CN101264302A - Application of Chinese medicinal composition in preparing medicaments for treating menoxenia and menorrhalgia - Google Patents
Application of Chinese medicinal composition in preparing medicaments for treating menoxenia and menorrhalgia Download PDFInfo
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Abstract
The invention relates to an application of a known Chinese herbal medicine composition to the preparation of a medicine for curing irregular menstruation and dysmenorrheal. The medicine composition comprises the components with the following weight proportion: angelica sinensis 32.04%, rhizoma ligustici wallichii 12.02%, radix glycyrrhizae (baked) 2.00%, peach kernel 3.21%, dried ginger (carbon) 2.00%, leonurus japonicus 40.05%, safflower 2.00%, paniculate swallowwort 6.68%. The materials are made into capsules, tablets, grains and concentrated pills. The Chinese herbal medicine composition is applied to the preparation of medicine for curing irregular menstruation and dysmenorrheal with obvious effects and high cure rate.
Description
One, technical field
The present invention relates to field of medicaments, be specifically related to the application of a kind of known Chinese medicine composition in preparation treatment menoxenia and dysmenorrhea medicine.
Two, background technology
Menstruation is woman's a normal physiological phenomena." element ask true day of ancient times opinion " says " two or seven menarches of woman, conception vessel is logical, the taichong channel Sheng, menses one at present." traditional Chinese medical science thinks that " blood stored in the liver ", " CHONG meridian being the blood pool ", women are normal the eumenorrhea because dash wantonly two arteries and veins, the liver function is normal.Liver and kidney is homology again, bright Zhang Jiebin say " kidney qi be menses also." so women's menstruation has substantial connection with Liver and kidney again.If disharmony of Chong and Conception Channels, the stagnation of liver-QI of suffering from a deficiency of the kidney can not store blood, then can cause menoxenia, also can cause dysmenorrhea.
Menoxenia is a kind of common disease of women, the change in menstrual cycle characteristics that the general reference a variety of causes causes, comprise shifting to an earlier date of age of menarche, delay, cycle, menstrual period and through the variation of amount, the concrete manifestation form has preceeded menorrhea, delayed menstrual cycle, irregular menstrual period, menorrhagia, hypomenorrhea, amenorrhea, metrorrhagia, disorder or amount too much or measure very few etc.Also have the change of some menstrual cycle in addition, comprise treat through the time long etc.Having is exactly to be accompanied by menoxenia and the some diseases that takes place again, such as menalgia, or is accompanied by the organic pathological changes of pelvic cavity." gynecological beautiful chi " cloud: " through feeling as scheduled, if when coming or before or after, more or less, or months 23 to, or the several months one to, be all uncomfortable ".Menoxenia belongs to that a basis is sick, and it can cause numerous disease, such as causes infertilely, causes tumor of pelvic cavity or the like.It seems that from many aspects the treatment of menoxenia should be paid attention to.
The women is before and after menstrual period or menstrual period occur lower abdomen and waist and sacrum pain, claims dysmenorrhea.Dysmenorrhea can be divided into two kinds of primary dysmenorrhea and secondary dysmenorrheas.Primary dysmenorrhea does not have organic disease, discharges relevant with autonomic nervous dysfunction and prostaglandin.Secondary dysmenorrhea then be owing to operation, childbirth, miscarriage, menstrual period reason such as strenuous exercise cause the pathological changes such as inflammation, adhesion, endometriosis of female sex organ to cause.Dysmenorrhea is common gynecological disease and frequently-occurring disease.The symptom that occurs before and after menstrual period or menstrual period, as the periodicity hypogastralgia, pain connects waist sacrum, perineum, anus, femoribus internus, often with pale complexion, dripping cold sweat, extremity are fainted contrary, nausea and vomiting, even shock, severe patient even can have influence on work and life.
At present, western medicine menoxenia and dysmenorrhea still do not have medicine preferably, remove and use some Anti-Ten beyond the region of objective existences to the ill, also adopt incretotherapy, cervix dilating method or the like.Wherein sedation and analgesia agent symptomatic treatment rather than radical cure, incretotherapy maybe can suppress ovulation, and the application of hormone can be disturbed the physiological period of menstruation, may be unfavorable to the married person of not educating, and the cervical extension art only can be used for the married.Its side effect is obvious, and the patient is difficult to accept.Aspect Chinese patent medicine, HUAHONG PIAN, FUYANJING JIAONANG, NVJIN WAN, TONGJINGBAO KELI, the scorching capsule of health woman and FUKE ZAIZAO WAN etc. are arranged on the market, these medicines all have his own strong points, take effect slowly but all exist, curative effect is not remarkable, treats not thoroughly, and perhaps side effect is bigger, cause shortcomings such as obstinate, clinical effectiveness is all unsatisfactory.
Given this, develop a kind of instant effect, side effect is little, is used for systematically treating the medicine of female irregular menstruation and dysmenorrhea, is very necessary.
A kind of known Chinese medicine composition involved in the present invention is recorded in the 15th the 80th page of Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ", standard code WS
3-B-2890-98 is the medicine of existing national standard.The whole nation has 29 tame pharmaceutical factories and produces imitation medicine, wherein two specifications of the same dosage form of Shaanxi Mo Meide pharmaceutical Co. Ltd SEPARATE APPLICATION at present.The function of primary standard with cure mainly for: invigorate blood circulation, blood stasis dispelling, pain relieving.Be used for disease that postpartum lochia can't go, few abdomen pain also can be tried out the colporrhagia that causes, menorrhagia after being fitted with a contraceptive ring.
Chinese medicine composition of the present invention is with when being classified as monarch drug, and Rhizoma Chuanxiong is a ministerial drug, and Radix Angelicae Sinensis be gynecological's key medicine since ancient times, says as " not record ": " filling in except that objective blood is interior "." bright greatly ": " broken stagnant blood is if look at Li ".Shi Zhen: " enriching blood " with blood.The Chinese angelica blood supplementing regulating menstruation, promoting blood circulation and stopping pain is disorders of blood good medicine, can make blood capable vigorous, promotes developing womb, to young uterine hypoplasia person, that uses is more suitable; Modern pharmacology shows that ferulic acid has spasmolysis in the Radix Angelicae Sinensis, and Radix Angelicae Sinensis volatile oil is to rabbit, Cavia porcellus, the Canis familiaris L. uterine smooth muscle has dual regulation, with the uterine function state substantial connection is arranged, scalable uterine smooth muscle contraction state is removed spasm and is reached the menstruction regulating and pain relieving effect.Its contained cyclobutenyl acyl lactone and ligustilide all are cholinolytic (spasmolytic) active ingredient, and the ligustilide effect is stronger.The Rhizoma Chuanxiong blood-activating and qi-promoting is walked and is not kept, and is gas medicine in the blood, and the ligustrazine in the Rhizoma Chuanxiong can be removed the Golden Hamster folder body capsule fine motion vein that norepinephrine causes and the spasm of blood capillary, and the blood flow that slows down is accelerated, and blood flow increases.Rhizoma Chuanxiong alkaloid and cnidium lactone have spasmolysis; Rhizoma Chuanxiong has " removing blood stasis with potent drugs holds, and promoting blood circulation is separated stagnation of QI, by pain, stimulates the menstrual flow by blood " effect (" book on Chinese herbal medicine just "); " bright greatly " said: " broken stagnated blood is supported fresh blood ... repercussive blood ", " pearl sac " said: " the up head, the descending sea of blood ".Adapted in blood circulation promoting recipe can strengthen the effect of promoting the circulation of blood dissipating blood stasis.The modern pharmacology explanation, Rhizoma Chuanxiong tool significant analgesia role, Rhizoma Chuanxiong alkaloid and cnidium lactone all have spasmolysis, and ligustilide is the Main Ingredients and Appearance of spasmolytic.Cyclobutenyl vinegar lactone and butyl lactone are the Main Ingredients and Appearances of spasmolytic.Cyclobutenyl wine lactone and butyl wine lactone have very strong inhibition uterine contraction effect.Return rhizome of chuanxiong to share hot temperature promoting flow of QI and blood, the menoxenia and the dysmenorrhea of the stagnant hematogenous blockage of all cold all can be used.
The applicant is through in recent years clinical and experimental study, find that Chinese medicine composition of the present invention has the effect of the unmarried women of treatment or married female irregular menstruation and dysmenorrhea, and so far, do not find that Chinese medicine composition of the present invention can treat the experimentation report and the clinical research report of menoxenia and dysmenorrhea.
Summary of the invention
The object of the invention is to provide the application of a kind of known Chinese medicine composition in preparation treatment menoxenia and dysmenorrhea medicine, this Chinese medicine composition is a pure Chinese medicinal preparation, its prescription rationally can be used for the various symptoms that unmarried women or married female irregular menstruation and dysmenorrhea cause.
The application of a kind of Chinese medicine composition of the present invention in preparation treatment menoxenia and dysmenorrhea medicine, the composition of described a kind of Chinese medicine composition and weight proportion are:
Radix Angelicae Sinensis 32.04% Rhizoma Chuanxiong, 12.02% Radix Glycyrrhizae (processing) 2.00%
Semen Persicae 3.21% Rhizoma Zingiberis (charcoal) 2.00% Herba Leonuri 40.05%
Flos Carthami 2.00% Radix Cynanchi Paniculati 6.68%.
The application of a kind of Chinese medicine composition of the present invention in preparation treatment menoxenia and dysmenorrhea medicine, menstrual cycle, menstrual period that described menoxenia can cause for a variety of causes or the various significant discomfort symptoms that change and follow appearance through amount, comprise that preceeded menorrhea, delayed menstrual cycle, menstruation irregularly successively, menostaxis, metrorrhagia such as hypomenorrhea, menorrhagia.Described dysmenorrhea can periodically hypogastralgia occur in menstrual period or its front and back for the women that a variety of causes causes, comprises primary dysmenorrhea and/or secondary dysmenorrhea.
The application of a kind of Chinese medicine composition of the present invention in preparation treatment menoxenia and dysmenorrhea medicine, this Chinese medicine composition can be obtained by following process route: 1. measure raw material by prescription, concoct by Chinese Pharmacopoeia and provincial standard concocted specification, feed intake after qualified; 2. above eight flavors are ground into coarse powder, extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected; 3. above-mentioned 2. medicinal residues decoct with water secondary again, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate and above-mentioned 2. aqueous solution merge, and are condensed into thick paste; 4. the above-mentioned appropriate amount of auxiliary materials that 3. adds, oven dry is pulverized, and sprays into volatile oil, and mixing is encapsulated, promptly.
The application of a kind of Chinese medicine composition of the present invention in preparation treatment menoxenia and dysmenorrhea medicine, this Chinese medicine composition can be obtained by following selection process route: 1. measure raw material by prescription, concoct by Chinese Pharmacopoeia and provincial standard concocted specification, feed intake after qualified; 2. above eight flavors are ground into coarse powder, extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected; 3. above-mentioned 2. medicinal residues decoct with water secondary again, add 8 times of water gagings for the first time, decoct 2 hours, add 6 times of water gagings for the second time, decoct 1.5 hours, filter, and merging filtrate is concentrated into relative density 1.38 (60 ℃); 4. the above-mentioned appropriate amount of starch that 3. adds, oven dry is pulverized, and sprays into volatile oil, and mixing is encapsulated, promptly.
The application of a kind of Chinese medicine composition of the present invention in preparation treatment treatment menoxenia and dysmenorrhea medicine, its Chinese medicine composition can be capsule, tablet, granule or concentrated pill.
In order to understand technology of the present invention better, be that embodiment carries out pharmacodynamic study and the toxicity test research about menoxenia, dysmenorrhea with capsule of the present invention, the new purposes of Chinese medicine composition of the present invention in pharmaceutical field is described.
One, pharmacodynamics test
Medicine and reagent: capsule of the present invention; YIMUCAO CHONGJI; The precious electuary of dysmenorrhea; Oxytocin inj; The aspirin sheet; Pentobarbital; Diethylstilbestrol; Antimony potassium tartrate; The adrenalin hydrochloride injection;
Animal subject: ICR strain white mice, SD strain rat, body weight: mice 19～22g, rat 210～260g.Rabbit, body weight: 2.50 ± 0.1kg.Animal feeding condition: laboratory air-conditioning temperature control, 23～27 ℃ of room temperatures, relative humidity 45%～75%, well-ventilated.
Instrument: blood viscometer; The packed cell volume device; Centrifuge; The isolated organ analyzer; Three meter record instrument; Amplifier; Quick balance recorder; The free movable register of mice.
(1) to the influence of animal uterus
1, to the influence of rabbit at body uterine smooth muscle myoelectrical activity
2.50 40 of ± 0.1kg healthy adult Female rabbits are divided into four groups at random, are respectively normal saline matched group, capsule of the present invention little (0.45g/kg), big (1.35g/kg) two dosage reagents group and YIMUCAO CHONGJI 1.0g/kg group.Be mixed with 4.5% and 13.5% decocting liquid during experiment, dosage is 10mL/kg, gastric infusion (i.g) respectively, administration 3 times.During experiment, after 3% pentobarbital intravenous injection (i.v) anesthesia, cut open the belly, find out a side cornua uteri, peel off surrounding tissue, be used in the extracellular recording method of body uterine smooth muscle current potential, bipolar electrode is inserted under the perimetrium, two electrode distance 0.5cm, skin incisions is inserted a syringe needle then, makes silent electrode, after waiting to stablize 30 minutes, write down normal myoelectricity (chart speed 1mm/s, time constant 10s, normal voltage 1mv) with amplifier and monitor.I.v oxytocin 0.2u/kg (10 seconds) observed 10 minutes then, respectively organized the uterine smooth muscle shrinkage degree of rabbit injection oxytocin front and back and inject on the baseline of back to refer to height.As following table:
The result shows that capsule of the present invention has certain inhibitory action to the uterus smooth muscle contraction, and rabbit due to the oxytocin is had the obvious suppression effect in body uterine smooth muscle spasm, can alleviate the excess shrinkage of uterine smooth muscle.
2, to the influence of rat dysmenorrhea reaction due to the oxytocin
40 of 230g ± 5.42g healthy adult female rats are divided into four groups at random, are respectively normal saline matched group, capsule of the present invention little (0.25g/kg), big (0.75g/kg) two dosage reagents group and YIMUCAO CHONGJI 0.5g/kg group.The i.g successive administration is 4 times respectively.During experiment, respectively at the 2nd day of administration, give rat diethylstilbestrol (0.1mg/100g body weight) subcutaneous injection (S.C), fasting 8h, lumbar injection (i.p) gives oxytocin 0.1u/kg (10 seconds) observation 30 minutes respectively, respectively organize rat owing to the uterus excess shrinkage, the incubation period that the reaction of dysmenorrhea sample occurs.As following table:
The result shows that capsule of the present invention has tangible mitigation to rat dysmenorrhea sample reaction due to the oxytocin, can prolong its response latency.
(2) analgesic test
1, oxytocin is caused the algospasm inhibitory action of rat
40 of the healthy adult female rats of 220g ± 7.85g are divided equally four groups: normal saline matched group, capsule of the present invention little (3.0g/kg), big (9.0g/kg) two dosage reagents group and the precious electuary of dysmenorrhea (6.0g/kg) group at random.All animals gave estradiol 10 days (the 1st, 10 two day S.C 0.5mg//day continuously, be 0.2mg//day in other eight days), again at interval after 40 hours, each treated animal i.g gives relative medicine (1ml/100g), after 40 minutes, i.p oxytocin 2u/ only, turning round appears in the observed and recorded animal turns round the body number of times in incubation period and 40 minutes of body, and calculates the analgesia rate.As following table:
The result shows that capsule of the present invention has significant analgesia role to rat dysmenorrhea spasm due to the oxytocin.
2, paratartaric acid antimony potassium causes the inhibitory action of mouse writhing reaction
48 of 19-22g healthy mices are divided equally four groups (12/group): normal saline matched group, capsule of the present invention little (1.5g/kg), big (4.5g/kg) two dosage reagents group and aspirin sheet (0.2g/kg) group at random.The equal i.g of each treated animal (0.2ml/10g) gives behind the relative medicine 40 minutes, i.p0.05% antimony potassium tartrate 0.2ml/ only, write down in 15 minutes animal and turn round body incubation period and turn round the body number of times, and calculate analgesia rate { %=((matched group is turned round body number of times-medication group and turned round the body number of times)/matched group is turned round the body number of times) * 100%}.As following table:
The result shows that capsule of the present invention can make antimony potassium tartrate cause mice and turn round and obviously prolong the incubation period of body, obviously reduces and turn round the body number of times.
(3) antiinflammatory test
1, to the inhibitory action of white mice auricle edema due to the Oleum Tiglii
40 of 18～22g healthy mices are divided equally four groups: normal saline matched group, capsule of the present invention little (1.0g/kg), big (3.0g/kg) two dosage reagents group and aspirin sheet (0.2g/kg) group at random.The equal i.g of each treated animal (0.2ml/10g) give relative medicine for three days on end after, fasting 8h, only being applied to a mice left side with 2% Oleum Tiglii proinflammatory agent 0.05ml/ surveys on the auricular concha, all take off neck behind the 4h and put to death mice, with diameter 5mm card punch every left and right auricular concha same area of mice is taken off, on analytical balance, weighs, and every obtain about the weight difference of two ears, amalgamation result carries out the comparison of inflammation suppression ratio between each group.As following table:
The result shows that capsule of the present invention has significant inhibitory effect to Oleum Tiglii induced mice auricle edema.
2, to the inhibitory action of rat pedal swelling due to the Ovum Gallus domesticus album:
40 of 220～300g healthy rats are divided equally four groups: normal saline matched group, capsule of the present invention little (3.0g/kg), big (9.0g/kg) two dosage reagents group and aspirin sheet (0.4g/kg) group at random.Left side ankle subcutaneous injection 100% egg clear liquid 0.03ml/ only causes inflammation.Yu Zhiyan is preceding 60,30min and when causing inflammation at once, 30, the equal i.g of each treated animal (1ml/100g) gives relative medicine behind the 60min.Respectively measure the joint girth one time after causing scorching 1h, 2h, 4h, 6h.Obtaining each times two joints of foot girth difference is the swelling degree, and amalgamation result carries out the comparison of inflammation suppression ratio between each group.As following table:
The result shows that capsule of the present invention has significant inhibitory effect to rat paw edema.
(4) blood stasis model rat blood rheology test
46 of the Healthy female rats of 240 ± 10.85g, divide five groups (every group of 8-10 only) at random, intact animal's matched group, blood stasis model matched group, capsule of the present invention little (0.9g/kg), big (2.7g/kg) two dosage reagents group and precious electuary (2g/kg) positive drug of dysmenorrhea matched group.Below respectively organizing respectively, i.g gives relative medicine (1ml/100g), continuous seven days, S.C adrenalin hydrochloride (Adr) (0.08ml/100g) twice totally (4 hours at interval) behind time medicine, injecting preceding 2 hours for the second time, rat is immersed in the frozen water, take out after 5 minutes, fasting, in heart extracting blood next day, place respectively in the test tube and erythrocyte (RBC) hematocrit pipe that contains heparin, the former is heparin blood coagulation 2ml, puts in the viscometer sample cell and (heightens the rate of cutting 100, the low rate 10 of cutting), carry out blood viscosity with capillary tube method and measure; The latter centrifugal 30 minutes with 3000rpm observes hematocrit pipe scale, gets packed cell volume (HCT), carries out fibrinogen assay with biuret method.As following table:
The result shows obviously blood viscosity lowering of capsule of the present invention, and certain effect of invigorating blood circulation is arranged, and sticking, dense, coagulableblood rheological characteristic that the blood stasis model rat is showed are alleviated.
(5) sedation test
40 of 21-25g healthy mices are divided equally four groups: normal saline matched group, capsule of the present invention little (2.5g/kg), big (7.5g/kg) two dosage reagents group and aspirin sheet (0.2g/kg) group at random.Dosage is 20ml/kg, experiment the morning 9:00-11:00 point carry out, behind the medicine 45 minutes, per 4 one group, intersect and put into the movable photoelectric counting active box of mice, one in every case, the movable number of times of record 5min mice, and compare with matched group.As following table:
The result shows that capsule of the present invention has tangible sedation.
By above-mentioned pharmacodynamics test, confirmed that capsule of the present invention has certain inhibitory action to the uterus smooth muscle contraction, rabbit due to the oxytocin is had the obvious suppression effect in body uterine smooth muscle spasm, can alleviate the excess shrinkage of uterine smooth muscle; Rat dysmenorrhea sample reaction due to the oxytocin there is tangible mitigation, can prolongs its response latency; Rat dysmenorrhea spasm due to the oxytocin there is significant analgesia role; Can make antimony potassium tartrate cause mice and turn round and obviously prolong the incubation period of body, obviously reduce and turn round the body number of times; The inhibitory action that Oleum Tiglii induced mice auricle edema is had highly significant; The inhibitory action that rat paw edema is had highly significant; Obvious blood viscosity lowering; Has tangible sedation.These animal pharmacodynamics tests provide reliable foundation for the effectiveness of capsule of the present invention.
Two, toxicity test
(1) acute toxicity test
Volume so that drug level and animal can bear has carried out maximum tolerated dose (MTD) to capsule of the present invention and has measured.With the medicine of given Cmax and capacity, 3 times/day, give mouse stomach (i.g) 0.9ml/10g/ time, totally one day, observed 14 days, its MTD is that 68g/kg (is equivalent to 178.2g crude drug/kg), tolerate human oral (P.O) consumption more than 100 times.Be about 600 times of clinical consumption.
(2) long term toxicity test
Because capsule toxicity of the present invention is low, does not make oral LD
50Only measure maximum tolerated dose, according to the clinical application amount and the course of treatment, capsule of the present invention is carried out the research of rat long term toxicity, when rat oral gavage gives capsule powder 12g/kg/d of the present invention (clinical consumption is more than 100 times), 6g/kg/d successive administration six months, animal generally in order, weight increase and every blood parameters no abnormality seen.Drug withdrawal recovered for two weeks, except that capsule 6g/kg/d group body weight gain of the present invention is considerably slower than (P＜0.05) the blank group, every blood and biochemical indicator no abnormality seen.Anatomy and pathology checks that each internal organs is not seen pathological change, shows that capsule of the present invention is safer.
To sum up pharmacodynamics test, toxicity test result, show a kind of Chinese medicine composition safety non-toxic of the present invention, menoxenia and dysmenorrhea all there is obvious therapeutic effect, a kind of Chinese medicine composition of proof the present invention is safe and effective, is applicable to the various symptoms that unmarried women or married female irregular menstruation and dysmenorrhea cause.
The specific embodiment
Below in conjunction with instantiation the present invention is described in further detail, but is not to be used for limiting protection scope of the present invention.
Pharmaceutical formulation:
Radix Angelicae Sinensis 240g Rhizoma Chuanxiong 90g Radix Glycyrrhizae (processing) 15g
Semen Persicae 24g Rhizoma Zingiberis (charcoal) 15g Herba Leonuri 300g
Flos Carthami 15g Radix Cynanchi Paniculati 50g
Preparation method:
More than eight flavors, be ground into coarse powder, extract volatile oil with the way of distillation, the aqueous solution after the distillation in addition device is collected; Medicinal residues decoct with water secondary again, add 8 times of water gagings for the first time, decoct 2 hours, add 6 times of water gagings for the second time, decoct 1.5 hours, filter, and merging filtrate, filtrate and above-mentioned aqueous solution merge, and are concentrated into relative density 1.38 (60 ℃); Add appropriate amount of starch, oven dry is pulverized, and sprays into volatile oil, and mixing is encapsulated, makes 156, promptly.
Claims (7)
1. the application of Chinese medicine composition in preparation treatment menoxenia and dysmenorrhea medicine, described a kind of Chinese medicine composition is characterized in that the composition of this Chinese medicine composition and weight proportion are:
Radix Angelicae Sinensis 32.04% Rhizoma Chuanxiong, 12.02% Radix Glycyrrhizae (processing) 2.00%
Semen Persicae 3.21% Rhizoma Zingiberis (charcoal) 2.00% Herba Leonuri 40.05%
Flos Carthami 2.00% Radix Cynanchi Paniculati 6.68%.
2. the application of the described a kind of Chinese medicine composition of claim 1 in preparation treatment menoxenia and dysmenorrhea medicine, it is characterized in that menstrual cycle, menstrual period that described menoxenia can cause for a variety of causes or the various significant discomfort symptoms that change and follow appearance through amount, comprise that preceeded menorrhea, delayed menstrual cycle, menstruation irregularly successively, menostaxis, metrorrhagia such as hypomenorrhea, menorrhagia.
3. the application of the described a kind of Chinese medicine composition of claim 1 in preparation treatment menoxenia and dysmenorrhea medicine, it is characterized in that described dysmenorrhea can periodically hypogastralgia occur in menstrual period or its front and back for the women that a variety of causes causes, comprises primary dysmenorrhea and/or secondary dysmenorrhea.
4. the application of a kind of Chinese medicine composition according to claim 1 in preparation treatment menoxenia and dysmenorrhea medicine is characterized in that this Chinese medicine composition can be obtained by following process route:
1. measure raw material by prescription, concoct, feed intake after qualified by Chinese Pharmacopoeia and provincial standard concocted specification;
2. above eight flavors are ground into coarse powder, extract volatile oil with the way of distillation, and the aqueous solution after distillation device is in addition collected;
3. above-mentioned 2. medicinal residues decoct with water secondary again, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate and above-mentioned 2. aqueous solution merge, and are condensed into thick paste;
4. the above-mentioned appropriate amount of auxiliary materials that 3. adds, oven dry is pulverized, and sprays into volatile oil, and mixing is encapsulated, promptly.
5. the preparation were established of a kind of Chinese medicine composition according to claim 4 is characterized in that decocting with water secondary during step 3., adds 8 times of water gagings for the first time, decocted 2 hours, and added 6 times of water gagings for the second time, decocted 1.5 hours, filter, merging filtrate is concentrated into relative density 1.38 (60 ℃).
6. adjuvant according to claim 4 is characterized in that it can be starch or dextrin.
7. the application of a kind of Chinese medicine composition according to claim 1 in preparation treatment menoxenia and dysmenorrhea medicine is characterized in that this Chinese medicine composition can be capsule, tablet, granule or concentrated pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100175133A CN101264302A (en) | 2007-03-16 | 2007-03-16 | Application of Chinese medicinal composition in preparing medicaments for treating menoxenia and menorrhalgia |
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| CNA2007100175133A CN101264302A (en) | 2007-03-16 | 2007-03-16 | Application of Chinese medicinal composition in preparing medicaments for treating menoxenia and menorrhalgia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142740A (en) * | 2013-03-12 | 2013-06-12 | 熊烈 | Chinese herbal medicine mixture for treating abdominal pain and diarrhea and preparation method thereof |
| CN105435090A (en) * | 2015-09-18 | 2016-03-30 | 朱玲 | Traditional Chinese medicine composition for treating secondary dysmenorrhea caused by qi deficiency and blood stasis and preparation method of traditional Chinese medicine composition |
-
2007
- 2007-03-16 CN CNA2007100175133A patent/CN101264302A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142740A (en) * | 2013-03-12 | 2013-06-12 | 熊烈 | Chinese herbal medicine mixture for treating abdominal pain and diarrhea and preparation method thereof |
| CN103142740B (en) * | 2013-03-12 | 2015-03-18 | 熊烈 | Chinese herbal medicine mixture for treating abdominal pain and diarrhea and preparation method thereof |
| CN105435090A (en) * | 2015-09-18 | 2016-03-30 | 朱玲 | Traditional Chinese medicine composition for treating secondary dysmenorrhea caused by qi deficiency and blood stasis and preparation method of traditional Chinese medicine composition |
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