CN105999155B - It is a kind of to treat the thin Chinese medicine of endometrium - Google Patents
It is a kind of to treat the thin Chinese medicine of endometrium Download PDFInfo
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- CN105999155B CN105999155B CN201610423601.2A CN201610423601A CN105999155B CN 105999155 B CN105999155 B CN 105999155B CN 201610423601 A CN201610423601 A CN 201610423601A CN 105999155 B CN105999155 B CN 105999155B
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Abstract
The thin Chinese medicine of endometrium is treated the invention discloses a kind of.It is mainly made of Radix Codonopsis, Gorgon fruit, cornu cerve degelatinatum, psoralea corylifolia, Herba Cistanches, Chinese yam, pulp of dogwood fruit, Radix Salviae Miltiorrhizae, Caulis Spatholobi, baked ginger, wine spirit rouge and radix glycyrrhizae preparata.The present invention is with above-mentioned bulk pharmaceutical chemicals prescription, and invigorating kidney, promoting blood circulation, born of the same parents are trained in replenishing essence, to enhance the endometrium thickness of women, increases menstrual flow, improves the ability for breeding fetus of women, and clinical treatment effective percentage is 97.78%.
Description
Technical field
The thin Chinese medicine of endometrium is treated the present invention relates to a kind of, belongs to technical field of traditional Chinese medicines.
Background technique
Cyclic Human Endometrium thickness can reflect inner membrance functional status, and endometrium is adequately proliferated and inwardly divides
Secrete one of the precondition that phase conversion is embryo's successful implantation.Measuring endometrium thickness by B ultrasound can reflect intimal proliferation
Situation is membrane stage essential condition in clinical judgment.Thin endometrium is women common disease, it is considered that Nv Xing
Under the action of having certain estrogen, the thickness that endometrium cannot reach 8 millimeters when doing ultrasonic examination is judged as endometrium
It is thin.
Endometrium is thin mainly to be made with age, history of artificial abortion, intrauterine surgical history, genital tuberculosis, ART related drugs
With inducing protocal, gene pleiomorphism etc. is related, and mechanism is mainly that estrogen receptor is reduced, and damage causes endometrium to be repaired
Multiple obstacle.Clinically some patient shows as that unknown cause endometrium is thin, and some researches show that may hinder with endometrial blood flow
Power increases, and the expression of vascular endothelial growth factor is lowered, so that Endometrial blood flow reduction is related.Thin common of endometrium
Symptom have menstrual period it is short, through the symptoms such as amount little or no amenorrhea, color is light red, have dizziness and tinnitus concurrently, waist soreness, talagia.
Drug or other treatment measure are mainly taken in the thin treatment of endometrium at present.Drug therapy is usually estrogen,
Low-dosage aspirin, Combined Pentoxifylline vitamin E, sildenafil citrate, granular cell colony stimulating factor, growth
Hormone etc., the generally existing side effect of said medicine and adverse reaction.Other treatment measure mainly includes imitative bioelectric stimulation, is done thin
Born of the same parents' treatment.The above method still lacks a large amount of clinical experiments have proved that needing further further investigated.Therefore Chinese medicine treatment because its green,
It is without side-effects, control the advantages that difficulty in relapse after healing, more and more paid attention to.
Summary of the invention
The present invention overcomes above-mentioned the deficiencies in the prior art, provides and a kind of treat the thin Chinese medicine of endometrium.The Chinese medicine
With 12 taste Chinese prescriptions, invigorating kidney, promoting blood circulation, born of the same parents are trained in replenishing essence, to enhance the endometrium thickness of women, increase menstrual flow, improve
The ability for breeding fetus of women.
The technical scheme is that a kind of treat the thin Chinese medicine of endometrium, characterized in that mainly by following weight parts
Bulk pharmaceutical chemicals be made: 10~20 parts of Radix Codonopsis, 10~20 parts of Gorgon fruit, 10~20 parts of cornu cerve degelatinatum, 10~20 parts of psoralea corylifolia, Herba Cistanches 10
~20 parts, 20~30 parts of Chinese yam, 10~20 parts of pulp of dogwood fruit, 10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of Caulis Spatholobi, 5~10 parts of baked ginger, wine
10~20 parts of clever rouge, 5~10 parts of radix glycyrrhizae preparata.
Optimum ratio: 15 parts of Radix Codonopsis, 15 parts of Gorgon fruit, 15 parts of cornu cerve degelatinatum, 15 parts of psoralea corylifolia, 12 parts of Herba Cistanches, 24 parts of Chinese yam,
15 parts of pulp of dogwood fruit, 18 parts of Radix Salviae Miltiorrhizae, 18 parts of Caulis Spatholobi, 6 parts of baked ginger, 15 parts of wine spirit rouge, 6 parts of radix glycyrrhizae preparata.
If patient has a sleepless night, 6 parts of Radix Polygalae, 10 parts of arillus longan can be added on the basis of former side.
Preparation and taking methods: water decocts, daily 1 dose, take in the morning and evening in two times.
Above-mentioned raw materials medicine further addition can also prepare various customary adjuvants required when different dosage forms, as excipient,
Corrigent, adhesive etc. are prepared into any common oral preparation with conventional method of Chinese medicinal, as granule, pill,
Capsule, tablet, oral solution etc..Preferably granule.
Preferably, granule of the present invention the preparation method comprises the following steps:
(1) 70% ethyl alcohol heating and refluxing extraction 2 is added in Radix Codonopsis, psoralea corylifolia, Herba Cistanches, pulp of dogwood fruit, Radix Salviae Miltiorrhizae and wine spirit rouge
It is secondary, 0.5~1 hour every time；Combined extract, after 200 mesh net filtrations, heating removes ethyl alcohol, obtains extracting solution；
(2) then by remaining 6 taste Chinese medicine (Gorgon fruit, cornu cerve degelatinatum, Chinese yam, Caulis Spatholobi, baked ginger and radix glycyrrhizae preparata) and step (1)
The dregs of a decoction merge, add water to cook 2 times, decoct 0.5~1.5 hour every time；Merge decoction liquor to obtain after 200 mesh net filtrations
Decoction liquor；
(3) merge step (1) extracting solution and step (2) decoction liquor, it is heated be concentrated into relative density be 1.20~
The thick paste of 1.30 (60 DEG C), the cane sugar powder that 1~3 times of quality is then added are uniformly mixed, are most pelletized and (suitably added when softwood processed afterwards
Enter a small amount of 70% ethyl alcohol), after dry, screening, be distributed into bag.
It is considered herein that: endometrium is thin to belong to Chinese medicine " hypomenorrhia ", " infertile " scope, and "Fu Qingzhu works on obstetric" proposes
" going out all kidneys through water " " through this in kidney " illustrates that menstruation needs generate under the adjusting of kidney.The generation of professor's Luo Yuankai discussion menstruation
It when mechanism, proposes "-uterus is appointed in kidney-day decyl- punching " Reproductive Axis, fills Sheng, whole body internal organs, qi and blood, warp what kidney qi, menses, punching were appointed
Under the mating reaction of network, uterus periodically hides the result let out and generated.If kidney qi is weak, kidney qi, which is lost, to exhaust, and menses is difficult to secrete to punching is appointed
Two arteries and veins are difficult to fill Sheng, and the source of uterus dystrophy, menses is deficient, then hypomenorrhia.Therefore inventors believe that disease treatment palpus kidney tonifying is living
Born of the same parents are trained in blood, replenishing essence.
Side's solution of the present invention is as follows:
Monarch drug in a prescription: Radix Codonopsis, Gorgon fruit, cornu cerve degelatinatum.The benefits of Radix Codonopsis has strengthening spleen and tonifying lung, enriches blood, promotes the production of body fluid.The kind energy supplementing the kidney to control the nocturnal of Gorgon fruit,
And there is the benefits of invigorating the spleen.Cornu cerve degelatinatum is tonified the kidney and support yang, and the property with convergence has the function of unsmoothing the sperm and stopping bleeding sore.Then qi and blood biochemistry is weary for spleen deficiency
Source, the kidney deficiency then debility of chong and ren channels, three medicines are monarch drug in a prescription altogether, and kidney and spleen invigorating, then qi and blood foot, rushes Ren Gu.
Ministerial drug: psoralea corylifolia, Herba Cistanches, Chinese yam, pulp of dogwood fruit.Psoralea corylifolia has a tonifying kidney and strengthening yang, astringent sperm contracting urine, it is warming spleen and stopping diarrha it
Function.Herba Cistanches are sweet in flavor to be mended, and sweet temperature is supporing yang, and matter profit is nourished, salty to enter kidney, be kidney-replenishing, the good medicine of benefiting essence-blood.Chinese yam has gas negative
Giving young employees remedial-courses in general knowledge and vocational skills, spleen, lung, kidney three it is dirty with mending the benefits of.Pulp of dogwood fruit is warm but not dry, mends without high, tonifies the liver and kidney, and strengthening the essence and can help
Sun, for the key medicine of flat tonifying yin sun.Said medicine tonifying liver spleen benefiting essence-blood, is altogether ministerial drug.The monarch and his subjects' phase 5, kidney tonifying, essence replenishing, warming kidney and enhancing yang.
Adjutant: Radix Salviae Miltiorrhizae, Caulis Spatholobi, baked ginger, excrementum pteropi.Radix Salviae Miltiorrhizae removing blood stasis for promoting tissue regeneration can break place blood, bushing blood without hurting just.Chicken
Blood rattan hardship is without dry, and temperature is without strong, and promoting circulation of blood dissipates the stasis of blood, and menstruction regulating and pain relieving, property is gentle, and and blood tonification effect.Baked ginger has warming channel for arresting bleeding
Function, the Materia Medica: " baked ginger is kept without walking ... warm Liver Channel, can go to dislike raw new, make Yin grows while yang is generating ... ".Wine spirit rouge has
The effect of promoting blood circulation and stopping pain, removing blood stasis and hemostasis.Activating microcirculation and removing stasis medicinal is played in medicine-feeding altogether, is gone to dislike the benefits of raw new, is closed saying for " kidney tonifying needing to invigorate blood circulation ", be altogether
Adjutant.
Make medicine: radix glycyrrhizae preparata coordinating the drug actions of a prescription.
Each raw material and effect
Radix Codonopsis: sweet in flavor, mild-natured, returns spleen, lung channel have strengthening spleen and tonifying lung, the benefits of enriching blood, promote the production of body fluid." materia medica " calls " tonifying spleen
Nourishing the stomach, moistening lung and producing body fluid are good for gas in fortune, this is not very mutually remote with ginseng ".
Gorgon fruit: Gorgon fruit is sweet puckery, convergence, be apt to can supplementing the kidney to control the nocturnal, and have the benefits of invigorating the spleen, Shennong's Herbal say its " ... mend
In, strengthening the essence gas ... ".
Cornu cerve degelatinatum: taste is salty, warm-natured, returns liver and kidney channel.Function: tonifying the kidney and support yang, and the property with convergence has unsmoothing the sperm and stopping bleeding sore
Function.
Psoralea corylifolia: it is bitter, pungent, it is warm-natured, return kidney, the spleen channel.There are tonifying kidney and strengthening yang, astringent sperm contracting urine, warming spleen and stopping diarrha function, " book on Chinese herbal medicine
Confucian classics " say: " psoralea corylifolia, can warming the kidney, raw sun in yin, the key medicine of sthenic fire benefit soil ".
Herba Cistanches: sweet in flavor to mend, sweet temperature is supporing yang, and matter profit is nourished, salty to enter kidney, is kidney-replenishing, the good medicine of benefiting essence-blood.
Chinese yam: it is sweet in flavor, it is mild-natured.Have a reinforcing both QI and YIN, spleen, lung, kidney three it is dirty with mending the benefits of, Shennong's Herbal Yan Qineng " is mended
In, benefiting energy, long muscle ".
Pulp of dogwood fruit: pulp of dogwood fruit acid, tepor, matter profit, property is warm but not dry, mends without high, tonifies the liver and kidney, can strengthening the essence and
Can be supporing yang, for the key medicine of flat tonifying yin sun." haigoushen " calls its " only the moon, water was indefinite, kidney tonifying gas, Xing Yangdao, replenishing essence marrow ... ".
Radix Salviae Miltiorrhizae: bitter, slightly cold, return heart, pericardium, Liver Channel.Removing blood stasis for promoting tissue regeneration can break place blood, bushing blood without hurting just." solar corona
Sub- book on Chinese herbal medicine " Yan Qineng " blood-nourishing sedate ... myogenic, which is put on flesh ... breaks place blood, mends new green blood, peaceful tire falls stillborn foetus ... ".
Caulis Spatholobi: bitter, micro-sweet, it is warm-natured, return liver kidney channel.Hardship is without dry, and for temperature without strong, promoting circulation of blood dissipates the stasis of blood, menstruction regulating and pain relieving, property
Matter is gentle, and and blood tonification effect.
Baked ginger: it is bitter, puckery, it is warm-natured.Returns spleen, Liver Channel.Have the function of warming channel for arresting bleeding, the Materia Medica: " baked ginger is kept without walking ...
Warm Liver Channel can go to dislike life newly, make Yin grows while yang is generating ... ".Baked ginger is that rhizoma zingiberis is fried to surface duskiness, interior forms in brown color.
Wine spirit rouge: bitter, salty, sweet, warm-natured, return liver warp.With promoting blood circulation and stopping pain, the effect of removing blood stasis and hemostasis.FAECES TROGOPTERORI with yellow rice wine: it takes net
Excrementum pteropi is set in pot, is heated with mild fire, is fried to there is stink smell spilling to take out immediately when color is yellow black, is uniformly sprayed quantitative Huang while hot
Wine is spread out and is dried.Excrementum pteropi every 100kg yellow rice wine 15kg.
Radix glycyrrhizae preparata: sweet and neutral.Return heart, lung, spleen, stomach meridian.Major function: tonifying spleen stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and the stomach,
Fatigue and weakness, severe palpilation, knotted pulse, detachable son poison.Radix glycyrrhizae preparata: extracting liquorice piece is fried to yellow to buff, no according to bake with honey
It takes out, cools down when viscous hand.
The benefits of tonifying kidney and benefiting sperm is played altogether by full side, and promoting blood circulation is raw new, then essence and blood foot, born of the same parents can train, and tire is pregnant to be into.
The beneficial effects of the present invention are: the present invention is with above-mentioned bulk pharmaceutical chemicals prescription, invigorating kidney, promoting blood circulation, born of the same parents are trained in replenishing essence, to enhance
The endometrium thickness of women increases menstrual flow, improves the ability for breeding fetus of women, clinical treatment effective percentage is
97.78%.
Specific embodiment
Illustrate its effect below in conjunction with clinical data and typical case.
Embodiment 1
It is formulated (unit: g): Radix Codonopsis 15, Gorgon fruit 15, cornu cerve degelatinatum 15, psoralea corylifolia 15, Herba Cistanches 12, Chinese yam 24, pulp of dogwood fruit
15, Radix Salviae Miltiorrhizae 18, Caulis Spatholobi 18, baked ginger 6, wine spirit rouge 15, radix glycyrrhizae preparata 6.
Preparation and taking methods: water decocts, daily 1 dose, take in the morning and evening in two times.
Illustrate its effect below in conjunction with clinical data and typical case.
1. clinical data
Choosing the first visit time is 01 month 2014 to 01 month 2015, the thin patient of our hospital's Out-patient Clinic of Department of Gynecology endometrium 89,
Patient symptoms include menstrual flow little or no amenorrhea, soreness and weakness of waist and knees light through color, infertile, pale tongue, tongue fur is thin white, deep thready pulse.It is randomly divided into observation group
It is 45, the age 24-48 years old, the course of disease 2 months to 20 years, 5.24 ± 3.33 years average, advanced age 15, there are history of artificial abortion 27,
Intrauterine surgical history 30, genital tuberculosis history 10.It is control group 44, the age 23-49 years old, the course of disease 3 months to 20 years, average
5.54 ± 5.0 years, advanced age 14, there are history of artificial abortion 25, intrauterine surgical history 28, genital tuberculosis history 10.
2. method
2.1 treatment method
Control group: oral Progynova, one time a day, each 1mg even served 6 months.Observation group takes orally Chinese medicine of the present invention, daily
One, a point morning and evening takes twice, takes 6 months.If patient fully recovers in advance during this period, i.e. withdrawal, longest treatment time
It is 6 months.Continue observation 6 months after two groups of drug withdrawals.
2.2. observation index
(1) observing pretherapy and post-treatment menstrual flow improves situation: menstrual flow how much criterion is with reference to the clinical undergraduate course doctor of artificial satellite's version
It learns teaching material the 8th edition " gynecotokology ".
(2) pretherapy and post-treatment endometrium thickness variation is observed；
(3) adverse reaction is recorded.
2.3 statistical method
All data carry out x with SPSS12.0for windows software package2It examines.
3 results
3.1 recoveries from illness: menstrual flow has been restored normally, and endometrium thickness restores normal, other clinical symptoms thoroughly disappear, and
And no reduction is measured after being discontinued.Effective: hyper-menorrhea one third or menstrual flow are greater than 20ml, and endometrium thickness increases
But not up to normal, other clinical symptoms disappear substantially.Effective: menstrual flow increases a little earlier above, and endometrium thickness slightly changes
Kind, other clinical symptoms make moderate progress, and symptom does not aggravate in drug withdrawal 3 months.It is invalid: endometrium thickness without improve or it is thinner,
Cardinal symptom is unchanged or deteriorates, and localized variation has exacerbation trend.
3.2 two groups of Clinical efficacy comparisons
Two groups of patient clinical curative effect comparison results are shown in Table 1.
1 two groups of patient clinical curative effects of table compare [n (%)]
| Group | n | Recovery from illness | It is effective | Effectively | In vain | Total effective rate |
| Observation group | 45 | 12(26.67) | 18(40) | 14(31.11) | 1(2.22) | 97.78% |
| Control group | 44 | 4(9.09) | 16(36.36) | 12(27.27) | 12(27.27) | 72.73% |
P < 0.05 compared with the control group.
3.3 two groups of pretherapy and post-treatment menstrual flows improve situation
Patient's (except amenorrhea patients) treatment results that menstrual flow changes before and after treatment are shown in Table 2.
The pretherapy and post-treatment menstrual flow of 2 two groups of patients of table improves situation (n)
P < 0.05 compared with the control group.
3.4 adverse reaction
There are 13 adverse reactions in control group, and incidence 29.55%, observation group has no adverse reaction.
3.5 follow-ups recurrence
5 are recurred in follow-up 6 months after drug withdrawal, observation group, recurrence rate 11.11%.Control group recurs 23, recurrence rate
52.27%.It can thus be seen that Chinese medicine treatment endometrium of the present invention is thin (total effective rate 97.78%) curative for effect, no secondary work
With recurrence rate after healing is extremely low.
Two, typical case
Typical case 1: Lee, female are 24 years old, unmarried.
First visit on December 20 in 2015.Readme Hypomenorrhea more than 10 years, exacerbation of symptoms, menstrual flow were obvious earlier above in this year
It reduces, 2 days i.e. net.Symptoms include: 2-3/30-35 days 14 years old, Hypomenorrhea, the light matter of color was dilute, no dysmenorrhea, lassitude in loin and legs, dizziness and tinnitus,
Complexion is dark dim, and pale tongue is dim, and tongue fur is thin white, deep thready pulse.LMP:2015 December 1.G0.B ultrasound prompt uterus and double accessory area have no
It is obvious abnormal, interior film thickness 0.5cm.It is diagnosed as hypomenorrhia, card belongs to deficiency of kidney-essence, controls suitable kidney tonifying, essence replenishing.Give reality of the invention
The prescription therapeutic for applying example 1, is decocted in water for oral dose, and one one, and a point morning and evening takes twice.
Two examine: on January 1st, 2016.It states this menstrual flow to increase earlier above, soreness and weakness of waist and knees, the symptoms such as dizziness and tinnitus obviously subtract
Gently.Most immediate cause operating pressure is big, has a sleepless night.Then add Radix Polygalae 6g, arillus longan 10g on the basis of former side.
Three examine: on 2 3rd, 2016.State this menstrual flow increased significantly earlier above, and color is scarlet, matter can, soreness and weakness of waist and knees is dizzy
The symptoms such as tinnitus disappear substantially, and sleep quality is obviously improved, and endometrium thickness restores normal.The prescription of embodiment 1 is with 10 doses
To consolidate curative effect.
So far, hyper-menorrhea, 5-6 days are net for follow-up, chromaticness can, no dysmenorrhea and other are uncomfortable.
Typical case 2: Xu certain, female is 30 years old, married.
First visit on January 5 in 2016.Because peritubal adhesions are in Hospital in Shandong row IVF, postfactor Endometrium is thin to be taken
Disappear the transplanting of this period, previously 2 history of artificial abortion, 1 history of medical abortion.Menstruation rule, 3/28-30 days 14 years old, amount was few, color
It is light, matter can, slight dysmenorrhea, it is cool to fear cold limb, clear abundant urine, pale tongue, whitish tongue, and arteries and veins is thin.LMP:2015 December 20.G3A3.Woman
Section checks: vulva development is normal, and vagina is unobstructed, and uterine neck is smooth, uterus normal in size, no tenderness, double accessory area no abnormality seen.B
Super prompt uterus and double accessory area are shown no obvious abnormalities, interior film thickness 0.6cm.Card belongs to the insufficiency of the kidney yang, controls and preferably tonifies the kidney and support yang, replenishing essence training
Born of the same parents.The prescription therapeutic for giving the embodiment of the present invention 1, is decocted in water for oral dose, and one one, and a point morning and evening takes twice.
Two examine: on 2 5th, 2016.Hyper-menorrhea is stated, the symptoms such as cold, clear abundant urine mitigate, remaining no discomfort.B ultrasound shows
Endometrium 0.8cm.Top is after with 14 doses.
Three examine: on 2 19th, 2016.Menstrual flow increased significantly, and the symptoms such as cold, clear abundant urine disappear, no discomfort.B ultrasound
Show endometrium 1.0cm.Top is after with 14 doses.
Follow-up so far, successful pregnancies after graft.
Typical case 3: Zheng, female are 29 years old, married.
First visit on January 1 in 2016.Get married 1 year or more, unpregnancy is not practised contraception so far, delayed menstrual cycle, 2-3/40-45 days 16 years old,
Amount is few, and color is light, and usually leukorrhea amount is more, and the cold limb of abdomen is cold, and sexual desire is indifferent, and complexion is dark dim, pale tongue, white,slippery and moist fur, deep thready pulse.LMP:2015
On December 31, in.G0.In October, 2015 is shown in the court row HSG: bilateral salpingo is unobstructed.Gynecologial examination: vulva development is normal, yin
Road is unobstructed, and uterine neck is smooth, uterus normal in size, no tenderness, double accessory area no abnormality seen.B ultrasound prompts uterus and double accessory area not
See obvious exception, interior film thickness 0.4cm.It is diagnosed as kidney-yang deficiency infertility, card belongs to the insufficiency of the kidney yang, controls and preferably tonify the kidney and support yang, and born of the same parents are trained in replenishing essence.
The prescription therapeutic for giving the embodiment of the present invention 1, is decocted in water for oral dose, and one one, and a point morning and evening takes twice.Non- menstrual period medication.
Two examine: on January 15th, 2016.Leukorrhea to be stated to reduce earlier above, cold symptom is substantially reduced, and the same branch of a family quality is improved,
Pale tongue, whitish tongue, arteries and veins are thin.B ultrasound shows inner membrance 0.7cm.Top is after with 20 doses, B ultrasound dynamic monitoring endometrium thickness and ovarian follicular growth
Developmental state and guides the same branch of a family.
Three examine: on 2 4th, 2016.State menstrual flow increased significantly earlier above, and color is scarlet, and the cold limb of abdomen is cold, the symptoms such as sexual desire is indifferent
It disappears, no discomfort.Top after with 20 doses to consolidate curative effect, B ultrasound dynamic monitoring endometrium thickness and Follicular growth situation,
And guide the same branch of a family.
The four methods of diagnosis: on April 1st, 2016.HCG ﹙+﹚ is urinated from surveying, has a blood test and shows: E2:325P:35 β-HCG:6000.B ultrasound shows: uterine cavity
Interior spy and 1.20 × 0.80 × 0.70cm of gestation sac.It visits and yolk bag, does not visit and tire bud.Ultrasound diagnosis: early pregnancy (it is pregnant to meet 5+
Week).
So far, embryonic development is normal for follow-up.
Embodiment 2
It is formulated (unit: g): Radix Codonopsis 18, Gorgon fruit 18, cornu cerve degelatinatum 18, psoralea corylifolia 18, Herba Cistanches 12, Chinese yam 25, pulp of dogwood fruit
18, Radix Salviae Miltiorrhizae 20, Caulis Spatholobi 20, baked ginger 8, wine spirit rouge 18, radix glycyrrhizae preparata 8.
Preparation and taking methods: water decocts, daily 1 dose, take in the morning and evening in two times.
Embodiment 3
It is formulated (unit: g): Radix Codonopsis 12, Gorgon fruit 12, cornu cerve degelatinatum 12, psoralea corylifolia 12, Herba Cistanches 10, Chinese yam 22, pulp of dogwood fruit
12, Radix Salviae Miltiorrhizae 15, Caulis Spatholobi 15, baked ginger 5, wine spirit rouge 12, radix glycyrrhizae preparata.
Preparation and taking methods: water decocts, daily 1 dose, take in the morning and evening in two times.
Embodiment 4
It is formulated (parts by weight): Radix Codonopsis 15, Gorgon fruit 15, cornu cerve degelatinatum 15, psoralea corylifolia 15, Herba Cistanches 12, Chinese yam 24, pulp of dogwood fruit
15, Radix Salviae Miltiorrhizae 18, Caulis Spatholobi 18, baked ginger 6, wine spirit rouge 15, radix glycyrrhizae preparata 6.
Preparation method:
(1) 70% ethyl alcohol heating and refluxing extraction 2 is added in Radix Codonopsis, psoralea corylifolia, Herba Cistanches, pulp of dogwood fruit, Radix Salviae Miltiorrhizae and wine spirit rouge
It is secondary, 40 minutes every time；Combined extract, after 200 mesh net filtrations, heating removes ethyl alcohol, obtains extracting solution；
(2) then by remaining 6 taste Chinese medicine (Gorgon fruit, cornu cerve degelatinatum, Chinese yam, Caulis Spatholobi, baked ginger and radix glycyrrhizae preparata) and step (1)
The dregs of a decoction merge, add water to cook 2 times, every time decoct 40 minutes；Merge decoction liquor to be decocted after 200 mesh net filtrations
Liquid；
(3) merge the extracting solution of step (1) and the decoction liquor of step (2), the heated relative density that is concentrated into is 1.25 (60
DEG C) thick paste, the cane sugar powder that 2 times of quality are then added is uniformly mixed, a small amount of 70% ethyl alcohol is then added and is made softwood, crosses 14 mesh
Nylon mesh granulation；After wet granular is dry, re-sieving retains the particle of 14-50 mesh, is then distributed into every bag of 10g.
Instructions of taking: warm water is taken after mixing it with water, and 3 times a day, once a bag, is taken within 30~60 minutes after meal.
Claims (7)
1. a kind of treat the thin Chinese medicine of endometrium, characterized in that be mainly made of the bulk pharmaceutical chemicals of following weight parts: Radix Codonopsis 10~
20 parts, 10~20 parts of Gorgon fruit, 10~20 parts of cornu cerve degelatinatum, 10~20 parts of psoralea corylifolia, 10~20 parts of Herba Cistanches, 20~30 parts of Chinese yam,
10~20 parts of pulp of dogwood fruit, 10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of Caulis Spatholobi, 5~10 parts of baked ginger, 10~20 parts of wine spirit rouge, radix glycyrrhizae preparata 5
~10 parts.
2. a kind of as described in claim 1 treat the thin Chinese medicine of endometrium, characterized in that mainly by the original of following weight parts
Material medicine is made: 15 parts of Radix Codonopsis, 15 parts of Gorgon fruit, and 15 parts of cornu cerve degelatinatum, 15 parts of psoralea corylifolia, 12 parts of Herba Cistanches, 24 parts of Chinese yam, pulp of dogwood fruit 15
Part, 18 parts of Radix Salviae Miltiorrhizae, 18 parts of Caulis Spatholobi, 6 parts of baked ginger, 15 parts of wine spirit rouge, 6 parts of radix glycyrrhizae preparata.
3. a kind of as claimed in claim 2 treat the thin Chinese medicine of endometrium, characterized in that by the bulk pharmaceutical chemicals of following weight parts
It is made: 15 parts of Radix Codonopsis, 15 parts of Gorgon fruit, 15 parts of cornu cerve degelatinatum, 15 parts of psoralea corylifolia, 12 parts of Herba Cistanches, 24 parts of Chinese yam, 15 parts of pulp of dogwood fruit,
18 parts of Radix Salviae Miltiorrhizae, 18 parts of Caulis Spatholobi, 6 parts of baked ginger, 15 parts of wine spirit rouge, 6 parts of radix glycyrrhizae preparata.
4. a kind of as claimed in claim 2 treat the thin Chinese medicine of endometrium, characterized in that by the bulk pharmaceutical chemicals of following weight parts
It is made: 15 parts of Radix Codonopsis, 15 parts of Gorgon fruit, 15 parts of cornu cerve degelatinatum, 15 parts of psoralea corylifolia, 12 parts of Herba Cistanches, 24 parts of Chinese yam, 15 parts of pulp of dogwood fruit,
18 parts of Radix Salviae Miltiorrhizae, 18 parts of Caulis Spatholobi, 6 parts of baked ginger, 15 parts of wine spirit rouge, 6 parts of radix glycyrrhizae preparata, 6 parts of Radix Polygalae, 10 parts of arillus longan.
5. a kind of as described in any one of claim 1-4 treats the thin Chinese medicine of endometrium, characterized in that the Chinese medicine
For granule, pill, capsule, tablet, oral solution.
6. a kind of as claimed in claim 5 treat the thin Chinese medicine of endometrium, characterized in that the Chinese medicine is granule.
7. a kind of preparation method for treating the thin Chinese medicine of endometrium as claimed in claim 6, characterized in that
(1) by Radix Codonopsis, psoralea corylifolia, Herba Cistanches, pulp of dogwood fruit, Radix Salviae Miltiorrhizae and wine spirit rouge addition 70% ethyl alcohol heating and refluxing extraction 2 times, often
Secondary 0.5~1 hour；Combined extract, after 200 mesh net filtrations, heating removes ethyl alcohol, obtains extracting solution；
(2) then remaining 6 taste Chinese medicine and the dregs of a decoction of step (1) are merged, adds water to cook 2 times, it is small decocts 0.5~1.5 every time
When；Merge decoction liquor and obtains decoction liquor after 200 mesh net filtrations；
(3) merge the extracting solution of step (1) and the decoction liquor of step (2), heated relative density when being concentrated into 60 DEG C is 1.20
~1.30 thick paste, the cane sugar powder that 1~3 times of quality is then added are uniformly mixed, are most distributed into after granulation, drying, screening afterwards
Bag.
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| CN107334900A (en) * | 2017-06-09 | 2017-11-10 | 王孟 | It is a kind of to treat thin infertile and amenorrhoea medicament of cause of endometrium and preparation method thereof |
| RU2655538C1 (en) * | 2017-07-17 | 2018-05-28 | федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) | Method of endometrial dysfunction treatment |
| CN112426502B (en) * | 2020-12-11 | 2022-05-03 | 山东宏济堂制药集团股份有限公司 | Application of young chicken essence in preparation of thin endometrium treatment drug |
| CN113018367B (en) * | 2021-03-16 | 2022-03-25 | 南京中医药大学 | Traditional Chinese medicine composition for treating thin endometrial hypomenorrhea and preparation method and application thereof |
| CN117860842B (en) * | 2024-03-13 | 2024-05-28 | 云南省中医医院(云南中医药大学第一附属医院) | Acupoint patch for endometrial repair and application thereof |
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| CN104147559A (en) * | 2014-07-10 | 2014-11-19 | 戴恩成 | Traditional Chinese medicine preparation for treating gynecological endometritis |
| CN105169286A (en) * | 2015-10-26 | 2015-12-23 | 吴淑芬 | Traditional Chinese medicine for treating thin endometrium |
| CN105327067A (en) * | 2015-12-08 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Chinese herbal preparation for treating abortion postoperation internal secretion normal type hypomenorrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104147559A (en) * | 2014-07-10 | 2014-11-19 | 戴恩成 | Traditional Chinese medicine preparation for treating gynecological endometritis |
| CN105169286A (en) * | 2015-10-26 | 2015-12-23 | 吴淑芬 | Traditional Chinese medicine for treating thin endometrium |
| CN105327067A (en) * | 2015-12-08 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Chinese herbal preparation for treating abortion postoperation internal secretion normal type hypomenorrhea |
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