CN104225227A - Particles for treating coronary heart disease and stenocardia - Google Patents

Abstract

The invention provides particles for treating coronary heart disease and stenocardia. The particles comprise the following raw medicine materials: pubescent holly root, morinda officinalis, pollen typhae, trichosanthes kirilowii maxim, rhizoma polygonati, hawthorn fruits, acanthopanax, gorgon fruits, platycodon grandiflorum, herba ecliptae, radix puerariae, radix ophiopogonis, red paeony root, lesser chickweed, companumoea root, assorted Chinese herbal tea, myrrh, aleppo avens, lousewort root, longan aril and valeriana hardwickii. The particles for treating coronary heart disease and stenocardia have good curative effects and have the functions of remarkably relieving symptoms of patients, improving stenocardia strength, reducing morbidity; the electrocardiograms of the patients show that the stenocardia is greatly improved; the obvious adverse effects are avoided during treating and after treating.

Description

Guanxintong granule

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Guanxintong granule being used for the treatment of angina pectoris.

Background technology

Angina pectoris is a kind of cardiovascular disease of serious harm human body health, the ictal chest pain because coronary atherosclerosis and the functional change of coronary artery (spasm) cause myocardium transient ischemic anoxia and cause or the uncomfortable clinical syndrome for main manifestations of chest, main in squeezing property pain, left shoulder can be radiated to, left arm is until finger tips, pain even involves back, the outbreak persistent period is shorter, be generally 1 ~ 5min, rarely exceed 15min, rest or buccal nitroglycerin can be alleviated, many because of fatigue, heavy meal, excited, environmental change etc. and bringing out, during outbreak, patient's pale complexion, expression is painful, even can there is the performance that cold sweat goes out.Coronary heart disease at present at the sickness rate of China in ascendant trend year by year, the Health and Living of the people in serious harm.

The first-selected nitrate esters medicine of the Drug therapy of this disease, also can use medicament for expanding vascellum, the antiplatelet drug such as aspirin, clopidogrel, or with conventional treatment drug such as beta-receptor blockader, fat regulation medicines.But conditions of patients easily occurs recurrence after these Drug therapys, correction patient ECG ischemic change situation is not remarkable.

Chinese medicine has the feature of Mutiple Targets, too many levels, multi-level, multi-faceted, multiaction approach, previously many from antioxidation, improve the aspects such as microcirculation, coronary artery dilator, increase blood flow and study, and to intervene inflammatory reaction, immunologic dysfunction be one of Hot Contents of current research.This disease belongs to Chinese medicine " thoracic obstruction " category.Clinical manifestation is chest pain, uncomfortable in chest, cardiopalmus etc., and its sickness rate, mortality rate rise year by year.Primary disease is the card of deficiency in origin and excess in superficiality, and real is that the stagnation of QI, blood stasis, cold coagulation, expectorant are turbid, stagnated chest-YANG, stagnating heart meridian; Void is liver, the heart, spleen, deficiency of the kidney void, and heart arteries and veins loses supports.The not outer disorder of emotion of the cause of disease, improper diet, inward invasion of pathogenic cold, aged debility etc.Confirmed by a series of meta-analysis research, in the generation evolution of cardiovascular disease, incubative pathogen (latent phlegm, the volt stasis of blood) is the pathological state existed from start to finish, observed by clinical practice, the dependency of expectorant stasis of blood volt network and cardiovascular disease chain is the closest, is the important factor affecting prognosis of disease, and the main mechanism that conduction occurs cardiovascular each disease is then expectorant stasis of blood volt network, its sick position is at channels, relevant to the five internal organs.The heresy of the expectorant stasis of blood, lying prostrate in blood network is the important target for the treatment of cardiovascular disease.The deficiency of vital energy, the stagnation of QI are that it essential condition of development occurs, expectorant stasis of blood incubative pathogen, and characteristic of disease belongs to cloudy, checks mechanism of qi, rapid wear yang-energy, forms stagnation and deficiency of QI, the card of expectorant stasis of blood volt network.Therefore, should with supplementing QI and nourishing YIN in treatment, blood circulation promoting and blood stasis dispelling is principle.The present invention is exactly that the one provided on the basis of this Therapeutic Principle is used for the treatment for the treatment of coronary heart disease and angina pectoris.

Summary of the invention

Technical problem to be solved by this invention is to provide one and is used for the treatment for the treatment of coronary heart disease and angina pectoris, its good effect, remarkable alleviation patient symptom, improve angina pectoris intensity, reduce attack times, and patient ECG's performance have also been obtained fine improvement, there will not be obvious adverse reaction in therapeutic process and after treatment.

For solving the problems of the technologies described above, the invention provides one and be used for the treatment for the treatment of coronary heart disease and angina pectoris, be called Guanxintong granule, its crude drug comprises Radix Ilicis Pubescentis, Radix Morindae Officinalis, Pollen Typhae, Fructus Trichosanthis, Rhizoma Polygonati, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Radix Platycodonis, Herba Ecliptae, Radix Puerariae, Radix Ophiopogonis, Radix Paeoniae Rubra, Herba Stellariae Alsines, Radix Campanumoeae, assorted Chinese medicine tea, Myrrha, Radix seu Herba Gei aleppici, Radix Pedicularis Henryi, Arillus Longan and Radix et Rhizoma Iridis Sanguineae.

In described medicine, the weight of each raw material is respectively Radix Ilicis Pubescentis 30g ~ 40g, Radix Morindae Officinalis 40g ~ 50g, Pollen Typhae 25g ~ 35g, Fructus Trichosanthis 20g ~ 30g, Rhizoma Polygonati 40g ~ 50g, Fructus Crataegi 20g ~ 30g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Semen Euryales 30g ~ 40g, Radix Platycodonis 20g ~ 30g, Herba Ecliptae 35g ~ 45g, Radix Puerariae 20g ~ 30g, Radix Ophiopogonis 20g ~ 30g, Radix Paeoniae Rubra 15g ~ 25g, Herba Stellariae Alsines 20g ~ 30g, Radix Campanumoeae 35g ~ 45g, assorted Chinese medicine tea 20g ~ 30g, Myrrha 25g ~ 35g, Radix seu Herba Gei aleppici 35g ~ 45g, Radix Pedicularis Henryi 20g ~ 30g, Arillus Longan 20g ~ 30g and Radix et Rhizoma Iridis Sanguineae 15g ~ 25g.

Further, in described medicine, the weight of each raw material is respectively Radix Ilicis Pubescentis 32g ~ 38g, Radix Morindae Officinalis 42g ~ 48g, Pollen Typhae 27g ~ 33g, Fructus Trichosanthis 22g ~ 28g, Rhizoma Polygonati 42g ~ 48g, Fructus Crataegi 22g ~ 28g, Radix Et Caulis Acanthopanacis Senticosi 27g ~ 33g, Semen Euryales 32g ~ 38g, Radix Platycodonis 22g ~ 28g, Herba Ecliptae 37g ~ 43g, Radix Puerariae 22g ~ 28g, Radix Ophiopogonis 22g ~ 28g, Radix Paeoniae Rubra 17g ~ 23g, Herba Stellariae Alsines 22g ~ 28g, Radix Campanumoeae 37g ~ 43g, assorted Chinese medicine tea 22g ~ 28g, Myrrha 27g ~ 33g, Radix seu Herba Gei aleppici 37g ~ 43g, Radix Pedicularis Henryi 22g ~ 28g, Arillus Longan 22g ~ 28g and Radix et Rhizoma Iridis Sanguineae 17g ~ 23g.

Most preferably, in described medicine the weight of each raw material be respectively Radix Ilicis Pubescentis 35g, Radix Morindae Officinalis 45g, Pollen Typhae 30g, Fructus Trichosanthis 25g, Rhizoma Polygonati 45g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 30g, Semen Euryales 35g, Radix Platycodonis 25g, Herba Ecliptae 40g, Radix Puerariae 25g, Radix Ophiopogonis 25g, Radix Paeoniae Rubra 20g, Herba Stellariae Alsines 25g, Radix Campanumoeae 40g, assorted Chinese medicine tea 25g, Myrrha 30g, Radix seu Herba Gei aleppici 40g, Radix Pedicularis Henryi 25g, Arillus Longan 25g and Radix et Rhizoma Iridis Sanguineae 20g.

Present invention also offers the preparation method of said medicine, it comprises:

The first step, Radix Morindae Officinalis, Pollen Typhae, Rhizoma Polygonati, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Herba Ecliptae, Radix Ophiopogonis, Radix Paeoniae Rubra, Herba Stellariae Alsines, Radix Campanumoeae, assorted Chinese medicine tea, Myrrha, Radix seu Herba Gei aleppici, Radix Pedicularis Henryi and Radix et Rhizoma Iridis Sanguineae are pulverized respectively, mix according to above-mentioned weight, stir, mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 45 degree ~ 55 degree, sealing immersion 5 ~ 10 days, boil 1 hour ~ 3 hours subsequently, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverizes and drying, obtain the first powder, filtering residue is for subsequent use;

Second step, pulverizes respectively by component under She, mixes according to above-mentioned weight, add the filtering residue that the first step is left over, stir 20 minutes ~ 40 minutes, obtain mixture, being dissolved in determining alcohol is in the ethanol of 85% ~ 95%, and the addition of the ethanol that every 100g mixture is corresponding is 300g, floods 20 hours ~ 30 hours, adopt percolation with the speed of 2 ~ 4ml per minute slowly percolation subsequently, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and drying, is obtained the second powder;

3rd step, by the first powder and the second powder Homogeneous phase mixing, obtains mixture; get 1kg mixture; add 1kg dextrin, 25g aspartame, be placed in wet granulator, be dry mixed 3 ~ 8 minutes; adding determining alcohol is 50% ~ 60% ethanol; granulate 2 ~ 5 minutes, dry, obtained described granule; splitting splendid attire, every bag of 5g.

Beneficial effect of the present invention:

Provided by the inventionly be used for the treatment for the treatment of coronary heart disease and angina pectoris Guanxintong granule good effect, remarkable alleviation patient symptom, improve angina pectoris intensity, reduce attack times, and patient ECG's performance have also been obtained fine improvement, there will not be obvious adverse reaction in therapeutic process and after treatment.

Detailed description of the invention

The invention provides one and be used for the treatment for the treatment of coronary heart disease and angina pectoris, be called Guanxintong granule, its crude drug comprises Radix Ilicis Pubescentis, Radix Morindae Officinalis, Pollen Typhae, Fructus Trichosanthis, Rhizoma Polygonati, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Radix Platycodonis, Herba Ecliptae, Radix Puerariae, Radix Ophiopogonis, Radix Paeoniae Rubra, Herba Stellariae Alsines, Radix Campanumoeae, assorted Chinese medicine tea, Myrrha, Radix seu Herba Gei aleppici, Radix Pedicularis Henryi, Arillus Longan and Radix et Rhizoma Iridis Sanguineae.

Further, described Guanxintong granule is only made up of above-mentioned raw materials medicine.

In described medicine, the weight of each raw material is respectively Radix Ilicis Pubescentis 30g ~ 40g, Radix Morindae Officinalis 40g ~ 50g, Pollen Typhae 25g ~ 35g, Fructus Trichosanthis 20g ~ 30g, Rhizoma Polygonati 40g ~ 50g, Fructus Crataegi 20g ~ 30g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Semen Euryales 30g ~ 40g, Radix Platycodonis 20g ~ 30g, Herba Ecliptae 35g ~ 45g, Radix Puerariae 20g ~ 30g, Radix Ophiopogonis 20g ~ 30g, Radix Paeoniae Rubra 15g ~ 25g, Herba Stellariae Alsines 20g ~ 30g, Radix Campanumoeae 35g ~ 45g, assorted Chinese medicine tea 20g ~ 30g, Myrrha 25g ~ 35g, Radix seu Herba Gei aleppici 35g ~ 45g, Radix Pedicularis Henryi 20g ~ 30g, Arillus Longan 20g ~ 30g and Radix et Rhizoma Iridis Sanguineae 15g ~ 25g.

Further, in described medicine, the weight of each raw material is respectively Radix Ilicis Pubescentis 32g ~ 38g, Radix Morindae Officinalis 42g ~ 48g, Pollen Typhae 27g ~ 33g, Fructus Trichosanthis 22g ~ 28g, Rhizoma Polygonati 42g ~ 48g, Fructus Crataegi 22g ~ 28g, Radix Et Caulis Acanthopanacis Senticosi 27g ~ 33g, Semen Euryales 32g ~ 38g, Radix Platycodonis 22g ~ 28g, Herba Ecliptae 37g ~ 43g, Radix Puerariae 22g ~ 28g, Radix Ophiopogonis 22g ~ 28g, Radix Paeoniae Rubra 17g ~ 23g, Herba Stellariae Alsines 22g ~ 28g, Radix Campanumoeae 37g ~ 43g, assorted Chinese medicine tea 22g ~ 28g, Myrrha 27g ~ 33g, Radix seu Herba Gei aleppici 37g ~ 43g, Radix Pedicularis Henryi 22g ~ 28g, Arillus Longan 22g ~ 28g and Radix et Rhizoma Iridis Sanguineae 17g ~ 23g.

Most preferably, in described medicine the weight of each raw material be respectively Radix Ilicis Pubescentis 35g, Radix Morindae Officinalis 45g, Pollen Typhae 30g, Fructus Trichosanthis 25g, Rhizoma Polygonati 45g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 30g, Semen Euryales 35g, Radix Platycodonis 25g, Herba Ecliptae 40g, Radix Puerariae 25g, Radix Ophiopogonis 25g, Radix Paeoniae Rubra 20g, Herba Stellariae Alsines 25g, Radix Campanumoeae 40g, assorted Chinese medicine tea 25g, Myrrha 30g, Radix seu Herba Gei aleppici 40g, Radix Pedicularis Henryi 25g, Arillus Longan 25g and Radix et Rhizoma Iridis Sanguineae 20g.

Radix Ilicis Pubescentis: mildly bitter flavor, sweet, property is put down, and returns lung, liver, large intestine channel, has heat-clearing and toxic substances removing, and effect of blood circulation and channel invigorating, cures mainly anemopyretic cold, dyspnea and cough due to lung-heat, laryngeal edema, tonsillitis, dysentery Radix Ilicis Pubescentis medicine disease, coronary heart disease, the hemiplegia caused by cerebrovas-cularaccident, thromboangiitis obliterans, erysipelas, scalds, central serous chorioretinopathy, uveitis, and skin acute suppurative inflammation.For coronary atherosclerotic heart disease, acute myocardial infarction, blood post thromboangiitis obliterans; The cards such as burn is controlled in external, chilblain.

Radix Morindae Officinalis: acrid in the mouth, sweet, warm in nature, returns liver, kidney channel, has reinforcing the kidney and supporting YANG; Bone and muscle strengthening; Effect of expelling wind and removing dampness, cures mainly impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; The cards such as rheumatism limb gas.

Pollen Typhae: sweet in the mouth, property is put down, and enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.

Fructus Trichosanthis: sweet in the mouth, micro-hardship, cold in nature, enter lung, stomach, large intestine channel, there is removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, effect of loosening bowel to relieve constipation, for cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, the cards such as acute appendicitis swells and ache, constipation, Fructus Trichosanthis has certain antitumaous effect.

Rhizoma Polygonati: latin name Polygonati Rhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, be mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi be the staple for the treatment of dyspepsia, and Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; To dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc., there is obvious inhibitory action, the effect that the effective ingredient Fructus Crataegi total flavones in Fructus Crataegi and Fructus Crataegi total triterpene acids have good blood fat reducing, reduce cholesterol, increase Gastric juice digestion enzyme.

Radix Et Caulis Acanthopanacis Senticosi: be the root of studies on plants of Acanthopanax Miq. in Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf, latin name Acanthopanacis Senticosi Radix et Rhizomaseu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.

Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.

Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature, enters lung meridian, has effect of expelling phlegm for arresting cough, lung qi dispersing evacuation of pus, cures mainly the cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.

Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell caused by the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Be suitable for the deficiency of YIN and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.

Radix Puerariae: latin name Puerariae Lobatae Radix, sweet in the mouth, pungent, cool in nature, enter spleen, stomach warp, have inspiration gastric qi, clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, and raw sun, oozes the effect of rash, be mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, and calentura is thirsty, quenches one's thirst; Diarrhea due to hypofunction of the spleen, the cards such as clear YANG failing to ascend.

Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire, and for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, the cards such as dryness of the intestine constipation.

Radix Paeoniae Rubra: bitter in the mouth, micro-hardship, returns Liver Channel, has removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cure mainly the conjunctival congestion and swelling pain of high liver fire, have a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, and macule is hemorrhage, and blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Various pain caused by blood retardance; The cards such as the furuncle carbuncle of heat in blood poison Sheng.

Herba Stellariae Alsines: be the herb of Caryophyllaceae Stellaria plant Stellaria alsine Grim., acrid in the mouth, property is put down, and returns lung, spleen channel, has expelling wind and removing dampness, promoting blood circulation and detumescence, and effect of removing toxic substances hemostasis, cures mainly flu, dysentery, rheumatic arthralgia, traumatic injury, venom, spits blood, the cards such as traumatic hemorrhage.

Radix Campanumoeae: latin name radix campanumoea javanicae is the root of campanulaceae leopard platymiscium Campanumoea javanica and leopard, sweet in the mouth, property is put down, and returns lung, spleen channel, has invigorating the spleen and benefiting QI, tonifying the lung and stopping cough, effect of stimulating milk secretion, cure mainly the empty internal injury of labor, the deficiency of vital energy is weak, cardiopalmus, hyperhidrosis, diarrhea due to hypofunction of the spleen, leucorrhea, milk is rare, the cards such as insufficiency of the spleen cough.

Assorted Chinese medicine tea: bitter in the mouth, pungent, cold nature, has blood stasis dispelling regulating menstruation, and effect of removing obstruction in the collateral to relieve pain cures mainly the cards such as menoxenia, puerperal abdonimal pain, treating swelling and pain by traumatic injury, hemiplegia.

Myrrha: bitter in the mouth, pungent, property is put down, and enters liver, spleen, the heart, kidney channel, has effect of promoting blood circulation and stopping pain, detumescence and promoting granulation, cure mainly the cards such as breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.

Radix seu Herba Gei aleppici: latin name Gei Herba, acrid in the mouth, hardship, property is put down, and return liver, spleen, lung meridian, have analgesia, blood pressure lowering, regulating menstruation, effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison is controlled in external, the cards such as traumatic injury.

Radix Pedicularis Henryi: be the root of Scrophulariaceae lousewort plant Heng Shi Radix seu Herba Pedicularis or long shoot Radix seu Herba Pedicularis, sweet in the mouth, micro-hardship, slightly warm in nature, has and fill blood, bone and muscle strengthening, effect of strengthening the spleen and stomach.Cure mainly dizziness and tinnitus, palpitation and short breath, brothers wither soft, bones and muscles pain, bronchitis, children's's food stagnation, the cards such as malnutrition.

Arillus Longan: warm in nature, taste is sweet, has invigorating the heart and spleen, effect of nourishing blood to tranquillize the mind, for cards such as insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.

Radix et Rhizoma Iridis Sanguineae: acrid in the mouth, sweet, property is put down, and have promoting blood flow to regulate menstruation, expelling wind and removing dampness, effect of spleen invigorating removing food stagnancy, cures mainly menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, treating swelling and pain by traumatic injury, dysuria, infantile malnutrition, the cards such as vasculitis.

Present invention also offers the preparation method of said medicine, it comprises:

The first step, Radix Morindae Officinalis, Pollen Typhae, Rhizoma Polygonati, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Herba Ecliptae, Radix Ophiopogonis, Radix Paeoniae Rubra, Herba Stellariae Alsines, Radix Campanumoeae, assorted Chinese medicine tea, Myrrha, Radix seu Herba Gei aleppici, Radix Pedicularis Henryi and Radix et Rhizoma Iridis Sanguineae are pulverized respectively, mix according to above-mentioned weight, stir, mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 45 degree ~ 55 degree, sealing immersion 5 ~ 10 days, boil 1 hour ~ 3 hours subsequently, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverizes and drying, obtain the first powder, filtering residue is for subsequent use;

Second step, pulverizes respectively by component under She, mixes according to above-mentioned weight, add the filtering residue that the first step is left over, stir 20 minutes ~ 40 minutes, obtain mixture, being dissolved in determining alcohol is in the ethanol of 85% ~ 95%, and the addition of the ethanol that every 100g mixture is corresponding is 300g, floods 20 hours ~ 30 hours, adopt percolation with the speed of 2 ~ 4ml per minute slowly percolation subsequently, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and drying, is obtained the second powder;

3rd step, by the first powder and the second powder Homogeneous phase mixing, obtains mixture; get 1kg mixture; add 1kg dextrin, 25g aspartame, be placed in wet granulator, be dry mixed 3 ~ 8 minutes; adding determining alcohol is 50% ~ 60% ethanol; granulate 2 ~ 5 minutes, dry, obtained described granule; splitting splendid attire, every bag of 5g.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 Guanxintong granule 1

By Radix Morindae Officinalis 45g, Pollen Typhae 30g, Rhizoma Polygonati 45g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 30g, Semen Euryales 35g, Herba Ecliptae 40g, Radix Ophiopogonis 25g, Radix Paeoniae Rubra 20g, Herba Stellariae Alsines 25g, Radix Campanumoeae 40g, assorted Chinese medicine tea 25g, Myrrha 30g, Radix seu Herba Gei aleppici 40g, Radix Pedicularis Henryi 25g and Radix et Rhizoma Iridis Sanguineae 20g pulverizes respectively, and mixing, stirs, mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 50 degree, sealing immersion 8 days, boils 2 hours subsequently, leaves standstill 12 hours, filter, the filtrate obtained is concentrated into removes all Chinese liquor, pulverizes and drying, obtains the first powder, filtering residue is for subsequent use, by Radix Ilicis Pubescentis 35g, Fructus Trichosanthis 25g, Radix Platycodonis 25g, Radix Puerariae 25g and Arillus Longan 25g pulverizes respectively, mixing, add the filtering residue left over above, stir 30 minutes, obtain mixture, being dissolved in determining alcohol is in the ethanol of 90%, the addition of the ethanol that every 100g mixture is corresponding is 300g, floods 25 hours, adopts percolation with the speed of 3ml per minute slowly percolation subsequently, collect percolate, percolate hold over night, filters, and filtrate is except desolventizing, pulverize and drying, obtain the second powder, by the first powder and the second powder Homogeneous phase mixing, obtain mixture, get 1kg mixture, add 1kg dextrin, 25g aspartame, is placed in wet granulator, is dry mixed 5 minutes, and adding determining alcohol is 60% ethanol, granulates 3 minutes, dry, obtained described granule, splitting splendid attire, and every bag of 5g, obtains Guanxintong granule 1.

Embodiment 2 Guanxintong granule 2

By Radix Morindae Officinalis 42g, Pollen Typhae 27g, Rhizoma Polygonati 42g, Fructus Crataegi 22g, Radix Et Caulis Acanthopanacis Senticosi 27g, Semen Euryales 32g, Herba Ecliptae 37g, Radix Ophiopogonis 22g, Radix Paeoniae Rubra 17g, Herba Stellariae Alsines 22g, Radix Campanumoeae 37g, assorted Chinese medicine tea 22g, Myrrha 27g, Radix seu Herba Gei aleppici 37g, Radix Pedicularis Henryi 22g and Radix et Rhizoma Iridis Sanguineae 17g pulverizes respectively, and mixing, stirs, mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 50 degree, sealing immersion 8 days, boils 2 hours subsequently, leaves standstill 12 hours, filter, the filtrate obtained is concentrated into removes all Chinese liquor, pulverizes and drying, obtains the first powder, filtering residue is for subsequent use, by Radix Ilicis Pubescentis 32g, Fructus Trichosanthis 22g, Radix Platycodonis 22g, Radix Puerariae 22g and Arillus Longan 22g pulverizes respectively, mixing, add the filtering residue left over above, stir 30 minutes, obtain mixture, being dissolved in determining alcohol is in the ethanol of 90%, the addition of the ethanol that every 100g mixture is corresponding is 300g, floods 25 hours, adopts percolation with the speed of 3ml per minute slowly percolation subsequently, collect percolate, percolate hold over night, filters, and filtrate is except desolventizing, pulverize and drying, obtain the second powder, by the first powder and the second powder Homogeneous phase mixing, obtain mixture, get 1kg mixture, add 1kg dextrin, 25g aspartame, is placed in wet granulator, is dry mixed 5 minutes, and adding determining alcohol is 60% ethanol, granulates 3 minutes, dry, obtained described granule, splitting splendid attire, and every bag of 5g, obtains Guanxintong granule 2.

Embodiment 3 Guanxintong granule 3

By Radix Morindae Officinalis 48g, Pollen Typhae 33g, Rhizoma Polygonati 48g, Fructus Crataegi 28g, Radix Et Caulis Acanthopanacis Senticosi 33g, Semen Euryales 38g, Herba Ecliptae 43g, Radix Ophiopogonis 28g, Radix Paeoniae Rubra 23g, Herba Stellariae Alsines 28g, Radix Campanumoeae 43g, assorted Chinese medicine tea 28g, Myrrha 33g, Radix seu Herba Gei aleppici 43g, Radix Pedicularis Henryi 28g and Radix et Rhizoma Iridis Sanguineae 23g pulverizes respectively, and mixing, stirs, mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 50 degree, sealing immersion 8 days, boils 2 hours subsequently, leaves standstill 12 hours, filter, the filtrate obtained is concentrated into removes all Chinese liquor, pulverizes and drying, obtains the first powder, filtering residue is for subsequent use, by Radix Ilicis Pubescentis 38g, Fructus Trichosanthis 28g, Radix Platycodonis 28g, Radix Puerariae 28g and Arillus Longan 28g pulverizes respectively, mixing, add the filtering residue left over above, stir 30 minutes, obtain mixture, being dissolved in determining alcohol is in the ethanol of 90%, the addition of the ethanol that every 100g mixture is corresponding is 300g, floods 25 hours, adopts percolation with the speed of 3ml per minute slowly percolation subsequently, collect percolate, percolate hold over night, filters, and filtrate is except desolventizing, pulverize and drying, obtain the second powder, by the first powder and the second powder Homogeneous phase mixing, obtain mixture, get 1kg mixture, add 1kg dextrin, 25g aspartame, is placed in wet granulator, is dry mixed 5 minutes, and adding determining alcohol is 60% ethanol, granulates 3 minutes, dry, obtained described granule, splitting splendid attire, and every bag of 5g, obtains Guanxintong granule 3.

Embodiment 4 toxicology test

1, acute toxicity test

Choose 30 kunming mices, thered is provided by Qingdao City's laboratory animal and animal experimental center, be divided into three groups, be respectively Guanxintong granule 1 group, Guanxintong granule 2 groups and Guanxintong granule 3 groups, the Guanxintong granule of oral administration gavage embodiments of the invention 1 to embodiment 3 preparation, by Guanxintong grain dissolution gavage in distilled water, under 1000g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine composition of the present invention is 1000g crude drug/kg/d (LD ₅₀> 1000g crude drug/kg).Point out this medicine acute toxicity extremely low, clinical drug safety.

2, chronic toxicity test report

Guanxintong granule 1 adding distil water embodiment 1 prepared dissolves, 10g crude drug/kg, 30g crude drug/kg and 60g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight is pressed to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.After Guanxintong granules in rats long-term prescription of the present invention is described, toxicity is little, does not also have difference reaction, application safety after drug withdrawal.

Embodiment 5 clinical data

Physical data

Case is in May, 2012 to 2013 year JIUYUE and shows effect in the medical patient of my Out-patient Department because of angina pectoris, and totally 180 examples, adopt the method grouping of random controls, treatment group 90 example, 43 ~ 71 years old age, average (56.19 ± 6.13) year; Matched group 90 example, 38 ~ 76 years old age, average (53.21 ± 8.33) year; The symptoms such as two groups of patients all have uncomfortable in chest, chest pain, cardiopalmus in various degree, breathe hard, dizzy.Treat front two groups of ages, height, body weight, heart rate, systolic pressure, diastolic pressure, sex, nationality, drug allergy history, previously treat all tool comparabilities (P > 0.05) such as history, routine blood test, hepatic and renal function, urine and stool routine and Electrocardioscopy.Except rejecting and coming off except case, two groups of case compliances all good (P > 0.05).

Diagnostic criteria

180 routine patients all meet " new Chinese medicine treatment angina pectoris guideline of clinical investigations " (3) and WHO " name and diagnostic criteria about ischemic heart desease " standard formulation in 1979.Include case standard in: 1, meet the diagnostic criteria of doctor trained in Western medicine angina pectoris, meet that exertional angina pectoris I, II, III level diagnostic criteria or noneffort angina are slight, moderate diagnostic criteria; Chinese medical discrimination is stagnation and deficiency of QI, phlegm-stasis in channels person.2, show effect weekly the patient of angina pectoris >=2 time.3, the ordinary electrocardiogram positive (making ordinary electrocardiogram while being included in angina pectoris attacks) has ischemic-type to change (ST section decline >=0.05mV and/or R ripple are taken connection T ripple as the leading factor and be inverted and dark > 0.2mV).4, Informed Consent Form is signed.

Therapeutic Method

Treatment group gives Guanxintong granule prepared by embodiment 1, and each 1 bag, every bag of 5g, every day 3 times, warm water takes.

Matched group gives isosorbide mononitrate sustained release tablets (Shandong Lunan Bei Te pharmaceutical Co. Ltd produces, lot number: H10940039), and each 1, every day 2 times, warm water takes after meal.Duration of test prohibits the use the Chinese and western drugs of other treatment angina pectoris except nitroglycerin, the course for the treatment of 28d.Take conventional buck medicine with hyperpietic, with glycosuria patient routine application antidiabetic drug, take lipid-lowering statins with hyperlipemia person.

Efficacy assessment standard

Formulate with reference to " guideline of clinical investigations of the new Chinese medicine treatment thoracic obstruction (angina pectoris) " and Angina Pectoris from Coronary Artery Disease with Therapy of Combination of TCM with Western Medicines in 1979 and arrhythmia forum " angina pectoris and ECG curative effect evaluation criteria ".Effective: the cardinal symptoms such as angina pectoris disappear or reach effective standard, electrocardiogram returns to normal ECG or reaches roughly normal (electrocardiogram normal range).Effective: the cardinal symptoms such as angina pectoris alleviate or reach effective standard, electrocardiogram improvement reaches effective standard.Invalid: the cardinal symptoms such as angina pectoris are without improvement, and electrocardiogram is substantially identical with before treatment.Increase the weight of: the cardinal symptoms such as angina pectoris and electrocardiogram increase the weight of before comparatively testing.

Tcm syndrome efficacy assessment standard: tcm syndrome therapeutic index N=(before (before treatment the rear integration of integration-treatment)/treatment integration) × 100%.Effective: therapeutic index >=70%, < 90%; Effective: therapeutic index >=30%, < 70%; Invalid: therapeutic index < 30%.Effective case load statistics total effective rate is added with effective.Nitroglycerin stops lapse rate: drug withdrawal: treat or withdraw completely.Decrement: after treatment, better prodrug reduces more than 50%.Constant: after treatment, drug dose reduces less than 50%.

Observation index

Two groups respectively before the treatment after itemized record Heart Rate, blood pressure, clinical symptoms (comprise uncomfortable in chest, cardiopalmus, breathe hard, weak, dizzy etc.), check blood, urine, feces routine examination, liver function (ALT), renal function (BUN, Cr) check.Observation of curative effect: 1. anginal number of times, pain degree, persistent period, induced factor, nitroglycerin dose and stop lapse rate (all genus with angina pectoris those selected, when evaluating angina pectoris attacks number of times, pain degree, persistent period before and after treatment, need carry out under equal activity).2. the change etc. of tcm symptom, picture of the tongue and pulse condition.3. electrocardiogram: carry out ordinary electrocardiogram inspection respectively before and after test.

Statistical method

Measurement data adopts represent, compare between group and adopt χ ²inspection, all data all adopt the process of SPSS12.0 statistical software.

Result

Two groups of angina pectoris comparitive study, in table 1.

Table 1 liang group angina pectoris comparitive study

Group	n	Effective	Effectively	Invalid	Increase the weight of	Total effective rate (%)
							Treatment group	90	46	37	7	0	92.2
Matched group	90	29	46	15	0	83.3

As can be seen from Table 1, Guanxintong good effect provided by the invention is adopted, P < 0.05.

Two groups of patient's tcm syndrome total effectses compare, and the results are shown in Table 2.

A table 2 liang group patient tcm syndrome total effects compares

Group	n	Effective	Effectively	Invalid	Total effective rate (%)
						Treatment group	90	51	35	4	95.5
Matched group	90	29	49	12	86.7

As can be seen from Table 2, Guanxintong good effect provided by the invention is adopted, P < 0.05.

Two groups of patient ECG's comparitive study, the results are shown in Table 3.

Table 3 liang group patient ECG comparitive study

Group	n	Effective	Effectively	Invalid	Increase the weight of	Total effective rate (%)
							Treatment group	90	43	41	6	0	93.3
Matched group	90	23	56	11	0	87.8

Untoward reaction

All patients whole patient before and after medication all carries out the safety indexes such as blood, urine, feces, liver function, kidney merit and detects, all do not exceed before and after indices treatment normal value ± 10% within, illustrates and tests medication use safety.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (5)

1. be used for the treatment of a treating coronary heart disease and angina pectoris Guanxintong granule, it is characterized in that: crude drug comprises Radix Ilicis Pubescentis, Radix Morindae Officinalis, Pollen Typhae, Fructus Trichosanthis, Rhizoma Polygonati, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Radix Platycodonis, Herba Ecliptae, Radix Puerariae, Radix Ophiopogonis, Radix Paeoniae Rubra, Herba Stellariae Alsines, Radix Campanumoeae, assorted Chinese medicine tea, Myrrha, Radix seu Herba Gei aleppici, Radix Pedicularis Henryi, Arillus Longan and Radix et Rhizoma Iridis Sanguineae.

2. Guanxintong granule as claimed in claim 1, it is characterized in that: the weight of each raw material is respectively Radix Ilicis Pubescentis 30g ~ 40g, Radix Morindae Officinalis 40g ~ 50g, Pollen Typhae 25g ~ 35g, Fructus Trichosanthis 20g ~ 30g, Rhizoma Polygonati 40g ~ 50g, Fructus Crataegi 20g ~ 30g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Semen Euryales 30g ~ 40g, Radix Platycodonis 20g ~ 30g, Herba Ecliptae 35g ~ 45g, Radix Puerariae 20g ~ 30g, Radix Ophiopogonis 20g ~ 30g, Radix Paeoniae Rubra 15g ~ 25g, Herba Stellariae Alsines 20g ~ 30g, Radix Campanumoeae 35g ~ 45g, assorted Chinese medicine tea 20g ~ 30g, Myrrha 25g ~ 35g, Radix seu Herba Gei aleppici 35g ~ 45g, Radix Pedicularis Henryi 20g ~ 30g, Arillus Longan 20g ~ 30g and Radix et Rhizoma Iridis Sanguineae 15g ~ 25g.

3. Guanxintong granule as claimed in claim 1 or 2, it is characterized in that: the weight of each raw material is respectively Radix Ilicis Pubescentis 32g ~ 38g, Radix Morindae Officinalis 42g ~ 48g, Pollen Typhae 27g ~ 33g, Fructus Trichosanthis 22g ~ 28g, Rhizoma Polygonati 42g ~ 48g, Fructus Crataegi 22g ~ 28g, Radix Et Caulis Acanthopanacis Senticosi 27g ~ 33g, Semen Euryales 32g ~ 38g, Radix Platycodonis 22g ~ 28g, Herba Ecliptae 37g ~ 43g, Radix Puerariae 22g ~ 28g, Radix Ophiopogonis 22g ~ 28g, Radix Paeoniae Rubra 17g ~ 23g, Herba Stellariae Alsines 22g ~ 28g, Radix Campanumoeae 37g ~ 43g, assorted Chinese medicine tea 22g ~ 28g, Myrrha 27g ~ 33g, Radix seu Herba Gei aleppici 37g ~ 43g, Radix Pedicularis Henryi 22g ~ 28g, Arillus Longan 22g ~ 28g and Radix et Rhizoma Iridis Sanguineae 17g ~ 23g.

4. the Guanxintong granule as described in claims 1 to 3, is characterized in that: the weight of each raw material be respectively Radix Ilicis Pubescentis 35g, Radix Morindae Officinalis 45g, Pollen Typhae 30g, Fructus Trichosanthis 25g, Rhizoma Polygonati 45g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 30g, Semen Euryales 35g, Radix Platycodonis 25g, Herba Ecliptae 40g, Radix Puerariae 25g, Radix Ophiopogonis 25g, Radix Paeoniae Rubra 20g, Herba Stellariae Alsines 25g, Radix Campanumoeae 40g, assorted Chinese medicine tea 25g, Myrrha 30g, Radix seu Herba Gei aleppici 40g, Radix Pedicularis Henryi 25g, Arillus Longan 25g and Radix et Rhizoma Iridis Sanguineae 20g.

5. the preparation method of the Guanxintong granule described in Claims 1-4, is characterized in that, comprising:

The first step, Radix Morindae Officinalis, Pollen Typhae, Rhizoma Polygonati, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Semen Euryales, Herba Ecliptae, Radix Ophiopogonis, Radix Paeoniae Rubra, Herba Stellariae Alsines, Radix Campanumoeae, assorted Chinese medicine tea, Myrrha, Radix seu Herba Gei aleppici, Radix Pedicularis Henryi and Radix et Rhizoma Iridis Sanguineae are pulverized respectively, mix according to above-mentioned weight, stir, mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 45 degree ~ 55 degree, sealing immersion 5 ~ 10 days, boil 1 hour ~ 3 hours subsequently, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverizes and drying, obtain the first powder, filtering residue is for subsequent use;

Second step, pulverizes respectively by component under She, mixes according to above-mentioned weight, add the filtering residue that the first step is left over, stir 20 minutes ~ 40 minutes, obtain mixture, being dissolved in determining alcohol is in the ethanol of 85% ~ 95%, and the addition of the ethanol that every 100g mixture is corresponding is 300g, floods 20 hours ~ 30 hours, adopt percolation with the speed of 2 ~ 4ml per minute slowly percolation subsequently, collect percolate, percolate hold over night, filter, filtrate, except desolventizing, is pulverized and drying, is obtained the second powder;

3rd step, by the first powder and the second powder Homogeneous phase mixing, obtains mixture; get 1kg mixture; add 1kg dextrin, 25g aspartame, be placed in wet granulator, be dry mixed 3 ~ 8 minutes; adding determining alcohol is 50% ~ 60% ethanol; granulate 2 ~ 5 minutes, dry, obtained described granule; splitting splendid attire, every bag of 5g.