CN100382834C - Traditional Chinese medicine for treating coronary heart disease and angina pectoris - Google Patents

Abstract

A Chinese medicine for treating coronary heart disease and angina pectoris is prepared from 11 Chinese-medicinal materials including leech, red peony root, Chuan-xiong rhizome, astragalus root, etc.

Description

A kind of Chinese medicine for the treatment of angina pectoris

Technical field:

The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine for the treatment of angina pectoris.

Background technology:

Modern western medicine thinks that the pathogeny of angina pectoris is to conflict between the need blood of blood supply coronarius and cardiac muscle, coronary artery blood flow can not satisfy the needs of myocardial metabolism, when causing rapid, the temporary transient hypoxic-ischemic of cardiac muscle, promptly produce angina pectoris.

Western medical treatment one is to use nitroglycerin (glyceryl trinitrate) class expansion coronary vasodilator, but it makes most patient pay effect to the poison that expansion artery produced of this type of medicine: as pollex severe headache, giddy, dizzy, even postural hypotension appears, simultaneously, also can make ophthalmic vasodilation and increase intraocular pressure, cause glaucomatous generation etc. to bear or to accept, influenced therapeutic effect, and recurrence easily; The 2nd, modern doctor trained in Western medicine Vasculocardiology Deparment adopts the coronarography inspection and inserts stent in the treatment, and it costs an arm and a leg again and waits deficiency, is more unsuitablely accepted by patient and family members.

Angina pectoris is common cardiovascular diseases, is more common in the middle-aged and elderly people more than 50 years old, the people of this age bracket, and social pressure is big, and family burden is heavy, and work rhythm is fast, the old people's that work position is changeful and the age is bigger again " empty nest treatment ".Make the emotion variation abnormality of some middle-aged and elderly people, cause the arterial vascular tensity of body to strengthen, arteries attenuates, and tube chamber narrows down, and the hurried minimizing of blood flow causes the frequent generation of angina pectoris, and very person's myocardial infarction that occurs together causes sudden death.

Angina pectoris belongs to the traditional Chinese medical science " thoracic obstruction " " pained " category.Its pathogenesis mostly is deficiency in origin and excess in superficiality.According to middle-aged and elderly people the five internal organs deficiency and coldness, deficiency of both vital energy and Yin and emotion cause stagnation of QI due to depression of the liver unusually, qi depression to blood stasis, and blood stasis is obstructed, and the principle of stagnation of QI and blood may bring about pain thinks that the primary disease deficiency in origin is based on deficiency of both QI and YIN, and mark is seen with the resistance of the heart arteries and veins stasis of blood actually.Add abnormal emotion-thought, primary disease is increased the weight of.Therefore, clinical treatment is when holding up it with supplementing QI and nourishing YIN, and blood circulation promoting and blood stasis dispelling is promoted blood circulation and controlled its mark, throws soothing liver-QI for relieving depression again, and the chest stuffiness relieving is regulated the flow of vital energy, and the capable then blood of gas is capable, the capable then beniol of blood, the then pained spontaneous recovery of beniol.

Summary of the invention:

The objective of the invention is to adopt theory of Chinese medical science, hold up it with supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling is promoted blood circulation and is controlled its mark, throws the Chinese medicine of the treatment angina pectoris of soothing liver-QI for relieving depression again.

The present invention makes the raw materials of effective components weight portion and consists of:

Hirudo 5～15 Radix Paeoniae Rubra 15～30 Rhizoma Chuanxiongs 15～25 Radixs Astragali 25～45

Radix Ophiopogonis 10～20 Semen Persicaes, 10～25 Flos Carthamis, 10～25 Radix Angelicae Sinensis 10～35

Pheretima 10～30 Radix Bupleuri 10～25 Fructus Trichosanthis 10～40

The present invention makes the raw materials of effective components weight portion and consists of:

Hirudo 5 Radix Paeoniae Rubra 15 Rhizoma Chuanxiongs 15 Radixs Astragali 25

Radix Ophiopogonis 10 Semen Persicaes, 10 Flos Carthamis, 10 Radix Angelicae Sinensis 10

Pheretima 10 Radix Bupleuri 10 Fructus Trichosanthis 10

Advantage of the present invention is:

1, the present invention prepares simply, and cheap, curative effect is reliable, and treatment time is short, should not recur, and does not more have the poison that resembles Western medicine (nitrate esters) and pays effect.Social benefit is good, and economic benefit is splendid.

2, increase the heartbeat output, cardiac output improves cardiac index, strengthens cardiac pumping function, improves ventricular diastole function and arterial compliance, coronary artery dilator, coronary blood flow increasing.

3, the present invention reduces myocardial oxygen consumption, improves myocardial hypoxia tolerance.

4, the present invention reduces whole blood viscosity, plasma viscosity, and packed cell volume improves the blood samples of patients viscosity, and control coronary vasodilator microcirculation " Gao Ning " state and microthrombusis improve coronary artery circulation, increase blood supply of cardiac muscle.

5, the present invention can effectively reduce anginal attack times and shorten the angina pectoris attacks time, has avoided the generation of myocardial infarction, has stopped the sudden death that angina pectoris causes, and does not see untoward reaction.

The specific embodiment:

The present invention makes the raw materials of effective components weight portion and consists of:

Hirudo 5～15 Radix Paeoniae Rubra 15～30 Rhizoma Chuanxiongs 15～25 Radixs Astragali 25～45

Radix Ophiopogonis 10～20 Semen Persicaes, 10～25 Flos Carthamis, 10～25 Radix Angelicae Sinensis 10～35

Pheretima 10～30 Radix Bupleuri 10～25 Fructus Trichosanthis 10～40

Manufacture method is:

At first will go up medicinal cold water 1000ml, soak 30 minutes, after the reuse big fire is boiled 30 minutes, use slow fire boiling instead, decoct medicinal herbs liquid is surplus to be 200ml, uses health gauze (three layers) filtering liquid medicine, and then repeats once by last method, to obtain herb liquid is placed on for twice in one glass, divide two parts, every part of 200ml, every day secondary, each 200ml, one after each meal (heating back).

Embodiment 1:

Hirudo 5 Radix Paeoniae Rubra 15 Rhizoma Chuanxiongs 15 Radixs Astragali 25

Radix Ophiopogonis 10 Semen Persicaes, 10 Flos Carthamis, 10 Radix Angelicae Sinensis 10

Pheretima 10 Radix Bupleuri 10 Fructus Trichosanthis 10

Method is the same.

Embodiment 2:

Hirudo 10 Radix Paeoniae Rubra 22.5 Rhizoma Chuanxiongs 20 Radixs Astragali 35

Radix Ophiopogonis 15 Semen Persicaes, 17.5 Flos Carthamis, 17.5 Radix Angelicae Sinensis 22.5

Pheretima 200 Radix Bupleuri 17.5 Fructus Trichosanthis 25

Method is the same.

Embodiment 3:

Hirudo 15 Radix Paeoniae Rubra 30 Rhizoma Chuanxiongs 25 Radixs Astragali 45

Radix Ophiopogonis 20 Semen Persicaes, 25 Flos Carthamis, 25 Radix Angelicae Sinensis 35

Pheretima 30 Radix Bupleuri 25 Fructus Trichosanthis 40

Method is the same.

Hirudo of the present invention, Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Radix Astragali, Radix Ophiopogonis are monarch drug, and Semen Persicae, Flos Carthami are ministerial drug, and Radix Angelicae Sinensis, Pheretima are adjuvant drug, and Radix Bupleuri, Fructus Trichosanthis are messenger drug.

The Radix Astragali of the present invention, Radix Ophiopogonis, benefit motive YIN nourishing and the production of body fluid promoting was controlled its deficiency in origin, compatibility Hirudo, Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubra blood circulation promoting and blood stasis dispelling, and it is real to control its mark, the Fructus Trichosanthis the chest stuffiness relieving of regulating the flow of vital energy, compatibility Radix Bupleuri liver-smoothing, qi-regulating, Pheretima has the effect of collateral dredging, diuresis, antianginal.

Modern pharmacological research shows that the Radix Astragali can reduce heart rate, reduces cardiac energy consumption, can strengthen myocardial contraction Radix Ophiopogonis, increases heart throughput rate and coronary flow, and Hirudo has the coronary vasodilator of releasing smooth muscle spasm, reduce crown resistance, increase coronary flow, allevating angina pectoris.Rhizoma Chuanxiong has the external thrombus of inhibition and forms, and reduces myocardial oxygen consumption, and anticoagulant is alleviated angina pectoris, reduces coronary resistance, and Flos Carthami, Semen Persicae can improve hemorheological property and myocardium microcirculation, improve myocardial flow.Fructus Trichosanthis can improve cardiac muscle to anoxybiotic tolerance.Radix Bupleuri has dispersing the stagnated live-QI to relieve the stagnation of QI, and general rule is not bitterly.

Clinical data of the present invention:

Selection is diagnosed as angina pectoris patient 62 examples, is divided into two groups at random.Treatment group (of the present invention group) 32 examples, male 19 examples, women 13 examples, 50～74 years old age, average 61.43 ± 5.31 years old, course of disease half a year～17 year, average 8.61 ± 3.36 years old.Wherein concurrent acute myocardial infarction 14 examples are implemented coronal artery angiography and insert the support person's 8 examples.Matched group (Composite Salvia Dropping Pill group), 30 examples, man's 18 examples, woman's 12 examples, 49～75 years old age, average 59.38 ± 5.64 years old, the course of disease 5 months～16.5, average 7.46 ± 3.65 years, there is not significant difference (P＞0.05) at aspects such as sex, age, the courses of disease before two groups of case treatments, have comparability.

Diagnostic criteria:

All cases meet national heart disease association and WHO clinical name standardization associating special topic is organized the anginal diagnostic criteria of coronary heart disease stable type fatigue in " ischemic heart desease name and the diagnostic criteria " reported.And to belong to differential diagnosis in tcm be deficiency of both QI and YIN, heart arteries and veins blood stasis blocking type, and angina pectoris attacks is more than 2～3 times weekly, and " the clinical research guideline of the new Chinese medicine treatment thoracic obstruction (angina pectoris) " that differential diagnosis in tcm is formulated with reference to Ministry of Public Health formulates following differential diagnosis in tcm standard:

A, uncomfortable in chest, chest paroxysm twinge or dull pain, localized pain, companion's cardiopalmus;

B, breathe hard or deficiency of QI with disinclination to talk;

C, sweating while acting;

D or pharyngoxerosis;

E or constipation with dry stool;

F, pale tongue are dark or purple dark, few tongue;

G, thready and hesitant pulse or tensioning or the knot generation.

Therapeutic Method:

Treatment group (of the present invention group) is made up of Hirudo, Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Radix Astragali, Radix Ophiopogonis, Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Pheretima, Radix Bupleuri, Fructus Trichosanthis, 200ml/ bag, a twice-daily, each 200ml.Be a course of treatment all around.

Matched group (Composite Salvia Dropping Pill group) is made up of Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum, and Tianjin Tasly Pharmaceutical Co., Ltd produces, authentication code: the accurate word Z10950111 of traditional Chinese medicines, and usage every day 3 times, each 10 balls, 4 weeks were a course of treatment.

Therapeutic outcome:

" angina pectoris and the ECG curative effect evaluation criteria " that criterion of therapeutical effect angina pectoris and ECG curative effect are drafted with reference to national combination of Chinese and Western medicine forum in 1979;

Concrete therapeutic outcome sees Table 1:

Table 1 liang group curative effect to treat angina pectoris relatively

Annotate: compare P＜0.05 with matched group

Last table is as seen: the treatment group is alleviated the angina pectoris obvious effective rate and total effective rate all obviously is better than matched group, and significant difference (P＜0.05) is arranged.

Claims (2)

1. Chinese medicine for the treatment of angina pectoris, wherein make the raw materials of effective components weight portion and consist of:

Hirudo 5～15 Radix Paeoniae Rubra 15～30 Rhizoma Chuanxiongs 15～25 Radixs Astragali 25～45

Radix Ophiopogonis 10～20 Semen Persicaes, 10～25 Flos Carthamis, 10～25 Radix Angelicae Sinensis 10～35

Pheretima 10～30 Radix Bupleuri 10～25 Fructus Trichosanthis 10～40

2. the Chinese medicine of treatment angina pectoris according to claim 1, wherein make the raw materials of effective components weight portion and consist of:

Hirudo 5 Radix Paeoniae Rubra 15 Rhizoma Chuanxiongs 15 Radixs Astragali 25

Radix Ophiopogonis 10 Semen Persicaes, 10 Flos Carthamis, 10 Radix Angelicae Sinensis 10

Pheretima 10 Radix Bupleuri 10 Fructus Trichosanthis 10