CN102008571B - Traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition, comprising the following effective medicament components in parts by weight: 1-5 parts of epimedium herb extract, 1-5 parts of kudzu root extract, 1-5 parts of radix astragali extract, 0.5-2 parts of hawthorn leaf extract, 0.1-0.3 part of radix pseudo-ginseng extract and 0.3-0.7 part of cassia twig extract. The invention also provides a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition utilizes the epimedium herb extract, the kudzu root extract and the radix astragali extract as main components, and is additionally provided with the hawthorn leaf extract, the radix pseudo-ginseng extract and the cassia twig extract, and the effective components are mutually complemented to achieve the functions of mutual synergy and improved curative effect. The obtained traditional Chinese medicine composition has obvious curative effect and no obvious toxic or side effect. The preparation method in the invention is simple in operation, and the obtained composition has good curative effect which is obviously superior to that of the existing drug when being used for curing myocardial ischemia, and has practicability.

Description

A kind of Chinese medicine composition

Technical field

The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of medicine of treating myocardial ischemia.

Background technology

Myocardial ischemia is meant that the hemoperfusion of heart reduces, and causes the oxygen supply of heart to reduce, and energy metabolism of myocardial is undesired, can not support a kind of pathological state of heart operate as normal.Clinical demonstration causes main, the modal cause of disease of myocardial ischemia, is that coronary artery (accidental pulmonary artery) is narrow.And the main cause of coronary stricture is an atherosclerosis.The heart disease that causes because of coronary atherosclerosis is exactly the coronary heart disease that the big daily life of a family is said.So coronary heart disease is myocardial ischemia " arch-criminal ".

Myocardial ischemia all possibly bring many adverse effects to heart and whole body.Myocardial ischemia can directly cause anoxia, and energy essential when making cardiomotility is under-supply, and metabolic refuse can not be removed effectively in time, finally can influence the contractile function of heart.Myocardial ischemia also can damage diastolic function.Shrink badly, be prone to cause ventricular filling pressure to raise, cause pulmonary congestion, can cause that also complicated material metabolism disorder and myocardial electrical activity are not normal with diastole is bad combines.Therefore,, cause of disease symptomatic treatment should be found accurately, just potential serious consequence can be avoided in case myocardial ischemia occurs.The medicine of treating myocardial ischemia now has a lot, but curative effect can not be satisfactory, and takes for a long time and can produce certain toxic and side effects to human body.

Summary of the invention

The present invention is directed to above-mentioned deficiency, a kind of Chinese medicine composition is provided, this Chinese medicine composition position pure plant extracts, evident in efficacy, no obvious toxic-side effects.

The present invention also provides the method for preparing of this Chinese medicine composition.

The present invention also provides the application of this Chinese medicine composition in the treatment myocardial ischemia.

The present invention realizes through following measure:

A kind of Chinese medicine composition is characterized in that effective ingredient comprises the raw material of following weight portion:

Herba Epimedii extract 1-5 part, Radix Puerariae extract 1-5 part, Radix Astragali extract 1-5 part, Folium Crataegi extract 0.5-2 part, Radix Notoginseng extract 0.1-0.3 part, Ramulus Cinnamomi extract 0.3-0.7 part;

Said Herba Epimedii extract and Radix Puerariae extract are Herba Epimedii or the Radix Puerariae extract through ethanol extraction, macroporous resin adsorption gained; Folium Crataegi extract and Radix Astragali extract are the water extract of the Fructus Crataegi or the Radix Astragali; Radix Notoginseng extract is the ethanol extraction of Radix Notoginseng, and Ramulus Cinnamomi extract adopts the extract of steam distillation gained for the Ramulus Cinnamomi decoction pieces.

The optimization formula of above-mentioned Chinese medicine composition is (weight portion): 2 parts of Herba Epimedii extracts, 2 parts of Radix Puerariae extracts, 2 parts of Radix Astragali extracts, 1 part of Folium Crataegi extract, 0.2 part of Radix Notoginseng extract, 0.5 part of Ramulus Cinnamomi extract.

The dosage form of above-mentioned Chinese medicine composition is tablet or capsule.

The method for preparing of above-mentioned Chinese medicine composition is characterized in that may further comprise the steps:

(1) preparation of each extract

A. the preparation of Herba Epimedii extract: Herba Epimedii is added the alcohol reflux twice of 5-6 quality 50-70wt% doubly, each 2～3 hours, merge extractive liquid; Reclaim ethanol and be concentrated into an amount of; After centrifugal supernatant is used absorption with macroporous adsorbent resin, water is got express developed then, the ethanol elution of reuse 50-70wt%; Collect ethanol elution; Eluent reclaims and to carry out spray drying behind the ethanol or with the eluent thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31,60 ℃ of vacuum decompression dryings, Herba Epimedii extract;

B. the preparation of Radix Puerariae extract: with the Radix Puerariae section, the alcohol heating reflux that adds 6-7 quality 60-70wt% doubly extracts twice, each 2-3h; Merge extractive liquid, reclaims ethanol and also is concentrated in right amount, supernatant is used absorption with macroporous adsorbent resin after centrifugal; Water is got express developed then; The ethanol elution of reuse 50-70wt% is collected ethanol elution, and eluent reclaims and carries out spray drying behind the ethanol or with the eluent thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31; 60 ℃ of vacuum decompression dryings get Radix Puerariae extract;

C. the preparation of Radix Astragali extract: the Radix Astragali is added 10 quality decocting doubly boil 2 times, 1.5h filters the back and merges twice filtrating at every turn, carries out spray drying or 60 ℃ of vacuum dryings after the concentrating under reduced pressure filtrating, gets Radix Astragali extract;

D. the preparation of Folium Crataegi extract: Folium Crataegi is embathed totally with clear water and deionized water, remove rhizome after drying, get leaf and partly use 20 quality times deionized water digestion 1 h, the lyophilization of will filtrating after the filtration gets Folium Crataegi extract;

E. the preparation of Radix Notoginseng extract: Radix Notoginseng is mixed with 6-10 quality 30-60% ethanol doubly; Twice of 70 ℃ of heating and refluxing extraction; Each 40 min that extract merge extracted twice liquid, reclaim to carry out spray drying behind the ethanol or with the extracting solution thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31; 60 ℃ of drying under reduced pressure get Radix Notoginseng extract;

F. the preparation of Ramulus Cinnamomi extract: the Ramulus Cinnamomi decoction pieces is extracted volatile oil with steam distillation, the thick paste that it is 1.30-1.31 that distillate is condensed into 80 ℃ of following relative densities, spray drying or 60 ℃ of vacuum decompression dryings get Ramulus Cinnamomi extract;

(2) preparation of granule or tablet: get above-mentioned various extract in proportion; With the abundant mix homogeneously of adjuvant, cross 100 mesh sieves, the PVPP with recipe quantity 1/3 presses the abundant mix homogeneously of method that equivalent drips then; Cross 100 mesh sieves; With 95wt% ethanol system soft material, cross 24 mesh sieves, process granule or tablet forming.

The present invention also provides the application of above-mentioned Chinese medicine composition in the treatment myocardial ischemia, and this curative effect of medication is remarkable, when treatment myocardial ischemia disease, is superior to existing medicine.

The usage of Chinese medicine composition of the present invention is oral, and consumption is every day 2-3 time, each 0. 6-1.8g, and said Chinese medicine composition does not have obvious toxic-side effects, does not have obviously taboo in use.

Radix Notoginseng extract, warm in nature, sweet in the mouth, little hardship, chemical constituent are mainly ginsenoside Rb1, Rg1, Rg2 and a small amount of ginsenoside Ra, Rb2, Rb and Re for containing Saponin, in addition, still contain flavonoid glycoside, starch, protein, oils and fats etc.Have the promoting blood circulation to remove blood stasis effect, expand blood vessel, blood pressure lowering, ability antiplatelet aggregation, antithrombotic formation, resisting myocardial ischemia, anti-cerebral ischemia, arrhythmia, antiatherogenic drug action.Folium Crataegi extract, circulation of qi promoting dissipating blood stasis, ability antiplatelet aggregation, antithrombotic formation, resisting myocardial ischemia, anti-cerebral ischemia, arrhythmia, antiatherogenic drug action.Herba Epimedii extract, warming and recuperating the kidney-YANG can obviously reduce Peripheral resistance, and left chamber output is increased, and reduces cardiac load, increases peripheral organ's perfusion, and arrhythmia can also improve cerebral ischemia and cerebral anoxia, improves hypoxia-bearing capability.Radix Puerariae extract has yang invigorating expelling pathogenic factors from muscles, resisting myocardial ischemia, arrhythmia, expansion blood vessel, blood pressure lowering, improves hemorheological property and antithrombotic effect.Radix Astragali extract has during QI invigorating builds, multiple effects such as arrhythmia, resisting myocardial ischemia, blood pressure regulation, diuresis, enhancing human body immunity function.Ramulus Cinnamomi extract has antalgic, supporing yang activating QI, and blood vessel dilating is regulated sanguimotor effect.

This Chinese medicine composition is a main component with Herba Epimedii extract, Radix Puerariae extract and Radix Astragali extract; Be aided with Folium Crataegi extract, Radix Notoginseng extract and Ramulus Cinnamomi extract; Through auxilliary mutually the helping each other between each effective ingredient; Play collaborative each other, as to improve curative effect effect, the Chinese medicine composition of gained obvious toxic-side effects evident in efficacy, no.Method of the present invention is simple to operate, and the gained curative effect of medication is good, and curative effect obviously is superior to existing medicine when being used for the myocardial ischemia disease, has practicality.

The specific embodiment

Below in conjunction with specific embodiment the present invention is further set forth, should be understood that, following explanation only is in order to explain the present invention, its content not to be limited.

Embodiment 1

Herba Epimedii extract 2g, Radix Puerariae extract 2g, Radix Astragali extract 2g, Folium Crataegi extract 1g, Radix Notoginseng extract 0.2g, Ramulus Cinnamomi extract 0.5g.

Method for preparing is:

1, the preparation of each medicinal substances extract

A. the preparation of Radix Notoginseng extract: Radix Notoginseng is mixed with 6-10 quality 30-60% ethanol doubly; Twice of 70 ℃ of heating and refluxing extraction; Each 40 min that extract merge extracted twice liquid, carry out spray drying or be condensed into 80 ℃ of following relative densities the thick paste that is 1.30-1.31 behind the recovery ethanol; 60 ℃ of drying under reduced pressure get Radix Notoginseng extract;

B. the preparation of Folium Crataegi extract: Folium Crataegi is embathed totally with clear water and deionized water, remove rhizome after drying, get leaf and partly use 20 quality times deionized water digestion 1 h, the lyophilization of will filtrating after the filtration gets Folium Crataegi extract;

C. the preparation of Radix Astragali extract: the Radix Astragali is added 10 quality decocting doubly boil 2 times, 1.5h filters the back and merges twice filtrating at every turn, carries out spray drying or 60 ℃ of vacuum dryings after the concentrating under reduced pressure filtrating, gets Radix Astragali extract;

D. the preparation of Radix Puerariae extract: with the Radix Puerariae section, the alcohol heating reflux that adds 6-7 quality 60-70wt% doubly extracts twice, each 2-3h; Merge extractive liquid, reclaims ethanol and also is concentrated in right amount, supernatant is used absorption with macroporous adsorbent resin after centrifugal; Water is got express developed then; The ethanol elution of reuse 50-70wt% is collected ethanol elution, reclaims to carry out spray drying behind the ethanol or with the eluent thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31; 60 ℃ of vacuum decompression dryings get Radix Puerariae extract;

E. the preparation of Herba Epimedii extract: Herba Epimedii is added the alcohol reflux twice of 5-6 quality 50-70wt% doubly, each 2～3 hours, merge extractive liquid; Reclaim ethanol and be concentrated into an amount of; After centrifugal supernatant is used absorption with macroporous adsorbent resin, water is got express developed then, the ethanol elution of reuse 50-70wt%; Collect ethanol elution; Reclaim and to carry out spray drying behind the ethanol or the eluent thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31,60 ℃ of vacuum decompression dryings, Herba Epimedii extract;

F. the preparation of Ramulus Cinnamomi extract: the Ramulus Cinnamomi decoction pieces is extracted volatile oil with steam distillation, the thick paste that it is 1.30-1.31 that distillate is condensed into 80 ℃ of following relative densities, spray drying or 60 ℃ of vacuum decompression dryings get Ramulus Cinnamomi extract;

2, the preparation of preparation: get above-mentioned various extract in proportion,, cross 100 mesh sieves with the abundant mix homogeneously of adjuvant; PVPP with recipe quantity 1/3 presses the abundant mix homogeneously of method that equivalent drips then, crosses 100 mesh sieves, with 95wt% ethanol system soft material; Cross 24 mesh sieves, tablet forming.

Embodiment 2

Herba Epimedii extract 1g, Radix Puerariae extract 3g, Radix Astragali extract 5g, Folium Crataegi extract 1g, Radix Notoginseng extract 0.1g, Ramulus Cinnamomi extract 0.4g.

Method for preparing is with embodiment 1.

Embodiment 3

Herba Epimedii extract 5g, Radix Puerariae extract 1g, Radix Astragali extract 1g, Folium Crataegi extract 2g, Radix Notoginseng extract 0.3g, Ramulus Cinnamomi extract 0.7g.

Method for preparing is with embodiment 1.

Embodiment 4

Herba Epimedii extract 3g, Radix Puerariae extract 5g, Radix Astragali extract 3g, Folium Crataegi extract 0.5g, Radix Notoginseng extract 0.2g, Ramulus Cinnamomi extract 0.3g.

Method for preparing is with embodiment 1, and different is to process granule.

Carry out following zoopery in the face of medicine of the present invention down

1, to the influence of hybrid dog myocardial infarction and ischemia model

1.1 experiment medicine

Experimental group is the medicine of the embodiment of the invention 1, and matched group is an XUESAITONG PIAN, and XUESAITONG PIAN is mainly the effective site Radix Notoginseng total arasaponins that the araliaceae ginseng plant Radix Notoginseng is extracted.

1.2 drug dose

The experimental group drug dose is respectively 200 mg/kg, 100 mg/kg, 50 mg/kg; The matched group consumption is 40 mg/kg.

1.3 experimental technique

Get 30 of hybrid dogs, be divided into 5 groups at random, with 30mg/kg pentobarbital sodium iv anesthesia, back of the body position is fixing; Skin of neck cuts, and tracheal intubation connects SC23 type artificial respirator, and the 4th intercostal is executed thoracotomy in the left side; Expose heart, cut off pericardium, separate 1/3 place under the LADCA, ligation behind the threading; The preparation myocardial infarction model adopts multiple spot cloth formula absorption method mark to survey multi-lead electrocardiogram (EECG), 24 of mark measuring points, a sham operated rats not ligation of threading.Near infarct, select 12 mark measuring points; And selecting 1 control point away from infarct, hand-held insulated metal point-like electrode is marked survey in proper order by the mark measuring point, through pick off JB-642G, amplifier AB-621G; Lead physiograph record EECG EECG, calibration: 1mm=1mv with eight.After 15min and the administration 5,15,30,60,90 and the EECG of 120min, add up each punctuate ST field offset summation ∑-ST after the record ligation, and the ST section is raised >=number N-ST more than the 2mv.Each group is got blood respectively at 60min femoral vein after 15min and the administration before the ligation, after the ligation, with kit measurement serum CK, LDH value.Experiment is taken out heart, with normal saline flush away blood after finishing immediately; Take by weighing heavy whole-heartedly heavy with ventricle; And become the U sheet to the ventricle crosscut, and place 37 ℃ of 1%TTC solution 10min that dyes, cut off the non-infarct that each myocardium sheet is colored; Weigh undyed infarct cardiac muscle, obtain infarction size heavily respectively divided by ventricle and account for the heavy percentage rate of ventricle.Experimental data is all represented with X ± S, relatively adopts the t check between group.

1.4 experimental result

Experiment confirm, the medicine of 3 dosage of the present invention to cardiac muscle stalk due to the anesthetized dog coronary ligation protective effect all be better than XUESAITONG, explain that the present invention and XUESAITONG compare myocardial infarction and have the significant protection effect.

2. to the influence of rat heart muscle ischemia model

2.1 experiment medicine

Experimental group is a medicine of the present invention, and matched group is a FUFANG DANSHEN PIAN, and the FUFANG DANSHEN PIAN ingredient is mainly Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum.

2.2 drug dose

The experimental group drug dose is respectively 200 mg/kg, 100 mg/kg, 50 mg/kg; The matched group consumption is 100 mg/kg.

2.3 experimental technique:

60 of wistar rats are divided into 6 groups at random: model group, sham operated rats, 200mg/kg, 100 mg/kg, 50mg/kg dosage experiments group, matched group.Model group, sham operated rats are irritated stomach and are given distilled water 10ml/kg, and all the other each groups are irritated stomach and given relative medicine.Once a day, successive administration 7d, 60min behind the last medicine; With 20% urethane intraperitoneal anesthesia rat (0.5ml/100g); At the about 2cm of left mid-clavicular line longitudinal incision skin, open the thoracic cavity at the 4th and the 5th intercostal, cut off pericardium; (only not ligation of threading of sham operated rats) closed the thoracic cavity rapidly behind ligation left coronary artery between arterial cone and the left auricle.Reach postoperative 120 min before the art and write down rat front electrocardiogram (ECG) respectively, measure the S-T section and change.Postoperative 2 h win rat heart, and NS washes residual to the greatest extent blood with ice; Blot with filter paper, weigh, 0.1 g is freezing rapidly for the point tissue of coring; Left ventricle is cut into the thick thin slice of 1-2 mm; With 0.1% chlorination nitro blue tetrazolium (NBT) dyeing 15mi (37 ℃ ± 0.5 ℃), cut the myocardial infarction district that is not colored after the taking-up, blot with filter paper; Weigh, calculate infarcted myocardium and account for heavy whole-heartedly percentage rate.Prepare myocardium homogenate with 0.9% normal saline, measure active, malonaldehyde (MDA) content of creatine phosphokinase (CPK), superoxide dismutase (SOD) in the myocardium homogenate.All data are carried out statistical procedures with SPSS11.0 software, all represent t check between relatively employing group of each item index with x ± s form.

2.4 experimental result

1. to the influence of rats with myocardial ischemia electrocardiogram S-T section and myocardial infarction area: model group electrocardiogram S-T section is significantly raised; Infarct size is 24.76%; Relatively has significant difference (P < 0.01) with sham operated rats; The ECG S-T section of 100mg/>kg, 200mg/kg dosage experiments group and FUFANG DANSHEN PIAN group significantly reduces, infarct size reduces, with model group relatively have significant difference (P 0.05 or P 0.01), experimental group low dose group S-T section and model group comparison there was no significant difference.The result sees table 4 and table 5.

2. experimental group is to the influence of ischemic myocardium SOD, MDA: model group rat heart muscle SOD is active significantly to be reduced, and MDA content significantly increases, and relatively has significant difference with sham operated rats.50mg/kg, 100mg/kg, 200mg/kg dosage experiments group group and FUFANG DANSHEN PIAN group, SOD is active to be increased, MDA content reduces, with model group relatively have significant difference (P 0.05 or P 0.01).Experimental group is superior to the FUFANG DANSHEN PIAN group, and the result sees table 6.

3. experimental group to ischemic myocardium CPK influence that model group rat heart muscle CPK is active significantly to be reduced, relatively have significant difference (P < 0.01) with sham operated rats.50mg/>kg, 100mg/kg, 200mg/kg dosage experiments group and FUFANG DANSHEN PIAN group, CPK is active to be increased, with model group relatively have significant difference (P 0.05 or P 0.01).Experimental group is superior to FUFANG DANSHEN PIAN, and the result sees table 7.

3, conclusion: above data declaration the drug action of treatment myocardial ischemia of medicine of the present invention obviously be superior to FUFANG DANSHEN PIAN.

Clinical trial

1, case source

The patient that random choose 150 examples have the myocardial ischemia disease in this city hospital wherein, is equally divided into 5 groups, and the 1-4 group adopts the medicine of embodiment 1-4 respectively, and the 5th group is adopted XUESAITONG as control drug.Wherein, the 1st group of male's 15 examples, women's 15 examples, 18～60 years old age, the course of disease 1～10 year; The 2nd group of male's 13 examples, women's 17 examples, 18～60 years old age, course of disease 1-10; The 3rd group of male's 11 examples, women's 19 examples, age 18-60 year, course of disease 1-10; The 4th group of male's 17 examples, women's 13 examples, 18～63 years old age, course of disease 1-10; The 5th group of male's 18 examples, women's 12 examples, age 18-60 year, course of disease 1-10.

2, Therapeutic Method

The 1-4 group makes medicament 0.6g at every turn, and every day 3 times, the 5th group makes medicament 0.1g at every turn, every day 3 times.Each group was taken medicine 30 days.

3, curative effect is judged

Produce effects: angina pectoris obviously improves, and does not have angina pectoris basically or number of times obviously reduces, and electrocardiogram obviously improves or recovers normal;

Effectively: angina pectoris improves, and no angina pectoris number of times reduces, and electrocardiogram improves;

Invalid: angina pectoris does not have improvement basically, and electrocardiogram does not have obvious improvement.

4, therapeutic outcome

Model case:

Mr. Zhang, 40 years old, suffered from coronary heart disease 10 years, take the medicine 10 days of the embodiment of the invention 1; Electrocardiogram obviously improves, and takes medicine 20 days, and the nitroglycerin number of applications drops to 0-1 time by 4-5 time weekly; After taking medicine 40 days, it is normal that electrocardiogram recovers, the nitroglycerin of stopping using basically, and angina pectoris is by 3-4 time weekly; Reduce to 0-1 time, took medicine 5 years, do not see untoward reaction.

Mrs Li 58 years old, suffered from coronary heart disease 6 years, the medicine of the embodiment of the invention of taking medicine 3 15 days; Electrocardiogram obviously improves, and takes medicine 30 days, and the nitroglycerin number of applications drops to 0-1 time by 3-4 time weekly; After taking medicine 60 days, it is normal that electrocardiogram recovers, the nitroglycerin of stopping using basically, and angina pectoris is by 3-4 time weekly; Reduce to 0-1 time, took medicine 3 years, do not see untoward reaction.

Mrs Wang, 55 years old, suffered from coronary heart disease 5 years, take the medicine 15 days of the embodiment of the invention 4; Electrocardiogram obviously improves, and takes medicine 30 days, and the nitroglycerin number of applications drops to 0-1 time by 2-3 time weekly; After taking medicine 40 days, it is normal that electrocardiogram recovers, the nitroglycerin of stopping using basically, and angina pectoris is by 2-3 time weekly; Reduce to 0-1 time, took medicine 3 years, do not see untoward reaction.

Mr. Xie, 38 years old, suffered from coronary heart disease 2 years, take the medicine 10 days of the embodiment of the invention 2; Electrocardiogram obviously improves, and takes medicine 20 days, and the nitroglycerin number of applications drops to 0-1 time by 2-3 time weekly; After taking medicine 30 days, it is normal that electrocardiogram recovers, the nitroglycerin of stopping using basically, and angina pectoris is by 2-3 time weekly; Reduce to 0-1 time, took medicine 3 years, do not see untoward reaction.

Claims (5)

1. Chinese medicine composition of treating myocardial ischemia is characterized in that effective ingredient is made up of the raw material of following weight portion:

Herba Epimedii extract 1-5 part, Radix Puerariae extract 1-5 part, Radix Astragali extract 1-5 part, Folium Crataegi extract 0.5-2 part, Radix Notoginseng extract 0.1-0.3 part, Ramulus Cinnamomi extract 0.3-0.7 part;

Said Herba Epimedii extract and Radix Puerariae extract are Herba Epimedii or the Radix Puerariae extract through ethanol extraction, macroporous resin adsorption gained; Folium Crataegi extract and Radix Astragali extract are the water extract of the Folium Crataegi or the Radix Astragali; Radix Notoginseng extract is the ethanol extraction of Radix Notoginseng, and Ramulus Cinnamomi extract adopts the extract of steam distillation gained for the Ramulus Cinnamomi decoction pieces.

2. Chinese medicine composition according to claim 1 is characterized in that effective ingredient is made up of the raw material of following weight portion: 2 parts of Herba Epimedii extracts, 2 parts of Radix Puerariae extracts; 2 parts of Radix Astragali extracts; 1 part of Folium Crataegi extract, 0.2 part of Radix Notoginseng extract, 0.5 part of Ramulus Cinnamomi extract.

3. Chinese medicine composition according to claim 1 and 2 is characterized in that: said Chinese medicine composition dosage form is tablet or capsule.

4. the method for preparing of the Chinese medicine composition of the described treatment myocardial ischemia of claim 1 is characterized in that may further comprise the steps:

(1) preparation of each extract

A. the preparation of Herba Epimedii extract: Herba Epimedii is added the alcohol reflux twice of 5-6 quality 50-70wt% doubly, each 2～3 hours, merge extractive liquid; Reclaiming second. alcohol also is concentrated into an amount of; After centrifugal supernatant is used absorption with macroporous adsorbent resin, water is got express developed then, the ethanol elution of reuse 50-70wt%; Collect ethanol elution; Eluent reclaims and to carry out spray drying behind the ethanol or with the eluent thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31,60 ℃ of vacuum decompression dryings, Herba Epimedii extract;

B. the preparation of Radix Puerariae extract: with the Radix Puerariae section, the alcohol heating reflux that adds 6-7 quality 60-70wt% doubly extracts twice, each 2-3h; Merge extractive liquid, reclaims ethanol and also is concentrated in right amount, supernatant is used absorption with macroporous adsorbent resin after centrifugal; Water is got express developed then; The ethanol elution of reuse 50-70wt% is collected ethanol elution, and eluent reclaims and carries out spray drying behind the ethanol or with the eluent thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31; 60 ℃ of vacuum decompression dryings get Radix Puerariae extract;

C. the preparation of Radix Astragali extract: the Radix Astragali is added 10 quality decocting doubly boil 2 times, 1.5h filters the back and merges twice filtrating at every turn, carries out spray drying or 60 ℃ of vacuum dryings after the concentrating under reduced pressure filtrating, gets Radix Astragali extract;

D. the preparation of Folium Crataegi extract: Folium Crataegi is embathed totally with clear water and deionized water, remove rhizome after drying, get leaf and partly use 20 quality times deionized water digestion 1 h, the lyophilization of will filtrating after the filtration gets Folium Crataegi extract;

E. the preparation of Radix Notoginseng extract: Radix Notoginseng is mixed with 6-10 quality 30-60% ethanol doubly; Twice of 70 ℃ of heating and refluxing extraction; Each 40 min that extract merge extracted twice liquid, reclaim to carry out spray drying behind the ethanol or with the extracting solution thick paste that to be condensed into 80 ℃ of following relative densities be 1.30-1.31; 60 ℃ of drying under reduced pressure get Radix Notoginseng extract;

F. the preparation of Ramulus Cinnamomi extract: the Ramulus Cinnamomi decoction pieces is extracted volatile oil with steam distillation, the thick paste that it is 1.30-1.31 that distillate is condensed into 80 ℃ of following relative densities, spray drying or 60 ℃ of vacuum decompression dryings get Ramulus Cinnamomi extract;

(2) preparation of granule or tablet: get above-mentioned various extract in proportion; With the abundant mix homogeneously of adjuvant, cross 100 mesh sieves, the PVPP with recipe quantity 1/3 presses the abundant mix homogeneously of method that equivalent drips then; Cross 100 mesh sieves; With 95wt% ethanol system soft material, cross 24 mesh sieves, process granule or tablet forming.

5. the application of the Chinese medicine composition of the described treatment myocardial ischemia of claim 1 in the medicine of preparation treatment myocardial ischemia.