CN1437959A - Chinese prepartory for treating cardiovascular and cerebrovascular disease and preparation method - Google Patents
Chinese prepartory for treating cardiovascular and cerebrovascular disease and preparation method Download PDFInfo
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Abstract
The composition of Chinese patent medicine for curing cardio-cerebral vascular diseases comprises (wt%) 82-87% of bran and coarse grain, 13-18% of plant medicinal material for curing cerebrovascular disease and microscale of saccharifying enzyme and lactobacillin, which is characterized by that the composition of said plant medicinal material comprises (wt%) 28-37% of main medicinal material, 23-30% of secondary medicinal materials, 27-41% of auxiliary medicinal material and 5-7% of flavouring material, and its preparation method includes the following steps: selecting materials, pulverizing, mixing, steaming, cooling, inoculating, showering, sterilizing, filtering, inspection, packaging and putting in storage.
Description
Background technology:
At present, cardiovascular and cerebrovascular disease, coronary heart disease, hypertension have become the healthy major hidden danger of harm people, even the serious life that jeopardizes the mankind, the reason of searching to the bottom, and it is relevant with the just present mutually interdependent living environment of people; Relevant with the living habit that people are bad; Also with people up to the present, grinding of human life's science made internal disorder or usurp also not reach grasp relevantly completely, real be used for the treatment of the medicine of cerebrovascular disease from the human life science, comprise Chinese medicine and western medicine, its pharmaceutical compositions is more single.But the good news is: the science of must finishing is in development, human probe into and learns making great efforts untiringly, the new science of human life's science ground make internal disorder or usurp in development, and new medical medicine also constantly is developed.
By one of the applicant comrade Yang Zhidong application number be: 01127334.8; Name is called a kind of method for preparing Dietotherapy health vinegar and the application for a patent for invention of the Dietotherapy health vinegar produced with this method, and it discloses a kind of component composition that is used for making vinegar: the thick miscellaneous grain crops of furfur, plant amedica, saccharifying enzyme and acetic acid bacteria strain; In human body, played the effect of prevention, health care simultaneously, but should invent mainly from the necessary for human nutritional need, the angle of anti-pre-multiple disease is considered, be medicine-food two-purpose, nutritional labeling is in the majority, and types of drugs is few, and pharmaceutical compositions content is little, contain medical material quantity not sufficient 4g in one kilogram of vinegar, compare insignificant with one pair of Chinese medicine of going up hectogram; Can not reach the real effect of curing the disease:
Summary of the invention:
For solving the deficiency of the Chinese patent medicine problem existence that is exclusively used in the treatment cerebrovascular disease as mentioned above, the purpose of this invention is to provide a kind of Chinese patent medicine for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, codes have suffered whole nutritional factorss of needed by human, more paid attention to the medicine composition, thereby broken the traditional thought of a few flavor Chinese prescriptions, medicine and nutritional factors are organically combined, real from human life science's angle, solve the treatment problem of human cardiovascular and cerebrovascular disease.
For achieving the above object, the present invention adopts following technical scheme:
The Chinese patent medicine of described treatment cardiovascular and cerebrovascular disease, it contains the thick miscellaneous grain crops of furfur, edible plants medical material, saccharifying enzyme and acetic acid bacteria strain trace.Wherein the thick miscellaneous grain crops 82-87% of furfur treats the plant amedica 13-18% of cerebrovascular aspect, and in the prescription of vegetable drug, its principal agent is 28-37%, and inferior medicine is 23-30%, and adjuvant is 27-41%, condiment 5-7%.
The Chinese patent medicine of described treatment cardiovascular and cerebrovascular disease, its principal agent is: Folium Ginkgo, Rhizoma Dioscoreae, Fructus Crataegi, Fructus Lycii, Radix Puerariae; Inferior medicine is: Rhizoma Polygonati, the Cortex Eucommiae, the Radix Polygoni Multiflori, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Cortex Cinnamomi, Flos Chrysanthemi, Semen Cassiae, Fructus Mori, Spica Prunellae, Radix Glycyrrhizae, Fructus Corni, Aloe etc.; Adjuvant is: Ramulus Cinnamomi, Folium Perillae, Folium Mori, the Radix Angelicae Dahuricae, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, Radix Scrophulariae, Cortex Lycii, Fructus Forsythiae, Semen Sterculiae Lychnophorae, Cortex Mori, Radix agastaches, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Fructus Cannabis, Flos Caryophylli, an ancient unit of weight rattan, Rhizoma Gastrodiae, Pheretima, Fructus Tribuli, Semen Ziziphi Spinosae, Poria, Rhizoma Alismatis, Semen Plantaginis, Semen Coicis, Radix Stephaniae Tetrandrae, Herba Taxilli, Herba Siegesbeckiae, Radix Ginseng, Flos Sophorae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Herba Leonuri, Flos Carthami, Rhizoma Curcumae Longae, Radix Codonopsis, the Radix Astragali, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Herba Epimedii, Semen Cuscutae, Radix Ephedrae, Semen Euryales, Cortex Moutan, Semen Raphani; Condiment medicine: Fructus Piperis, Pericarpium Zanthoxyli, anise, Rhizoma Zingiberis Recens, Fructus Foeniculi, Fructus Foeniculi, Bulbus Allii, Herba Pelargonii Graveolentis.
The Chinese patent medicine of described treatment cardiovascular and cerebrovascular disease, it can make liquid formulation, need only add 1% sodium benzoate antiseptic, in order to improve mouthfeel, adds 1% natural spissated Folium Stevlae Rebaudianae again.
The Chinese patent medicine of described treatment cardiovascular and cerebrovascular disease, it also can be made into solid-state pill: it does not add rice husk with the powder of 10 microns of grain and pulverizing medicinal materials when steaming material, treat the material fermentation after, get the material airing, admix 10% Mel and arabic gum, make pill.
The process of the Chinese patent medicine of described making treatment cardiovascular and cerebrovascular disease, at first in the ratio of the plant amedica 13-18% of treatment cerebrovascular aspect in the medicine, wherein principal agent is 28-37%, and inferior medicine is 23-30%, and adjuvant is 27-41%, condiment 5-7%; Ratio according to the thick miscellaneous grain crops 82-87% of furfur; Add saccharifying enzyme and acetic acid bacteria strain trace, its component group amount is required to weigh; Selected medical material-guiding drug-pulverizing-mixing-steam heated-cooling-adding strain fermentation-essence pouring-sterilization-filtration-check-packing-warehouse-in,
The process of the Chinese patent medicine of described making treatment cardiovascular and cerebrovascular disease, grain and medical material after pulverizing are machined to 10 microns micropowders with superfine grinding, add rice husk mix homogeneously again with above-mentioned material equivalent, pack in the steam kettle, use the steamed material, waited to expect well-done about 1 hour, and stopped heating, will expect that taking-up is layered on the clean water mire and is cooled to 30 ℃.Add strain: the dry yeast and the acetic acid bacteria strain of adding 2%, mix homogeneously, dress cylinder.Stirring: the ceramic cylinder of splendid attire material, about 100 liters, loam cake after the material compacting is advisable at a mouthful big end for a short time.Left and right sides material heating in five days, after temperature rises to 40 ℃ (using thermometer measure), the beginning stirring.The stirring method is that material is shoveled in another empty cylinder of getting ready with spade, and this stage is the alcohol fermentation phase, in order to prolong the alcohol fermentation phase, avoid air admission as far as possible, material compresses in right amount, and material can not compacting after 10 days, allows air admission, ethanol changes into acetic acid, behind the acetic fermentation 5 days, measure its acidity every day, reach 3.5 degree by this prescription acidity, no longer raise, stop fermentation.
The present invention has following superiority:
Why the present invention has excellent curative, and its reason is: have in the prescription that Rhizoma Polygonati, Radix Angelicae Sinensis, the Cortex Eucommiae, silver contain, kind of a rare Chinese medicine surplus the Fructus Corni etc. 60.Its composition and effectiveness are very extensive.Can be divided into eight big classes such as terpenoid, peptide and amino acids, flavonoid, polysaccharide, sulfide linkage compounds, unsaturated fatty acids, biological alkali class and sterols by its composition.Their organic principle is very active, and static electrification or positive and negative charge have extremely strong free radical resisting ability, and the infringement of treatment radical pair cerebral blood vessel and hypertension, coronary heart disease are had remarkable efficacy; The energy blood circulation promoting and blood stasis dispelling, improve blood vessel elasticity, strengthen cerebrum blood circulation and oxygen carrying capacity, increase crown moving blood flow, improve blood supply in brain deficiency and blood quality, blood fat reducing and blood viscosity, reduce and improve lipid materials such as cholesterol, triglyceride, treatment platelet aggregation (blood clotting) is prevented and treated thrombosis, and has enhancing immunity and defying age, effect of prolonging life.
1, also containing multiple trace meter in the medical material does not have element, and their characteristics are that content is few, active high, and it is fast to be absorbed by the body.Contain Zn, Mn, Cu, Mg etc. as Rhizoma Polygonati; Fructus Schisandrae Chinensis contains K, Ca, Zn, Mn, Fe, Si, P etc.; The content of Cr is more high in the Fructus Corni, they all have different useful effects to human body, are the main trace element of bringing back to life thymus as Zn, and thymus is immune commander in chief, Zn is that present known participation enzyme generates maximum trace element, and enzyme is cell tissue and metabolic essential material.Minor metallic element is the requisite material of human body in a word.Can be divided into by its medicinal effectiveness: dredge the meridian passage, blood circulation promoting and blood stasis dispelling, detoxifcation relieve the pain, calmness, tonification, atmosphere of news service dehumidifying, removing heat-phlegm, spleen invigorating help the different effectiveness of kind surplus stomach etc. 30.
2, guiding drug: kind of mixed grain rice are formed surplus five meters, Semen setariae, Testa Tritici, bran coat etc. ten, and its nutritional labeling is very abundant.Corn contains the vegetalitas egg from senior nutritional factorss such as matter, fat, saccharide, vitamin, mineral, Ca, P, Fe, Mg and linoleic acid, carotene, VE and glutathion except that starch.Glutathion is the organic compound of a kind of Se of containing, be described as longevity factor, its antioxidation is higher 500 times than the VE that is called as antidotal agent, and the contained VE of Semen Maydis oil has tangible cholesterol reducing and prevents and treats cerebral arteriosclerosis, coronary heart disease, hypertensive effect.The growth of the lysine energy anticancer in the corn, corn cob, Stigma Maydis all have significant curative effect to diseases such as cholecystitis, cholelithiasis, yellow cellulitis hepatitis, diabetes.Bran, bran contain a large amount of water-soluble vitamin B complexes: as B1, B2, B6, folic acid, nicotinic acid, pantothenic acid, VP, biotin, to the nutritional factors of amino this formic acid, choline, inositol and needed by human such as several amino acids, mineral and cellulose, the treatment disease is played considerable assosting effect.
3, medicine matchmaker: can give full play to and transfer organic and inorganic constituents in medical material, the guiding drug, it is very complicated to form a series of structures, but Human Physiology is played the chelating body, enzyme, hormone etc. of positive role.And the effective ingredient in the medical material, guiding drug fully played and transferred under medicine matchmaker's effect, thereby reaches the ideal effect of curing the disease.This just this heart and brain medicine be different from the compatibility of other drug formulation and the unique distinction of formulation method.In specific words, the medicine matchmaker is exactly ethanol and acetic acid, and it is that guiding drug is converted into ethanol (CH with the part composition in the microorganism souring process
3COH), so oxidation generate acetic acid (CH
3COOH).Ethanol and acetic acid are the simplest, the most active (removing formic acid, methanol), press close to the human lives most, liked by people, to being useful life food on the Human Physiology, according to incompletely statistics, kind surplus only acetic acid compound just has 410 adds that acetic acid derivative reaches more than thousand kinds.The activity of acetic acid and ethanol is extremely strong, can make organic substance ever-changing.The mutual conversion of ethanol and acetic acid and organic substance is reassembled into new material, develops towards the direction that helps health and treatment disease.This just this cerebrovascular medicine composition select ethanol and acetic acid reason for use as the medicine matchmaker.
Embodiment:
The present invention treats the Chinese patent medicine of cerebrovascular disease, is calculated as example to make 1000 jin: weigh according to following component group amount, and press following technological operation:
1, grain: 170 jin (wherein Semen Maydis flour is 119 jin for corn; 51 jin of skin of Semen Maydis), 80 jin (wherein Semen setariae powder is 56 jin for Semen setariae; 24 jin of Testa oryzae), 10 jin (wherein flour is 7 jin for Semen Tritici aestivi; 3 jin in Testa Tritici), 8 jin of sweet potato powder, 5 jin of Fagopyrum esculentum Moenchs, 5 jin in Fructus Hordei Germinatus, 3 jin of Semen Sesami Nigrums, 3 jin of Semen Phaseolis, 3 jin in Semen phaseoli radiati.
2, furfur: 110 jin of skin of Semen Maydis, 48 jin of Testa oryzae; , 20 jin of Testa Triticis, 22 jin of rice chaffs.
3, principal agent is 20 jin; 15 jin of inferior medicines; Adjuvant: 235 jin.
4, condiment: 4 jin.
1, the buying of material: purchase the raw material of different growing environments and different regions, guarantee that grain is not subjected to environmental pollution, fully absorb the mixed grain rice and the vegetable drug of quintessence of elite, the earth of life.
2, screening, pulverizing; Grain directly was crushed to after screening 425, and medical material carries out fragmentation earlier, and fine powder was broken to 425 again.
3, batch mixing: grain after will pulverizing and medical material are processed into 10 microns micropowders with superfine grinding, add the rice husk mix homogeneously with above-mentioned material equivalent again, in the steam kettle of packing into, use the steamed material, waited to expect well-done about 1 hour, and stopped heating, will expect that taking-up is layered on the clean water mire and is cooled to 30 ℃.
4, add strain: the dry yeast and the acetic acid bacteria strain of adding 2%, mix homogeneously, dress cylinder.
5, stirring: the ceramic cylinder of splendid attire material, about 6100 liters, loam cake after the material compacting is advisable at a mouthful big end for a short time.Left and right sides material heating in five days, after temperature rises to 40 ℃ (using thermometer measure), the beginning stirring.The stirring method is that material is shoveled in another empty cylinder of getting ready with spade, and this stage is the alcohol fermentation phase, in order to prolong the alcohol fermentation phase, avoid air admission as far as possible, material can not compacting after material compressed 10 days in right amount, allowed air admission, and ethanol changes into acetic acid, behind the acetic fermentation 5 days, measure its acidity every day, according to this batching, temperature no longer raises after reaching 3.5 degree, i.e. fermentation stops, and gets material and drenches.
6, drench: drench material container with 500 liters big mouth ceramic cylinder, the hole that bottom one side is opened a 5CM, interlayer on cylinder bottom 10CM place frame, spread crocus cloth, prevent that material from flowing out, the material of fermentation is put in the cylinder of getting ready, be soaked in water 10 hours, the cylinder bottom hole blocks with stopper, opens the cylinder bottom hole after 10 hours, in the container that allows liquid flow out to get ready.
7, sterilization: effusive liquid still has enzyme bacterium and other antibacterials that do not have reaction, and liquid is moved in the rustless steel container, and little fire is heated to 90 ℃, 30 minutes.
8, detect: get cooling liquid and measure acidity, be finished product.Model case: (case is very many, and this only lifts two examples)
Qiao Yuxing: the man, 68 years old, the retired cadre lived family members institute of Henan Province transportation department, suffered from cerebrovascular and caused that hemiplegia for many years, is unable to leave the bed, and hundred doctors are invalid, and old father is sick to cost tens thousand of units to children in order to cure, and does not feel any better.Son Qiao Yiluo (the hostel chief of Henan Province transportation department) listens friend to say that this Chinese patent medicine can control hemiplegia, and after discussing with the father, decision takes this medicine, and JIUYUE began to take on the 9th in 2000, gets final product out-of-bed activity after 20 jin, but lifts the lower limb difficulty, and walking needs the people to assist in.After taking 30 jin, can lift both legs by height, oneself is walked, the basic rehabilitation of health.For consolidating curative effect, serve on 30 jin again, Qiao takes 60 jin always altogether, and health returns to one's perfect health.The taking out 5,000 yuans and urge son Qiao Yiluo special trip from Zhengzhou to Luoyang, to thank of his happiness.
Zhang Xiuzhen, the woman, 74 years old, Lian Zhuan township, Yiyang County Shang Jian people from village, trouble hypertension, cerebral artery vessel sclerosis cause lower limb and eyelid edema, and be drowsiness, face flushing 7 years, because of its daughter family (daughter Xin Dian and Lao Zhang live in a building), learn this message after, take this medicine on April 29th, 1999, after seven days, above-mentioned various disease alleviates, and body weight also alleviates three jin, serve on 12 jin, physical rehabilitation after one month, ask Lao Zhang " what refreshing medicine that you do has been cured my chronic illness, now can cultivate peanut down " after sick good.
Zhang Songshan: the man, 57 years old, the chief engineer of Yiyang County building constructor spring in 1993 began to suffer from hypertension, frequent dizzy, drowsiness, eyelid edema, the face flushing, spasm of the calf, build is got fat.Through diagnosis is that cerebral artery vessel hardens institute extremely.The control of taking medicine at ordinary times, annual defeated liquid, all day is on tenterhooks, fears that the state of an illness increases the weight of.
On January 31st, 1999 rose and takes this medicine, inactive simultaneously other medicines, took 20 jin in continuous 40 days, blood pressure by 100 160mmHg drop to 80 116mmHg, dizzy, drowsiness, eyelid edema, the face flushing, symptoms such as spasm of the calf all disappear, and body weight drops to 165 jin by 182 jin, alleviate 17 jin, physical rehabilitation, not recurrence so far.
Claims (6)
1, a kind of Chinese patent medicine for the treatment of cardiovascular and cerebrovascular disease, it contains the thick miscellaneous grain crops of furfur, edible plants medicine, saccharifying enzyme and acetic acid bacteria strain trace.It is characterized in that: the thick miscellaneous grain crops 82-87% of furfur wherein; The plant amedica 13-18% of treatment cerebrovascular aspect, in the prescription of vegetable drug, its principal agent is 28-37%, and inferior medicine is 23-30%, and adjuvant is 27-41%, condiment 57%.
2, the Chinese patent medicine of treatment cardiovascular and cerebrovascular disease as claimed in claim 1 is characterized in that: principal agent is in its plant amedica: Folium Ginkgo, Rhizoma Dioscoreae, Fructus Crataegi, Fructus Lycii, Radix Puerariae; Inferior medicine is: Rhizoma Polygonati, the Cortex Eucommiae, the Radix Polygoni Multiflori, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Cortex Cinnamomi, Flos Chrysanthemi, Semen Cassiae, Fructus Mori, Spica Prunellae, Radix Glycyrrhizae, Fructus Corni, Aloe; Adjuvant is: Ramulus Cinnamomi, Folium Perillae, Folium Mori, the Radix Angelicae Dahuricae, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, Radix Scrophulariae, Cortex Lycii, Fructus Forsythiae, Semen Sterculiae Lychnophorae, Cortex Mori, Radix agastaches, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Fructus Cannabis, Flos Caryophylli, an ancient unit of weight rattan, Rhizoma Gastrodiae, Pheretima, Fructus Tribuli, Semen Ziziphi Spinosae, Poria, Rhizoma Alismatis, Semen Plantaginis, Semen Coicis, Radix Stephaniae Tetrandrae, Herba Taxilli, Herba Siegesbeckiae, Radix Ginseng, Flos Sophorae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Herba Leonuri, Flos Carthami, Rhizoma Curcumae Longae, Radix Codonopsis, the Radix Astragali, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Herba Epimedii, Semen Cuscutae, Radix Ephedrae, Semen Euryales, Cortex Moutan, Semen Raphani; Condiment medicine: Fructus Piperis, Pericarpium Zanthoxyli, anise, Rhizoma Zingiberis Recens, Fructus Foeniculi, Fructus Foeniculi, Bulbus Allii, Herba Pelargonii Graveolentis.
3, the Chinese patent medicine of treatment cardiovascular and cerebrovascular disease as claimed in claim 1 is characterized in that: it can make liquid formulation, must add 1% sodium benzoate antiseptic, in order to improve mouthfeel, adds 1% natural spissated Folium Stevlae Rebaudianae again.
4, the Chinese patent medicine of treatment cardiovascular and cerebrovascular disease as claimed in claim 1, it is characterized in that: the Chinese patent medicine of described treatment cardiovascular and cerebrovascular disease, it also can be made into solid-state pill: its with grain and must pulverizing medicinal materials 10 microns powder, do not add rice husk when steaming material, after treating the material fermentation, get the material airing, admix 10% Mel and arabic gum, be made as pill.
5, a kind of manufacturing technique method of implementing as the Chinese patent medicine of claim 1 treatment cardiovascular and cerebrovascular disease, it is characterized in that: at first in the ratio for the treatment of the plant amedica 13-18% of cerebrovascular aspect in the medicine, wherein principal agent is 28-37%, inferior medicine is 23-30%, adjuvant is 27-41%, condiment 5-7%; Ratio according to the thick miscellaneous grain crops 82-87% of furfur; Add saccharifying enzyme and acetic acid bacteria strain trace, its component group amount is weighed on request, selected medical material-guiding drug-pulverizing-mixing-steam heated-cooling-adding strain fermentation-essence pouring-sterilization-filtration-check-packing-warehouse-in,
6, the process of the Chinese patent medicine of making treatment cardiovascular and cerebrovascular disease as claimed in claim 5, it is characterized in that: grain after will pulverizing and medical material ultrafine crusher, be processed into 10 microns micropowders, the rice husk mix homogeneously of adding and above-mentioned material equivalent in the steam kettle of packing into, is used the steamed material again, waited to expect well-done about 1 hour, stop heating, will expect that taking-up is layered on the clean water mire, is cooled to 30 ℃.Add strain: the dry yeast and the acetic acid bacteria strain of adding 2%, mix homogeneously, upper cylinder half, stirring, the ceramic cylinder of splendid attire material, about 100 liters, loam cake after the material compacting is advisable at a mouthful big end for a short time.Left and right sides material heating in five days, after temperature rises to 40 ℃ (using thermometer measure), the beginning stirring.The stirring method: be that material is shoveled in another empty cylinder of getting ready with spade, this stage is the alcohol fermentation phase, in order to prolong the alcohol fermentation phase, avoid air admission as far as possible, material compresses in right amount, and material can not compacting after 10 days, allows air admission, ethanol changes into acetic acid, behind the acetic fermentation 5 days, measure its acidity every day, reach 35 degree by this prescription acidity, no longer raise, stop fermentation.
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