CN105362469A - Traditional Chinese medicine for treating migraine and preparation method thereof - Google Patents
Traditional Chinese medicine for treating migraine and preparation method thereof Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 208000019695 Migraine disease Diseases 0.000 title abstract description 10
- 206010027599 migraine Diseases 0.000 title abstract description 10
- 239000009636 Huang Qi Substances 0.000 claims abstract description 10
- 238000011282 treatment Methods 0.000 claims description 14
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Abstract
The invention relates to a traditional Chinese medicine for treating migraine and a preparation method thereof. The traditional Chinese medicine comprises the following components by weight: 3-8 parts of Chinese wolfberry, 5-10 parts of chrysanthemum, 3-6 parts of radix rehmanniae, 5-8 parts of radix bupleuri, 3-8 parts of root of herbaceous peony, 2-5 parts of radix angelicae, 3-8 parts of mint, 5-10 parts of radix sileris, 3-5 parts of Ligusticum wallichii, 3-5 parts of periostracum cicadae, 5-8 parts of Chinese angelica, 1-5 parts of Herba schizonepetae, 2-6 parts of Poria cocos, 3-6 parts of retinervus luffae fructus, 3-8 parts of Radix Astragali and 2-5 parts of licorice. The medicines cooperatively play the roles of dispelling wind, eliminating dampness, activating collaterals, promoting blood circulation and relieving pain.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of migraine and preparation method thereof.
Background technology
Migraine (migraine) is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%, often has genetic background.
Frequent Migraine outbreak will affect the life and work of patient, be exactly the most directly affect sleep, because do not have enough sleep, daytime, work was also greatly affected just out of spirits.And have some patients to be usually once the outbreak that works, extremely delay thing.Meanwhile, people suffers from headaches disease for a long time, and personality changes, and often disposition becomes irascible.Again because obstinate, life is subject to significant impact, and weak in mind, lose confidence, the time has been grown and will have a negative impact to the cardiovascular and cerebrovascular vessel of people, cerebral thrombosis after Headache attacks clinically, hypertension, and cerebral hemorrhage is clinical also more common.
Migrainous therapeutic purposes alleviate or stop Headache attacks, alleviates concomitant symptom, prevention headache recurrence.Treatment comprises Drug therapy and non-drug therapy two aspects.Non-drug therapy mainly physiotherapy can be taked with magnetic therapy, oxygen therapy, psychological counseling, and relieving stress, the life style of keeping fit, avoids various migraine inducement.Drug treatment is divided into stage of attack to treat and prophylactic treatment.The treatment of stage of attack, in order to obtain optimum curative effect, should be taken medicine when symptom is initial usually immediately.Medicine comprises non-specific analgesic as nonsteroidal antiinflammatory drug (NSAIDs) and opioid drug, and specific drug is as Ergota class preparation and Qu Putan class medicine.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine for the treatment of migraine, curative effect is reliable, not easily recurs.
The present invention is realized by following technical scheme:
One treats migrainous Chinese medicine, is made up of the raw material of following weight portion:
Fructus Lycii 3-8 part, Flos Chrysanthemi 5-10 part, Radix Rehmanniae 3-6 part, Radix Bupleuri 5-8 part, Radix Paeoniae Alba 3-8 part, Radix Angelicae Dahuricae 2-5 part, Herba Menthae 3-8 part, Radix Saposhnikoviae 5-10 part, Rhizoma Chuanxiong 3-5 part, Periostracum Cicadae 3-5 part, Radix Angelicae Sinensis 5-8 part, Herba Schizonepetae 1-5 part, Poria 2-6 part, Retinervus Luffae Fructus 3-6 part, Radix Astragali 3-8 part, Radix Glycyrrhizae 2-5 part.
Preferably, be made up of the raw material of following weight portion: Fructus Lycii 8 parts, Flos Chrysanthemi 5 parts, 6 parts, the Radix Rehmanniae, Radix Bupleuri 8 parts, the Radix Paeoniae Alba 3 parts, the Radix Angelicae Dahuricae 5 parts, Herba Menthae 3 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 5 parts, Periostracum Cicadae 3 parts, Radix Angelicae Sinensis 8 parts, Herba Schizonepetae 5 parts, 6 parts, Poria, Retinervus Luffae Fructus 3 parts, the Radix Astragali 3 parts, 2 parts, Radix Glycyrrhizae.
Preferably, be made up of the raw material of following weight portion: Fructus Lycii 3 parts, Flos Chrysanthemi 10 parts, 3 parts, the Radix Rehmanniae, Radix Bupleuri 5 parts, the Radix Paeoniae Alba 8 parts, the Radix Angelicae Dahuricae 2 parts, Herba Menthae 8 parts, Radix Saposhnikoviae 5 parts, Rhizoma Chuanxiong 3 parts, Periostracum Cicadae 5 parts, Radix Angelicae Sinensis 5 parts, Herba Schizonepetae 1 part, 2 parts, Poria, Retinervus Luffae Fructus 6 parts, the Radix Astragali 8 parts, 5 parts, Radix Glycyrrhizae.
The present invention also provides the method preparing above-mentioned Chinese medicine composition, after Chinese medicine is pressurizeed, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
Instructions of taking of the present invention is, potion, divided and sooner or later took every day.
In the present invention, Fructus Lycii, nourishing the liver and kidney, replenishing vital essence to improve eyesight, lung moistening.Flos Chrysanthemi, soothing the liver improving eyesight, treatment headache, dizzy.Radix Rehmanniae Preparata, enriching yin and nourishing kidney, menstruation regulating blood nourishing medicinal, treatment headache due to deficiency of blood.Radix Bupleuri, expelling pathogenic factors from the exterior is brought down a fever, reconciling superficies and interior.The Radix Paeoniae Alba, nourishing blood to suppress the hyperactive liver, clear and coherent blood vessels, slow middle pain relieving.The Radix Angelicae Dahuricae, dispels the wind, dampness.Herba Menthae, wind-dispelling heat-dissipating.Radix Saposhnikoviae, expelling wind and removing dampness, dispersing cold for relieving pain.Rhizoma Chuanxiong, activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain.Periostracum Cicadae, wind-dispelling heat-dissipating.Radix Angelicae Sinensis, enrich blood invigorate blood circulation, dredge the meridian passage.Herba Schizonepetae, expelling wind and removing dampness, dispersing cold for relieving pain.Poria, treats dizzy cardiopalmus.Retinervus Luffae Fructus, dispelling wind and removing obstruction in the collateral.The Radix Astragali, invigorating QI to consolidate the body surface resistance.Radix Glycyrrhizae, QI invigorating invigorating middle warmer, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Expelling wind and removing dampness instrumental ensembled by all medicines, the effect of dredge the meridian passage, promoting blood circulation and stopping pain.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1:
Treat migrainous Chinese medicine, be made up of the raw material of following weight portion: Fructus Lycii 8 parts, Flos Chrysanthemi 5 parts, 6 parts, the Radix Rehmanniae, Radix Bupleuri 8 parts, the Radix Paeoniae Alba 3 parts, the Radix Angelicae Dahuricae 5 parts, Herba Menthae 3 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 5 parts, Periostracum Cicadae 3 parts, Radix Angelicae Sinensis 8 parts, Herba Schizonepetae 5 parts, 6 parts, Poria, Retinervus Luffae Fructus 3 parts, the Radix Astragali 3 parts, 2 parts, Radix Glycyrrhizae.By Chinese medicine pressurize after, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
Embodiment 2:
Treat migrainous Chinese medicine, be made up of the raw material of following weight portion: Fructus Lycii 3 parts, Flos Chrysanthemi 10 parts, 3 parts, the Radix Rehmanniae, Radix Bupleuri 5 parts, the Radix Paeoniae Alba 8 parts, the Radix Angelicae Dahuricae 2 parts, Herba Menthae 8 parts, Radix Saposhnikoviae 5 parts, Rhizoma Chuanxiong 3 parts, Periostracum Cicadae 5 parts, Radix Angelicae Sinensis 5 parts, Herba Schizonepetae 1 part, 2 parts, Poria, Retinervus Luffae Fructus 6 parts, the Radix Astragali 8 parts, 5 parts, Radix Glycyrrhizae.By Chinese medicine pressurize after, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
Medicinal liquid embodiment 1 prepared has carried out clinical trial, specific as follows:
1, clinical data
1 physical data: 50 routine migraineurs, is divided into treatment group and matched group by this 50 routine patient, wherein in treatment group man 10 example, female 15 example, the age 17-62 year; In matched group man 12 example, female 13 example, the age 18-60 year.The no significant difference such as two groups of ages, sex and headache severities, have comparability.The location sign of equal impassivity system of having a medical check-up, and all check through head CT or MRI, do not find intracranial organic disease, and get rid of the headache caused by other organic diseases such as hypertension and nose, eye, oral cavity, cervical vertebra simultaneously.Headache position is two temporo sides 23 examples, two temporo side and forehead 10 example, occipitalia pain l0 example, full headache 7 example.The course of disease is 3 months-8 years, monthly at least shows effect 3 times.According to the diagnostic criteria that nineteen ninety international migraine meeting is formulated, divide level Four by headache severity: I level (mild headache): during outbreak, headache is slight, and neuro-vegetative response is not obvious, and daily routines are unaffected; II level (moderate pain): have a headache heavier, with slight neuro-vegetative response, daily routines are slightly influenced, and its involved is no more than 50%; III grade (severe headache): headache degree overweights moderate pain, affects daily routines more than 50%, but need not lie up; IV grade (severe headache): during Headache attacks, neuro-vegetative response is obvious, must lie in bed.
2, Therapeutic Method
Treatment group adopts the Chinese medicine of the present embodiment 1, and potion, divided and sooner or later took every day.
Matched group takes flunarizine 5mg before adopting and sleeping every night.Two groups all treat 8-12 week after carry out efficacy evaluation and follow-up.
3, therapeutic outcome
3.1 criterion of therapeutical effect
(1) cure: after taking medicine 1 week, headache and simultaneous phenomenon disappear, and stablize and do not recur half a year more than;
(2) effective: headache and simultaneous phenomenon are clearly better, attack times reduces;
(3) effective: headache degree and simultaneous phenomenon alleviate, attack times reduces;
(4) invalid: headache degree, simultaneous phenomenon and attack times is all unchanged.
3.2 therapeutic outcome
Matched group has 12 examples to cure, and 5 examples are effective, and effectively, 3 examples are invalid for 5 examples.Total effective rate 88%, cure rate 48%.
Treatment group has 23 examples to cure, and 1 example is effective, and 1 example effectively, is all followed up a case by regular visits to, without recurrence.Total effective rate 100%, cure rate 92%.Be very effective.
3.3 toxic and side effects
Before and after treatment, routine blood test, routine urinalysis, hepatic and renal function are without significant change, illustrate that Chinese medicine of the present invention is to human body non-evident effect, long-term taking safety.
Claims (4)
1. treat a migrainous Chinese medicine, be made up of the raw material of following weight portion:
Fructus Lycii 3-8 part, Flos Chrysanthemi 5-10 part, Radix Rehmanniae 3-6 part, Radix Bupleuri 5-8 part, Radix Paeoniae Alba 3-8 part, Radix Angelicae Dahuricae 2-5 part, Herba Menthae 3-8 part, Radix Saposhnikoviae 5-10 part, Rhizoma Chuanxiong 3-5 part, Periostracum Cicadae 3-5 part, Radix Angelicae Sinensis 5-8 part, Herba Schizonepetae 1-5 part, Poria 2-6 part, Retinervus Luffae Fructus 3-6 part, Radix Astragali 3-8 part, Radix Glycyrrhizae 2-5 part.
2. one as claimed in claim 1 treats migrainous Chinese medicine, is made up of the raw material of following weight portion:
Fructus Lycii 8 parts, Flos Chrysanthemi 5 parts, 6 parts, the Radix Rehmanniae, Radix Bupleuri 8 parts, the Radix Paeoniae Alba 3 parts, the Radix Angelicae Dahuricae 5 parts, Herba Menthae 3 parts, Radix Saposhnikoviae 10 parts, Rhizoma Chuanxiong 5 parts, Periostracum Cicadae 3 parts, Radix Angelicae Sinensis 8 parts, Herba Schizonepetae 5 parts, 6 parts, Poria, Retinervus Luffae Fructus 3 parts, the Radix Astragali 3 parts, 2 parts, Radix Glycyrrhizae.
3. one as claimed in claim 1 treats migrainous Chinese medicine, is made up of the raw material of following weight portion:
Fructus Lycii 3 parts, Flos Chrysanthemi 10 parts, 3 parts, the Radix Rehmanniae, Radix Bupleuri 5 parts, the Radix Paeoniae Alba 8 parts, the Radix Angelicae Dahuricae 2 parts, Herba Menthae 8 parts, Radix Saposhnikoviae 5 parts, Rhizoma Chuanxiong 3 parts, Periostracum Cicadae 5 parts, Radix Angelicae Sinensis 5 parts, Herba Schizonepetae 1 part, 2 parts, Poria, Retinervus Luffae Fructus 6 parts, the Radix Astragali 8 parts, 5 parts, Radix Glycyrrhizae.
4. preparation as arbitrary in claim 1-3 as described in a kind of method for the treatment of migrainous Chinese medicine, it is characterized in that:
By Chinese medicine pressurize after, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
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