CN1325101C - Capsule for radix astragalis and red-rooted salvia root - Google Patents
Capsule for radix astragalis and red-rooted salvia root Download PDFInfo
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Abstract
The present invention relates to a jingqi shuangshen capsule, which belongs to the field of traditional Chinese medicines and is prepared from pure traditional Chinese medicines of astragalus root, red sage root, ginseng and siberian solomonseal rhizome according to a traditional preparation process of tradition Chinese medicines. The capsule is pure traditional Chinese medicine preparation, which has the advantages of no toxic or side effect and obvious therapeutic effect and has the functions of invigorating qi, nourishing yin, promoting blood circulation, removing blood stasis, nourishing the heart and tranquilizing mind by the combination of all the medicines. The capsule has obvious therapeutic effects on the treatment of diseases of palpitation, short breath, dizziness, headache, lassitude, hypodynamia, tinnitus, giddiness, numbness of the limbs, insomnia and amnesia due to cardio-cerebrovascular diseases.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of capsule for radix astragalis and red-rooted salvia root for the treatment of cardiovascular and cerebrovascular disease.
Background technology
Cardiovascular and cerebrovascular disease is a kind of disease of serious harm people ' s health.Reasons such as how angry by being worried this disease is, eating and drinking without temperance cause, so that imbalance of YIN and YANG, abnormal functional activities of ZANG FUorgans, QI and blood entanglement, sick position master is relevant at the heart, liver,spleen,kidney, its symptom belongs to deficiency in origin and excess in superficiality, especially gerontal patient, chronic deficiency of five viscera human settlements are many, adopt strengthening the body resistance, regulating YIN and YANG QI and blood multipotency improves patient's body constitution significantly, obtains the good effect of preventing and curing diseases.
Doctor trained in Western medicine so-called " cardiovascular and cerebrovascular disease " belongs to the scope of diseases such as the traditional Chinese medical science " angina pectoris ", " cardiopathia of fainting ", " obstruction of heart-QI ", " thoracic obstruction ", " cardiopalmus ", " apoplexy " more, with ictal pain behind the thoracic dorsal or suddenly confused servant, facial hemiparalysis, hemiplegia are main symptom, be more common in more than 40 years old in, the old people.How angry by being worried, due to eating and drinking without temperance, heart yang blood and qi empty partially consequently imbalance of YIN and YANG, abnormal functional activities of ZANG FUorgans, the QI and blood entanglement.The traditional Chinese medical science thinks that coronary heart disease mainly is due to the heart arteries and veins addiction stasis of blood, causes that the main cause that the heart arteries and veins stasis of blood stagnates can reduce " YIN-cold cohesion, turbid the moon, the qi depression to blood stasis of closing of expectorant " etc.In addition, nervous for a long time, surfeit is rich, also can influence the operation of heart arteries and veins, cause the heart arteries and veins stasis of blood to stagnate, produces diseases such as pained, the thoracic obstruction, so but the heart feeling pulse stasis of blood is stagnant, main still because due to old, the zang-fu disharmony, sick position is at the heart, and is but closely related with liver,kidney,spleen, stomach, as worn with age, the tight cloudy blood of liver is hindered, with the passing of time deficiency of YIN affecting YANG, flaccidity of the heart-yang easily causes heart stasis of blood plug not smooth, old in addition QI and blood degradation, the deficiency of vital energy can not be suitable, blood stasis arteries and veins resistance, obstructed and pain.And send out the thoracic obstruction, pained disease.Therefore, yin and yang qi and blood disorder be disease this, qi depression to blood stasis be primary disease mark, clinical findings mostly is deficiency in origin and excess in superficiality, controls suitable giving consideration to both the incidental and fundamental, i.e. benefiting QI for activating blood circulation blood stasis dispelling.
Alleged " apoplexy " of apoplexy and doctor trained in Western medicine is identical substantially, comprise cerebral hemorrhage, cerebral thrombosis, cerebral embolism and temporal cerebral ischemia seizure etc., how angry by being worried, overwork, reason such as excessive drinking, surfeit delicious food so that negative and positive lose in down, liver-yin opens cruelly, endogenous wind turn, QI and blood are contrary disorderly, folder expectorant folder fire, horizontal scurry passages through which vital energy circulates hoodwink thinking and take place suddenly to fall forward dusk, all diseases of hemiplegia.By clinical findings, it is more to belong to empty Blood stasis, therefore controls when the benefiting QI for activating blood circulation blood stasis dispelling, reaches by the inclined to one side void of regulating the internal organs yang blood and qi and recovers the yang blood and qi relative equilibrium and set upright with eliminating evil purpose.And the medicine cost of controlling cardiovascular and cerebrovascular disease commonly used at present is higher, and patient economy burden is excessive, and curative effect is not remarkable yet, even the medicine that has also has very big toxic and side effects.
Summary of the invention
The object of the present invention is to provide a kind of capsule for radix astragalis and red-rooted salvia root for the treatment of cardiovascular and cerebrovascular disease, it is higher to have solved existing treatment cardiovascular and cerebrovascular disease Chinese medicine cost, and patient economy burden is excessive, and curative effect does not significantly reach problems such as toxic side effect.
According to the theory of Chinese medical science and the clinical findings of motherland, it is more that cardiovascular and cerebrovascular disease belongs to empty Blood stasis more, therefore controls when the benefiting QI for activating blood circulation blood stasis dispelling, reaches by the inclined to one side void of regulating the internal organs yang blood and qi and recover the yang blood and qi relative equilibrium and set upright with eliminating evil purpose.Therefore, the pure Chinese herbal medicine of the selected following all flavors of the present invention is made by traditional Chinese medicine preparation technology.Its concrete prescription following (by ratio of weight and the number of copies):
185～265 parts of 230～315 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
10～33 parts of 5～45 parts of Rhizoma Polygonatis of Radix Ginseng
Optimum ratio of the present invention is (by ratio of weight and the number of copies):
225 parts of 275 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
23 parts of 25 parts of Rhizoma Polygonatis of Radix Ginseng
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral formulations.Preferable preparation technique of the present invention is as follows:
Above four Chinese medicine is got Radix Ginseng, the Radix Astragali is ground into fine powder for 65～150 parts, sieves mixing; All the other Radixs Astragali, Rhizoma Polygonati decoct with water twice, for the first time add 10 times of amounts, the amount of frying in shallow oil 2 hours adds 8 times of amounts for the second time, decocted 1.5 hours, collecting decoction filters, filtrate be concentrated into temperature in the time of 40 ℃～100 ℃, relative density is 1.10～1.30, adding ethanol makes and contains the alcohol amount and reach 55%～75%, placement is spent the night, and filters filtrate for later use; Radix Salviae Miltiorrhizae adds 70% alcohol reflux twice, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters, and merges with above-mentioned filtrate, reclaim ethanol, and be concentrated into temperature in the time of 20 ℃～80 ℃, relative density is 1.10～1.30 thick paste, adds 1/2 amount Radix Ginseng, Radix Astragali fine powder, mixing, crushed after being dried is sieved, dry again, add residue Radix Ginseng, Radix Astragali fine powder, mixing, granulate, promptly encapsulated.
[character] this product is a capsule, and the content rufous is to tan granule; Gas perfume (or spice), mildly bitter flavor.
[specification] every dress 0.23g.
[function cures mainly] boosting qi and nourishing yin, blood circulation promoting and blood stasis dispelling, tranquilizing by nourishing the heart.Be applicable to the shortness of breath and palpitation of cardiovascular and cerebrovascular disease, dizziness headache, fatigue and weakness, the tinnitus dim eyesight, numb limbs and tense tendons loses the forgetful grade of eye disease.
[usage and dosage] is oral, one time 4,3 times on the one.
Among the present invention:
Monarch drug in the Radix Astragali side of being, Radix Astragali sweet in the mouth temperature, the spleen reinforcing lung, sending up the lucid YANG, system blood is held up deficient.Minister is gone into the blood GUIXIN with Radix Salviae Miltiorrhizae, and blood stasis dispelling stagnates, and the promoting the circulation of blood arteries and veins has row and not broken characteristics; Radix Salviae Miltiorrhizae is joined the Radix Astragali, and the monarch and his subjects are collaborative, and QI and blood is taken into account, revisal and do not stay heresy, and blood stasis dispelling and just not hindering solves deficiency in origin and excess in superficiality, the time of the gas azotemia stasis of blood satisfactory to both partiesly.Assistant is with Radix Ginseng, the Radix Ginseng sweet in the mouth, and strongly invigorating primordial QI is changed precise and tinyly, gives birth to negative and positive, supporting the five internal organs and blood vessels, to for helping intensive culture god's key medicine, join the gas of monarch drug with big spleen reinforcing lung, is the method from this treatment, the Radix Astragali and ginseng compatibility have the merit of tonifying vital QI, and it is unobstructed to be equipped with the Radix Salviae Miltiorrhizae venation, tonify without causing stagnation.Make with Rhizoma Polygonati, the Rhizoma Polygonati sweet in the mouth is returned spleen, lung, kidney channel, energy enriching spleen-QI, strengthening the spleen the moon, dry, the smart effect of kidney tonifying of lung moistening.
Good effect of the present invention is: medicine is a pure Chinese medicinal preparation, has no side effect, and is evident in efficacy, and all medicine contracts have boosting qi and nourishing yin, blood circulation promoting and blood stasis dispelling, the effect of tranquilizing by nourishing the heart.To the shortness of breath and palpitation of cardiovascular and cerebrovascular disease, dizziness headache, fatigue and weakness, the tinnitus dim eyesight, numb limbs and tense tendons, diseases such as insomnia forgetfulness have significant curative effect.
For verifying therapeutic effect of the present invention, 121 routine cardiovascular and cerebrovascular disease patients are used the capsule for radix astragalis and red-rooted salvia root treatment, obtained promising result, now be summarized as follows:
One, clinical data
Case is selected: observe in 121 examples male 69 examples, women 52 examples; Age is 6 examples below 40 years old, 40～60 years old 57 example, above 58 examples of 61 examples; The course of disease: 1 year with interior 21 examples, 1～3 year 33 example, 3～6 years 27 examples, 40 examples more than 6 years.Office rank: cadre's 82 examples, workman and family members' 39 examples.
Two, diagnostic criteria: carry out by " the dialectical reference standard of Chinese medicine deficiency-syndrome " that national combination of Chinese and Western medicine deficiency syndrome and senile disease Professional Committee formulated in 1986.All clinical manifestations are shortness of breath and palpitation, lassitude, inappetence, have a dizzy spell, Hiccough and deaf, little sleep disturbed by dreams, numb limbs and tense tendons, syndrome of deficiency of QI such as forgetful or to have blood stasis concurrently be main clinical manifestation, and the disease such as coronary heart disease, epigastric pain due to wind pathogen, myocarditis, arteriosclerosis, cerebral infarction that is equivalent to modern medicine all can be classified the object of observation as.
Three, Therapeutic Method:
1, adopts Self-control method, promptly, compare observation self medication front and back symptom.
2, allly meet diagnostic criteria person, fill in symptom, sign, routine urinalysis, liver function, electrocardiographic examination by observing requirement, some cases is done item inspections such as routine blood test, blood three fat, hemorheology or cardiac function; Other stop using during the treatment about medicine, and after finishing the course of treatment, its result carries out statistical procedures.
3, observe medicine and medication: " capsule for radix astragalis and red-rooted salvia root " provided by Jilin Changbaishan Pharmaceutical Group Co., Ltd..Medication: oral, each 4～6,3 times on the one, one month is a course of treatment.
Four, observed result
1, criterion of therapeutical effect: divide produce effects, effective, invalid three grades by the new drug research guideline.Symptom is all evaluated with integral and calculating.3 minutes: tell that initiatively symptom or symptom occur repeatedly; 2 minutes: heavy or be interrupted and occur when light during symptom; 1 minute: mild symptoms or appearance once in a while; 0 minute: non-evident sympton.
Produce effects: treatment back transference cure or integrated value descend 〉=2/3;
Effectively: treatment back integrated value descends 2/3～1/3
Invalid: treatment back integrated value decline less than 1/3;
2, treatment observed result: observe in 121 examples, produce effects 70 examples account for 57.9%; Effective 47 examples account for 35.5%; Invalid 4 examples account for 3.3%.Total effective rate is 96.7%, and total obvious effective rate is 57.9%, improves the symptom curative effect and sees Table 1.
Table 1 symptom curative effect table
| n | Before controlling | After controlling | u P | ||||||
| +++ | ++ | + | - | +++ | ++ | + | - | ||
| Palpitation＜0.01 121 lassitudes 121 poor appetite 121 uncomfortable in chest 121 Hiccough and deafs, 121 little sleep disturbed by dreams, 121 forgetful 121 extremity numbness, 121 soreness and weakness of waist and knees 121 of having a dizzy spell | 121 37 47 15 49 30 47 35 43 43 | 70 51 47 34 49 38 28 36 33 42 | 30 23 23 41 17 22 29 33 20 25 | 13 10 4 31 6 31 17 17 25 11 | 7 0 0 0 0 3 1 3 2 2 | 1 7 18 5 11 8 13 16 13 22 | 20 49 42 24 48 33 45 44 45 37 | 54 65 61 92 62 77 62 58 61 60 | 468.919 8.541＜0.01 8.495＜0.01 7.29＜0.01 8.584＜0.01 7.146＜0.01 7.847＜0.01 7.222＜0.01 7.673＜0.01 8.113＜0.01 |
By table 1 as seen, the present invention improves significantly to deficiency of vital energy symptoms such as shortness of breath and palpitation, uncomfortable in chest, lassitudes, learns by statistics and handles significant difference (P＜0.01).
3, the influence to heart rate, blood pressure, the length of one's sleep sees Table 2.
Table 2 treatment front and back are to the influence of heart rate, blood pressure, the length of one's sleep
By table 2 as seen, the present invention can alleviate heart rate, make blood pressure drops trend, can increase the length of one's sleep, learns by statistics and handles significant difference.
4, to the influence of blood fat, see Table 3.
Blood Lipid (mmlo/L before and after table 3 treatment
)
| n | Before controlling | After controlling | t | P | |
| chol TG HDL | 60 60 60 | 5.27±1.47 1.57±0.85 1.09±0.44 | 4.48±1.01 1.29±0.51 1.18±0.39 | 4.169 3.156 1.24 | ＜0.01 ＜0.0l ＞0.05 |
Variation by blood fat before and after the 60 example treatments is observed, and illustrates that the present invention has downward trend (P＜0.01) to serum cholesterol and triglyceride; HDL-C does not have obvious influence, no significant difference before and after the treatment.
5, blood is become the influence of learning, see Table 4.
Before and after table 4 treatment to hemorheological influence (
)
| n | Before controlling | After controlling | t | P | |
| Plasma viscosity packed cell volume whole blood contrast viscosity | 30 30 30 | 1.95±0.18 45.5±5.66 5.96±1.4 | 1.82±0.31 43.1±4.01 5.68±1.18 | 2.17 3.91 1.89 | ＜0.05 ＜0.05 ＞0.05 |
Observe by hemorheology before and after the 30 routine patient, show that the present invention can improve blood viscosity, antithrombotic forms.
Five, safety detects
121 routine patients have no adverse effects to blood, routine urinalysis, hepatic and renal function after smelting is treated, and other toxic and side effects do not occur, prove this product safety non-toxic.
Six, brief summary:
By 121 routine deficiency of vital energy disease patients clinicals are observed, illustrate capsule for radix astragalis and red-rooted salvia root to shortness of breath and palpitation, lassitude, inappetence due to the deficiency of vital energy, have a dizzy spell, Hiccough and deaf, little sleep disturbed by dreams, limb fiber crops, disease such as forgetful have tangible curative effect.Liver, renal function are had no adverse effects, and can reduce blood viscosity, antithrombotic forms, and reduces serum cholesterol and triglyceride, and elevated blood pressure is still had reduction trend, increases the length of one's sleep, and other side effect do not appear in hypermnesis.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limits the present invention by any way.Under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall in the claim scope of the present invention.
Embodiment 1:
Get Radix Ginseng 5g, Radix Astragali 65g is ground into fine powder, sieves mixing; All the other Radix Astragali 165g, Rhizoma Polygonati 10g decoct with water twice, for the first time add 10 times of amounts, decocted 2 hours, add 8 times of amounts for the second time, decocted 1.5 hours, collecting decoction filters, filtrate be concentrated into temperature in the time of 40 ℃, relative density is 1.30, adding ethanol makes and contains the alcohol amount and reach 55%, placement is spent the night, and filters filtrate for later use; Radix Salviae Miltiorrhizae 185g adds 60% alcohol reflux twice, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters, and merges with above-mentioned filtrate, reclaim ethanol, and be concentrated into temperature in the time of 20 ℃, relative density is 1.30 thick paste, adds 1/2 amount Radix Ginseng, Radix Astragali fine powder, mixing, crushed after being dried is sieved, dry again, add residue Radix Ginseng, Radix Astragali fine powder, mixing, granulate, promptly encapsulated.
Embodiment 2:
Get Radix Ginseng 25g, Radix Astragali 110g is ground into fine powder, sieves mixing; All the other Radix Astragali 165g, Rhizoma Polygonati 23g decoct with water twice, for the first time add 10 times of amounts, decocted 2 hours, add 8 times of amounts for the second time, decocted 1.5 hours, collecting decoction filters, filtrate be concentrated into temperature in the time of 80 ℃, relative density is 1.20, adding ethanol makes and contains the alcohol amount and reach 65%, placement is spent the night, and filters filtrate for later use; Radix Salviae Miltiorrhizae 225g adds 70% alcohol reflux twice, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters, and merges with above-mentioned filtrate, reclaim ethanol, and be concentrated into temperature in the time of 50 ℃, relative density is 1.20 thick paste, adds 1/2 amount Radix Ginseng, Radix Astragali fine powder, mixing, crushed after being dried is sieved, dry again, add residue Radix Ginseng, Radix Astragali fine powder, mixing, granulate, promptly encapsulated.
Embodiment 3:
Get Radix Ginseng 45g, Radix Astragali 150g is ground into fine powder, sieves mixing; All the other Radix Astragali 165g, Rhizoma Polygonati 33g decoct with water twice, for the first time add 10 times of amounts, the amount of frying in shallow oil 2 hours adds 8 times of amounts for the second time, decocted 1.5 hours, collecting decoction filters, filtrate be concentrated into temperature in the time of 100 ℃, relative density is 1.10, adding ethanol makes and contains the alcohol amount and reach 75%, placement is spent the night, and filters filtrate for later use; Radix Salviae Miltiorrhizae 265g adds 80% alcohol reflux twice, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters, and merges with above-mentioned filtrate, reclaim ethanol, and be concentrated into temperature in the time of 80 ℃, relative density is 1.10 thick paste, adds 1/2 amount Radix Ginseng, Radix Astragali fine powder, mixing, crushed after being dried is sieved, dry again, add residue Radix Ginseng, Radix Astragali fine powder, mixing, granulate, promptly encapsulated.
Claims (3)
1, a kind of capsule for radix astragalis and red-rooted salvia root for the treatment of cardiovascular and cerebrovascular disease is characterized in that: make that its active component raw material medicine is made up of the component of following weight proportioning:
185～265 parts of 230～315 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
10～33 parts of 5～45 parts of Rhizoma Polygonatis of Radix Ginseng.
2, a kind of capsule for radix astragalis and red-rooted salvia root for the treatment of cardiovascular and cerebrovascular disease according to claim 1 is characterized in that: make that its active component raw material medicine is made up of the component of following weight proportioning:
225 parts of 275 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
23 parts of 25 parts of Rhizoma Polygonatis of Radix Ginseng.
3, the capsule for radix astragalis and red-rooted salvia root of treatment cardiovascular and cerebrovascular disease according to claim 1 and 2 is characterized in that: it is made according to following method:
Above four Chinese medicine is got Radix Ginseng, the Radix Astragali is ground into fine powder for 65～150 parts, sieves mixing; All the other Radixs Astragali, Rhizoma Polygonati decoct with water twice, for the first time add 10 times of amounts, decocted 2 hours, add 8 times of amounts for the second time, decocted 1.5 hours, collecting decoction filters, filtrate be concentrated into temperature in the time of 40 ℃～100 ℃, relative density is 1.10～1.30, adding ethanol makes and contains the alcohol amount and reach 55%～75%, placement is spent the night, and filters filtrate for later use; Radix Salviae Miltiorrhizae adds 60%～80% alcohol reflux twice, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filters, and merges with above-mentioned filtrate, reclaim ethanol, and be concentrated into temperature in the time of 20 ℃～80 ℃, relative density is 1.10～1.30 thick paste, adds 1/2 amount Radix Ginseng, Radix Astragali fine powder, mixing, crushed after being dried is sieved, dry again, add residue Radix Ginseng, Radix Astragali fine powder, mixing, granulate, promptly encapsulated.
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| CN1325101C true CN1325101C (en) | 2007-07-11 |
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| CN101878919A (en) * | 2010-06-29 | 2010-11-10 | 梁丽婵 | Ginseng roasted goose and manufacturing method thereof |
| CN102885984A (en) * | 2012-10-29 | 2013-01-23 | 葛恩民 | Pharmaceutical composition for treating hypertension |
| CN103948882A (en) * | 2014-02-27 | 2014-07-30 | 香港嘉峰医药血栓科技开发有限公司 | Traditional Chinese medicine for treating thrombus |
| CN105497515B (en) * | 2015-12-29 | 2019-03-19 | 吉林省现代中药工程研究中心有限公司 | A kind of two ginseng composition of smart stilbene with oxygen lack resistant function |
| CN108732266B (en) * | 2018-04-18 | 2020-11-13 | 吉林修正药业新药开发有限公司 | Method for constructing HPLC characteristic spectrum of capsule containing radix astragali and radix codonopsis pilosulae |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078635A (en) * | 1992-05-14 | 1993-11-24 | 包鸿延 | A kind of compound method for the treatment of leukemia Chinese medicine |
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078635A (en) * | 1992-05-14 | 1993-11-24 | 包鸿延 | A kind of compound method for the treatment of leukemia Chinese medicine |
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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