CN105641621A - Granules for treating phlegm and blood stasis simultaneously and taking method of granules - Google Patents
Granules for treating phlegm and blood stasis simultaneously and taking method of granules Download PDFInfo
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- CN105641621A CN105641621A CN201610093258.XA CN201610093258A CN105641621A CN 105641621 A CN105641621 A CN 105641621A CN 201610093258 A CN201610093258 A CN 201610093258A CN 105641621 A CN105641621 A CN 105641621A
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- 239000008280 blood Substances 0.000 title claims abstract description 60
- 206010062717 Increased upper airway secretion Diseases 0.000 title claims abstract description 42
- 208000026435 phlegm Diseases 0.000 title claims abstract description 42
- 239000008187 granular material Substances 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 19
- 241000237903 Hirudo Species 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
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- 239000003814 drug Substances 0.000 abstract description 24
- 238000002360 preparation method Methods 0.000 abstract description 4
- 244000001632 Acorus gramineus Species 0.000 abstract 2
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- 235000003398 Curcuma aromatica Nutrition 0.000 abstract 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention relates to a preparation method of a traditional Chinese medicine for treating phlegm and blood stasis simultaneously, in particular to granules for treating phlegm and blood stasis simultaneously and a taking method of the granules. The granules are mainly prepared from extraction solutions of Trichosanthes fruits, Salvia Miltiorrhiza, longstamen onion bulb, leeches, acorus gramineus, curcuma aromatica, Wolfiporia extensa and dried tangerine peel with a granulation process. Besides, every 1,000 g of the granules comprise 416 g of the Trichosanthes fruits, 416 g of the Salvia Miltiorrhiza, 277 g of the longstamen onion bulb, 138 g of the leeches, 277 g of the acorus gramineus, 416 g of the curcuma aromatica, 555 g of the Wolfiporia extensa and 277 g of the dried tangerine peel. The granules for treating phlegm and blood stasis simultaneously have high content of active ingredients and are stable in performance.
Description
Technical field
The present invention relates to that a kind of expectorant is turbid, the preparation method of the Chinese medicine preparation of blood stasis for treating simultaneously, specifically, relate to a kind of removing both phlegm and blood stasis at the same time granule and instructions of taking thereof.
Background technology
Traditional Chinese Medicine is thought, expectorant is turbid, blood stasis is the not normal pathological product of body essence of water and grain metabolism. The transportation capabilities turbid interior life of not normal then expectorant of spleen, stops in aqueous vapor, is aggregated into expectorant, through BI-syndrome involved the blood vessels hinder, be thus retention of dampness due to stagnation of QI, expectorant blood coagulation stasis of blood cross-reference and fall ill. In recent years in the thoracic obstruction, apoplexy, quench one's thirst etc. in sick clinical practice, the expectorant stasis of blood has been had with disease further insight and attention, often with " phlegm stagnation in collateral ", " expectorant stasis of blood knot ", " condensation of the expectorant stasis of blood ", " the expectorant stasis of blood is stopped up stagnant " etc. for dialectical, adopt and eliminate the phlegm Removing Blood Stasis Recipe treatment and obtain good effect.
Prior art also discloses that multiple have treatment simultaneously expectorant is turbid, the Chinese medicine composition of blood stasis, but mostly have that effective component content is low, dose big, absorb not exclusively, bioavailability is low, drug effect play relatively slow, carry the deficiencies such as inconvenience.
Summary of the invention
In order to overcome certain or some defect of prior art, the invention provides a kind of removing both phlegm and blood stasis at the same time granule.
Removing both phlegm and blood stasis at the same time granule according to the present invention, it mainly by the extracting solution of Fructus Trichosanthis, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, Hirudo, Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae, obtains through granulating process.
As preferably, in this granule of every 1000g, including raw material Fructus Trichosanthis 416g, Radix Salviae Miltiorrhizae 416g, Bulbus Allii Macrostemonis 277g, Hirudo 138g, Rhizoma Acori Graminei 277g, Radix Curcumae 416g, Poria 555g and Pericarpium Citri Reticulatae 277g.
As preferably, described extracting solution, Fructus Trichosanthis, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, Hirudo, Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae decoct successively after jointly soaking 3 times, and the decoction liquor obtained will be decocted every time merge and obtain.
As preferably, the common soak time of Fructus Trichosanthis, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, Hirudo, Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae is 20��40min.
As preferably, in described decoction 3 times, first time decocting time is 80��120min, and second time decocting time is 50��70min, and third time decocting time is 20��40min.
In the present invention, decoct by medical material being carried out suitable immersion and three times, it is possible to preferably obtain the effective ingredient in crude drug.
In order to overcome certain or some defect of prior art, the invention provides the instructions of taking of a kind of removing both phlegm and blood stasis at the same time granule, it can be used in any of the above-described kind of removing both phlegm and blood stasis at the same time granule.
The instructions of taking of the removing both phlegm and blood stasis at the same time granule according to the present invention, removing both phlegm and blood stasis at the same time granule is packaged with packed by it by single use dosage, takes one bag every time, and boiled water is taken after mixing it with water.
In the present invention, it is possible to Fructus Trichosanthis and Radix Salviae Miltiorrhizae altogether for monarch drug. Wherein: Fructus Trichosanthis is sweet in flavor and cold in property, can removing heat-phlegm, again can eliminating stagnation clearing away phlegm; Radix Salviae Miltiorrhizae cold nature bitter in the mouth, not only promoting the circulation of blood but also nourish blood. Fructus Trichosanthis and Radix Salviae Miltiorrhizae two medicine share, it is possible to play removing blood stasis effect of preferably reducing phlegm.
In the present invention, it is possible to Bulbus Allii Macrostemonis and Hirudo altogether for ministerial drug. Wherein: the logical sliding profit of Bulbus Allii Macrostemonis temperature, activate yang pain relieving; Hirudo merit is apt to blood circulation promoting and blood stasis dispelling. It is ministerial drug altogether by adopting Bulbus Allii Macrostemonis and Hirudo, it is possible to the promoting the circulation of QI preferably strengthening monarch drug (Fructus Trichosanthis and Radix Salviae Miltiorrhizae) reduces phlegm, dissipates the effects such as pitch width breast, promoting the circulation of blood removing blood stasis, blood-nourishing blood-generating.
In the present invention, it is possible to Rhizoma Acori Graminei or Radix Curcumae or Poria or Pericarpium Citri Reticulatae or certain several be combined as adjuvant drug. Rhizoma Acori Graminei and Radix Curcumae are used alone or share can have removing dampness eliminating phlegm, removing heat from the heart to restore the consciousness effect. Poria and Pericarpium Citri Reticulatae are used alone or share can have eliminating phlegm and removing dampness, regulating qi-flowing for strengthening spleen effect.
In each medical material adopted in the present invention:
Fructus Trichosanthis is sweet in flavor and cold in property, can removing heat-phlegm, again can eliminating stagnation clearing away phlegm, " can wash in septum pectorale dirt greasy hot and suffocating ", " not Lu " calls its " main thoracic obstruction ";
The logical sliding profit of Bulbus Allii Macrostemonis temperature, activate yang pain relieving;
By Fructus Trichosanthis and Bulbus Allii Macrostemonis are share, it is possible to promoting the circulation of QI reduces phlegm, dissipates pitch width breast, warming and activating heart-YANG;
Radix Salviae Miltiorrhizae and Hirudo all can preferably blood circulation promoting and blood stasis dispelling, " gas is rotten for salty in the mouth, color, and property is put down to record Hirudo in " Records of Tradition Chinese and Western Medicine in Combination ". For its salty in the mouth, therefore it is apt to into blood system; It was bloodthirsty thing originally for it, therefore kind removing blood stasis; Rotten for its gas, its abnormal smells from the patient is moved and inspired mutually with blood stasis, does not move and inspire mutually with fresh blood, therefore but removing blood stasis with potent drugs and do not hinder fresh blood ";
Radix Salviae Miltiorrhizae cold nature bitter in the mouth, GUIXIN, Liver Channel, " herbal classic " records " main trusted subordinate's pathogen ... abolish abdominal mass, only stuffy sensation with restlessness, QI invigorating ", has the merit of blood stasis dispelling blood, tissue regeneration promoting blood, not only promoting the circulation of blood but also nourish blood.
By Radix Salviae Miltiorrhizae and Hirudo being share, can not only preferably strengthen the power of the blood circulation promoting and blood stasis dispelling of the present invention, but also can preferably " promoting the circulation of blood removing blood stasis, blood-nourishing blood-generating ";
Poria promoting diuresis with drugs of tasteless flavour, spleen invigorating mind calming, " simply, for controlling expectorant principal agent, originally, also, Poria can row water for water for expectorant for Poria in " generation mends vegetarian medical skill " record. Expectorant is dynamic, wets also, and Poria is feasible wet again ";
Rhizoma Acori Graminei has removing dampness calming effects, " Bencao Congxin " call it " arduous and warm, fragrance and dissipate, happy hole, sharp nine orifices ... dry ... by expectorant " etc.;
Rhizoma Acori Graminei and Poria share, it is possible to preferably increase the present invention and eliminate the phlegm effect of removing dampness;
Essentials of Matea Medica records Radix Curcumae " circulation of qi promoting, resolving depression ... cool heat in the heart dissipates stagnation of liver-QI ", and the pungent perfume (or spice) of Pericarpium Citri Reticulatae is walked and altered channels, promoting the circulation of QI to relieve pain, the meaning of reside " gas row then blood ", " gas row expectorant is from disappearing ".
In the present invention, all medicines mutually 5, regulating qi and dredging collateral eliminates the phlegm, promoting blood circulation, removing blood stasis and relieving pain, eliminates the phlegm and not dry, blood stasis dispelling and do not feel frustrated, play the merit of the blood-activating analgetic that eliminates the phlegm altogether.
According to the obtained granule of method provided by the present invention when being applied to syndrome of intermin-gled phlegm and blood stasis patient, it is possible to be substantially better than the medicine of prior art. The application is incorporated herein and is documented in the experimental data in " volume the 7th phase July the 25th in 2010 in " China's Chinese medicine academic periodical " (former " China's Chinese medicine journal "); article name " impact that Phlegm Stasis Type of Coronary Heart Disease is tied card tcm syndrome by removing both phlegm and blood stasis at the same time granule mutually and PPAR �� expresses " " and " " China's Chinese medicine academic periodical " volume the 1st phase January the 28th in 2010; article name " impact on coronary heart disease blood fat of the removing both phlegm and blood stasis at the same time granule " ", using as the evidence to the curative effect according to the obtained medicine of the inventive method.
Experimental data in two sections of documents introduced above, it is all based on drawing according to the obtained medicine of the inventive method, by two sections of documents introduced above, can learn, be obtained in that substantially preferably therapeutic effect when being applied to syndrome of intermin-gled phlegm and blood stasis patient according to the obtained granule of the inventive method.
Detailed description of the invention
For further appreciating that present disclosure, the present invention is described in detail in conjunction with the embodiments. It should be appreciated that embodiment be only the present invention made an explanation and and non-limiting.
Embodiment 1
Present embodiments providing a kind of removing both phlegm and blood stasis at the same time granule and instructions of taking thereof, this granule mainly by the extracting solution of Fructus Trichosanthis, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, Hirudo, Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae, obtains through granulating process.
The preparation technology of the removing both phlegm and blood stasis at the same time granule in the present embodiment is as follows:
(1) soak, take Fructus Trichosanthis 416g, Radix Salviae Miltiorrhizae 416g, Bulbus Allii Macrostemonis 277g, Hirudo 138g, Rhizoma Acori Graminei 277g, Radix Curcumae 416g, Poria 555g and Pericarpium Citri Reticulatae 277g, add water appropriate, soak 20��40min (being 30min in the present embodiment);
(2) first time decocting liquid, decocts 80��120min (being 90min in the present embodiment), obtains first time decocting liquid and decocts slag with first time;
(3) second time decocting liquid, decocts slag by first time and adds water in right amount, decoct 50��70min (being 60min in the present embodiment), obtains second time decocting liquid and decocts slag with second time;
(4) third time decocting liquid, decocts slag by second time and adds water in right amount, decoct 20��40min (being 30min in the present embodiment), obtains third time decocting liquid;
(5) obtain collecting decoction, first time decocting liquid, second time decocting liquid and third time decocting liquid are mixed to obtain collecting decoction;
(6) filter, be combined decocting liquid and be filtered operation to obtain decocting liquid filtrate;
(7) first time concentration, is concentrated into relative density about 1.08 (60 DEG C) by decocting liquid filtrate, thus obtaining first time concentrated solution;
(8) extracting, adding ethanol in first time concentrated solution is 55%��65% to alcohol content, stirs, and cold preservation 10��14 hours (being 12 hours in the present embodiment);
(9) second time concentration, the supernatant that step of learning from else's experience (8) obtains after processing, decompression recycling ethanol is to without alcohol taste, being concentrated into relative density and be about 1.30 (60 DEG C), thus obtaining second time concentrated solution;
(10) granulate, in second time concentrated solution, add appropriate soluble starch, dry and make the granule of 1000g.
In the present embodiment, prepared granule is packaged with packed form, and the weight of every bag is 6g.
The instructions of taking of the removing both phlegm and blood stasis at the same time granule in the present embodiment is as follows, and patient in use, every day 3 times, takes one bag every time, and boiled water is taken after mixing it with water.
It should be noted that, the present embodiment provide only a kind of detailed description of the invention of the present invention, it is only used as the explanation that the present invention is carried out and non-limiting. It practice, when practical application, it is possible to the concrete symptom according to patient, it is possible to the proportioning of raw material is carried out suitable adjustment, and Radix Curcumae and Pericarpium Citri Reticulatae can be removed according to practical situation. The proportioning of raw material is carried out suitable when adjusted, it should follow: Fructus Trichosanthis and Radix Salviae Miltiorrhizae are monarch drug, and weight portion respectively Fructus Trichosanthis 2��5 parts, Radix Salviae Miltiorrhizae 2��4 parts; Bulbus Allii Macrostemonis and Hirudo are ministerial drug, and weight portion respectively Bulbus Allii Macrostemonis 1.5��3 parts, Hirudo 0.5��1.5 part; Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae are adjuvant drug, and weight portion respectively Rhizoma Acori Graminei 1��2.5 part, Radix Curcumae 2.5��5 parts, 3��4.5 parts of Poria, Pericarpium Citri Reticulatae 1.5��2.5 parts.
The granule prepared in the present embodiment possess preferably dehumidifying eliminate the phlegm, the effect such as blood circulation promoting and blood stasis dispelling, it is possible to being preferably used for coronary heart diseases and angina pectoris, feeling of oppression and pain in the chest, cardiopalmus is had palpitation, the symptoms such as indigestion and loss of appetite gastral cavity is swollen, heaviness of the head and fatigue of the body, and abundant expectoration is fat.
Below schematically the present invention and embodiment thereof being described, this description is not restricted. So, if those of ordinary skill in the art is enlightened by it, when without departing from the invention objective, without creatively designing the scheme similar to this technical scheme and embodiment, protection scope of the present invention all should be belonged to.
Claims (6)
1. removing both phlegm and blood stasis at the same time granule, it mainly by the extracting solution of Fructus Trichosanthis, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, Hirudo, Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae, obtains through granulating process.
2. removing both phlegm and blood stasis at the same time granule according to claim 1, it is characterised in that: in every this granule of 1000g, including raw material Fructus Trichosanthis 416g, Radix Salviae Miltiorrhizae 416g, Bulbus Allii Macrostemonis 277g, Hirudo 138g, Rhizoma Acori Graminei 277g, Radix Curcumae 416g, Poria 555g and Pericarpium Citri Reticulatae 277g.
3. removing both phlegm and blood stasis at the same time granule according to claim 1, it is characterized in that: described extracting solution, decoct successively after jointly being soaked by Fructus Trichosanthis, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, Hirudo, Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae 3 times, and the decoction liquor merging obtained will be decocted every time and obtain.
4. removing both phlegm and blood stasis at the same time granule according to claim 3, it is characterised in that: the common soak time of Fructus Trichosanthis, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, Hirudo, Rhizoma Acori Graminei, Radix Curcumae, Poria and Pericarpium Citri Reticulatae is 20��40min.
5. removing both phlegm and blood stasis at the same time granule according to claim 4, it is characterised in that: in described decoction 3 times, first time decocting time is 80��120min, and second time decocting time is 50��70min, and third time decocting time is 20��40min.
6. the instructions of taking of removing both phlegm and blood stasis at the same time granule described in claim 1, it is characterised in that: being packaged with packed by this granule by single use dosage, take one bag every time, boiled water is taken after mixing it with water.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010705A (en) * | 2018-11-01 | 2018-12-18 | 浙江省中医院 | The preparation method of removing both phlegm and blood stasis at the same time particle |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN101874889A (en) * | 2010-04-23 | 2010-11-03 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating gastric stuffiness and preparation method thereof |
| CN102631538A (en) * | 2012-04-20 | 2012-08-15 | 蔡惠磊 | Traditional Chinese medicine for treating heart disease |
| CN102836320A (en) * | 2012-10-08 | 2012-12-26 | 河南中医学院 | Chinese medicinal pill for treating tachyarrhythmia |
-
2016
- 2016-02-19 CN CN201610093258.XA patent/CN105641621B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN101874889A (en) * | 2010-04-23 | 2010-11-03 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating gastric stuffiness and preparation method thereof |
| CN102631538A (en) * | 2012-04-20 | 2012-08-15 | 蔡惠磊 | Traditional Chinese medicine for treating heart disease |
| CN102836320A (en) * | 2012-10-08 | 2012-12-26 | 河南中医学院 | Chinese medicinal pill for treating tachyarrhythmia |
Non-Patent Citations (2)
| Title |
|---|
| 戴金，江丹娜: "痰瘀同治颗粒对冠心病痰瘀互结证中医证候和PPARγ表达的影响", 《中华中医药杂志》 * |
| 江丹娜，戴金: "痰瘀同治颗粒对冠心病血脂的影响", 《中华中医药学刊》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010705A (en) * | 2018-11-01 | 2018-12-18 | 浙江省中医院 | The preparation method of removing both phlegm and blood stasis at the same time particle |
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