CN103385963B - Chinese medicine preparation for treating angina pectoris caused by coronary heart disease - Google Patents

Abstract

The invention belongs to a medicine preparation, and particularly relates to a Chinese medicine preparation for treating angina pectoris caused by coronary heart disease. The Chinese medicine preparation comprises the following raw Chinese medicinal materials in parts by weight: 6-20 parts of radix puerariae, 6-12 parts of flos chrysanthemi, 3-10 parts of dried tangerine peel, 10-15 parts of semen cassiae, 10-15 parts of hawthorn, 6-15 parts of angelica sinensis, 10-15 parts of radix codonopsis, 8-12 parts of curnu cervi pantotrichum, 10-15 parts of manyprickle acanthopanax root, 6-15 parts of lotus seeds, 10-30 parts of poria cocos, 3-9 parts of ligusticum wallichii, 10-15 parts of radix astragali, 7-12 parts of fructus schizandrae, 10-15 parts of safflowers, and 10-15 parts of salviae miltiorrhizae. Proved by observing 98 cases, the total efficiency of patients with the confirmed angina pectoris caused by coronary heart disease is 90.8% after the Chinese medicine preparation is taken for one month.

Description

Treatment coronary heart disease causes anginal Chinese medicine preparation

Technical field

The invention belongs to a kind of pharmaceutical product, particularly a kind of coronary heart disease for the treatment of causes anginal Chinese medicine preparation.

Background technology

Angina pectoris is a kind of by coronary insufficiency, and cardiac muscle sharply causes the clinical disease that the squeezing of paroxysmal shirtfront is felt or pain is feature with anoxia with temporary transient ischemia.The outbreak of primary disease many tired, exciting, catch cold, be satiated with food, during smoking.

The most frequently used method is to take nitroglycerine tablets.In addition medicine also has beta-Blocking agent as propranolol, and calcium ion antagonist is as nifedipine, diltiazem.At present, nitroglycerin has had membranous patch and oral spray.Membranous patch is used in left front chest outward, and drug percutaneous skin evenly absorbs, and continues the antianginal effect of performance in 24 hours.Oral spray is little because of consumption, absorbs sooner, and side effect is little and be subject to patient and welcome.These two kinds of dosage form prices are more expensive above, are unfavorable for promoting the use of.SUXIAO JIUXIN WAN is Chinese medicine preparation, during angina pectoris attacks, take in 10-15 grain number minute and take effect, this medicine also can long-term taking. and other are as medicine long-term takings such as storax pill for treating coronary heart disease, FUFANG DANSHEN PIAN, Xinnao Shutongs, can play the effect of the logical coronary circulation of relaxing, generally according to self-condition, select wherein 1,2 kind.Though it is various in style that angina pectoris therapeutic effect is satisfied with medicine, though long-acting single nitro isosorbide can maintain nearly 20 hours of effect, but clinical practice still has certain disadvantage, and external product is expensive, and patient can not bear because the side effect such as headache, flush are many sometimes.

Summary of the invention

The object of the invention is to provide a kind of coronary heart disease for the treatment of and causes anginal Chinese medicine preparation.

Specifically, treatment coronary heart disease causes anginal Chinese medicine preparation, and it is made by following weight portion raw material of Chinese medicine:

Radix Puerariae 6-20, Flos Chrysanthemi 6-12, Pericarpium Citri Reticulatae 3-10; Semen Cassiae 10-15, Fructus Crataegi 10-15, Radix Angelicae Sinensis 6-15, Radix Codonopsis 10-15, Cornu Cervi Pantotrichum 8-12, Radix Et Caulis Acanthopanacis Senticosi 10-15, Semen Nelumbinis 6-15, Poria 10-30, Rhizoma Chuanxiong 3-9, the Radix Astragali 10-15, Fructus Schisandrae Chinensis 7-12, Flos Carthami 10-15, Radix Salviae Miltiorrhizae 10-15.

Preferential treatment coronary heart disease of recommending causes anginal Chinese medicine preparation, and it is to be made by following weight portion raw material of Chinese medicine:

Radix Puerariae 12, Flos Chrysanthemi 6, Pericarpium Citri Reticulatae 6; Semen Cassiae 12, Fructus Crataegi 12, Radix Angelicae Sinensis 11, Radix Codonopsis 12, Cornu Cervi Pantotrichum 10, Radix Et Caulis Acanthopanacis Senticosi 12, Semen Nelumbinis 9, Poria 20, Rhizoma Chuanxiong 5, the Radix Astragali 12, Fructus Schisandrae Chinensis 9, Flos Carthami 12, Radix Salviae Miltiorrhizae 12.

Described treatment coronary heart disease causes anginal Chinese medicine preparation, and it is to make pill or powder or capsule after all components is cleaned to mixing.

Each component effect of the present invention is as follows:

Radix Puerariae-expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, treating measles, yang invigorating antidiarrheal;

Flos Chrysanthemi-dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight;

Pericarpium Citri Reticulatae-drying dampness to eliminate phlegm, regulating qi-flowing for strengthening spleen;

Semen Cassiae-liver heat removing kidney tonifying, dispelling pathogenic wind for improving eyesight, blood pressure lowering relieving constipation;

Fructus Crataegi-promoting digestion and removing stagnation, antidiarrheal dysentery, dispelling the stagnated QI blood stasis dispelling, blood pressure lowering;

Radix Angelicae Sinensis-tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation;

Radix Codonopsis-invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid;

Radix Ginseng-QI invigorating emergency treatment of collapse, benefit strengthening spleen and lung, promoting the production of body fluid to quench thirst, the mind calming and mentality promoting;

Cornu Cervi Pantotrichum-kidney-replenishing, benefiting essence-blood, bone and muscle strengthening;

Radix Et Caulis Acanthopanacis Senticosi-replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization;

Semen Nelumbinis-spleen reinforcing antidiarrheal, tranquilizing by nourishing the heart, supplementing the kidney to control the nocturnal;

Poria-promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming;

Rhizoma Chuanxiong-blood-activating and qi-promoting, wind-expelling pain-stopping;

The Radix Astragali-tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, de-skin ulcer granulation promoting, inducing diuresis to remove edema;

Fructus Schisandrae Chinensis-astringing the lung, nourishing kidney, promote the production of body fluid, receive antiperspirant, arresting seminal emission;

Flos Carthami-invigorate blood circulation logical muscle, stasis-dispelling and pain-killing;

Radix Salviae Miltiorrhizae-blood circulation promoting and blood stasis dispelling, relieving restlessness are calmed the nerves, reducing swelling and alleviating pain.

Advantage of the present invention adopts natural material, has warming YANG activating QI, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving effect, and vascular plaque is had and reduces or disappear, and makes coronary artery unobstructed, thereby makes patients with coronary heart disease reach the therapeutic purposes of rehabilitation.Its compatibility is comprehensive simultaneously, and coronary heart disease is caused to angina pectoris treatment is rapid-action, and relatively Western medicine toxic and side effects is less.

The specific embodiment

Formula 1: Radix Puerariae 6, Flos Chrysanthemi 12, Pericarpium Citri Reticulatae 3; Semen Cassiae 15, Fructus Crataegi 10, Radix Angelicae Sinensis 15, Radix Codonopsis 10, Cornu Cervi Pantotrichum 12, Radix Et Caulis Acanthopanacis Senticosi 10, Semen Nelumbinis 15, Poria 10, Rhizoma Chuanxiong 9, the Radix Astragali 10, Fructus Schisandrae Chinensis 12, Flos Carthami 10, Radix Salviae Miltiorrhizae 15.

Formula 2: Radix Puerariae 20, Flos Chrysanthemi 6, Pericarpium Citri Reticulatae 10; Semen Cassiae 10, Fructus Crataegi 15, Radix Angelicae Sinensis 6, Radix Codonopsis 15, Cornu Cervi Pantotrichum 8, Radix Et Caulis Acanthopanacis Senticosi 15, Semen Nelumbinis 6, Poria 30, Rhizoma Chuanxiong 3, the Radix Astragali 15, Fructus Schisandrae Chinensis 7, Flos Carthami 15, Radix Salviae Miltiorrhizae 10.

Formula 3: Radix Puerariae 12, Flos Chrysanthemi 6, Pericarpium Citri Reticulatae 6; Semen Cassiae 12, Fructus Crataegi 12, Radix Angelicae Sinensis 11, Radix Codonopsis 12, Cornu Cervi Pantotrichum 10, Radix Et Caulis Acanthopanacis Senticosi 12, Semen Nelumbinis 9, Poria 20, Rhizoma Chuanxiong 5, the Radix Astragali 12, Fructus Schisandrae Chinensis 9, Flos Carthami 12, Radix Salviae Miltiorrhizae 12.

Preparation method: mix after above-mentioned each prescription drug cleaning-drying, pulverize and to make pill or powder or capsule and all can.

Instructions of taking: every day three times, each 6-9 gram of former medicine.

Treatment by Chinese herbs angina pectoris clinical report of the present invention

From in January, 2013, observe altogether coronary heart disease in June, 2011 and cause angina pectoris 98 examples, observed result is as follows:

One, physical data

98 routine patients with coronary heart disease male 56, women 42 people, 49-78 years old ages, 79 routine complicated hypertension histories, the course of disease is mostly 4-9 years, 48 routine > 10 years.

Treating Stable Angina Pectoris of Coronary Artery Disease 61 examples, unstable angina 19 examples, angina pectoris 18 examples after heart infarction.Angina pectoris degree is sought unity of standard according to domestic Angina Pectoris from Coronary Artery Disease with Therapy of Combination of TCM with Western Medicine cooperative groups, slight 39 examples; Moderate 47 examples; Severe 12 examples.

Two, observational technique

Fill in unified observation table and observed by special messenger, stop any at least one week of angina pectoris medicine, 69 examples are observed cases need to contain nitroglycerin, 3 slices/day of < because of the state of an illness simultaneously.Nitroglycerin tongue needs the item records such as the every consumption per day of meter (sheet/day) treatment before measurement platelet white blood cell count, GPT, blood glucose, BUN, creatinine, routine urinalysis, cholesterol, triglyceride and high density lipoprotein, electrocardiogram containing exception.

Each oral the inventive method of all patients: every day three times, each 6-9 gram of former medicine.Preparation of the present invention is: Radix Puerariae 12, Flos Chrysanthemi 6, Pericarpium Citri Reticulatae 6; Semen Cassiae 12, Fructus Crataegi 12, Radix Angelicae Sinensis 11, Radix Codonopsis 12, Cornu Cervi Pantotrichum 10, Radix Et Caulis Acanthopanacis Senticosi 12, Semen Nelumbinis 9, Poria 20, Rhizoma Chuanxiong 5, the Radix Astragali 12, Fructus Schisandrae Chinensis 9, Flos Carthami 12, Radix Salviae Miltiorrhizae 12.All components is in a gram weight.After each prescription drug cleaning-drying, mix, pulverizing is made powder and is taken.

Within one week, be a course for the treatment of, the above-mentioned item inspection of check after treatment, the unification of observation table is gathered to array data by special messenger makes brief summary.

Three, curative effect judging standard

Effective: " breathe hard, pained transference cure or obviously alleviate, other double disease and electrocardiogram are stable or progressive to some extent.

Invalid: all diseases and electrocardiogram are unchanged;

Four, result

1, therapeutic effect: effective 89 examples, no effect 9.It is 90.8% that the present invention treats angina pectoris clinical symptoms curative effect obvious effective rate;

2, adverse reactions of patients.In 98 examples, only 1 example has epigastric discomfort to feel sick, and loss of appetite untoward reaction, does not affect medication treatment, alleviates gradually disappearance in drug administration process, abnormal without other.

3, before and after all other treatments, lab testing has no significant change.

Claims (3)

1. treatment coronary heart disease causes anginal Chinese medicine preparation, it is characterized in that being made by following weight portion raw material of Chinese medicine:

Radix Puerariae 6-20, Flos Chrysanthemi 6-12, Pericarpium Citri Reticulatae 3-10; Semen Cassiae 10-15, Fructus Crataegi 10-15, Radix Angelicae Sinensis 6-15, Radix Codonopsis 10-15, Cornu Cervi Pantotrichum 8-12, Radix Et Caulis Acanthopanacis Senticosi 10-15, Semen Nelumbinis 6-15, Poria 10-30, Rhizoma Chuanxiong 3-9, the Radix Astragali 10-15, Fructus Schisandrae Chinensis 7-12, Flos Carthami 10-15, Radix Salviae Miltiorrhizae 10-15.

2. treatment coronary heart disease according to claim 1 causes anginal Chinese medicine preparation, it is characterized in that being made by following weight portion raw material of Chinese medicine:

Radix Puerariae 12, Flos Chrysanthemi 6, Pericarpium Citri Reticulatae 6; Semen Cassiae 12, Fructus Crataegi 12, Radix Angelicae Sinensis 11, Radix Codonopsis 12, Cornu Cervi Pantotrichum 10, Radix Et Caulis Acanthopanacis Senticosi 12, Semen Nelumbinis 9, Poria 20, Rhizoma Chuanxiong 5, the Radix Astragali 12, Fructus Schisandrae Chinensis 9, Flos Carthami 12, Radix Salviae Miltiorrhizae 12.

3. treatment coronary heart disease according to claim 1 causes anginal Chinese medicine preparation, after it is characterized in that all components cleaning to mix, makes pill or powder or capsule.