CN101780186B - Medicine for curing brain dysfunction caused by traumatic brain injury - Google Patents
Medicine for curing brain dysfunction caused by traumatic brain injury Download PDFInfo
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Abstract
The invention discloses a medicine for curing brain dysfunction caused by traumatic brain injury, which belongs to the technical field of Chinese medicine, and is mainly prepared from the following two groups of raw material medicine by weight: group I: 2 to 6g of rhizoma ligustici wallichii, 6 to 12g of angelica, 5 to 10g of peach kernel, 3 to 9g of safflower, 6 to 12g of ginseng, 30 to 90g of astragalus, 6 to 9g of earthworm, 6 to 12g of acorus gramineus, 6 to 9g of polygalaceae, 9 to 30g of bidentata, 10 to 30g of acanthopanax, and 3 to 6g of honey-fried licorice root; group II: 2 to 3g of amber or 3 to 6g of wild jujube, 0.5 to 1g of leech, 0.5 to 1g of scorpio, and 3 to 6g of zaocys dhumnade. The medicine of the invention is applicable to the brain dysfunction caused by traumatic brain injury, particularly applicable to patients on which western medicine treatment is ineffective, the curing effect is poor and diseases are not cured after being treated for a long time, so that the effective rate of the February treatment period reaches 65.9 to 86.9 percent, and the diseases do not reoccur. The medicine of the invention is a pure Chinese medicine preparation, is convenient to operate and take.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of brain dysfunction caused by traumatic brain injury, belong to technical field of Chinese medicines.
Background technology
Brain dysfunction caused by traumatic brain injury, comparatively common clinically, be one of medical circle pertinacious disease of being difficult to thoroughly overcome.It is impaired etc. that cerebral trauma can cause that cerebral blood circulation sexual disorders, cerebrospinal fluid circulation disorder, brain cell disorder cause that nerve conduction path blockade, the discharge of axoneure film cause that nervous tissue's irritability changes, brain neuron is undermined reticular formation of brain stem.Can cause feeling of fullness in the head and stuttering puckery, numb limbs and tense tendons of pain, forgetful insomnia, Mental fatigue, visual deterioration, malasia, inappetence, being irritable and getting angry easily, speech or movable ineffective, darkish complexion, tongue with ecchymosis, how heavy arteries and veins is or carefully puckery.Doctor trained in Western medicine is many based on symptomatic treatment, often produces little effect obstinate.Can not fundamentally remove patient's misery, the patient be enjoyed decoct.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation, thereby improve this sick cure rate, remove the hardship of persistent ailment for numerous patients the brain dysfunction caused by traumatic brain injury treating both the principal and secondary aspects of a disease.
According to theory of Chinese medical science, the handicapped etiology and pathogenesis of cerebral trauma hindbrain is that QI and blood is retarded by silt, the brain mansion is lost and supported.Method of treatment is then based on benefiting qi and nourishing blood, nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, invigorating brain and relieving mental uneasiness.For achieving the above object, we use the Chinese medicine theory in motherland's medical treasure-house, carry out determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, the method for the treatment of both the principal and secondary aspects of a disease.
Technical scheme of the present invention is: a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of, it is characterized in that, and mainly make by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 2～6g, Radix Angelicae Sinensis 6～12g, Semen Persicae 5～10g, Flos Carthami 3～9g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g or Semen Ziziphi Spinosae 3～6 grams, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g.
The further technical scheme of the present invention is that this kind is used for the treatment of the handicapped medicine of cerebral trauma hindbrain, it is characterized in that, mainly made by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 2～6g, Radix Angelicae Sinensis 6～12g, Semen Persicae 5～10g, Flos Carthami 3～9g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, the Cortex Eucommiae 10～36g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g or Semen Ziziphi Spinosae 3～6 grams, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g.
The further technical scheme of the present invention can also be that this kind is used for the treatment of the handicapped medicine of cerebral trauma hindbrain, it is characterized in that, mainly made by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 2～6g, Radix Angelicae Sinensis 6～12g, Semen Persicae 5～10g, Flos Carthami 3～9g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g or Semen Ziziphi Spinosae 3～6 grams, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g, Scolopendra 1～2g.
The further technical scheme of the present invention can also be that this kind is used for the treatment of the handicapped medicine of cerebral trauma hindbrain, it is characterized in that, mainly made by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 2～6g, Radix Angelicae Sinensis 6～12g, Semen Persicae 5～10g, Flos Carthami 3～9g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Ramulus Cinnamomi 10～20g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g or Semen Ziziphi Spinosae 3～6 grams, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g.
The further technical scheme of the present invention can also be that this kind is used for the treatment of the handicapped medicine of cerebral trauma hindbrain, it is characterized in that, mainly made by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 2～6g, Radix Angelicae Sinensis 6～12g, Semen Persicae 5～10g, Flos Carthami 3～9g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Radix Dipsaci 10～20g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g or Semen Ziziphi Spinosae 3～6 grams, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g.
The further technical scheme of the present invention can also be that this kind is used for the treatment of the handicapped medicine of cerebral trauma hindbrain, it is characterized in that, mainly made by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 3～10g, Radix Angelicae Sinensis 6～15g, Semen Persicae 5～10g, Flos Carthami 3～10g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Herba Taxilli 20～30g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g or Semen Ziziphi Spinosae 3～6 grams, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g.
The weight of above-mentioned raw materials medicine is the single-dose amount, i.e. patient's dosage every day.
The present invention is made for pure Chinese medicine, and dosage form can be decoction, oral liquid, powder, and the preparation method of oral liquid of the present invention is: II is organized crude drug grind respectively and be smalls, take by weighing above-mentioned II group crude drug in proportion, be mixed, steam after 15 minutes, dry; Get I group crude drug in proportion, fully mix homogeneously was soaked 1 hour, steaming and decocting secondary in steam-jacked kettle, and steaming and decocting 45-55 minute is continued in the back of at every turn boiling; Merge secondary filtrate, quiescent setting 10-12 hour, getting supernatant becomes the ratio decocting and concentrating of 200ml decoction to get decoction in every dose of I group crude drug decocting and concentrating, divide the bottle (one bottle of 200ml) of packing into, every bottle of decoction adds the II group crude drug powder of the above-mentioned potion dose for preparing, and vapor sterilization, labeling are oral liquid of the present invention then.Patient also can make by oneself at home by single dose, and is very convenient.Other dosage form gets final product according to a conventional method.
Instructions of taking: 1 bottle 200 milliliters of every days,, divide secondary to take in 1 hour after meal sooner or later.
Drug function of the present invention: benefiting qi and nourishing blood, nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, invigorating brain and relieving mental uneasiness.Cure mainly: the disordered brain function due to the cerebral trauma has: stuttering puckery, numb limbs and tense tendons of feeling of fullness in the head and pain, forgetful insomnia, Mental fatigue, visual deterioration, malasia, inappetence, being irritable and getting angry easily, speech or movable ineffective, darkish complexion, tongue with ecchymosis, how heavy arteries and veins is or carefully puckery.Be specially adapted to patient that western medicine and medical practitioners is failed to respond to any medical treatment or curative effect is not good enough, cureless.
In the therapeutic process, limbs pain heating appears in the hemiplegic patient of part numb limbs and tense tendons, analgesis in the drug administration process, and this be a normal phenomenon, stagnation of QI and blood may bring about pain, and pain is then obstructed, should adhere to taking medicine, and can't fear the painful medicine that breaks, all that has been achieved is spoiled.In addition, also should advise patient's having regular daily life, transfer cold and heat, preventing cold is in order to avoid the state of an illness repeatedly, for the patient of long-term bed, should encourage patient's polydipsia water, duty to stand up, often blow up a balloon with prevention urinary tract infection, decubital ulcer, hypostatic pneumonia.
The mechanism of action: the traditional Chinese medical science is thought primary disease is that the blood oozing from the body openings or subcuta neous tissue arteries and veins forms congestion outward because wound causes venation impaired, and the brain mansion is lost and supported, and disease gradually reaches Liver and kidney for a long time, sees that then forgetful insomnia, being irritable and getting angry easily, Mental fatigue, visual deterioration, speech are stuttering puckery; " stagnation of QI and blood may bring about pain ", the pain so see feeling of fullness in the head; " pathogen usually intruding into collateral in protracted disease " muscle arteries and veins loses supports, then visible numb limbs and tense tendons or movable ineffective; Darkish complexion, tongue with ecchymosis, hesitant pulse are resembling of stopping in the congestion.So control with benefiting qi and nourishing blood, nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, invigorating brain and relieving mental uneasiness.Blood circulation promoting and blood stasis dispelling such as Rhizoma Chuanxiong, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Hirudo in the side; " the capable then blood of gas is capable " is so with the Radix Astragali, ginseng qi-tonifying; Chinese Angelica blood replonishing, control stasis-breaking drug hematozemia blood trouble; The refreshment of having one's ideas straightened out of Rhizoma Acori Graminei, Radix Polygalae; " Mingyi Bielu " meaning Radix Et Caulis Acanthopanacis Senticosi " the invigorating middle warmer benefit is smart, hard muscles and bones, Qiang Zhiyi ", Compendium of Material Medica are called it and can " be advanced diet, be good for strength, not forget things ", succinum, Radix Et Caulis Acanthopanacis Senticosi energy blood-promoting and mind-easing; " pathogen usually intruding into collateral in protracted disease " is so with insects medicine collateral dredging such as Pheretima, Scorpio, Scolopendra, Zaocys, Hirudos; Radix Achyranthis Bidentatae, the Cortex Eucommiae, Herba Taxilli, Radix Dipsaci, Radix Et Caulis Acanthopanacis Senticosi nourishing the liver and kidney, invigorate blood circulation, Ramulus Cinnamomi antalgic, Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription are held concurrently can QI invigorating.This prescription at the cause of disease, is learnt from other's strong points to offset one's weaknesses, and therapeutical effect is strong, and untoward reaction is few, and is to disordered brain function due to behind the cerebral trauma, real in capturing the good recipe of primary disease.
Pharmacological action:
Radix Ginseng: have promote learning and memory, strengthen hemopoietic, improve immunity, improve hemorheology and antithrombotic, effects such as antioxidation, antiinflammatory.
The Radix Astragali: have and improve the active effect of erythrocyte sodium pump, the active rising of sodium pump can improve erythrocytic morphotropism, increases the picked-up of erythrocyte to aminoacid and glucose, improves or recovers erythrocytic function; The Radix Astragali can improve the cellular energy dysbolismus, and can promote nerve growth, helps the recovery of injured nerve function; The Radix Astragali is improved microcirculation by blood vessel dilating, to the facilitation that establishes of the recovery of paralyzed limbs peripheral nerve function and collateral circulation
Rhizoma Chuanxiong: have anticoagulant and antithrombotic formation, sedation and analgesia, memory reinforcing effect, antioxidation, be suppressed to fibrocyte I, III procollagen type mRNA and express III.
Flos Carthami: Flos Carthami water decoction energy anticoagulant, the effective ingredient carthamin also can anticoagulant, accumulative platelet there is very significantly depolymerisation, and the increase effect with dosage strengthens, and can improve the fibrinous lytic activity of rat, significantly reduce the length and the weight of thrombosis, the formation and development of anti-tampon.
Semen Persicae: the Semen Persicae extracting solution can make cerebrovascular and peripheral blood flow increase, clinical observation also proves: Semen Persicae has effects such as the retardance of the blood flow of improvement, the capable obstacle of blood, can make each internal organs respectively organize functional recovery, especially the expansion of cerebral vascular effect is especially remarkable, the multiple extract of Semen Persicae has antiinflammatory action preferably in addition, its anti-acute transudation is strong, and anti-granulation forms also certain effect.
Radix Angelicae Sinensis: have anticoagulant and antithrombotic and form, cerebrovascular and peripheral blood vessel all there is dilating effect, compatibility Radix Ginseng treatment alzheimer disease has certain curative effect, and ginseng returns decoct that viper quinoline acid damage bilateral Hippocampus CA1 district is caused the effect of having clear improvement of learning and memory in rats obstacle.
Pheretima: contain succinic acid in the Pheretima, it is reported that succinic acid is the maincenter inhibitory transmitter, can prolong the length of one's sleep of pentobarbital sodium, Pheretima has the merit of anticoagulant, antithrombotic, think at present and contain a kind of efficient anticoagulant and fibrinolysis enhancing material in the earthworm decoction, it is not saccharide and protein for the chemical test proof, and may be heat-resisting, alkali proof little peptide of a class or double bond containing chemical compound.
Rhizoma Acori Graminei: have calmness, promote animal muscle power and Chilean effect.
Radix Polygalae: infringement has the certain protection effect to AD rat model ability of learning and memory.The stable effect of the calmness of Radix Polygalae Gu has been used it, and modern pharmacological research is inquired into the wherein sedative activity and the mechanism of polygalasaponin composition, and mechanism of action is dopamine and 5-hydroxytryptamine receptor antagonism in the body of this material of research prompting.
Radix Achyranthis Bidentatae: have memory reinforcing and endurance, gavage 7 days continuously for mice, can obviously improve memory disorder due to the pentobarbital sodium, and can prolong mice load swimming time with Radix Achyranthis Bidentatae decocting liquid.
Radix Et Caulis Acanthopanacis Senticosi: the central nervous system is had dual regulation, have the learning and memory of promotion, enhance immunity, anti-stress effect, " property of medicine opinion " called it and " can be broken by aversion to wind blood ... main blood stasis for many years is at musculus cutaneus ", and it has the hemorheology of improvement, antithrombotic, anticoagulant effect modern study.
Hirudo: give the tame rabbit ear vein injection water trematodiasis water extract-alcohol precipitation liquid of experimental cephalophyma, can reduce the hematoma area of brain section, promote cephalophyma to absorb, reduce brain tissue inflammation's cellular infiltration area, the protection cerebral tissue is beneficial to the recovery of function of nervous system; Oral Hirudo powder or water preparation treatment cerebral hemorrhage intracranial hematoma 48 examples, total effective rate is 91.76%, CT examination confirms that Hirudo can promote cephalophyma to absorb, and paralysis, consciousness and aphasis are restored.
Scorpio: scorpion body and scorpion tail preparation no matter irritate stomach or intravenous injection, all have remarkable analgesic activity to animal skins pain in the skin or Encelialgia.
Radix Glycyrrhizae Preparata: experimental results show that; cerebral ischemia re-pouring can obviously increase rat cerebral tissue's mda content; in this process; peroxidization is enhanced; after giving the composition diammonium glycyrrhizinate in the Radix Glycyrrhizae; diammonium glycyrrhizinate can suppress the generation of malonaldehyde, alleviates the lipid peroxidation of cerebral tissue, and the cranial nerve cell apoptosis is had significant protective effect.
Succinum: succinum is resinous, volatile oil, succooxyabietic acid, succinoabietinolic acid, succinosilvic acid, succinoresinol, succinum Colophonium lipidol, succinic acid etc., experiment confirm, this medicine can prolong the length of one's sleep of pentobarbital sodium, is used for cardiopalmus, insomnia, dreaminess, forgetful more.
Zaocys: modern study thinks that the have some improvement effect Zaocys of blood viscosity of Zaocys has very strong analgesic effect.
Semen Ziziphi Spinosae: Semen Ziziphi Spinosae is rich in fatty oil 32%, wherein contain 8 kinds of fatty acids, part is a unsaturated fatty acid, other composition has betulic acid, betulin, swertisin, Semen Ziziphi Spinosae saponin and ferulic acid, vitamin etc., and contain several amino acids and trace element, what its medicinal material base was paid close attention to is materials such as Semen Ziziphi Spinosae Saponin, flavonoid glycoside, Ziziphi Spinosae polysaccharide.Generally believe that saponin is the effective calm composition of Semen Ziziphi Spinosae, it is a triterpenoid compound, and structurally with Radix Ginseng, the saponin active ingredient of Radix Notoginseng etc. is comparatively approaching, gives birth to, Semen Ziziphi Spinosae (parched) chemical constituent difference is little.Clinical and pharmacological evaluation proves that all Semen Ziziphi Spinosae has significant calmness and syngignoscism and anticonvulsant action.
The Cortex Eucommiae: the intraperitoneal perfusion Cortex Eucommiae extract can obviously be expanded the bore of Mice Auricle blood capillary, and the open number of capillary network is increased, and blood flow is accelerated, and improves the human body microcirculation function, thereby influences body body constitution and resistance against diseases; Laricin (syringin) contained in the Folium Eucommiae is the inhibitor of angiotensin and cAMP, and can increase blood flow volume; The Cortex Eucommiae can improve the activity that body is removed free radical, the blocking-up free radical lock reaction.
Scolopendra: the chemical constituent of Scolopendra mainly contains H-subst and hemolytic protein; Still fatty oil, cholesterol, formic acid etc.Aminoacid has histidine, arginine, lysine, glycine, alanine, glutamic acid etc.Show that according to the study the intravital toxic component of Scolopendra is fine crystallinity toxic protein, similar being in cheese matter and the crystallization of corrosion matter is a kind of narcotic after this toxic protein hydrolysis, and tool anesthesia and analgesia analgesic effect.
Ramulus Cinnamomi: modern pharmacology studies confirm that Ramulus Cinnamomi has tangible analgesia spasmolysis, because of acting on the brain sensory centre, improves the threshold of pain and has analgesic effect, and the contained cinnamic aldehyde of Ramulus Cinnamomi has dilating effect to peripheral blood vessel, strengthens blood circulation.
Herba Taxilli: mouse peritoneal injection Herba Taxilli tincture 2g/kg can suppress mouse diing time excited by the caused mobility of caffeine and that the prolongation leptazol causes, shows that this product has central nervous system's sedation.
Radix Dipsaci: the water extract of Radix Dipsaci has the effect of vitamin antagonist E deficiency disease, its contained vitamin E has the effect of evacuation of pus, hemostasis, analgesia, promotion tissue regeneration to the pain infections, also have defying age with life-saving, improve effects such as learning memory, cholesterol reducing, antitumor.
In view of the patient of brain dysfunction caused by traumatic brain injury exists blood microcirculation obstacle, body free radical scavenging obstacle, the patient exists headache, insomnia, forgetful, play microcirculation improvement, remove free radical so in further technical scheme, add the Cortex Eucommiae, Scolopendra, Ramulus Cinnamomi, Herba Taxilli or Radix Dipsaci, play calmness, analgesia, improve memory, promote effect such as neurological functional recovery.
The invention has the beneficial effects as follows: medicine of the present invention is applicable to the disordered brain function due to the cerebral trauma, is specially adapted to patient that western medicine and medical practitioners is failed to respond to any medical treatment or curative effect is not good enough, cureless, and February, the course of treatment, effective percentage reached 65.9-86.9%, and did not see recurrence.Medicine of the present invention is pure Chinese medicinal preparation, and is easy and simple to handle, taking convenience, and the patient also can make at home.
Further specify its beneficial effect below in conjunction with clinical data and model case.
One, clinical data
1. clinical data: in October, 2002～2009 year October, the disordered brain function patient has carried out clinical verification after Liaocheng City second the People's Hospital is to 91 routine cerebral traumas.The present invention verifies cerebral trauma occiput and mental symptom 50 examples (I group: male 40 examples, women 10 examples), numb limbs and tense tendons and movable ineffective 30 examples (II group: male 22 examples, women 8 examples behind the cerebral trauma, wherein 2 grade of 6 example of muscular strength, 3 grade of 12 example, 4 grade of 8 example, 5 grade of 4 example), have above-mentioned two kinds of situation person's 11 examples (III group: male 8 examples, women 3 examples, wherein 2 grade of 2 example of muscular strength, 3 grade of 4 example, 4 grade of 4 example, 5 grade of 1 example) concurrently.The elder of the course of disease is for 7 years, and the shortest person had a surplus in 1 month.
2, method: after all case diagnosis are clear and definite, be used for the treatment of 1 bottle of medicine oral liquid every day of brain dysfunction caused by traumatic brain injury, divide and take for 2 times with throwing the present invention.This oral liquid can also be by single dose self-control at home, and very convenient patient need not to be in hospital.
3, result:
After I group patient took 30 bottles, head and mental symptom complete obiteration 32 examples alleviated 11 examples.For consolidating curative effect, advise it to obey 30 bottles again, symptom complete obiteration 40 examples, 4 examples take a turn for the better.Cure rate 80.0%, effective percentage 88.0%.Visited 1 year, and do not see recurrence.
After the II group was taken 30 bottles, numb limbs and tense tendons complete obiteration 16 examples alleviated 8 examples; Muscular strength increases person's 5 examples more than 1 grade.For consolidating curative effect, advise it to obey 30 bottles again, numb limbs and tense tendons symptom complete obiteration 22 examples, 4 examples that take a turn for the better, cure rate 73.3%, effective percentage 86.7%; Muscular strength increases person's 20 examples more than 1 grade, total effective rate 66.7%.Visited 1 year, and do not see recurrence.
After the III group was taken 30 bottles, head and mental symptom complete obiteration 3 examples alleviated 5 examples; Numb limbs and tense tendons disappear 3 examples, alleviate 4 examples, muscular strength increases person's 3 examples more than 1 grade.For consolidating curative effect, advise it to obey 30 bottles again, head and mental symptom complete obiteration 7 examples, 2 examples that take a turn for the better, cure rate 63.6%, effective percentage 81.8%; Numb limbs and tense tendons disappear 6 examples, alleviate 3 examples, cure rate 54.5%, total effective rate 81.8%, muscular strength increase person's 7 examples more than 1 grade, total effective rate 63.6%.Visited 1 year, and do not see recurrence.
Two, model case:
Case 1: Liu so-and-so, man, 46 years old, workman.Headache, insomnia, left limb numbness, movable ineffective 2 years.Because of traffic accident causes cerebral trauma, behind the neurosurgery hospitalization, took a turn for the better before 2 years, the back sense left limb numbness, unable of leaving hospital, dizziness headache is forgetfully slept less, and being irritable and getting angry easily is taken treatment cerebrovascular medicine for a long time, and curative effect does not show, and comes institute to go to a doctor on July 6th, 2007.Check: blood pressure 130/85mmHg, mind is clear, speech undercurrent profit, circle such as isocoria, bicker does not have crooked, and it is placed in the middle to loll.4 grades of left lower extremity muscular strengths, muscular tension are normal, and bitterly, hypopselaphesia, the left side pathologic reflex is not drawn.Dimly red tongue has ecchymosis, thin fur, hesitant pulse.With throwing medicine oral liquid of the present invention, take 10 bottles after, dizziness headache subtracts greatly, sleeps obviously and to improve, emotion takes a turn for the better, pain and numbness alleviates to some extent.For consolidating curative effect, behind 10 bottles of clothes, numb limbs and tense tendons disappears, muscular strength increases to some extent, continue to take 30 bottles after Myodynamia recovery normal, all disease knowing are removed.Visited 1 year, and do not see recurrence.
Case 2: hot so-and-so, woman, 57 years old, peasant.Threw from 2 meters eminences before 1 year and cause cerebral trauma, behind the neurosurgery hospitalization, take a turn for the better, left over the right side numb limbs and tense tendons, as the sense of ant row, movable ineffective, slurred speech, dizziness headache, forgetful insomnia, spiritlessness and weakness, tinnitus, lassitude, it is not good to take multiple effect of drugs, comes institute to go to a doctor on April 23rd, 2006.Check: blood pressure 125/80mmHg, refreshing clear, the imperfection motor aphasia, the right side nasolabial fold is shallow, and right avertence lolls.3 grades of right side limbs muscular strengths, the muscular tension height, bitterly, hypopselaphesia, the right side pathologic reflex positive.Tongue secretly has ecchymosis thin fur, deep-thready pulse.Throw medicine oral liquid of the present invention, take 15 bottles after, dizzy, headache alleviates, sleep, memory are improved, spirit takes a turn for the better, after 25 bottles, pain and numbness alleviates, speech is more preceding fluent, tinnitus disappears, muscle power increases to some extent.For consolidating curative effect, advise it to obey 20 bottles again, the right side numb limbs and tense tendons disappears, 4 grades of muscular strengths.Followed up a case by regular visits to 1 year, and do not see recurrence.
The specific embodiment
Embodiment 1:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 12g, Radix Et Caulis Acanthopanacis Senticosi 15g, Herba Taxilli 24g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.
The oral liquid manufacture method is: take by weighing the raw material of above-mentioned weight, fully mix homogeneously was soaked 1 hour, and steaming and decocting secondary in steam-jacked kettle boiled 45-55 minute at every turn; Merge secondary filtrate, quiescent setting 10-12 hour, get after the supernatant decocting and concentrating decoction 200ml, divide the bottle of packing into, vapor sterilization, labeling are oral liquid of the present invention then.Patient also can make by oneself at home by single dose, and is very convenient.Other dosage form gets final product according to a conventional method.
Embodiment 2:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Herba Taxilli 24g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 3:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 9g, Radix Ginseng 12g, Radix Astragali 60g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Herba Taxilli 24g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 4:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 9g, Radix Ginseng 12g, Radix Astragali 90g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Herba Taxilli 24g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 5:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 9g, Radix Ginseng 12g, Radix Astragali 90g, Pheretima 9g, Rhizoma Acori Graminei 12g, Radix Polygalae 12g, Radix Achyranthis Bidentatae 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Herba Taxilli 24g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 6:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 12g, Radix Et Caulis Acanthopanacis Senticosi 15g, Ramulus Cinnamomi 12g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 7:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 12g, Radix Et Caulis Acanthopanacis Senticosi 15g, Radix Dipsaci 12g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 8:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Fructus Alpiniae Oxyphyllae 9g, Radix Achyranthis Bidentatae 12g, Radix Et Caulis Acanthopanacis Senticosi 15g, Radix Dipsaci 12g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 9:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Cortex Eucommiae 24g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 10:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 30g, Radix Et Caulis Acanthopanacis Senticosi 30g, Cortex Eucommiae 36g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 11:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 15g, Radix Et Caulis Acanthopanacis Senticosi 30g, Radix Glycyrrhizae Preparata 6g; II group: succinum 3g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 12:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 15g, Radix Et Caulis Acanthopanacis Senticosi 30g, Radix Glycyrrhizae Preparata 6g; II group: Semen Ziziphi Spinosae 6g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 13:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 15g, Radix Et Caulis Acanthopanacis Senticosi 30g, Radix Glycyrrhizae Preparata 6g; II group: Semen Ziziphi Spinosae 6g, Hirudo 1g, Scorpio 1g, Zaocys 6g.Preparation method is with embodiment 1.
Embodiment 14:
Prescription: I group: Rhizoma Chuanxiong 5g, Radix Angelicae Sinensis 9g, Semen Persicae 6g, Flos Carthami 5g, Radix Ginseng 9g, Radix Astragali 45g, Pheretima 9g, Rhizoma Acori Graminei 9g, Radix Polygalae 9g, Radix Achyranthis Bidentatae 15g, Radix Et Caulis Acanthopanacis Senticosi 30g, Radix Glycyrrhizae Preparata 6g; II group: Semen Ziziphi Spinosae 6g, Hirudo 1g, Scorpio 1g, Zaocys 6g, Scolopendra 1g.Preparation method is with embodiment 1.
Claims (10)
1. one kind is used for the treatment of the handicapped medicine of cerebral trauma hindbrain, it is characterized in that, is mainly made by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 2～6g, Radix Angelicae Sinensis 6～12g, Semen Persicae 5～10g, Flos Carthami 3～9g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g or Semen Ziziphi Spinosae 3～6 grams, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g.
2. a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of as claimed in claim 1 is characterized in that, described II group medicine is selected succinum for use in succinum or Semen Ziziphi Spinosae, and described I group crude drug also has the Cortex Eucommiae 10～36g.
3. a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of as claimed in claim 1 is characterized in that, described II group medicine is selected succinum for use in succinum or Semen Ziziphi Spinosae, and described I group crude drug also has Ramulus Cinnamomi 10～20g.
4. a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of as claimed in claim 1 is characterized in that, described II group medicine is selected succinum for use in succinum or Semen Ziziphi Spinosae, and described I group crude drug also has Radix Dipsaci 10～20g.
5. a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of as claimed in claim 1 is characterized in that, described II group medicine is selected Semen Ziziphi Spinosae for use in succinum or Semen Ziziphi Spinosae, and described II group crude drug also has Scolopendra 1～2g.
6. as any described a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of among the claim 1-5, it is characterized in that described medicine is decoction, oral liquid or powder.
7. a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of as claimed in claim 6 is characterized in that described medicine is an oral liquid.
8. prepare the described method that is used for the treatment of the handicapped oral liquid of cerebral trauma hindbrain of claim 7, may further comprise the steps: II is organized crude drug grind respectively and be smalls, take by weighing above-mentioned II group crude drug in proportion, be mixed, steam after 15 minutes, dry; Get I group crude drug in proportion, fully mix homogeneously was soaked 1 hour, steaming and decocting secondary in steam-jacked kettle, and steaming and decocting 45-55 minute is continued in the back of at every turn boiling; Merge secondary filtrate, quiescent setting 10-12 hour, getting supernatant becomes the ratio decocting and concentrating of 200ml decoction to get decoction in every dose of I group crude drug decocting and concentrating, divide the bottle of packing into, 200ml is one bottle, every bottle of decoction adds the II group crude drug powder of the above-mentioned potion dose for preparing, and carries out vapor sterilization promptly then.
9. one kind is used for the treatment of the handicapped medicine of cerebral trauma hindbrain, it is characterized in that, is mainly made by two groups of crude drug of following weight:
I group: Rhizoma Chuanxiong 3～10g, Radix Angelicae Sinensis 6～15g, Semen Persicae 5～10g, Flos Carthami 3～10g, Radix Ginseng 6～12g, the Radix Astragali 30～90g, Pheretima 6～9g, Rhizoma Acori Graminei 6～12g, Radix Polygalae 6～9g, Radix Achyranthis Bidentatae 9～30g, Radix Et Caulis Acanthopanacis Senticosi 10～30g, Herba Taxilli 20～30g, Radix Glycyrrhizae Preparata 3～6g;
II group: succinum 2～3g, Hirudo 0.5～1g, Scorpio 0.5～1g, Zaocys 3～6g.
10. a kind of handicapped medicine of cerebral trauma hindbrain that is used for the treatment of as claimed in claim 9 is characterized in that described medicine is decoction, oral liquid or powder.
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| CN102441080A (en) * | 2010-10-09 | 2012-05-09 | 浙江大学医学院附属第二医院 | Traditional Chinese medicinal composition (compound safflower drink) for treating cerebral trauma and preparation method thereof |
| CN103816456B (en) * | 2014-03-05 | 2016-04-13 | 李树志 | The pharmaceutical composition for the treatment of cerebral trauma sequela |
| CN104162134A (en) * | 2014-08-20 | 2014-11-26 | 泰山医学院 | Traditional Chinese medicine for treating cerebral traumas |
| CN104721594B (en) * | 2015-04-07 | 2015-11-04 | 赵克俊 | A kind of Chinese medicine for the treatment of cerebral trauma reaction syndrome |
| CN105194069A (en) * | 2015-10-26 | 2015-12-30 | 济南新时代医药科技有限公司 | Traditional Chinese medicine composition for treating numbness of the limbs after brain trauma surgery |
| CN105770501A (en) * | 2016-05-18 | 2016-07-20 | 高福源 | Traditional Chinese medicine capsule for treating post-traumatic brain syndrome and preparation method of traditional Chinese medicine capsule |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1943673A (en) * | 2005-10-09 | 2007-04-11 | 林朝文 | Sedation brain refreshing liquid |
| CN101129972A (en) * | 2006-08-21 | 2008-02-27 | 杨文龙 | Traditional Chinese medicine composition, preparation method and use of the same |
| CN100372564C (en) * | 2003-12-05 | 2008-03-05 | 相寿长 | Medicine for preventing and treating brain traumatic reaction syndrome |
| CN101491646A (en) * | 2009-03-03 | 2009-07-29 | 沙松华 | Traditional Chinese medicine preparation for neurologic impairment due to craniocerebral trauma and post-operation and preparation method thereof |
-
2010
- 2010-03-29 CN CN2010101343335A patent/CN101780186B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN100372564C (en) * | 2003-12-05 | 2008-03-05 | 相寿长 | Medicine for preventing and treating brain traumatic reaction syndrome |
| CN1943673A (en) * | 2005-10-09 | 2007-04-11 | 林朝文 | Sedation brain refreshing liquid |
| CN101129972A (en) * | 2006-08-21 | 2008-02-27 | 杨文龙 | Traditional Chinese medicine composition, preparation method and use of the same |
| CN101491646A (en) * | 2009-03-03 | 2009-07-29 | 沙松华 | Traditional Chinese medicine preparation for neurologic impairment due to craniocerebral trauma and post-operation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨鸿飞 ,王琳.中西医结合治疗脑外伤后症候群46例临床观察.<中医药信息>.2009, |
| 杨鸿飞,王琳.中西医结合治疗脑外伤后症候群46例临床观察.<中医药信息>.2009, * |
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