CN104688915A - Drug for clearing liver heat and regulating menstruation and preparation method - Google Patents
Drug for clearing liver heat and regulating menstruation and preparation method Download PDFInfo
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Abstract
The invention discloses a drug for clearing liver heat and regulating menstruation. The drug is mainly prepared from the following raw medicines in parts by weight: 10 to 20 parts of prepared rehmannia root, 15 to 20 parts of radix paeoniae alba, 6 to 9 parts of madder, 9 to 12 parts of concha haliotidis, 10 to 20 parts of loranthus parasiticus, 8 to 16 parts of leonurus, 10 to 25 parts of eucommia ulmoides, 5 to 10 parts of campsis grandiflora, 9 to 16 parts of hairyvein agrimony, 5 to 10 parts of melastoma sanguineum, 9 to 16 parts of silybum marianum, 8 to 12 parts of sanguisorba officinalis (fried), 10 to 20 parts of trichosanthes kirilowii maxim, and 9 to 16 parts of radix boehmeriae. The drug has the effects of nourishing Yin and supplementing blood, calming the liver and tonifying kidney, and removing heat to cool blood, can effectively condition physical function of women, and improve the immunity of the organism. The drug has the advantages of being good in treatment effect, fast to act, safe and reliable.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of liver heat removing regulating menstruation medicament and preparation method.
Background technology
Menstruation, also known as making menstrual cycle, is physiological cycle period, occurs between some women with fertility and other hominids.After women adolesces, ovary is ripe gradually, and starts to secrete estrogen, and endometrium produces menstruation thereupon changing.The menstrual cycle of each women is not quite similar, and the first day from the first day of menstrual onset to next menstrual onset is called a menstrual cycle.Most people between 28-35 days, but also has a few peoples to be as short as 20 days or reaches 45 days one-periods, in above-mentioned scope, as long as menstruation is regular, all belongs to normal phenomenon.The length in menstrual period often varies with each individual, and from 2 to 8 days not etc., average terminates for 4,5 days.The menstrual blood loss of normal female menstrual phase is 30-120 milliliter, most at about 50 milliliters.Menoxenia, is a kind of common gynaecopathia, shows as the exception of menstrual cycle or amount of bleeding, or the moon is premenstrual, menstrual period time stomachache and General Symptoms.The cause of disease may be organic disease or malfunction.Many systemic diseases such as hematopathy, hypertension, hepatopathy, endocrinopathy, miscarriage, ectopic pregnancy, hydatidiform mole, reproductive tract infection, tumor (as ovarian tumor, hysteromyoma) etc. all can cause menoxenia.The traditional Chinese medical science is thought, menoxenia mechanism is that QI and blood is lost and causes menoxenia due to dysfunction of CHONG meridian in adjustment, and its cause of disease is many caused by irritability stasis or asthenia of renal qi.And based on stagnation of liver-QI, liver is the son of kidney, irritability stasis, catharsis is lacked of proper care, illness of child viscera affecting mother one, makes closing of kidney qi hide mistake department, therefore often develops into Liver and kidney with sick.Menoxenia can cause women to have a headache, and with dizzy, palpitation and sleeplessness, the symptoms such as spiritlessness and weakness.Menses run off in a large number and cause deficiency of both QI and blood.If can not treat in time, will be converted into periodically or other type comparatively obstinate headache or occur anemia phenomenon.Menoxenia also can cause mottle, skin sore etc.Menoxenia is likely infertile signal, and the reason of menoxenia is complicated and diversified, and the menoxenia that particularly organic reason causes can not get timely treatment, affects possibly and gives birth in the future.
Publication No. CN 102579695 A(application number 201210076985.7) Chinese patent literature disclose a kind of decoction for the treatment of menoxenia, composition comprise Flos Carthami 5-10 part, Cortex Phellodendri 5-15 part, Radix Rubiae 1-5 part, Radix Angelicae Dahuricae 3-8 part, Herba Leonuri 0.1-0.5 part, Herba Violae 3-10 part, Fructus Corni 5-10 part, Poria 3-8 part, Radix Angelicae Sinensis 5-10 part, Cortex Moutan 10-20 part and water 50-100 part.Publication No. CN 101843709 A(application number 200910235868.9) Chinese patent literature disclose a kind of Chinese medicine for the treatment of menoxenia, by Radix Paeoniae Rubra, Ganoderma, the Radix Rehmanniae, Herba Artemisiae Annuae, Radix Angelicae Sinensis, Radix Notoginseng, Herba Artemisiae Anomalae, Carapax Trionycis
Make Deng raw material.Publication No. CN 102824505 A(application number 201210316506.4) Chinese patent literature disclose a kind of Chinese medicine for the treatment of menoxenia, by Radix Ginseng 10g; Rhizoma Atractylodis Macrocephalae 15g; Radix Polygalae 10g; Semen Ziziphi Spinosae 15g; Arillus Longan 12g; Radix Rehmanniae Preparata 20g; Rhizoma Chuanxiong 15g; Herba Epimedii 12g; Rhizoma Dioscoreae 15g; Radix Notoginseng 6g; Colla Corii Asini 15g; Radix Glycyrrhizae 10g etc. makes.
At present, patient's many employings tcm therapy, because the traditional Chinese medical science treats to the ill, can reach the effect for the treatment of both the principal and secondary aspects of a disease, although Traditional Chinese Medicine formula is existing a lot, there is DeGrain, the shortcoming such as take effect slow more, therefore, the reliable traditional Chinese medical science formula of a kind of determined curative effect need be developed, solve existing issue.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, take safe liver heat removing regulating menstruation medicament and preparation.
Technical scheme of the present invention is:
A kind of liver heat removing regulating menstruation medicament, is prepared from primarily of following bulk drugs, is mass parts: Radix Rehmanniae Preparata 10-20, Radix Paeoniae Alba 15-20, Radix Rubiae 6-9, Concha Haliotidis 9-12, Herba Taxilli 10-20, Herba Leonuri 8-16, Cortex Eucommiae 10-25, Flos Campsis 5-10, Herba Agrimoniae 9-16, Radix Melastomatis Sanguinei 5-10, Herba Silybi mariani 9-16, Radix Sanguisorbae (stir-fry) 8-12, Fructus Trichosanthis 10-20 ， Radix Boehmeriae 9-16.
In preferred scheme, Radix Rehmanniae Preparata 12-18, Radix Paeoniae Alba 16-19, Radix Rubiae 7-8, Concha Haliotidis 10-11, Herba Taxilli 12-18, Herba Leonuri 10-14, Cortex Eucommiae 15-20, Flos Campsis 6-9, Herba Agrimoniae 10-15, Radix Melastomatis Sanguinei 6-9, Herba Silybi mariani 10-15, Radix Sanguisorbae (stir-fry) 9-11, Fructus Trichosanthis 12-18 ， Radix Boehmeriae 10-15.
Be more preferably, Radix Rehmanniae Preparata 15, the Radix Paeoniae Alba 17.5, Radix Rubiae 7.5, Concha Haliotidis 10.5, Herba Taxilli 15, Herba Leonuri 12, the Cortex Eucommiae 17.5, Flos Campsis 7.5, Herba Agrimoniae 12.5, Radix Melastomatis Sanguinei 7.5, Herba Silybi mariani 12.5, Radix Sanguisorbae (stir-fry) 10, Fructus Trichosanthis 15 ， Radix Boehmeriae 12.5.
The preparation method of described a kind of liver heat removing regulating menstruation medicament pill is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, pulverize and sieve together with step (1) (2) (3) made crude drug with the removing Radix Rehmanniae Preparata of impurity, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae, obtained medicated powder, add the Mel of medicated powder quality 1.2 times, stir while add Mel limit, pill block, rubbing, gradation, round, drying, obtains pill.
The preparation method of described a kind of liver heat removing regulating menstruation medicament pill, step (4) was pulverized 120-180 mesh sieve and (preferably, was pulverized 140-160 order; Be more preferably, pulverized 150 mesh sieves).
The preparation method of described decoction is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, put into after pot decocts with water 30 minutes, put into Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae and step (1) (2) (3) made crude drug, after being heated to boiling, make into little fire decoct 20-30 minute (preferred, make little fire into and decoct 22-28 minute; Be more preferably, make little fire into and decoct 25 minutes), filter, collect filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, turn little fire after adding water boil and decoct 20 minutes, Guan Huo, filter, merge with step (4) made filtrate, stir, obtain decoction.
The preparation method of described a kind of liver heat removing regulating menstruation medicament decoction, step (4) amount of water is that doubly (amount of water is 7-8 times of total raw material medicine quality to the 6-9 of total raw material medicine quality; Be more preferably, amount of water is 7.5 times of total raw material medicine quality).
The preparation method of described electuary is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, put into pot and add up the soak by water of crude drug quality 7.5 times after 30 minutes, put into Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae and step (1) (2) (3) made crude drug, after being heated to boiling, make into little fire decoct 20-30 minute (preferred, make little fire into and decoct 22-28 minute; Be more preferably, make little fire into and decoct 25 minutes), filter, collect filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, turn little fire after adding water boil and decoct 20 minutes, filter, repeat decoction twice, the filtrate obtained by collecting by filtration and step (4) made filtrate merge, and heating is concentrated, and lyophilization, pulverizes and sieves together with sucrose, obtains electuary.
The preparation method of described a kind of liver heat removing regulating menstruation medicament electuary, step (5) was pulverized 80-120 mesh sieve and (preferably, was pulverized 90-110 mesh sieve; Be more preferably, pulverized 100 mesh sieves).
The preparation method of described capsule is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, pulverize 120-180 mesh sieve with the removing Radix Rehmanniae Preparata of impurity, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-frys), Fructus Trichosanthis, Radix Boehmeriae together with step (1) (2) (3) made crude drug and (preferably, pulverize 140-160 order; Be more preferably, pulverized 150 mesh sieves), obtained medicated powder, adds adjuvant, soft material processed, granule processed, and dry, granulate, incapsulates, and obtains capsule.
The preparation method of described a kind of liver heat removing emmenagogue agent capsules agent, heavy 0.3-0.5g(is preferred for step (4) capsule every, the heavy 0.4g of capsule every).
A kind of liver heat removing regulating menstruation medicament provided by the invention, adopt differential diagnosis in tcm to treat, Scientific Usage of Drugs, through studying for many years, develops meticulously.In addition, excellent results of the present invention also shows:
1, the present invention has the effects such as nourishing YIN and supplementing blood, suppressing the hyperactive liver the kidney invigorating, clearing away heat and cooling blood, effectively can regulate female body function, enhancing human body immunity power;
The advantages such as 2, products made thereby of the present invention has good effect, instant effect, safe and reliable.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1a kind of liver heat removing regulating menstruation medicament, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Rehmanniae Preparata 10 parts, the Radix Paeoniae Alba 15 parts, 6 parts, Radix Rubiae, Concha Haliotidis 9 parts, Herba Taxilli 10 parts, Herba Leonuri 8 parts, the Cortex Eucommiae 10 parts, Flos Campsis 5 parts, Herba Agrimoniae 9 parts, Radix Melastomatis Sanguinei 5 parts, Herba Silybi mariani 9 parts, Radix Sanguisorbae (stir-fry) 8 parts, Fructus Trichosanthis 10 Fen ， Radix Boehmeriae 9 parts.
The preparation method of above-mentioned a kind of liver heat removing regulating menstruation medicament pill is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, 150 mesh sieves were pulverized together with step (1) (2) (3) made crude drug with the removing Radix Rehmanniae Preparata of impurity, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae, obtained medicated powder, add the Mel of medicated powder quality 1.2 times, stir while add Mel limit, pill block, rubbing, gradation, round, drying, obtains pill.
embodiment 2a kind of liver heat removing regulating menstruation medicament, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Rehmanniae Preparata 20 parts, the Radix Paeoniae Alba 20 parts, 9 parts, Radix Rubiae, Concha Haliotidis 12 parts, Herba Taxilli 20 parts, Herba Leonuri 16 parts, the Cortex Eucommiae 25 parts, Flos Campsis 10 parts, Herba Agrimoniae 16 parts, Radix Melastomatis Sanguinei 10 parts, Herba Silybi mariani 16 parts, Radix Sanguisorbae (stir-fry) 12 parts, Fructus Trichosanthis 20 Fen ， Radix Boehmeriae 16 parts.
A kind of preparation method of liver heat removing regulating menstruation medicament decoction is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, put into pot and add up the soak by water of crude drug quality 7.5 times after 30 minutes, put into Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae and step (1) (2) (3) made crude drug, after being heated to boiling, make little fire into and decoct 25 minutes, filter, collect filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, turn little fire after adding water boil and decoct 20 minutes, Guan Huo, filter, merge with step (4) made filtrate, stir, obtain decoction.
Model case: xxx, female, 26 years old.Main suit: prolong through after date, many through measuring, color is light red and matter is rare, intermenstrual period lusterless complexion, spiritlessness and weakness, shortness of breath and palpitation, medical check, thin white fur of tongue, pale tongue, and thready and weak pulse is diagnosed as deficiency of qi and blood type menoxenia.Take Chinese medicine conditioning, cure latter three months, once more occur prolonging through after date.
Take a kind of liver heat removing regulating menstruation of the present embodiment gained medicament decoction, every day 3 times, each 200-250ml(is warm), 20 days courses for the treatment of, menstrual period cut out.After taking two courses for the treatment of, substantially recover menstrual period normal, color is red, matter thickening, and malaise symptoms disappears, and after taking three courses for the treatment of, patient recovers normally menstrual period, and patient fully recovers, and follows up a case by regular visits to, do not recur after half a year.
embodiment 3a kind of liver heat removing regulating menstruation medicament, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Rehmanniae Preparata 12 parts, the Radix Paeoniae Alba 16 parts, 7 parts, Radix Rubiae, Concha Haliotidis 10 parts, Herba Taxilli 12 parts, Herba Leonuri 10 parts, the Cortex Eucommiae 15 parts, Flos Campsis 6 parts, Herba Agrimoniae 10 parts, Radix Melastomatis Sanguinei 6 parts, Herba Silybi mariani 10 parts, Radix Sanguisorbae (stir-fry) 9 parts, Fructus Trichosanthis 12 Fen ， Radix Boehmeriae 10 parts.
A kind of preparation method of liver heat removing regulating menstruation medicament electuary is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, put into pot and add up the soak by water of crude drug quality 7.5 times after 30 minutes, put into Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae and step (1) (2) (3) made crude drug, after being heated to boiling, make little fire into and decoct 25 minutes, filter, collect filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, turn little fire after adding water boil and decoct 20 minutes, filter, repeat decoction twice, the filtrate obtained by collecting by filtration and step (4) made filtrate merge, and heating is concentrated, lyophilization, pulverized 100 mesh sieves, obtained electuary together with sucrose.
Model case: xxx, female, 21 years old.Main suit: menstrual cycle indefinite existing half a year, through amount also more or less, dark menses is mingled with little clot, menstruation fore udder distending pain, lower abdomen paroxysmal pain, through period appetite decline, belch, medical check tongue fur BOHUANG, thready and rapid pulse, is diagnosed as caused by hepatic stagnation qi stagnation menoxenia.
Take a kind of liver heat removing regulating menstruation of the present embodiment gained medicament electuary, adopt every day three times, each 1 bag of about 4g, with warm boiled water, 20 days courses for the treatment of, intermenstrual period cuts out.After taking a course for the treatment of, patient pain disappears, and after taking two courses for the treatment of, patient's cycle stability and normal, also normal through amount, color is red, without clot, after taking three courses for the treatment of, patient menstrual period, menstrual cycle, all normal through amount, patient's recovery from illness.
embodiment 4a kind of liver heat removing regulating menstruation medicament, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Rehmanniae Preparata 18 parts, the Radix Paeoniae Alba 19 parts, 8 parts, Radix Rubiae, Concha Haliotidis 11 parts, Herba Taxilli 18 parts, Herba Leonuri 14 parts, the Cortex Eucommiae 20 parts, Flos Campsis 9 parts, Herba Agrimoniae 15 parts, Radix Melastomatis Sanguinei 9 parts, Herba Silybi mariani 15 parts, Radix Sanguisorbae (stir-fry) 11 parts, Fructus Trichosanthis 18 Fen ， Radix Boehmeriae 15 parts.
The preparation method of a kind of liver heat removing emmenagogue agent capsules agent is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, 150 mesh sieves were pulverized together with step (1) (2) (3) made crude drug with the removing Radix Rehmanniae Preparata of impurity, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae, obtained medicated powder, adds adjuvant, soft material processed, granule processed, drying, granulate, incapsulates, the heavy 0.4g of capsule every, obtains capsule.
Model case: xxx, female, 32 years old.Main suit: over nearly three months, menstrual blood volume showed increased, and many with the dim clot of purple, lower abdomen is ice-cold, distending pain, sore waist and aching in the waist and the back, dizziness, loose stool, poor appetite, medical check, and tongue limit purple is dim, white and thin fur, and deep and hesitant pulse is diagnosed as qi stagnation and blood stasis type menoxenia.
Take the agent of a kind of liver heat removing emmenagogue of the present embodiment gained agent capsules, adopt every day 3 times, each 4-6 grain, with warm boiled water, 20 days courses for the treatment of, intermenstrual period cuts out.After taking a course for the treatment of, patient is through measuring obvious minimizing, and clot reduces, and complexion changed is red, and lower abdomen sense of discomfort alleviates, and appetite is normal, and after taking three courses for the treatment of, patient recovers normal through amount, and without clot, each malaise symptoms also complete incidence graph, patient fully recovers.
embodiment 5a kind of liver heat removing regulating menstruation medicament, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Rehmanniae Preparata 15 parts, the Radix Paeoniae Alba 17.5 parts, 7.5 parts, Radix Rubiae, Concha Haliotidis 10.5 parts, Herba Taxilli 15 parts, Herba Leonuri 12 parts, the Cortex Eucommiae 17.5 parts, Flos Campsis 7.5 parts, Herba Agrimoniae 12.5 parts, Radix Melastomatis Sanguinei 7.5 parts, Herba Silybi mariani 12.5 parts, Radix Sanguisorbae (stir-fry) 10 parts, Fructus Trichosanthis 15 Fen ， Radix Boehmeriae 12.5 parts.
A kind of preparation method of liver heat removing regulating menstruation medicament pill is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, 150 mesh sieves were pulverized together with step (1) (2) (3) made crude drug with the removing Radix Rehmanniae Preparata of impurity, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae, obtained medicated powder, add the Mel of medicated powder quality 1.2 times, stir while add Mel limit, pill block, rubbing, gradation, round, drying, obtains pill.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Rehmanniae Preparata: base is former: for the rhizome of Radix Rehmanniae is celebrated in scrophulariaceae rehmannia glutinosa plant or bosom, steam solarization through processing and form.Nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
The Radix Paeoniae Alba: base is former: be the dry root of ranunculaceae plant Radix Paeoniae.Nature and flavor: bitter, sour, are slightly cold.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Rubiae: base is former: be the root welding technology of Maguireothamnus speciosus Radix Rubiae.Nature and flavor: bitter, cold.Gui Jing: return Liver Channel.Function cures mainly: removing heat from blood and promoting blood circulation, and blood stasis dispelling stimulates the menstrual flow.For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stay the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.Join Os Sepiae hemostasis power stronger.
Concha Haliotidis: base is former: the shell of Bao Ke animal Haliotis diversicolor (at the bottom of light sea certainly), haliotis discus hannai Ino (sea at the bottom of hair certainly), sheep Bao (sea certainly), haliotis ruber, Er Bao or white Bao.Nature and flavor: salty are flat.Gui Jing: enter liver, kidney channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.Control wind-yang and up-boring, headache, dizzy, frightenedly to jerk, hectic fever due to YIN-deficiency consumptive fever, optic atrophy.
Herba Taxilli: base is former: be the branch and leaf of Loranthaceae plant Herba Visci, Herba Taxilli or loranthus yadoriki etc.Nature and flavor: bitter, sweet, flat.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.
Herba Leonuri: base is former: be the herb of labiate Herba Leonuri.Nature and flavor: bitter, pungent, are slightly cold.Gui Jing: return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
The Cortex Eucommiae: base is former: be the bark of the Eucommiaceae plant Cortex Eucommiae.Nature and flavor: sweet, temperature.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Flos Campsis: base is former: be the flower of Bignoniaceae plant Radix campsis.Nature and flavor: sweet, sour, cold.Gui Jing: return liver, pericardium channel.Function cures mainly: removing heat from blood, and blood stasis dispelling is dispeled the wind.For menoxenia, Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.
Herba Agrimoniae: base is former: be the herb of rosaceous plant Agrimony.Nature and flavor: toil are flat.Gui Jing: enter lung, liver, spleen channel.Function cures mainly: hemostasis, stomach invigorating.Control spitting of blood, spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.
Radix Melastomatis Sanguinei: base is former: be root, the leaf of Herba Melastomatis Candii kind of plant Radix Melastomatis Sanguinei.Nature and flavor: bitter in the mouth, puckery, cool in nature.Gui Jing: return spleen, Liver Channel.Function cures mainly: removing toxic substances pain relieving, promoting regeneration of the tissue and arresting bleeding.Main eruptive disease stomachache, dysentery, has blood in stool, menorrhagia, furuncle, treating swelling and pain by traumatic injury, traumatic hemorrhage.
Herba Silybi mariani: base is former: be herb and the achene of feverfew Herba Silybi mariani.Nature and flavor: cold in nature, bitter in the mouth.Function cures mainly: herb is used for abscess and erysipelas; Fruit and extract are used for hepatopathy, spleen sick cholelithiasis, jaundice and chronic cough.
Radix Sanguisorbae (stir-fry): base is former: be the root and rhizome of Flos Rosae Multiflorae kind of plant Radix Sanguisorbae.Radix Sanguisorbae preparata: get Radix Sanguisorbae sheet and put in pot to fry and become strong yellow to coat, take out, dry.Nature and flavor: picric acid, cold.Gui Jing: enter liver, large intestine channel.Function cures mainly: blood on removing heat from blood, heat-clearing and toxic substances removing.Control haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.
Fructus Trichosanthis: base is former: be the fruit of cucurbitaceous plant Fructus Trichosanthis.Nature and flavor: cold in nature, sweet in the mouth, micro-hardship.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, intestine moistening.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and acute mastitis, lung abscess, acute appendicitis swell and ache.
Radix Boehmeriae: base is former: be the root of contrayerva Boehmeria.Nature and flavor: cold in nature, sweet in the mouth.Gui Jing: 1. " must book on Chinese herbal medicine be joined ": " enter meridian of Foot-JUE YIN blood system." 2. " book on Chinese herbal medicine brief points ": " staff, meridian of Foot-TAI YIN." function cures mainly: clearing away heat and promoting diuresis, antiabortive hemostasis, removing toxic substances.Swell and ache for cold, fever, measles hyperpyrexia, urinary tract infection, oedema due to nephritis, anemia of pregnant woman's stomachache, frequent fetal movement, threatened abortion, traumatic injury, fracture, skin infection, hemorrhage.
test example 1the clinical practice of a kind of liver heat removing regulating menstruation medicament (embodiment 5) of gained of the present invention:
In March ,-2014 in June, 2013, in the menoxenia patient that hospital outpatient is accepted for medical treatment, filter out 453 routine women's cases, age 15-42 year, 25.8 ± 2.4 years old mean age, the course of disease 4 months-3 years, average course of disease 1.1 ± 0.3 years.Wherein preceeded menorrhea 96 example, delayed menstrual cycle 56 example, menstruation is irregular 64 examples successively, dysmenorrhea 87 example, amenorrhea 52 example, excessive menstruation 45 example, very few 53 examples of menstrual blood volume.Diagnostic criteria and exclusion standard are all standard according to the guideline of clinical investigations of menoxenia " new Chinese medicine treatment " and " Gynecology of Chinese Medicine ", " obstetrics and gynecology ".
Patient is divided into two groups at random, experimental group and matched group, two groups in age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, taken three times a day, each 4-7 grain (adjusting to some extent depending on concrete condition), and 20 days courses for the treatment of, matched group takes other medicine (Herba Leonuri is by conventional medication such as capsule, WUJI BAIFENG WAN, seed pill for curing menoxenia).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.Detect the index such as liver function, renal function, electrocardiogram, routine blood test, clotting time and bleeding time, routine urinalysis before and after all subject.
The criterion of curative effect situation: cure: clinical symptom disappearance, menstrual period, through amount and menstrual cycle all recover normal; Effective: clinical symptoms is obviously alleviated, menstrual period, through amount and menstrual cycle all obviously improve; Invalid: malaise symptoms is unchanged, menstrual period, through amount and menstrual cycle all without improve.
Table 1 liang group patient treatment outcome
As shown in Table 1: in experimental group, the patient that menoxenia is cured has 196 examples (65.8%), and malaise symptoms is clearly better, menstruation be improved significantly patient 95 example (31.9%), experimental group total effective rate 97.7%.The cure rate of matched group and effective percentage are respectively 41.9% and 34.2%, and total effective rate is 76.1%, and successful is lower than experimental group.
The index such as liver function, renal function, electrocardiogram, routine blood test, clotting time and bleeding time, routine urinalysis before and after the treatment of both detections experimenter, find before and after treatment without significant change (
p> 0.05), and all within normal range.
The present invention have selected the Radix Rehmanniae Preparata of nourishing YIN and supplementing blood, the Radix Paeoniae Alba of suppressing the hyperactive liver pain relieving, the Radix Rubiae of removing heat from blood and promoting blood circulation, the Concha Haliotidis of liver heat removing and eyesight improving, the Herba Taxilli of invigorating the liver and kidney, the Herba Leonuri of promoting blood flow to regulate menstruation, the Cortex Eucommiae of invigorating the liver and kidney, the Flos Campsis of cooling blood, expelling wind, the Herba Agrimoniae of hemostasis stomach invigorating, the Radix Melastomatis Sanguinei of promoting regeneration of the tissue and arresting bleeding, the charred Radix Sanguisorbae of heat-clearing and toxic substances removing, the Radix Boehmeriae of clearing away heat and promoting diuresis, multiple effective medical material is also used, good curative effect is all shown for polytype menoxenia, plays the effects such as nourishing YIN and supplementing blood, suppressing the hyperactive liver the kidney invigorating, clearing away heat and cooling blood.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. a liver heat removing regulating menstruation medicament, is characterized in that, is prepared from primarily of following bulk drugs, be mass parts: Radix Rehmanniae Preparata 10-20, Radix Paeoniae Alba 15-20, Radix Rubiae 6-9, Concha Haliotidis 9-12, Herba Taxilli 10-20, Herba Leonuri 8-16, Cortex Eucommiae 10-25, Flos Campsis 5-10, Herba Agrimoniae 9-16, Radix Melastomatis Sanguinei 5-10, Herba Silybi mariani 9-16, Radix Sanguisorbae (stir-fry) 8-12, Fructus Trichosanthis 10-20 ， Radix Boehmeriae 9-16.
2. a kind of liver heat removing regulating menstruation medicament as claimed in claim 1, it is characterized in that, Radix Rehmanniae Preparata 12-18, Radix Paeoniae Alba 16-19, Radix Rubiae 7-8, Concha Haliotidis 10-11, Herba Taxilli 12-18, Herba Leonuri 10-14, Cortex Eucommiae 15-20, Flos Campsis 6-9, Herba Agrimoniae 10-15, Radix Melastomatis Sanguinei 6-9, Herba Silybi mariani 10-15, Radix Sanguisorbae (stir-fry) 9-11, Fructus Trichosanthis 12-18, Radix Boehmeriae 10-15 is (preferred, Radix Rehmanniae Preparata 15, the Radix Paeoniae Alba 17.5, Radix Rubiae 7.5, Concha Haliotidis 10.5, Herba Taxilli 15, Herba Leonuri 12, the Cortex Eucommiae 17.5, Flos Campsis 7.5, Herba Agrimoniae 12.5, Radix Melastomatis Sanguinei 7.5, Herba Silybi mariani 12.5, Radix Sanguisorbae (stir-fry) 10, Fructus Trichosanthis 15, Radix Boehmeriae 12.5).
3. a kind of liver heat removing regulating menstruation medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, pulverize and sieve together with step (1) (2) (3) made crude drug with the removing Radix Rehmanniae Preparata of impurity, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae, obtained medicated powder, add the Mel of medicated powder quality 1.2 times, stir while add Mel limit, pill block, rubbing, gradation, round, drying, obtains pill.
4. the preparation method of a kind of liver heat removing regulating menstruation medicament pill as claimed in claim 3, is characterized in that, step (4) was pulverized 120-180 mesh sieve and (preferably, pulverized 140-160 mesh sieve; Be more preferably, pulverized 150 mesh sieves).
5. a kind of liver heat removing regulating menstruation medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, put into after pot decocts with water 30 minutes, put into Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae and step (1) (2) (3) made crude drug, after being heated to boiling, make into little fire decoct 20-30 minute (preferred, make little fire into and decoct 22-28 minute; Be more preferably, make little fire into and decoct 25 minutes), filter, collect filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, turn little fire after adding water boil and decoct 20 minutes, Guan Huo, filter, merge with step (4) made filtrate, stir, obtain decoction.
6. the preparation method of a kind of liver heat removing regulating menstruation medicament decoction as claimed in claim 5, is characterized in that, step (4) amount of water is that doubly (amount of water is 7-8 times of total raw material medicine quality to the 6-9 of total raw material medicine quality; Be more preferably, amount of water is 7.5 times of total raw material medicine quality).
7. a kind of liver heat removing regulating menstruation medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable electuary, its preparation method is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, put into pot and add up the soak by water of crude drug quality 7.5 times after 30 minutes, put into Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-fry), Fructus Trichosanthis, Radix Boehmeriae and step (1) (2) (3) made crude drug, after being heated to boiling, make into little fire decoct 20-30 minute (preferred, make little fire into and decoct 22-28 minute; Be more preferably, make little fire into and decoct 25 minutes), filter, collect filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, turn little fire after adding water boil and decoct 20 minutes, filter, repeat decoction twice, the filtrate obtained by collecting by filtration and step (4) made filtrate merge, and heating is concentrated, and lyophilization, pulverizes and sieves together with sucrose, obtains electuary.
8. the preparation method of a kind of liver heat removing regulating menstruation medicament electuary as claimed in claim 7, is characterized in that, step (5) was pulverized 80-120 mesh sieve and (preferably, pulverized 90-110 mesh sieve; Be more preferably, pulverized 100 mesh sieves).
9. a kind of liver heat removing regulating menstruation medicament as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Oryza glutinosa (amount of Oryza glutinosa is 1 times of Radix Rubiae quality) and add decocting after 20 minutes, filter, removing Oryza glutinosa, collects filtrate, Radix Rubiae is put into filtrate, soaks into, and takes out and puts into pot, when slow fire is fried to dry tack free, takes out, dries;
(2) Cortex Eucommiae to be pruned rough bark, puts into pot and mix thoroughly with the yellow wine of its quality 0.4 times, fry to fracture of wire with moderate heat, surperficial burned black time, take out, spread out, dry in the air cool;
(3) get and pick clean Herba Leonuri and yellow wine is mixed thoroughly, be then placed in pot, Steam by water bath thoroughly after, take out, dry;
(4) Concha Haliotidis brush is scrubbed clean, pulverize 120-180 mesh sieve with the removing Radix Rehmanniae Preparata of impurity, the Radix Paeoniae Alba, Herba Taxilli, Flos Campsis, Herba Agrimoniae, Radix Melastomatis Sanguinei, Herba Silybi mariani, Radix Sanguisorbae (stir-frys), Fructus Trichosanthis, Radix Boehmeriae together with step (1) (2) (3) made crude drug and (preferably, pulverize 140-160 order; Be more preferably, pulverized 150 mesh sieves), obtained medicated powder, adds adjuvant, soft material processed, granule processed, and dry, granulate, incapsulates, and obtains capsule.
10. the preparation method of a kind of liver heat removing emmenagogue agent capsules as claimed in claim 9 agent, is characterized in that, heavy 0.3-0.5g(is preferred for step (4) capsule every, the heavy 0.4g of capsule every).
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| CN108403793A (en) * | 2018-05-10 | 2018-08-17 | 黑龙江中医药大学 | A kind of drug and its preparation method for treating primary dysmenorrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108403793A (en) * | 2018-05-10 | 2018-08-17 | 黑龙江中医药大学 | A kind of drug and its preparation method for treating primary dysmenorrhea |
| CN108403793B (en) * | 2018-05-10 | 2021-06-01 | 黑龙江中医药大学 | Medicine for treating primary dysmenorrhea and preparation method thereof |
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