CN102106957A - Chinese medicinal composition for treating hyperlipidemia - Google Patents
Chinese medicinal composition for treating hyperlipidemia Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating hyperlipidemia, which relates to a Chinese medicinal composition. The Chinese medicinal composition solves the common problems of more ingredients and unreliable quality caused by complicated manufacturing process in the conventional traditional Chinese medicine for reducing blood fat. The Chinese medicinal composition is prepared from tuber fleeceflower root, hawthorn, wild chrysanthemum, cassia seed, liquoric root, Chinese wolfberry, Chinese yam, oriental waterplantain rhizome, twotooth achyranthes root and red sage root. The Chinese medicinal composition for treating the hyperlipidemia is prepared by mixing traditional Chinese medicines based on traditional Chinese medicine theory; and compared with the conventional Chinese medicinal preparation for treating the hyperlipidemia, the Chinese medicinal composition has fewer traditional Chinese medicine ingredients, is scientific in mixing and prepared from widely available raw materials, does not contain excipients, is not complicatedly manufactured, can be directly taken when crushed and then prepared into capsules, is low in cost, reliable in quality and more suitable for promotion and use, and has no toxic or side effect.
Description
Technical field
The present invention relates to Chinese medicine composition.
Background technology
Hyperlipidemia is meant that lipid metabolism or running make one or more lipids of blood plasma be higher than normal value unusually, it is a kind of systemic disease, be meant that blood cholesterol (TC) and/or triglyceride (TG) are too high or HDL-C (HDL-C) is low excessively, modern medicine is referred to as dyslipidemia.
Hyperlipidemia is commonly encountered diseases, the frequently-occurring disease of person in middle and old age's metabolic disease, is the principal element that causes coronary heart disease, arteriosclerosis, cerebral thrombosis and cerebral hemorrhage.Owing to high caloric diet, activity reduced in addition in recent years, and hyperlipidemia is tending towards rejuvenation, is threatening people's health, has caused common concern.
At present, the types of drugs of blood fat reducing is various, mainly is divided into Chinese medicine and Western medicine two big classes.The Western medicine side effect is big, all might cause myositis or brain soldier as the lipid lowerers of Statins and Bei Te class.Chinese medicine blood fat reducing class types of drugs is many, but the ubiquity drug ingredient is assorted, needs in the manufacturing process to soak, boil, extract, filter, concentrate or add adjuvant, and makes the shortage supervision, causes quality unreliable.
Summary of the invention
The Chinese medicine ubiquity composition that the objective of the invention is in order to solve existing blood fat reducing is many, and complex manufacturing process causes the insecure problem of quality, and a kind of Chinese medicine composition for the treatment of hyperlipidemia is provided.
The Chinese medicine composition of treatment hyperlipidemia is made up of the Radix Polygoni Multiflori of 20～30g, the Fructus Crataegi of 15～25g, the Flos Chrysanthemi Indici of 10～20g, the Semen Cassiae of 10～20g, the Radix Glycyrrhizae of 10～20g, the Fructus Lycii of 15～25g, the Rhizoma Dioscoreae of 10～20g, the Rhizoma Alismatis of 15～25g, the Radix Achyranthis Bidentatae of 20～30g and the Radix Salviae Miltiorrhizae of 10～20g.
The Chinese medicine composition of treatment hyperlipidemia is to be the Chinese medicine compound compatibility that carry out on the basis with the theory of Chinese medical science among the present invention, with respect to the Chinese medicine preparation of existing treatment hyperlipidemia, Chinese medicine composition of the present invention is few, the compatibility science, and raw material sources are extensive, do not add adjuvant, need not complicated making, make capsule after the pulverizing, can directly take, cost is low, have no side effect, reliable in quality is more suitable for promoting the use of.
It is as follows that the present invention treats in the Chinese medicine composition of hyperlipidemia each medicine operation mechanism:
Radix Polygoni Multiflori: nature and flavor are sweet, bitter, puckery, tepor; Return liver, the heart, kidney channel; Invigorating the liver and kidney, benefiting essence-blood, relieving constipation Compendium of Material Medica " the liver benefiting that nourishes blood, controlling nocturnal emission with astringent drugs kidney tonifying are tonic medicine "; Hyperlipidemia is mainly in the old people, comes to one's autumn, and kidney qi declines, so be aided with the invigorating the liver and kidney of the Radix Polygoni Multiflori, the benefiting essence-blood effect; Modern study finds that Radix Polygoni Multiflori can improve the ability of hepatocyte conversion and metabolism cholesterol, scalable serum cholesterol, blood sugar lowering.
Fructus Crataegi: acid is sweet, tepor; Return spleen, stomach, Liver Channel; Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis disappear fat, eliminate the phlegm wetly, adjust lipid metabolism, eliminate effects such as arteriosclerosis plaque.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, suffering are returned lung, Liver Channel; Heat-clearing and toxic substances removing, detumescence; Effect antibacterial, blood pressure lowering is arranged; But the diabetes-alleviating patient uses normal dysentery, the edema symptom that occurs of fat-reducing medicament.
Semen Cassiae: salty flat being slightly cold, return liver, large intestine channel; Clearing away heat to improve acuity of vision, the flat gastric qi of closing.
Radix Glycyrrhizae: Radix Glycyrrhizae energy invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, cushion toxicity, coordinating the actions of various ingredients in a prescription.
Fructus Lycii: kidney-tonifying sperm-generating, nourishing the liver to improve visual acuity is calmed the nerves; The treating the liver kidney yin is lost, and quenches one's thirst lung moistening.
Rhizoma Dioscoreae: sweet in the mouth, property is flat; Tonify without causing stagnation, not hot not dry, can enriching spleen-QI and stomach reinforcing the moon; Also contain mucus protein, vitamin and trace element have the effect of blood sugar lowering, can effectively stop the precipitation of blood fat in blood vessel wall, and prevention painstaking effort disease obtains the mind calming and mentality promoting, effect of prolonging life.
Rhizoma Alismatis: sweet in the mouth, cold in nature, return kidney, urinary bladder channel; Support the five internal organs, physical strength profiting has blood fat reducing, anti-fatty liver and anti-obesic action; Hypercholesterolemia there are tangible cholesterol reducing effect and study of anti-atherogenic effect.
Radix Achyranthis Bidentatae: promoting blood circulation to restore menstrual flow, invigorating the liver and kidney; Can improve liver function, reduce the plasma cholesterol effect.
Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel; Improve plasmin activity; Prolong, clotting time; Anticoagulant; Improve hemorheological properties, blood viscosity reduces, erythrocyte electrophoretic time shortens, and antithrombotic forms; Can make aorta atheromatous plaque form area and obviously reduce, serum total cholesterol, triglyceride, all decreases to some degree.Suppressing blood fat rises.Can also suppress the synthetic of cell endogenous cholesterol.
The specific embodiment
Technical solution of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: the Chinese medicine composition of present embodiment treatment hyperlipidemia is made up of the Radix Polygoni Multiflori of 20～30g, the Fructus Crataegi of 15～25g, the Flos Chrysanthemi Indici of 10～20g, the Semen Cassiae of 10～20g, the Radix Glycyrrhizae of 10～20g, the Fructus Lycii of 15～25g, the Rhizoma Dioscoreae of 10～20g, the Rhizoma Alismatis of 15～25g, the Radix Achyranthis Bidentatae of 20～30g and the Radix Salviae Miltiorrhizae of 10～20g.
The Chinese medicine composition of treatment hyperlipidemia in the present embodiment, the careful object of use: insufficiency of kidney-YANG person, blood deficiency gas are weak, the liver insufficiency of stomach is trembled with fear, antenatal puerperal.
Pack into after the Chinese medicine composition of treatment hyperlipidemia is pulverized in the present embodiment and get final product taking convenience in the stomach dissolution type 0# capsule; Consumption is secondary every day, one time 3～4; The trade name of the Chinese medicine composition of treatment hyperlipidemia is " a Yu Shi JIANGZHILING " in the present embodiment.
The specific embodiment two: present embodiment and the specific embodiment one are different is that the Chinese medicine composition of treatment hyperlipidemia is made up of the Radix Polygoni Multiflori of 20g, the Fructus Crataegi of 15g, the Flos Chrysanthemi Indici of 10g, the Semen Cassiae of 10g, the Radix Glycyrrhizae of 10g, the Fructus Lycii of 15g, the Rhizoma Dioscoreae of 10g, the Rhizoma Alismatis of 15g, the Radix Achyranthis Bidentatae of 20g and the Radix Salviae Miltiorrhizae of 10g.Other is identical with the specific embodiment one.
The specific embodiment three: present embodiment and the specific embodiment one are different is that the Chinese medicine composition of treatment hyperlipidemia is made up of the Radix Polygoni Multiflori of 30g, the Fructus Crataegi of 25g, the Flos Chrysanthemi Indici of 20g, the Semen Cassiae of 20g, the Radix Glycyrrhizae of 20g, the Fructus Lycii of 25g, the Rhizoma Dioscoreae of 20g, the Rhizoma Alismatis of 25g, the Radix Achyranthis Bidentatae of 30g and the Radix Salviae Miltiorrhizae of 20g.Other is identical with the specific embodiment one.
The specific embodiment four: present embodiment and the specific embodiment one are different is that the Chinese medicine composition of treatment hyperlipidemia is made up of the Radix Polygoni Multiflori of 22～28g, the Fructus Crataegi of 17～23g, the Flos Chrysanthemi Indici of 12～18g, the Semen Cassiae of 12～18g, the Radix Glycyrrhizae of 12～18g, the Fructus Lycii of 17～22g, the Rhizoma Dioscoreae of 11～19g, the Rhizoma Alismatis of 16～21g, the Radix Achyranthis Bidentatae of 21～27g and the Radix Salviae Miltiorrhizae of 13～17g.Other is identical with the specific embodiment one.
The specific embodiment five: present embodiment and the specific embodiment one are different is that the Chinese medicine composition of treatment hyperlipidemia is made up of the Radix Polygoni Multiflori of 25g, the Fructus Crataegi of 20g, the Flos Chrysanthemi Indici of 15g, the Semen Cassiae of 15g, the Radix Glycyrrhizae of 15g, the Fructus Lycii of 20g, the Rhizoma Dioscoreae of 15g, the Rhizoma Alismatis of 20g, the Radix Achyranthis Bidentatae of 25g and the Radix Salviae Miltiorrhizae of 15g.Other is identical with the specific embodiment one.
Pack into after the Chinese medicine composition of treatment hyperlipidemia is pulverized in the present embodiment and get final product taking convenience in the stomach dissolution type 0# capsule; Consumption is secondary every day, one time 3～4; The trade name of the Chinese medicine composition of treatment hyperlipidemia is " a Yu Shi JIANGZHILING " in the present embodiment.
Be used for the treatment of hyperlipidemia 100 examples, adopt JIANGZHINING KELI the same period in contrast, the effect of observation adjustment blood fat and the variation of hemorheology index are as follows:
1, diagnostic criteria
Diagnostic criteria with reference to Ministry of Public Health, the more old tackling key problem cooperative groups formulations of State Administration of Traditional Chinese Medicine's traditional Chinese medical science: a, T-CHOL (TC) 〉=5.70mmlol/L; B, triglyceride (TG) 〉=1.7mmlol/L; C HDL-C (HDL-C) male≤1.03mmlol/L, women 〉=1.16mmlol/L; D, low-density lipoprotein cholesterol (LDL-C) 〉=5.70mmlol/L; It is promptly diagnosable to meet 1 above person in the first three items.
2, case situation
Case derives from socialized medicine out-patient department, meets diagnostic criteria, gets rid of the hyperlipidemia person of liver, kidney, endocrine illness and drug-induced; This organizes 100 examples, 50 examples of wherein treatment group (adopting the present invention to treat the Chinese medicine composition of hyperlipidemia), male 35 examples, women 15 examples; Matched group 50 examples, male 30 examples, women 20 examples; Clinical basic feature is similar before two groups of patient treatments, and comparability is good, and living environment is basic identical.
3, observational technique
A, treatment: the treatment group, every day secondary, one time 3～4; Matched group every day three times, a 10g; 6 weeks were 1 course of treatment; Inactive other drug.
B, observation: blood fat, hemorheology, blood pressure, heart rate, electrocardio, three big conventional, liver functions.
4, result
Criterion of therapeutical effect is with reference to " clinical drug research guideline ".Produce effects: reach 1 person, promptly TC descends 〉=20%, and TG descends 〉=40%, HDL-C rising 〉=0.26mmlol/L; Effectively: reach 1 person, promptly TC descends 10～20%, and TG descends 〉=20～40%, HDL-C 〉=0.10～0.26mmlol/L that rises; Invalid: as to check not reach efficiency index person.
Two groups of general curative effects compare: treatment group, produce effects are 38 examples (76%), effectively are 7 examples (14%), and invalid is 5 examples (10%), and total effective rate is 90%; Matched group, produce effects are 17 examples (34%), effectively are 20 examples (40%), and invalid is 13 examples (26%), and total effective rate is 74%; Two groups relatively have significant difference.
Blood lipid level is relatively before and after two groups of treatments: as shown in table 1, and the treatment group, serum TC, TG, TDL-C reduce after treating, and DHL-C raises, and compares with treatment is preceding, and significant difference (P＜0.01) is arranged; Treatment group and matched group relatively obviously are being better than matched group (P＜0.01) aspect reduction TC, TG, TDL-C, the raising DHL-C.
Table 1
Blood lipid level relatively before and after two groups of treatments: treatment group treatment back whole blood contrast viscosity, plasma viscosity, erythrocyte overstock, erythrocyte electrophoresis all obviously descends.
Claims (3)
1. a Chinese medicine composition for the treatment of hyperlipidemia is characterized in that treating the Chinese medicine composition of hyperlipidemia and is made up of the Radix Polygoni Multiflori of 20～30g, the Fructus Crataegi of 15～25g, the Flos Chrysanthemi Indici of 10～20g, the Semen Cassiae of 10～20g, the Radix Glycyrrhizae of 10～20g, the Fructus Lycii of 15～25g, the Rhizoma Dioscoreae of 10～20g, the Rhizoma Alismatis of 15～25g, the Radix Achyranthis Bidentatae of 20～30g and the Radix Salviae Miltiorrhizae of 10～20g.
2. a kind of Chinese medicine composition for the treatment of hyperlipidemia according to claim 1 is characterized in that treating the Chinese medicine composition of hyperlipidemia and is made up of the Radix Polygoni Multiflori of 22～28g, the Fructus Crataegi of 17～23g, the Flos Chrysanthemi Indici of 12～18g, the Semen Cassiae of 12～18g, the Radix Glycyrrhizae of 12～18g, the Fructus Lycii of 17～22g, the Rhizoma Dioscoreae of 11～19g, the Rhizoma Alismatis of 16～21g, the Radix Achyranthis Bidentatae of 21～27g and the Radix Salviae Miltiorrhizae of 13～17g.
3. a kind of Chinese medicine composition for the treatment of hyperlipidemia according to claim 1 is characterized in that treating the Chinese medicine composition of hyperlipidemia and is made up of the Radix Polygoni Multiflori of 25g, the Fructus Crataegi of 20g, the Flos Chrysanthemi Indici of 15g, the Semen Cassiae of 15g, the Radix Glycyrrhizae of 15g, the Fructus Lycii of 20g, the Rhizoma Dioscoreae of 15g, the Rhizoma Alismatis of 20g, the Radix Achyranthis Bidentatae of 25g and the Radix Salviae Miltiorrhizae of 15g.
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Cited By (14)
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| CN103463426A (en) * | 2013-09-03 | 2013-12-25 | 陈柏林 | Traditional Chinese medicine pill for treating hyperlipidemia |
| CN103504089A (en) * | 2013-10-22 | 2014-01-15 | 浙江小二黑食品有限公司 | Weight-reducing and lipid-lowering tea and preparation method thereof |
| CN104026564A (en) * | 2013-03-05 | 2014-09-10 | 北京慧宝康源医学研究有限责任公司 | Healthcare food used for controlling human body blood fat and preparing process thereof |
| CN104189314A (en) * | 2014-09-28 | 2014-12-10 | 陈远征 | Pharmaceutical composition for treating hyperlipidemia with phlegm and turbid repression syndrome |
| CN104435207A (en) * | 2014-12-10 | 2015-03-25 | 无锡瑞年实业有限公司 | Traditional Chinese medicine granule for assistance on blood lipid reduction |
| CN104474382A (en) * | 2014-11-20 | 2015-04-01 | 周艳 | Traditional Chinese medicine for reducing blood fat and preparation method |
| CN104491218A (en) * | 2014-12-10 | 2015-04-08 | 无锡瑞年实业有限公司 | Traditional Chinese medicine oral liquid as a subsidiary for hypolipidemic |
| CN105616697A (en) * | 2014-10-30 | 2016-06-01 | 陈筠 | Traditional Chinese medicine composition for treating hyperlipidemia |
| CN105726815A (en) * | 2016-03-10 | 2016-07-06 | 姚旺东 | Chinese herbal medicine composition for treating hyperlipidemia |
| CN105902867A (en) * | 2016-06-14 | 2016-08-31 | 西安力邦制药有限公司 | Plant medicine composition for reducing hyperlipidemia, hypertension and hyperglycemia and preparation method thereof |
| CN105999043A (en) * | 2016-07-23 | 2016-10-12 | 孙茂志 | Traditional Chinese medicine composition for treating hyperlipidemia |
| CN106361890A (en) * | 2016-10-21 | 2017-02-01 | 代立新 | Traditional Chinese medicine for the treatment of high blood fat and method thereof |
| CN106511652A (en) * | 2016-09-02 | 2017-03-22 | 宋鄂 | Leech-grass eyesight-improving mixture and preparation method thereof |
| CN107095981A (en) * | 2017-05-08 | 2017-08-29 | 英山县人民医院 | A kind of Chinese medicine composition for treating phlegm blockage hyperlipemia |
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| CN104026564B (en) * | 2013-03-05 | 2016-06-29 | 北京慧宝源生物技术有限公司 | Control health food and the preparation technology thereof of human body blood fat |
| CN104026564A (en) * | 2013-03-05 | 2014-09-10 | 北京慧宝康源医学研究有限责任公司 | Healthcare food used for controlling human body blood fat and preparing process thereof |
| CN103463426A (en) * | 2013-09-03 | 2013-12-25 | 陈柏林 | Traditional Chinese medicine pill for treating hyperlipidemia |
| CN103504089A (en) * | 2013-10-22 | 2014-01-15 | 浙江小二黑食品有限公司 | Weight-reducing and lipid-lowering tea and preparation method thereof |
| CN104189314A (en) * | 2014-09-28 | 2014-12-10 | 陈远征 | Pharmaceutical composition for treating hyperlipidemia with phlegm and turbid repression syndrome |
| CN104189314B (en) * | 2014-09-28 | 2017-09-15 | 张毅 | It is a kind of to treat the turbid pharmaceutical composition for checking card high fat of blood of phlegm |
| CN105616697A (en) * | 2014-10-30 | 2016-06-01 | 陈筠 | Traditional Chinese medicine composition for treating hyperlipidemia |
| CN104474382A (en) * | 2014-11-20 | 2015-04-01 | 周艳 | Traditional Chinese medicine for reducing blood fat and preparation method |
| CN104435207A (en) * | 2014-12-10 | 2015-03-25 | 无锡瑞年实业有限公司 | Traditional Chinese medicine granule for assistance on blood lipid reduction |
| CN104491218A (en) * | 2014-12-10 | 2015-04-08 | 无锡瑞年实业有限公司 | Traditional Chinese medicine oral liquid as a subsidiary for hypolipidemic |
| CN105726815A (en) * | 2016-03-10 | 2016-07-06 | 姚旺东 | Chinese herbal medicine composition for treating hyperlipidemia |
| CN105902867A (en) * | 2016-06-14 | 2016-08-31 | 西安力邦制药有限公司 | Plant medicine composition for reducing hyperlipidemia, hypertension and hyperglycemia and preparation method thereof |
| CN105999043A (en) * | 2016-07-23 | 2016-10-12 | 孙茂志 | Traditional Chinese medicine composition for treating hyperlipidemia |
| CN106511652A (en) * | 2016-09-02 | 2017-03-22 | 宋鄂 | Leech-grass eyesight-improving mixture and preparation method thereof |
| CN106361890A (en) * | 2016-10-21 | 2017-02-01 | 代立新 | Traditional Chinese medicine for the treatment of high blood fat and method thereof |
| CN107095981A (en) * | 2017-05-08 | 2017-08-29 | 英山县人民医院 | A kind of Chinese medicine composition for treating phlegm blockage hyperlipemia |
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