CN104958490A - Medicine for treating qi stagnation and blood stasis type coronary heart diseases and method for manufacturing medicine - Google Patents
Medicine for treating qi stagnation and blood stasis type coronary heart diseases and method for manufacturing medicine Download PDFInfo
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Abstract
The invention discloses medicine for treating qi stagnation and blood stasis type coronary heart diseases and a method for manufacturing the medicine. The medicine comprises 250-300g of roses, 220-260g of bitter oranges, 220-260g of cyperus rotundus, 220-260g of ligusticum wallichii, 160-200g of Chinese thorowax roots, 350-380g of cortex albiziae, 220-260g of white peony roots, 260-320g of salvia miltiorrhiza, 130-180g of panax pseudoginseng, 180-220g of safflowers, 300-350g of rhizome of rehmannia, 160-200g of root-bark of tree peony, 230-280g of angelica sinensis and 180-220g of licorice. The medicine and the method have the advantages that accurate treatment effects can be realized by the medicine for treating the qi stagnation and blood stasis type coronary heart diseases, pain can be quickly relieved, the medicine is long in action time and high in cure rate, and recurrence can be prevented; the medicine is free of medicine resistance and is novel medicine for treating the qi stagnation and blood stasis type coronary heart diseases at present, and antibiotics can be saved.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound and preparation method thereof, particularly relate to and a kind ofly treat medicine of qi stagnation and blood stasis type coronary heart disease and preparation method thereof.
Background technology
Coronary heart disease is the heart disease of a kind of myocardial ischemia-anoxemia (angina pectoris) of being caused by coronary artery organic (atherosclerosis or dynamic property vasospasm) stenosis or occlusion or myocardial necrosis (myocardial infarction), also known as ischemic heart desease.Coronary heart disease is the frequently-occurring disease of serious harm human health, belong to the category of " thoracic obstruction ", the cause of disease has blood stasis, cold coagulation, stagnation of phlegm, the stagnation of QI not, qi depression to blood stasis is one of common disease type of coronary heart disease, risk factor is because patient's spirit is long-term nervous or depressed, or angry excellent think of makes the liver silt stagnation of QI, heart arteries and veins stasis blocking, cause qi depression to blood stasis, heart arteries and veins spasm contracture and occur the symptoms such as chest pain is uncomfortable in chest.We are through the continuous exploration of more than two decades, dialectical treatment primary disease have accumulated abundant clinical experience, the present invention treats qi stagnation and blood stasis type coronary heart disease, and to have cure rate high, side effect is little, the not easily advantage of recurrence, and not producing drug resistance, is the important development direction for the treatment of qi stagnation and blood stasis type coronary heart disease now.
Summary of the invention
The technical problem that the present invention solves is: provide a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease, not only cure rate is high for this Drug therapy qi stagnation and blood stasis type coronary heart disease, and side effect is little, not easily recurs, but also does not produce drug resistance; Another technical problem that the present invention solves is to provide the preparation method of this medicine.
Technical scheme of the present invention is: a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease, it is characterized in that, its crude drug consists of: Flos Rosae Rugosae 250-300 gram, Fructus Aurantii 220-260 gram, Rhizoma Cyperi 220-260 gram, Rhizoma Chuanxiong 220-260 gram, Radix Bupleuri 160-200 gram, Cortex Albiziae 350-380 gram, Radix Paeoniae Alba 220-260 gram, Radix Salviae Miltiorrhizae 260-320 gram, Radix Notoginseng 130-180 gram, Flos Carthami 180-220 gram, Radix Rehmanniae 300-350 gram, Cortex Moutan 160-200 gram, Radix Angelicae Sinensis 230-280 gram, Radix Glycyrrhizae 180-220 gram.
The preferred technical scheme of the present invention is: a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease, it is characterized in that, its crude drug consists of: Flos Rosae Rugosae 280 grams, Fructus Aurantii 240 grams, Rhizoma Cyperi 240 grams, Rhizoma Chuanxiong 240 grams, Radix Bupleuri 190 grams, Cortex Albiziae 360 grams, the Radix Paeoniae Alba 240 grams, Radix Salviae Miltiorrhizae 300 grams, Radix Notoginseng 150 grams, 200 grams, Flos Carthami, 320 grams, the Radix Rehmanniae, Cortex Moutan 190 grams, Radix Angelicae Sinensis 250 grams, 200 grams, Radix Glycyrrhizae.
The present invention further preferred technical scheme is: a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease, is characterized in that, its crude drug composition also comprises: the Radix Aucklandiae 120 grams, Lignum Dalbergiae Odoriferae 210 grams, 230 grams, Lignum Santali Albi, Radix Puerariae 260 grams.
Described a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease, is characterized in that: described medicine can be made as oral liquid.
The preparation method of described oral liquid is:
A, to take Flos Rosae Rugosae respectively according to described crude drug composition, Fructus Aurantii, Rhizoma Cyperi, Rhizoma Chuanxiong, Radix Bupleuri, Cortex Albiziae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Carthami, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Radix Glycyrrhizae are for subsequent use;
B, Flos Rosae Rugosae step A taken, Rhizoma Chuanxiong, Fructus Aurantii, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Carthami add water and did not have powder 2-3cm to soak half an hour, with steam distillation, the medicinal liquid distillation 4h soaked is extracted volatile oil 10-12ml, and the medicament mixed liquid 150-180ml collected after distillation is for subsequent use;
C, Radix Paeoniae Alba step A taken, Rhizoma Cyperi, Cortex Albiziae, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Radix Glycyrrhizae mix with pure water 1:6 volume ratio, and water temperature 30 DEG C is soaked 1 hour, are interrupted and adopt uniform stirrer strand to beat, make medicinal liquid mix homogeneously; Above-mentioned admixing medical solutions is decocted 2 times under 100KPa pressure, each 2h; Filter the above-mentioned medicinal liquid decocted for 2 times, and the medicinal liquid after filtering above-mentioned 2 times mixes and is concentrated into 850-900ml;
D, the concentrated medicament merging medicament mixed liquid after the distillation of above-mentioned steps B collection and step C prepared obtain admixing medical solutions and precipitate 24 hours, and this admixing medical solutions is concentrated into 950-960ml;
The volatile oil that E, the concentrated admixing medical solutions obtained by step D and step B extract shakes up mixing, and to add pure water to total amount volume be 1000-1050ml;
F, benzoic acid 0.3g slowly added prepared by step e with in the admixing medical solutions of volatile oil, with adding with stirring, coating-dividing sealing, flowing steam sterilization 30min.
Instructions of taking: three times on the oral one, each 20-30 milliliter or follow the doctor's advice.Take period and should avoid pungent irritable food.
One, the effect of each material medicine and mechanism
The present invention is by adopting the forward position means of modern scientific research, theoretical with reference to herbal pharmacology research with differential diagnosis in tcm, both the dialectical system of principle-method-recipe-medicines of the traditional Chinese medical science had strictly been deferred to, emphasize again based on the etiology and pathology of doctor trained in Western medicine, in conjunction with Chinese medicine active chemical, according to herbal pharmacology, drug effect and pharmacokinetics basis further investigated Chinese traditional treatment rule.Inventor thinks: qi stagnation and blood stasis type coronary heart disease is basic pathogenesis is deficiency in origin and excess in superficiality, stagnation of QI due to depression of the liver, deficiency of heart-QI.Qi depression to blood stasis is its outstanding symptom.The motive has and promotes blood operation and keep venation unimpeded popular effect, deficiency of heart-QI, can the hyperamization stasis of blood, and cause QI and blood smooth, venation hinders again and is pain uncomfortable in chest, cardiopalmus etc.For the pathogenesis of qi stagnation and blood stasis type coronary heart disease, the present invention establishes soothing the liver promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dredge the meridian passage primary treatments, takes into account other pathological factors.The Chinese medicine that the present invention selects can soothing the liver, promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, and blood vessel dilating, improves microcirculation, anticoagulant, antiplatelet aggregation, promotes thrombolytic, blood fat reducing; Atherosclerosis, antioxidant radical, protection hypoxic-ischemic cardiac muscle, increases cardiopalmus nutrient flow amount.
Flos Rosae Rugosae: sweet and slightly bitter taste, warm in nature.Effect: resolving depression of regulating the flow of vital energy, promoting blood circulation to remove blood stasis, menstruction regulating and pain relieving.
Fructus Aurantii: bitter, pungent, is slightly cold.Effect: regulating the flow of QI to ease the stomach, relieving distension by promoting circulation of QI.
Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, tri-jiao channel.Effect: depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving.
Rhizoma Chuanxiong: pungent, warm.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Bupleuri: bitter, pungent, be slightly cold.Return liver, gallbladder meridian.Effect: induce sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Cortex Albiziae: sweet, flat.Effect: resolving stagnation for tranquilization, promoting blood circulation and detumescence.
The Radix Paeoniae Alba: bitter, acid, to be slightly cold.Return liver, spleen channel.Effect: nourish blood yin fluid astringing, easing the affected liver to relieve pain, suppressing liver-YANG.
Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold.GUIXIN, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.
Radix Notoginseng: sweet, the micro-hardship of property, temperature.Return liver, stomach warp.Effect: dissipating blood stasis stops blooding, subduing swelling and relieving pain.
Flos Carthami: nature and flavor are pungent, temperature.Enter the heart, Liver Channel.Effect: stimulate the menstrual flow, invigorate blood circulation.
The Radix Rehmanniae: nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.
Cortex Moutan: cold in nature, bitter in the mouth; Cool; Be slightly cold.GUIXIN; Liver; Kidney; Lung meridian.Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.
Radix Angelicae Sinensis: sweet, pungent, warm.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.
Radix Glycyrrhizae: sweet in the mouth, gas is put down, and property is delayed.Enter spleen of Foot-Taiyin, the stomach channel of foot-Yang-ming.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.Promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.
Lignum Dalbergiae Odoriferae: pungent, temperature.Enter the heart, Liver Channel.Effect: clots absorbing, hemostasis, analgesic therapy.
Lignum Santali Albi: smoked salubrious dense alcohol, enters liver, spleen, lung three warp.Effect: can regulating QI and delicate fragrance, and effects such as wind is avoided evil spirits, benifit is healthy of fall apart, often smoke useful health.
Radix Puerariae: induce sweat and bring down a fever, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Effect: by improving myocardial ischemia, cardiovascular disease such as control coronary heart diseases and angina pectoris, myocardial infarction etc.
As mentioned above, the principle pathological mechanism of qi stagnation and blood stasis type coronary heart disease is deficiency in origin and excess in superficiality, stagnation of QI due to depression of the liver, deficiency of heart-QI.Flos Rosae Rugosae, Radix Salviae Miltiorrhizae as monarch drug of the present invention, Flos Rosae Rugosae, turbid clearly and not, and and not violent, easing the affected liver is waken up stomach, and thin gas is invigorated blood circulation, and a surname is logical stops up stagnant and absolutely not pungent temperature is just dry fraud, is promoting flow of QI and blood, the key medicine of Shugan Zhitong, Radix Salviae Miltiorrhizae bitter in the mouth is slightly cold, promoting blood circulation, removing blood stasis and relieving pain and the non-impairment of QI-blood.Modern pharmacology confirms: Radix Salviae Miltiorrhizae can scavenging activated oxygen; Protective wire plastochondria, improves energy metabolism; Alleviate calcium overload, stablize myocardial cell membrane, improve myocardial ischemia and reperfusion injury, coronary artery dilating, increase Doppler flow mapping open, increase myocardial nutrition blood volume, allevating angina pectoris; Flos Rosae Rugosae obtain its promoting flow of QI and blood of Radix Salviae Miltiorrhizae, Shugan Zhitong, dredge the meridian passage effect larger, Flos Rosae Rugosae and Radix Salviae Miltiorrhizae this be mutual restraint between two drugs mutual reinforcement between also; Radix Bupleuri, Fructus Aurantii, Rhizoma Cyperi help effect of Flos Rosae Rugosae, Radix Salviae Miltiorrhizae depressed liver-energy dispersing and QI regulating, dredge the meridian passage, are ministerial drug.Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder is positive clearly, with Fructus Aurantii compatibility, the power work especially of eliminating stagnation of regulating the flow of vital energy; Radix Bupleuri, Rhizoma Cyperi, harmonizing the functional activities of vital QI, resolving depression of regulating the flow of vital energy, has the wonderful of promoting flow of QI and blood, can alleviate the anxiety of various muscular tone, particularly smooth muscle, and promotes the normal creepage of gastrointestinal functions of smooth muscle and beat, thus improves arterial vascular function; Flos Rosae Rugosae, Radix Salviae Miltiorrhizae obtain Radix Bupleuri, Fructus Aurantii, its promoting flow of QI and blood of Rhizoma Cyperi, Shugan Zhitong, improve myocardial ischemia, increase myocardial nutrition blood volume, effect of allevating angina pectoris is larger; Radix Angelicae Sinensis, the circulation of qi promoting of Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, Rhizoma Chuanxiong is the gas medicine in blood, has the merit of blood circulation promoting and blood stasis dispelling, and Rhizoma Chuanxiong can improve microcirculation, reduces blood viscosity stickiness, makes blood drag reduction, be conducive to improving blood supply of cardiac muscle, have calcium channel blocking action; Radix Angelicae Sinensis is invigorated blood circulation and is had blood stasis dispelling and non-blood trouble wonderful, and Radix Angelicae Sinensis, Rhizoma Chuanxiong help Radix Bupleuri, Fructus Aurantii, Rhizoma Cyperi to strengthen effect of its depressed liver-energy dispersing and QI regulating further altogether; Radix Notoginseng, Flos Carthami help Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling, and Flos Carthami can improve microcirculation, strengthens ischemic area blood flow, reduces blood viscosity, promote thromboembolism, Radix Notoginseng can allevating angina pectoris effectively, increases heart coronary artery blood flow, decreased heart rate, increases myocardial contraction; The Radix Paeoniae Alba has suppressing the hyperactive liver relieving spasm to stop pain, promoting blood circulation, disappear the effects such as blood stasis, can also blood circulation promoting and blood stasis dispelling, antiplatelet aggregation, suppress coronary spasm, increase coronary flow, improve the effects such as the oxygen-resistant ability of cardiac muscle, there is beta receptor retardation, Radix Notoginseng, Flos Carthami, the Radix Paeoniae Alba and Radix Bupleuri, Fructus Aurantii, Rhizoma Cyperi share the harmonizing the functional activities of vital QI strengthening Radix Bupleuri, Fructus Aurantii, Rhizoma Cyperi further, the effect of resolving depression of regulating the flow of vital energy; The Radix Rehmanniae, Cortex Moutan cooling blood and removing stasis, assist a ruler in governing a country the monarch and his subjects and strengthen blood stasis dispelling effect, with the adjuvant drug of the Radix Paeoniae Alba as we, assists monarch drug to play the merit of its promoting flow of QI and blood; The function that Cortex Albiziae has resolving depression, calms the nerves, invigorates blood circulation, makes medicine as we; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, simultaneously tonifying QI to promote blood circulation, monarch compatibility pressed by all medicines, jointly plays blood-activating and qi-promoting, effect of stasis-dispelling and pain-killing.
Intestinal stasis relieving in Radix Aucklandiae promoting the circulation of QI to relieve pain, tune; The pungent loose temperature of Lignum Dalbergiae Odoriferae is led to, enter Liver Channel, walk blood system and the merit of the clots absorbing hemostasis analgesic therapy that declines, has; The regulating QI of Lignum Santali Albi energy and delicate fragrance, and effects such as wind is avoided evil spirits, benifit is healthy of faling apart; Radix Puerariae, by improving myocardial ischemia, prevents and treats the cardiovascular disease such as coronary heart diseases and angina pectoris, myocardial infarction.Effect that the Radix Aucklandiae, Lignum Dalbergiae Odoriferae, Lignum Santali Albi, Radix Puerariae help monarch drug Flos Rosae Rugosae of the present invention altogether, Radix Salviae Miltiorrhizae improves its thin gas blood circulation promoting and blood stasis dispelling, coronary artery dilating, promoting the circulation of QI to relieve pain.
Two, observation of curative effect method of the present invention
1, observation of curative effect: for determining the curative effect of this medicine, carries out clinical research according to " the coronary heart disease differential diagnosis in tcm test standard " that " name of ischemic heart desease and diagnostic criteria " and the whole nation of World Health Organization's regulation are formulated.Select 200 routine qi stagnation and blood stasis type patients with coronary heart disease, be divided into treatment group and matched group by randomization.Treatment group 120 example, takes medicine oral liquid of the present invention, a 20ml, 3 times on the one; Matched group 80 example, takes FUFANG DANSHEN PIAN one time 4,3 times on the one.Two groups of state of an illness, the course of disease, without significant difference, have comparability (P > 0.05).Within one month, be a course for the treatment of, per course for the treatment of, interval 3-5 days, observed 2 courses for the treatment of, checked electrocardiogram, triglyceride, cholesterol, Chest X-rays, hepatic and renal function, recorded heart rate, blood glucose, untoward reaction etc. before observing.Criterion of therapeutical effect: cure: electrocardiogram, heart rate are normal; Effective: electrocardiogram takes a turn for the better, and heart rate is tending towards normal; Effective: the state of an illness does not develop; Invalid: the state of an illness continues development.Total effective rate=cure rate+obvious effective rate+effective percentage.
2, therapeutic outcome:
Comparitive study after two groups 2 courses for the treatment of
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 120 | 41 | 47 | 21 | 11 | 90.83％ |
| Matched group | 80 | 15 | 19 | 13 | 33 | 58.75％ |
Two groups in cure rate, obvious effective rate, effective percentage, total effective rate, all there were significant differences, and P<0.05, has comparability.
Find in clinical observation, before and after treatment group treatment, blood fat, hepatic and renal function make moderate progress, and blood glucose etc. are without significant change, and stomach discomfort 2 is routine; After treatment of control group, blood glucose raises 4 examples, and cholesterol, triglyceride, low density lipoprotein, LDL are without significant change, and renal function increases 2 examples, nauseating, thirsty 3 examples; After drug withdrawal, 2 weeks above-mentioned symptoms disappear.
Know from experience: apply 2 courses for the treatment of of Drug therapy of the present invention, total effective rate is 90.83%, and matched group is only 58.75%; Two groups of untoward reaction are compared, and medicine of the present invention makes moderate progress to blood fat, hepatic and renal function etc., and untoward reaction in various degree has then appearred in matched group, and affects renal function, blood glucose.Therefore, Drug therapy qi stagnation and blood stasis type coronary heart disease of the present invention can be drawn, there is efficient, safety, feature without obvious adverse reaction.
Three, medical record citing;
1, patient Zhang, male, 79 years old, December in 2005 first visit on the 30th.Patient, because of precordialgia repeatedly 3 years, increases the weight of to seek medical advice for 1 month.Patient often because precordialgia appears in fatigue, showed effect weekly 1 ~ 2 time, can alleviate after buccal nitroglycerin over 3 years.Because of movable tired over nearly 1 month, precordialgia increases the weight of, and shows effect weekly 6 ~ 8 times, companion's cardiopalmus, weak, uncomfortable in chest, tachypnea, dreaminess, is hard and dry.Previously: outmoded inferior wall myocardial infarction.Usually oral glad health, visit aspirin for treatment.Tongue is dark red, and tongue is white, deep and stringy pulse, blood pressure 120/70mmHg, heart rate 89 beats/min, EKG: sinus rhythm, accidental room early, outmoded lower wall heart infarction.Give oral liquid every day 3 times that the present invention makes, each 20ml, decoction being taken warmly 1 month was 1 course for the treatment of; Per course for the treatment of 3 ~ 5 days, interval, take further consultation after 2 courses for the treatment of continuously, angina pectoris attack times obviously reduces, and shows effect weekly 1 ~ 2 time, persistent period reduced to 2 ~ 4 seconds by 10 seconds, still felt weak, slightly felt cardiopalmus, and the dark red tongue of tongue is white, deep pulse, no more side effects, then after taking 1 course for the treatment of, all cards are alleviated.Follow up a case by regular visits to 6 months, the state of an illness is steady, has no recurrence.
2, patient Zhang, man, 56 years old, October 12 was admitted to hospital because of stabbing pain over the chest, the 3h that feels oppressed.Patient has History of Coronary Heart Disease 3 years. and often because tired and emotional factors bring out, stabbing pain over the chest or vexed pain, alleviate after generally continuing the medicine such as 5 ~ 10min or oral SUXIAO JIUXIN WAN.Nearly October does not freely cause episode 4 times, in twinge because of feelings will. and angor or vexed pain, after taking SUXIAO JIUXIN WAN, 5 ~ 10min can be alleviated.Though this time outbreak is alleviated because must not continue without medicine at one's side. take SUXIAO JIUXIN WAN symptom afterwards and alleviate also not obvious, therefore be admitted to hospital in the hope for the treatment of.Disease is seen: stabbing pain over the chest, chest distress, sighing frequently, shortness of breath and palpitation. coerce and swollenly not relax. and irritated, anorexia, insomnia and dreamful sleep, tongue is dark red ecchymosis, yellow and thin fur, stringy pulse knot generation.BP150/110mmHgEKG shows: T ripple II, III, aVF, V
5-6be inverted .ST section V
3-6move down 0.12mV, visible roomy lopsided QRS ripple.Western medicine diagnose: angina pectoris, forelock ventricular premature contraction tcm diagnosis: obstruction of qi in the chest and cardialgia (qi depression to blood stasis, blockage of the cardiac vessels type).Control with dispersing the stagnated liver-QI and dredging collateral, promoting blood circulation and stopping pain.Give oral liquid every day 3 times that the present invention makes, each 2Oml, decoction being taken warmly, within 1 month, be a course for the treatment of, per course for the treatment of 3 ~ 5 days, interval, chest pain after taking 1 course for the treatment of, breast are felt oppressed improvement, shortness of breath and palpitation, coerce the disease such as swollen and alleviate, dysphoria, insomnia, dreaminess improve not obvious.Stable disease more than continuing to serve on 2 courses for the treatment of.December check electrocardiogram on the 6th is roughly normal, and patient can normally work.Follow up a case by regular visits to three months without recurrence.
3, grandson patient so-and-so, women, 65 years old, office worker.First visit: on November 16th, 2014.Main suit because of conscious cardiopalmus uncomfortable in chest, more obvious after activity, occasionally have precordialgia and go to a doctor.Wall myocardial infarction is asked before patient happens suddenly July.Take the medicines such as simvastatin (SHUJIANGZHI), enteric coated aspirin, Isosorbide-5-Mononitrate, atenolol (atenolol) at present.Inscribe electrocardio diagram: ST II, sT III, STv5 force down, and R IV is greater than Rv2,3, T IV-5 is inverted, and Tv6 is low flat.Patient's xerostomia, bitter taste, kind sigh, conscious distension and fullness in the abdomen, belch is done frequently, and defecate partially dry, purplish tongue, tongue fur purple secretly has petechia, stringy and rolling pulse.The rhythm of the heart is neat, and two lung is clear, and abdomen is soft, and liver spleen is little, two lower limb pneumonedema.Tcm diagnosis: the thoracic obstruction (qi stagnation and blood stasis type); Western medicine diagnose: acute front partition myocardial infarction convalescent period.The rule for the treatment of: vital energy regualting and blood circulation-promoting, clearing away heat-damp and promoting diuresis.Give oral liquid every day 3 times that the present invention makes, each 20ml, decoction being taken warmly 1 month was 1 course for the treatment of, per course for the treatment of 3 ~ 5 days, interval, after taking 2 courses for the treatment of continuously, stool every day 2 times, xerostomia, bitter taste alleviate, and sometimes have borborygmus, and abdominal distention comparatively before alleviates, and do not have angina pectoris attacks.Cardiopalmus, symptom uncomfortable in chest are also conscious to be alleviated.Dark tongue quality, yellow fur is slightly greasy, deep-rolling pulse.Heart rate 74/min, rule is neat, and two lung is clear.ECG ST
iI, S
iII, S
iVforce down comparatively and improve, R
v2,3amplitude slightly increases.After continuing 3 courses for the treatment of of oral liquid that oral the present invention makes, after Flos Rosae Rugosae Shuxin Oral, cardiopalmus, symptom disease uncomfortable in chest subtract, without angina pectoris attacks.Conscious abdominal distention obviously alleviates, free movement of the bowels, dark tongue quality, and tongue is closely normal, deep-rolling pulse.Heart rate 74/min, rule is neat.
Beneficial effect of the present invention is: pharmacology of the present invention is that all medicines share to have and improve microcirculation, coronary artery dilator, increase coronary flow, improve myocardial oxygen delivery amount, improve hemodynamics, reduce whole blood viscosity and erythrocyte and platelet aggregation, reduction fibrinogen level, reduce the effect such as wall of vein leukocyte and blood fat reducing, thus improve human bloodstream power, microcirculation, metabolism and immunologic function etc., also Human Umbilical Vein Endothelial Cells and ischemic myocardium can play certain protective effect; There is alleviating pain fast, drug treating time is long, patient compliance is good, the feature that side effect is little, obviously can improve the clinical symptoms of patients with coronary heart disease, also be improved blood fat, there is good therapeutic effect, can embody that ancient prescription is applied flexibly, the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the Synergistic treatment that can play again modern Chinese medicine pharmacology, the effect heightened the effect of a treatment, can be used as the routine administration for the treatment of qi stagnation and blood stasis type coronary heart disease; Drug therapy qi stagnation and blood stasis type coronary heart disease instant effect of the present invention, cure rate is high, not easily recurs, and does not also produce drug resistance, saves antibiotic, is conducive to the application of Chinese medicine in clinical, is a kind of newtype drug for the treatment of qi stagnation and blood stasis type thoracic obstruction outbreak at present.
Detailed description of the invention
The specific embodiment of the invention is:
Embodiment 1,
A, take Flos Rosae Rugosae 250 grams, Fructus Aurantii 220 grams, Rhizoma Cyperi 260 grams, Rhizoma Chuanxiong 260 grams, Radix Bupleuri 200 grams, Cortex Albiziae 350 grams, the Radix Paeoniae Alba 260 grams, Radix Salviae Miltiorrhizae 320 grams, Radix Notoginseng 130 grams, 220 grams, Flos Carthami, 350 grams, the Radix Rehmanniae, Cortex Moutan 200 grams, Radix Angelicae Sinensis 230 grams, 220 grams, Radix Glycyrrhizae, the Radix Aucklandiae 120 grams, Radix Puerariae 260 grams are for subsequent use;
B, Flos Rosae Rugosae step A taken according to prescription, Rhizoma Chuanxiong, Fructus Aurantii, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Carthami add water and did not have powder 2-3cm to soak half an hour, with steam distillation, the medicinal liquid distillation 4h soaked is extracted volatile oil 10ml, and the medicament mixed liquid 160ml collected after distillation is for subsequent use;
C, Radix Paeoniae Alba step A taken according to prescription, Rhizoma Cyperi, Cortex Albiziae, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Radix Glycyrrhizae, the Radix Aucklandiae, Radix Puerariae mix with pure water 1:6 volume ratio, and water temperature 30 DEG C is soaked 1 hour, are interrupted and adopt uniform stirrer strand to beat, make medicinal liquid mix homogeneously; Above-mentioned admixing medical solutions is decocted 2 times under 100KPa pressure, each 2h; Filter the above-mentioned medicinal liquid decocted for 2 times, and the medicinal liquid after filtering above-mentioned 2 times mixes and is concentrated into 870ml;
D, the concentrated medicament merging medicament mixed liquid after the distillation of above-mentioned steps B collection and step C prepared obtain admixing medical solutions and precipitate 24 hours, and this admixing medical solutions is concentrated into 960ml;
The volatile oil that E, the concentrated admixing medical solutions obtained by step D and step B extract shakes up mixing, and to add pure water to total amount volume be 1020ml;
F, 0.3 gram, benzoic acid slowly added prepared by step e with in the admixing medical solutions of volatile oil, with adding with stirring, coating-dividing sealing, flowing steam sterilization 30min.
Embodiment 2
A, take Flos Rosae Rugosae 280 grams, Fructus Aurantii 240 grams, Rhizoma Cyperi 240 grams, Rhizoma Chuanxiong 240 grams, Radix Bupleuri 190 grams, Cortex Albiziae 360 grams, the Radix Paeoniae Alba 240 grams, Radix Salviae Miltiorrhizae 300 grams, Radix Notoginseng 150 grams, 200 grams, Flos Carthami, 320 grams, the Radix Rehmanniae, Cortex Moutan 190 grams, Radix Angelicae Sinensis 250 grams, 200 grams, Radix Glycyrrhizae are for subsequent use;
B, Flos Rosae Rugosae step A taken according to prescription, Rhizoma Chuanxiong, Fructus Aurantii, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Carthami add water and did not have powder 2-3cm to soak half an hour, with steam distillation, the medicinal liquid distillation 4h soaked is extracted volatile oil 11ml, and the medicament mixed liquid 150ml collected after distillation is for subsequent use;
C, Radix Paeoniae Alba step A taken according to prescription, Rhizoma Cyperi, Cortex Albiziae, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Radix Glycyrrhizae mix with pure water 1:6 volume ratio, and water temperature 30 DEG C is soaked 1 hour, are interrupted and adopt uniform stirrer strand to beat, make medicinal liquid mix homogeneously; Above-mentioned admixing medical solutions is decocted 2 times under 100KPa pressure, each 2h; Filter the above-mentioned medicinal liquid decocted for 2 times, and the medicinal liquid after filtering above-mentioned 2 times mixes and is concentrated into 850ml;
D, the concentrated medicament merging medicament mixed liquid after the distillation of above-mentioned steps B collection and step C prepared obtain admixing medical solutions and precipitate 24 hours, and this admixing medical solutions is concentrated into 950ml;
The volatile oil that E, the concentrated admixing medical solutions obtained by step D and step B extract shakes up mixing, and to add pure water to total amount volume be 1000ml;
F, 0.3 gram, benzoic acid slowly added prepared by step e with in the admixing medical solutions of volatile oil, with adding with stirring, coating-dividing sealing, flowing steam sterilization 30min.
Embodiment 3
A, take Flos Rosae Rugosae 300 grams, Fructus Aurantii 260 grams, Rhizoma Cyperi 220 grams, Rhizoma Chuanxiong 220 grams, Radix Bupleuri 160 grams, Cortex Albiziae 380 grams, the Radix Paeoniae Alba 220 grams, Radix Salviae Miltiorrhizae 260 grams, Radix Notoginseng 180 grams, 180 grams, Flos Carthami, 300 grams, the Radix Rehmanniae, Cortex Moutan 160 grams, Radix Angelicae Sinensis 280 grams, 180 grams, Radix Glycyrrhizae, the Radix Aucklandiae 120 grams, Lignum Dalbergiae Odoriferae 210 grams, 230 grams, Lignum Santali Albi, Radix Puerariae 260 grams are for subsequent use;
B, Flos Rosae Rugosae step A taken according to prescription, Rhizoma Chuanxiong, Fructus Aurantii, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Carthami add water and did not have powder 2-3cm to soak half an hour, with steam distillation, the medicinal liquid distillation 4h soaked is extracted volatile oil 12ml, and the medicament mixed liquid 180ml collected after distillation is for subsequent use;
C, Radix Paeoniae Alba step A taken according to prescription, Rhizoma Cyperi, Cortex Albiziae, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Radix Glycyrrhizae, the Radix Aucklandiae, Lignum Dalbergiae Odoriferae, Lignum Santali Albi, Radix Puerariae mix with pure water 1:6 volume ratio, water temperature 30 DEG C is soaked 1 hour, be interrupted and adopt uniform stirrer strand to beat, make medicinal liquid mix homogeneously; Above-mentioned admixing medical solutions is decocted 2 times under 100KPa pressure, each 2h; Filter the above-mentioned medicinal liquid decocted for 2 times, and the medicinal liquid after filtering above-mentioned 2 times mixes and is concentrated into 900ml;
D, the concentrated medicament merging medicament mixed liquid after the distillation of above-mentioned steps B collection and step C prepared obtain admixing medical solutions and precipitate 24 hours, and this admixing medical solutions is concentrated into 960ml;
The volatile oil that E, the concentrated admixing medical solutions obtained by step D and step B extract shakes up mixing, and to add pure water to total amount volume be 1050ml;
F, 0.3 gram, benzoic acid slowly added in admixing medical solutions prepared by step e, with adding with stirring, coating-dividing sealing, flowing steam sterilization 30min.
Claims (5)
1. treat the medicine of qi stagnation and blood stasis type coronary heart disease for one kind, it is characterized in that, its crude drug consists of: Flos Rosae Rugosae 250-300 gram, Fructus Aurantii 220-260 gram, Rhizoma Cyperi 220-260 gram, Rhizoma Chuanxiong 220-260 gram, Radix Bupleuri 160-200 gram, Cortex Albiziae 350-380 gram, Radix Paeoniae Alba 220-260 gram, Radix Salviae Miltiorrhizae 260-320 gram, Radix Notoginseng 130-180 gram, Flos Carthami 180-220 gram, Radix Rehmanniae 300-350 gram, Cortex Moutan 160-200 gram, Radix Angelicae Sinensis 230-280 gram, Radix Glycyrrhizae 180-220 gram.
2. a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease according to claim 1, it is characterized in that, its crude drug consists of: Flos Rosae Rugosae 280 grams, Fructus Aurantii 240 grams, Rhizoma Cyperi 240 grams, Rhizoma Chuanxiong 240 grams, Radix Bupleuri 190 grams, Cortex Albiziae 360 grams, the Radix Paeoniae Alba 240 grams, Radix Salviae Miltiorrhizae 300 grams, Radix Notoginseng 150 grams, 200 grams, Flos Carthami, 320 grams, the Radix Rehmanniae, Cortex Moutan 190 grams, Radix Angelicae Sinensis 250 grams, 200 grams, Radix Glycyrrhizae.
3. a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease according to claim 2, is characterized in that, its crude drug composition also comprises: the Radix Aucklandiae 120 grams, Lignum Dalbergiae Odoriferae 210 grams, 230 grams, Lignum Santali Albi, Radix Puerariae 260 grams.
4. a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease according to any one of claims 1 to 3, is characterized in that: described medicine can be made as oral liquid.
5. a kind of preparation method for the treatment of the medicine of qi stagnation and blood stasis type coronary heart disease as claimed in claim 4, is characterized in that: described oral liquor comprises the steps:
A, to take Flos Rosae Rugosae respectively according to described crude drug composition, Fructus Aurantii, Rhizoma Cyperi, Rhizoma Chuanxiong, Radix Bupleuri, Cortex Albiziae, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Carthami, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Radix Glycyrrhizae are for subsequent use;
B, Flos Rosae Rugosae step A taken, Rhizoma Chuanxiong, Fructus Aurantii, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Notoginseng, Flos Carthami add water and did not have powder 2-3cm to soak half an hour, with steam distillation, the medicinal liquid distillation 4h soaked is extracted volatile oil 10-12ml, and the medicament mixed liquid 150-180ml collected after distillation is for subsequent use;
C, Radix Paeoniae Alba step A taken, Rhizoma Cyperi, Cortex Albiziae, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Radix Glycyrrhizae mix with pure water 1:6 volume ratio, and water temperature 30 DEG C is soaked 1 hour, are interrupted and adopt uniform stirrer strand to beat, make medicinal liquid mix homogeneously; Above-mentioned admixing medical solutions is decocted 2 times under 100KPa pressure, each 2h; Filter the above-mentioned medicinal liquid decocted for 2 times, and the medicinal liquid after filtering above-mentioned 2 times mixes and is concentrated into 850-900ml;
D, the concentrated medicament merging medicament mixed liquid after the distillation of above-mentioned steps B collection and step C prepared obtain admixing medical solutions and precipitate 24 hours, and this admixing medical solutions is concentrated into 950-960ml;
The volatile oil that E, the concentrated admixing medical solutions obtained by step D and step B extract shakes up mixing, and to add pure water to total amount volume be 1000-1050ml;
F, 0.3 gram, benzoic acid slowly added prepared by step e with in the admixing medical solutions of volatile oil, with adding with stirring, coating-dividing sealing, flowing steam sterilization 30min.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687713A (en) * | 2016-03-22 | 2016-06-22 | 青岛市中心医院 | Traditional Chinese medicine preparation for treating coronary heart disease |
| CN106038943A (en) * | 2016-05-07 | 2016-10-26 | 姜秀芹 | A traditional Chinese medicine for treating heart blood stagnation type thoracic obstruction |
| CN107375600A (en) * | 2017-07-17 | 2017-11-24 | 上海市静安区中医医院 | A kind of Chinese medicine composition for treating qi stagnation and blood stasis type coronary heart disease and its application |
| CN108014243A (en) * | 2017-12-26 | 2018-05-11 | 慈中华 | For nursing one's health the Chinese herbal ointment formula and its processing method of blood stasis constitution |
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| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN103784820A (en) * | 2014-02-23 | 2014-05-14 | 曹小松 | Traditional Chinese medicine formula for treating cariac blood stasis type coronary heart disease |
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| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687713A (en) * | 2016-03-22 | 2016-06-22 | 青岛市中心医院 | Traditional Chinese medicine preparation for treating coronary heart disease |
| CN106038943A (en) * | 2016-05-07 | 2016-10-26 | 姜秀芹 | A traditional Chinese medicine for treating heart blood stagnation type thoracic obstruction |
| CN107375600A (en) * | 2017-07-17 | 2017-11-24 | 上海市静安区中医医院 | A kind of Chinese medicine composition for treating qi stagnation and blood stasis type coronary heart disease and its application |
| CN108014243A (en) * | 2017-12-26 | 2018-05-11 | 慈中华 | For nursing one's health the Chinese herbal ointment formula and its processing method of blood stasis constitution |
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