CN117942297A - Qijiao vein relaxing lotion, preparation method and application - Google Patents
Qijiao vein relaxing lotion, preparation method and application Download PDFInfo
- Publication number
- CN117942297A CN117942297A CN202311759412.9A CN202311759412A CN117942297A CN 117942297 A CN117942297 A CN 117942297A CN 202311759412 A CN202311759412 A CN 202311759412A CN 117942297 A CN117942297 A CN 117942297A
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- Prior art keywords
- parts
- lotion
- astragalus
- root
- vein relaxing
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Abstract
The invention relates to astragalus membranaceus and pepper vein relaxing lotion, a preparation method and application thereof, wherein the astragalus membranaceus and pepper vein relaxing lotion comprises 29-31 parts by weight of raw astragalus membranaceus, 14-16 parts by weight of medicinal cyathula root, 29-31 parts by weight of radix clematidis, 19-21 parts by weight of prepared aconite root, 9-11 parts by weight of asarum, 29-31 parts by weight of ligusticum wallichii, 29-31 parts by weight of cassia twig, 19-21 parts by weight of pericarpium zanthoxyli and 29-31 parts by weight of radix salviae miltiorrhizae. The invention can be used for treating diabetic neuropathy, thromboangiitis obliterans, venous embolism of lower limbs, gout, osteoarthritis and rheumatoid arthritis by selecting specific medicinal components for proportioning, and has particularly excellent curative effect on the diabetic neuropathy; the invention has reliable curative effect, simple operation, economy and safety.
Description
Technical Field
The invention relates to an external lotion for dredging collaterals, in particular to a astragalus membranaceus and pepper vein relaxing lotion, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations.
Background
Diabetic neuropathy is a common complication of diabetes mellitus, the pathological mechanism of which is very complex, and hyperglycemia and microangiopathy are the main pathogenesis thereof. The distal symmetric neuropathy is mainly manifested as numbness, pain, hyperalgesia, and myasthenia, which seriously affect the life quality of patients.
There are a number of tests to distinguish between specific neurological lesions, but pain treatment and assessment is often omitted, missing the best treatment occasion. The combination of measures such as controlling blood sugar and nerve nutrition, improving circulation, reasonably selecting analgesic drugs and nerve blocks is the best strategy for treating and delaying diabetic neuropathy.
Currently, in the field of treatment of diabetic neuropathy, there are many drugs, such as epalrestat tablets, which are used for preventing, improving and treating peripheral nerve disorders (numbness, pain), vibration paresthesia and heart beat abnormality (showing an increase in glycosylated hemoglobin value) which are complicated with diabetes.
However, in the field of lotions, particularly traditional Chinese medicine fumigation and washing therapy, no other medicines are found to be used for treating diabetic neuropathy at present. Based on this, the present invention has been proposed.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides a astragalus pepper vein relaxing lotion, a preparation method and application, and the specific technical scheme is as follows:
a astragalus membranaceus and pepper vein relaxing lotion comprises the following raw materials in parts by mass:
29 to 31 parts of raw astragalus root, 14 to 16 parts of medicinal cyathula root, 29 to 31 parts of clematis root, 19 to 21 parts of prepared aconite root, 9 to 11 parts of asarum herb, 29 to 31 parts of szechuan lovage rhizome, 29 to 31 parts of cassia twig, 19 to 21 parts of Szechuan pepper and 29 to 31 parts of root of red-rooted salvia.
Further improved, the astragalus membranaceus and pepper vein relaxing lotion comprises the following raw materials in parts by mass:
30 parts of raw astragalus, 15 parts of medicinal cyathula root, 30 parts of clematis root, 20 parts of prepared aconite root, 10 parts of asarum herb, 30 parts of szechuan lovage rhizome, 30 parts of cassia twig, 20 parts of pericarpium zanthoxyli and 30 parts of red sage root.
Wherein, the raw astragalus root, the medicinal cyathula root, the clematis root, the prepared aconite root, the asarum herb, the szechuan lovage rhizome, the cassia twig, the pericarpium zanthoxyli and the red sage root are all preferably used as Chinese medicinal decoction pieces; for example, prepared aconite root is preferably used.
The astragalus membranaceus and pepper vein relaxing lotion is an external lotion for vein relaxing, is a Chinese herbal compound, has the characteristics of multiple components, multiple targets and multiple ways of actions, and can treat DPN through multiple ways. In the recipe, raw astragalus root is sweet in taste and warm in nature, enters spleen and lung meridians, is a key herb for tonifying qi, has the effects of tonifying middle-jiao and Qi and raising yang and consolidating exterior, is a monarch drug, and can treat blood stasis blocking syndrome caused by deficiency of qi and blood due to the fact that raw astragalus root has strong tonifying qi and qi circulation and then blood circulation. Radix Cyathulae, rhizoma Ligustici Chuanxiong, ramulus Cinnamomi, fructus Zanthoxyli, and Saviae Miltiorrhizae radix are ministerial drugs, wherein ramulus Cinnamomi is pungent and sweet in taste, warm in nature, and can induce heart, lung and bladder channels, the drugs pungent and sweet in warming, can induce sweat to relieve exterior syndrome, warm and dredge channels, dispel cold to relieve pain, and the compatibility of radix astragali has effects of warming channels and dredging collaterals; danshen is bitter in flavor, slightly cold in nature, and enters heart and liver meridians, it is pungent and warm in nature, dry in nature, has the actions of activating blood, relieving pain, removing stasis and promoting tissue regeneration, activating blood without hurting healthy energy, and resolving hard mass and resolving carbuncles; chuan Xiong is pungent in flavor and warm in nature, enters liver, gall and pericardium meridians, and can activate blood, remove stasis, promote qi circulation and relieve pain; medicinal cyathula root, radix Cyathulae, bitter in taste, sweet and acidic in nature, has the effects of regulating liver and kidney meridians, promoting blood circulation and removing blood stasis, and can be used for descending medicine, wherein Ligusticum wallichii, radix salviae miltiorrhizae and achyranthes root are matched to strengthen the effect of promoting blood circulation and removing blood stasis; chuan Zanthoxylum bungeanum Maxim is pungent in flavor, warm in nature, enters spleen, stomach and kidney meridians, and is pungent in flavor and warm in dryness, and can relieve itching by external application; the adjuvant drugs include radix Aconiti lateralis Preparata and herba asari, wherein radix Aconiti lateralis is pungent, sweet and toxic due to excessive heat, and has effects of inducing heart, kidney and spleen channels, relieving toxicity, nourishing fire and yang, dispelling cold and relieving pain, and relieving pain; asarum is pungent in flavor and warm in nature, and enters lung, kidney and bladder meridians. It is spicy and fragrant, can dispel wind and cold, and has strong pain-relieving actions, both dispelling cold evil in the interior of the kidney meridian and searching for wind-dampness between tibia to relieve pain. The two herbs are combined to assist in warming and expelling cold and relieving pain. The Chinese clematis has pungent and salty taste, enters bladder meridian, is pungent and dispersed to remove flection, can dispel rheumatism of the body and muscle surface, and can also unblock the upper and lower channels and collaterals to relieve pain; the combination of the medicines can achieve the effects of pungent temperature, dredging collaterals, eliminating pathogenic factors, promoting blood circulation and removing blood stasis.
The fumigation and washing therapy of traditional Chinese medicine is a recipe selected by the principle of external treatment, i.e. internal treatment, and the different method of treating ear. By fumigation and washing with traditional Chinese medicine, striae can be developed, so that qi and blood flow can be smooth, and the purpose of preventing and treating diseases can be achieved.
Further improved, the preparation method of the astragalus membranaceus and pepper vein relaxing lotion comprises the following steps:
weighing the raw materials according to the formula amount, soaking in water, decocting, and filtering to obtain filtrate, namely the astragalus membranaceus and pepper vein relaxing lotion.
Further improvement, the raw materials and water are added into the container, and the mass ratio of the raw materials to the water is 1 (10-15).
Further improving, the soaking time is 20-60 min.
Further improving, decocting for 30-90 min for 2 times, mixing decoctions, and filtering.
Further improvement, the application of the astragalus pepper vein relaxing lotion in preparing medicines for preventing or treating diabetic neuropathy, thromboangiitis obliterans, venous embolism of lower limbs, gout, osteoarthritis and rheumatoid arthritis.
The invention has the beneficial effects that:
The invention can be used for treating diabetic neuropathy, thromboangiitis obliterans, venous embolism of lower limbs, gout, osteoarthritis and rheumatoid arthritis by selecting specific medicinal components for proportioning, and has particularly excellent curative effect on the diabetic neuropathy; the invention has reliable curative effect, simple operation, economy and safety.
Drawings
FIG. 1 is a drawing of the ethical review opinion consent of the medical ethical Committee of the first affiliated Hospital of the university of Anhui, chinese medicine.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Example 1
The formula of the astragalus membranaceus and pepper vein relaxing lotion comprises the following components:
30g of raw astragalus, 15g of medicinal cyathula root, 30g of clematis root, 20g of prepared aconite root, 10g of asarum, 30g of szechuan lovage rhizome, 30g of cassia twig, 20g of pericarpium zanthoxyli and 30g of red sage root.
The preparation method comprises the following steps: weighing the raw materials according to the prescription, placing the raw materials into a closed pressure decoction machine, adding 12 times of water (2580 g), soaking for 0.5h, decocting for 3 times and 1h each time, mixing the decoctions, and filtering to obtain filtrate, namely the astragalus membranaceus and pepper vein relaxing lotion.
The using method comprises the following steps: 500ml of astragalus pepper vein relaxing lotion is taken, and a proper amount (such as 2500 ml) of warm water with the temperature of 38-40 ℃ is added according to the foot soaking habit of each person for dilution, and then soaking and washing are carried out.
Example 2
Unlike example 1, the formula of the astragalus pepper vein relaxing lotion is:
29g of raw astragalus, 14g of medicinal cyathula root, 29g of clematis root, 19g of prepared aconite root, 9g of asarum, 29g of szechuan lovage rhizome, 29g of cassia twig, 19g of pericarpium zanthoxyli and 29g of red sage root.
Example 3
Unlike example 1, the formula of the astragalus pepper vein relaxing lotion is:
31g of raw astragalus, 16g of medicinal cyathula root, 31g of clematis root, 21g of prepared aconite root, 11g of asarum, 31g of szechuan lovage rhizome, 31g of cassia twig, 21g of pericarpium zanthoxyli and 31g of red sage root.
Curative effect investigation
70 Patients with diabetic peripheral neuropathy were selected, and the random digital meter method was divided into a control group and a treatment group, each of which was 35. After removal of the shedding cases, 35 cases were observed in the control group and 33 cases were observed in the observation group. Wherein, in 8 men and 27 women in the control group, the average age is 61 years, and the average course of disease is 12 months; treatment groups of 13 men, 20 women, average age 62 years, average course of disease 10 months. Clinically, the lower limbs are symmetrical numbness, pain and other paresthesias and dyskinesias.
Efficacy assessment criteria:
1. the effect is shown: the clinical symptoms of the patients are obviously improved, and the reduction of the clinical score of Toronto is more than or equal to 70 percent.
2. The method is effective: the clinical symptoms of the patients are obviously improved, and the score is reduced by more than or equal to 30 percent after the treatment of the Toronto clinical score.
3. Invalidation: patient clinical symptoms were not relieved, score drop after Toronto clinical score treatment was <30%.
After 68 cases of diabetic peripheral neuropathy patients are treated, the control group has 0 person of significant effect, 21 persons of significant effect and 14 persons of no effect, the treatment group has 0 person of significant effect, 27 persons of significant effect and 6 persons of no effect, the total effective rate is 81.81%, and the total effective rate of the treatment group is quite remarkable.
The specific test procedure is as follows:
The test uses a randomized, controlled clinical trial method.
And (3) randomizing: screening qualified subjects were randomized into groups according to a random number table, and study drug 1:1 was randomized into treatment and control groups to ensure inter-group balance.
Control: the treatment group was astragalus membranaceus vein relaxing lotion + epalrestat tablet + basal treatment, wherein astragalus membranaceus vein relaxing lotion was taken from example 1; the control group is simulated by astragalus pepper vein relaxing lotion, epalrestat tablet and basic treatment. 1 dose of astragalus membranaceus vein relaxing lotion (and placebo) each time, 1 time/day, and external use, 30 minutes of foot bath each time, constant temperature of 38-42 ℃ and soaking depth of 20cm on ankle; epalrestat tablet, 50mg each time, is taken 3 times daily before meals. Basic treatment: and controlling blood sugar. Both groups of patients were treated continuously for 2 weeks, followed regularly.
The test results are shown in tables 1 to 3, and the results show that:
The test group showed significant improvement in TCSS score, MNSI questionnaire score, MNSI physical examination score (p < 0.05), and the treatment group had a preference over the control group (p < 0.05) in terms of nerve conduction velocity, amplitude, and latency of the common sural nerve and sural nerve.
TABLE 1
Note that: a p <0.05, compared to the pretreatment of the same group; b p <0.05, compared to control post-treatment.
TABLE 2
Note that: a p <0.05, compared to the pretreatment of the same group; b p <0.05, compared to control post-treatment.
TABLE 3 Table 3
Note that: a p <0.05, compared to the pretreatment of the same group; b p <0.05, compared to control post-treatment.
It should be noted that the astragalus membranaceus and pepper vein relaxing lotion is in clinical research, and the above test data are all derived from the clinical research; the astragalus membranaceus and pepper vein relaxing lotion disclosed by the invention passes the ethical examination of the ethical committee of medical science of the first affiliated hospital of the university of Anhui traditional Chinese medicine, and can be specifically seen in the ethical examination opinion consent letter of the ethical committee of medical science of the first affiliated hospital of the university of Anhui traditional Chinese medicine of fig. 1.
Typical cases
Case 1
Liu Mou women, 64 years old, found a 1 year increase in blood glucose with numbness and pain of the extremities for 1 month. The patient is detected to have blood sugar rise in 1 year of forebody examination, the fasting blood sugar is 11.1mmol/L, the rest has no obvious uncomfortable symptoms, the patients are not paid attention to and treated, the patients feel numbness of limbs, pain and coldness in the last 1 month, the lower limbs are hypodynamia, the weight is reduced by about 3kg, the self-test blood sugar is fasting 8.1mmol/L, and the postprandial blood sugar is 10.3mmol/L for 2 hours. See below: dry mouth, numbness of limbs, pain, coldness, weakness of the two lower limbs, dizziness, tinnitus, anorexia, poor sleep, dreaminess, frequent urination, dry stool for 2-3 days, dark red tongue, sharp edges and teeth marks, little tongue coating, greasy back and thready and slippery pulse. The astragalus pepper vein relaxing lotion is used for 1 time/day, the epalrestat is used for 50mg each time, 3 times a day for two weeks, the symptoms are obviously improved, the numbness of limbs is eliminated, and the pain and the coolness are improved.
Case 2
Fei Mou women, 68 years old, have blood sugar rise for more than 10 years, have numbness of the lower limbs for 1 year, and are aggravated for more than 3 months. The existing numbness of the two lower limbs is accompanied by cool feeling, the skin is subjected to cold numbness and aggravated cool feeling, and is extremely aversive, and people still need to wear two double-thick socks in summer to relieve severe cases, and the history of 2 diabetes is 10 years old, the blood sugar is poor in control, glycosylated hemoglobin is 8.0%, fasting blood sugar is 10-14 mu mmol/L, and postprandial blood sugar is 18-22 mu mmol/L. In addition to taking hypoglycemic agents, after using astragalus pepper vein relaxing lotion for 2 weeks, the numbness of the two lower limbs is found to be improved with cool feeling.
Case 3
Ma Mou male, 59 years old, found that blood glucose increased for more than 7 years, lower limbs were debilitated, numb and painful for more than 1 month. The patient has the advantages that the lower limbs of the patient are debilitated, the lower limbs and the soles of the patient are cool and numb after long-term running, the patient is stabbed, the patient has no pathological changes in lumbar vertebra after standing and running, the patient has no pathological changes when checking, the patient has both hands cool, the current hypoglycemic scheme is subcutaneous injection before sleeping of insulin glargine 14/15U, the recent fasting blood glucose is controlled to be about 8mmo/L, and the postprandial blood glucose fluctuation for 2h is 11-13 mmoles/L. After the astragalus membranaceus and pepper vein relaxing lotion is used for 2 weeks, the feet are cool and numb, and the pain is even.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (7)
1. The astragalus membranaceus and pepper vein relaxing lotion is characterized by comprising the following raw materials in parts by mass:
29 to 31 parts of raw astragalus root, 14 to 16 parts of medicinal cyathula root, 29 to 31 parts of clematis root, 19 to 21 parts of prepared aconite root, 9 to 11 parts of asarum herb, 29 to 31 parts of szechuan lovage rhizome, 29 to 31 parts of cassia twig, 19 to 21 parts of Szechuan pepper and 29 to 31 parts of root of red-rooted salvia.
2. The astragalus membranaceus and pepper vein relaxing lotion as claimed in claim 1 is characterized by comprising the following raw materials in parts by mass:
30 parts of raw astragalus, 15 parts of medicinal cyathula root, 30 parts of clematis root, 20 parts of prepared aconite root, 10 parts of asarum herb, 30 parts of szechuan lovage rhizome, 30 parts of cassia twig, 20 parts of pericarpium zanthoxyli and 30 parts of red sage root.
3. The method for preparing the astragalus pepper vein relaxing lotion according to claim 1, comprising the following steps:
weighing the raw materials according to the formula amount, soaking in water, decocting, and filtering to obtain filtrate, namely the astragalus membranaceus and pepper vein relaxing lotion.
4. The method for preparing the astragalus pepper vein relaxing lotion according to claim 3, which is characterized in that: the raw materials and water are added into a container, and the mass ratio of the raw materials to the water is 1 (10-15).
5. The method for preparing the astragalus pepper vein relaxing lotion according to claim 3, which is characterized in that: the soaking time is 20-60 min.
6. The method for preparing the astragalus pepper vein relaxing lotion according to claim 3, which is characterized in that: 2 times of decoction at least, wherein each time of decoction is 30-90 min, and the obtained decoction after each time of decoction is combined and filtered.
7. The use of a astragalus pepper vein relaxing lotion as claimed in claim 1, wherein: the astragalus pepper vein relaxing lotion is applied to the preparation of medicines for preventing or treating diabetic neuropathy, thromboangiitis obliterans, venous embolism of lower limbs, gout, osteoarthritis and rheumatoid arthritis.
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