CN104173981A - Medical decoction for treating uterine fibroids and hypertrophy of uterus and preparation method thereof - Google Patents

Medical decoction for treating uterine fibroids and hypertrophy of uterus and preparation method thereof Download PDF

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CN104173981A
CN104173981A CN201410423660.0A CN201410423660A CN104173981A CN 104173981 A CN104173981 A CN 104173981A CN 201410423660 A CN201410423660 A CN 201410423660A CN 104173981 A CN104173981 A CN 104173981A
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parts
weight
medicine
uterus
hypertrophy
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夏瑜
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Sichuan Jintang Haina Biomedical Technology Institute
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Sichuan Jintang Haina Biomedical Technology Institute
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Abstract

The invention relates to medical decoction for treating uterine fibroids and hypertrophy of uterus and a preparation method thereof. The medical decoction for treating the uterine fibroids and hypertrophy of uterus is prepared from 1-4 parts by weight of Chinese angelica, 1-4 parts by weight of root of three-nerved spicebush, 1-4 parts by weight of szechuan lovage rhizome, 1-4 parts by weight of honey-fried liquorice, 1-4 parts by weight of baked ginger, 1-4 parts by weight of peach kernel, 1-4 parts by weight of schizonepeta spike and 1-4 parts by weight of motherwort respectively. The preparation method of the medical decoction comprises the following steps: selecting 1-4 parts by weight of high-quality Chinese angelica, 1-4 parts by weight of high-quality root of three-nerved spicebush, 1-4 parts by weight of high-quality szechuan lovage rhizome, 1-4 parts by weight of high-quality honey-fried liquorice, 1-4 parts by weight of high-quality baked ginger, 1-4 parts by weight of high-quality peach kernel, 1-4 parts by weight of high-quality schizonepeta spike and 1-4 parts by weight of high-quality motherwort respectively, respectively smashing the selected Chinese angelica, root of three-nerved spicebush, szechuan lovage rhizome, honey-fried liquorice, baked ginger, peach kernel, schizonepeta spike and motherwort into granules (with the granularity of 5-6mm) for later use; packaging the smashed medicine granules into cloth bags and tying, firstly soaking in cold boiled water for 40-50 minutes until medicine tissues are soaked, then putting the cloth bags into a medicine decocting machine, injecting an appropriate amount of cold boiled water, decocting and boiling with a strong fire, then decocting with a slow fire for 55 minutes, after medicines are decocted, concentrating to obtain 1800ml of 50% traditional Chinese medicine liquor, bagging and sealing.

Description

A kind of decoction medicine and preparation method for the treatment of hysteromyoma and hypertrophy of uterus
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of decoction medicine for the treatment of hysteromyoma and hypertrophy of uterus, particularly for human uterus's muscular tumor and hypertrophy of uterus patient's decoction medicine and the field of preparation method.
Background technology
The clinical manifestation of hysteromyoma and hypertrophy of uterus has similarity, if hysteromyoma is between single flesh wall or mucosa lower time, its palace body also shows as even increase, now be difficult for differentiating with hypertrophy of uterus, but hysteromyoma and hypertrophy of uterus are two kinds of different diseases after all, respectively have its own corresponding characteristicness, the main distinction is as follows: A, morbidity crowd, hysteromyoma is the modal benign tumors of female sex organs, is common in the women of 30~50 years old, and within 20 years old, following person is comparatively rare; Hypertrophy of uterus is more common in puerpera, and sick time is long, and the many persons of the amount of bleeding are anemia looks.B, clinical manifestation, hysteromyoma: how asymptomatic patient is, small number of patients can show as vaginal hemorrhage, abdominal mass and pressure symptom, muscular tumor not of uniform size, differ greatly, large person can reach tens of kilograms, the little situation that even can occur that tens or several hundred muscular tumors are grown simultaneously; Hypertrophy of uterus: typical clinical manifestation is leucorrhoea grow in quantity, the lighter can be without General Symptoms, when inflammation is diffused into pelvic cavity along jarjavay's ligaments, can there is waist and sacrum pain, the symptoms such as the sense of hypogastric region falling inflation and dysmenorrhea increase the weight of when defecation, sexual intercourse, compare with hysteromyoma, during hypertrophy of uterus, uterus is evenly to increase, seldom period of greater than two months gravid uterus.
So, just how finding a kind of Chinese herbal medicine that can effectively thoroughly treat above-mentioned hysteromyoma and hypertrophy of uterus, and can effectively guarantee can not recur after curing recovery, is the practical problem that we will solve at present.
Summary of the invention
The object of this invention is to provide a kind of decoction medicine and preparation method for the treatment of hysteromyoma and hypertrophy of uterus, to solve hysteromyoma and hypertrophy of uterus patient restorative problem early.This medicine is to take common Chinese herbal medicine as raw material, there is advantages of perfect compatibility, make a general survey of full side, the efficacy of a drug is powerful, the pathogenesis that hits, and has fully demonstrated blood circulation promoting and blood stasis dispelling, nourishing blood and invigorating qi, hard masses softening and resolving, promoting the flow of QI in the collateral by warming the meridian, promoting blood flow to regulate menstruation, blood-enriching and blood-promoting circulation, pleasant pain relieving, has drawn blood and return through, the Therapeutic Principle that concocts all medicines.
For reaching the object of foregoing invention, the technical solution adopted in the present invention is: a kind of decoction medicine for the treatment of hysteromyoma and hypertrophy of uterus is provided, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Radix Angelicae Sinensis 1-4 part;
Radix Linderae 1-4 part;
Rhizoma Chuanxiong 1-4 part;
Radix Glycyrrhizae Preparata 1-4 part;
Rhizoma Zingiberis Preparatum 1-4 part;
Semen Persicae 1-4 part;
Herba Schizonepetae 1-4 part;
Herba Leonuri 1-4 part.
Decoction medicine according to treatment hysteromyoma provided by the present invention and hypertrophy of uterus, is characterized in that, each component of described medicine and mass parts thereof are than as follows:
2 parts of Radix Angelicae Sinensis;
2 parts of the Radixs Linderae;
2 parts of Rhizoma Chuanxiongs;
2 parts of Radix Glycyrrhizae Preparatas;
2 parts of Rhizoma Zingiberis Preparatums;
2 parts, Semen Persicae;
2 parts of Herba Schizonepetaes;
2 parts of Herba Leonuris.
Decoction medicine and the preparation method of above-mentioned treatment hysteromyoma and hypertrophy of uterus, is characterized in that, described method comprises the steps:
A, select 2 parts of high-quality clean 2 parts of 2 parts, 2 parts of 2 parts of 2 parts of 2 parts of 2 parts of Radix Angelicae Sinensis, the Radixs Linderae, Rhizoma Chuanxiongs, Radix Glycyrrhizae Preparatas, Rhizoma Zingiberis Preparatums, Semen Persicae, Herba Schizonepetaes and Herba Leonuris, be ground into respectively graininess (granularity is 5mm-6mm) standby;
B, pack the granular medicament crushing in cloth bag tying, prior to soaking 40-50 minute in cold boiled water, to soak into medicine degree of being organized as, then put in boiling machine, inject appropriate cold boiled water, with high heat after fried boiling, change slow fire fried 55 minutes, until medicine fried good after, be condensed into 1800 milliliters of 50% herb liquids, pack sealing.
Decoction medicine and the preparation method of above-mentioned treatment hysteromyoma and hypertrophy of uterus, is characterized in that, described instructions of taking is: by fried good herb liquid potion every day, the morning, noon and afternoon service once, 200 milliliters/time of dosages, taking medicine after meal.
The medicine for the treatment of hysteromyoma provided by the present invention and hypertrophy of uterus is oral traditional Chinese medicine composition, and it take common Chinese herbal medicine as raw material, gives full play to the property of medicine of each component:
Radix Angelicae Sinensis, nature and flavor: sweet in the mouth, pungent, micro-hardship, warm in nature, the effect that has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, is used for the treatment of blood deficiency, shallow complexion, dizzy cardiopalmus, blood deficiency or has the stagnant menoxenia of the stasis of blood, amenorrhea, dysmenorrhea, empty abdominal pain due to cold, angina pectoris, rheumatic arthralgia, traumatic injury etc. concurrently and bitterly demonstrate,prove;
The Radix Linderae, nature and flavor: pungent, warm, there is the effect of pleasant pain relieving, warming kidney for dispelling cold, be used for the treatment of chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea;
Rhizoma Chuanxiong, nature and flavor: acrid in the mouth, warm in nature, the effect with blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping, is used for the treatment of that menoxenia, amenorrhea dysmenorrhea, the stagnant raw meat pain of the stasis of blood in puerperal, lump in the abdomen lump, pain in chest and hypochondrium, headache are dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores;
Radix Glycyrrhizae Preparata, nature and flavor: sweet, flat, there is the effect of spleen reinforcing stomach function regulating, Yiqi and vein recovery, be used for the treatment of weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse;
Rhizoma Zingiberis Preparatum, nature and flavor: pungent, hot, there is the effect of warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding, be used for the treatment of that nosebleed metrorrhagia is vomited and diarrhoea, told to Deficiency and coldness of spleen and stomach, stomachache, yang deficiency is lost blood;
Semen Persicae, nature and flavor: bitter sweet, flat, the effect that has blood stasis removing and clots absorbing, moisturizes laxation, is used for the treatment of amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood;
Herba Schizonepetae, nature and flavor: pungent, tepor, there is the effect of induce sweat loose wind, rash, be used for the treatment of flu, headache, measles, rubella, skin infection from the beginning of, parch to black treating hematochezia, metrorrhagia, puerperal blood faints;
Herba Leonuri, nature and flavor: acrid in the mouth is bitter, cool, have the effect of invigorate blood circulation, dispel silt, regulating menstruation, the water that disappears, and are used for the treatment of menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rush down blood, carbuncle skin infection;
While taking, first, by fried good herb liquid potion every day, the morning, noon and afternoon service once, 200 milliliters/time of dosages, taking medicine after meal.This medicine is to take common Chinese herbal medicine as raw material, there is advantages of perfect compatibility, make a general survey of full side, the efficacy of a drug is powerful, the pathogenesis that hits, and has fully demonstrated blood circulation promoting and blood stasis dispelling, nourishing blood and invigorating qi, hard masses softening and resolving, promoting the flow of QI in the collateral by warming the meridian, promoting blood flow to regulate menstruation, blood-enriching and blood-promoting circulation, pleasant pain relieving, has drawn blood and return through, the Therapeutic Principle that concocts all medicines.
The specific embodiment
Below embodiments of the present invention are described in detail
The clinical manifestation of hysteromyoma and hypertrophy of uterus has similarity, if hysteromyoma is between single flesh wall or mucosa lower time, its palace body also shows as even increase, now be difficult for differentiating with hypertrophy of uterus, but hysteromyoma and hypertrophy of uterus are two kinds of different diseases after all, respectively have its own corresponding characteristicness, the main distinction is as follows: A, morbidity crowd, hysteromyoma is the modal benign tumors of female sex organs, is common in the women of 30~50 years old, and within 20 years old, following person is comparatively rare; Hypertrophy of uterus is more common in puerpera, and sick time is long, and the many persons of the amount of bleeding are anemia looks.B, clinical manifestation, hysteromyoma: how asymptomatic patient is, small number of patients can show as vaginal hemorrhage, abdominal mass and pressure symptom, muscular tumor not of uniform size, differ greatly, large person can reach tens of kilograms, the little situation that even can occur that tens or several hundred muscular tumors are grown simultaneously; Hypertrophy of uterus: typical clinical manifestation is leucorrhoea grow in quantity, the lighter can be without General Symptoms, when inflammation is diffused into pelvic cavity along jarjavay's ligaments, can there is waist and sacrum pain, the symptoms such as the sense of hypogastric region falling inflation and dysmenorrhea often increase the weight of when defecation, sexual intercourse, compare with hysteromyoma, during hypertrophy of uterus, uterus is evenly to increase, seldom period of greater than two months gravid uterus.
The present invention is exactly a kind of Chinese herbal medicine formula proposing for the treatment of above-mentioned hysteromyoma and hypertrophy of uterus, adopts the herb liquid good drug efficacy of this formula preparation, and treatment cycle is short, instant effect, cure rate is high, is difficult for recurrence, toxic and side effects is little, can effectively effect a radical cure above-mentioned hysteromyoma and hypertrophy of uterus.Below specific embodiment provided by the present invention is described in detail.
Embodiment 1:
Select 48 grams of high-quality clean 15 grams of 15 grams, 6 grams of 6 grams of 30 grams of 15 grams of 40 grams of Radix Angelicae Sinensis, the Radixs Linderae, Rhizoma Chuanxiongs, Radix Glycyrrhizae Preparatas, Rhizoma Zingiberis Preparatums, Semen Persicae, Herba Schizonepetaes and Herba Leonuris, be ground into respectively graininess (granularity is 5mm-6mm) standby; Pack the granular medicament crushing in cloth bag tying, prior to soaking 40-50 minute in cold boiled water, to soak into medicine degree of being organized as, then put in boiling machine, inject appropriate cold boiled water, with high heat after fried boiling, change slow fire fried 55 minutes, until medicine fried good after, be condensed into 1800 milliliters of 50% herb liquids, pack sealing.While taking, by fried good herb liquid potion every day, the morning, noon and afternoon service once, 200 milliliters/time of dosages, and taking medicine after meal, can fully recover for 32 doses.
Embodiment 2:
Select 40 grams of high-quality clean 10 grams of 10 grams, 5 grams of 5 grams of 20 grams of 10 grams of 30 grams of Radix Angelicae Sinensis, the Radixs Linderae, Rhizoma Chuanxiongs, Radix Glycyrrhizae Preparatas, Rhizoma Zingiberis Preparatums, Semen Persicae, Herba Schizonepetaes and Herba Leonuris, be ground into respectively graininess (granularity is 5mm-6mm) standby; Pack the granular medicament crushing in cloth bag tying, prior to soaking 40-50 minute in cold boiled water, to soak into medicine degree of being organized as, then put in boiling machine, inject appropriate cold boiled water, with high heat after fried boiling, change slow fire fried 55 minutes, until medicine fried good after, be condensed into 1800 milliliters of 50% herb liquids, pack sealing.While taking, by fried good herb liquid potion every day, the morning, noon and afternoon service once, 200 milliliters/time of dosages, and taking medicine after meal, can fully recover for 38 doses.
Embodiment 3:
Select 48 grams of high-quality clean 15 grams of 15 grams, 6 grams of 6 grams of 30 grams of 15 grams of 40 grams of Radix Angelicae Sinensis, the Radixs Linderae, Rhizoma Chuanxiongs, Radix Glycyrrhizae Preparatas, Rhizoma Zingiberis Preparatums, Semen Persicae, Herba Schizonepetaes and Herba Leonuris, be ground into respectively graininess (granularity is 5mm-6mm) standby; Pack the granular medicament crushing in cloth bag tying, prior to soaking 40-50 minute in cold boiled water, to soak into medicine degree of being organized as, then put in boiling machine, inject appropriate cold boiled water, with high heat after fried boiling, change slow fire fried 55 minutes, until medicine fried good after, be condensed into 1800 milliliters of 50% herb liquids, pack sealing.While taking, by fried good herb liquid potion every day, the morning, noon and afternoon service once, 200 milliliters/time of dosages, and taking medicine after meal, can fully recover for 31 doses.
Embodiment 4:
Select 40 grams of high-quality clean 10 grams of 10 grams, 5 grams of 5 grams of 20 grams of 10 grams of 30 grams of Radix Angelicae Sinensis, the Radixs Linderae, Rhizoma Chuanxiongs, Radix Glycyrrhizae Preparatas, Rhizoma Zingiberis Preparatums, Semen Persicae, Herba Schizonepetaes and Herba Leonuris, be ground into respectively graininess (granularity is 5mm-6mm) standby; Pack the granular medicament crushing in cloth bag tying, prior to soaking 40-50 minute in cold boiled water, to soak into medicine degree of being organized as, then put in boiling machine, inject appropriate cold boiled water, with high heat after fried boiling, change slow fire fried 55 minutes, until medicine fried good after, be condensed into 1800 milliliters of 50% herb liquids, pack sealing.While taking, by fried good herb liquid potion every day, the morning, noon and afternoon service once, 200 milliliters/time of dosages, and taking medicine after meal, can fully recover for 37 doses.
The present invention is through the treatment to hundreds of routine patients, and therapeutic effect is remarkable, and toxic and side effects is little, and part allusion quotation shape case is as follows.
1, patient: Xiao XX, female, 42 years old, address: Chengdu, Sichuan Province
Illness symptom: closely for a period of time, preceeded menorrhea, amount is many, coloured purple clot, menstrual period lower abdominal pain, waist is tired, little sleep disturbed by dreams is vexed uncomfortable in chest, checks anteversion of uterus 7 * 6cm, prolapse, activity, in matter, without tenderness, is " hysteromyoma " after diagnosing.
Treatment: give top " decoction medicine ", and add Poria, Caulis Polygoni Multiflori etc. up, every day 3 times, the check after 15 doses of taking medicine, oligemia, stomachache is also slow, advises it to renew and takes after 21 doses, and uterus is reduced into 6.2 * 4cm, movable good, in matter, transference cure and fully recovering.Follow up a case by regular visits to no abnormality seen 2 years.
2, patient: Guo XX, female, 33 years old, address: Xichang City, Sichuan Province
Illness symptom: patient has excessive menstruation more than 3 years, sometimes blood flow is as gushed, great majority were passed through the time over 8 days, in the past always by " anovulatory dysfunctional uterine hemorrhage " treatment, effect is poor, this time by Gynaecological B ultrasound inspection, finds, uterus evenly increases, appearance as conceived 2-3 month, is diagnosed as " hypertrophy of uterus ".
Treatment: give top " decoction medicine ", and add Poria, Caulis Polygoni Multiflori etc., every day 3 times, the check after 10 doses of taking medicine, reduces through amount, and symptom is also slow, advises it to renew and takes after 26 doses, and symptom all disappears, and recovery from illness.Follow up a case by regular visits in the eumenorrhea, 4.
3, patient: the XX of the Qin, female, 38 years old, address: Ziyang City, Sichuan Province
Illness symptom: since recent months, preceeded menorrhea, continues countless prolongations, and, little sleep disturbed by dreams, vexed uncomfortable in chest tired with the purple clot of color, few abdomen pain, waist, be: hysteromyoma after diagnosing.
Treatment: give top " decoction medicine ", and up, add Poria, Caulis Polygoni Multiflori etc., every day 3 times, the check after 20 doses of taking medicine, menses reduce, and stomachache disappears, and advises it to renew and takes after 16 doses, and gynecologial examination is: all diseases disappear.Visit 3 year, tell its eumenorrhea after drug withdrawal.
4, patient: Zhu XX, female, 29 years old, address: the Da Zhoushi of Sichuan Province
Illness symptom: excessive menstruation for many years, sometimes blood goes out as gushed, the great majority time of passing through surpasses 8-9 days, but busy because of farm work, does not mind, by " anovulatory dysfunctional uterine hemorrhage ", cured afterwards always, poor effect, finds through ultrasound diagnosis, uterus evenly increases, appearance as conceived 3 months, is diagnosed as " hypertrophy of uterus ".
Treatment: give top " decoction medicine ", every day 3 times, the check after 15 doses of taking medicine, reduces through amount, and transference cure is more than half, advises it to renew and takes after more than 20 agent, transference cure and fully recovering.Follow up a case by regular visits to no abnormality seen 1 year.
5, patient: Du XX, female, 41 years old, address: Xinjin County, Sichuan Province
Illness symptom: patient feels few abdomen pain, menoxenia, vagina has irregular bleeding, recently the pain increased for left lower quadrant, and menses are more, and with stasis of blood piece, soreness of the waist and knees, fatigue and weak, frequent micturition, go gynecologial examination: pudendum is normal, the courageous and upright secretions of the residual a small amount of pitchy of intravaginal, uterus was as three months gestation sizes, uterine probe is surveyed uterine cavity, and cavity of uterus shoals, and has enclosed mass in utero outstanding, palace body is slightly partial to right side, is diagnosed as " hysteromyoma ".
Treatment: give top " decoction medicine ", and up, add Poria, Caulis Polygoni Multiflori etc., every day 3 times, the check after 20 doses of taking medicine, menses reduce, and stomachache disappears, and advises it to renew and takes after 17 doses, and gynecologial examination is: all diseases disappear, and recovery from illness.Follow up a case by regular visits to 1 year, have no recurrence.

Claims (3)

1. a decoction medicine for the treatment of hysteromyoma and hypertrophy of uterus, is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Radix Angelicae Sinensis 1-4 part;
Radix Linderae 1-4 part;
Rhizoma Chuanxiong 1-4 part;
Radix Glycyrrhizae Preparata 1-4 part;
Rhizoma Zingiberis Preparatum 1-4 part;
Semen Persicae 1-4 part;
Herba Schizonepetae 1-4 part;
Herba Leonuri 1-4 part.
2. the decoction medicine for the treatment of hysteromyoma according to claim 1 and hypertrophy of uterus, is characterized in that, each component of described medicine and mass parts thereof are than as follows:
2 parts of Radix Angelicae Sinensis;
2 parts of the Radixs Linderae;
2 parts of Rhizoma Chuanxiongs;
2 parts of Radix Glycyrrhizae Preparatas;
2 parts of Rhizoma Zingiberis Preparatums;
2 parts, Semen Persicae;
2 parts of Herba Schizonepetaes;
2 parts of Herba Leonuris.
3. decoction medicine and the preparation method of the treatment hysteromyoma described in claim 1 or 2 and hypertrophy of uterus, is characterized in that, described method comprises the steps:
A, according to mass parts than selecting clean Radix Angelicae Sinensis, the Radix Linderae, Rhizoma Chuanxiong, Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Preparatum, Semen Persicae, Herba Schizonepetae and the Herba Leonuri of high-quality, be ground into respectively graininess (granularity is 5mm-6mm) standby;
B, pack the granular medicament crushing in cloth bag tying, prior to soaking 40-50 minute in cold boiled water, to soak into medicine degree of being organized as, then put in boiling machine, inject appropriate cold boiled water, with high heat after fried boiling, change slow fire fried 55 minutes, until medicine fried good after, be condensed into 1800 milliliters of 50% herb liquids, pack sealing.
CN201410423660.0A 2014-08-26 2014-08-26 Medical decoction for treating uterine fibroids and hypertrophy of uterus and preparation method thereof Pending CN104173981A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815082A (en) * 2015-04-15 2015-08-05 成都市飞龙水处理技术研究所青白江第一分所 Orally-taken medicine for treating uterus development malignancy infertility and preparing method thereof
CN105381452A (en) * 2015-11-16 2016-03-09 游莲莲 Pharmaceutical composition for treating hypertrophy of uterus caused by blood heat and preparation method of pharmaceutical composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
郑彬等: "生化汤在妇科病中的运用", 《贵阳中医学院学报》 *
郭惠敏 等: "《当代肿瘤科名方验方大全》", 30 June 2011 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815082A (en) * 2015-04-15 2015-08-05 成都市飞龙水处理技术研究所青白江第一分所 Orally-taken medicine for treating uterus development malignancy infertility and preparing method thereof
CN105381452A (en) * 2015-11-16 2016-03-09 游莲莲 Pharmaceutical composition for treating hypertrophy of uterus caused by blood heat and preparation method of pharmaceutical composition

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Application publication date: 20141203