CN102441080A - Traditional Chinese medicinal composition (compound safflower drink) for treating cerebral trauma and preparation method thereof - Google Patents
Traditional Chinese medicinal composition (compound safflower drink) for treating cerebral trauma and preparation method thereof Download PDFInfo
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- CN102441080A CN102441080A CN2010105013226A CN201010501322A CN102441080A CN 102441080 A CN102441080 A CN 102441080A CN 2010105013226 A CN2010105013226 A CN 2010105013226A CN 201010501322 A CN201010501322 A CN 201010501322A CN 102441080 A CN102441080 A CN 102441080A
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Abstract
The invention discloses a traditional Chinese medicinal composition (a compound safflower drink) for treating the cerebral trauma and a preparation method thereof. The traditional Chinese medicinal composition disclosed in the invention is a preparation which comprises: a main active component water extract from Crocus sativus, Ligusticum wallichii, Acorus gramineus, Eucommia ulmoides and prepared rehmannia root; and a pharmaceutic adjuvant. The preparation which has a clear curative effect on patients suffering from the cerebral trauma has unique advantages on the treatment of the secondary brain damage.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition (compound safflower drink) and method for preparing of treating brain trauma.
Background technology
Brain trauma (Traumatic brain injury; TBI), (Severe traumatic braininjury STBI) is the dead most important cause of disease of human wound to especially heavy craniocerebral trauma; Be the serious threat of human health, so it has become the emphasis and the difficult point of neurosurgery area research.How the treatment doctor trained in Western medicine of brain trauma need adopt oxygen supply, dehydration, hormone, calcium antagonist, control infection, anti symptom treatment, nutritional support, keep measure Comprehensive Treatments such as water-electrolyte balance.But depending merely on western medical treatment often has side effects; As being important treatment measure with mannitol dehydration intracranial pressure when lowering cerebral edema; But repeated multiple times can cause significantly increasing of blood viscosity after using mannitol; Produce " rebound phenomenon ", even can increase the weight of vasogenic brain edema, and western medical treatment is to complication unsatisfactory curative effects such as brain secondary lesions.Therefore, explore the combined therapy of Chinese and Western medicine and positive effect is arranged to alleviate complication such as cerebral edema " knock-on " and brain secondary lesion.
Go deep into gradually along with what brain trauma pathogenesis, wound back pathophysiological change and Therapeutic Method were studied, people expand the understanding of brain trauma greatly, and wherein brain trauma and cytokine relation are just becoming the hot issue that scholars pay close attention to.
Cytokine is as inflammatory mediator important in the body; Participate in multiple pathological process; Multiple pathophysiological change behind the STBI; Especially systemic inflammatory response syndrome (Systemic inflanatory response syndrome, SIRS) and multiple organ dysfunction (Multiple organ failure MODS) waits the generation of severe complication relevant with a large amount of secretions of inflammatory cytokine.
Patients with sevious craniocerebral injury is hindered the back body's immunity and is usually got muddled, and inflammatory reaction after the wound occurs, and body produces a large amount of cytokines.The release of cytokine is a kind of defense reaction of body; Help removing the reparation of body tissue after foreign body in vivo and the wound; But the release of cytokine too fierceness can cause that body capillary endothelial cell damage, capillary permeability increase, histiocyte is impaired; And then cause cerebral tissue and hetero-organization organ generation grievous injury thereof, and can cause MODS away from former focus.Interleukin 8 in these cytokines (IL-8), interleukin-18 (IL-18), intercellular adhesion molecule-1 (ICAM-1) etc. plays an important role.IL-8 has participated in the encephaloclastic generation of Secondary cases as a kind of important neutrophilic chemotactic factor.IL-18 is the important multiple-effect ability pro-inflammatory cytokine of of discovered in recent years, and participation body inflammatory and immunoreation, ICAM-1 are important inflammatory mediator of body and inflammation regulatory factor.Therefore, reducing TBI cells in vivo factor level, regulation and control inflammatory reaction effectively, block its development, is concurrent MODS after the control craniocerebral injury, reduces case fatality rate, improves the key of prognosis.The present invention finds that compound safflower drink serum IL-8, IL-18, ICAM-1 after giving the brain trauma rat can suppress brain trauma after 3-4 days of this prescription increase, and have opened up the useful approach of Chinese medicine treatment brain trauma.
Compound safflower drink " TONGQIAOHUOXUE Decoction " in famous doctor family of Qing Dynasty Wang Qingren errors in Medicine Corrected develops; It is Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Moschus, Fructus Jujubae, fresh ginger, old Herba Alii fistulosi that the TONGQIAOHUOXUE Decoction medicine is formed; Compound safflower drink of the present invention is inherited sensible thought of invigorating blood circulation, and is Stigma Croci but be prone to Flos Carthami, and Rhizoma Acori Graminei is for Moschus; Hirudo is for Radix Paeoniae Rubra, Semen Persicae; Abandoning Fructus Jujubae, fresh ginger, old Herba Alii fistulosi, join the Cortex Eucommiae, the new side of Radix Rehmanniae Preparata composition, is Stigma Croci, Rhizoma Chuanxiong, Rhizoma Acori Graminei, the Cortex Eucommiae, Radix Rehmanniae Preparata, Hirudo so compound safflower of the present invention drink medicine is formed.The Stigma Croci sweet in the mouth is cold in nature in the side has a stronger blood circulation promoting and blood stasis dispelling effect, has the merit of removing pathogenic heat from blood and toxic substance from the body heresy again concurrently, Rhizoma Chuanxiong acrid in the mouth, warm in nature, nontoxic; Xin Xiang walks to scurry, main " apoplexy is gone into brain, headache, arthralgia due to cold spasm "; Merit is apt to blood-activating and qi-promoting, and wind-expelling pain-stopping, ancient Chinese medicine doctor are controlled the key medicine of headache.Effective ingredient in Stigma Croci and the Rhizoma Chuanxiong has the function of microcirculation improvement, blood pressure lowering.Can increase microcirculatory blood supply through analgesia, improve cerebral tissue, promote absorption of hematoma, reduce intracranial pressure, improve brain function anoxybiotic tolerance.The Rhizoma Acori Graminei causing resuscitation with aromatic drugs, Hirudo is bitter saltyly to return Liver Channel removing blood stasis with potent drugs blood and not to hinder fresh blood, and the removing obstruction in the collateral to relieve pain effect is arranged, and the Cortex Eucommiae, Radix Rehmanniae Preparata the kidney invigorating are given birth to marrow and are supported brain.All medicines share and can make just that blood stasis is dispelled, pathogenic heat clear, brains are mended, thereby have invigorating blood circulation, have one's ideas straightened out, purge heat, the merit of the kidney invigorating.About the water extract of writing out a prescription with this is that the oral formulations treatment brain trauma that main active ingredient and pharmaceutic adjuvant are formed does not still have bibliographical information.
The present inventor finds to have the cerebral edema of reduction, suppresses behind the brain trauma that IL-18, IL-8, ICAM-1 increase in the serum this side being treated in the research of animal brain wound, improves the brain injury symptom, thereby accomplished the present invention.
Summary of the invention
Technical problem to be solved by this invention is to remedy the deficiency of existing western medicine brain trauma; Provide a kind of and suffer from a deficiency of the kidney for blood stasis that to have curative effect comprehensive for the brain trauma patient of key excess syndrome of stroke; Low toxicity, variable side effect with Western medicine promotes the ideal Chinese medicine composition that wound is recovered.
The Chinese medicine composition of treatment brain trauma disclosed by the invention is with Stigma Croci, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Radix Rehmanniae Preparata, the Cortex Eucommiae, the Hirudo water extract oral formulations that to serve as main active ingredient process with the pharmaceutic adjuvant composition, is good with oral liquid.
The crude drug of respectively distinguishing the flavor of in 1000 preparation units of the present invention is by weight: Stigma Croci 10-20g, Rhizoma Chuanxiong 120-240g, Rhizoma Acori Graminei 100-200g, Hirudo 30-80g, Cortex Eucommiae 120-240g, Radix Rehmanniae Preparata 120-240g.
Oral formulations of the present invention is meant medically acceptable various peroral dosage forms, comprises oral liquid, granule, tablet, capsule etc.
Pharmaceutic adjuvant of the present invention is the various adjuvants that adopted in the conventional formulation.
Another technical problem to be solved by this invention is to provide the method for preparing of above-mentioned Chinese medicine composition.
The method for preparing of the Chinese medicine composition of treatment brain trauma disclosed by the invention comprises the following steps:
Above Six-element, the decocte with water secondary, each 1 hour, collecting decoction filtered; To be concentrated into relative density be 1.1-1.15 (80 ℃) to filtrating, puts coldly, adds ethanol and make and contain the alcohol amount and reach 60%, stirs, and left standstill 24 hours; Filter, filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.15-1.2 (80 ℃), adds correctives, adds water to 1000 milliliters, stirs; Leave standstill, filter, fill, sterilization (120 ℃ 30min) promptly get.
Technical problem to be solved by this invention is to disclose the application of above-mentioned Chinese medicine composition in treatment brain trauma medicine.
Present inventor's zoopery proves the 6 flavor medicine compatibilities of Stigma Croci, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Radix Rehmanniae Preparata, the Cortex Eucommiae, Hirudo and adopts extraction process of the present invention to have the IL-8 of inhibition, IL-18, ICAM-1 increase, reduce cerebral edema, improve the neurologic impairment symptom, and is superior to the TONGQIAOHUOXUE Decoction of Wang Qingren.
Be applicable to the dialectical blood stasis key excess syndrome of stroke brain trauma patient that suffers from a deficiency of the kidney that is by the Chinese medicine of the present invention preparation.Stigma Croci, Rhizoma Chuanxiong, Hirudo blood circulation promoting and blood stasis dispelling are monarch drug and Rhizoma Chuanxiong promoting flow of QI and blood in the prescription of the present invention, inducting the medicines into affected channel, and Radix Rehmanniae Preparata, Cortex Eucommiae the kidney invigorating are auxilliary, assistant makes the Rhizoma Acori Graminei refreshment of having one's ideas straightened out; All medicines share, and play the kidney invigorating blood stasis dispelling altogether, the merit of consciousness-restoring and orifice-opening; Blood stasis must be dispelled, hemorrhage must ending, the brain key must be opened; So clinical all diseases can be healed, and process the oral liquid medication conveniently, but for brain trauma comatose patient nasal feeding administration.
The specific embodiment
Following embodiment is used to further specify the present invention, but does not mean that any restriction of the present invention.
Embodiment 1: different prescriptions of Chinese medicine extracts are to the influence (rat) of craniocerebral injury
Test objective: adopt the freely falling body punch method to make rat craniocerebral injury model, observe the influence of the extract that obtains by different prescriptions of Chinese medicine to craniocerebral injury.
1, method
1.1 prepared by the reagent thing
Prescription 1: Stigma Croci 10g, Rhizoma Chuanxiong 120g, Rhizoma Acori Graminei 100g, Hirudo 30g, Cortex Eucommiae 120g, Radix Rehmanniae Preparata 120g.
Method for making: above Six-element, the decocte with water secondary, each 1 hour, collecting decoction filtered; To be concentrated into relative density be 1.1-1.15 (80 ℃) to filtrating, puts coldly, adds ethanol and make and contain the alcohol amount and reach 60%, stirs, and left standstill 24 hours; Filter, filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.15-1.2 (80 ℃), adds correctives, adds water to 1000 milliliters, stirs; Leave standstill, filter, fill, sterilization (120 ℃ 30min) promptly get.
Prescription 2: TONGQIAOHUOXUE Decoction (Wang Qingren side): Stigma Croci 10g, Rhizoma Chuanxiong 40g, Radix Paeoniae Rubra 40 grams, Semen Persicae 120 grams, Moschus 0.1 gram, Fructus Jujubae 20 grams, fresh ginger 90 grams, old Herba Alii fistulosi 30 grams.
Method for making: above Moschus seven flavors that remove, the decocte with water secondary, each 1 hour, collecting decoction filtered; To be concentrated into relative density be 1.1-1.15 (80 ℃) to filtrating, puts coldly, adds ethanol and make and contain the alcohol amount and reach 60%, stirs; Left standstill 24 hours, and filtered, filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.15-1.2 (80 ℃), adds with Chinese liquor dissolving and filterable Moschus solution; Add water to 1000 milliliters, stir, leave standstill, filtration sterilization (0.22um) promptly gets.
1.2 divide into groups and administration: the animal that modeling is successful is divided into 4 groups at random; Be that model group, blank group, prescription 1 treatment group (2.0g/kg), prescription 2 treatment groups (2.0g/kg) are through irritating stomach tube filling clothes; Twice of every day (every rat 1ml/100g body weight), successive administration 3 days.After administration in the 3rd day 3 hours, sacrificed by decapitation was got brain, got 12h fasting before the brain, freely drank water.
1.3 animal model: model group adopts improved Feeney legal system to make the craniocerebral injury model with the treatment treated animal; Promptly press freely falling body principle preparation one and hit device, hammer quality 40g freely falls from the 25cm eminence; Impact lance, cause right side parietal cortex limitation contusion and laceration of brain.
1.4 observation index and detection method: animal sacrificed by decapitation; Get brain and whole blood; Brain is cut into left and right sides two halves from sagittal suture, damage side brain, claim weight in wet base with electronic analytical balance after; Place and claim its dry weight in 100 ℃ of thermostatic drying chambers behind the 24h, claim to calculate brain water content with the Elliot formula after the dry weight: brain water content (%)=(weight in wet base-dry weight)/weight in wet base x100%.The blood preparation separation of serum adopts kit measurement IL-8, and IL-18, ICAM-1, test kit are available from Wuhan doctor's moral company, and These parameters is measured by its mensuration test kit description and undertaken.
2, result
See table 1.
The different prescriptions of Chinese medicine of table 1 are to the influence of rat craniocerebral injury
Annotate:
*P＜0.05,
*P＜0.01 vs model;
#P＜0.05 vs writes out a prescription 2 groups
3, conclusion
1 extract of writing out a prescription has the inflammatory factor of reduction, alleviates the cerebral edema effect, and is superior to writing out a prescription 2.
Embodiment 2: different prescriptions of Chinese medicine are to the hemorrhage influence of rat brain
Test objective: adopt the collagenase intracerebral injection to make the rat cerebral hemorrhage mold, observe the influence of the extract that obtains by different prescriptions of Chinese medicine to the behavior of cerebral hemorrhage hemiplegia.
1, method
1.1 prepared by the reagent thing
Prescription 1: with embodiment 1.
Method for making: with embodiment 1.
Prescription 2: with embodiment 1
Method for making: with embodiment 1.
1.2 divide into groups and administration: the animal that modeling is successful is divided into 4 groups at random; Be that model group, blank group, prescription 1 treatment group (2.0g/kg), prescription 2 treatment groups (2.0g/kg) are through irritating stomach tube filling clothes; Twice of every day (every rat 1ml/100g body weight), successive administration 4 days.After administration in the 4th day 3 hours, observe animal nerve functional impairment state.
1.3 animal model: after model group adopted chloral hydrate anesthesia with the treatment treated animal, sagittal was cut head skin, exposes skull; With the bregma is the center, and 0.2mm is other to the right backward opens 2.9mm and hole in skull surface with dental burr, with microsyringe along the vertical insertion cerebral tissue of boring; Dark about 6mm, slowly injection contains the normal saline 1.2ul of 1u/ul collagenase, slowly goes out pin behind let the acupuncture needle remain at a certain point the 8min; With the boring on the dentistry cement seal skull, skin suture.
1.4 observation index and detection method: observe the classification of animal nerve functional impairment with reference to the standard of formulations such as Bederson:
The I level does not have obvious obstacle; The II level is mentioned the Mus tail and is made a Mus sagging position, and the Ipsilateral forelimb reclaims flexing in the front, and the forelimb of normal side stretches; The III level knocks into the back; The IV level knocks into the back and hemiplegia side lower limb length is dragged, and eye secretion is many, and eyelid is fuzzy; The V level, astasia, swing to strong side can not from.
2, result
See table 2.
The different prescriptions of Chinese medicine of table 2 are to the fractionated influence of the hemorrhage neurologic impairment of rat brain
Annotate:
*P＜0.05,
*P＜0.01 vs model;
#P＜0.05 vs writes out a prescription 2 groups
3, conclusion
1 extract of writing out a prescription is write out a prescription 2 big to the fractionated improvement degree of rat nerves functional impairment.
Embodiment 3: the granule preparation
The Six-element prepared slices of Chinese crude drugs, decocte with water secondary, each 1 hour, collecting decoction; Filter, it is 1.1-1.15 (80 ℃) that filtrating is concentrated into relative density, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 60%; Stir, left standstill 24 hours, filter; Filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.10-1.15 (80 ℃), and spray drying (170 ℃ of EATs) gets xeraphium; Get above-mentioned xeraphium 500g, sucrose 150g, dextrin 100g mix homogeneously, make wetting agent with an amount of 95% ethanol, wet granulation sieves, oven dry, and 6g/ bag granule is processed in packing.
Embodiment 4: preparation tablets
Obtain exsiccant extract with embodiment 3 with quadrat method, add 10% cross-linking sodium carboxymethyl cellulose, 20% microcrystalline Cellulose, wet granulation, oven dry adds an amount of magnesium stearate and mixes, and is pressed into tablet.
Embodiment 5: the capsule preparation
Obtain exsiccant extract with embodiment 3 with quadrat method, add 15% microcrystalline Cellulose, 3% micropowder silica gel is made wetting agent with an amount of 90% ethanol, and wet granulation sieves, and oven dry adds an amount of magnesium stearate, and mix homogeneously is processed hard capsule.
Claims (5)
1. a Chinese medicine composition is made up of the extract and the pharmaceutic adjuvant of Stigma Croci, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Hirudo, the Cortex Eucommiae, Radix Rehmanniae Preparata.
2. Chinese medicine composition as claimed in claim 1, the crude drug that it is characterized in that respectively distinguishing the flavor of in 1000 preparation units is by weight: Stigma Croci 10-20g, Rhizoma Chuanxiong 120-240g, Rhizoma Acori Graminei 100-200g, Hirudo 30-80g, Cortex Eucommiae 120-240g, Radix Rehmanniae Preparata 120-240g.
3. the oral liquid that is prepared from the described Chinese medicine composition of claim 1.
4. prepare the method for Chinese medicine composition as claimed in claim 1, comprise the following steps:
Above Six-element, the decocte with water secondary, each 1 hour, collecting decoction filtered; To be concentrated into relative density be 1.1-1.15 (80 ℃) to filtrating, puts coldly, adds ethanol and make and contain the alcohol amount and reach 60%, stirs, and left standstill 24 hours; Filter, filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.15-1.2 (80 ℃), adds correctives, adds water to 1000 milliliters, stirs; Leave standstill, filter, fill, sterilization (120 ℃ 30min) promptly get.
5. the application of Chinese medicine composition as claimed in claim 1 in preparation treatment brain trauma medicine.
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Application publication date: 20120509 |