CN104587127B - A kind of Chinese medicine preparation for the treatment of dysfunctional uterine bleeding and preparation method thereof - Google Patents
A kind of Chinese medicine preparation for the treatment of dysfunctional uterine bleeding and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of dysfunctional uterine bleeding and preparation method thereof.Described Chinese medicine preparation is made up of following raw material: Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Radix Rubiae, Rhizoma Cimicifugae, Radix Angelicae Sinensis, stir-fry Rhizoma Cyperi, Herba Ecliptae, Radix Notoginseng, Fructus Ligustri Lucidi.Chinese medicine preparation of the present invention for primary efficacy, has good therapeutic effect to through symptoms such as amount, menstrual period, cycle and hemostasis in the recent period with nourishing the liver and kidney, invigorating QI to consolidate the body surface resistance, nourishing blood for regulating menstruation.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of dysfunctional uterine bleeding and preparation method thereof.
Background technology
Dysfunctional uterine bleeding (dysfunctionaluterinebleeding, DUB is called for short anovulatory dysfunctional uterine hemorrhage) refer to caused by non-systemic or reproductive system various organic diseases locally, owing to regulating the abnormal uterine bleeding that the Factors Affecting Neuroendocrine Mechanisms of reproduction is not normal caused.There is ovulatory and anovulatory anovulatory dysfunctional uterine hemorrhage two class clinical being divided into, and wherein anovulatory anovulatory dysfunctional uterine hemorrhage accounts for more than 80%.
Without this name of disease in Chinese medicine, belong to " metrorrhagia " category according to its clinical manifestation.Metrorrhagia be because of heat in blood, insufficiency of the spleen, suffer from a deficiency of the kidney, blood stasis etc. causes the impairment of chong and ren channels, can not keep within bounds menses, under time non-.Amount is many if note person is for collapsing, and the few dripping person not to the utmost of amount is for leaking, and both often alternately occur.
Modern medicine is to the treatment of primary disease still with gonadotherapy, and anti-fibrinolytic treatment and operative treatment are common method.As the gonadotherapy of main therapy, curative effect is difficult to consolidate, and side effect is large.The traditional Chinese medical science have accumulated rich experience to the treatment of dysfunctional uterine bleeding and anti-recurrence, has the advantages that curative effect is high, side effect is little, relapse rate is low, is worth studying and applying further.
Summary of the invention
The invention provides a kind of new Chinese medicine preparation for the treatment of dysfunctional uterine bleeding, this Chinese medicine preparation is rapid-action, good effect, toxic and side effects is little, and it is obtained by following raw material: Radix Codonopsis, the Radix Astragali, the Radix Paeoniae Alba, Radix Rubiae, Rhizoma Cimicifugae, Radix Angelicae Sinensis, stir-fry Rhizoma Cyperi, Herba Ecliptae, Radix Notoginseng, Fructus Ligustri Lucidi.
The technical scheme adopted for solving its technical problem is the Chinese medicine preparation of described treatment dysfunctional uterine bleeding, be made up of the medicine material of following weight: Radix Codonopsis 8-16 part, Radix Astragali 10-15 part, Radix Paeoniae Alba 5-15 part, Radix Rubiae 6-12 part, Rhizoma Cimicifugae 10-20 part, Radix Angelicae Sinensis 10-20 part, fries Rhizoma Cyperi 15-25 part, Herba Ecliptae 8-16 part, Radix Notoginseng 8-12 part, Fructus Ligustri Lucidi 8-12 part.
The preferred technical solution of the present invention is, described Chinese medicine preparation of the present invention is obtained by the raw material of following weight portion: Radix Codonopsis 12 parts, the Radix Astragali 12 parts, the Radix Paeoniae Alba 10 parts, 9 parts, Radix Rubiae, Rhizoma Cimicifugae 15 parts, Radix Angelicae Sinensis 15 parts, fries Rhizoma Cyperi 20 parts, Herba Ecliptae 12 parts, Radix Notoginseng 10 parts, Fructus Ligustri Lucidi 10 parts.
Present invention also offers the preparation method of described Chinese medicine preparation, after specifically comprising the steps: the raw material Radix Codonopsis of above-mentioned weight portion, the Radix Astragali, the Radix Paeoniae Alba, Radix Rubiae, Rhizoma Cimicifugae, Radix Angelicae Sinensis, stir-fry Rhizoma Cyperi, Herba Ecliptae, Radix Notoginseng, Fructus Ligustri Lucidi to pulverize respectively, add the soak by water 2 times of medical material gross mass 10 times amount, each 2.5 hours, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 75 DEG C, its relative density is the thick paste of 1.10-1.15, to obtain final product.
Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to use or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.As the oral drugs of the solid dosage form such as conventional tablet, capsule, granule, pill, powder can be made, the oral drugs of the liquid forms such as syrup, oral liquid, water preparation, mixture, decoction also can be made.Therefore, in this Chinese medicine preparation except effective ingredient, pharmaceutically acceptable adjuvant can also be contained.Preferably, Chinese medicine preparation of the present invention conveniently preparation technology be prepared into oral liquid, electuary, granule, tablet, capsule or powder etc.
The present invention also asks to protect above-mentioned Chinese medicine preparation in the purposes of preparation treatment dysfunctional uterine bleeding particularly in preparation treatment YIN-deficiency type dysfunctional uterine bleeding medicine.Known by clinical trial, after follow-up observation 3 menstrual cycle, Outcome measure is known, and treatment group and matched group symptom curative effect total effective rate are respectively 92%, 88%, and hemostasis in the recent period judges that curative effect total effective rate is 96%.Treatment group total effective rate and in the recent period hemostasis judge that curative effect total effective rate is higher than matched group, and this Chinese medicine preparation not only improves obviously through symptoms such as amount, menstrual period, cycles as seen, and hemostasis judges curative effect also comparatively satisfaction in the recent period.In safety evaluatio, before and after treatment group patient consumes, do not find obvious exception.Illustrate that using Chinese medicine preparation of the present invention treatment dysfunctional uterine bleeding particularly to treat belongs to yin deficiency syndrome dysfunctional uterine bleeding determined curative effect thus, serve the remarkable result for the treatment of both the principal and secondary aspects of a disease, safe and reliable, can be used as the effective ways for the treatment of yin deficiency syndrome dysfunctional uterine bleeding disease, be worth of widely use in clinical.
In Chinese medicine preparation of the present invention, described Radix Codonopsis, sweet, flat.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.。
The Radix Astragali, sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
The Radix Paeoniae Alba, bitter, sour, be slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Rubiae, bitter, cold.Return Liver Channel.Removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.
Rhizoma Cimicifugae, pungent, micro-sweet, be slightly cold.Return lung, spleen, stomach, large intestine channel.Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, uterine prolapse.
Radix Angelicae Sinensis, sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver; The heart; Spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down
Fry Rhizoma Cyperi, pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Herba Ecliptae is also known as Herba Ecliptae, sweet, sour, cold.Return kidney, Liver Channel.Nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Radix Notoginseng, sweet, micro-hardship, temperature.Return liver, stomach warp.Dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
Fructus Ligustri Lucidi, sweet, bitter, cold.Return liver, kidney channel.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
The present invention is from the cogitive theory of the traditional Chinese medical science to the deficiency of YIN, scientific composition is carried out for the purpose of nourishing the liver and kidney, invigorating QI to consolidate the body surface resistance, nourishing blood for regulating menstruation, Chinese medicine preparation mild in medicine property of the present invention and, safe and reliable, prepare easy, cost is low, and curative effect is fast, effectively can treat dysfunctional uterine bleeding particularly YIN-deficiency type dysfunctional uterine bleeding.Through clinical practice checking, take Chinese medicine preparation untoward reaction of the present invention and side effect low, safety coefficient is high, determined curative effect, and clinical observation total effective rate is high, and dosage form medication prepared by simultaneously the present invention is convenient, improves the compliance of patient.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Take each raw material of the present invention by following weight portion: Radix Codonopsis 12 parts, the Radix Astragali 12 parts, the Radix Paeoniae Alba 10 parts, 9 parts, Radix Rubiae, Rhizoma Cimicifugae 15 parts, Radix Angelicae Sinensis 15 parts, fry Rhizoma Cyperi 20 parts, Herba Ecliptae 12 parts, Radix Notoginseng 10 parts, Fructus Ligustri Lucidi 10 parts.
Preparation technology is as follows: after the raw material Radix Codonopsis of above-mentioned weight portion, the Radix Astragali, the Radix Paeoniae Alba, Radix Rubiae, Rhizoma Cimicifugae, Radix Angelicae Sinensis, stir-fry Rhizoma Cyperi, Herba Ecliptae, Radix Notoginseng, Fructus Ligustri Lucidi being pulverized respectively, add the soak by water 2 times of gross mass 10 times amount, each 2.5 hours, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 75 DEG C, its relative density is the thick paste of 1.10-1.15, to obtain final product.Those skilled in the art directly can be used as medicine on this basis and be used or add adjuvant conventional formulation technique and obtain the conventional oral formulations such as oral liquid, granule, electuary, capsule or powder.
When using Chinese medicine preparation of the present invention to treat dysfunctional uterine bleeding card, when taking prepared granule or electuary, every bag contains crude drug amount 3g, every day 2 times, each 2 bags.
Embodiment 2
Take each raw material of the present invention by following weight portion: Radix Codonopsis 8 parts, the Radix Astragali 10 parts, the Radix Paeoniae Alba 5 parts, 6 parts, Radix Rubiae, Rhizoma Cimicifugae 10 parts, Radix Angelicae Sinensis 10 parts, fry Rhizoma Cyperi 15 parts, Herba Ecliptae 8 parts, Radix Notoginseng 8 parts, Fructus Ligustri Lucidi 8 parts.
Embodiment 3
Take each raw material of the present invention by following weight portion: Radix Codonopsis 16 parts, the Radix Astragali 15 parts, the Radix Paeoniae Alba 15 parts, 12 parts, Radix Rubiae, Rhizoma Cimicifugae 20 parts, Radix Angelicae Sinensis 20 parts, fry Rhizoma Cyperi 25 parts, Herba Ecliptae 16 parts, Radix Notoginseng 12 parts, Fructus Ligustri Lucidi 12 parts.
Embodiment 4
Take each raw material of the present invention by following weight portion: Radix Codonopsis 8 parts, the Radix Astragali 10 parts, the Radix Paeoniae Alba 15 parts, 12 parts, Radix Rubiae, Rhizoma Cimicifugae 10 parts, Radix Angelicae Sinensis 10 parts, fry Rhizoma Cyperi 25 parts, Herba Ecliptae 16 parts, Radix Notoginseng 8 parts, Fructus Ligustri Lucidi 8 parts.
Embodiment 5
Take each raw material of the present invention by following weight portion: Radix Codonopsis 16 parts, the Radix Astragali 15 parts, the Radix Paeoniae Alba 5 parts, 6 parts, Radix Rubiae, Rhizoma Cimicifugae 20 parts, Radix Angelicae Sinensis 20 parts, fry Rhizoma Cyperi 15 parts, Herba Ecliptae 8 parts, Radix Notoginseng 12 parts, Fructus Ligustri Lucidi 12 parts.
The preparation technology of embodiment 2-5 is with embodiment 1.
The clinical observation of embodiment 6 Chinese medicine preparation treatment of the present invention dysfunctional uterine bleeding
1, case-data: patient 50 example outpatient service and ward made a definite diagnosis, is divided into treatment group, matched group at random.Wherein treatment group 25 example, the oldest person 29 years old, reckling 18 years old, course of disease 4-24 month.Matched group 25 example, the oldest person 28 years old, reckling 18 years old, course of disease 4-24 month.Two groups of patients there was no significant difference in age, the course of disease, has comparability.
2, diagnosis basis:
(1) metrorrhagia diagnostic criteria:
1) menses no periodic can follow.
2) through amount or sudden and violent lower to note, or persistent vaginal bloody discharge, or both alternately occur.
3) vaginal hemorrhage that must cause with vaginal bleeding during pregnancy, ectopic pregnancy, postpartum hemorrhage, leucorrhea with bloody discharge and lump in the abdomen, wound is differentiated mutually.
(2) YIN-deficiency type diagnosis basis:
Suddenly hemorrhage, amount is many, or not to the utmost dripping, and color is scarlet, matter thickness; Have a dizzy spell; Tinnitus cardiopalmus; Dysphoria with feverish sensation in the chest palms and soles; Insomnia, night sweat; Soreness of the waist and knees; Red tongue or partially red, thin fur; Thready and rapid pulse.
3, inclusive criteria:
(1) diagnosis basis is met;
(2) YIN-deficiency type metrorrhagia diagnostic criteria person is met;
(3) age 18-30 year;
(4) clinical research " Informed Consent Form " is signed.
4, Excluded cases standard:
(1) age under-18s, more than 30 years old person;
(2) hemorrhage caused by the diseases such as ectopic pregnancy, pregnancy complications, intrauterine device, wound, reproductive tract infection, tumor, or systemic disease, as causers such as hepatopathy, hematopathy, thyroid, adrenal gland, disease of pituitary gland;
(3) be associated with the critical primary diseases such as liver, kidney, cardiovascular and hemopoietic system, merge other severe primary diseases, psychotic;
(4) other clinical trial persons were participated in nearly one month.
5, to reject and the standard that comes off:
(1), after case is selected in, find not meet inclusive criteria or meet exclusion standard person;
(2) there is serious adverse events, judge to stop this case clinical trial person according to doctor;
(3) case selected after data not entirely or not by specifying medication person;
(4) in process of the test, experimenter's compliance is poor, and affect the treatment estimator.
6, usage and dosage:
Treatment group: give Drug therapy of the present invention, granule prepared by Example 1, every bag containing crude drug amount 3g, every day 2 times, each 2 bags, early, before dinner half an hour respectively take 2 bags.
Matched group: oral Marvelon (Nanjing Ou Jianong pharmaceutical Co. Ltd), every day 3 times, 1 piece/times.Colporrhagia reduces latter 3 days decrements 1 time, and 1 decrement 1, to amount every day 1 time 1, is maintained until and stops blooding latter 21 days.Within 5th day, start next cycle therapy in menstruation after drug withdrawal, every day 1, serve on drug withdrawal in 21 days.
Each group is treated 3 months all continuously above, and judges curative effect after follow-up observation 3 menstrual cycle.
7, criterion of therapeutical effect:
(1) cure: recover normal through amount, menstrual period, cycle, more than 3 menstrual cycle can be maintained.
(2) take a turn for the better: though recover normal through amount, menstrual period, cycle, 3 menstrual cycle can not be maintained.Or reduce through amount, or menstrual period shorten.
(3) do not heal: vaginal hemorrhage is unchanged.
8, hemostatic healing efficacy criterion in the recent period:
With reference to the criterion of " combination of Chinese and Western medicine diagnosis and treatment standard of national dysfunctional uterine bleeding " hemostatic healing efficacy near-mid term, stop required natural law evaluation according to colporrhagia after taking medicine.
(1) quick-acting: vaginal hemorrhage stops within 3 days after medication.
(2) effective: vaginal hemorrhage stops within 7 days after medication.
(3) effective: vaginal hemorrhage stops within 10 days after medication.
(4) invalid: vaginal hemorrhage stops for 10 days after medication not yet.
9, therapeutic outcome: after follow-up observation 3 menstrual cycle, Outcome measure is known, treatment group and matched group symptom curative effect total effective rate are respectively 92%, 88%.Recent hemostasis judges that curative effect total effective rate is 96%, in table 1, table 2.
Table 1. liang group symptom comparitive study
| Group | Cure | Take a turn for the better | Do not heal | Total effective rate % |
| Treatment group | 8(32％) | 15 | 2 | 23(92％) |
| Matched group | 6(24％) | 16 | 3 | 22(88％) |
Treatment group symptom total effective rate is obviously better than matched group as can be seen from Table 1.
The table 2. liang recent hemostatic healing efficacy of group compares
| Group | Quick-acting | Effective | Effectively | Invalid | Total effective rate % |
| Treatment group | 6(24％) | 10 | 8 | 1 | 24(96％) |
| Matched group | 7(28％) | 9 | 8 | 1 | 24(96％) |
Treatment group is stopped blooding in the recent period and is judged that curative effect is close with matched group as can be seen from Table 2.
From clinical observation result, treatment group symptom total effective rate and in the recent period hemostasis judge that curative effect is higher than matched group, and this Chinese medicine preparation not only improves obviously through symptoms such as amount, menstrual period, cycles as seen, and hemostasis judges curative effect also comparatively satisfaction in the recent period.In safety evaluatio, before and after treatment group patient consumes, do not find obvious exception.Illustrate that using Chinese medicine preparation of the present invention treatment dysfunctional uterine bleeding particularly to treat belongs to YIN-deficiency type dysfunctional uterine bleeding determined curative effect thus, safe and reliable, can be used as the effective ways for the treatment of yin deficiency syndrome dysfunctional uterine bleeding, be worth of widely use in clinical.
Claims (8)
1. treat the Chinese medicine preparation of dysfunctional uterine bleeding for one kind, it is characterized in that, it is obtained by the raw material of following weight portion: Radix Codonopsis 8-16 part, Radix Astragali 10-15 part, Radix Paeoniae Alba 5-15 part, Radix Rubiae 6-12 part, Rhizoma Cimicifugae 10-20 part, Radix Angelicae Sinensis 10-20 part, fry Rhizoma Cyperi 15-25 part, Herba Ecliptae 8-16 part, Radix Notoginseng 8-12 part, Fructus Ligustri Lucidi 8-12 part.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, it is obtained by the raw material of following weight portion: Radix Codonopsis 12 parts, the Radix Astragali 12 parts, the Radix Paeoniae Alba 10 parts, 9 parts, Radix Rubiae, Rhizoma Cimicifugae 15 parts, Radix Angelicae Sinensis 15 parts, fry Rhizoma Cyperi 20 parts, Herba Ecliptae 12 parts, Radix Notoginseng 10 parts, Fructus Ligustri Lucidi 10 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, described Chinese medicine preparation is oral formulations.
4. Chinese medicine preparation as claimed in claim 3, it is characterized in that, described oral formulations is oral liquid, granule, electuary, capsule or powder.
5. Chinese medicine preparation as claimed in claim 4, it is characterized in that, described oral formulations is granule.
6. prepare the method for Chinese medicine preparation as claimed in claim 1 or 2 for one kind, it is characterized in that, after comprising the steps: the raw material Radix Codonopsis of above-mentioned weight portion, the Radix Astragali, the Radix Paeoniae Alba, Radix Rubiae, Rhizoma Cimicifugae, Radix Angelicae Sinensis, stir-fry Rhizoma Cyperi, Herba Ecliptae, Radix Notoginseng, Fructus Ligustri Lucidi to pulverize respectively, add the soak by water 2 times of medical material gross mass 10 times amount, each 2.5 hours, filter cleaner extracting juice merged, and when the filtrate after merging is concentrated into 75 DEG C, its relative density is the thick paste of 1.10-1.15, to obtain final product.
7. the purposes of Chinese medicine preparation as claimed in claim 1 or 2 in preparation treatment dysfunctional uterine bleeding medicine.
8. the purposes of Chinese medicine preparation as claimed in claim 1 or 2 in preparation treatment YIN-deficiency type dysfunctional uterine bleeding medicine.
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| CN116850225A (en) * | 2023-08-06 | 2023-10-10 | 长春中医药大学 | Traditional Chinese medicine preparation for treating gynecological abnormal uterine bleeding and preparation method thereof |
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| 中医药治疗功能性子宫出血的研究进展;鹿鸣瑞等;《中国民间疗法》;20051031;第13卷(第10期);62-64 * |
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