CN105521128A - Traditional Chinese medicinal composition for treating furuncle as well as preparation method and application of traditional Chinese medicinal composition - Google Patents

Traditional Chinese medicinal composition for treating furuncle as well as preparation method and application of traditional Chinese medicinal composition Download PDF

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CN105521128A
CN105521128A CN201610024053.6A CN201610024053A CN105521128A CN 105521128 A CN105521128 A CN 105521128A CN 201610024053 A CN201610024053 A CN 201610024053A CN 105521128 A CN105521128 A CN 105521128A
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herba
parts
chinese medicine
traditional chinese
furuncle
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傅智炫
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傅智炫
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a traditional Chinese medicinal composition for treating furuncle, and belongs to the field of traditional Chinese medicine treatment of the furuncle. The invention firstly discloses a traditional Chinese medicinal composition for treating furuncle, wherein the traditional Chinese medicinal composition consists of the following medicinal raw materials: herba hydrocotyles, herba centellae, creeping rostellularia herb, herba oxalidis corniculatae, rhizoma polygoni cuspidate, achyranthes longifolia mak, herba melastomatis dodecandri and houttuynia cordata. The traditional Chinese medicinal composition disclosed by the invention, by virtue of a conventional traditional Chinese medicinal preparation method, is prepared into an appropriate clinical preparation. The traditional Chinese medicinal composition disclosed by the invention has functions of diminishing inflammation, dispelling wind and eliminating dampness, activating blood and removing stasis, healing sore and promoting tissue regeneration; and on the basis of clinical curative effect, the traditional Chinese medicinal composition disclosed by the invention, on the furuncle, is concrete and reliable in curative effect, safe in clinical safety and free from any toxic and side effects, and the traditional Chinese medicinal composition is capable of treating both symptoms and root causes.

Description

Chinese medicine composition for the treatment of furuncle and phyma and its preparation method and application
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of furuncle and phyma and its production and use, belong to the treatment by Chinese herbs field of furuncle and phyma.
Background technology
Furuncle and phyma is the infection of a kind of suppurative hair follicle and hair follicle deep surrounding tissue.Furuncle and phyma may by bacteriological infection, air or food anaphylaxis, life stress, health is not eaten, sick, resistance is poor, some drugs, the factors such as too much junk food, wound infection, septicemia or thyroid defect of eating cause.It both pain and unbecoming, sometimes also can scar, once in a while even dangerous property.Though furuncle and phyma is not very serious disease, but because closely adjacent between hair follicle, if process the furuncle and phyma grown not in time, not only hurt like hell, and the infection easily causing surrounding skin, can grow more furuncle and phyma.
At present, western medical treatment furuncle and phyma means are varied, but often less effective, side effect is larger.Therefore, develop a kind of Chinese medicine composition furuncle and phyma to definite therapeutic effect, will significant application value be had.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of furuncle and phyma, and this Chinese medicine composition is fast to responding well to treatment of furuncle and phyma, determined curative effect, have no side effect.
Another technical problem to be solved by this invention is to provide a kind of preparation method of described Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
First the present invention discloses a kind of Chinese medicine composition for the treatment of furuncle and phyma, comprises following crude drug: Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae.
The weight portion of each crude drug is: Herba Hydrocotyles 70-80 part, Herba Centellae 70-80 part, Herba Rostellulariae 60-70 part, Herba Oxalidis Corniculatae 60-70 part, Rhizoma Polygoni Cuspidati 30-40 part, Radix Achyranthis 30-40 part, Herba Melastomatis Dodecandri 10-20 part, Herba Houttuyniae 10-20 part;
Preferably, the weight portion of each crude drug is: Herba Hydrocotyles 75 parts, Herba Centellae 75 parts, Herba Rostellulariae 65 parts, Herba Oxalidis Corniculatae 65 parts, Rhizoma Polygoni Cuspidati 35 parts, Radix Achyranthis 35 parts, Herba Melastomatis Dodecandri 15 parts, Herba Houttuyniae 15 parts.
Herba Hydrocotyles is the herb of samphire Herba Hydrocotyles, cleans, dries in the shade or using fresh herb.Nature and flavor: toil, cold.Function cures mainly: heat clearing away, diuresis, detumescence, removing toxic substances.Harness the Yellow River subcutaneous ulcer, dysentery, gonorrhea, dysuria, corneal nebula, larynx swells, carbuncle furuncle, traumatic injury congestive edema.For acute icterohepatitis, acute nephritis, pertussis, lithangiuria, tinea pedis, herpes zoster, conjunctivitis, erysipelas.
Herba Centellae is herb or the whole herb with root of samphire Herba Centellae.Nature and flavor: toil, cold.Enter liver,spleen,kidney warp.Function cures mainly: clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Control eruptive disease stomachache, diarrhea due to summer-heat, dysentery, jaundice due to damp-heat, sand Stranguria, stranguria with blood, tells, is defeated in battle, hemoptysis, conjunctival congestion, and larynx swells, rubella, scabies, furuncle carbuncle poison, traumatic injury.
Herba Rostellulariae is the herb of acanthaceous plant Herba Rostellulariae.Nature and flavor: salty pungent, cold.Enter liver, gallbladder two warp.Function cures mainly: heat-clearing and toxic substances removing, and dampness removing disappears stagnant, promoting blood circulation and stopping pain.Cure cold heating, cough, laryngalgia, malaria, dysentery, jaundice, nephritis edema, bones and muscles pain, infantile malnutrition, carbuncle furuncle, traumatic injury.
Herba Oxalidis Corniculatae is the oxalic herb of Oxalidaceae plant.Nature and flavor: acid, cold.Start with sun bright, Taiyang channel.Function cures mainly: clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis, subduing swelling and detoxicating.Control and have loose bowels, dysentery, jaundice, gonorrhea, leucorrhea with red and white discharge, measles, spit blood, epistaxis, laryngopharynx swelling and pain, furuncle, carbuncle, scabies, haemorrhoids, proctoptosis, traumatic injury, burn.
Rhizoma Polygoni Cuspidati is the rhizome of polygonaceae plant Rhizoma Polygoni Cuspidati.Nature and flavor: bitter are flat.Function cures mainly: dispel the wind, dampness removing, and removing blood stasis with potent drugs stimulates the menstrual flow.Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia.Injury from falling down, scalds, malignant boil tinea disease.
Radix Achyranthis is the wild species of amaranthaceous plant Radix Achyranthis Bidentatae and the root welding technology of achyranthes longifolia Makino, coarse wool Radix Achyranthis Bidentatae etc.Nature and flavor: picric acid are flat.Function cures mainly: promoting blood circulation to remove blood stasis, and damp eliminating is favorable to the people, heat-clearing and toxic substances removing.Control gonorrhea, hematuria, women's amenorrhea, lump in the abdomen, rheumatic arthritis, beriberi, edema, dysentery, malaria, diphtheria, carbuncle, traumatic injury.
Herba Melastomatis Dodecandri is the herb of Melastomateae plants Herba Melastomatis Dodecandri.Nature and flavor: sweet in the mouth is micro-puckery, property is slightly cool.Enter liver,kidney,spleen, lung four warp.Function cures mainly: promoting blood circulation and hemostasis, heat-clearing and toxic substances removing.Control dysmenorrhea, puerperal abdonimal pain, metrorrhagia, leukorrhagia, have blood in stool, dysentery, carbuncle, furuncle.
Herba Houttuyniae is the aerial parts of saururaceae plant houttuynia cordata HouttuyniacordataThunb..Nature and flavor: cold nature, bitter in the mouth.Function cures mainly: heat-clearing and toxic substances removing, clear carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.
Chinese medicine composition of the present invention is based on the pathogenetic research of the deep layer of inventor to furuncle and phyma and Therapeutic Principle thereof, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, filter out the crude drug removing noxious dampness, dredge the meridian passage, form according to certain weight proportion prescription.
The present invention further discloses a kind of Chinese medicine composition for the treatment of furuncle and phyma, comprise following crude drug: Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri, Herba Houttuyniae, Stigma Maydis, Herba Duchesneae Indicae and Herba Senecionis Scandentis;
Preferably, the weight portion of each crude drug is: Herba Hydrocotyles 70-80 part, Herba Centellae 70-80 part, Herba Rostellulariae 60-70 part, Herba Oxalidis Corniculatae 60-70 part, Stigma Maydis 60-70 part, Herba Duchesneae Indicae 30-40 part, Rhizoma Polygoni Cuspidati 30-40 part, Radix Achyranthis 30-40 part, Herba Melastomatis Dodecandri 10-20 part, Herba Houttuyniae 10-20 part, Herba Senecionis Scandentis 10-20 part;
Most preferred, the weight portion of each crude drug is: Herba Hydrocotyles 75 parts, Herba Centellae 75 parts, Herba Rostellulariae 65 parts, Herba Oxalidis Corniculatae 65 parts, Stigma Maydis 65 parts, Herba Duchesneae Indicae 35 parts, Rhizoma Polygoni Cuspidati 35 parts, Radix Achyranthis 35 parts, Herba Melastomatis Dodecandri 15 parts, Herba Houttuyniae 15 parts, Herba Senecionis Scandentis 15 parts.
Stigma Maydis is the zeistic style of grass.Nature and flavor: sweet are flat.Function cures mainly: diuresis, expels the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting.Control oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, acute mastitis.
Herba Duchesneae Indicae is Compositae Herba Duchesneae Indicae platymiscium Herba Duchesneae Indicae Emiliasonchifolia (L.) DC., with all herbal medicine.Nature and flavor: cool, micro-hardship.Function cures mainly: heat-clearing and toxic substances removing, antiinflammatory, diuresis.For enteritis, dysentery, urinary tract infection, upper respiratory tract infection, conjunctivitis, oral ulcer, carbuncle sore.
Herba Senecionis Scandentis is the herb of feverfew Herba Senecionis Scandentis.Nature and flavor: bitter, cold.Function cures mainly: heat clearing away, removing toxic substances, parasite killing, improving eyesight.Control various acute inflammatory disease, wind-fire acute conjunctivitis, corneal nebula, typhoid fever, bacillary dysentery, lobar pneumonia, tonsillitis, enteritis, jaundice, influenza, toxemia, septicemia, carbuncle furuncle poison, dry exudative dermatitis skin ulcer, erysipelas, eczema, scalds, trichomonal vaginitis.For anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema furuncle.
The Chinese medicine composition that the present invention is prepared by Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae has certain therapeutic effect to furuncle and phyma, and effective percentage reaches 71.1%.The basis of Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae with the addition of following 6 groups of medicines respectively: (1) Stigma Maydis, Herba Duchesneae Indicae, Herba Senecionis Scandentis; (2) Radix Glycyrrhizae, Herba Dendranthematis indici, Rhizoma Coptidis; (3) Radix Et Rhizoma Rhei, the Radix Rehmanniae, Herba Violae; (4) Herba Taraxaci, Cortex Phellodendri, the Radix Angelicae Dahuricae; (5) Radix Saposhnikoviae, Radix Scutellariae, Radix Paeoniae Rubra; (6) Flos Lonicerae, Herba Plantaginis, Herba Hedyotidis Diffusae; Above-mentioned 6 groups of pharmaceutical compositions are prepared Chinese medicine composition respectively, investigates its therapeutic effect to furuncle and phyma.Experimental result shows, Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae basis is added Stigma Maydis, Herba Duchesneae Indicae, Herba Senecionis Scandentis to the effective percentage of patient up to 97.8%, is significantly higher than other combination.Illustrate that Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae have definite Synergistic effect together with Stigma Maydis, Herba Duchesneae Indicae, Herba Senecionis Scandentis compatibility, effectively improve the effective percentage for the treatment of furuncle and phyma.By contrast, after Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae are together with other several drugs compatibility, not obvious for the effect improving furuncle and phyma therapeutic effect.
The each medicine compatibility of the present invention plays effect of antiinflammatory, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, expelling pus and promoting granulation together.Chinese medicine composition of the present invention is for furuncle and phyma treating both the principal and secondary aspects of a disease, and clinical observation on the therapeutic effect confirms, Chinese medicine composition of the present invention is reliable for furuncle and phyma determined curative effect, true.Chinese medicine composition of the present invention is nontoxic, safe and reliable, has no adverse reaction after taking, Clinical practice safety.
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
In the present invention on drug composition basis, the adjuvant that interpolation is suitable or carrier are prepared into the suitable clinical preparation for the treatment of furuncle and phyma according to Chinese medicine conventional formulation method; Be preferably oral formulations.
Described oral formulations comprises pill, powder, granule, capsule, tablet, oral liquid or drop pill.
Described carrier or adjuvant refer to carrier or the adjuvant of pharmaceutical field routine, such as: diluent, agent of bursting apart, lubricant, excipient, binding agent, fluidizer, filler, surfactant etc.; In addition, other adjuvant can also be added in the composition, as flavouring agent and sweeting agent.Described diluent can be that one or more increase the composition of tablet weight and volume, and conventional diluent comprises lactose, starch, pregelatinized Starch, microcrystalline Cellulose, sorbitol, mannitol and inorganic calcium salt etc.; Wherein the most frequently used is lactose, starch, microcrystalline Cellulose.Described disintegrating agent can be crospolyvinylpyrrolidone, one or more mixture in cross-linking sodium carboxymethyl cellulose, alginic acid, microcrystalline Cellulose; Wherein with crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose is good.Described lubricant comprises stearic acid, sodium stearate, magnesium stearate, calcium stearate, Polyethylene Glycol, Pulvis Talci, one or more mixture in hydrogenated vegetable oil; Wherein suitable with magnesium stearate.Described binding agent can be the composition that one or more are conducive to granulating; Can be starch slurry, hydroxypropyl emthylcellulose, polyvinylpyrrolidone be good with the ethanol water of polyvinylpyrrolidone.Described fluidizer can for one or more mixture in micropowder silica gel, Pulvis Talci, magnesium trisilicate.The composition that described surfactant can improve wettability for one or more and increase drug-eluting, commonly uses as sodium lauryl sulphate.
A kind of preparation method of Chinese medicine composition of the present invention, comprises the following steps: after being taken by described weight by each crude drug of the present invention, and pulverize, sieve (can be such as 200-300 mesh sieve), to obtain final product.Certainly, after also each crude drug can being pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared into required dosage form.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as age, health status of concrete dosage form, patient.As guidance: usage and dosage: pill, every ball pill is containing 0.4 gram of crude drug, at every turn oral 1 to 2 ball, and 2 times on the one 10 days is a course for the treatment of, generally takes 2-3 the course for the treatment of.
Technical solution of the present invention compared with prior art, has following beneficial effect:
The compatibility of Chinese medicine composition of the present invention is reasonable, can significantly improve the effective percentage for the treatment of furuncle and phyma, determined curative effect.Chinese medicine composition of the present invention is pure Chinese medicinal preparation, and treating both the principal and secondary aspects of a disease, has no side effect, and preparation technology is simple, has a good application prospect.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.It should be understood that described embodiment is only exemplary, any restriction is not formed to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments or replacement all fall into protection scope of the present invention.
The preparation of embodiment 1 pill
Each crude drug is taken: Herba Hydrocotyles 70g, Herba Centellae 70g, Herba Rostellulariae 60g, Herba Oxalidis Corniculatae 60g, Rhizoma Polygoni Cuspidati 30g, Radix Achyranthis 30g, Herba Melastomatis Dodecandri 10g, Herba Houttuyniae 10g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate refined honey, mixing, is prepared into the pill of every ball 4g.
The preparation of embodiment 2 pill
Each crude drug is taken: Herba Hydrocotyles 80g, Herba Centellae 80g, Herba Rostellulariae 70g, Herba Oxalidis Corniculatae 70g, Rhizoma Polygoni Cuspidati 40g, Radix Achyranthis 40g, Herba Melastomatis Dodecandri 20g, Herba Houttuyniae 20g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate refined honey, mixing, is prepared into the pill of every ball 4g.
The preparation of embodiment 3 pill
Each crude drug is taken: Herba Hydrocotyles 75g, Herba Centellae 75g, Herba Rostellulariae 65g, Herba Oxalidis Corniculatae 65g, Rhizoma Polygoni Cuspidati 35g, Radix Achyranthis 35g, Herba Melastomatis Dodecandri 15g, Herba Houttuyniae 15g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate refined honey, mixing, is prepared into the pill of every ball 4g.
The preparation of embodiment 4 pill
Each crude drug is taken: Herba Hydrocotyles 70g, Herba Centellae 70g, Herba Rostellulariae 60g, Herba Oxalidis Corniculatae 60g, Stigma Maydis 60g, Herba Duchesneae Indicae 30g, Rhizoma Polygoni Cuspidati 30g, Radix Achyranthis 30g, Herba Melastomatis Dodecandri 10g, Herba Houttuyniae 10g, Herba Senecionis Scandentis 10g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate refined honey, mixing, is prepared into the pill of every ball 4g.
The preparation of embodiment 5 pill
Each crude drug is taken by following weight; Herba Hydrocotyles 80g, Herba Centellae 80g, Herba Rostellulariae 70g, Herba Oxalidis Corniculatae 70g, Stigma Maydis 70g, Herba Duchesneae Indicae 40g, Rhizoma Polygoni Cuspidati 40g, Radix Achyranthis 40g, Herba Melastomatis Dodecandri 20g, Herba Houttuyniae 20g, Herba Senecionis Scandentis 20g; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate refined honey, mixing, is prepared into the pill of every ball 4g.
The preparation of embodiment 6 pill
Each crude drug is taken: Herba Hydrocotyles 75g, Herba Centellae 75g, Herba Rostellulariae 65g, Herba Oxalidis Corniculatae 65g, Stigma Maydis 65g, Herba Duchesneae Indicae 35g, Rhizoma Polygoni Cuspidati 35g, Radix Achyranthis 35g, Herba Melastomatis Dodecandri 15g, Herba Houttuyniae 15g, Herba Senecionis Scandentis 15g by following weight; Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate refined honey, mixing, is prepared into the pill of every ball 4g.
Experimental example 1 applies the clinical observation on the therapeutic effect test of traditional Chinese medicine composition for treating furuncle and phyma of the present invention
One, physical data:
630 routine patients all meet the diagnostic criteria of furuncle and phyma, and patient is divided into 7 groups at random, often organize 90 examples; 7 groups of no significant differences on sex, age, the course of disease and coincident with severity degree of condition.Diagnostic criteria: red, swollen, the little scleroma of pain appears in (1) local, increases gradually thereupon, the pain increased, forms pus and swell after a few days; (2) without obvious General Symptoms; (3) facial furuncle is large with (danger triangle of face) danger around lip, nose, and antibacterial can enter blood along lymphatic vessel and vasoganglion, causes serious intracranial infection.
Two, medicine preparation
Chinese medicine composition 1, takes each crude drug according to following weight: Herba Hydrocotyles 75g, Herba Centellae 75g, Herba Rostellulariae 65g, Herba Oxalidis Corniculatae 65g, Rhizoma Polygoni Cuspidati 35g, Radix Achyranthis 35g, Herba Melastomatis Dodecandri 15g, Herba Houttuyniae 15g;
Above-mentioned each crude drug is decocted with water secondary, adds the water of 4 times of weight for the first time, decoct 2 hours, second time adds the water of 3 times of weight, decocts 1.5 hours; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 DEG C); Add appropriate refined honey, mixing, is prepared into the pill of every ball 4g.
Chinese medicine composition 2: add Stigma Maydis 65g, Herba Duchesneae Indicae 35g, Herba Senecionis Scandentis 15g on Chinese medicine composition 1 basis;
Chinese medicine composition 3: add Radix Glycyrrhizae 65g, Herba Dendranthematis indici 35g, Rhizoma Coptidis 15g on Chinese medicine composition 1 basis;
Chinese medicine composition 4: add Radix Et Rhizoma Rhei 65g, Radix Rehmanniae 35g, Herba Violae 15g on Chinese medicine composition 1 basis;
Chinese medicine composition 5: add Herba Taraxaci 65g, Cortex Phellodendri 35g, Radix Angelicae Dahuricae 15g on Chinese medicine composition 1 basis;
Chinese medicine composition 6: add Radix Saposhnikoviae 65g, Radix Scutellariae 35g, Radix Paeoniae Rubra 15g on Chinese medicine composition 1 basis;
Chinese medicine composition 7: add Flos Lonicerae 65g, Herba Plantaginis 35g, Herba Hedyotidis Diffusae 15g on Chinese medicine composition 1 basis;
The preparation method of Chinese medicine composition 2-7 is with Chinese medicine composition 1.
Three, Therapeutic Method
Treat above-mentioned 7 groups of furuncle and phyma patients with the pill of above-mentioned Chinese medicine composition 1-7 respectively, each patient all follows up a case by regular visits to 1 year; Oral, 2 ball (0.4g crude drug/ball), 2 times on the one, sooner or later respectively once, treats 10 days; Period in a medicine withdraws other related drugs and other treatment.
Four, efficacy assessment standard
Cure: furuncle and phyma transference cure;
Effective: furuncle and phyma symptom is clearly better;
Invalid: furuncle and phyma symptom is not improved, even increase the weight of.
Effective percentage: [(curing number of cases+effectively number of cases)/total case load] × 100%.
Five, clinical observation result
Clinical observation result is in table 1.
The statistical result of the different traditional Chinese medicine composition for treating furuncle and phyma of table 1
Result shows, the Chinese medicine composition prepared by Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae 1 pair of furuncle and phyma has certain therapeutic effect, and effective percentage reaches 71.1%.On Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae basis, add Stigma Maydis, Herba Duchesneae Indicae, Herba Senecionis Scandentis, the effective percentage for the treatment of furuncle and phyma is significantly improved, reaches 97.8%.
These results suggest that, between Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae and Stigma Maydis, Herba Duchesneae Indicae, Herba Senecionis Scandentis, there is significant synergistic function, its compatibility can be significantly improved the effective percentage for the treatment of furuncle and phyma together.By contrast, after Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae are together with other several drugs compatibility, not obvious for the effect improving furuncle and phyma therapeutic effect.Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
The model case of test example 2 traditional Chinese medicine composition for treating furuncle and phyma
Case 1: Yin so-and-so, female, 25 years old, facial many places are long furuncle and phyma, had individually the symptoms such as redness, scorching hot and pain, inside had pustule.Take the pharmaceutical composition prepared by the embodiment of the present invention, three times on the one, once two balls, after the course for the treatment of, pustule diminishes, and scorching hot and pain obviously alleviates, and after taking again a course for the treatment of, cures.
Case 2: Liao, man, 45 years old, back is long furuncle and phyma, red and swollen, there is yellow-white purulent core in the central authorities of redness scleroma, press and be pressed with pain, take the medicine prepared by the embodiment of the present invention 6, three times on the one, once two balls, after 7 days, symptom is eliminated, and a course for the treatment of of after treatment, has no recurrence after following up a case by regular visits to 1 year.
Case 3: Zhao, man, 48 years old, oxter is long had furuncle and phyma, pruritus, pain, and furuncle and phyma scleroma place has pus head, fully recovers, follow up a case by regular visits to after 9 months and have no recurrence after taking 2 courses for the treatment of of medicine prepared by the embodiment of the present invention 6.

Claims (10)

1. treat a Chinese medicine composition for furuncle and phyma, it is characterized in that, comprise following crude drug: Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri and Herba Houttuyniae.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each crude drug is: Herba Hydrocotyles 70-80 part, Herba Centellae 70-80 part, Herba Rostellulariae 60-70 part, Herba Oxalidis Corniculatae 60-70 part, Rhizoma Polygoni Cuspidati 30-40 part, Radix Achyranthis 30-40 part, Herba Melastomatis Dodecandri 10-20 part, Herba Houttuyniae 10-20 part.
3. according to Chinese medicine composition according to claim 2, it is characterized in that, the weight portion of each crude drug is: Herba Hydrocotyles 75 parts, Herba Centellae 75 parts, Herba Rostellulariae 65 parts, Herba Oxalidis Corniculatae 65 parts, Rhizoma Polygoni Cuspidati 35 parts, Radix Achyranthis 35 parts, Herba Melastomatis Dodecandri 15 parts, Herba Houttuyniae 15 parts.
4. treat a Chinese medicine composition for furuncle and phyma, it is characterized in that, comprise following crude drug: Herba Hydrocotyles, Herba Centellae, Herba Rostellulariae, Herba Oxalidis Corniculatae, Rhizoma Polygoni Cuspidati, Radix Achyranthis, Herba Melastomatis Dodecandri, Herba Houttuyniae, Stigma Maydis, Herba Duchesneae Indicae and Herba Senecionis Scandentis.
5. according to Chinese medicine composition according to claim 4, it is characterized in that, the weight portion of each crude drug is: Herba Hydrocotyles 70-80 part, Herba Centellae 70-80 part, Herba Rostellulariae 60-70 part, Herba Oxalidis Corniculatae 60-70 part, Stigma Maydis 60-70 part, Herba Duchesneae Indicae 30-40 part, Rhizoma Polygoni Cuspidati 30-40 part, Radix Achyranthis 30-40 part, Herba Melastomatis Dodecandri 10-20 part, Herba Houttuyniae 10-20 part, Herba Senecionis Scandentis 10-20 part.
6. according to Chinese medicine composition according to claim 5, it is characterized in that, the weight portion of each crude drug is: Herba Hydrocotyles 75 parts, Herba Centellae 75 parts, Herba Rostellulariae 65 parts, Herba Oxalidis Corniculatae 65 parts, Stigma Maydis 65 parts, Herba Duchesneae Indicae 35 parts, Rhizoma Polygoni Cuspidati 35 parts, Radix Achyranthis 35 parts, Herba Melastomatis Dodecandri 15 parts, Herba Houttuyniae 15 parts, Herba Senecionis Scandentis 15 parts.
7. according to the Chinese medicine composition of claim 1 to 6 described in any one, it is characterized in that, be prepared into suitable clinical preparation according to Chinese medicine conventional formulation method, be preferably oral formulations.
8. according to Chinese medicine composition according to claim 7, it is characterized in that, described oral formulations comprises pill, powder, granule, capsule, tablet, oral liquid or drop pill.
9. prepare a method for claim 1 to 6 Chinese medicine composition described in any one, it is characterized in that, comprise the following steps: take each crude drug; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
10. the purposes of the Chinese medicine composition of claim 1 to 6 described in any one in the medicine of preparation treatment furuncle and phyma.
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824082A (en) * 2005-12-28 2006-08-30 天津中天制药有限公司 Jindilan detoxin medicinal composition, preparation and its preparation method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824082A (en) * 2005-12-28 2006-08-30 天津中天制药有限公司 Jindilan detoxin medicinal composition, preparation and its preparation method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANA MARÍA ARNÁIZ-GARCÍA ET AL.: "Management of furuncle, furunculosis and anthrax", 《MEDICINA CLINICA》 *

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