CN105250998A - Biological agent for reducing blood pressure and preparation method of biological agent - Google Patents
Biological agent for reducing blood pressure and preparation method of biological agent Download PDFInfo
- Publication number
- CN105250998A CN105250998A CN201510728534.0A CN201510728534A CN105250998A CN 105250998 A CN105250998 A CN 105250998A CN 201510728534 A CN201510728534 A CN 201510728534A CN 105250998 A CN105250998 A CN 105250998A
- Authority
- CN
- China
- Prior art keywords
- extract
- preparation
- parts
- blood pressure
- biological preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a biological agent for reducing blood pressure and a preparation method of the biological agent. The biological agent is prepared from the following components in parts by weight: 20 to 30 parts of nattokinase, 15 to 30 parts of eucommia ulmoides leaf extract, 10 to 20 parts of pueraria root extract and 10 to 20 parts of wild chrysanthemum extract; during preparation, various components are weighed according to weight parts and are placed into a three-dimensional mixer for mixing for 15 to 25 minutes; the mixture passes through a sieve with 40 to 80 meshes, and the operation is repeated for 2 to 3 times to obtain the biological agent. Compared with the prior art, the biological agent disclosed by the invention has the advantages that blood vessel elasticity can be improved, and the blood vessel is rejuvenated; meanwhile, thrombolysis in blood is promoted, blood fat is reduced and blood quality is improved; the biological agent has stabilizing and pressure reducing actions, and is simple in preparation process, quick in response, wide in application people, low in dose, fewer in side effects, good in stability, long in shelf life, convenient in administration, easy to carry, low in cost and suitable for large-scale production.
Description
Technical field
The invention belongs to biological pharmacy technical field, relate to a kind of biological preparation for blood pressure lowering and preparation method thereof.
Background technology
As everyone knows, hypertension is the high risk factor of cardiovascular and cerebrovascular disease.Hypertension a kind ofly continues to raise for the chronic disease of main manifestations with arteriotony, one of principal pathogenetic reason is due to human peripheral arteriolospasm, human peripheral small artery resistance is strengthened, thus cause blood pressure to increase, form hypertension, often cause the pathological changes of the vitals such as the heart, brain, kidney and occur corresponding consequence.At present, hypertension prevalence and mortality rate thereof and disability rate are all in quick growth, and its development trend makes us extremely worrying.Chinese cardiovascular diseases's report in 2015 is pointed out, China 15 years old and above population Prevalence of Hypertension, up to 26.39%, estimate that hyperpietic is close to hundred million.It is particularly worth mentioning that, the age of hyperpietic is rejuvenation.Epidemiological study shows, within 25 years old to 34 years old, age bracket prevalence reaches 25.19%.Therefore, China's hypertension development trend is very pessimistic, and it is very heavy that it prevents and treats task.
In hypertensive treatment, people widely use various Western medicine depressor, though it can meet general blood pressure lowering requirement, also have obvious side effect.Because Western medicine blood pressure lowering is all based on blood vessel dilating, and blood vessel is in continuous process of expansion, and himself elasticity dies down and hardens, and therefore, the people of life-time service depressor easily causes sclerosis of blood vessels and breaks, and causes the disease such as cerebral vessels embolism, apoplexy.Therefore, Western medicine is not suitable for permanent use.
Authorization Notice No. is the Chinese medicine preparation that the Chinese invention patent of CN102949599B discloses a kind of blood pressure lowering, is made up of the Chinese crude drug of following weight portion: Flos Chrysanthemi Indici 10 parts, Herba Lysimachiae 10 parts, Semen Sesami Nigrum 10 parts, Arillus Longan 10 parts, Fructus Mori 10 parts, Radix Rehmanniae 5 parts, Radix Ophiopogonis 5 parts, Radix Trichosanthis 5 parts, the Radix Astragali 5 parts, Fructus Lycii 5 parts, Radix Puerariae 5 parts, Radix Ginseng Rubra 5 parts, 5 parts, Poria, Cortex Moutan 5 parts, Fructus Schisandrae Chinensis 5 parts, Semen Ziziphi Spinosae 3 parts, Semen Platycladi 3 parts, Cortex Albiziae 3 parts, Herba Dendrobii 3 parts, Fructus Lycii 3 parts, Fructus Ligustri Lucidi 3 parts, Bulbus Lilii 3 parts, Fructus Toosendan 3 parts.The technical scheme of above-mentioned patent disclosure, Chinese medicinal components forms various, though have certain antihypertensive effect, but Financial cost is higher, compared to above-mentioned patent, each component clear efficacy of the present invention, the mechanism of action is clear and definite, have too many levels to work in coordination with onset, the onset time of biological preparation of the present invention is short, and effect is more remarkable.
Summary of the invention
Object of the present invention is exactly provide one can improve blood vessel elasticity to overcome defect that above-mentioned prior art exists, thrombosis in lysed blood, and reduce biological preparation for blood pressure lowering of blood fat and preparation method thereof.
Object of the present invention can be achieved through the following technical solutions:
For a biological preparation for blood pressure lowering, this biological preparation comprises following component and weight portion content: nattokinase 20-30 part, Folium Eucommiae extract 15-30 part, Radix Puerariae extract 10-20 part and Flos Chrysanthemi Indici extract 10-20 part.
Preferably, described biological preparation comprises following component and weight portion content: nattokinase 25-30 part, Folium Eucommiae extract 18-24 part, Radix Puerariae extract 16-18 part and Flos Chrysanthemi Indici extract 16-18 part.
Vitamin K in described nattokinase
2content < 10PPM, and the activity of described nattokinase is 4000-8000Fu.
The preparation method of described Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained described Folium Eucommiae extract.
The preparation method of described Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained described Radix Puerariae extract.
The preparation method of described Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained described Flos Chrysanthemi Indici extract.
The instructions of taking of described biological preparation is: daily secondary, each serving with 900-1200mg.
For a preparation method for the biological preparation of blood pressure lowering, the method specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 20-30 part, Folium Eucommiae extract 15-30 part, Radix Puerariae extract 10-20 part and Flos Chrysanthemi Indici extract 10-20 part;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 15-25min, crosses 40-80 mesh sieve, repeats 2-3 time, i.e. obtained described biological preparation.
In the formula of biological preparation of the present invention:
Nattokinase is a kind of Proteinkinase, it is a kind of serine protease produced by Bacillus subtilis natto from Traditional Japanese Food in soybean isoflavone by natto strain, it produces tissue-type plasminogen activator (t-PA) by stimulating vascular endothelial cell, Plasminogen activation is fibrinolysin by t-PA, solution fibrin, direct thrombus; Activate the prourokinase in human body for urokinase, urokinase and t-PA together plasminogen activation, reaches thrombolytic effect simultaneously.Nattokinase, directly dissolving thrombosed while, can also activate the thrombolytic ability strengthening human body self, thus play the thrombolytic effect of long lasting and stable.
Folium Eucommiae extract is rich in chlorogenic acid; chlorogenic acid can scavenging free radicals; self also has good non-oxidizability; it is by scavenging free radicals and anti peroxidation of lipid; can vascular endothelial cell be protected, and then play a role preventing and treating in atherosclerosis, thrombotic disease and hypertension etc.
Containing more Radix Puerariae flavone and puerarin in Radix Puerariae extract, energy is coronary artery dilator obviously, directly lax vascular smooth muscle, especially puerarin, it is a kind of beta-blockers, has obvious hypotensive effect, the blood flow tool of around blood capillary and cerebrovascular disorders is improved significantly, reduce vascular resistance, increasing blood flow, to reducing blood pressure, there is good effect.
Flos Chrysanthemi Indici extract has dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight, heat-clearing toxin-expelling functions, it has coronary artery dilating, increase the effect of coronary flow, and vasomotor center can be suppressed to reduce blood pressure by antiadrenergic drug, expansion peripheral blood vessel, there is good efficacy of antihypertensive treatment.
The biological preparation mechanism of action of the present invention is: nattokinase thrombus improves blood viscosity; Folium Eucommiae protection vascular endothelial cell, improves blood vessel elasticity; Radix Puerariae, Flos Chrysanthemi Indici are by improving angiotensin mechanism to carry out collaborative hypotensive activity.
Biological preparation of the present invention can be used for the medicine preparing blood pressure lowering, and the dosage form of employing can be tablet, granule, pill, powder, the one sucked in agent or powder.
Compared with prior art, the present invention has following characteristics:
1) between each component, there is good synergism, blood vessel elasticity can be improved, make blood vessel " rejuvenation ", promote thromboembolism in blood simultaneously, reduce blood fat, improve blood quality, blood vessel feritin-blood vessel can also be improved and to rise suddenly and sharply systemic-function, cell " is easily changed ", reaches the effect of stable blood pressure lowering;
2), in biological preparation component of the present invention, nattokinase can effective thrombus, and improves blood viscosity; Folium Eucommiae extract then can protect vascular endothelial cell, improves blood vessel elasticity; Radix Puerariae extract, Flos Chrysanthemi Indici extract are by improving angiotensin mechanism to carry out collaborative hypotensive activity;
3) preparation technology is simple, instant effect, and be suitable for crowd extensive, dosage is few, few side effects, good stability, long shelf-life, takes medicine convenient and is easy to carry about with one, with low cost, is applicable to large-scale production.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1:
The present embodiment is used for the biological preparation of blood pressure lowering, comprises following component and weight portion content: nattokinase 25 parts, Folium Eucommiae extract 20 parts, Radix Puerariae extract 16 parts and Flos Chrysanthemi Indici extract 18 parts.
Wherein, vitamin K in nattokinase
2content < 10PPM, and the activity of nattokinase is 8000Fu.
The preparation method of Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained Folium Eucommiae extract.
The preparation method of Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Radix Puerariae extract.
The preparation method of Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Flos Chrysanthemi Indici extract.
In actual fabrication process, mainly comprise the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 25 parts, Folium Eucommiae extract 20 parts, Radix Puerariae extract 16 parts and Flos Chrysanthemi Indici extract 18 parts;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 25min, crosses 80 mesh sieves, repeats 2 times.
When carrying out clinical research, select 30 examples to suffer from hypertensive patient, the age 35-65 year between, take group and adopt this enforcement biological preparation tablet.
Take group experimenter and take 2 times everyone every day, each serving with 1000mg, use warm water delivery service.Duration of test normal diet, does not change original dietary habit, and the medicine of other blood pressure lowerings of stopping using and health product, viewing duration is 30 days.
Result of the test is as shown in table 1-4:
Table 1: patient takes front and back blood pressure and compares
| Group | Number of cases | Before treatment | After treatment | Blood pressure decreasing value |
| Take group | 30 | 156.50 ± 10.27 systolic pressures | 126.00 ± 8.97* systolic pressure | 30.50±1.30* |
| 30 | 92.50 ± 8.35 diastolic pressures | 77.65 ± 4.40* diastolic pressure | 14.85±3.95* |
Table 2: patient takes the comparison that front and back blood pressure reduces percentage of amplitude
| Group | Number of cases | Systolic pressure reduces amplitude (%) | Diastolic pressure reduces amplitude (%) |
| Take group | 30 | 19.49±0.64 | 16.54±4.42 |
Table 3: patient takes front and back Blood Lipid (mg/dl)
| T-CHOL | Triglyceride | |
| Before treatment | 211.40±53.71 | 263.25±108.62 |
| After treatment | 179.65±32.24* | 151.05±100.19* |
Note: take group 30 example
Table 4: patient takes the change (pg/ml) of Plasma Before And After endothelin-1
| Group | Number of cases | Before taking | After taking |
| Take group | 30 | 131.64±76.27 | 82.36±55.14* |
From above-mentioned result of the test, when the present embodiment biological preparation is used for Treatment of Hypertension, the antihypertensive effect taking group is obvious, it is 19.49 ± 0.64% that systolic pressure reduces amplitude, it is 16.54 ± 4.42% that diastolic pressure reduces amplitude, and in T-CHOL and triglyceride, take the index of group patient by remarkable reduction.As can be seen here, biological preparation of the present invention has significant antihypertensive effect.
Embodiment 2:
The present embodiment is used for the biological preparation of blood pressure lowering, comprises following component and weight portion content: nattokinase 20 parts, Folium Eucommiae extract 15 parts, Radix Puerariae extract 10 parts and Flos Chrysanthemi Indici extract 10 parts.
Wherein, vitamin K in nattokinase
2content < 10PPM, and the activity of nattokinase is 4000Fu.
The preparation method of Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained Folium Eucommiae extract.
The preparation method of Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Radix Puerariae extract.
The preparation method of Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Flos Chrysanthemi Indici extract.
The preparation method of the present embodiment biological preparation specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 20-30 part, Folium Eucommiae extract 15-30 part, Radix Puerariae extract 10-20 part and Flos Chrysanthemi Indici extract 10-20 part;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 15-25min, crosses 40-80 mesh sieve, repeats 2-3 time, i.e. obtained biological preparation.
The present embodiment biological preparation can be used for the medicine preparing blood pressure lowering, and the dosage form of employing is granule, and instructions of taking is: daily secondary, each serving with 1200mg.
Embodiment 3:
The present embodiment is used for the biological preparation of blood pressure lowering, comprises following component and weight portion content: nattokinase 30 parts, Folium Eucommiae extract 30 parts, Radix Puerariae extract 20 parts and Flos Chrysanthemi Indici extract 20 parts.
Wherein, vitamin K in nattokinase
2content < 10PPM, and the activity of nattokinase is 5000Fu.
The preparation method of Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained Folium Eucommiae extract.
The preparation method of Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Radix Puerariae extract.
The preparation method of Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Flos Chrysanthemi Indici extract.
The preparation method of the present embodiment biological preparation specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 30 parts, Folium Eucommiae extract 30 parts, Radix Puerariae extract 20 parts and Flos Chrysanthemi Indici extract 20 parts;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 20min, crosses 60 mesh sieves, repeats 2 times, i.e. obtained biological preparation.
The present embodiment biological preparation can be used for the medicine preparing blood pressure lowering, and the dosage form of employing is pill, and instructions of taking is: daily secondary, each serving with 900mg.
Embodiment 4:
The present embodiment is used for the biological preparation of blood pressure lowering, comprises following component and weight portion content: nattokinase 27 parts, Folium Eucommiae extract 24 parts, Radix Puerariae extract 18 parts and Flos Chrysanthemi Indici extract 18 parts; .
Wherein, vitamin K in nattokinase
2content < 10PPM, and the activity of nattokinase is 6000Fu.
The preparation method of Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained Folium Eucommiae extract.
The preparation method of Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Radix Puerariae extract.
The preparation method of Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Flos Chrysanthemi Indici extract.
The preparation method of the present embodiment biological preparation specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 27 parts, Folium Eucommiae extract 24 parts, Radix Puerariae extract 18 parts and Flos Chrysanthemi Indici extract 18 parts;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 20min, crosses 60 mesh sieves, repeats 2 times, i.e. obtained biological preparation.
The present embodiment biological preparation can be used for the medicine preparing blood pressure lowering, and the dosage form of employing is powder, and instructions of taking is: daily secondary, each serving with 1000mg.
Embodiment 5:
The present embodiment is used for the biological preparation of blood pressure lowering, comprises following component and weight portion content: nattokinase 28 parts, Folium Eucommiae extract 18 parts, Radix Puerariae extract 17 parts and Flos Chrysanthemi Indici extract 16 parts.
Wherein, vitamin K in nattokinase
2content < 10PPM, and the activity of nattokinase is 6000Fu.
The preparation method of Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained Folium Eucommiae extract.
The preparation method of Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Radix Puerariae extract.
The preparation method of Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Flos Chrysanthemi Indici extract.
The preparation method of the present embodiment biological preparation specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 28 parts, Folium Eucommiae extract 18 parts, Radix Puerariae extract 17 parts and Flos Chrysanthemi Indici extract 16 parts;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 15min, crosses 70 mesh sieves, repeats 2 times, i.e. obtained biological preparation.
The present embodiment biological preparation can be used for the medicine preparing blood pressure lowering, and the dosage form of employing is for sucking agent, and instructions of taking is: daily secondary, each serving with 1100mg.
Embodiment 6:
The present embodiment is used for the biological preparation of blood pressure lowering, comprises following component and weight portion content: nattokinase 24 parts, Folium Eucommiae extract 26 parts, Radix Puerariae extract 12 parts and Flos Chrysanthemi Indici extract 15 parts.
Wherein, vitamin K in nattokinase
2content < 10PPM, and the activity of nattokinase is 6000Fu.
The preparation method of Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained Folium Eucommiae extract.
The preparation method of Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Radix Puerariae extract.
The preparation method of Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, obtains extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained Flos Chrysanthemi Indici extract.
The preparation method of the present embodiment biological preparation specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 24 parts, Folium Eucommiae extract 26 parts, Radix Puerariae extract 12 parts and Flos Chrysanthemi Indici extract 15 parts;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 25min, crosses 50 mesh sieves, repeats 2 times, i.e. obtained biological preparation.
The present embodiment biological preparation can be used for the medicine preparing blood pressure lowering, and the dosage form of employing is powder, and instructions of taking is: daily secondary, each serving with 1000mg.
Claims (8)
1. for a biological preparation for blood pressure lowering, it is characterized in that, this biological preparation comprises following component and weight portion content: nattokinase 20-30 part, Folium Eucommiae extract 15-30 part, Radix Puerariae extract 10-20 part and Flos Chrysanthemi Indici extract 10-20 part.
2. a kind of biological preparation for blood pressure lowering according to claim 1, it is characterized in that, this biological preparation comprises following component and weight portion content: nattokinase 25-30 part, Folium Eucommiae extract 18-24 part, Radix Puerariae extract 16-18 part and Flos Chrysanthemi Indici extract 16-18 part.
3. a kind of biological preparation for blood pressure lowering according to claim 1, is characterized in that, vitamin K in described nattokinase
2content < 10PPM, and the activity of described nattokinase is 4000-8000Fu.
4. a kind of biological preparation for blood pressure lowering according to claim 1, it is characterized in that, the preparation method of described Folium Eucommiae extract is: joined by Folium Eucommiae in the water of 6-8 times amount, in 50-70 DEG C of soak extraction 2 times, extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.08g/cm
3, obtain concentrated solution, then concentrated solution is placed in adsorbent resin, adopt 50-70wt% alcoholic solution eluting, dry, i.e. obtained described Folium Eucommiae extract.
5. a kind of biological preparation for blood pressure lowering according to claim 1, it is characterized in that, the preparation method of described Radix Puerariae extract is: joined by Radix Puerariae in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.07-1.09g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained described Radix Puerariae extract.
6. a kind of biological preparation for blood pressure lowering according to claim 1, it is characterized in that, the preparation method of described Flos Chrysanthemi Indici extract is: joined by Flos Chrysanthemi Indici in the 60-80wt% alcoholic solution of 6-8 times amount, in 50-70 DEG C of reflux, extract, 2 times, extracting solution, then extracting solution is concentrated into density in 55-65 DEG C is 1.05-1.07g/cm
3, obtain concentrated solution, by vacuum drying, i.e. obtained described Flos Chrysanthemi Indici extract.
7. a kind of biological preparation for blood pressure lowering according to claim 1, is characterized in that, the instructions of taking of described biological preparation is: daily secondary, each serving with 900-1200mg.
8., as claimed in claim 1 for a preparation method for the biological preparation of blood pressure lowering, it is characterized in that, the method specifically comprises the following steps:
(1) get the raw materials ready by following component and weight portion:
Nattokinase 20-30 part, Folium Eucommiae extract 15-30 part, Radix Puerariae extract 10-20 part and Flos Chrysanthemi Indici extract 10-20 part;
(2) step (1) each component taken by weight, insert three-dimensional mixer, mixing 15-25min, crosses 40-80 mesh sieve, repeats 2-3 time, i.e. obtained described biological preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510728534.0A CN105250998A (en) | 2015-10-30 | 2015-10-30 | Biological agent for reducing blood pressure and preparation method of biological agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510728534.0A CN105250998A (en) | 2015-10-30 | 2015-10-30 | Biological agent for reducing blood pressure and preparation method of biological agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250998A true CN105250998A (en) | 2016-01-20 |
Family
ID=55091122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510728534.0A Pending CN105250998A (en) | 2015-10-30 | 2015-10-30 | Biological agent for reducing blood pressure and preparation method of biological agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250998A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020262005A1 (en) * | 2019-06-24 | 2020-12-30 | 小林製薬株式会社 | Solid composition containing processed product of du-zhong |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008571A (en) * | 2010-11-26 | 2011-04-13 | 山东省中医药研究院 | Traditional Chinese medicine composition as well as preparation method and application thereof |
| CN102068488A (en) * | 2011-01-25 | 2011-05-25 | 山东省科学院生物研究所 | Traditional Chinese medicinal composition and preparation method for granules thereof |
| CN103223033A (en) * | 2013-05-22 | 2013-07-31 | 武汉真福医药科技发展有限公司 | Novel natto health-care composite and preparation method and application thereof |
| CN103349058A (en) * | 2013-07-29 | 2013-10-16 | 安徽燕之坊食品有限公司 | Multigrain food with health preserving and blood pressure decreasing function |
| CN104172145A (en) * | 2013-05-20 | 2014-12-03 | 山东东阿阿胶股份有限公司 | Compound donkey-hide gelatin composition promoting blood health, and preparation method and application thereof |
| CN104546992A (en) * | 2015-01-30 | 2015-04-29 | 四川九章生物科技有限公司 | Folium cortex eucommiae extract as well as preparation method and application thereof |
-
2015
- 2015-10-30 CN CN201510728534.0A patent/CN105250998A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008571A (en) * | 2010-11-26 | 2011-04-13 | 山东省中医药研究院 | Traditional Chinese medicine composition as well as preparation method and application thereof |
| CN102068488A (en) * | 2011-01-25 | 2011-05-25 | 山东省科学院生物研究所 | Traditional Chinese medicinal composition and preparation method for granules thereof |
| CN104172145A (en) * | 2013-05-20 | 2014-12-03 | 山东东阿阿胶股份有限公司 | Compound donkey-hide gelatin composition promoting blood health, and preparation method and application thereof |
| CN103223033A (en) * | 2013-05-22 | 2013-07-31 | 武汉真福医药科技发展有限公司 | Novel natto health-care composite and preparation method and application thereof |
| CN103349058A (en) * | 2013-07-29 | 2013-10-16 | 安徽燕之坊食品有限公司 | Multigrain food with health preserving and blood pressure decreasing function |
| CN104546992A (en) * | 2015-01-30 | 2015-04-29 | 四川九章生物科技有限公司 | Folium cortex eucommiae extract as well as preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 唐晓玲: "杜仲叶药理作用新进展", 《光明中医》 * |
| 邓立新: "新一代溶栓药物纳豆激酶", 《现代中西医结合杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020262005A1 (en) * | 2019-06-24 | 2020-12-30 | 小林製薬株式会社 | Solid composition containing processed product of du-zhong |
| JP2021001155A (en) * | 2019-06-24 | 2021-01-07 | 小林製薬株式会社 | Solid composition containing processed eucommia ulmoides |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107929420A (en) | Improve energy and blood of human body function and improve the Chinese medicine composition and detection method of immunity | |
| CN102106957A (en) | Chinese medicinal composition for treating hyperlipidemia | |
| WO2016015391A1 (en) | Pharmaceutical composition for treating cardiovascular or cerebrovascular diseases and preparation method therefor | |
| CN101664136A (en) | Method for preparing high-activity nutrient natto and application of high-activity nutrient natto | |
| CN1840166A (en) | Modern Chinese medicinal oral liquid of 'Wen Dan Tang' and preparation method thereof | |
| CN105031301A (en) | Anti-tumor traditional Chinese medicine composition and preparation method thereof | |
| CN105029568A (en) | Black garlic beverage and preparation method thereof | |
| CN103451084B (en) | Hangover liver protection vinegar and preparation method and application thereof | |
| CN106177053A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae | |
| CN103933487A (en) | Compound traditional Chinese medicament for treating depression | |
| CN109090604A (en) | A kind of composition with auxiliary hyperglycemic function, health food and preparation method thereof | |
| CN105250998A (en) | Biological agent for reducing blood pressure and preparation method of biological agent | |
| CN106173605A (en) | A kind of Hyperglycemic health care compositions comprising Radix Puerariae and Herba Dendrobii | |
| CN102125662B (en) | Compound traditional Chinese medicine for treating apoplexia and preparation method and application thereof | |
| CN101244084B (en) | Sobering-up agent of pearl oyster and preparation thereof | |
| CN105267889A (en) | Traditional Chinese medicine preparation for treating hyperlipoidemia | |
| CN1232267C (en) | Compound plant medicine and its application | |
| CN104922295A (en) | Blood-nourishing and blood-enriching traditional Chinese medicine composition | |
| CN115040612A (en) | Composition for regulating hypertension and preparation method thereof | |
| CN107805577A (en) | A kind of preparation method of Jewel orchid healthcare wine | |
| CN1232693A (en) | Health beverage for preventing and curing hypertension and hyperlipemia | |
| CN109820924A (en) | A kind of preparation method of the separation and Extraction effective component from grape pip | |
| CN102599501B (en) | Healthcare Hongyang capsule or tablet product for lowering lipid and protecting liver | |
| CN114009760B (en) | Composition containing dried orange peel enzymolysis powder and health-care compound effervescent tablet | |
| CN107788180A (en) | A kind of health protecting tea of stable hypotensive and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160120 |