CN102824619A - Pharmaceutical composition for treating ischemic cerebrovascular diseases and preparation method thereof - Google Patents
Pharmaceutical composition for treating ischemic cerebrovascular diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating ischemic cerebrovascular diseases and a preparation method thereof. The pharmaceutical composition for treating ischemic cerebrovascular diseases has effects of tonifying qi, nourishing yin, nourishing blood, removing blood stasis and dredging collaterals and is prepared from milkvetch root, tall gastrodia tuber, root of pilose asiabell, peach kernel, hawthorn fruit, tortoiseshell, prepared rehmannia root, suberect spatholobus stem, wolfberry, sichuan lovage rhizome, baked ginger and Chinese angelica. The pharmaceutical composition for treating ischemic cerebrovascular diseases can be added with conventional auxiliary materials and the mixture can be processed into tablets, particles, pills, capsules, a sustained release agent and an oral liquid by conventional processes.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, specifically, relate to a kind of pharmaceutical composition of treating ischemic cerebrovascular and preparation method thereof.
Background technology
Cerebrovascular disease is clinical commonly encountered diseases and frequently-occurring disease, and its mortality rate is high, disability rate is high, has brought white elephant for family and society.Ischemic cerebrovascular is the main cause of apoplexy, and about 85% apoplexy is ischemic, and the problem of the maximum that the patient of apoplexy survival faces is the generation with other ischemic incidents of reaccessing.Ischemic cerebrovascular is a kind of commonly encountered diseases clinically, is meant because the cerebrovascular that a variety of causes causes stops up, and causes the cerebrovascular function obstacle, causes relevant symptom, and like hemiplegia, speech is unfavorable, dizzy order tinnitus etc.
In recent years, China's medical circle is given full play to the advantage of Chinese medicine, and present existing medicine is all obtained general application in clinical practice, but present ubiquity weak effect in the medicine, owing to use insect medicine, it is big to take side effect for a long time more.Therefore, development effectiveness is remarkable, and the little medicine of side effect has very important significance to adapt to clinical needs.
Summary of the invention
The objective of the invention is to disclose a kind of pharmaceutical composition of treating ischemic cerebrovascular, the present invention also aims to the method for preparing of open said composition.
A kind of pharmaceutical composition of treating ischemic cerebrovascular involved in the present invention, it mainly is to be processed by the crude drug Radix Astragali, Rhizoma Gastrodiae, Radix Codonopsis, Semen Persicae, Fructus Crataegi, Carapax et Plastrum Testudinis, Radix Rehmanniae Preparata, Caulis Spatholobi, Fructus Lycii, Rhizoma Chuanxiong, Rhizoma Zingiberis Preparatum, Radix Angelicae Sinensis.
The card that prescription according to the invention cures mainly is by due to the venation block, and the Radix Astragali, Radix Codonopsis make the prosperous blood of gas capable with invigorating primordial QI; Chinese Angelica blood replonishing is aided with Rhizoma Chuanxiong to make strengthening spleen and nourishing blood; Rhizoma Gastrodiae is returned Liver Channel, endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral; Semen Persicae, Caulis Spatholobi and Fructus Crataegi return liver, blood circulation promoting and blood stasis dispelling collateral dredging, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm; Carapax et Plastrum Testudinis, Fructus Lycii and Radix Rehmanniae Preparata life essence-filling, marrow-benefitting, YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating; The Rhizoma Zingiberis Preparatum warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding, negative and positive are with mending.Full side share, and plays blood circulation promoting and blood stasis dispelling altogether, the effect of dredge the meridian passage.
Benefiting qi and nourishing yin of the present invention nourishes blood, eliminating blood stasis and smoothing collaterals.Stagnation of the stroke for the context, Zheng Jian hemiplegia, aphasia sound dumb, mouth askew, partial body numbness, shortness of breath, fatigue, palpitations, Koushi white, from sweating, foot swelling, loose stools, mouth drooling, tongue dim, greasy or scalloped tongue, thin pulse by.
The consumption of Chinese medicine composition of the present invention and drug component thereof is also groped to sum up to draw through the inventor in a large number
A kind of proportion of composing of treating the oral Chinese medicine compositions of apoplexy of described treatment comprises: Radix Astragali 6-12 part, Rhizoma Gastrodiae 5-10 part, Radix Codonopsis 5-10 part, Semen Persicae 5-10 part, Fructus Crataegi 5-8 part, Carapax et Plastrum Testudinis 4-8 part, Radix Rehmanniae Preparata 4-8 part, Caulis Spatholobi 4-8 part, Fructus Lycii 4-6 part, Rhizoma Chuanxiong 3-12 part, Rhizoma Zingiberis Preparatum 2-6 part, Radix Angelicae Sinensis 6-15 part.
A kind of further proportion of composing of treating the oral Chinese medicine compositions of apoplexy of described treatment comprises: Radix Astragali 10-12 part, Rhizoma Gastrodiae 8-10 part, Radix Codonopsis 6-8 part, Semen Persicae 6-8 part, Fructus Crataegi 5-6 part, Carapax et Plastrum Testudinis 5-6 part, Radix Rehmanniae Preparata 5-6 part, Caulis Spatholobi 5-6 part, Fructus Lycii 5-6 part, Rhizoma Chuanxiong 4-6 part, Rhizoma Zingiberis Preparatum 3-5 part, Radix Angelicae Sinensis 8-10 part.
A kind of preferred proportion of composing of treating the oral Chinese medicine compositions of apoplexy of described treatment comprises: 12 parts of the Radixs Astragali, 8 parts in Rhizoma Gastrodiae, 6 parts of Radix Codonopsis, 8 parts in Semen Persicae, 5 parts of Fructus Crataegis, 5 parts of Carapax et Plastrum Testudiniss, 5 parts in Radix Rehmanniae Preparata, 6 parts of Caulis Spatholobis, 6 parts of Fructus Lycii, 4 parts of Rhizoma Chuanxiongs, 4 parts of Rhizoma Zingiberis Preparatums, 8 parts of Radix Angelicae Sinensis.
A kind of preferred proportion of composing of treating the oral Chinese medicine compositions of apoplexy of described treatment can also comprise: 10 parts of the Radixs Astragali, 8 parts in Rhizoma Gastrodiae, 6 parts of Radix Codonopsis, 6 parts in peach, 6 parts of Fructus Crataegis, 6 parts of Carapax et Plastrum Testudiniss, 6 parts in Radix Rehmanniae Preparata, 6 parts of Caulis Spatholobis, 6 parts of Fructus Lycii, 6 parts of Rhizoma Chuanxiongs, 3 parts of Rhizoma Zingiberis Preparatums, 10 parts of Radix Angelicae Sinensis.
In a word, the present invention forms monarch, minister, it is various to help, make, and compatibility is rigorous, complements each other, and plays benefiting QI and nourishing blood altogether, the merit of eliminating blood stasis and smoothing collaterals.
Medicine of the present invention can add conventional adjuvant, according to common process, processes clinical acceptable tablet, granule, pill, capsule, slow releasing agent, oral liquid etc.
The method for preparing of medicine of the present invention comprises the steps: that above 12 flavors are ground into fine powder, sieves, and mixing, the system granule, drying, encapsulated.
The method for preparing of the tablet of medicine of the present invention comprises the steps: above 12 flavors, is ground into fine powder, sieve, and mixing, the system granule, drying, tabletting is processed tablet.
The method for preparing of the tablet of medicine of the present invention concentrates after comprising the steps: above 12 flavor decoctings, filters, and processes oral liquid.
Preparation of drug combination method of the present invention preferably includes following steps: above 12 flavors, Rhizoma Gastrodiae, Radix Codonopsis, Carapax et Plastrum Testudinis and Radix Angelicae Sinensis powder are broken into fine powder, sieve, and are condensed into the thick paste shape after all the other 8 flavor liquid medicine boil, and be with the mixed granule of above-mentioned fine powder, drying, encapsulated.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1
1, prescription:
Radix Astragali 12g, Rhizoma Gastrodiae 8g, Radix Codonopsis 6g, Semen Persicae 8g, Fructus Crataegi 5g, Carapax et Plastrum Testudinis 5g, Radix Rehmanniae Preparata 5g, Caulis Spatholobi 6g, Fructus Lycii 6g, Rhizoma Chuanxiong 4g, Rhizoma Zingiberis Preparatum 4g, Radix Angelicae Sinensis 8g.
2. method for making:
More than 12 the flavor be ground into fine powder, sieve, mixing, the system granule, drying, encapsulated, process 200, promptly get.
Embodiment 2
1, prescription:
Radix Astragali 10g, Rhizoma Gastrodiae 8g, Radix Codonopsis 6g, Semen Persicae 6g, Fructus Crataegi 6g, Carapax et Plastrum Testudinis 6g, Radix Rehmanniae Preparata 6g, Caulis Spatholobi 6g, Fructus Lycii 6g, Rhizoma Chuanxiong 6g, Rhizoma Zingiberis Preparatum 3g, Radix Angelicae Sinensis 10g.
2, technology:
More than 12 the flavor, be ground into fine powder, sieve, mixing, the system granule, drying, tabletting is processed 200, promptly gets.
Embodiment 3
1, prescription:
Radix Astragali 100g, Rhizoma Gastrodiae 80g, Radix Codonopsis 60g, Semen Persicae 60g, Fructus Crataegi 60g, Carapax et Plastrum Testudinis 60g, Radix Rehmanniae Preparata 60g, Caulis Spatholobi 60g, Fructus Lycii 60g, Rhizoma Chuanxiong 60g, Rhizoma Zingiberis Preparatum 30g, Radix Angelicae Sinensis 100g
2. method for making:
More than 12 flavors, Rhizoma Gastrodiae, Radix Codonopsis, Carapax et Plastrum Testudinis and Radix Angelicae Sinensis powder are broken into fine powder, sieve, all the other 8 flavor liquid medicine are condensed into the thick paste shape after boiling, and are encapsulated with the mixed granule of above-mentioned fine powder, drying, process 300, promptly get.
Embodiment 4
1, prescription:
Radix Astragali 110g, Rhizoma Gastrodiae 80g, Radix Codonopsis 70g, Semen Persicae 65g, Fructus Crataegi 50g, Carapax et Plastrum Testudinis 55g, Radix Rehmanniae Preparata 60g, Caulis Spatholobi 55g, Fructus Lycii 60g, Rhizoma Chuanxiong 45g, Rhizoma Zingiberis Preparatum 35g, Radix Angelicae Sinensis 85g.
2. method for making:
More than behind the 12 flavor decoctings, concentrate, filter, process oral liquid 100ml.
Embodiment 5 tests of pesticide effectiveness
[test material]
Receive the reagent thing: the collateral dredging blood nourishing granule: chocolate brown powder, the 0.4g/ grain is made by embodiment 3, is made into required concentration with preceding with distilled water.
Positive control drug: nimodipine, Tianjin Central Pharmaceutical Co., Ltd, lot number 2010050908
[test method and result]
1. to the protective effect of acute experiment property imperfection cerebral ischemia mice
Get 80 of IC R mices, male and female have both, and are divided into 5 groups at random.Model group: give isometric distilled water; Positive drug group: give nimodipine 40m g/kg, collateral dredging blood nourishing granule low dose group 2.4g/kg, collateral dredging blood nourishing granule high dose group 4.8g/kg; Oral successive administration 7 days; After 0.5 hour, dorsal position is fixed in the last administration, with cutting off in the middle of 0 trumpeter's art suture two ends ligation bilateral common carotid arteries (merging vagus nerve) back.The breathing of record mice is held time.
The result sees table 1.
Table 1 collateral dredging blood nourishing granule is to the protective effect of chmice acute cerebral ischemia
Annotate: compare with model group,
△P＜0.05,
△ △P＜0.01.
2. to the protective effect of middle cerebral artery ischemia-reperfusion rat due to suture method
Will long 40mm, an end of the nylon wire of diameter 0.2mm is heated to be slick sphere.Clean and with wipes of alcohol in 18.5mm place labelling apart from the pommel, place 0.9%NS subsequent use.The duplicating and divide into groups of intraluminal middle cerebral artery occlusion in rats ischemia-reperfusion injury model: get 70 of rats, be divided into 6 groups at random, except that 10 of sham operated rats, all the other 5 groups every group 15.Sham operated rats, model group: give isometric distilled water, the positive drug group: give nimodipine 20mg/kg, collateral dredging blood nourishing granule high dose group 4.8g/kg, collateral dredging blood nourishing granule low dose group 2.4g/kg.Each organizes oral successive administration 7 days, after 0.5 hour, uses 10% chloral hydrate in the last administration, 300m g/kg, intraperitoneal injection of anesthesia.Lie on the back on operating-table, neck medisection is separated left carotid (CCA), external carotid artery (ECA), and internal carotid artery (ICA) meets the branch of pricking and cutting off ECA with No. 0 line, separates the outer branch of the cranium pterygoid process arteria palatina of ICA.Folder closes CCA, ICA, and ready nylon embolus is inserted the people from ECA, goes into cranium to anterior cerebral artery (ACA) through the CCA crotch through ICA, and the nylon wire insertion depth is about 18mm.The blood that draws nylon wire that its pommel is back to when pouring into again outward can to recover middle cerebral artery in the ECA supplies.It is the same that sham operated rats is not inserted outer all the other steps of nylon wire.
Result of the test is seen table 2.
Table 2 collateral dredging blood nourishing granule is to the influence of ischemia-reperfusion rat brain index and brain water content
Annotate: compare with sham operated rats,
△P＜0.05,
△ △P＜0.01
Compare * p＜0.05, * * p＜0.01 with model group
This experimental result shows that cerebral index and brain water content that sermion tablet can obviously reduce the ischemia-reperfusion rat obviously prolong the breathing time that the ligation bilateral common carotid arteries causes acute incomplete cerebral ischemia mice.The expansible cerebrovascular of sermion tablet is described, is improved cerebral blood flow, improve brain function.
Embodiment 6 toxicity tests
[test material]
Receive the reagent thing: the collateral dredging blood nourishing granule: chocolate brown powder, the 0.4g/ grain is made by embodiment 3, is made into required concentration with preceding with distilled water.
[test method and result]
The used Kunming mouse 18 ± 2g of acute toxicity test, male and female half and half.Selection is bought this laboratory and is adapted to behind the 3d in good conditionly, and behavior, movable N/R animal experimentize.Fasting 14～16h before each animals administer, fasting 4h can't help water after the administration.Single gastric infusion during experiment, 40mL/kg, wherein the blank group waits the distilled water of capacity.Observe the response situation of animal after the administration; And the lasting 4h that observes; Observe 7d. acute toxicity test observation index continuously: observe animal body quality, diet, outward appearance, behavior, secretions, Excreta and poisoning symptom; The zero-time of toxic reaction, the order of severity, persistent period, the death condition of record animal, and respectively before administration the 3rd day (D3) after (D0), the administration, the 7th day (D7) claim the animal scale of construction.
In the administration 4h and in 1 week, the blank group is not seen obvious abnormal response, and all animals do not see death.The equal normal growth of each treated animal scale of construction, administration group and blank control group compare, the difference not statistically significant.This pharmaceutical composition safety non-toxic is described.
Claims (9)
1. pharmaceutical composition of treating ischemic cerebrovascular, the composition and the weight portion that it is characterized in that processing the crude drug of this medicine are: Radix Astragali 6-12 part, Rhizoma Gastrodiae 5-10 part, Radix Codonopsis 5-10 part, Semen Persicae 5-10 part, Fructus Crataegi 5-8 part, Carapax et Plastrum Testudinis 4-8 part, Radix Rehmanniae Preparata 4-8 part, Caulis Spatholobi 4-8 part, Fructus Lycii 4-6 part, Rhizoma Chuanxiong 3-12 part, Rhizoma Zingiberis Preparatum 2-6 part, Radix Angelicae Sinensis 6-15 part.
2. a kind of pharmaceutical composition of treating ischemic cerebrovascular according to claim 1, the composition and the weight portion that it is characterized in that processing the crude drug of this medicine are: Radix Astragali 10-12 part, Rhizoma Gastrodiae 8-9 part, Radix Codonopsis 6-8 part, Semen Persicae 6-8 part, Fructus Crataegi 5-6 part, Carapax et Plastrum Testudinis 5-6 part, Radix Rehmanniae Preparata 5-6 part, Caulis Spatholobi 5-6 part, Fructus Lycii 5-6 part, Rhizoma Chuanxiong 4-8 part, Rhizoma Zingiberis Preparatum 3-5 part, Radix Angelicae Sinensis 8-10 part.
3. a kind of pharmaceutical composition of treating ischemic cerebrovascular according to claim 2, the composition and the weight portion that it is characterized in that processing the crude drug of this medicine are 12 parts of the Radixs Astragali, 8 parts in Rhizoma Gastrodiae, 6 parts of Radix Codonopsis, 8 parts in Semen Persicae, 5 parts of Fructus Crataegis, 5 parts of Carapax et Plastrum Testudiniss, 5 parts in Radix Rehmanniae Preparata, 6 parts of Caulis Spatholobis, 6 parts of Fructus Lycii, 4 parts of Rhizoma Chuanxiongs, 4 parts of Rhizoma Zingiberis Preparatums, 8 parts of Radix Angelicae Sinensis.
4. a kind of pharmaceutical composition of treating ischemic cerebrovascular according to claim 2, the composition and the weight portion that it is characterized in that processing the crude drug of this medicine are 10 parts of the Radixs Astragali, 8 parts in Rhizoma Gastrodiae, 6 parts of Radix Codonopsis, 6 parts in Semen Persicae, 6 parts of Fructus Crataegis, 6 parts of Carapax et Plastrum Testudiniss, 6 parts in Radix Rehmanniae Preparata, 6 parts of Caulis Spatholobis, 6 parts of Fructus Lycii, 9 parts of Rhizoma Chuanxiongs, 3 parts of Rhizoma Zingiberis Preparatums, 10 parts of Radix Angelicae Sinensis.
5. like the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that getting crude drug, add conventional adjuvant,, process clinical acceptable tablet, granule, pill, capsule, slow releasing agent, oral liquid according to common process.
6. like the arbitrary described preparation of drug combination method of claim 1-4, comprise the steps: that above 12 flavors are ground into fine powder, sieve, mixing, the system granule, drying, encapsulated.
7. like the arbitrary described preparation of drug combination method of claim 1-4, comprise the steps: above 12 flavors, be ground into fine powder, sieve, mixing, the system granule, drying, tabletting is processed tablet.
8. like the arbitrary described preparation of drug combination method of claim 1-4, comprise the steps: above 12 flavor decoctings after, concentrate, filter, process oral liquid.
9. like the arbitrary described preparation of drug combination method of claim 1-4, comprise the steps: above 12 flavors, Rhizoma Gastrodiae, Radix Codonopsis, Carapax et Plastrum Testudinis and Radix Angelicae Sinensis powder are broken into fine powder; Sieve, be condensed into the thick paste shape after all the other 8 flavor liquid medicine boil, with the mixed granule of above-mentioned fine powder; Drying, encapsulated.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736020A (en) * | 2014-01-04 | 2014-04-23 | 王政乾 | Traditional Chinese medicine composition for treating ischemic cerebrovascular disease and preparation method thereof |
| CN105287727A (en) * | 2015-10-28 | 2016-02-03 | 郭旺水 | Traditional Chinese medicine composition for treating apoplexy and preparing method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN101658661A (en) * | 2008-08-28 | 2010-03-03 | 天津市中宝制药有限公司 | Chinese medicinal composition having effect of promoting blood circulation and removing blood stasis |
| CN101879298A (en) * | 2010-07-09 | 2010-11-10 | 王巧玲 | Chinese patient medicament for treating cardiovascular and cerebrovascular diseases |
| CN102335395A (en) * | 2011-10-12 | 2012-02-01 | 赵全成 | Health care wine for preventing hypertension and ischemic cardiovascular and cerebrovascular diseases, and preparation method thereof |
| CN102552811A (en) * | 2012-01-27 | 2012-07-11 | 王政乾 | Oral Chinese medicine composition for treating apoplexy |
-
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN101658661A (en) * | 2008-08-28 | 2010-03-03 | 天津市中宝制药有限公司 | Chinese medicinal composition having effect of promoting blood circulation and removing blood stasis |
| CN101879298A (en) * | 2010-07-09 | 2010-11-10 | 王巧玲 | Chinese patient medicament for treating cardiovascular and cerebrovascular diseases |
| CN102335395A (en) * | 2011-10-12 | 2012-02-01 | 赵全成 | Health care wine for preventing hypertension and ischemic cardiovascular and cerebrovascular diseases, and preparation method thereof |
| CN102552811A (en) * | 2012-01-27 | 2012-07-11 | 王政乾 | Oral Chinese medicine composition for treating apoplexy |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736020A (en) * | 2014-01-04 | 2014-04-23 | 王政乾 | Traditional Chinese medicine composition for treating ischemic cerebrovascular disease and preparation method thereof |
| CN105287727A (en) * | 2015-10-28 | 2016-02-03 | 郭旺水 | Traditional Chinese medicine composition for treating apoplexy and preparing method and application thereof |
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