CN103550586B - Granules for treating alcoholic cardiomyopathy arrhythmia and preparation method thereof - Google Patents
Granules for treating alcoholic cardiomyopathy arrhythmia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a method for preparing granules for treating alcoholic cardiomyopathy arrhythmia. The granules are applied to the therapy of alcoholic cardiomyopathy. The method is characterized by comprising the steps of (1) distilling Litchi chinensis Sonn., Stachys kouyangensis(Van.) Dunn and Aeschynomene indica L. by water vapor, so as to extract volatile oil for later use, and enabling dregs to be standby; (2) crushing Gekko gecko Linnaeus and Setaria italica (L.) Beauv. into fine powder for later use; (3) uniformly mixing Selaginella tamariscina (Beauv.) Spring, Begonia handelii Irmsch., Poncirus tuifoliata (L.) Raf., Polygonum aviculare L., Magnolia amoena Cheng, Dracocephalum moldavica L., Callicarpa nudiflora Hook. Et Arn. and the dregs obtained in the step (1), carrying out ethanol extraction twice, merging two alcohol extracts, filtrating, recovering ethanol, and carrying out depressurized concentration, so as to form an extract; (4) adding the fine powder obtained in the step (2) into the extract obtained in the step (3), uniformly mixing, drying at the temperature of 60 DEG C, crushing into fine powder, adding polysorbate-80, granulating, drying, finishing, spraying the volatile oil obtained in the step (1), uniformly mixing, and packaging granules, thereby obtaining the granules. Proved by clinical trials, the granules have the characteristics of good treatment effect and relatively high safety in the therapy of alcoholic cardiomyopathy, so that the granules are worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of preparation method for the treatment of alcoholic cardiomyopathy arrhythmia granule.
Background technology
Alcoholic cardiomyopathy (alcoholic cardiomyopathy.ACM) onset is hidden, and be more common in a large amount of drink ardent spirits more than 10 years persons, general age of onset is more than 40 years old, and male is more than women.Patient symptom is different, main relevant with cardiac insufficiency and arrhythmia.Ethanol often causes dispersivity myocardial damage, and myocardial movement weakens, and cardiac output reduces.First ethanol can show as arrhythmia to myocardial damage, if now heart change is comparatively slight, it is pathologic that this arrhythmia is often considered to right and wrong.Electrocardioscopy often shows the non-specific changes such as ST-T change and left ventricular hypertrophy, with room and ventricular arrhythmia, common with atrial arrhythmia, wherein the most common with atrial fibrillation again.
During acute alcoholism, bedside cardioelectric monitor finds, ventricular premature contraction more frequently can be had in initial 12 hours to occur, found by biochemical analysis simultaneously, catecholamine levels in plasma concentration obviously raises, and this result of study shows: alcoholic cardiomyopathy, catecholamine levels in plasma concentration, arrhythmia exist parallel relation.
The key of alcoholic cardiomyopathy treating irregular heart pulse is early diagnosis, early alleviating alcohol addiction and symptomatic treatment, to continuity or reverse disease.How Chinese traditional treatment not for the ARR medicine typing of alcoholic cardiomyopathy, but is carried out opinion from the pattern of syndrome of " cardiopalmus " and is controlled.The tcm syndrome differentiation and typing of " cardiopalmus " has: the weak card of the motive, syndrome of deficiency of both qi and yin, gas sun two deficiency syndrome, but alcoholic cardiomyopathy arrhythmia is obviously different with other conductive impairment arrhythmia inherent mechanisms, the former for the domination of pathogen be main good prognosis, the latter for weakened body resistance be main poor prognosis.And current clinically manyly to control from deficiency syndrome opinion, real person reality again, cause getting half the result with twice the effort.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the preparation method of the little treatment alcoholic cardiomyopathy arrhythmia granule of side effect.
The technical scheme that the present invention solves its technical problem is: one treats the ARR pharmaceutical composition of alcoholic cardiomyopathy, it is characterized in that being prepared from by the crude drug of following weight proportion: Herba Selaginellae 10 ~ 30 parts, Herba stachydis kouyangensis 6 ~ 12 parts, 3 ~ 10 parts, ferrum rice, Cortex Ponciri trifoliatae 6 ~ 12 parts, Diplazium lanceum (Thunb) 3 ~ 10 Fen, Herba Polygoni Avicularis 6 ~ 12 parts, Semen Litchi 6 ~ 12 parts, Flos Magnoliae Amoenae 6 ~ 12 parts, Herba Dracocephali 6 ~ 12 parts, Gecko 1 ~ 5 part, Folium et Ramulus Callicarpae nudiflorae 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts.
Chinese medicine of the present invention can be prepared from by following method:
(1) Semen Litchi, Herba stachydis kouyangensis, Diplazium lanceum (Thunb) coarse powder are extracted volatile oil 6 hours with vapor distillation after soaking 4 hours separately, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Herba Selaginellae, ferrum rice, Cortex Ponciri trifoliatae, Herba Polygoni Avicularis, Flos Magnoliae Amoenae, Herba Dracocephali, Folium et Ramulus Callicarpae nudiflorae and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, mix subpackage and get final product.
Wherein said: Herba Selaginellae is the dry herb of Spikemoss plant Herba Selaginellae Selaginella tamariscina (Beauv.) Spring or Selaginella pulvinata Selaginella pulvinata (HooK.et Grev.) Maxim..Nature and flavor are pungent, flat.Return liver, heart channel.Merit can promoting blood circulation to restore menstrual flow.
Herba stachydis kouyangensis is Labiatae Herba stachydis kouyangensis Stachys kouyangensis (Van.) Dunn, with all herbal medicine.Lightly seasoned; Micro-hardship; Cool in nature.Return spleen; Heart channel.Merit can heat-clearing and toxic substances removing; Draw out pus by applying a plaster to the affected part antipruritic.
Ferrum rice is the herb of Begoniaceae plant B. brevicaulis Ku Begonia handelii Irmsch..Bitter in the mouth, cold in nature.Merit can heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling; Promoting digestion and invigorating the stomach.Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Merit can endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.
Diplazium lanceum (Thunb) is the stem pith of leguminous plant Herba Aeschynonenes Indicae stem Aeschynomene indica L..Nature and flavor are bitter, flat.Attach to the lung and stomach meridians.Heat clearing away, diuresis, lactogenesis, improving eyesight.
Herba Polygoni Avicularis is the dry aerial parts of Liao section Zhi Wu Herba Polygoni Avicularis Polygonum aviculare L..Nature and flavor are bitter, are slightly cold.Return urinary bladder channel.Merit can inducing diuresis for treating stranguria syndrome, and parasite killing is antipruritic.
Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, kidney channel.Merit can promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
Flos Magnoliae Amoenae, is Magnoliaceae head Drymotaenium miyoshianum (Mak.) Mak. Magnolia amoena Cheng, is used as medicine with alabastrum.Nature and flavor are bitter, cold.Merit can diuresis, detumescence, nourishing the lung to arrest cough.
Herba Dracocephali, be the herb of Labiatae dragonhead Herba Dracocephali Dracocephalum moldavica L., nature and flavor are pungent, bitter, cool.Merit can wind and heat dispersing; Smooth throat to stop cough; Cool liver hemostasis.
Gecko is the dry body of Gekkonidae animal Gecko Gekko gecko Linnaeus.Nature and flavor are salty, flat.Return lung, kidney channel.Merit can invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence.
Folium et Ramulus Callicarpae nudiflorae is the leaf with twig of Verbenaceae Callicarpa nudiflora Callicarpa nudiflora Hook. Et Arn..Nature and flavor are puckery, micro-pungent, bitter, flat.GUIXIN warp.Merit can be stopped blooding by dissipating blood stasis; Removing toxic substances and promoting subsidence of swelling.
Fructus Setariae Germinatus (parched to brown), for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv. is through drying of germinateing, fries to burnt brown according to frying method.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
At present, how Chinese traditional treatment not for the ARR medicine typing of alcoholic cardiomyopathy, but is carried out opinion from " cardiopalmus " pattern of syndrome and is controlled.The tcm syndrome differentiation and typing of cardiopalmus has: the weak card of the motive, syndrome of deficiency of both qi and yin, gas sun two deficiency syndrome, but alcoholic cardiomyopathy is obviously different with dilated cardiomyopathy inherent mechanism, the former for the domination of pathogen be main good prognosis, the latter is weakened body resistance is main poor prognosis.And current clinically manyly to control from deficiency syndrome opinion, real person reality again, cause getting half the result with twice the effort.
Compared with prior art, the present invention has following characteristics:
Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, kidney channel.Merit can promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
1, set forth one's views unique: controlling from positivism alcoholic cardiomyopathy arrhythmia, is that tangible heresy blocks heart network, causes heart arteries and veins stasis blocking not all right and his change raw, so get rid of evils as key element.
2, with Herba Selaginellae, Herba stachydis kouyangensis is monarch: Herba stachydis kouyangensis can be drawn out pus by applying a plaster to the affected part in heat clearing away, and " herbal classic " records Herba Selaginellae: " main the five internal organs pathogen ", " Japan hanako materia medica " Herba Selaginellae: " relieving palpitation, except face Shao-, wind syndrome of head, warming the kidney ", in the present invention, Herba Selaginellae dosage is obviously greater than conventional amount used, the proportioning of this kind of dosage can the myocardiac myocardial damage of alleviation of alcohol, its effect is confirmed by Basic pharmacology institute: male SD rat is with 10g/kg/d dosage " strong, colourless liquor distilled from sorghum " (52 ° of v/v) gavage after 15 days, Ventricular Myocytes contractility reduces by 40.2%, in blood, catecholamine concentration obviously raises, myocardium markers section presents alcoholic cardiomyopathy performance, this pathological model rat is via after Herba Selaginellae (20g crude drug/kg/d) and Herba stachydis kouyangensis (10g crude drug/kg/d) mixing water decocting liquid gavage 14d, Ventricular Myocytes contractility compares with normal rat, ventricular muscle cell contractility reduces by 7.7%, and the ventricular muscle cell contractility of same batch alleviating alcohol addiction rat is still lower than normal rat 36.3%, the two comparing difference very obviously (P<0.01), in medication group rat blood catecholamine concentration also comparatively master mould have obvious decline.This basic research shows: Herba Selaginellae and Herba stachydis kouyangensis 2:1 mixing water decocting liquid can improve alcoholic cardiomyopathy rat model ventricular muscle cell contractility and reduce and blood catecholamine concentration rising condition.
3, monarch drug is assisted to get rid of evils using ferrum rice heat-clearing and toxic substances removing dissipating blood stasis, the diuresis of Diplazium lanceum (Thunb) heat clearing and damp drying, Herba Dracocephali wind and heat dispersing, Cortex Ponciri trifoliatae eleminating phlegm and freeing channels, Herba Polygoni Avicularis diuresis, Flos Magnoliae Amoenae mass dissipating and swelling eliminating, Semen Litchi promoting QI to circulate and dispersing the agglomeration of the pathogens as ministerial drug.And be oxidized Diplazium lanceum (Thunb) phenolic constituent to intravenous rabbit injection 25mg/kg, shorten the arrhythmia recovery time that epinephrine brings out, therapeutic administratp shorten in average 52%, prevention administration shorten in average 24%.In " accumulation of blood is both of a specified duration; also can turn to expectorant water " (" treatise on blood trouble " rolls up five) myocardium network, QI and blood is not all right, then accumulation of phlegm retardance of a specified duration, breath does not reach, so select Cortex Ponciri trifoliatae, Herba Polygoni Avicularis, Flos Magnoliae Amoenae, Flos Magnoliae Amoenae water extract 10g(crude drug)/kg lumbar injection, show antagonism aludrine induced mice myocardium keto consumption increasing action, improve its hypoxia-bearing capability.
4, help with Gecko invigorating the lung and the kidney tonify deficiency subduing the wind syndrome assistant, wherein the aminoacid that contains of Gecko and phospholipid composition can reduce the content of malonaldehyde in cell membrane (MDA), play the effect of stabilizing cell membrane.
5, low dose of Folium et Ramulus Callicarpae nudiflorae, Semen Litchi are corrigent, Folium et Ramulus Callicarpae nudiflorae resists blood circulation promoting and blood stasis dispelling in this prescription too much has hemorrhage anxiety, the feature of this medicament selection is the bleeding time that decocting liquid can shorten rabbit, but on rabbit clotting time then without impact, can not with other drug function conflict or counteracting in this prescription; The micro-bitter temperature of Semen Litchi, cold-dispelling pain-relieving, prevents above-mentioned heat clearing away medicine too cold and cool; And the effect of Folium et Ramulus Callicarpae nudiflorae removing toxic substances and promoting subsidence of swelling, Semen Litchi promoting QI to circulate and dispersing the agglomeration of the pathogens also can contribute to getting rid of evils.
6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns taste warp, in one cold and cool medicine, get protect sun defend in meaning.
7, institute's thing of getting it filled homogeneous medicine multiple-effect in side, contributes to reducing medicament categories and consumption, does not increase Liver and kidney burden after wound.
8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
9, because alcoholic cardiomyopathy needs the medication cycle long, so adopt granule dosage form, taking convenience, compliance is good, is convenient to the consolidation of the course for the treatment of.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Selaginellae 20g, Herba stachydis kouyangensis 10g, ferrum rice 6g, Cortex Ponciri trifoliatae 10g, Diplazium lanceum (Thunb) 6g, Herba Polygoni Avicularis 10g, Semen Litchi 10g, Flos Magnoliae Amoenae 10g, Herba Dracocephali 10g, Gecko 2g, Folium et Ramulus Callicarpae nudiflorae 6g, Fructus Setariae Germinatus (parched to brown) 20g.
The preparation method of embodiment 1 is: Herba Selaginellae, Herba stachydis kouyangensis, ferrum rice, Cortex Ponciri trifoliatae, Diplazium lanceum (Thunb), Herba Polygoni Avicularis, Semen Litchi, Flos Magnoliae Amoenae, Herba Dracocephali, Gecko, Folium et Ramulus Callicarpae nudiflorae, Fructus Setariae Germinatus (parched to brown) mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, crude drug weight proportion: Herba Selaginellae 10 parts, Herba stachydis kouyangensis 6 parts, 3 parts, ferrum rice, Cortex Ponciri trifoliatae 6 parts, Diplazium lanceum (Thunb) 3 Fen, Herba Polygoni Avicularis 6 parts, Semen Litchi 6 parts, Flos Magnoliae Amoenae 6 parts, Herba Dracocephali 6 parts, Gecko 1 part, Folium et Ramulus Callicarpae nudiflorae 3 parts, Fructus Setariae Germinatus (parched to brown) 10 parts.
Embodiment 3, crude drug weight proportion: Herba Selaginellae 20 parts, Herba stachydis kouyangensis 10 parts, 6 parts, ferrum rice, Cortex Ponciri trifoliatae 10 parts, Diplazium lanceum (Thunb) 6 Fen, Herba Polygoni Avicularis 10 parts, Semen Litchi 10 parts, Flos Magnoliae Amoenae 10 parts, Herba Dracocephali 10 parts, Gecko 2 parts, Folium et Ramulus Callicarpae nudiflorae 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.
Embodiment 4, crude drug weight proportion: Herba Selaginellae 30 parts, Herba stachydis kouyangensis 12 parts, 10 parts, ferrum rice, Cortex Ponciri trifoliatae 12 parts, Diplazium lanceum (Thunb) 10 Fen, Herba Polygoni Avicularis 12 parts, Semen Litchi 12 parts, Flos Magnoliae Amoenae 12 parts, Herba Dracocephali 12 parts, Gecko 5 parts, Folium et Ramulus Callicarpae nudiflorae 10 parts, Fructus Setariae Germinatus (parched to brown) 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Semen Litchi, Herba stachydis kouyangensis, Diplazium lanceum (Thunb) coarse powder are extracted volatile oil 6 hours with vapor distillation after soaking 4 hours separately, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Herba Selaginellae, ferrum rice, Cortex Ponciri trifoliatae, Herba Polygoni Avicularis, Flos Magnoliae Amoenae, Herba Dracocephali, Folium et Ramulus Callicarpae nudiflorae and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, mix subpackage and get final product.
The efficient combination of said medicine, coordinates mutually, effectively reach the object for the treatment of alcoholic cardiomyopathy, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
Case selection: in JIUYUE, 2010 ~ 2013 to be diagnosed as alcoholic cardiomyopathy year March and to occur together arrhythmia 79 example, wherein male 71 example, women 8 example, 36 ~ 62 years old age, 44 ± 5 years old mean age, the clinical manifestation of patient and lab testing all meet the suggestion that working group of community of International Society of Cardiology defines about alcoholic cardiomyopathy and classifies: the excessive drinking history 1. having more than 10 years, has the clinical manifestation of congestive heart failure; 2. take the photograph ethanol amount day and be greater than 125 g; 3. other heart diseases such as coronary heart disease, hypertension, congenital heart disease, viral myocarditis, valvular heart disease can be got rid of.Wherein atrial premature beat 45 example, paroxysmal supraventricular tachycardia 2 example, premature atrioventricular junctional beat 24 example, premature ventricular beat 7 example, Paroxysmal Atrial Fibrillation 3 example.79 routine patients are divided into three groups at random: matched group 25 example, decoction group 25 example, granule group 29 example.Compare on sex, age, the arrhythmia state of an illness, cardiac function before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method
1.2.1 Therapeutic Method: smoker actively gives up smoking, mandatory alleviating alcohol addiction and lie up, oxygen therapy.Matched group: give normal saline 100ml+ adenosine cyclophosphate 100mg, 10% glucose 500ml+ potassium chloride 1.5g+insulin 12 units+magnesium sulfate 1.0g, according to state of an illness choice for use diuretic, cardiac tonic (low dose), vasodilator, ACEI, beta receptor blocking agent (rear application is stablized in the treatment such as cardiac function 4 grades of person's heart tonifying, diuresis).Decoction group adds with embodiment 1 gained decoction on matched group medication basis, 2 times/d.Granule group adds with embodiment 3 gained granule on the basis of matched group medication, 10g/ time, 2 times/d.Three groups of courses for the treatment of are 2 months.
1.2.2 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups for the treatment of Plasma Before And After changes of Catecholamine Content measure and compare: catecholamine comprises norepinephrine and epinephrine, catecholamine concentration is clearly relevant to alcoholic cardiomyopathy arrhythmia episode, and the norepinephrine before and after three groups of treatments and epinephrine contents are shown in Table 2.
| Group | Number of cases | Norepinephrine | （pg/ml） | Epinephrine | （pg/ml） |
| Before treatment | After treatment | Before treatment | After treatment | ||
| Matched group | 25 | 585.3±236.0 | 444.1±129.4 | 284.1±134.6 | 216.3±91.5 |
| Decoction group | 25 | 596.2±222.6 | 341.4±124.3 | 246.4±124.4 | 141.4±89.4 |
| Granule group | 29 | 616.2±272.6 | 345.4±109.3 | 299.2±147.7 | 123.3±83.3 |
Result shows, Noradrenaline Contents after three groups of treatments obviously declines (matched group P<0.05, decoction group and granule group P<0.01), compare with time point after treatment, decoction group and granule group are starkly lower than matched group (P<0.05).Epinephrine contents after three groups of treatments obviously declines (three groups of equal P<0.05), and compare with time point after treatment, decoction group and granule group are starkly lower than matched group (P<0.05).
After 2.2 3 groups of treatments, a situation arises for 2m time point arrhythmia: 24 hr Ambulatory EKG Monitoring check results show, after treatment 2m, matched group has 52.00%(13/25 example), decoction group 24.00%(6/25 example), granule group 24.14%(7/29 example) patient still has arrhythmia conditions to occur, decoction group and granule group compare with matched group, have notable difference (P<0.05).
2.3 3 groups of adverse reactions of patients incidence rates compare: three groups all do not occur obvious adverse reaction record.
3. conclusion.
This result of study shows, decoction group of the present invention and granule group arrhythmia situation of correcting of taking obviously is better than matched group, and more effectively can reduce plasma Catecholamine Content, illustrate that pharmaceutical composition prepared by the inventive method has the lighter advantage of good effect, untoward reaction in treatment alcoholic cardiomyopathy.
Claims (1)
1. treat the preparation method of alcoholic cardiomyopathy arrhythmia granule for one kind, it is characterized in that, crude drug: Herba Selaginellae 10 ~ 30 parts, Herba stachydis kouyangensis 6 ~ 12 parts, 3 ~ 10 parts, ferrum rice, Cortex Ponciri trifoliatae 6 ~ 12 parts, Diplazium lanceum (Thunb) 3 ~ 10 Fen, Herba Polygoni Avicularis 6 ~ 12 parts, Semen Litchi 6 ~ 12 parts, Flos Magnoliae Amoenae 6 ~ 12 parts, Herba Dracocephali 6 ~ 12 parts, Gecko 1 ~ 5 part, Folium et Ramulus Callicarpae nudiflorae 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts; Be made up of following steps:
(1) Semen Litchi, Herba stachydis kouyangensis, Diplazium lanceum (Thunb) coarse powder are extracted volatile oil 6 hours with vapor distillation after soaking 4 hours separately, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;
(3) by gained medicinal residues mixing in Herba Selaginellae, ferrum rice, Cortex Ponciri trifoliatae, Herba Polygoni Avicularis, Flos Magnoliae Amoenae, Herba Dracocephali, Folium et Ramulus Callicarpae nudiflorae and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;
(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing loads granule, to obtain final product.
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| CN201510274932.XA CN104825897A (en) | 2013-11-09 | 2013-11-09 | Preparation method of therapeutic medicament for alcoholic myocardiopathy |
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| CN102836318A (en) * | 2012-09-22 | 2012-12-26 | 林燕 | Washing liquid for gardnerella vaginitis |
| CN103041184A (en) * | 2012-12-29 | 2013-04-17 | 青岛恒波仪器有限公司 | Traditional Chinese medicine composition for external use for curing chronic eczema of children and preparation method thereof |
| CN103223061A (en) * | 2013-04-28 | 2013-07-31 | 秦晓飞 | External application bedsore drug and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836318A (en) * | 2012-09-22 | 2012-12-26 | 林燕 | Washing liquid for gardnerella vaginitis |
| CN103041184A (en) * | 2012-12-29 | 2013-04-17 | 青岛恒波仪器有限公司 | Traditional Chinese medicine composition for external use for curing chronic eczema of children and preparation method thereof |
| CN103223061A (en) * | 2013-04-28 | 2013-07-31 | 秦晓飞 | External application bedsore drug and preparation method thereof |
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