CN105535342A - Medicinal preparation for secondary infertility caused by intrauterine adhesion - Google Patents

Medicinal preparation for secondary infertility caused by intrauterine adhesion Download PDF

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CN105535342A
CN105535342A CN201511000424.9A CN201511000424A CN105535342A CN 105535342 A CN105535342 A CN 105535342A CN 201511000424 A CN201511000424 A CN 201511000424A CN 105535342 A CN105535342 A CN 105535342A
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radix
pharmaceutical preparation
caulis
rhizoma cyperi
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刘树芹
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Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses a medicinal preparation for secondary infertility caused by intrauterine adhesion. The medicinal preparation is prepared from the following Chinese herbal medicine ingredients in parts by weight: 15 to 25 parts of epimedium herb, 10 to 20 parts of prepared rehmannia root, 10 to 20 parts of flatstem milkvetch seed, 10 to 20 parts of the seed of Chinese dodder, 20 to 30 parts of evergreen mucuna root and leaf, 8 to 18 parts of herba leonuri, 15 to 30 parts of triplostegia, 5 to 15 parts of radix dipsaci, 25 to 50 parts of beechey fig leaf, 10 to 20 parts of root of radix codonopsis, 8 to 18 parts of tangerine peel, and 8 to 18 parts of rhizoma cyperi. The medicinal preparation for secondary infertility caused by intrauterine adhesion has the efficacies of tonifying kidney and nourishing liver, strengthening spleen and stomach, clearing and activating channels and collaterals, replenishing essence and invigorating marrow, promoting circulation and removing stasis, and nursing Chong-Ren, and can be beneficial to improving the ovarian reserve function, improving ovarian blood supply, promoting ovarian formation and ovulation, improving the receptivity of endometrium, and providing the success rate of assisted reproduction.

Description

A kind of pharmaceutical preparation causing secondary infertility for intrauterine adhesion
Technical field
The invention belongs to the field of Chinese medicines, disclose a kind of pharmaceutical preparation causing secondary infertility for intrauterine adhesion.
Background technology
In recent years, along with the opening of people's attitude towards sex and generally postponing of childbearing age, before pregnant before marrige and fertility, the women of artificial abortion or drug induced abortion repeatedly constantly increases.There is menoxenia in the many women of Post operation, wherein some women generation hypomenorrhea, amenorrhea or infertile.Ju Ministry of Public Health statistics in 2004, China about has 7,000,000 routine artificial abortion every year, and real figure is far longer than this.
Recent studies finds infertile in artificial abortion, the clearing heat in the pericardium and to examine the morbidity after scraping on the high side, and common with Asherman syndrome.Modern medicine thinks that its immediate cause is caused by operation wound endometrium, particularly because negative pressure is too high, inhale palace overlong time, dilatation and curettage of uterine cross dark or when there being negative pressure suction nozzle repeatedly pass in and out palace mouth, perform the operation rough etc., all can cause the excessive damage of endometrium and orifice of uterus, cause hypomenorrhea, amenorrhea or infertile.In addition, the relative deficiency of ovarian hormone, also can make the reparation that impaired endometrium can not be perfect in time, thus add the chance of adhesion.
Hysteroscope is a kind of emerging gynecological of Wicresoft Clinics, is the sophisticated equipment that antithetical phrase intrauterine diseases carries out Diagnosis and Treat, can look at uterine cavity situation identification cicatrix straight, can make estimation to intrauterine adhesion position, scope and organization type.Accurately can decompose adhesion completely under direct-view, and surrounding normal inner membrance is seldom damaged, substantially increase accuracy and the treatment success rate of diagnosis.Intrauterine adhesion is caused to the patient of secondary infertility, the Adhesionlysis that adopts postoperative with Western medicine artificial cycle therapy for treating more clinically.Existing western medical treatment often toxic and side effects is comparatively large, and easily recurs after drug withdrawal, and therapeutic effect is unsatisfactory, and people usually seek help from Chinese medicine.The traditional Chinese medical science is thought, dilatation and curettage of uterine is hindered by golden sword repeatedly, or more than puerperal, blood is clean, and pathogen is taken advantage of a weak point, and uterus is appointed in the stagnant punching of the stasis of blood, or because of habitual abortion damage kidney qi, asthenia of essence and blood, and a sea of blood virtual loss is appointed in the punching of vessels of the uterus inanition, thus occurs hypomenorrhea, amenorrhea, the disease such as infertile.Chinese medicine has the feature of overall regulation and control, multisystem, too many levels, Mutiple Targets, is controlled, obviously can improve the clinical symptoms of patient, reach the object for the treatment of both the principal and secondary aspects of a disease by integral syndrome differentiation opinion.
Summary of the invention
Inventor combines theory and the clinical experience of oneself of the sage of the past at all times, by modern physiological pathology and pathogen and pathology of tcm, dialectically to combine with differential diagnosis of diseases, provide a kind of pharmaceutical preparation causing secondary infertility for intrauterine adhesion, it has life essence-filling, marrow-benefitting, the kidney invigorating nourishing the liver, blood circulation promoting and blood stasis dispelling, the effect of Chong and Ren Meridians regulating, can Ovary reserve be improved, improve the confession of ovary blood, promote ovary to be formed and ovulation, improve endometrial endometrial receptivity, the success rate of supplementary reproduction is provided.
The technical solution used in the present invention is as follows:
A kind of pharmaceutical preparation causing secondary infertility for intrauterine adhesion, it is made up of following medicinal raw material: Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Triplostegiae Grandiflorae, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Radix Codonopsis, Pericarpium Citri Reticulatae, Rhizoma Cyperi, and in side, the weight portion of each medicinal raw material is as follows:
Herba Epimedii 15-25 part, Radix Rehmanniae Preparata 10-20 part, Semen Astragali Complanati 10-20 part, Semen Cuscutae 10-20 part, Radix Seu Caulis Mucunae Sempervirentis 20-30 part, Herba Leonuri 8-18 part, Radix Triplostegiae Grandiflorae 15-30 part, Radix Dipsaci 5-15 part, Caulis et Folium Fici beecheyanae 25-50 part, Radix Codonopsis 10-20 part, Pericarpium Citri Reticulatae 8-18 part, Rhizoma Cyperi 8-18 part.
Fang Zhong: Herba Epimedii Xin Ganwen, kidney-replenishing, bone and muscle strengthening; The sweet tepor of Radix Rehmanniae Preparata, nourishing YIN and supplementing blood, beneficial essence fills out marrow; Semen Astragali Complanati temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs is monarch drug.The bitter temperature of Radix Seu Caulis Mucunae Sempervirentis, promoting blood flow to regulate menstruation, relaxing muscles and tendons of enriching blood; Herba Leonuri toil is slightly cold, promoting blood flow to regulate menstruation, inducing diuresis to remove edema, and two medicine compatibility Wen Han develop simultaneously, blood circulation promoting and blood stasis dispelling and just do not hinder, and promoting the circulation of blood is nourished blood and the stasis of blood is not stagnant, is ministerial drug.Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; The flat invigorating the liver and kidney of Semen Cuscutae and not dry; Radix Triplostegiae Grandiflorae blood-enriching qi-invigorating, tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation; Radix Dipsaci invigorating the liver and kidney, bone and muscle strengthening, mends continuous blood vessels, promoting flow of QI and blood muscles and bones; Caulis et Folium Fici beecheyanae invigorating middle warmer spleen invigorating, promoting blood circulation to remove obstruction in the collateral; The pungent energy of Rhizoma Cyperi fall apart, micro-hardship can be fallen, micro-sweet energy and, soothing the liver promoting QI circulation for relieving depression, QI and blood regulating, tool is adjuvant.All medicines close 5, the kidney invigorating nourishing the liver, invigorating the spleen and regulating the stomach, dredge the meridian passage, there are life essence-filling, marrow-benefitting, blood circulation promoting and blood stasis dispelling, the effect of Chong and Ren Meridians regulating, can Ovary reserve be improved, improve ovary blood and supply, promote ovary to be formed and ovulation, improve endometrial endometrial receptivity, the success rate of supplementary reproduction is provided.
Further preferably, cause a pharmaceutical preparation for secondary infertility for intrauterine adhesion, it is characterized in that being made up of the medicinal raw material of following weight: Herba Epimedii 18-23 part, Radix Rehmanniae Preparata 15-20 part, Semen Astragali Complanati 13-18 part, Semen Cuscutae 11-16 part, Radix Seu Caulis Mucunae Sempervirentis 25-30 part, Herba Leonuri 11-15 part, Radix Triplostegiae Grandiflorae 19-24 part, Radix Dipsaci 10-15 part, Caulis et Folium Fici beecheyanae 30-38 part, Radix Codonopsis 13-17 part, Pericarpium Citri Reticulatae 8-13 part, Rhizoma Cyperi 12-17 part.
Further preferably, cause a pharmaceutical preparation for secondary infertility for intrauterine adhesion, it is characterized in that being made up of the medicinal raw material of following weight: Herba Epimedii 20 parts, Radix Rehmanniae Preparata 15 parts, Semen Astragali Complanati 15 parts, Semen Cuscutae 12 parts, Radix Seu Caulis Mucunae Sempervirentis 27 parts, Herba Leonuri 12 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Dipsaci 12 parts, Caulis et Folium Fici beecheyanae 35 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Cyperi 15 parts.
The pharmacology activity research present situation of we's each medical material used is as follows.
Herba Epimedii: [nature and flavor] acrid, sweet, warm.[return through] returns liver, kidney channel.[function cures mainly]: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly]: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Semen Astragali Complanati: [nature and flavor] are sweet, temperature.[return through] returns liver, kidney channel.[function cures mainly] temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.
Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.This moral character is soft and moist, flat invigorating the liver and kidney and not dry.
Radix Seu Caulis Mucunae Sempervirentis: [nature and flavor] are bitter; Micro-hardship; Warm in nature.[return through] liver; Stomach warp.[function cures mainly] promoting blood flow to regulate menstruation; To enrich blood relaxing muscles and tendons.Main have through uncomfortable; Dysmenorrhea; Amenorrhea; Puerperal blood deficiency; Anemia; Rheumatic arthralgia; Numb limbs and tense tendons; Traumatic injury.
Herba Leonuri: [nature and flavor] are bitter, pungent, are slightly cold.[return through] returns liver, pericardium channel.[function cures mainly] promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Radix Triplostegiae Grandiflorae: [nature and flavor] sweet, micro-hardship is flat.[function cures mainly] tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, removing toxic substances.For lumbago due to renal deficiency, anemia, cough, seminal emission, sexual impotence, rheumatic arthritis, menoxenia, vicarious menstruation, metrorrhagia, leukorrhagia, infertility.External is stopped blooding.
Radix Dipsaci: [nature and flavor] are bitter, pungent, tepor.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Caulis et Folium Fici beecheyanae: [nature and flavor] are sweet; Light; Warm in nature.[return through] lung; Spleen; Kidney channel.[function cures mainly] invigorating middle warmer spleen invigorating; Wind-damp dispelling; Promoting blood circulation to remove obstruction in the collateral.The main deficiency of vital energy is weak; Extremity are aching and limp; Rheumatic arthralgia; Stiffness of the muscle and joint; Traumatic injury; Amenorrhea; Galactostasis.
Radix Codonopsis: [nature and flavor] are sweet is flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." book on Chinese herbal medicine justice ": " gas in strong fortune, this is very mutually not far away with Radix Ginseng for Radix Codonopsis power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting.Its outstanding valuable person, then spleen invigorating fortune and not dry, grow stomach-Yin and not wetting, lung moistening and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration and without just dry fraud.”
Pericarpium Citri Reticulatae: [nature and flavor] are bitter, pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
In order to express pharmaceutical preparation of the present invention better, pharmaceutical preparation of the present invention can be active component by Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Triplostegiae Grandiflorae, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Radix Codonopsis, Pericarpium Citri Reticulatae, Rhizoma Cyperi or its water or its extractive with organic solvent, this composition is independent or mix with medicine acceptable carrier, makes according to galenic pharmacy routine techniques.
Described pharmaceutically acceptable carrier, as mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Pharmaceutical preparation of the present invention is preferably made for peroral dosage form, as: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.
The peroral dosage form of pharmaceutical preparation further preferably described above is tablet, capsule or granule, most preferably is capsule.
Present invention also offers a kind of preparation method of pharmaceutical preparation described above, the present inventor finds under study for action, by optimized fabrication method, can when remaining valid medicine, remove impurity or the part without drug effect, reduce impurity to the interference of therapeutic effect, make this pharmaceutical preparation more effective, and reduce the consumption of medicine thus.
The preparation method of a kind of pharmaceutical preparation for secondary infertility caused by intrauterine adhesion provided by the invention, mainly comprises the following steps:
(1) Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Triplostegiae Grandiflorae, Radix Codonopsis, Pericarpium Citri Reticulatae and Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi ethanol extraction filtering residue are decocted with water secondary after merging, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.05 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, this composition is independent or mix with medicine acceptable carrier, makes pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
The present invention be inventor through repeatedly studying, progressively improve, the good pharmaceutical preparation of last successful a kind of curative effect, and demonstrated the curative effect of pharmaceutical preparation of the present invention by clinical case further, particulars is as described below:
1 data and method
1.1 physical data: all uterine cavities through hysteroscopic diagnosis are adhered and cause the routine patient of secondary infertility 87 and be my Out-patient Department patient of in January, 2012 ~ 2013 year May, are divided into Chinese drug-treated group 58 example at random, matched group 29 example by medical order.23 ~ 34 years old Chinese drug-treated group age, average 27.8 ± 3.6 years old; Wherein slight 10 examples of intrauterine adhesion, moderate 30 example, severe 18 example, companion's Hypomenorrhea patient 33 example, companion's amenorrhea patients 15 example; 23 ~ 35 years old matched group age, average 27.4 ± 3.5 years old; Wherein slight 6 examples of intrauterine adhesion, moderate 14 example, severe 9 example, companion's Hypomenorrhea patient 16 example, companion's amenorrhea patients 7 example; Chinese drug-treated group has uteroventral operation to comprise artificial abortion, the clearing heat in the pericardium, examine and scrape, get the medical history such as ring, chronic pelvic inflammatory disease 49 example, and matched group has above-mentioned medical history 25 example.Two groups, at clinical data no significant differences (P > 0.05) such as disease kind, classification, age, the course of disease, lesion degrees, have comparability.
1.2 diagnosis marks: have dilatation and curettage of uterine history, gynecilogical operation or gynecological infection history, show as Hypomenorrhea or amenorrhea, the visible uterine cavity scar tissue adherent distortion of Medical Imaging inspection, filling defect, conduit inserts at cervical canal place and is obstructed.
Classify according to adhesion degree: severe: involve uterine cavity > 3/4, Uterus wall adhesion or adhesive band plumpness, uterine cavity upper end and fallopian tube closure of openings; Moderate: involve uterine cavity 1/4 ~ 3/4, only adhesive band is formed, the adhesion of ametria wall, and uterine cavity upper end and fallopian tube opening portion are closed; Slight: to involve uterine cavity < 1/4, adhesive band is poor or very thin, and uterine cavity upper end and the adhesion of fallopian tube opening are very light or visible.
Intrauterine adhesion causes secondary infertility, and the diagnostic criteria of " Chinese medical disease Standardization of diagnosis and curative effect " of issuing with reference to State Administration of Traditional Chinese Medicine is drafted: all once had motherhood history, the interruption that continues more than 1 year, do not practise contraception and not conceived diagnosable be infertility.
1.3 get rid of mark: the secondary amenorrhea caused because of Other diseases; The physiologic amenorrheas such as gestation, suckling, menopause; Reproductive system birth defect and deformity; Because of the infertility that other reasons causes as ovulation failure, obstruction of fallopian tube etc.; Hormone therapy person is used in 3 months.
1.4 Therapeutic Method:
Application hysteroscopy inspection diagnosis, and classify according to intrauterine adhesion degree.Intrauterine adhesion carries out under being separated in direct-view of hysteroscope, for the operation under B ultrasonic monitoring of tough and tensile connective tissue adherence Separation.If postoperative treats 1 course for the treatment of, secondary amenorrhea, without improvement, can carry out rechecking operation, if desired row the 2nd exclusion.
After Chinese drug-treated group microscopy exclusion, capsule prepared by the oral embodiment of the present invention 1,2-4 grain, was a course for the treatment of with 3 months, took 6 months continuously every day; Matched group adopts estrogen and progestogen associating sequential therapy, oral estradiol valerate tablet (1mg/ grain, Bayer HealthCare Co), each 2mg, and every day 2 times, menstruation starts to take on the 5th day; Add dydrogesterone sheet after ovulation, each 10mg, every day 2 times, take 10 days, treat 6 months.
1.5 efficacy assessment standards: the complete separation criterion of hysteroscope: whole cavity of uterus recovers normal size and form, bilateral salpingo opening is shown clear.
Criterion of therapeutical effect: " the Chinese medical disease Standardization of diagnosis and curative effect " issued with reference to State Administration of Traditional Chinese Medicine is formulated, and cures: the person of becoming pregnant in 2 years; Effective: though do not become pregnant, the menoxenia symptom relevant with primary disease is improved, and check hysteroscope IUA part is formed again; Do not heal: do not become pregnant, menoxenia symptom is not improved, and IUA is formed again.
1.6 statistical methods: adopt SPSS16.0 statistical software to calculate.Each numerical value with represent, measurement data adopts t inspection, and enumeration data adopts χ 2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 liang of group patient comparitive study: Chinese drug-treated group compares with matched group total effective rate, and difference has statistical significance (P < 0.01), shows that Chinese drug-treated group therapeutic effect is better than matched group.In table 1.
Table 1 liang group patient comparitive study
Note: compare with matched group, * P < 0.01.
The untoward reaction of 2.2 liang of groups is compared: in therapeutic process, Chinese drug-treated group is without obvious adverse reaction.Nauseating 4 examples of matched group, poor appetite 8 example, uncomfortable 6 examples in gastral cavilty portion, dizziness 1 example, abnormal vaginal bleeding 4 example.Two groups are compared, and difference has statistical significance, and Chinese drug-treated group less adverse effect, patient compliance is better.
Found by treatment, uterine cavity is adhered the patient causing secondary infertility, and the medication cycle is long, and Western medicine side effect of taking medicine is large, and improves not obvious person to clinical symptoms, and Chinese drug-treated group treatment infertility has good therapeutic effect, and untoward reaction is few, has the advantage that Western medicine is incomparable.
Beneficial effect of the present invention: pharmaceutical preparation of the present invention has the kidney invigorating nourishing the liver, invigorating the spleen and regulating the stomach, dredge the meridian passage, has life essence-filling, marrow-benefitting, blood circulation promoting and blood stasis dispelling, the effect of Chong and Ren Meridians regulating; There is the feature of overall regulation and control, multisystem, too many levels, Mutiple Targets, controlled by integral syndrome differentiation opinion, obviously can improve the clinical symptoms of patient, research think may with adjustment hypothalamic-pituitary-ovarian axis, improve ovary to the reactivity of FSH, improve Ovary reserve, promote the blood circulation of ovary local, improve the confession of ovary blood, promote ovary to be formed and ovulation, also can improve endometrial endometrial receptivity simultaneously, the success rate of supplementary reproduction is provided.
The present invention is by correcting the equilibrium between yin and yang of kidney, taste should be taken into account simultaneously, essence and blood is abundant, and QI and blood is vigorous, logical mend suitable, be association of activity and inertia, evident in efficacy, patient compliance is better, and taking convenience, can alleviate patient's burden and misery effectively, the object for the treatment of both the principal and secondary aspects of a disease can be reached, and approved by extensive patients.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Herba Epimedii 20 parts, Radix Rehmanniae Preparata 15 parts, Semen Astragali Complanati 15 parts, Semen Cuscutae 12 parts, Radix Seu Caulis Mucunae Sempervirentis 27 parts, Herba Leonuri 12 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Dipsaci 12 parts, Caulis et Folium Fici beecheyanae 35 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Cyperi 15 parts.
Preparation method:
(1) Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Triplostegiae Grandiflorae, Radix Codonopsis, Pericarpium Citri Reticulatae and Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi ethanol extraction filtering residue are decocted with water secondary after merging, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.05 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, this composition is independent or mix with medicine acceptable carrier, makes capsule according to galenic pharmacy routine techniques.
The capsule that the present embodiment prepares, every containing crude drug 3.1g.
Embodiment 2
Prescription: Herba Epimedii 18 parts, Radix Rehmanniae Preparata 18 parts, Semen Astragali Complanati 18 parts, Semen Cuscutae 15 parts, Radix Seu Caulis Mucunae Sempervirentis 25 parts, Herba Leonuri 12 parts, Radix Triplostegiae Grandiflorae 22 parts, Radix Dipsaci 15 parts, Caulis et Folium Fici beecheyanae 30 parts, Radix Codonopsis 13 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Cyperi 12 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 3
Prescription: Herba Epimedii 23 parts, Radix Rehmanniae Preparata 18 parts, Semen Astragali Complanati 15 parts, Semen Cuscutae 15 parts, Radix Seu Caulis Mucunae Sempervirentis 28 parts, Herba Leonuri 15 parts, Radix Triplostegiae Grandiflorae 22 parts, Radix Dipsaci 10 parts, Caulis et Folium Fici beecheyanae 38 parts, Radix Codonopsis 16 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Cyperi 16 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 4
Prescription: Herba Epimedii 18 parts, Radix Rehmanniae Preparata 18 parts, Semen Astragali Complanati 15 parts, Semen Cuscutae 16 parts, Radix Seu Caulis Mucunae Sempervirentis 30 parts, Herba Leonuri 18 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Dipsaci 15 parts, Caulis et Folium Fici beecheyanae 25 parts, Radix Codonopsis 18 parts, Pericarpium Citri Reticulatae 13 parts, Rhizoma Cyperi 15 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 5
Prescription: Herba Epimedii 15 parts, Radix Rehmanniae Preparata 12 parts, Semen Astragali Complanati 12 parts, Semen Cuscutae 15 parts, Radix Seu Caulis Mucunae Sempervirentis 25 parts, Herba Leonuri 11 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Dipsaci 8 parts, Caulis et Folium Fici beecheyanae 40 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Cyperi 12 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 6
Prescription: Herba Epimedii 20 parts, Radix Rehmanniae Preparata 20 parts, Semen Astragali Complanati 13 parts, Semen Cuscutae 10 parts, Radix Seu Caulis Mucunae Sempervirentis 20 parts, Herba Leonuri 8 parts, Radix Triplostegiae Grandiflorae 24 parts, Radix Dipsaci 10 parts, Caulis et Folium Fici beecheyanae 50 parts, Radix Codonopsis 10 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Cyperi 12 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 7
Prescription: Herba Epimedii 25 parts, Radix Rehmanniae Preparata 20 parts, Semen Astragali Complanati 18 parts, Semen Cuscutae 15 parts, Radix Seu Caulis Mucunae Sempervirentis 25 parts, Herba Leonuri 14 parts, Radix Triplostegiae Grandiflorae 22 parts, Radix Dipsaci 15 parts, Caulis et Folium Fici beecheyanae 38 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Cyperi 12 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 8
Prescription: Herba Epimedii 20 parts, Radix Rehmanniae Preparata 15 parts, Semen Astragali Complanati 15 parts, Semen Cuscutae 12 parts, Radix Seu Caulis Mucunae Sempervirentis 27 parts, Herba Leonuri 12 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Dipsaci 12 parts, Caulis et Folium Fici beecheyanae 35 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Cyperi 15 parts.
Preparation method: Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80% by (1), each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Triplostegiae Grandiflorae, Radix Codonopsis, Pericarpium Citri Reticulatae and Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi ethanol extraction filtering residue are decocted with water secondary after merging, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.05 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, make tablet according to galenic pharmacy routine techniques.
Embodiment 9
Prescription: Herba Epimedii 20 parts, Radix Rehmanniae Preparata 15 parts, Semen Astragali Complanati 15 parts, Semen Cuscutae 12 parts, Radix Seu Caulis Mucunae Sempervirentis 27 parts, Herba Leonuri 12 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Dipsaci 12 parts, Caulis et Folium Fici beecheyanae 35 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Cyperi 15 parts.
Preparation method: Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80% by (1), each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Triplostegiae Grandiflorae, Radix Codonopsis, Pericarpium Citri Reticulatae and Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi ethanol extraction filtering residue are decocted with water secondary after merging, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.05 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, make granule according to galenic pharmacy routine techniques.

Claims (9)

1. cause a pharmaceutical preparation for secondary infertility for intrauterine adhesion, it is made up of following medicinal raw material: Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Triplostegiae Grandiflorae, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Radix Codonopsis, Pericarpium Citri Reticulatae, Rhizoma Cyperi.
2. pharmaceutical preparation as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight:
Herba Epimedii 15-25 part, Radix Rehmanniae Preparata 10-20 part, Semen Astragali Complanati 10-20 part, Semen Cuscutae 10-20 part, Radix Seu Caulis Mucunae Sempervirentis 20-30 part, Herba Leonuri 8-18 part, Radix Triplostegiae Grandiflorae 15-30 part, Radix Dipsaci 5-15 part, Caulis et Folium Fici beecheyanae 25-50 part, Radix Codonopsis 10-20 part, Pericarpium Citri Reticulatae 8-18 part, Rhizoma Cyperi 8-18 part.
3. pharmaceutical preparation as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight:
Herba Epimedii 18-23 part, Radix Rehmanniae Preparata 15-20 part, Semen Astragali Complanati 13-18 part, Semen Cuscutae 11-16 part, Radix Seu Caulis Mucunae Sempervirentis 25-30 part, Herba Leonuri 11-15 part, Radix Triplostegiae Grandiflorae 19-24 part, Radix Dipsaci 10-15 part, Caulis et Folium Fici beecheyanae 30-38 part, Radix Codonopsis 13-17 part, Pericarpium Citri Reticulatae 8-13 part, Rhizoma Cyperi 12-17 part.
4. pharmaceutical preparation as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following weight:
Herba Epimedii 20 parts, Radix Rehmanniae Preparata 15 parts, Semen Astragali Complanati 15 parts, Semen Cuscutae 12 parts, Radix Seu Caulis Mucunae Sempervirentis 27 parts, Herba Leonuri 12 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Dipsaci 12 parts, Caulis et Folium Fici beecheyanae 35 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Cyperi 15 parts.
5. the pharmaceutical preparation as described in as arbitrary in claim 1-4, is characterized in that preparation method mainly comprises the following steps:
(1) Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Herba Epimedii, Radix Rehmanniae Preparata, Semen Astragali Complanati, Semen Cuscutae, Radix Triplostegiae Grandiflorae, Radix Codonopsis, Pericarpium Citri Reticulatae and Radix Seu Caulis Mucunae Sempervirentis, Herba Leonuri, Radix Dipsaci, Caulis et Folium Fici beecheyanae, Rhizoma Cyperi ethanol extraction filtering residue are decocted with water secondary after merging, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.05 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, this composition is independent or mix with medicine acceptable carrier, makes pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
6. the pharmaceutical preparation as described in as arbitrary in claim 1-5, is characterized in that described pharmaceutical preparation is preferably made for peroral dosage form.
7. pharmaceutical preparation as claimed in claim 6, is characterized in that described peroral dosage form is preferably tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.
8. pharmaceutical preparation as claimed in claim 7, is characterized in that described peroral dosage form is preferably tablet, capsule or granule.
9. pharmaceutical preparation as claimed in claim 8, is characterized in that described peroral dosage form most preferably is capsule.
CN201511000424.9A 2015-12-28 2015-12-28 Medicinal preparation for secondary infertility caused by intrauterine adhesion Withdrawn CN105535342A (en)

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Application publication date: 20160504