellae, ethanol water-leach liquor and 30% ethanol extraction, give anesthetized animal lumbar injection, intravenous injection or the oral effect that all reduces blood pressure, intravenous injection hypotensive effect is obvious, oral administration hypotensive effect is faint. and decoct (100mg/kg) is injected in anesthetized dog, can produce significantly lasting hypotensive effect, but there is tachylaxis, after vagotomy, its hypotensive effect obviously weakens. to renal hypertension dog, take medicine continuously after 2 weeks, blood pressure has moderate reduction, after drug withdrawal, return to again originally level. Spica Prunellae stem, leaf, fringe and herb all have hypotensive effect, a little less than the effect of fringe. this three herbal medicine is monarch drug, be used in conjunction with promoting flow of QI and blood, removing blood stasis as Olibanum, Myrrha, the medicines such as Fructus Toosendan are strengthened drug effect as ministerial drug, in we, Lentinus Edodes contains a kind of nucleic acid material, can suppress the generation of cholesterol, and can prevent that arteriosclerosis and blood vessel from becoming fragile.Other adjuvant drug and make medicine coordinate monarch drug, ministerial drug to carry out compatibility, makes the present invention obtain good curative effect.Through the narrow patient of 60 routine cardiovascular, observe effective percentage 86.5%, rate of good 90.8%.

 

The specific embodiment

Prescription of the present invention is: Fructus Crataegi 20-30g, Radix Polygoni Multiflori 20-30g, Spica Prunellae 20-30g, Semen Vaccariae 15-25g, Olibanum 15-25g, Myrrha 15-25g, Herb Gynostemmae Pentaphylli 15-25g, Radix Paeoniae Alba 15-25g, Radix Angelicae Sinensis 15-25g, Lentinus Edodes 15-25g, Herba Dendrobii 10-15g, Radix Asparagi 10-15g, Radix Polygalae 10-15g, Fructus Toosendan 10-15g, Radix Codonopsis 15-25g, Moschus 10-15g, Radix Glycyrrhizae 8-12g.

Or, comprise configure according to unit of weight as follows: Fructus Crataegi 20-25g, Radix Polygoni Multiflori 20-25g, Spica Prunellae 20-25g, Semen Vaccariae 15-20g, Olibanum 15-20g, Myrrha 15-20g, Herb Gynostemmae Pentaphylli 15-20g, Radix Paeoniae Alba 15-20g, Radix Angelicae Sinensis 15-20g, Lentinus Edodes 15-20g, Herba Dendrobii 10-12g, Radix Asparagi 10-12g, Radix Polygalae 10-12g, Fructus Toosendan 10-12g, Radix Codonopsis 15-20g, Moschus 10-12g, Radix Glycyrrhizae 8-10g.

Or, comprise configure according to unit of weight as follows: Fructus Crataegi 25-30g, Radix Polygoni Multiflori 25-30g, Spica Prunellae 25-30g, Semen Vaccariae 20-25g, Olibanum 20-25g, Myrrha 20-25g, Herb Gynostemmae Pentaphylli 20-25g, Radix Paeoniae Alba 20-25g, Radix Angelicae Sinensis 20-25g, Lentinus Edodes 20-25g, Herba Dendrobii 12-15g, Radix Asparagi 12-15g, Radix Polygalae 12-15g, Fructus Toosendan 12-15g, Radix Codonopsis 20-25g, Moschus 12-15g, Radix Glycyrrhizae 10-12g.

Or, comprise configure according to unit of weight as follows: Fructus Crataegi 22-28g, Radix Polygoni Multiflori 22-28g, Spica Prunellae 22-28g, Semen Vaccariae 18-22g, Olibanum 18-22g, Myrrha 18-22g, Herb Gynostemmae Pentaphylli 18-22g, Radix Paeoniae Alba 18-22g, Radix Angelicae Sinensis 18-22g, Lentinus Edodes 18-22g, Herba Dendrobii 11-14g, Radix Asparagi 11-14g, Radix Polygalae 11-14g, Fructus Toosendan 11-14g, Radix Codonopsis 18-22g, Moschus 11-14g, Radix Glycyrrhizae 9-11g.

The preparation method of the Chinese medicine that treatment cardiovascular is narrow, dosage form is honey refining pill, its preparation method comprises the following steps:

Described component is soaked 30 minutes to 1 hour, and heated and boiled 30 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, cooling after drying, and mixes and is twisted into slice, pill wax seal packing with Mel;

Dosage form is capsule, its preparation method comprises the following steps: each component is added to 10 times of amount ethanol of weight, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The adsorption resin column that described filtrate flow is 10L through volume, uses deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule;

Dosage form is tablet, and its preparation method comprises the following steps: the chopping of each component is joined in multi-function extractor, and adding ratio of weight and number is the water soaking 30～40 minutes of 3000 parts, decocts after 1.5 hours, takes out that decoction liquor is standby for the first time; It is that the decocting of 3000 parts boiled after 1 hour that medicinal residues add ratio of weight and number, take out decoction liquor for the second time, aforementioned twice decoction liquor merged and filtered, it is the solution of 1000 parts that filtrate decompression is concentrated into ratio of weight and number, staticly settle 24～36 hours, draw supernatant, add starch after being heated to 40～50 ℃, heating is concentrated into pasty state, put into baking oven, be controlled at 80 ℃, cooling after drying, film-making, dry, molding, subpackage;

Dosage form is drop pill, and its preparation method comprises the following steps: the water that each component is mixed and added its weight sum 5-7 doubly to measure, put into multi-function extractor, and keep air pressure at 0.04-0.06mPa, decoct 2 hours; Repeat above-mentioned steps and again extract 1.5 hours, extracting liquid filtering 100 mesh sieves; With the refining filtrate of adsorbent resin, with ethanol elution; Eluent is evaporated to density 1.33-1.35, input air pressure 0.04-0.06mPa wherein, and vacuum is-0.076 ~-0.088mPa, stand for standby use; Repeating abovementioned steps extracts 1 hour again; Extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate, to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitated liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure is 0.04-0.06mPa, vacuum is 0.076-0.088mPa; Use sephadex chromatography is refining, with ethanol elution; Eluent is concentrated into density and is 1.33-1.35, standing; Get above-mentioned two kinds of standing liquid and add PEG-4000, mix; Mixture heating and melting; With pill dripping machine, mixture is made to compound dripping pill.

Prescription of the present invention can be used to be decocted in water for oral dose and take, and every day, potion, took at twice on the 1st, within 7 days, was a course for the treatment of.

 

Chinese medicine preparation pharmacodynamic study of the present invention:

1,, after insufficiency of heart-QI model mice application Chinese medicine preparation of the present invention, to hanging the anxiety causing, there is obvious inhibitory action; Extended the length of one's sleep; Muscular tension increases, stand up time extends; Adopting water maze method to record memory increases; Under normal pressure, hypoxia endurance time extends; Insufficiency of heart-QI mice heart rate is recovered;

2,, after normal mouse application Chinese medicine preparation of the present invention, the anxiety that forced swimming method and suspension method are caused has obvious sedation; Obviously extended the length of one's sleep of mice; Immunologic function is significantly improved, mononuclear phagocyte phagocytic index and activate the phagocytic capacity are obviously increased, mice serum amboceptor significantly raises;

3, the hypertension of neuroendocrine type Hypertensive Rats is had to obvious reducing effect; Heart rate obviously recovers; The length of one's sleep, significant prolongation, had obvious synergism with pentobarbital sodium; The test of water maze method is visible, and the memory of rat model is increased, and the time stopping in labyrinth obviously shortens; Visible with head-breaking test, Chinese medicine of the present invention obviously extends the time of opening one's mouth after rat broken end.

Acute toxicity testing:

The oral maximum dosage-feeding of mice of Chinese medicine of the present invention is 210g crude drug/kg, by kg body weight, calculates, and is equivalent to 1110 times of Coming-of-Age Day consumption 8.8g, by body surface area, calculates, and is equivalent to 172 times; It is 41.567 crude drugs/kg that intraperitoneal administration records its LD50, its 95% credible 36.124～41.983g crude drug/kg that is limited to.Illustrate that Chinese medicine preparation oral toxicity of the present invention is low, clinical practice is safer.

Long term toxicity test:

Chinese medicine preparation of the present invention to mice by 7.81,18.34 and 12 weeks (1.0ml/100g body weight of 40.11g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 12 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Clinical experiment:

Clinical data: narrow patient's 60 examples of cardiovascular, be uncomfortable in chest, breathe hard, and angina pectoris, occasionally there is acute myocardial infarction.Wherein male's 34 examples, women's 26 examples, 35～72 years old age, average 58 years old.Inclusive criteria: underwent coronary radiography is made a definite diagnosis, at 35～72 years old age, male or female, meets following condition: 1. Acute myocardial infarction or stable type and unstable angina pectoris; 2. coronary angiography show 2 or 2 above Major Coronary 75 %～99 % narrow or inaccessible; have 1 applicable row percutaneous transluminal coronary stent implantation at least, and owing at least also having still exist >=more than 75 % narrow or inaccessible of 1 arteria coronaria blood vessel after a variety of causes Stent; 3. the 0mm of lesion vessels diameter 2. 5～4., and do not go in the past percutaneous tranluminal coronary angioplasty (PTCA); 4. implanting coronary artery bracket is non-bracket for eluting medicament, length≤25 mm; 5. without aspirin, heparin, Plavix contraindication.Exclusion standard: 1. complication with diabetes; 2. severe cardiac functional defect, cardiac function IV level; 3. acute upper respiratory tract infection; 4. malignant tumor; 5. Coronary Artery Lesions length of vessel > 25 mm; 6. arteria coronaria bifurcated lesions; 7. row aorta 2 coronary artery bypass graftings (CABG).At random patient is divided into treatment group 30 example and matched group 30 examples.

1 control methods:

Two groups of patients apply fat regulation medicine, anticoagulant, platelet receptor blocker, nitrate esters, β 2 blocker, calcium ion blocker, angiotensin-convertion enzyme inhibitor, Angiotensin Ⅱ receptor antagonist etc. as Primary Care according to the equal routine of the state of an illness.After Stent in 24 h, treatment group gives Chinese medicine capsules of the present invention every day three times, each two; Matched group only adopts Primary Care.Be 6 months two groups of patients' the course for the treatment of.

1.2 observation index and method

Arteria coronaria side shoot integration: adopt blood vessel Digital Subtraction to detect arteria coronaria collateral circulation.Arteria coronaria side shoot is according to international Cohen2Rentrop method method [1]: 0=without any collateral blood vessels; 1=there is collateral blood vessels to be poured but do not arrive visceral pericardium part; 2=collateral blood vessels is partly filled into visceral pericardium; 3=collateral blood vessels is filled into visceral pericardium completely.If any a plurality of side shoots, point out higher integration; If any several branch vessel pathological changes, exist many places side shoot to select 1 branch vessel that integration is higher to calculate.

Ejection fraction (ejection fraction, EF): use two dimensional echocardiogram machine, adopt and revise Simpson formula measurement EF.

Statistical procedures: application SPSS 11. 0 statistical softwares carry out variance analysis, t check and χ ²check.

2 results

2. 1 arteria coronaria collateral circulation integration and ET change while being selected in, two groups of patients all have less collateral circulation even there is no collateral circulation, but treatment group patient was through the treatment of 6 months, arteria coronaria collateral circulation integration minute is brought up to (2. 05 ± 0. 1) minute by (0. 12 ± 0. 10), and ET is also improved, by (0. 46 ± 0. 24), bring up to (0. 51 ± 0. 22), and matched group arteria coronaria collateral circulation integration only minute is brought up to (1. 40 ± 0. 11) minute by (0. 13 ± 0. 12), before ET treatment, be (0. 45 ± 0. 21), after treatment, be (0. 44 ± 0. 22), arteria coronaria collateral circulation integration after treatment group patient treatment all has significant differences (P < 0. 01) with matched group before treating, and ET has significant difference (P < 0. 05), arteria coronaria collateral circulation integration before and after treatment of control group and ET be there was no significant difference (P > 0. 05).

2. 2 tube chambers and stent restenosis change treatment group patient's minimum lumen diameter and luminal stenosis percentage rate and matched group comparison there are no significant difference (P > 0. 05), see the following form.

The variation (.x ± s) of luminal stenosis before and after two groups of patient treatments

Project	Treatment group (n=30)	Matched group (n=30)
			Minimum pipe diameter (mm)	?	?
Vascularization is preoperative	1. 11±0. 43	1. 13 ±0. 48
			After 6 months	1. 97?±0. 74	2. 08?±0. 59
With reference to lumen diameter (mm)	?	?
			Angiopoiesis is preoperative	2. 92±0. 45	2. 93 ±0. 46
After 6 months	2. 95?±0. 44	2. 78 ±0. 42
			Luminal stenosis percentage rate (%)	?	?
Angiopoiesis is preoperative	61. 21?±16. 00	60.59?±14. 00
			After 6 months	3. 00 ±1. 00	26. 00 ±16. 00
Clinical stenosis incidence rate (%)	10. 00	9. 68

Embodiment 1:

Make pottery certain, man, 69 years old, have hypertension history, because angina pectoris is in hospital, angina pectoris is a burst of youngster a little while, breathes hard uncomfortable in chest, Electrocardioscopy has myocardial ischemia.Do cardia catheterization, its right coronary artery corner has stopped up percent 70%.At right descending branch, blocked up 55%, in convolution, blocked up 65%, at opening part, blocked up 50%.Take following prescription:

Fructus Crataegi 20g, Radix Polygoni Multiflori 20g, Spica Prunellae 20g, Semen Vaccariae 15g, Olibanum 15g, Myrrha 15g, Herb Gynostemmae Pentaphylli 15g, Radix Paeoniae Alba 15g, Radix Angelicae Sinensis 15g, Lentinus Edodes 15g, Herba Dendrobii 10g, Radix Asparagi 10g, Radix Polygalae 10g, Fructus Toosendan 10g, Radix Codonopsis 15g, Moschus 10g, Radix Glycyrrhizae 8g.

Be decocted in water for oral dose and take, every day, potion, took at twice on the 1st, within 7 days, was a course for the treatment of.Take after 6 courses for the treatment of, sensation of oppression over the chest with shortness of breath, these symptoms of angina pectoris significantly alleviate, cardia catheterization, its right coronary artery corner has stopped up percent 25%.At right descending branch, blocked up 20%, in convolution, blocked up 30%, at opening part, blocked up 20%.This ratio is during compared with initial examination, and cardiovascular narrow problem is got through on a large scale, continues to take 10 courses for the treatment of, and electrocardiogram shows that myocardial ischemia problem improves substantially.

 

Embodiment 2:

Hu, man, 60 years old, coronary heart disease medical history 2 years, once because suffering from myocardial infarction died during hospitalization treatment, through thromboembolism treatment, observe, leave hospital after two months, still have breast vexed, breathe hard, the weak myocardial damage sign that waits, patient's long-term bed, can not Go to ground activity, aggravation after slightly movable, electrocardiogram prompting old heart infarction, and serious S-T section changes, cardiac ultrasonic points out left chamber systolic and diastolic function seriously to go down, radiography shows coronary atherosclerosis, cause blood vessel Serious Stenosis, and apply PTCA RS occurs later six months, turn Chinese traditional treatment, cut out Western medicine, change and take medicine pill prepared in accordance with the present invention, use following formula:

Fructus Crataegi 30g, Radix Polygoni Multiflori 30g, Spica Prunellae 30g, Semen Vaccariae 25g, Olibanum 25g, Myrrha 25g, Herb Gynostemmae Pentaphylli 25g, Radix Paeoniae Alba 25g, Radix Angelicae Sinensis 25g, Lentinus Edodes 25g, Herba Dendrobii 15g, Radix Asparagi 15g, Radix Polygalae 15g, Fructus Toosendan 15g, Radix Codonopsis 25g, Moschus 15g, Radix Glycyrrhizae 12g.

Take every day three times, each four, add the treatment of heartbeat health simultaneously, after 50 days, patient symptom is clearly better. and after treating 5 months, electrocardiogram S-T section often changes correction, cardiac ultrasonic shows that left chamber contractile function is normal, and platelet aggregation reduces, and suppresses the formation of thrombosis, reduce the stimulation to smooth muscle cell, further prevented restenosis after support.Continue to take consolidation in 40 days, not recurrence so far after drug withdrawal.

 

Embodiment 3:

Cao, 56 years old, female.Check Cervical Vessels.Ultrasonogaphic etudig: right carotid: internal diameter 7.7mm, intimal thickening, the about 2.4*0.9mm of the widest part scope.vamx：82.9cm/s，RI：0.77。CDFI blood flow signal is full good.Left common carotid: internal diameter 7.2mm, intimal thickening, the about 2.9*1.0mm of the widest part scope, the visible several pieces strong echo speckles of left common carotid crotch, the about 2.0mm of the greater, Vamx:56.2cm/s, RI:0.84.CDFI blood flow signal is full good.Check point: heart color Doppler, ventricular wall motion analysis, Determination of Left Ventricular Function.Heart: size: left chamber 44/29mm; The 17/12mm of right ventricle; Left ventricular outflow tract view 19mm; Outflow tract of right ventricle 20mm; Chamber wall thickness: left locular wall apex of the heart place ventricular wall motion is inharmonious, the width of fighting: normal; Interventricular septum (T/E) 10/8mm; LVPW (T/E) 9/7mm; Bicuspid valve: very thin, VE:0.35m/s, VA:0.90m/s, EF slope 63mm/s: aortic valve; Determination of Left Ventricular Function: SV:53ml, EF:61%, FS:32%, HR:76bpm, CO:4.0L/min.The visible anti-a fluid stream of Bicuspid valve, anti-flow area 0.9scm.Result: blood vessel Serious Stenosis, cause angina pectoris, heavy when light during angina pectoris, sensation of oppression over the chest with shortness of breath.Use following formula:

Fructus Crataegi 25g, Radix Polygoni Multiflori 25g, Spica Prunellae 25g, Semen Vaccariae 20g, Olibanum 20g, Myrrha 20g, Herb Gynostemmae Pentaphylli 20g, Radix Paeoniae Alba 20g, Radix Angelicae Sinensis 20g, Lentinus Edodes 20g, Herba Dendrobii 12g, Radix Asparagi 12g, Radix Polygalae 12g, Fructus Toosendan 12g, Radix Codonopsis 20g, Moschus 12g, Radix Glycyrrhizae 10g.

Be decocted in water for oral dose and take, every day, potion, took at twice on the 1st, within 7 days, was a course for the treatment of.Take after 8 courses for the treatment of, sensation of oppression over the chest with shortness of breath, these symptoms of angina pectoris significantly alleviate, catheterization, angiostenosis problem is greatly improved, and continues to take after 10 courses for the treatment of, and angina pectoris disappears, and indices is tending towards normal range value.

 

Embodiment 4:

Grandson, man, 71 years old, has angina pectoris, hypertension.Sign: have fever symptoms, still feel cardiopalmus after body temperature is normal, pulse speeds, and pareordia is uncomfortable, health fatigue and weak.Auxiliary examination: numeration of leukocyte raises, electrocardiographic abnormality, myocardial damage ST-T changes, and radiography shows coronary atherosclerosis, causes blood vessel Serious Stenosis, and applies PTCA.Postoperative generation RS, cuts out Western medicine to patient, turns Chinese traditional treatment, uses formula as follows:

Fructus Crataegi 22g, Radix Polygoni Multiflori 22g, Spica Prunellae 22g, Semen Vaccariae 18g, Olibanum 18g, Myrrha 18g, Herb Gynostemmae Pentaphylli 18g, Radix Paeoniae Alba 18g, Radix Angelicae Sinensis 18g, Lentinus Edodes 18g, Herba Dendrobii 11g, Radix Asparagi 11g, Radix Polygalae 11g, Fructus Toosendan 11g, Radix Codonopsis 18g, Moschus 11g, Radix Glycyrrhizae 9g.

Be decocted in water for oral dose and take, every day, potion, took at twice on the 1st, within 7 days, was a course for the treatment of.Take after 10 courses for the treatment of, sensation of oppression over the chest with shortness of breath, these symptoms of angina pectoris significantly alleviate, catheterization, angiostenosis problem is greatly improved, and continues to take after 15 courses for the treatment of, and angina pectoris disappears, and indices is tending towards normal range value.

 

Result shows: blockage of the cardiac vessels, the blood stasis of blood is stagnant is its Etiological, uses prescription supporting vital QI and dispersing blood stasis of the present invention, so blood circulation promoting and blood stasis dispelling should be the narrow fundamental law of control.The present invention has blood vessel dilating, blood pressure lowering, improves the effects such as microcirculation; The effect of excited heart, enhancing coronary blood flow and myocardial contraction, is used prescription of the present invention can effectively prevent RS.Proportioning of the present invention is simple, easy to use, promoting flow of QI and blood, the hypertrophy of inhibition smooth muscle cell; Prevent platelet aggregation, suppress the formation of thrombosis.

Claims (5)

1. treat the Chinese medicine that cardiovascular is narrow, it is characterized in that, comprise configure according to unit of weight as follows: Fructus Crataegi 20-30g, Radix Polygoni Multiflori 20-30g, Spica Prunellae 20-30g, Semen Vaccariae 15-25g, Olibanum 15-25g, Myrrha 15-25g, Herb Gynostemmae Pentaphylli 15-25g, Radix Paeoniae Alba 15-25g, Radix Angelicae Sinensis 15-25g, Lentinus Edodes 15-25g, Herba Dendrobii 10-15g, Radix Asparagi 10-15g, Radix Polygalae 10-15g, Fructus Toosendan 10-15g, Radix Codonopsis 15-25g, Moschus 10-15g, Radix Glycyrrhizae 8-12g.

2. treat according to claim 1 the Chinese medicine that cardiovascular is narrow, it is characterized in that, comprise configure according to unit of weight as follows: Fructus Crataegi 20-25g, Radix Polygoni Multiflori 20-25g, Spica Prunellae 20-25g, Semen Vaccariae 15-20g, Olibanum 15-20g, Myrrha 15-20g, Herb Gynostemmae Pentaphylli 15-20g, Radix Paeoniae Alba 15-20g, Radix Angelicae Sinensis 15-20g, Lentinus Edodes 15-20g, Herba Dendrobii 10-12g, Radix Asparagi 10-12g, Radix Polygalae 10-12g, Fructus Toosendan 10-12g, Radix Codonopsis 15-20g, Moschus 10-12g, Radix Glycyrrhizae 8-10g.

3. treat according to claim 1 the Chinese medicine that cardiovascular is narrow, it is characterized in that, comprise configure according to unit of weight as follows: Fructus Crataegi 25-30g, Radix Polygoni Multiflori 25-30g, Spica Prunellae 25-30g, Semen Vaccariae 20-25g, Olibanum 20-25g, Myrrha 20-25g, Herb Gynostemmae Pentaphylli 20-25g, Radix Paeoniae Alba 20-25g, Radix Angelicae Sinensis 20-25g, Lentinus Edodes 20-25g, Herba Dendrobii 12-15g, Radix Asparagi 12-15g, Radix Polygalae 12-15g, Fructus Toosendan 12-15g, Radix Codonopsis 20-25g, Moschus 12-15g, Radix Glycyrrhizae 10-12g.

4. treat according to claim 1 the Chinese medicine that cardiovascular is narrow, it is characterized in that, comprise configure according to unit of weight as follows: Fructus Crataegi 22-28g, Radix Polygoni Multiflori 22-28g, Spica Prunellae 22-28g, Semen Vaccariae 18-22g, Olibanum 18-22g, Myrrha 18-22g, Herb Gynostemmae Pentaphylli 18-22g, Radix Paeoniae Alba 18-22g, Radix Angelicae Sinensis 18-22g, Lentinus Edodes 18-22g, Herba Dendrobii 11-14g, Radix Asparagi 11-14g, Radix Polygalae 11-14g, Fructus Toosendan 11-14g, Radix Codonopsis 18-22g, Moschus 11-14g, Radix Glycyrrhizae 9-11g.

5. a preparation method for the Chinese medicine that as described in as arbitrary in claim 1-4, treatment cardiovascular is narrow, is characterized in that,

Dosage form is honey refining pill, and its preparation method comprises the following steps:

Described component is soaked 30 minutes to 1 hour, and heated and boiled 30 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, cooling after drying, and mixes and is twisted into slice, pill wax seal packing with Mel;

Dosage form is capsule, its preparation method comprises the following steps: each component is added to 10 times of amount ethanol of weight, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The adsorption resin column that described filtrate flow is 10L through volume, uses deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule;

Dosage form is tablet, and its preparation method comprises the following steps: the chopping of each component is joined in multi-function extractor, and adding ratio of weight and number is the water soaking 30～40 minutes of 3000 parts, decocts after 1.5 hours, takes out that decoction liquor is standby for the first time; It is that the decocting of 3000 parts boiled after 1 hour that medicinal residues add ratio of weight and number, take out decoction liquor for the second time, aforementioned twice decoction liquor merged and filtered, it is the solution of 1000 parts that filtrate decompression is concentrated into ratio of weight and number, staticly settle 24～36 hours, draw supernatant, add starch after being heated to 40～50 ℃, heating is concentrated into pasty state, put into baking oven, be controlled at 80 ℃, cooling after drying, film-making, dry, molding, subpackage;

Dosage form is drop pill, and its preparation method comprises the following steps: the water that each component is mixed and added its weight sum 5-7 doubly to measure, put into multi-function extractor, and keep air pressure at 0.04-0.06mPa, decoct 2 hours; Repeat above-mentioned steps and again extract 1.5 hours, extracting liquid filtering 100 mesh sieves; With the refining filtrate of adsorbent resin, with ethanol elution; Eluent is evaporated to density 1.33-1.35, input air pressure 0.04-0.06mPa wherein, and vacuum is-0.076 ~-0.088mPa, stand for standby use; Repeating abovementioned steps extracts 1 hour again; Extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate, to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitated liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure is 0.04-0.06mPa, vacuum is 0.076-0.088mPa; Use sephadex chromatography is refining, with ethanol elution; Eluent is concentrated into density and is 1.33-1.35, standing; Get above-mentioned two kinds of standing liquid and add PEG-4000, mix; Mixture heating and melting; With pill dripping machine, mixture is made to compound dripping pill.