CN100333750C - Traditional Chinese medicine preparation for treating thoracic obstruction and palpitation and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating thoracic obstruction and palpitation and preparation method thereof Download PDFInfo
- Publication number
- CN100333750C CN100333750C CNB2005100733427A CN200510073342A CN100333750C CN 100333750 C CN100333750 C CN 100333750C CN B2005100733427 A CNB2005100733427 A CN B2005100733427A CN 200510073342 A CN200510073342 A CN 200510073342A CN 100333750 C CN100333750 C CN 100333750C
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- thoracic obstruction
- medicine
- paeoniae rubra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 37
- 210000000115 thoracic cavity Anatomy 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 206010033557 Palpitations Diseases 0.000 title abstract description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 17
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 17
- 235000008434 ginseng Nutrition 0.000 claims abstract description 17
- 229930182490 saponin Natural products 0.000 claims abstract description 11
- 235000017709 saponins Nutrition 0.000 claims abstract description 11
- 150000007949 saponins Chemical class 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 238000011282 treatment Methods 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 239000000843 powder Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 241000208340 Araliaceae Species 0.000 claims description 16
- 239000009636 Huang Qi Substances 0.000 claims description 16
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 9
- -1 reflux Substances 0.000 claims description 7
- 241000545442 Radix Species 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 229930182494 ginsenoside Natural products 0.000 claims description 6
- 229940089161 ginsenoside Drugs 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 60
- 238000012360 testing method Methods 0.000 abstract description 44
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- 241001061264 Astragalus Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 208000031971 Yin Deficiency Diseases 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 231100000041 toxicology testing Toxicity 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 description 32
- 239000008280 blood Substances 0.000 description 27
- 206010047470 viral myocarditis Diseases 0.000 description 26
- 210000004369 blood Anatomy 0.000 description 23
- 230000001737 promoting effect Effects 0.000 description 16
- 208000024891 symptom Diseases 0.000 description 16
- 230000007812 deficiency Effects 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 11
- 208000009525 Myocarditis Diseases 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 230000001154 acute effect Effects 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 230000001914 calming effect Effects 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 230000001684 chronic effect Effects 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000002107 myocardial effect Effects 0.000 description 6
- 210000004165 myocardium Anatomy 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 208000008454 Hyperhidrosis Diseases 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 5
- 210000000038 chest Anatomy 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 206010003119 arrhythmia Diseases 0.000 description 4
- 230000006793 arrhythmia Effects 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 208000029078 coronary artery disease Diseases 0.000 description 4
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 4
- 229960003444 immunosuppressant agent Drugs 0.000 description 4
- 230000001861 immunosuppressant effect Effects 0.000 description 4
- 239000003018 immunosuppressive agent Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 206010008479 Chest Pain Diseases 0.000 description 3
- 206010019280 Heart failures Diseases 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000001524 infective effect Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 208000031225 myocardial ischemia Diseases 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- OPFTUNCRGUEPRZ-QLFBSQMISA-N (-)-beta-elemene Chemical compound CC(=C)[C@@H]1CC[C@@](C)(C=C)[C@H](C(C)=C)C1 OPFTUNCRGUEPRZ-QLFBSQMISA-N 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 206010016807 Fluid retention Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 2
- 239000000006 Nitroglycerin Substances 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 239000003470 adrenal cortex hormone Substances 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000000916 dilatatory effect Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 229960003711 glyceryl trinitrate Drugs 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000001308 heart ventricle Anatomy 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229940079322 interferon Drugs 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 210000000607 neurosecretory system Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000003119 painkilling effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 238000002636 symptomatic treatment Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- OPFTUNCRGUEPRZ-UHFFFAOYSA-N (+)-beta-Elemen Natural products CC(=C)C1CCC(C)(C=C)C(C(C)=C)C1 OPFTUNCRGUEPRZ-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 description 1
- 108010054479 3',5'-Cyclic-AMP Phosphodiesterases Proteins 0.000 description 1
- 102000001707 3',5'-Cyclic-AMP Phosphodiesterases Human genes 0.000 description 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010003211 Arteriosclerosis coronary artery Diseases 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 206010064539 Autoimmune myocarditis Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 206010007191 Capillary fragility Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008469 Chest discomfort Diseases 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 206010009866 Cold sweat Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010056370 Congestive cardiomyopathy Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 201000010046 Dilated cardiomyopathy Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 108050009340 Endothelin Proteins 0.000 description 1
- 102000002045 Endothelin Human genes 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- VDWSYBFEQXWINA-UHFFFAOYSA-N Martinoside Natural products C1=C(O)C(OC)=CC=C1CCOC1C(O)C(OC2C(C(O)C(O)C(C)O2)O)C(OC(=O)C=CC=2C=C(O)C(OC)=CC=2)C(CO)O1 VDWSYBFEQXWINA-UHFFFAOYSA-N 0.000 description 1
- KJHOZAZQWVKILO-UHFFFAOYSA-N N-(diaminomethylidene)-4-morpholinecarboximidamide Chemical compound NC(N)=NC(=N)N1CCOCC1 KJHOZAZQWVKILO-UHFFFAOYSA-N 0.000 description 1
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 206010066901 Treatment failure Diseases 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 208000033774 Ventricular Remodeling Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- WLWAYPFRKDSFCL-CNMJWYMJSA-N [(2r,3r,4r,5r,6r)-5-hydroxy-6-[2-(3-hydroxy-4-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate Chemical compound C1=C(O)C(OC)=CC=C1CCO[C@H]1[C@H](O)[C@@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@H](OC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)[C@@H](CO)O1 WLWAYPFRKDSFCL-CNMJWYMJSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000000489 anti-atherogenic effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 210000004618 arterial endothelial cell Anatomy 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000739 chaotic effect Effects 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- RLGRBYHBNWLGER-UHFFFAOYSA-N cistanoside D Natural products C1=C(O)C(OC)=CC(CCOC2C(C(OC3C(C(O)C(O)C(C)O3)O)C(OC(=O)C=CC=3C=C(OC)C(O)=CC=3)C(CO)O2)O)=C1 RLGRBYHBNWLGER-UHFFFAOYSA-N 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007887 coronary angioplasty Methods 0.000 description 1
- 208000026758 coronary atherosclerosis Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000002001 electrophysiology Methods 0.000 description 1
- 230000007831 electrophysiology Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002461 excitatory amino acid Effects 0.000 description 1
- 239000003257 excitatory amino acid Substances 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000010247 heart contraction Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 230000001709 ictal effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- ZMYQRHSOVRDQDL-NSWBACJASA-N leucosceptoside A Natural products COc1cc(C=CC(=O)O[C@@H]2[C@@H](CO)O[C@@H](OCCc3ccc(O)c(O)c3)[C@H](O)[C@H]2O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)ccc1O ZMYQRHSOVRDQDL-NSWBACJASA-N 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 150000005692 lignans Chemical class 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- WLWAYPFRKDSFCL-AYPSUWEUSA-N martynoside Natural products COc1ccc(CCO[C@@H]2O[C@H](CO)[C@@H](OC(=O)C=Cc3ccc(O)c(OC)c3)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@H]2O)cc1O WLWAYPFRKDSFCL-AYPSUWEUSA-N 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 229960005389 moroxydine Drugs 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 208000023482 precordial pain Diseases 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000006318 protein oxidation Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 244000132619 red sage Species 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicament for treating thoracic obstruction and palpitation and a preparation method thereof, the preparation is prepared by carefully selecting and composing the components of astragalus, rehmannia, schisandra, salvia, red paeony root, cassia twig and ginseng stem leaf total saponins, the effects of the medicaments generate synergistic action by combining the medicaments, and aiming at the causes of thoracic obstruction and palpitation, the invention develops rich clinical experience of traditional Chinese medicine, combines with modern pharmacological research and carries out a large number of tests. Clinical tests, toxicological studies and pharmacodynamical studies prove that the traditional Chinese medicine composition has obvious curative effects on qi and yin deficiency type thoracic obstruction and palpitation.
Description
Technical field
The invention discloses a kind of medicine and preparation method for the treatment of the thoracic obstruction, cardiopalmus, is feedstock production with Chinese medicine specifically, belongs to the field of Chinese medicines.
Background technology
The disease of the thoracic obstruction, cardiopalmus category has coronary heart disease (coronary atherosclerotic heart disease), angina pectoris (angina pectoris coronary heart disease), arrhythmia, myocarditis etc.Coronary heart disease, anginal major lesions are the narrow myocardial ischemia that causes of coronary atherosclerosis, can cause myocardial infarction, finally cause heart failure.The cardiac electrophysiology disorder that arrhythmia then causes for multiple reason.Myocarditis mostly is the viral infection cardiac muscle and causes various clinical symptoms.The relative incidence rate of viral myocarditis constantly increases in recent years.State of an illness weight difference, show widely different, much heavier the infant state of an illness is, and much lighter the adult is, and the lighter can not have obvious condition of illness, weight person can concurrent severe arrhythmia, cardiac insufficiency even sudden death, patient can have heating, tired, hyperhidrosis, nervous, out of breath, uncomfortable in chest, pareordia dull pain, dizziness and weak etc., often accompany increased heart rate or slow down, fluctuation of blood pressure, anxious, pale complexion or cold sweat, weight person can have out of breath, dyspnea, even shock etc.Angina pectoris is a kind of caused by the temporary transient ischemia of cardiac muscle, anoxia, serves as the clinical syndrome of main performance with ictal chest pain or chest discomfort.The unstable angina pectoris patient has 8%～16% myocardial infarction and cardiac sudden death take place approximately.Myocarditis, angina pectoris are equivalent to traditional Chinese medical science obstruction of qi in the chest and cardialgia, angina pectoris, precordial pain with cold limbs, cardiopalmus disease, and cardiopalmus is the palpitation uneasiness, a kind of conscious disease that very then can not be autonomous, popular name " heart beating ".Many and the Nervous and Mental Factors of the formation of cardiopalmus, deficiency of heart-blood, declination of heart-YANG, fluid-retention stagnating in the interior, congestion resistance networks etc. are relevant, and the branch of deficiency and excess is arranged more, and empty person is with timidness due to deficiency of the heart, and it is main that blood failing to tonify the heart, hyperactivity of fire caused by deficiency of YIN, deficiency of heart-YANG decline etc.Reality person ties mutually with phlegm-fire, and pathogenic fluid-retention is insulted the heart, and stasis of blood resistance heart arteries and veins etc. is main.Assertive evidence is seen so that deficiency complicated with excess person more.Chest pain and doublely see cough with asthma, abundant expectoration, the fever of the body person belongs to due to the expectorant heat more.If painful area is fixed, twinge person, belong to qi depression to blood stasis more.If the painful shoulder back of the body that connects, doublely feel oppressed, even the cold extremities due to sweating person, belong to the thoracic obstruction more.Getting to the bottom of sb.'s illness, many genus cardiopulmonary are weakened body resistance to be this, with qi depression to blood stasis, and the resistance of YIN-cold numbness, phlegm-heat obstructing in the lung is for marking.The dialectical card that belongs to deficiency in origin and excess in superficiality more.
The treatment of the thoracic obstruction, cardiopalmus is comparatively chaotic and a controversial difficult problem always, and people attempted many Therapeutic Method, even to this day, lies up, anti symptom treatment and support still be main treatment means.Doctor trained in Western medicine is mainly used treatments such as blood vessel dilating class, immunosuppressant class, corticosteroid hormone class, analgesic to the thoracic obstruction, cardiopalmus, and immunosuppressant because it has suppressed the antiviral immunity reaction, easily causes the viral infection diffusion.Immunosuppressant is useful to autoimmune myocarditis in theory, but differentiate in the clinical practice that myocarditis is the viral very difficulty of autoimmunity that still has, the clinical trial of using immunosuppressant therapy myocarditis/dilated cardiomyopathy fails to draw definite results so far.Though corticosteroid hormone class, blood vessel dilating class, analgesic etc. can reach the effect of controlling symptoms, because toxic and side effects is big, treatment cycle is long, makes the patient fear and is difficult to accept.After the medical treatment failure, cardiac catheter intervention and surgical operation (percutaneous tranluminal coronary angioplasty) expand to attack by air bag narrow tube chamber are increased, and success rate is lower, and the expense height, and is painful big, narrow application range, and postoperative may be left over sequela.Though Chinese traditional treatment myocarditis and anginal medicine are a lot, only the patent of invention of China's application just reach 190 surplus, application number is 91102313.5, a kind of manufacture method of Chinese medicine Zhixindan; 200410069139.8, card-otonic heart protecting pill; 200410004907.1, a kind of extraction for the treatment of cardiovascular disease and concentrate the pure Chinese medicinal preparation that combines, but or do not have compellent clinical data and model case, curative effect makes us doubting, or lacking pharmacodynamic experiment data and safety research, toxicity is unknown.Traditional therapy is also nothing more than attacking the pathogens first and then tonifying or tonifying first and then eliminating the pathogen, pain relieving by force, and symptomatic treatment in acute condition, rules such as relieving the primary symptom in a chronic case, that tests is clinical, though certain curative effect is arranged, controlling symptoms is produced effects slowly, is difficult to tackle the problem at its root.
Summary of the invention
Purpose of the present invention is exactly the problem that exists at above-mentioned prior art, need not perform the operation and provide a kind of, has vital energy benefiting and the kidney invigorating, clearing away heat and cooling blood, air making-up and spleen enlivening, the multiple arteries and veins that promotes the production of body fluid, the mind calming and mentality promoting, blood circulation promoting and blood stasis dispelling, mind tranquilizing and the heart calming, eliminating stasis to stop pain, supporing yang activating QI, promoting the flow of QI-blood by warming the meridian, Yin-heart nurishing, simultaneous elimination and reinforcement, the cold mutual aid of temperature, treating both the principal and secondary aspects of a disease, be applicable to various myocarditis, anginal treatment, and the high Chinese medicine preparation of cure rate.
This preparation be famous pharmacologist professor ZhaoDongKe based on motherland's medical science to the thoracic obstruction, the pathogenetic understanding of cardiopalmus, theory of Chinese medical science thinks that the treatment thoracic obstruction, cardiopalmus works as symptomatic treatment in acute condition, based on eliminating evil, makes general rule not bitterly, is important method of treatment with blood circulation promoting and blood stasis dispelling wherein.Treat heresy unsting subtract after, QI invigorating again is with Pei Qiben.If deficiency complicated with excess when also through-supplementation, just can reach strengthening vital QI to eliminate pathogenic factors, replenishing QI to invigorate the spleen, nourishing yin and promoting blood circulation, the purpose that nourishes blood and allay excitement.The inventor excavates the traditional Chinese medical science and enriches clinical experience, in conjunction with modern pharmacological research, tests drawing in a large number, and each amounts of components all has better curative effect in the following weight parts scope.
Radix Astragali 55-65 part, Radix Rehmanniae 30-40 part, Fructus Schisandrae Chinensis 15-22 part, Radix Salviae Miltiorrhizae 15-22 part, Radix Paeoniae Rubra 30-40 part, Ramulus Cinnamomi 15-22 part, stem and leaf of Radix Ginseng total saponins 0.5-1.5 part.
Be preferably: 60 parts of the Radixs Astragali, 36 parts of Radix Rehmanniae, 18 parts of Fructus Schisandrae Chinensis, 18 parts of Radix Salviae Miltiorrhizaes, 36 parts of Radix Paeoniae Rubra, 18 parts of Ramulus Cinnamomi, 1 part of stem and leaf of Radix Ginseng total saponins.
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Has invigorating QI to consolidate the body surface resistance, diuresis poison holding, vital energy benefiting and the kidney invigorating, expelling pus and promoting granulation effect; Radix Rehmanniae: sweet in the mouth, hardship, cold in nature.GUIXIN, liver, lung meridian.Have clearing away heat and cooling blood, the YIN nourishing of enriching blood, vital essence replenishing and marrow benifiting, YIN nourishing and the production of body fluid promoting is assisted mutually with the Radix Astragali, and reinforcing both QI and YIN two medicines that bring out the best in each other are monarch's medicine; Fructus Schisandrae Chinensis: sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming, with the Radix Astragali, Radix Rehmanniae compatibility, both principal drug assistance benefiting qi and nourishing yin main effects of concentrating one's efforts, but spleen invigorating is promoted the production of body fluid again, mind tranquilizing and the heart calming; Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel.The stasis-dispelling and pain-killing relieving restlessness that clears away heart-fire, blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind.Radix Paeoniae Rubra: hardship is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain four medicines are ministerial drug.Ramulus Cinnamomi: hot, sweet, temperature.GUIXIN, lung, urinary bladder channel.The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins is adjuvant drug; Radix Ginseng: sweet in the mouth, little hardship, warm in nature, have regulating QI nourish blood, the calm the nerves effect of Fructus Alpiniae Oxyphyllae, air making-up and spleen enlivening, promote the production of body fluid multiple arteries and veins, the mind calming and mentality promoting, nourishing and fit keeping function, be described as " king of BAICAO ".Mainly contain more than 10 kind of ginsenoside, and the fast alcohol of Radix Ginseng, beta-elemene, saccharide, several amino acids and vitamin etc.
Full side has that invigorating QI to consolidate the body surface resistance, diuresis are astringent or styptic treatment for spontaneous sweating, Fructus Alpiniae Oxyphyllae is nourished blood, calmed the nerves in expelling pus and promoting granulation, clearing away heat and cooling blood, the YIN nourishing of enriching blood, vital essence replenishing and marrow benifiting, convergence dissipating blood stasis, supplementing QI for promoting the production of body fluid, kidney calming, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire, promoting the flow of QI-blood by warming the meridian, blood circulation promoting and blood stasis dispelling, supporing yang activating QI, the flat gas that spins, regulating QI, spleen invigorating is allayed excitement, the effect of nourishing and fit keeping function, strengthening vital QI to eliminate pathogenic factors, through-supplementation, the cold mutual aid of temperature, treating both the principal and secondary aspects of a disease, play benefiting QI for activating blood circulation altogether, the merit of Yin-heart nurishing.
Studies show that through modern pharmacology, the present invention contains chemical constituents such as stem and leaf of Radix Ginseng total saponins, Radix Astragali saponin and polysaccharide, Martynoside. and sugar, Fructus Schisandrae Chinensis volatile oil and lignans composition, cinnamic acid, coumarin, Radix Salviae Miltiorrhizae acid and ketone, peoniflorin, has multiple pharmacological effect.
1, study of anti-atherogenic effect
The content of the many and blood inner cholesterol of atherosclerosis, platelet aggregation, and reason such as coronary artery endothelial damage is relevant.The present invention can be synthetic by reducing aorta wall cholesterol level and cell inner cholesterol, lipotropism matter protein oxidation, and make that lipid peroxide obviously reduces in the oxidation lipoprotein, and the toxic action of oxidation lipoprotein pair cell is weakened, reduce the atherosclerosis area; Suppress the platelet calmodulin, CaM, reduce the activity of phosphodiesterase, cAMP content in the platelet increasing, anticoagulant, reduction fibrinogen content and erythrocyte aggregation index reduce packed cell volume, reduce blood viscosity, prevent the blood vessel wall collagen deposition; Alleviate the damage of fibrin clot to blood vessel endothelium.
2, improve patient's prognosis
For a long time, over-drastic neuroendocrine system activates, then can start the process that apoptosis of cardiac muscle and ventricle are reinvented, and can form a vicious cycle with the latter two, and gradually the heart behind the myocardial ischemia is pushed the abyss of heart failure, have a strong impact on patient's prognosis.
The present invention mainly shows as regulating action to central nervous excitation and inhibition to the influence of maincenter function of nervous system, nervus centralis there is excitation, inhibitory action is arranged again, by strengthening corticocerebral process of excitation, make excitement and process of inhibition be able to balance, make anxiety cause disorderly neural activity to be recovered normally to improve the motility of neural activity process.Reduce cerebral tissue TXA
2Generation, the cerebral tissue excitatory amino acid discharges when suppressing ischemia, to the central nervous system tangible calm function can be arranged.Make endothelin level (ET) level descend (NO) the corresponding raising of level.Stimulate arterial endothelial cell secretion PGI
2Deng the secretion of regulating the heart peptide of living, avoid long-time, over-drastic neuroendocrine system to activate, the generation that stops apoptosis of cardiac muscle and ventricle to be reinvented.
Medicine of the present invention has protective effect to the apoptosis of cardiac muscle that myocardial ischemia reperfusion injury brings out, and also possesses the function that suppresses left ventricular remodeling.
3, arrhythmia
By blocking myocardium β
1Receptor weakens myocardial contraction, decreased heart rate; To the myocardial cell abnormal electrical activity of viral myocarditis, by suppressing Na
+-K
+The activity of-ATP enzyme is regulated the rhythm of the heart.
4, antiviral is to the infective virus myocardial protective effect
Reduce the sensitivity of the myocardial cell of infective virus to virus; Relevant to the infective virus myocardial protective effect with calcium antagonism, can improve the Ca of infection cell
2+Balance, thus the Ca of infection cell alleviated
2+Secondary injury can suppress duplicating of viral nucleic acid in the infection cell again; Strengthen myocardial cell and produce interferon and short inducement interferon effect.
5, to the influence of blood pressure, blood vessel
Blood pressure is had dual regulation, and it regulates the function of vascular smooth muscle cell (VSMC) by the conversion of signals passage of NOsGC, cGMP mediation, thus adjust blood pressure, blood flow and control arteriosclerosis; Microcirculation improvement increases the resistance of blood capillary, prevents the capillary fragility due to the chemical factors and the increase of permeability; The open number of capillary network is increased, promote side to prop up circulation and set up.
Another object of the present invention provides manufacturing method for above mentioned medicine.
Preparation method: the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Ramulus Cinnamomi, the Radix Ginseng seven flavor medicine, get 1/3rd of Radix Paeoniae Rubra recipe quantity earlier and be ground into fine powder, standby, Radix Salviae Miltiorrhizae and residue Radix Paeoniae Rubra add 4.5-5.5 and doubly measure 90%-95% alcohol reflux secondary, each 1.5-2.5 hour, merge the stream extract, filter, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.3-1.4 (60 ℃ of heat is surveyed), vacuum drying, be ground into fine powder, standby, the alcohol extraction medicinal residues and the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Ramulus Cinnamomi, decoct with water three times, for the first time add 8-12 times of water gaging, decocted 1.5-2.5 hour, add 6-10 times of water gaging for the second time, decocted 1.0-2.0 hour, add 5-7 times of water gaging for the third time, decocted 0.5-1.5 hour, merge three times decoction liquor, subtract and be compressed to the thick paste that relative density is 1.3-1.4 (60 ℃ of heat is surveyed), add the Radix Paeoniae Rubra fine powder, stir vacuum drying, be ground into fine powder, standby, ginsenoside's powder and above-mentioned fine powder be mix homogeneously repeatedly, granulates with 90%-95% ethanol 16 mesh sieves, oven dry, 16 mesh sieve granulate are sub-packed in the capsule, sterilization back packing.
This composition of medicine also can be made pill, powder, electuary, unguentum, oral liquid.
In order to verify the good effect of medicine of the present invention, the inventor is in first Affiliated Hospital of Xi'an Communications University, the hospital of traditional Chinese hospital, Shaanxi Province, Xi'an Jiaotong University Medical College's clinical pharmacology institute has carried out a large amount of experiments, now select the part clinical experiment report as follows, all the other clinical trials, toxicologic study, the particulars of pharmacodynamic study is seen appendix.Drug nomenclature of the present invention is ' XINXINSHU JIAONANG '.
The test example
Clinical trial
The XINXINSHU JIAONANG treatment thoracic obstruction, cardiopalmus (myocarditis, angina pectoris) 465 routine clinical trials are summed up
One, physical data
1, patient source: case 465 examples are observed in this test altogether, test group 320 examples (viral myocarditis test group 70 examples, angina pectoris test group 250 examples) wherein, matched group 145 examples (viral myocarditis matched group 35 examples, angina pectoris matched group 110 examples) test group clinic case 122 examples, inpatient's 198 examples, matched group clinic case 50 examples, inpatient's 95 examples.
2, sex: see Table 1.1, table 1.2
Two groups of patient's sexes of table 1.1 viral myocarditis situation relatively
| Group | The example number | The man | The woman |
| Test group | 70 | 32(45.7) | 38(54.3) |
| Matched group | 35 | 11(31.4) | 24(68.6) |
Through check, sex difference nonsignificance (P＞0.05) between two groups of viral myocarditis has comparability.
Two groups of patient's sexes of table 1.2 angina pectoris situation relatively
| Group | The example number | The man | The woman |
| Test group | 250 | 161(64.4) | 89(35.6) |
| Matched group | 110 | 70(63.6) | 40(36.4) |
Through check, sex difference nonsignificance (P＞0.05) between two groups of angina pectoriss has comparability.
3, the age: the oldest 42 years old of viral myocarditis test group, minimum 12 years old, 30.2 years old mean age; Oldest 45 years old of matched group, minimum 13 years old, 29.6 years old mean age.Oldest 65 years old of angina pectoris test group, minimum 31 years old, 56.2 years old mean age; Oldest 65 years old of matched group, minimum 35 years old, 58 years old mean age.See Table 2.1,2.2
Two groups of age distribution comparisons of table 2.1 viral myocarditis (year)
| Group | The example number | 0～ | 15～ | 25～ | 35～45 |
| Test group | 70 | 15(21.4) | 18(25.7) | 12(17.1) | 25(35.8) |
| Matched group | 35 | 8(22.9) | 10(28.6) | 7(20.0) | 17(48.5) |
Two groups of age distribution there was no significant differences of viral myocarditis (p＞0.05) have comparability.
Two groups of age distribution comparisons of table 2.2 angina pectoris (year)
| Group | The example number | 0～ | 35～ | 45～ | 55～65 |
| Test group | 250 | 28(11.2) | 37(14.8) | 85(34.0) | 100(40.0) |
| Matched group | 110 | 8(7.3) | 14(12.7) | 45(40.9) | 43(39.1) |
Two groups of age distribution there was no significant differences of angina pectoris (p＞0.05) have comparability.
4, the course of disease before the treatment sees Table 3.1,3.2
The course of disease compares (year) before two groups of patient of table 3.1 viral myocarditis
| Group | The example number | 0～ | 0.5～ | 1～ |
| Test group | 70 | 18(25.7) | 20(28.6) | 32(45.7) |
| Matched group | 35 | 8(22.9) | 9(25.7) | 18(51.4) |
Course of disease distribution situation there was no significant difference before two groups of treatments of viral myocarditis, (p＞0.05) has comparability.
The course of disease compares (year) before two groups of patient of table 3.2 angina pectoris
| Group | The example number | 0～ | 1～ | 3～ | 5～ | 10～ | Average course of disease |
| Test group | 250 | 79(31.6) | 73(29.2) | 61(24.4) | 21(8.4) | 16(6.4) | 4.2 |
| Matched group | 110 | 31(28.2) | 37(33.6) | 25(22.7) | 12(10.9) | 5(4.6) | 3.8 |
Course of disease distribution situation there was no significant difference (p＞0.05) before two groups of treatments of angina pectoris has comparability.
5, clinical scale, by stages, typing, see,, 4.1,4.2,4.3
The clinical stages comparison of table 4.1 viral myocarditis
| Group | The example number | Acute stage | Convalescent period | Lag phase | Chronic phase |
| Test group | 70 | 18(25.7) | 20(28.6) | 12(17.1) | 20(35.8) |
| Matched group | 35 | 8(22.9) | 10(28.6) | 7(20.0) | 17(48.6) |
Table 4.2 viral myocarditis Clinical typing relatively
| Group | The example number | Light-duty | Medium-sized | Heavy |
| Test group | 70 | 15(21.4) | 18(25.7) | 12(17.1) |
| Matched group | 35 | 8(22.9) | 10(28.6) | 7(20.0) |
Two component phases of viral myocarditis, typing situation there was no significant difference (p＞0.05) have comparability.
Table 4.3 angina pectoris clinical scale relatively
| Group | The example number | Slightly | Moderate | Severe |
| Test group | 250 | 98(39.2) | 116(46.4) | 36(14.4) |
| Matched group | 110 | 45(40.9) | 50(45.5) | 15(13.6) |
Two groups of clinical scale situations of angina pectoris there was no significant difference (p＞0.05) has comparability.
Two, include the case standard in
Tcm diagnosis is the type of deficiency of both QI and YIN thoracic obstruction, cardiopalmus, and Western medicine diagnose is viral myocarditis, angina pectoris.
Three, test method
Adopt single blind completely random grouping, the viral myocarditis test group is taken XINXINSHU JIAONANG, 3 times on the one, one time five; Matched group is taken ubiquinone
10Capsule, 3 times on the one, a 30mg adds VITAMIN C TABLET, moroxydine in case of necessity.Be a course of treatment all around.
The angina pectoris test group is taken XINXINSHU JIAONANG, 3 times on the one, one time five; Matched group is taken GUANXIN DANSHEN PIAN, 3 times on the one, one time three.Be a course of treatment all around.
Four, efficacy determination and foundation: with reference to " XINXINSHU JIAONANG clinical trial protocol "
The viral myocarditis comprehensive therapeutic effect is divided.
Clinical cure: clinical symptoms, sign disappear, and it is normal that electrocardiogram recovers, and sero-enzyme CPK, LDH, AST recover normal.Produce effects: clinical symptoms, sign disappear, and electrocardiogram obviously improves, and sero-enzyme CPK, LDH, AST are near normal.Effectively: clinical symptoms, sign are obviously improved, and the electrocardiogram part is normal, and sero-enzyme CPK, LDH, AST obviously reduce.Invalid; Clinical symptoms, sign, electrocardiogram, sero-enzyme CPK, LDH, AST all do not have improvement.
The viral myocarditis ECG curative effect is divided.
Produce effects: electrocardiogram recovers normally or is roughly normal; Effectively: electrocardiogram obviously improves; Invalid: the electrocardiogram no change.
The angina pectoris comprehensive therapeutic effect is divided: clinic control, produce effects, effective, invalid; ECG curative effect is divided: produce effects, effective, invalid.
Five, result of the test
(1) viral myocarditis efficacy analysis
1, two groups of comprehensive therapeutic effects see Table 5
Table 5 liang group comprehensive therapeutic effect relatively
| Group | The example number | Clinical cure | Produce effects | Effectively | Invalid | Total effective rate | p |
| Test group | 70 | 11(15.7) | 41(58.6) | 15(21.4) | 3(4.3) | 95.7％ | ＜0.01 |
| Matched group | 35 | 2(5.7) | 4(11.4) | 8(22.9) | 21(60.0) | 40.0％ |
As can be seen from Table 5, analyze through Ridit, there were significant differences (p＜0.01) for comprehensive therapeutic effect between two groups, and test group obviously is better than matched group.
2, two groups of ECG curative effect see Table 6
Table 6 ECG curative effect relatively
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate | p |
| Test group | 68 | 19(27.9) | 24(35.3) | 25(36.8) | 63.2％ | ＜0.01 |
| Matched group | 31 | 3(9.7) | 10(32.3) | 18(58.1) | 41.9％ |
As can be seen from Table 6, analyze through Ridit, there were significant differences (p＜0.01) for ECG curative effect between two groups, and test group obviously is better than matched group.
3, two groups of treatment front and back doing well,improving situations see Table 7
Table 7 clinical symptoms is improved situation
| Symptom | The treatment group | Matched group | ||||||||
| The example number | Produce effects | Effectively | Invalid | Total effective rate | The example number | Produce effects | Effectively | Invalid | Total effective rate | |
| Uncomfortable in chest | 68 | 33 | 32 | 3 | 95.6％* | 34 | 8 | 14 | 12 | 64.7％ |
| Cardiopalmus | 60 | 43 | 23 | 3 | 95.7％* | 33 | 9 | 8 | 16 | 51.5％ |
| Breathe hard | 42 | 21 | 1 8 | 2 | 95.2％* | 25 | 8 | 7 | 10 | 60.0％ |
| Weak | 60 | 22 | 34 | 4 | 93.3％* | 31 | 6 | 7 | 18 | 41.9％ |
| Pharyngalgia | 18 | 11 | 5 | 2 | 88.9％* | 8 | 2 | 2 | 4 | 50.0％ |
| Heating | 10 | 6 | 3 | 1 | 90.0％* | 5 | 2 | 1 | 2 | 60.0％ |
There were significant differences (* p＜0.05) for two groups of each symptom curative effects as can be seen from Table 7, and test group obviously is better than matched group.
4, test group curative effect comparison by stages sees Table 8
Table 8 test group curative effect by stages compares
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate |
| Acute stage | 18 | 10(25.7) | 6(28.6) | 2(17.1) | 88.9％ |
| Convalescent period | 20 | 12(22.9) | 6(28.6) | 2(20.0) | 95.0％ |
| Lag phase | 12 | 8(66.7) | 3(25.0) | 1(8.3) | 91.7％ |
| Chronic phase | 20 | 10(50.0) | 8(40.0) | 2(10.0) | 90.0％ |
Test group increased in acute viral myocarditis, convalescent period, lag phase, chronic phase curative effect by analysis, there was no significant difference between the three (p＞0.05).
(2), curative effect to treat angina pectoris
1, two groups of comprehensive therapeutic effects relatively see Table 9
Table 9 liang group comprehensive therapeutic effect relatively
| Group | The example number | Clinic control | Produce effects | Effectively | Invalid | Total effective rate | P |
| Test group | 250 | 78(3 1.2) | 130(52.0) | 25(10.0) | 17(6.8) | 93.2％ | ＜0.01 |
| Matched group | 110 | 5(4.5) | 59(53.6) | 15(13.6) | 31(28.3) | 71.8％ |
As can be seen from Table 9, analyze through Ridit, there were significant differences (p＜0.01) for comprehensive therapeutic effect between two groups, and test group obviously is better than matched group.
2, two groups of curative effect to treat angina pectoris relatively see Table 10
Table 10 liang group curative effect to treat angina pectoris relatively
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate | p |
| Test group | 250 | 128(51.2) | 104(41.6) | 18(7.2) | 92.9％ | ＜0.01 |
| Matched group | 110 | 23(20.9) | 38(34.5) | 49(44.6) | 55.6％ |
As can be seen from Table 10, analyze through Ridit, there were significant differences (p＜0.01) for curative effect to treat angina pectoris between two groups, and test group obviously is better than matched group.
3, two groups of ECG curative effect relatively see Table 11
Table 11 liang group ECG curative effect relatively
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate | p |
| Test group | 250 | 72(27.9) | 66(35.3) | 112(36.8) | 55.1％ | ＜0.01 |
| Matched group | 110 | 19(9.7) | 16(32.3) | 75(58.1) | 32.0％ |
As can be seen from Table 11, analyze through Ridit, there were significant differences (p＜0.01) for ECG curative effect between two groups, and test group obviously is better than matched group.
4, two groups of nitroglycerin subtract the rate of stopping relatively, see Table 12
Table 12 a liang group nitroglycerin subtracts the rate of stopping relatively
| Group | The example number | Stop using | Decrement | Constant | Subtract the rate of stopping | p |
| Test group | 111 | 63(56.8) | 25(22.5) | 23(20.7) | 79.2％ | ＜0.05 |
| Matched group | 57 | 15(26.3) | 22(38.6) | 20(35.1) | 64.9％ |
As can be seen from Table 12, through chi-square analysis, there were significant differences (p＜0.05) for curative effect between two groups, and test group obviously is better than matched group.
5, two groups of treatment front and back doing well,improving situations see Table 13
Doing well,improving situation before and after the table 13 liang group treatment
| Symptom | The treatment group | Matched group | ||||||||
| The example number | Produce effects | Effectively | Invalid | Total effective rate | The example number | Produce effects | Effectively | Invalid | Total effective rate | |
| Uncomfortable in chest | 250 | 100 | 143 | 7 | 97.2％* | 110 | 40 | 47 | 23 | 79.1％ |
| Cardiopalmus | 243 | 155 | 78 | 10 | 95.9％* | 100 | 28 | 42 | 30 | 70.0％ |
| Breathe hard | 245 | 125 | 110 | 10 | 95.9％* | 106 | 41 | 35 | 30 | 74.5％ |
| Weak | 220 | 126 | 81 | 13 | 94.1％* | 98 | 22 | 44 | 32 | 67.3％ |
| Xerostomia | 213 | 97 | 95 | 21 | 90.1％* | 95 | 35 | 26 | 34 | 64.2％ |
| The side of body expands | 198 | 99 | 80 | 19 | 90.4％* | 80 | 33 | 27 | 20 | 75.0％ |
As can be seen from Table 13, analyze through Ridit, there were significant differences (* p＜0.05) for each symptom curative effect between two groups, and test group obviously is better than matched group.
Test group is light, in, the weight classification curative effect relatively, see Table 14
Table 14 test group is light, in, the weight classification curative effect relatively
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate |
| Slightly | 98 | 59(60.2) | 34(34.7) | 5(5.1) | 94.9％ |
| Moderate | 116 | 56(48.3) | 52(44.8) | 8(6.9) | 93.2％ |
| Severe | 36 | 13(36.1) | 18(50.0) | 5(13.9) | 86.3％ |
Two groups of patient's angina pectoriss are light, in, heavy curative effect analyzes there was no significant difference between the three (p＞0.05) through Ridit.
Six, safety evaluatio
All do inspections such as routine blood test, routine urinalysis, stool routine examination, liver function, kidney merit before two groups of patient treatments and after the treatment, all do not found obvious ANOMALOUS VARIATIONS.
Seven, conclusion
1, XINXINSHU JIAONANG is made up of seven flavor Chinese medicines such as Radix Ginseng, the Radix Astragali, has benefiting QI and nourishing blood, the effect of Yin-heart nurishing.Its clinical test results shows, is 95.7% to the viral myocarditis total effective rate, is 93.2% to the angina pectoris total effective rate, shows that XINXINSHU JIAONANG has significant curative effect to the type of deficiency of both QI and YIN thoracic obstruction, cardiopalmus (viral myocarditis, angina pectoris).
2, XINXINSHU JIAONANG treatment viral myocarditis ECG curative effect total effective rate is respectively 63.2%, and matched group electrocardiogram total effective rate is 41.9%, and there were significant differences (p＜0.01); XINXINSHU JIAONANG treatment angina pectoris ECG curative effect total effective rate is 55.2%, and matched group is 31.8%, and there were significant differences (p＜0.01).XINXINSHU JIAONANG obviously is better than matched group, and XINXINSHU JIAONANG has the good electrocardiogram effect that improves.
3, (viral myocarditis, angina pectoris) has uncomfortable in chest, cardiopalmus, breathes hard XINXINSHU JIAONANG to the type of deficiency of both QI and YIN thoracic obstruction, every symptom total effective rate such as weak is respectively 97.2%, 95.9%, 95.9%, 94.1%, all apparently higher than matched group (p＜0.05).Show that XINXINSHU JIAONANG can well improve symptom.
4, XINXINSHU JIAONANG is to difference nonsignificance (p＞0.05) between the acute stage of viral myocarditis, convalescent period, lag phase, the chronic phase curative effect, to anginal light, in, weigh difference not statistically significant (p＞0.05) between three grades the curative effect.Show that XINXINSHU JIAONANG is applicable to myocarditis acute stage, convalescent period, lag phase, chronic phase, and slight, moderate, severe angina pectoris.
5, untoward reaction is not seen in the XINXINSHU JIAONANG clinical trial, shows that XINXINSHU JIAONANG has good safety.
In a word, XINXINSHU JIAONANG is effective and safe on the treatment type of deficiency of both QI and YIN thoracic obstruction, cardiopalmus (viral myocarditis, angina pectoris).
The present invention is described in further detail below in conjunction with instantiation that the inventor provides.
The specific embodiment
Embodiment 1
Take by weighing each raw material according to following weight parts
55 parts of the Radixs Astragali, 30 parts of Radix Rehmanniae, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Radix Salviae Miltiorrhizaes, 30 parts of Radix Paeoniae Rubra, 15 parts of Ramulus Cinnamomi, 0.5 part of stem and leaf of Radix Ginseng total saponins.
55 parts of the Radixs Astragali, 30 parts of Radix Rehmanniae, 15 parts of Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, 30 parts of Radix Paeoniae Rubra, 15 parts of Ramulus Cinnamomi, 0.5 part of stem and leaf of Radix Ginseng total saponins.
Preparation method: the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Ramulus Cinnamomi, the Radix Ginseng seven flavor medicine is got Radix Paeoniae Rubra earlier and is ground into fine powder for 10 parts, and is standby, 15 parts of Radix Salviae Miltiorrhizaes and residue Radix Paeoniae Rubra add 5 times of amount 95% alcohol reflux secondaries for 20 parts, each 2 hours, merge the stream extract, filter, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.35 (60 ℃ of heat are surveyed), vacuum drying, be ground into fine powder, standby, the alcohol extraction medicinal residues and the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Ramulus Cinnamomi, decoct with water three times, for the first time add 10 times of water gagings, decocted 2 hours, add 8 times of water gagings for the second time, decocted 1.5 hours, add 6 times of water gagings for the third time, decocted 1 hour, merge three times decoction liquor, subtract and be compressed to the thick paste that relative density is 1.35 (60 ℃ of heat are surveyed), add the Radix Paeoniae Rubra fine powder, stir vacuum drying, be ground into fine powder, standby, ginsenoside's powder and above-mentioned fine powder be mix homogeneously repeatedly, granulates with 95% ethanol, 16 mesh sieves, oven dry, 16 mesh sieve granulate are sub-packed in the capsule, sterilization back packing.
Usage: every day 3 times, each 4,3 months is a course of treatment.
Embodiment 2
Take by weighing each component raw material according to following weight parts:
65 parts of the Radixs Astragali, 40 parts of Radix Rehmanniae, 22 parts of Fructus Schisandrae Chinensis, 22 parts of Radix Salviae Miltiorrhizaes, 40 parts of Radix Paeoniae Rubra, 22 parts of Ramulus Cinnamomi, 1.5 parts of stem and leaf of Radix Ginseng total saponins.
Preparation method: the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Ramulus Cinnamomi, the Radix Ginseng seven flavor medicine is got Radix Paeoniae Rubra earlier and is ground into fine powder for 13 parts, and is standby, 22 parts of Radix Salviae Miltiorrhizaes and residue Radix Paeoniae Rubra add 5 times of amount 95% alcohol reflux secondaries for 27 parts, each 2 hours, merge the stream extract, filter, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.35 (60 ℃ of heat are surveyed), vacuum drying, be ground into fine powder, standby, the alcohol extraction medicinal residues and the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Ramulus Cinnamomi, decoct with water three times, for the first time add 10 times of water gagings, decocted 2 hours, add 8 times of water gagings for the second time, decocted 1.5 hours, add 6 times of water gagings for the third time, decocted 1 hour, merge three times decoction liquor, subtract and be compressed to the thick paste that relative density is 1.35 (60 ℃ of heat are surveyed), add the Radix Paeoniae Rubra fine powder, stir vacuum drying, be ground into fine powder, standby, ginsenoside's powder and above-mentioned fine powder be mix homogeneously repeatedly, granulates with 95% ethanol, 16 mesh sieves, oven dry, 16 mesh sieve granulate are sub-packed in the capsule, sterilization back packing.
Usage is with embodiment 1.
Embodiment 3
Take by weighing each component raw material according to following weight parts:
60 parts of the Radixs Astragali, 36 parts of Radix Rehmanniae, 18 parts of Fructus Schisandrae Chinensis, 18 parts of Radix Salviae Miltiorrhizaes, 36 parts of Radix Paeoniae Rubra, 18 parts of Ramulus Cinnamomi, 1 part of stem and leaf of Radix Ginseng total saponins.
Preparation method: the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Ramulus Cinnamomi, the Radix Ginseng seven flavor medicine is got Radix Paeoniae Rubra earlier and is ground into fine powder for 12 parts, and is standby, 18 parts of Radix Salviae Miltiorrhizaes and residue Radix Paeoniae Rubra add 5 times of amount 95% alcohol reflux secondaries for 24 parts, each 2 hours, merge the stream extract, filter, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.35 (60 ℃ of heat are surveyed), vacuum drying, be ground into fine powder, standby, the alcohol extraction medicinal residues and the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Ramulus Cinnamomi, decoct with water three times, for the first time add 10 times of water gagings, decocted 2 hours, add 8 times of water gagings for the second time, decocted 1.5 hours, add 6 times of water gagings for the third time, decocted 1 hour, merge three times decoction liquor, subtract and be compressed to the thick paste that relative density is 1.35 (60 ℃ of heat are surveyed), add the Radix Paeoniae Rubra fine powder, stir vacuum drying, be ground into fine powder, standby, ginsenoside's powder and above-mentioned fine powder be mix homogeneously repeatedly, granulates with 95% ethanol, 16 mesh sieves, oven dry, 16 mesh sieve granulate are sub-packed in the capsule, sterilization back packing.
Usage is with embodiment 1.
Claims (4)
1. medicine for the treatment of the thoracic obstruction, cardiopalmus is characterized in that this medicine made by following bulk drugs: Radix Astragali 55-65 part, Radix Rehmanniae 30-40 part, Fructus Schisandrae Chinensis 15-22 part, Radix Salviae Miltiorrhizae 15-22 part, Radix Paeoniae Rubra 30-40 part, Ramulus Cinnamomi 15-22 part, stem and leaf of Radix Ginseng total saponins 0.5-1.5 part.
2. a kind of medicine for the treatment of the thoracic obstruction, cardiopalmus according to claim 1 is characterized in that the consumption of each crude drug is: 60 parts of the Radixs Astragali, 36 parts of Radix Rehmanniae, 18 parts of Fructus Schisandrae Chinensis, 18 parts of Radix Salviae Miltiorrhizaes, 36 parts of Radix Paeoniae Rubra, 18 parts of Ramulus Cinnamomi, 1 part of stem and leaf of Radix Ginseng total saponins.
3. a kind of medicine for the treatment of the thoracic obstruction, cardiopalmus according to claim 1 and 2 is characterized in that this medicine makes pill or powder or electuary or unguentum or capsule or oral liquid.
4. the preparation method of the treatment thoracic obstruction as claimed in claim 1 or 2, cardiopalmus medicine is characterized in that:
(A) 1/3rd of the Radix Paeoniae Rubra consumption be ground into fine powder;
(B) Radix Salviae Miltiorrhizae and residue Radix Paeoniae Rubra adding 4.5-5.5 doubly measure 90%-95% ethanol, reflux, extract, secondary, each 1.5-2.5 hour, merge extractive liquid;
(C) extracting solution filters, and filtrate recycling ethanol is concentrated into the thick paste that relative density is 1.3-1.4, and the thick paste vacuum drying is ground into fine powder;
(D) the alcohol extraction medicinal residues and the Radix Astragali, Radix Rehmanniae, Fructus Schisandrae Chinensis, Ramulus Cinnamomi decoct with water three times, add 8-12 times of water gaging for the first time, decocted 1.5-2.5 hour, and added 6-10 times of water gaging for the second time, decocted 1.0-2.0 hour, add 5-7 times of water gaging for the third time, decocted 0.5-1.5 hour, merge three times decoction liquor;
(E) decoction liquor subtracts and is compressed to the thick paste that relative density is 1.3-1.4;
(F) thick paste adds the Radix Paeoniae Rubra fine powder, stirs, and vacuum drying is ground into fine powder;
(G) fine powder and ginsenoside's powder mix homogeneously are granulated with 90%-95% ethanol 16 mesh sieves, oven dry, granulate, sterilization back packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100733427A CN100333750C (en) | 2005-06-02 | 2005-06-02 | Traditional Chinese medicine preparation for treating thoracic obstruction and palpitation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100733427A CN100333750C (en) | 2005-06-02 | 2005-06-02 | Traditional Chinese medicine preparation for treating thoracic obstruction and palpitation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1698804A CN1698804A (en) | 2005-11-23 |
| CN100333750C true CN100333750C (en) | 2007-08-29 |
Family
ID=35475158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100733427A Active CN100333750C (en) | 2005-06-02 | 2005-06-02 | Traditional Chinese medicine preparation for treating thoracic obstruction and palpitation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100333750C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547844A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Traditional Chinese medicine for treating chest stuffiness and pains with syndrome of yang deficiency and cold congelation and preparation method thereof |
| CN104547973A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Health traditional Chinese medicine for treating chest obstruction and preparation method thereof |
| CN103550689B (en) * | 2013-10-26 | 2015-11-04 | 迟荣 | A kind of Chinese medicine composition for the treatment of the thoracic obstruction |
| CN104127574A (en) * | 2014-07-31 | 2014-11-05 | 赵兰 | Application of traditional Chinese medicine composition to prepare blood-pressure-reducing medicines |
| CN104857439A (en) * | 2015-05-23 | 2015-08-26 | 济南伟传信息技术有限公司 | Medicine for treating pericarditis |
| CN105727044A (en) * | 2016-04-15 | 2016-07-06 | 宁波优美科新材料有限公司 | Drug for treating obstruction of qi in the chest |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362255A (en) * | 2001-12-25 | 2002-08-07 | 哈药集团世一堂制药厂 | Coronary heart disease treating Chinese medicine and its preparation |
| CN1537554A (en) * | 2003-04-16 | 2004-10-20 | 安徽古井集团九方制药有限公司 | Traditional Chinese medicine composition for treating cardiovascular disease |
-
2005
- 2005-06-02 CN CNB2005100733427A patent/CN100333750C/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362255A (en) * | 2001-12-25 | 2002-08-07 | 哈药集团世一堂制药厂 | Coronary heart disease treating Chinese medicine and its preparation |
| CN1537554A (en) * | 2003-04-16 | 2004-10-20 | 安徽古井集团九方制药有限公司 | Traditional Chinese medicine composition for treating cardiovascular disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1698804A (en) | 2005-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100457176C (en) | Chinese medicinal preparation for curriculum of physical and fatigue reducing | |
| CN102078520B (en) | Chinese medicinal preparation for treating nervous headache and preparation method thereof | |
| CN1994451B (en) | Chinese medicinal composition for treating depression, its preparation method and application | |
| CN1383846A (en) | Heart-strengthening and blood circulation-promoting liquid medicine for treating heart diseases | |
| CN102772748B (en) | Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof | |
| CN100333750C (en) | Traditional Chinese medicine preparation for treating thoracic obstruction and palpitation and preparation method thereof | |
| CN101524469B (en) | Chinese herbal medicine compound preparation for treating congestive heart failure and preparation method thereof | |
| CN100493597C (en) | Medicine composition for treating neurosis | |
| CN100488558C (en) | Medicament for treating heart disease and preparation process thereof | |
| CN101716236B (en) | Chinese medicinal composition for adjunctively treating left ventricular insufficiency after acute myocardial infarction and preparation method thereof | |
| CN108014267A (en) | A kind of liter is immunized, reducing blood lipid, the Chinese medicine composition and preparation method thereof for protecting heart and brain | |
| CN1970050B (en) | Pharmaceutical composition for treating arrhythmia and preparation process thereof | |
| CN102266481B (en) | Chinese medicinal preparation for treating chronic cerebral circulation insufficiency | |
| CN102228596B (en) | Pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris | |
| CN102274357B (en) | Pharmaceutical composition for treating coronary arteriosclerotic heart disease and preparation method thereof | |
| CN102204956B (en) | Chinese medicinal composition used at stroke recovery period and preparation method thereof | |
| CN105561184A (en) | Medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and preparation method thereof | |
| CN101417075B (en) | Traditional Chinese medicine for treating respiratory system disease | |
| CN100502937C (en) | Chinese medicine composition for treating cardiovascular disease and its preparing method | |
| CN110882347A (en) | A Chinese medicinal composition for treating cardiovascular diseases | |
| CN104740579B (en) | Premenstrual peace piece and its preparation technology | |
| CN103919852A (en) | Blending method of heart-protecting pill mixed powder containing musk for preventing and treating chronic cardiac insufficiency and heart failure | |
| CN105477373B (en) | Chinese patent medicine for treating myocardial infarction and preparation method thereof | |
| CN102772665B (en) | Traditional Chinese medicine preparation for treating yin deficiency and internal heat type vital myocarditis and preparation method thereof | |
| CN102309561A (en) | Pharmaceutical composition used for preventing and treating urarthritis and hyperuricemia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YANGLING DONGKE MAIDISEN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHAO DONGKE Effective date: 20100617 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 712100 NO.8, XINQIAO ROAD, YANGLING DEMONSTRATION ZONE, SHANXI PROVINCE TO:710043 4/F, DONGXINGKEJI BUILDING, XINCHENG SCI-TECH INDUSTRY PARK, NO.1, XINKE ROAD, XI AN CITY, SHANXI PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20100617 Address after: 710043 4 floor, Dongxing science and technology building, Xincheng science and Technology Industrial Park, No. 1, Xinke Road, Shaanxi, Xi'an Patentee after: Dongke Maidisen Pharmaceutical Co., Ltd., Yangling Address before: 712100 No. 8 Xinqiao Road, Yangling demonstration area, Shaanxi Patentee before: Zhao Dongke |
|
| ASS | Succession or assignment of patent right |
Owner name: SHAANXI DONGKE PHARMACEUTICAL LLC Free format text: FORMER OWNER: DONGKE MAIDISEN PHARMACEUTICAL CO., LTD., YANGLING Effective date: 20150107 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 710043 XI AN, SHAANXI PROVINCE TO: 712100 XI AN, SHAANXI PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20150107 Address after: 712100 No. 8 Xinqiao Road, Yangling demonstration area, Shaanxi, Xi'an Patentee after: SHAANXI DONGKE PHARMACEUTICAL CO., LTD. Address before: 710043 4 floor, Dongxing science and technology building, Xincheng science and Technology Industrial Park, No. 1, Xinke Road, Shaanxi, Xi'an Patentee before: Dongke Maidisen Pharmaceutical Co., Ltd., Yangling |